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Maria Bokarewa
Professor/överläkare
Avd för reumatologi och inflammationsforskningOm Maria Bokarewa
Professor/ Överläkare vid Reumatologkliniken, Sahlgrenska Universitetssjukhuset.
Maria Bokarewa (född 1963) är läkare och reumatolog vid Reumatologkliniken, Sahlgrenska Universitetssjukhuset. Hon disputerade vid Institutet för Reumatologi i Moskva år 1991 och även vid Karolinska Institutet i Stockholm år 1995. Sedan 1998 arbetar Maria vid avdelningen för reumatologi och inflammationsforskning vid institutionen för medicin.
Forskning
Kronisk ledgångsreumatism, reumatoid artrit, är en vanligt förekommande och handikappande sjukdom som har central plats i min forskning. Tillsammans med min forskargrupp studerar jag molekylära mekanismer som är gemensamma vid artrit och cancer. Vi har visat att så kallade onkoproteiner är kopplade till intracellulära processer som sker i den inflammerade ledvävnaden vid artrit och stödjer dess aggressiva växtsätt och okontrollerade spridning till kroppens alla leder. Idag lägger vi stor vikt vid tidiga avvikelser i det adaptiva immunförsvaret som leder till utveckling av autoimmunitet och autoimmun artrit.
Vår forskning präglas av ett nära samarbete med Reumatologkliniken vid Sahlgrenska Universitetssjukhuset. Det innebär att våra projekt ofta kombinerar preklinisk forskning som experimentellt arbete med cellmaterial från patienter och artritmodeller med kliniska studier. I experimentella modeller och i patientmaterial har vi visat att onkoproteiner, som exempelvis survivin, påverkar immunförsvar och bland annat produktion av autoantikroppar.
Under de senaste åren har vi genomfört en rad framgångsrika kliniska studier som bekräftat att survivin kan förutspå utveckling av ledgångsreumatism och är associerat till sjukdomens ogynnsamma utveckling i form av skelettdestruktioner och terapiresistensen. Mer om Maria Bokarewas forskning
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Insulin Sensitivity Controls Activity of Pathogenic CD4+T Cells in Rheumatoid
Arthritis
Malin Erlandsson, Eric Malmhäll-Bah, Venkataragavan Chandrasekaran, Karin Andersson, Lisa M Nilsson, Sofia Töyrä Silfverswärd, Rille Pullerits, Maria Bokarewa
CELLS - 2024 -
Inhibitory effect of hydroxychloroquine on glucocorticoid-induced osteoporosis in lupus
therapy
Wenlin Qiu, Xiaoxiao Han, Tong Yu, Lijuan Jiang, Xuefei Wang, Ruizhi Feng, Xiaoru Duan, Yao Teng, Haifeng Yin, Maria Bokarewa, Guo-Min Deng
CLINICAL & TRANSLATIONAL IMMUNOLOGY - 2024 -
Bivalent chromatin accommodates survivin and BRG1/SWI complex to activate DNA damage response in CD4+
cells
Venkataragavan Chandrasekaran, Karin Andersson, Malin Erlandsson, Shuxiang Li, Torbjörn Nur Olsson, Maria-Jose Garcia-Bonete, Eric Malmhäll-Bah, Pegah Johansson, Gergely Katona, Maria Bokarewa
CELL COMMUNICATION AND SIGNALING - 2024 -
MicroRNA and interleukin 6 interplay in the adipose tissue of rheumatoid arthritis
patients.
Carolina Larsson, Karin Andersson, Mitra Nadali, Sofia Töyrä Silfverswärd, Maria Bokarewa, Malin Erlandsson
Clinical and experimental rheumatology - 2023 -
Metabolic signature and proteasome activity controls synovial migration of CDC42hiCD14+ cells in rheumatoid
arthritis.
Eric Malmhäll-Bah, Karin Andersson, Malin Erlandsson, Sofia Silfverswärd Lindblad, Rille Pullerits, Maria Bokarewa
Frontiers in immunology - 2023 -
Survivin prevents the polycomb repressor complex 2 from methylating histone 3 lysine
27
Maja Jensen, Venkataragavan Chandrasekaran, Maria-Jose Garcia-Bonete, S. X. Li, Atsarina Larasati Anindya, Karin Andersson, Malin Erlandsson, Nina Oparina, Björn Marcus Burmann, Ulrika Brath, A. R. Panchenko, Maria Bokarewa, Gergely Katona
Iscience - 2023 -
IGF1R signalling is a guardian of self-tolerance restricting autoantibody
production.
Malin Erlandsson, Seval Erdogan, Caroline Wasén, Karin Andersson, Sofia Töyrä Silfverswärd, Rille Pullerits, Mats Bemark, Maria Bokarewa
Frontiers in immunology - 2022 -
Chronic hyperinsulinemia promotes human hepatocyte
senescence.
Ritesh Baboota, Rosa Spinelli, Malin Erlandsson, Bruna B Brandao, Marsel Lino, Hong Yang, Adil Mardinoglu, Maria Bokarewa, Jeremie Boucher, C Ronald Kahn, Ulf Smith
Molecular metabolism - 2022 -
Survivin promotes a glycolytic switch in CD4+ T cells by suppressing the transcription of PFKFB3 in rheumatoid
arthritis.
Malin Erlandsson, Karin Andersson, Nina Oparina, Venkataragavan Chandrasekaran, Tibor Saghy, Anastasios Damdimopoulos, Maria-Jose Garcia-Bonete, Zakaria Einbeigi, Sofia Töyrä Silfverswärd, Marcela Pekna, Gergely Katona, Maria Bokarewa
iScience - 2022 -
Bayesian progress curve analysis of MicroScale thermophoresis
data
Atsarina Larasati Anindya, Maria-Jose Garcia-Bonete, Maja Jensen, Christian V Recktenwald, Maria Bokarewa, Gergely Katona
Digital Discovery - 2022 -
Rho-GTPase dependent leukocyte interaction generates pro-inflammatory thymic Tregs and causes
arthritis
Eric Malmhäll-Bah, Karin Andersson, Malin Erlandsson, Murali K Akula, Mikael Brisslert, Clotilde Wiel, Ahmed E El Zowalaty, Volkan I. Sayin, Martin O. Bergö, Maria Bokarewa
Journal of Autoimmunity - 2022 -
Cohesin-Mediated Chromatin Interactions and
Autoimmunity
Venkataragavan Chandrasekaran, N. Oparina, Maria-Jose Garcia-Bonete, C. Wasen, Malin Erlandsson, Eric Malmhäll-Bah, Karin Andersson, Maja Jensen, Sofia Töyrä Silfverswärd, Gergely Katona, Maria Bokarewa
Frontiers in Immunology - 2022 -
Insights into the Mechanism for Vertical Graphene Growth by Plasma-Enhanced Chemical Vapor
Deposition
J. Sun, T. Rattanasawatesun, P. H. Tang, Z. X. Bi, S. Pandit, Lisa Lam, Caroline Wasén, Malin Erlandsson, Maria Bokarewa, J. C. Dong, F. Ding, F. Z. Xiong, I. Mijakovic
Acs Applied Materials & Interfaces - 2022 -
Clinical Significance of Diabetes-Mellitus-Associated Antibodies in Rheumatoid
Arthritis
Malin Erlandsson, Mahomud Tuameh, Elin Jukic Huduti, Sofia Töyrä Silfverswärd, Rille Pullerits, Maria Bokarewa
Cells - 2022 -
Prognostic Significance of BIRC5/Survivin in Breast Cancer: Results from Three Independent
Cohorts.
Nina Oparina, Malin Erlandsson, Anna Fäldt Beding, Toshima Z Parris, Khalil Helou, Per Karlsson, Zakaria Einbeigi, Maria Bokarewa
Cancers - 2021 -
Impact of the Uncoupling Protein 1 on Cardiovascular Risk in Patients with Rheumatoid
Arthritis
Lovisa Lyngfelt, Malin Erlandsson, Mitra Nadali, Shahram Hedjazifar, Rille Pullerits, Karin Andersson, Petra Brembeck, Sofia Töyrä Silfverswärd, Ulf Smith, Maria Bokarewa
Cells - 2021 -
Low Soluble Receptor for Advanced Glycation End Products Precedes and Predicts Cardiometabolic Events in Women With Rheumatoid
Arthritis
Mitra Nadali, Lovisa Lyngfelt, Malin Erlandsson, Sofia Töyrä Silfverswärd, Karin Andersson, Maria Bokarewa, Rille Pullerits
Frontiers in Medicine - 2021 -
Safety and effectiveness of abatacept in systemic sclerosis: The EUSTAR
experience
I. Castellví, M. Elhai, C. Bruni, P. Airò, S. Jordan, L. Beretta, V. Codullo, C. M. Montecuco, Maria Bokarewa, F. Iannonne, A. Balbir, V. M. Hsu, O. Distler, M. Matucci-Cerinic, Y. Allanore
Seminars in Arthritis and Rheumatism - 2020 -
Aberrant expression of USF2 in refractory rheumatoid arthritis and its regulation of proinflammatory cytokines in Th17
cells.
Dan Hu, Emily C Tjon, Karin Andersson, Gabriela M Molica, Minh C Pham, Brian Healy, Gopal Murugaiyan, Nathalie Pochet, Vijay K Kuchroo, Maria Bokarewa, Howard L Weiner
Proceedings of the National Academy of Sciences of the United States of America - 2020 -
Nicotine Changes the microRNA Profile to Regulate the FOXO Memory Program of CD8(+)T Cells in Rheumatoid
Arthritis
Caroline Wasén, C. Ospelt, Alessandro Camponeschi, Malin Erlandsson, Karin Andersson, Sofia Töyrä Silfverswärd, S. Gay, Maria Bokarewa
Frontiers in Immunology - 2020 -
Mannose is an insulin-regulated metabolite reflecting whole-body insulin sensitivity in
man
E. Ferrannini, Maria Bokarewa, Petra Brembeck, Ritesh Baboota, Shahram Hedjazifar, S. Baldi, B. Campi, E. Muscelli, A. Saba, I. Sterner, Caroline Wasén, Ulf Smith
Metabolism: Clinical and Experimental - 2020 -
Protein prenylation restrains innate immunity by inhibiting Rac1 effector
interactions
Murali K Akula, Mohamed X Ibrahim, Emil G. Ivarsson, O. M. Khan, Israiel T. Kumar, Malin Erlandsson, Christin Karlsson, X. F. Xu, Mikael Brisslert, C. Brakebusch, D. Wang, Maria Bokarewa, Volkan I. Sayin, Martin O. Bergö
Nature Communications - 2019 -
Low serum IGF1 is associated with hypertension and predicts early cardiovascular events in women with rheumatoid
arthritis
Malin Erlandsson, Lovisa Lyngfelt, N David Åberg, Caroline Wasén, Rachelle A. Espino, Sofia Töyrä Silfverswärd, Mitra Nadali, Katarina Jood, Karin Andersson, Rille Pullerits, Maria Bokarewa
BMC Med - 2019 -
Effects of implant-delivered insulin on bone formation in osteoporotic
rats
Behnosh Öhrnell Malekzadeh, Malin Erlandsson, Pentti Tengvall, Anders Palmquist, Maria Ransjö, Maria Bokarewa, Anna Westerlund
Journal of Biomedical Materials Research - Part A - 2018 -
Survivin Measurement improves Clinical Prediction of Transition From Arthralgia to RA - Biomarkers to Improve Clinical Sensitivity of Transition From Arthralgia to
RA
Malin Erlandsson, Minna Turkkila, Rille Pullerits, Maria Bokarewa
Frontiers in Medicine - 2018 -
Survivin improves the early recognition of rheumatoid arthritis among patients with arthralgia: A population-based study within two university cities of
Sweden.
Malin Erlandsson, Minna Turkkila, Filip Siljehult, Rille Pullerits, Catharina Eriksson, Solbritt Rantapää-Dahlqvist, Maria Bokarewa
Seminars in arthritis and rheumatism - 2018 -
Smoking Is Associated With Low Levels of Soluble PD-L1 in Rheumatoid
Arthritis
Caroline Wasén, Malin Erlandsson, Apostolos Bossios, Linda Ekerljung, Carina Malmhäll, Sofia Töyrä Silfverswärd, Rille Pullerits, Bo Lundbäck, Maria Bokarewa
Frontiers in Immunology - 2018 -
Inflammation in the hippocampus affects IGF1 receptor signaling and contributes to neurological sequelae in rheumatoid
arthritis.
Karin Andersson, Caroline Wasén, Lina Juzokaite, Lovisa Leifsdottir, Malin Erlandsson, Sofia Töyrä Silfverswärd, Anna Stokowska, Marcela Pekna, Milos Pekny, Kjell Olmarker, Rolf A. Heckemann, Marie Kalm, Maria Bokarewa
Proceedings of the National Academy of Sciences of the United States of America - 2018 -
Low Serum IGF-1 in Boys with Recent Onset of Juvenile Idiopathic
Arthritis
Anna-Carin Lundell, Malin Erlandsson, Maria Bokarewa, H. Liivamagi, K. Uibo, S. Tarraste, T. Rebane, T. Talvik, C. Pruunsild, Rille Pullerits
Journal of Immunology Research - 2018 -
Inhibition of CCL3 abrogated precursor cell fusion and bone erosions in human osteoclast cultures and murine collagen-induced
arthritis
L. A. Jordan, Malin Erlandsson, B. F. Fenner, R. Davies, A. K. Harvey, E. H. Choy, R. Errington, Maria Bokarewa, A. S. Williams
Rheumatology (Oxford, England) - 2018 -
Bone remodelling: locus minori or unappreciated potential of
tofacitinib?
Maria Bokarewa, Malin Erlandsson
Rheumatology (Oxford, England) - 2018 -
Transcriptional signature of human pro-inflammatory T(H)17 cells identifies reduced IL10 gene expression in multiple
sclerosis
D. Hu, S. Notarbartolo, T. Croonenborghs, B. Patel, R. Cialic, T. H. Yang, D. Aschenbrenner, Karin Andersson, M. Gattorno, M. Pham, P. Kivisakk, I. V. Pierre, Y. Lee, K. Kiani, Maria Bokarewa, E. Tjon, N. Pochet, F. Sallusto, V. K. Kuchroo, H. L. Weiner
Nature Communications - 2017 -
IGF-1R signalling contributes to IL-6 production and T cell dependent inflammation in rheumatoid
arthritis.
Malin Erlandsson, Sofia Silfverswärd Lindblad, Mitra Nadali, Minna Turkkila, Mattias Svensson, Ing-Marie Jonsson, Karin Andersson, Maria Bokarewa
Biochimica et Biophysica Acta - Molecular basis of disease - 2017 -
Survivin in autoimmune
diseases.
Giacomo Gravina, Caroline Wasén, Maria-Jose Garcia-Bonete, Minna Turkkila, Malin Erlandsson, Sofia Silfverswärd Lindblad, Mikael Brisslert, Rille Pullerits, Karin Andersson, Gergely Katona, Maria Bokarewa
Autoimmunity reviews - 2017 -
Radiological features of experimental staphylococcal septic arthritis by micro computed tomography
scan.
Farah Fatima, Ying Fei, Abukar Ali, Majd Mohammad, Malin Erlandsson, Maria Bokarewa, Muhammad Nawaz, Hadi Valadi, Manli Na, Tao Jin
PloS one - 2017 -
Survivin controls biogenesis of microRNA in smokers: A link to pathogenesis of rheumatoid
arthritis.
Karin Andersson, Minna Turkkila, Malin Erlandsson, Apostolos Bossios, Sofia Silfverswärd Lindblad, Dan Hu, Linda Ekerljung, Carina Malmhäll, Howard L. Weiner, Bo Lundbäck, Maria Bokarewa
Biochimica et biophysica acta - 2017 -
Bayesian Analysis of MicroScale Thermophoresis Data to Quantify Affinity of Protein:Protein Interactions with Human
Survivin.
Maria-Jose Garcia-Bonete, Maja Jensen, Christian V Recktenwald, Sandra Rocha, Volker Stadler, Maria Bokarewa, Gergely Katona
Scientific reports - 2017 -
High Expression of STAT3 in Subcutaneous Adipose Tissue Associates with Cardiovascular Risk in Women with Rheumatoid
Arthritis.
Mitra Nadali, Rille Pullerits, Karin Andersson, Sofia Silfverswärd Lindblad, Malin Erlandsson, Maria Bokarewa
International journal of molecular sciences - 2017 -
Smoking activates cytotoxic CD8(+) T cells and causes survivin release in rheumatoid
arthritis
Caroline Wasén, Minna Turkkila, Apostolos Bossios, Malin Erlandsson, Karin Andersson, Linda Ekerljung, Carina Malmhäll, Mikael Brisslert, Sofia Silfverswärd Lindblad, Bo Lundbäck, Maria Bokarewa
Journal of Autoimmunity - 2017 -
Feeding transgenic plants that express a tolerogenic fusion protein effectively protects against
arthritis.
Charlotta Hansson, Karin Schön, Irina Kalbina, Åke Strid, Sören Andersson, Maria Bokarewa, Nils Y Lycke
Plant biotechnology journal - 2016 -
Deletion of the membrane complement inhibitor CD59a drives age and gender-dependent alterations to bone phenotype in
mice
A. C. Bloom, F. L. Collins, R. J. van't Hof, E. S. Ryan, E. Jones, T. R. Hughes, B. P. Morgan, Malin Erlandsson, Maria Bokarewa, D. Aeschlimann, B. A. J. Evans, A. S. Williams
Bone - 2016 -
Impaired signaling through the Fms-like tyrosine kinase 3 receptor increases osteoclast formation and bone damage in
arthritis.
Mattias Svensson, Malin Erlandsson, Ing-Marie Jonsson, Karin Andersson, Maria Bokarewa
Journal of leukocyte biology - 2016 -
Pathogenic Transdifferentiation of Th17 Cells Contribute to Perpetuation of Rheumatoid Arthritis during Anti-TNF
Treatment.
Karin Andersson, Nicola Cavallini, Dan Hu, Mikael Brisslert, Ron Cialic, Hadi Valadi, Malin Erlandsson, Sofia Silfverswärd Lindblad, Rille Pullerits, Vijay K Kuchroo, Howard L Weiner, Maria Bokarewa
Molecular medicine (Cambridge, Mass.) - 2015 -
Murine germinal center B cells require functional Fms-like tyrosine kinase 3 signaling for IgG1 class-switch
recombination.
Mattias Svensson, Karin Andersson, Caroline Wasén, Malin Erlandsson, Merja Nurkkala Karlsson, Ing-Marie Jonsson, Mikael Brisslert, Mats Bemark, Maria Bokarewa
Proceedings of the National Academy of Sciences of the United States of America - 2015 -
Survivin co-ordinates formation of follicular T-cells acting in synergy with
Bcl-6
Karin Andersson, Mikael Brisslert, Nicola Cavallini, Mattias Svensson, Amanda Welin, Malin Erlandsson, M. J. Ciesielski, Gergely Katona, Maria Bokarewa
Oncotarget - 2015 -
Serum survivin predicts responses to treatment in active rheumatoid arthritis: a post hoc analysis from the SWEFOT
trial
A. Levitsky, Malin Erlandsson, R. F. van Vollenhoven, Maria Bokarewa
Bmc Medicine - 2015 -
Suppressed diversity of survivin splicing in active rheumatoid
arthritis
Minna Turkkila, Karin Andersson, S. Amu, Mikael Brisslert, Malin Erlandsson, Sofia Silfverswärd Lindblad, Maria Bokarewa
Arthritis Research & Therapy - 2015 -
A unique population of IgG-expressing plasma cells lacking CD19 is enriched in human bone
marrow.
Henrik E Mei, Ina Wirries, Daniela Frölich, Mikael Brisslert, Claudia Giesecke, Joachim R Grün, Tobias Alexander, Stefanie Schmidt, Katarzyna Luda, Anja A Kühl, Robby Engelmann, Michael Dürr, Tobias Scheel, Maria Bokarewa, Carsten Perka, Andreas Radbruch, Thomas Dörner
Blood - 2015 -
Profile of circulating microRNAs in fibromyalgia and their relation to symptom severity: an exploratory
study.
Jan Bjersing, Maria Bokarewa, Kaisa Mannerkorpi
Rheumatology International - 2015 -
Recognizing rheumatoid arthritis: oncoprotein survivin opens new possibilities: a population-based case-control
study.
Too Chun-Lai, Shahnaz Murad, Malin Erlandsson, Heselynn Hussein, Wahinuddin Sulaiman, Jasbir S Dhaliwal, Maria Bokarewa
Medicine - 2015
Fler publikationer
Antalet publikationer som visas på denna sida är begränsat. Besök Göteborgs Universitets publikationsdatabas (GUP) för att söka efter fler publikationer.