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- Hans Carlsten
Hans Carlsten
Seniorforskare
Avd för reumatologi och inflammationsforskningOm Hans Carlsten
Hans Carlsten (född 1954) har genom flera studier etablerat att östrogen har en tudelad effekt på immunsystemet. Hans forskargrupp var den första som visade att könshormonernas (östrogen och testosteron) dämpande effekt på T-cells-beroende inflammation ärvs som ett dominant genetiskt anlag.
De har genomfört en systematisk beskrivning av den påverkan som östrogenreceptor α och β har på utvecklingen och regleringen av immunsystemet, genom att avända sk "knock-out" möss som saknade östrogenreceptorer. I musmodeller av autoimmuna reumatiska sjukdomar har gruppen visat att fysiologiska doser av östrogen accelerar systemisk lupus erythematosus (SLE) men skyddar vid reumatoid artrit (RA).
Professor Carlsten belönades med Nanna Svartz priset år 2009 för sitt translationella vetenskapliga arbete.
Forskningsprojekt
För närvarande studerar gruppen de cellulära och molekylära mekanismer som gör att östrogen nedreglerar artrit och förhindrar skador på skelettet vid systemisk inflammation. Professor Carlsten och medarbetare har, i kliniska studier av postmenopausala RA-patienter, visat att hormonbehandling har positiva effekter på sjukdomsaktiviteten och motverkar benskörhet liksom destruktion av lederna.
Tyvärr är långtidsbehandling med östrogen associerad med ökad risk för att utveckla bröstcancer, blodproppar och stroke. Därför har gruppen valt att fokusera på den möjliga användingen av att istället använda selektiva modulatorer av östrogenreceptorer som behandlingsmetod för artrit.
Gruppmedlemmar
- Cecilia Engdahl – Docent, Forskare
- Jauquline Nordqvist - PhD
- Annica Andersson – PhD student
- Merja Nurkkala – PhD, Forskningsingenjör 1.e
- Anna-Karin Hultgård-Ekwall – PhD, Forskare
- Beatrice Bergström – Läkare
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Circulating Baseline CXCR3+Th2 and Th17 Cell Proportions Correlate With Trabecular Bone Loss After 48 Weeks of Biological Treatment in Early Rheumatoid
Arthritis
Julia Scheffler, Christina Drevinge, Catharina Lindholm, Inger Gjertsson, Kristina Lend, Merete Lund Hetland, Mikkel Ostergaard, Till Uhlig, Marte Schrumpf Heiberg, Espen A. Haavardsholm, Michael T. Nurmohamed, Jon Lampa, Tuulikki Sokka-Isler, Dan Nordstrom, Kim Horslev-Petersen, Bjorn Gudbjornsson, Gerdur Grondal, Ronald van Vollenhoven, Hans Carlsten, Mattias Lorentzon, Anna-Karin Hultgård Ekwall, Anna Rudin, Ulrika Islander
ACR OPEN RHEUMATOLOGY - 2025 -
Role of estrogen signaling in fibroblastic reticular cells for innate and adaptive immune responses in antigen-induced
arthritis
Aidan Barrett, Karin Horkeby, Carmen Corciulo, Hans Carlsten, Marie K Lagerquist, Julia Scheffler, Ulrika Islander
Immunology and Cell Biology - 2024 -
Local Immune Activation and Age Impact on Humoral Immunity in Mice, with a Focus on IgG
Sialylation.
Priti Gupta, Tibor Sághy, Miriam Bollmann, Tao Jin, Claes Ohlsson, Hans Carlsten, Carmen Corciulo, Cecilia Engdahl
Vaccines - 2024 -
Treatment with a tissue-selective oestrogen complex does not affect disease pathology but reduces pre-BI cells in lupus-prone
mice.
Christina Drevinge, Julia Scheffler, Jauqueline Nordqvist, Cecilia Engdahl, Hans Carlsten, Ulrika Islander
Scandinavian journal of rheumatology - 2024 -
Impact of estrogen on IgG glycosylation and serum protein glycosylation in a murine model of healthy
postmenopause.
Priti Gupta, Tibor Sághy, Jauqueline Nordqvist, Jonas Nilsson, Hans Carlsten, Karin Horkeby, Petra Henning, Cecilia Engdahl
Frontiers in endocrinology - 2023 -
Bazedoxifene does not share estrogens effects on IgG
sialylation
Priti Gupta, Karin Horkeby, Hans Carlsten, Petra Henning, Cecilia Engdahl
Plos One - 2023 -
Physiological estrogen levels are dispensable for the sex difference in immune responses during allergen-induced airway
inflammation
Aidan Barrett, Piotr Humeniuk, Christina Drevinge, Carmen Corciulo, Julie Weidner, Madeleine Rådinger, Hans Carlsten, Julia M. Scheffler, Ulrika Islander
Immunobiology - 2023 -
A tissue-selective estrogen complex as treatment of osteoporosis in experimental
lupus
Jauqueline Nordqvist, Cecilia Engdahl, Julia M. Scheffler, Priti Gupta, Karin L. Gustafsson, Marie K Lagerquist, Hans Carlsten, Ulrika Islander
Lupus - 2022 -
Reduction of Mature B Cells and Immunoglobulins Results in Increased Trabecular
Bone
Marie K Lagerquist, P. Gupta, E. Sehic, Karin L Horkeby, Julia M. Scheffler, Jauqueline Nordqvist, Lina Lawenius, Ulrika Islander, Carmen Corciulo, Petra Henning, Hans Carlsten, Cecilia Engdahl
Jbmr Plus - 2022 -
ER alpha Signaling in a Subset of CXCL12-Abundant Reticular Cells Regulates Trabecular Bone in
Mice
Julia M. Scheffler, Karin L. Gustafsson, Aidan Barrett, Carmen Corciulo, Christina Drevinge, Alicia M. del Carpio Pons, Piotr Humeniuk, Cecilia Engdahl, J. A. Gustafsson, Claes Ohlsson, Hans Carlsten, Marie K Lagerquist, Ulrika Islander
JBMR Plus - 2022 -
Factors associated with changes in volumetric bone mineral density and cortical area in men with ankylosing spondylitis: a 5-year prospective study using
HRpQCT
Anna Deminger, Eva Klingberg, Mattias Lorentzon, M. Hedberg, Hans Carlsten, Lennart T. H. Jacobsson, Helena Forsblad d'Elia
Osteoporosis International - 2022 -
Immunoglobulin G complexes without sialic acids enhance osteoclastogenesis but do not affect arthritis-mediated bone
loss.
Edina Sehic, Anna Westerlund, Marie K Lagerquist, Ulf H Lerner, Hans Carlsten, Petra Henning, Cecilia Engdahl
Scandinavian journal of immunology - 2021 -
Elevated serum level of hepatocyte growth factor predicts development of new syndesmophytes in men with ankylosing
spondylitis
Anna Deminger, Eva Klingberg, Merja Nurkkala, Mats Geijer, Hans Carlsten, Lennart T. H. Jacobsson, Helena Forsblad d'Elia
Rheumatology - 2021 -
Intermediate monocytes correlate with CXCR3(+) Th17 cells but not with bone characteristics in untreated early rheumatoid
arthritis
Christina Drevinge, Julia M. Scheffler, Catalin Koro-Arvidsson, Daniel Sundh, Hans Carlsten, Inger Gjertsson, Catharina Lindholm, Mattias Lorentzon, Anna Rudin, Anna-Karin Hultgård Ekwall, Ulrika Islander
Plos One - 2021 -
Androgen Receptors in Epithelial Cells Regulate Thymopoiesis and Recent Thymic Emigrants in Male
Mice
Anna S K Wilhelmson, Marta Lantero Rodriguez, Inger Johansson, Elin Svedlund Eriksson, Alexandra Stubelius, Susanne Lindgren, Johan Bourghardt Fagman, P. J. Fink, Hans Carlsten, Olov Ekwall, Åsa Tivesten
Frontiers in Immunology - 2020 -
Interleukin 17A: a Janus-faced regulator of
osteoporosis
Julia M. Scheffler, Louise Grahnemo, Cecilia Engdahl, Christina Drevinge, Karin L. Gustafsson, Carmen Corciulo, Lina Lawenius, Y. Iwakura, Klara Sjögren, Marie Lagerquist, Hans Carlsten, Claes Ohlsson, Ulrika Islander
Scientific Reports - 2020 -
Osteoporosis in a murine model of postmenopausal
lupus
Jauqueline Nordqvist, Marie K Lagerquist, Louise Grahnemo, A. Koskela, Ulrika Islander, Hans Carlsten
Lupus - 2020 -
The Rheumatoid Arthritis Risk Gene AIRE Is Induced by Cytokines in Fibroblast-Like Synoviocytes and Augments the Pro-inflammatory
Response
Beatrice Bergström, Christina Lundqvist, Georgios Vasileiadis, Hans Carlsten, Olov Ekwall, Anna-Karin H Ekwall
Frontiers in Immunology - 2019 -
Hepatocyte growth factor is a potential biomarker for osteoproliferation and osteoporosis in ankylosing
spondylitis
Linda Torres, Eva Klingberg, Merja Nurkkala, Hans Carlsten, Helena Forsblad d'Elia
Osteoporosis International - 2019 -
Weight loss improves disease activity in patients with psoriatic arthritis and obesity: an interventional
study
Eva Klingberg, Annelie Bilberg, Sofia Björkman, M. Hedberg, Lennart T. H. Jacobsson, Helena Forsblad d'Elia, Hans Carlsten, Björn Eliasson, Ingrid Larsson
Arthritis Res Ther - 2019 -
A distinct gut microbiota composition in patients with ankylosing spondylitis is associated with increased levels of fecal
calprotectin
Eva Klingberg, Maria K Magnusson, Hans Strid, Anna Deminger, Arne Ståhl, Johanna Sundin, Magnus Simrén, Hans Carlsten, Lena Öhman, Helena Forsblad d'Elia
Arthritis Research & Therapy - 2019 -
Testosterone is an endogenous regulator of BAFF and splenic B cell
number
Anna S K Wilhelmson, Marta Lantero Rodriguez, Alexandra Stubelius, Per Fogelstrand, Inger Johansson, M. B. Buechler, S. Lianoglou, V. N. Kapoor, Maria E Johansson, Johan Bourghardt Fagman, A. Duhlin, P. Tripathi, Alessandro Camponeschi, B. T. Porse, A. G. Rolink, Hans Nissbrandt, S. J. Turley, Hans Carlsten, Inga-Lill Mårtensson, M. C. I. Karlsson, Åsa Tivesten
Nature Communications - 2018 -
ER alpha expression in T lymphocytes is dispensable for estrogenic effects in
bone
Karin L. Gustafsson, Karin H. Nilsson, Helen H. Farman, Vikte Lionikaite, Petra Henning, Jianyao Wu, Sara H Windahl, Ulrika Islander, Sofia Moverare-Skrtic, Klara Sjögren, Hans Carlsten, Claes Ohlsson, Marie Lagerquist
Journal of Endocrinology - 2018 -
Testosterone Protects Against Atherosclerosis in Male Mice by Targeting Thymic Epithelial
Cells.
Anna S K Wilhelmson, Marta Lantero Rodriguez, Elin Svedlund Eriksson, Inger Johansson, Per Fogelstrand, Alexandra Stubelius, Susanne Lindgren, Johan Bourghardt Fagman, Göran K Hansson, Hans Carlsten, Mikael C I Karlsson, Olov Ekwall, Åsa Tivesten
Arteriosclerosis, thrombosis, and vascular biology - 2018 -
A five-year prospective study of spinal radiographic progression and its predictors in men and women with ankylosing
spondylitis
Anna Deminger, Eva Klingberg, M. Geijer, J. Gothlin, M. Hedberg, E. Rehnberg, Hans Carlsten, Lennart T. H. Jacobsson, Helena Forsblad d'Elia
Arthritis Research & Therapy - 2018 -
Roles of activating functions 1 and 2 of estrogen receptor α in
lymphopoiesis.
Annica Andersson, Sofia Movérare-Skrtic, Angelina I Bernardi, Helen H. Farman, Pierre Chambon, Cecilia Engdahl, Marie Lagerquist, Sara H Windahl, Hans Carlsten, Claes Ohlsson, Ulrika Islander
The Journal of endocrinology - 2018 -
Age-associated B cells expanded in autoimmune mice are memory cells sharing H-CDR3-selected
repertoires
Alaitz Aranburu, Nina Höök, Natalija Gerasimcik, Bjorn Corleis, Weicheng Ren, Alessandro Camponeschi, Hans Carlsten, Ola Grimsholm, Inga-Lill Mårtensson
European Journal of Immunology - 2018 -
Methotrexate inhibits effects of platelet-derived growth factor and interleukin-1β on rheumatoid arthritis fibroblast-like
synoviocytes
Beatrice Bergström, Hans Carlsten, Anna-Karin H Ekwall
Arthritis Research and Therapy - 2018 -
A longitudinal study of fecal calprotectin and the development of inflammatory bowel disease in ankylosing
spondylitis
Eva Klingberg, Hans Strid, Arne Ståhl, Anna Deminger, Hans Carlsten, Lena Öhman, Helena Forsblad d'Elia
Arthritis Research & Therapy - 2017 -
Which measuring site in ankylosing spondylitis is best to detect bone loss and what predicts the decline: results from a 5-year prospective
study
Anna Deminger, Eva Klingberg, Mattias Lorentzon, Mats Geijer, Jan Göthlin, Martin Hedberg, Eva Rehnberg, Hans Carlsten, Lennart T. H. Jacobsson, Helena Forsblad d'Elia
Arthritis Research & Therapy - 2017 -
Ovarian hormones in innate
inflammation
Alexandra Stubelius, Annica Andersson, Ulrika Islander, Hans Carlsten
Immunobiology - 2017 -
Effects of a tissue-selective estrogen complex on B lymphopoiesis and B cell
function
Jauqueline Nordqvist, Angelina I Bernardi, Ulrika Islander, Hans Carlsten
Immunobiology - 2017 -
SERMs have substance-specific effects on bone, and these effects are mediated via ER alpha AF-1 in female
mice
Anna E Börjesson, Helen H. Farman, Sofia Movérare-Skrtic, Cecilia Engdahl, M. C. Antal, A. Koskela, J. Tuukkanen, Hans Carlsten, A. Krust, P. Chambon, Klara Sjögren, Marie K Lagerquist, Sara H Windahl, Claes Ohlsson
American Journal of Physiology-Endocrinology and Metabolism - 2016 -
Selective oestrogen receptor modulators lasofoxifene and bazedoxifene inhibit joint inflammation and osteoporosis in ovariectomised mice with collagen-induced
arthritis.
Annica Andersson, Angelina I Bernardi, Alexandra Stubelius, Merja Nurkkala Karlsson, Claes Ohlsson, Hans Carlsten, Ulrika Islander
Rheumatology (Oxford, England) - 2016 -
Suppression of Experimental Arthritis and Associated Bone Loss by a Tissue-Selective Estrogen
Complex.
Annica Andersson, Angelina I Bernardi, Merja Nurkkala Karlsson, Alexandra Stubelius, Louise Grahnemo, Claes Ohlsson, Hans Carlsten, Ulrika Islander
Endocrinology - 2016 -
Ncf1 affects osteoclast formation but is not critical for postmenopausal bone
loss
Alexandra Stubelius, Annica Andersson, R. Holmdahl, Claes Ohlsson, Ulrika Islander, Hans Carlsten
BMC Musculoskeletal Disorders - 2016 -
IL-17-producing γδT cells are regulated by estrogen during development of experimental
arthritis.
Annica Andersson, Louise Grahnemo, Cecilia Engdahl, Alexandra Stubelius, Marie K Lagerquist, Hans Carlsten, Ulrika Islander
Clinical immunology (Orlando, Fla.) - 2015 -
Androgens regulate bone marrow B lymphopoiesis in male mice by targeting osteoblast-lineage
cells.
Anna S K Wilhelmson, Alexandra Stubelius, Anna E Börjesson, Jianyao Wu, Anna Stern, Stephen Malin, Inga-Lill Mårtensson, Claes Ohlsson, Hans Carlsten, Åsa Tivesten
Endocrinology - 2015 -
Trabecular bone loss in collagen antibody-induced
arthritis
Louise Grahnemo, Annica Andersson, Merja Nurkkala Karlsson, Alexandra Stubelius, Marie K Lagerquist, Mattias Svensson, Claes Ohlsson, Hans Carlsten, Ulrika Islander
Arthritis Research & Therapy - 2015 -
Selective estrogen receptor modulators in T cell development and T cell dependent
inflammation
Angelina I Bernardi, Annica Andersson, Alexandra Stubelius, Louise Grahnemo, Hans Carlsten, Ulrika Islander
Immunobiology - 2015 -
Possible role of lymphocytes in glucocorticoid-induced increase in trabecular bone mineral
density.
Louise Grahnemo, Caroline Jochems, Annica Andersson, Cecilia Engdahl, Claes Ohlsson, Ulrika Islander, Hans Carlsten
The Journal of endocrinology - 2015 -
Effects of lasofoxifene and bazedoxifene on B cell development and
function.
Angelina I Bernardi, Annica Andersson, Louise Grahnemo, Merja Nurkkala Karlsson, Claes Ohlsson, Hans Carlsten, Ulrika Islander
Immunity, inflammation and disease - 2014 -
The effect of estrogen on bone requires ER alpha in nonhematopoietic cells but is enhanced by ER alpha in hematopoietic
cells
Petra Henning, Claes Ohlsson, Cecilia Engdahl, Helen H. Farman, Sara H Windahl, Hans Carlsten, Marie K Lagerquist
American Journal of Physiology-Endocrinology and Metabolism - 2014 -
Biomarkers of Bone Metabolism in Ankylosing Spondylitis in Relation to Osteoproliferation and
Osteoporosis
Eva Klingberg, Merja Nurkkala, Hans Carlsten, Helena Forsblad d'Elia
Journal of Rheumatology - 2014 -
The role of total and cartilage-specific estrogen receptor alpha expression for the ameliorating effect of estrogen treatment on
arthritis.
Cecilia Engdahl, Anna E Börjesson, Huamei Forsman, Annica Andersson, Alexandra Stubelius, Andree Krust, Pierre Chambon, Ulrika Islander, Claes Ohlsson, Hans Carlsten, Marie K Lagerquist
Arthritis research & therapy - 2014 -
Immunomodulation by the estrogen metabolite
2-methoxyestradiol
Alexandra Stubelius, Malin Erlandsson, Ulrika Islander, Hans Carlsten
Clinical Immunology - 2014 -
Role of Androgen and Estrogen Receptors for the Action of Dehydroepiandrosterone
(DHEA)
Cecilia Engdahl, Marie K Lagerquist, Alexandra Stubelius, Annica Andersson, Erik Studer, Claes Ohlsson, Lars Westberg, Hans Carlsten, Helena Forsblad d'Elia
Endocrinology - 2014 -
The estrogen receptor antagonist ICI 182,780 can act both as an agonist and an inverse agonist when estrogen receptor α AF-2 is
modified.
Sofia Movérare-Skrtic, Anna E Börjesson, Helen H. Farman, Klara Sjögren, Sara H Windahl, Marie K Lagerquist, Annica Andersson, Alexandra Stubelius, Hans Carlsten, Jan-Åke Gustafsson, Claes Ohlsson
Proceedings of the National Academy of Sciences of the United States of America - 2014 -
The role of activation functions 1 and 2 of estrogen receptor-alpha for the effects of estradiol and selective estrogen receptor modulators in male
mice
Anna E Börjesson, Helen H. Farman, Cecilia Engdahl, A. Koskela, Klara Sjögren, Jenny Kindblom, Alexandra Stubelius, Ulrika Islander, Hans Carlsten, M. C. Antal, A. Krust, P. Chambon, J. Tuukkanen, Marie K Lagerquist, Sara H Windahl, Claes Ohlsson
Journal of Bone and Mineral Research - 2013 -
Soluble E-cadherin in Systemic Lupus
Erythematosus.
Tao Jin, Katarina Almehed, Yihong Zhu, Hans Carlsten, Helena Forsblad d'Elia
The Journal of rheumatology - 2013
Fler publikationer
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