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Volkan Sayin
Universitetslektor
Avd för kirurgiOm Volkan Sayin
Volkan Sayin är bland annat aktiv forskare vid Sahlgrenska Cancer Center SCC, där han fokuserar inom forskningsområdet - Grundläggande sjukdomsmekanismer/ tumörbiologi. Läs mer om deras forskning på SCC
Aktuella projekt är bland annat En precisionsmedicinplattform för att identifiera nya redoxberoende metaboliska sårbarheter i lungcancer
Han är också verksam vid Wallenbergcentrum för molekylär och translationell medicin vid Göteborgs universitet, där han leder en forskargrupp med fokus på lungcancer. Länk till Volkan Sayin group
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Ageing promotes metastasis via activation of the integrated stress
response.
Angana Patel, Jozefina Dzanan, Kevin Ali, Ella Äng, Samantha W Alvarez, Dorota Raj, Martin Dankis, Ilayda Altinönder, Maria Schwarz, Kristell Le Gal Beneroso, Emre Bedel, Ahmed Ezat El Zowalaty, Emma Jonasson, Heba Albatrok, Nadia Gul, Jozef P. Bossowski, Ray Pillai, Patrick Micke, Johan Botling, Levent Akyürek, Davide Angeletti, Sama Sayin, Anetta Härtlova, Thales Papagiannakopoulos, Roger Olofsson Bagge, Anders Ståhlberg, Andreas Hallqvist, Clotilde Wiel, Volkan Sayin
Nature - 2026 -
The integrated stress response promotes immune evasion through lipocalin
2
Jozef P. Bossowski, Ray Pillai, John Kilian, Angela Wong Lau, Mari Nakamura, Ali Rashidfarrokhi, Yuan Hao, Ruxuan Li, Katherine Wu, Takamitsu Hattori, Eliezra Glasser, Akiko Koide, Lidong Wang, Andre L. Moreira, Cristina Hajdu, Sahith Rajalingam, Sarah E. LeBoeuf, Hortense Le, Seungeun Lee, Jin Woo Oh, Cheolyong Joe, Hyemin Kim, Chan Young Ock, Se Hoon Lee, Hao Wang, Angana Patel, Volkan Sayin, Aristotelis Tsirigos, Kwok Kin Wong, Sergei B. Koralov, Mario Pende, Francisco J. Sánchez-Rivera, Diane M. Simeone, Ioannis K. Zervantonakis, Shohei Koide, Thales Papagiannakopoulos
Nature - 2026 -
Amino acid restriction sensitizes lung cancer cells to ferroptosis via GCN2-dependent activation of the integrated stress
response
Viktor Antonsson Garellick, Nadia Gul, Parvin Horrieh, Dyar Mustafa, Angana Patel, Martin Dankis, Samantha Alvarez, Johanna Berndtson, Saeed Saeed Mahdavi, Maria Schwarz, Andreas Persson, Fikret Zahirovic, Clotilde Wiel, Volkan Sayin, Per Lindahl
REDOX BIOLOGY - 2026 -
Brain metastasis in stage IV lung adenocarcinoma is frequently missed by symptom-based
screening
Sama Sayin, Ella Äng, Moa Beischer, Torill Moe, Kevin Ali, Kerstin Gunnarsson, Moe Xylander, Lars Ny, Asgeir Jakola, Ida Häggström, Clotilde Wiel, Andreas Hallqvist, Volkan Sayin
Discover Oncology - 2026 -
Identification of a BACH1 lung cancer signature: A novel tool for understanding BACH1 biology and identifying new
inhibitors
Donika Klenja-Skudrinja, Kevin Ali, David Walker, Maureen Higgins, Angana Patel, Dorota Raj, Anna Creelman, Charlotte Mcdowall, Conor Taylor, Tomasz Wenta, Erik Lekholm, Clotilde Wiel, Volkan Sayin, Laureano de la Vega
REDOX BIOLOGY - 2025 -
BRAF inhibition increases TGFβ2 production and stimulates metastasis in mice with endogenous BRAFV600E-induced hepatocellular
carcinoma
Jaroslaw Cisowski, Ahmed El Zowalaty, Sama Sayin, Piotr Czarnota, Tomasz Gromowski, Ella Äng, Muhammad Kashif, Angana Patel, Antonio Molinaro, Per Lindahl, Clotilde Wiel, Volkan Sayin, Martin O. Bergo
Proceedings of the National Academy of Sciences of the United States of America - 2025 -
High baseline PD-1+CD8 T Cells and TIGIT+CD8 T Cells in circulation associated with response to PD-1 blockade in patients with non-small cell lung
cancer
Nikita Dutta, Johanna Svensson, George-Alehandro Saad, Marielle Mello, Ella Äng, Ilayda Altinönder, Per Torstensson, Volkan Sayin, Anna Rohlin, Herve Luche, Andreas Hallqvist, Sukanya Raghavan
CANCER IMMUNOLOGY IMMUNOTHERAPY - 2025 -
Monotherapy With Immune Checkpoint Blockade Improves Survival Outcomes in KRAS-Mutant but Not KRAS Wild-Type Metastatic Lung Adenocarcinoma: Validation From an Extended Swedish
Cohort
Ella Äng, Sama Sayin, Jonas Smith Jonsson, Hannes Nilsson van Renswoude, Jan Nyman, Andreas Hallqvist, Clotilde Wiel, Volkan Sayin
JTO CLINICAL AND RESEARCH REPORTS - 2025 -
Involvement of KEAP1/NRF2 pathway in non-BRAF mutated squamous cell carcinoma of the
thyroid
Elin Schoultz, Jakob Dahlberg, Lisa M Nilsson, Jozefina J. Dzanan, Therese Carlsson, Niklas Dahr, Ellinor Andersson, Ghayeb Muhammad, Andreas Muth, Erik Elias, Henrik Fagman, Volkan I. Sayin, Jonas A Nilsson, Mikael Nilsson
Journal of Pathology - 2025 -
Nuclear AGO2 supports influenza A virus replication through type-I interferon
regulation.
Hsiang-Chi Huang, Michelle Fong, Iwona Nowak, Evgeniia Shcherbinina, Vivian Lobo, Danica F Besavilla, Hang Thuy Huynh, Karin Schön, Jakub O Westholm, Carola Fernandez, Angana A. H. Patel, Clotilde Wiel, Volkan I. Sayin, Dimitrios G Anastasakis, Davide Angeletti, Aishe A. Sarshad
Nucleic Acids Research - 2025 -
Novel insights into the BACH1-NRF2 axis; new target genes and
inhibitors
Donika Klenja-Skudrinja, Kevin X. Ali, Volkan I. Sayin, Laureano de la Vega
FREE RADICAL BIOLOGY AND MEDICINE - 2025 -
Comprehensive genetic variant analysis reveals combination of KRAS and LRP1B as a predictive biomarker of response to immunotherapy in patients with non-small cell lung
cancer.
Ella Äng Eklund, Johanna Svensson, Louise Stauber Näslund, Maria Yhr, Sama I Sayin, Clotilde Wiel, Levent Akyürek, Per Torstensson, Volkan I. Sayin, Andreas Hallqvist, Sukanya Raghavan, Anna Rohlin
Journal of Experimental & Clinical Cancer Research - 2025 -
Equalizing prognostic disparities in KRAS-mutated stage III NSCLC patients: addition of durvalumab to combined chemoradiotherapy improves
survival.
Ella A Eklund, Mathilda Orgard, Delice Wallin, Sama I Sayin, Henrik Fagman, Johan Isaksson, Sukanya Raghavan, Levent Akyürek, Jan Nyman, Clotilde Wiel, Andreas Hallqvist, Volkan I. Sayin
Lung Cancer - 2025 -
Distinct metastatic organotropism shapes prognosis in lung adenocarcinoma with brain
metastasis
Sama I Sayin, Ella M. Eklund, Kevin X. Ali, Jozefina J. Dzanan, Moe Xylander, Martin Dankis, Per Lindahl, Volkan I. Sayin, Andreas Hallqvist, Clotilde Wiel
FRONTIERS IN ONCOLOGY - 2025 -
Assessing the prognostic value of KRAS mutation combined with tumor size in stage I-II non-small cell lung cancer: a retrospective
analysis
Ella A Eklund, Ali Mourad, Clotilde Wiel, Sama I. Sayin, Henrik Fagman, Andreas Hallqvist, Volkan I. Sayin
Frontiers in Oncology - 2024 -
The pleiotropic functions of reactive oxygen species in
cancer
Katherine Wu, Ahmed E El Zowalaty, Volkan I. Sayin, Thales Papagiannakopoulos
NATURE CANCER - 2024 -
Glutamine antagonist DRP-104 suppresses tumor growth and enhances response to checkpoint blockade in KEAP1 mutant lung
cancer
Ray Pillai, Sarah E. LeBoeuf, Yuan Hao, Connie New, Jenna L.E. Blum, Ali Rashidfarrokhi, Shih Ming Huang, Christian Bahamon, Warren L. Wu, Burcu Karadal-Ferrena, Alberto Herrera, Ellie Ivanova, Michael Cross, Jozef P. Bossowski, Hongyu Ding, Makiko Hayashi, Sahith Rajalingam, Triantafyllia Karakousi, Volkan I. Sayin, Kamal M. Khanna, Kwok Kin Wong, Robert Wild, Aristotelis Tsirigos, John T. Poirier, Charles M. Rudin, Shawn M. Davidson, Sergei B. Koralov, Thales Papagiannakopoulos
Science Advances - 2024 -
Pulmonary adenocarcinoma in situ and minimally invasive adenocarcinomas in European patients have less KRAS and more EGFR mutations compared to advanced
adenocarcinomas.
Jennie Petterson, Dyar Mustafa, Sashidar Bandaru, Ella Äng Eklund, Andreas Hallqvist, Volkan I. Sayin, Andréanne Gagné, Henrik Fagman, Levent Akyürek
International Journal of Molecular Sciences - 2024 -
Excessive copper impairs intrahepatocyte trafficking and secretion of selenoprotein
P.
Maria Schwarz, Caroline E Meyer, Alina Löser, Kristina Lossow, Julian Hackler, Christiane Ott, Susanne Jäger, Isabelle Mohr, Ella A Eklund, Angana A. H. Patel, Nadia Gul, Samantha Alvarez, Ilayda Altinonder, Clotilde Wiel, Maria Maares, Hajo Haase, Anetta Härtlova, Tilman Grune, Matthias B Schulze, Tanja Schwerdtle, Uta Merle, Hans Zischka, Volkan I. Sayin, Lutz Schomburg, Anna P Kipp
Nature communications - 2023 -
Combinatory analysis of immune cell subsets and tumor-specific genetic variants predict clinical response to PD-1 blockade in patients with non-small cell lung
cancer
Nikita Dutta, Anna Rohlin, Ella A Eklund, Maria K Magnusson, Frida Nilsson, Levent Akyürek, Per Torstensson, Volkan I. Sayin, Anna Lundgren, Andreas Hallqvist, Sukanya Raghavan
Frontiers in Oncology - 2023 -
Tissue specificity of oncogenic BRAF targeted to lung and thyroid through a shared lineage
factor
Elin Schoultz, Shawn Liang, Therese Carlsson, Stefan Filges, Anders Ståhlberg, Henrik Fagman, Clotilde Wiel, Volkan I. Sayin, Mikael Nilsson
ISCIENCE - 2023 -
A MYC-controlled redox switch protects B lymphoma cells from EGR1-dependent
apoptosis
H. D. Yao, X. Chen, T. Wang, M. Kashif, X. Qiao, E. Tüksammel, L. G. Larsson, S. Okret, Volkan I. Sayin, H. Qian, M. O. Bergo
Cell Reports - 2023 -
Biotinylation of an acetylenic tricyclic bis(cyanoenone) lowers its potency as an NRF2 activator while creating a novel activity against
BACH1
R. Moreno, L. Casares, M. Higgins, Kevin X. Ali, T. Honda, Clotilde Wiel, Volkan I. Sayin, A. T. Dinkova-Kostova, L. de la Vega
Free Radical Biology and Medicine - 2022 -
Rho-GTPase dependent leukocyte interaction generates pro-inflammatory thymic Tregs and causes
arthritis
Eric Malmhäll-Bah, Karin Andersson, Malin Erlandsson, Murali K Akula, Mikael Brisslert, Clotilde Wiel, Ahmed E El Zowalaty, Volkan I. Sayin, Martin O. Bergö, Maria Bokarewa
Journal of Autoimmunity - 2022 -
The synthetic triterpenoids CDDO-TFEA and CDDO-Me, but not CDDO, promote nuclear exclusion of BACH1 impairing its
activity
L. Casares, R. Moreno, Kevin X. Ali, M. Higgins, S. D. Naidu, G. Neill, L. Cassin, A. E. Kiib, E. B. Svenningsen, A. Minassi, T. Honda, T. B. Poulsen, Clotilde Wiel, Volkan I. Sayin, A. T. Dinkova-Kostova, D. Olagnier, L. de la Vega
Redox Biology - 2022 -
KRAS mutations impact clinical outcome in metastatic non-small cell lung
cancer.
Ella A Eklund, Clotilde Wiel, Henrik Fagman, Levent Akyürek, Sukanya Raghavan, Jan Nyman, Andreas Hallqvist, Volkan I. Sayin
Cancers - 2022 -
Cellular Redox
Homeostasis
Kristell Le Gal, E. E. Schmidt, Volkan I. Sayin
Antioxidants - 2021 -
Antioxidants promote intestinal tumor progression in
mice.
Zhiyuan V. Zou, Kristell Le Gal, Ahmed E El Zowalaty, Lara Pehlivanoglu, Viktor Garellick, Nadia Gul, Mohamed X Ibrahim, Per-Olof Bergh, Marcus Henricsson, Clotilde Wiel, Levent Akyürek, Martin Bergö, Volkan I. Sayin, Per Lindahl
Antioxidants - 2021 -
Mitochondria-Targeted Antioxidants MitoQ and MitoTEMPO Do Not Influence BRAF-Driven Malignant Melanoma and KRAS-Driven Lung Cancer Progression in
Mice
Kristell Le Gal, Clotilde Wiel, M. X. Ibrahim, Marcus Henricsson, Volkan I. Sayin, M. O. Bergo
Antioxidants - 2021 -
Knockout of the RAS endoprotease RCE1 accelerates myeloid leukemia by downregulating
GADD45b.
Christin Karlsson, Murali K Akula, Anna Staffas, Jaroslaw Cisowski, Volkan I. Sayin, Mohamed X Ibrahim, Per Lindahl, Martin Bergö
Leukemia - 2020 -
Genomic profiling of the transcription factor Zfp148 and its impact on the p53
pathway
Zhiyuan V. Zou, Nadia Gul, Markus Lindberg, Abdulmalik Bokhari, Ella M. Eklund, Viktor Garellick, Angana A. H. Patel, Jozefina J. Dzanan, Ben Titmuss, Kristell Le Gal, Inger Johansson, Åsa Tivesten, Eva Forssell-Aronsson, Martin O. Bergö, Anna Staffas, Erik Larsson, Volkan I. Sayin, Per Lindahl
Scientific Reports - 2020 -
Activation of Oxidative Stress Response in Cancer Generates a Druggable Dependency on Exogenous Non-essential Amino
Acids
S. E. LeBoeuf, W. R. L. Wu, T. R. Karakousi, B. Karadal, S. R. Jackson, S. M. Davidson, K. K. Wong, S. B. Koralov, Volkan I. Sayin, T. Papagiannakopoulos
Cell Metabolism - 2020 -
Protein prenylation restrains innate immunity by inhibiting Rac1 effector
interactions
Murali K Akula, Mohamed X Ibrahim, Emil G. Ivarsson, O. M. Khan, Israiel T. Kumar, Malin Erlandsson, Christin Karlsson, X. F. Xu, Mikael Brisslert, C. Brakebusch, D. Wang, Maria Bokarewa, Volkan I. Sayin, Martin O. Bergö
Nature Communications - 2019 -
Targeting Metabolic Bottlenecks in Lung
Cancer.
Volkan I. Sayin, Sarah E LeBoeuf, Thales Papagiannakopoulos
Trends in cancer - 2019 -
BACH1 Stabilization by Antioxidants Stimulates Lung Cancer
Metastasis
Clotilde Wiel, Kristell Le Gal, M. X. Ibrahim, C. A. Jahangir, M. Kashif, H. D. Yao, Dorian V. Ziegler, X. F. Xu, Tanushree Ghosh, Tanmoy Mondal, Chandrasekhar Kanduri, Per Lindahl, Volkan I. Sayin, Martin O. Bergö
Cell - 2019 -
TrxR1, Gsr, and oxidative stress determine hepatocellular carcinoma
malignancy
M. R. McLoughlin, D. J. Orlicky, J. R. Prigge, P. Krishna, E. A. Talago, I. R. Cavigli, S. Eriksson, C. G. Miller, J. A. Kundert, Volkan I. Sayin, R. A. Sabol, J. Heinemann, L. O. Brandenberger, S. V. Iverson, B. Bothner, T. Papagiannakopoulos, C. T. Shearn, E. S. J. Arner, E. E. Schmidt
Proceedings of the National Academy of Sciences of the United States of America - 2019 -
Nrf2 Activation Promotes Lung Cancer Metastasis by Inhibiting the Degradation of
Bach1.
Luca Lignitto, Sarah E LeBoeuf, Harrison Homer, Shaowen Jiang, Manor Askenazi, Triantafyllia R Karakousi, Harvey I Pass, Arjun J Bhutkar, Aristotelis Tsirigos, Beatrix Ueberheide, Volkan I. Sayin, Thales Papagiannakopoulos, Michele Pagano
Cell - 2019 -
Elevated Nrf-2 responses are insufficient to mitigate protein carbonylation in hepatospecific PTEN deletion
mice
Dennis R. Petersen, Laura M. Saba, Volkan I. Sayin, Thales Papagiannakopoulos, Edward E. Schmidt, Gary F. Merrill, David J. Orlicky, Colin T. Shearn
PLoS ONE - 2018 -
Application of CRISPR-mediated genome engineering in cancer
research
Volkan I. Sayin, Thales Papagiannakopoulos
Cancer Letters - 2017 -
Activation of the NRF2 antioxidant program generates an imbalance in central carbon metabolism in
cancer.
Volkan I. Sayin, Sarah E LeBoeuf, Simranjit X Singh, Shawn M Davidson, Douglas Biancur, Betul S Guzelhan, Samantha W Alvarez, Warren L Wu, Triantafyllia R Karakousi, Anastasia Maria Zavitsanou, Julian Ubriaco, Alexander Muir, Dimitris Karagiannis, Patrick J Morris, Craig J Thomas, Richard Possemato, Matthew G Vander Heiden, Thales Papagiannakopoulos
eLife - 2017 -
Keap1 loss promotes Kras-driven lung cancer and results in dependence on
glutaminolysis.
Rodrigo Romero, Volkan I. Sayin, Shawn M Davidson, Matthew R Bauer, Simranjit X Singh, Sarah E LeBoeuf, Triantafyllia R Karakousi, Donald C Ellis, Arjun Bhutkar, Francisco J Sánchez-Rivera, Lakshmipriya Subbaraj, Britney Martinez, Roderick T Bronson, Justin R Prigge, Edward E Schmidt, Craig J Thomas, Chandra Goparaju, Angela Davies, Igor Dolgalev, Adriana Heguy, Viola Allaj, John T Poirier, Andre L Moreira, Charles M Rudin, Harvey I Pass, Matthew G Vander Heiden, Tyler Jacks, Thales Papagiannakopoulos
Nature medicine - 2017 -
Pan-cancer transcriptomic analysis associates long non-coding RNAs with key mutational driver
events
Arghavan Ashouri, Volkan I. Sayin, Jimmy Van den Eynden, S. X. Singh, T. Papagiannakopoulos, Erik Larsson
Nature Communications - 2016 -
Targeting Zfp148 activates p53 and reduces tumor initiation in the
gut
Anna Nilton, Volkan I. Sayin, Zhiyuan V. Zou, Sama I. Sayin, Cecilia Bondjers, Nadia Gul, Pia Ågren, Per Fogelstrand, Ola Nilsson, Martin O. Bergö, Per Lindahl
OncoTarget - 2016 -
Oncogene-induced senescence underlies the mutual exclusive nature of oncogenic KRAS and
BRAF
Jaroslaw Cisowski, Volkan I. Sayin, Meng Liu, C. Karlsson, Martin Bergö
Oncogene - 2016 -
Antioxidants can increase melanoma metastasis in
mice.
Kristell Le Gal, Mohamed X Ibrahim, Clotilde Wiel, Volkan I. Sayin, Murali K Akula, Christin Karlsson, Martin Dalin, Levent Akyürek, Per Lindahl, Jonas A Nilsson, Martin Bergö
Science Translational Medicine - 2015 -
Antioxidants accelerate lung cancer progression in
mice.
Volkan I. Sayin, Mohamed X Ibrahim, Erik Larsson, Jonas A Nilsson, Per Lindahl, Martin Bergö
Science translational medicine - 2014 -
Pathophysiological impact of targeting the ROS-p53
axis
Volkan I. Sayin
2014 -
Loss of One Copy of Zfp148 Reduces Lesional Macrophage Proliferation and Atherosclerosis in Mice by Activating
p53
Volkan I. Sayin, Omar M. Khan, Lara Pehlivanoglu, Anna Staffas, Mohamed X Ibrahim, Annika Asplund, Pia Ågren, Anna Nilton, Göran Bergström, Martin Bergö, Jan Borén, Per Lindahl
Circulation Research - 2014 -
Zfp148 Deficiency Causes Lung Maturation Defects and Lethality in Newborn Mice That Are Rescued by Deletion of p53 or Antioxidant
Treatment
Volkan I. Sayin, Anna Nilton, Mohamed X Ibrahim, Pia Ågren, Erik Larsson, Marleen MR Petit, Lillemor Mattsson Hultén, Marcus Ståhlman, Bengt R Johansson, Martin Bergö, Per Lindahl
Plos One - 2013 -
Zinc Finger Protein 148 Is Dispensable for Primitive and Definitive Hematopoiesis in
Mice
Anna Nilton, Volkan I. Sayin, Anna Staffas, Erik Larsson, Julia Rolf, Marleen MR Petit, Lars Palmqvist, Birgitta Swolin, Susanna Cardell, Per Lindahl
Plos One - 2013
Fler publikationer
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