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- Lillemor Mattsson Hulten
Lillemor Mattsson Hulten
Om Lillemor Mattsson Hulten
Lillemor Mattsson Hultén är anknuten till forskning fd adjungerad professor i hjärt-och kärlforskning med särskild inriktning mot biomarkörer och inflammation vid avd. för molekylär och klinisk medicin, Institutionen för Medicin, Göteborgs Universitet, och är anställd som 1:e kemist vid Sahlgrenska Universitetssjukhuset, Västra Götalandsregionen.
Forskningsområde
Lillemor Mattsson Hultén forskar om hur syrebrist påverkar utvecklingen av åderförkalkning och hjärt-kärlsjukdom. Målet är att finna biomarkörer som kan användas för monitorering av syrebrist, sjukdomsprogression och utvärdering av farmakologisk intervention.
Aktuell forskning: Patofysiologiska mekanismer vid hjärtsvikt och ischemisk hjärtsjukdom hos människa
Forskningsprojektets syfte är att karakterisera cellulära mekanismer i human vävnad från patienter med hjärtsvikt och ischemisk hjärtsjukdom. Det långsiktiga syftet är att kartlägga cellers patofysiologiska betydelse vid hjärtsjukdom samt att om möjligt identifiera diagnostiska och terapeutiska angreppspunkter.
Gruppmedlemmar
- Mikael Sandstedt
- Aditi Chaudhari
- Joakim Sandstedt
- Victoria Rotter Sopasakis
Finansiärer
Hjärt-Lungfonden, Vetenskapsrådet, ALF-medel.
Nyckelpublikationer
- Rotter Sopasakis V, Sandstedt J, Johansson M, Lundqvist A, Bergström G, Jeppsson A, Mattsson Hultén L. Toll-like receptor-mediated inflammation markers are strongly induced in heart tissue in patients with cardiac disease under both ischemic and non-ischemic conditions. International Journal of Cardiology 2019, 293; 238–247.
- Joakim Sandstedt, Kristina Vukusic, Elham Rekabdar, Göran Dellgren, Anders Jeppsson, Lillemor Mattsson Hultén, Victoria Rotter Sopasakis. Markedly reduced myocardial expression of γ-protocadherins and long non-coding RNAs in patients with heart disease. International journal of cardiology - 2021
- Joakim Sandstedt, Kristina Vukusic, Göran Dellgren, Anders Jeppsson, Lillemor Mattsson Hultén, Victoria Rotter Sopasakis. Metagenomic sequencing of human cardiac tissue reveals Microbial RNA which correlates with Toll-like receptor-associated inflammation in patients with heart disease Scientific Reports - 2023
- Aditi Chaudhari, Camila Axelsson, Lillemor Mattsson Hultén, Victoria Rotter Sopasakis. Toll-like Receptors 1, 3 and 7 Activate Distinct Genetic Features of NF-κB Signaling and γ-Protocadherin Expression in Human Cardiac Fibroblasts . INFLAMMATION - 2025
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Toll-like Receptors 1, 3 and 7 Activate Distinct Genetic Features of NF-κB Signaling and γ-Protocadherin Expression in Human Cardiac
Fibroblasts
Aditi Chaudhari, Camila Axelsson, Lillemor Mattsson Hultén, Victoria Rotter Sopasakis
INFLAMMATION - 2025 -
Machine learning evaluation for identification of M-proteins in human
serum
Alexandros Sopasakis, Maria Nilsson, Mattias Askenmo, Fredrik Nyholm, Lillemor Mattsson Hultén, Victoria Rotter Sopasakis
PLoS ONE - 2024 -
Salivary biglycan-neo-epitope-BGN262: A novel surrogate biomarker for equine osteoarthritic sub-chondral bone sclerosis and to monitor the effect of short-term training and surface
arena.
S Adepu, M Lord, Z Hugoh, Susanne Nyström, Lillemor Mattsson Hultén, K Abrahamsson-Aurell, C Lützelschwab, E Skiöldebrand
Osteoarthritis and cartilage open - 2023 -
Regional transcriptomic profiling reveals immune system enrichment in nonfailing atria and all chambers of the failing human
heart
Mikael Sandstedt, Kristina Vukusic, Markus Johansson, Marianne Jonsson, Rasmus Magnusson, Lillemor Mattsson Hultén, Göran Dellgren, Anders Jeppsson, Anders Lindahl, Jane Synnergren, Joakim Sandstedt
American journal of physiology. Heart and circulatory physiology - 2023 -
Metagenomic sequencing of human cardiac tissue reveals Microbial RNA which correlates with Toll-like receptor-associated inflammation in patients with heart
disease
Joakim Sandstedt, Kristina Vukusic, Göran Dellgren, Anders Jeppsson, Lillemor Mattsson Hultén, Victoria Rotter Sopasakis
Scientific Reports - 2023 -
Sex difference in circulating soluble form of ACE2 protein in moderate and severe COVID-19 and healthy
controls.
Josefina Robertson, Bengt Nellgård, Lillemor Mattsson Hultén, Staffan Nilsson, Keti Dalla, Mats Börjesson, Henrik Zetterberg, Joar Svanvik, Magnus Gisslén
Frontiers in medicine - 2022 -
Human intracardiac SSEA4+CD34 cells show features of cycling, immature cardiomyocytes and are distinct from Side Population and C-kit+CD45-
cells
Mikael Sandstedt, Kristina Vukusic, B. Ulfenborg, Marianne Jonsson, Lillemor Mattsson Hultén, Göran Dellgren, Anders Jeppsson, J. Synnergren, Joakim Sandstedt
PLoS ONE - 2022 -
Sex difference in circulating sACE2 protein in moderate and severe COVID-19 and healthy
controls.
Josefina Robertson, Bengt Nellgård, Lillemor Mattsson Hultén, Staffan Nilsson, Keti Dalla, Mats Börjesson, Henrik Zetterberg, Joar Svanvik, Magnus Gisslén
Frontiers in medicine - 2022 -
COMP (Cartilage Oligomeric Matrix Protein) Neoepitope: A Novel Biomarker to Identify Symptomatic Carotid
Stenosis
Joakim Sandstedt, Karin Vargmar, K. Björkman, Ulla Ruetschi, Göran Bergström, Lillemor Mattsson Hultén, E. Skiöldebrand
Arteriosclerosis, thrombosis, and vascular biology - 2021 -
Nerve growth factor in the equine
joint
A. Kendall, S. Ekman, Lillemor Mattsson Hultén, A. Lindahl, Elisabeth Hansson, E. Skioldebrand
Veterinary Journal - 2021 -
Markedly reduced myocardial expression of γ-protocadherins and long non-coding RNAs in patients with heart
disease.
Joakim Sandstedt, Kristina Vukusic, Elham Rekabdar, Göran Dellgren, Anders Jeppsson, Lillemor Mattsson Hultén, Victoria Rotter Sopasakis
International journal of cardiology - 2021 -
Wide QRS-T angles are associated with markers of increased inflammatory activity independently of hypertension and
diabetes.
Mikael Sandstedt, Lennart Bergfeldt, Joakim Sandstedt, Annika Lundqvist, Emanuel Fryk, Per-Anders Jansson, Göran Bergström, Lillemor Mattsson Hultén
Annals of noninvasive electrocardiology : the official journal of the International Society for Holter and Noninvasive Electrocardiology, Inc - 2020 -
Galectin-1 is inversely associated with type 2 diabetes independently of obesity – A SCAPIS pilot
study.
Emanuel Fryk, Lena Strindberg, Annika Lundqvist, Mikael Sandstedt, Lennart Bergfeldt, Lillemor Mattsson Hultén, Göran Bergström, Per-Anders Jansson
Metabolism Open - 2019 -
Effect of circadian rhythm, age, training and acute lameness on serum concentrations of cartilage oligomeric matrix protein (COMP) neo-epitope in
horses
S. Ekman, Anders Lindahl, Ulla Ruetschi, A. Jansson, K. Bjorkman, K. Abrahamsson-Aurell, S. Bjornsdottir, M. Lofgren, Lillemor Mattsson Hultén, Eva Skiöldebrand
Equine Veterinary Journal - 2019 -
Human cardiac fibroblasts isolated from patients with severe heart failure are immune-competent cells mediating an inflammatory
response.
Joakim Sandstedt, Mikael Sandstedt, Annika Lundqvist, Märta Jansson, Victoria Rotter Sopasakis, Anders Jeppsson, Lillemor Mattsson Hultén
Cytokine - 2019 -
Toll-like receptor-mediated inflammation markers are strongly induced in heart tissue in patients with cardiac disease under both ischemic and non-ischemic
conditions.
Victoria Rotter Sopasakis, Joakim Sandstedt, Michaela Johansson, Annika Lundqvist, Göran Bergström, Anders Jeppsson, Lillemor Mattsson Hultén
International journal of cardiology - 2019 -
Hypoxic cardiac fibroblasts from failing human hearts decrease cardiomyocyte beating frequency in an ALOX15 dependent
manner
Mikael Sandstedt, Victoria Rotter Sopasakis, Annika Lundqvist, Kristina Vukusic, Anders Oldfors, Göran Dellgren, Joakim Sandstedt, Lillemor Mattsson Hultén
Plos One - 2018 -
Vimentin deficiency in macrophages induces increased oxidative stress and vascular inflammation but attenuates atherosclerosis in
mice
Liliana Håversen, J. P. Sundelin, A. Mardinoglu, Mikael Rutberg, Marcus Ståhlman, Ulrika Wilhelmsson, Lillemor Mattsson Hultén, Milos Pekny, Per Fogelstrand, J. F. Bentzon, Malin Levin, Jan Borén
Scientific Reports - 2018 -
Cartilage oligomeric matrix protein neoepitope in the synovial fluid of horses with acute lameness: A new biomarker for the early stages of
osteoarthritis
Eva Skiöldebrand, S. Ekman, Lillemor Mattsson Hultén, Emilia Svala, K. Bjorkman, Anders Lindahl, A. Lundqvist, P. Onnerfjord, Carina Sihlbom, Ulla Ruetschi
Equine Veterinary Journal - 2017 -
Inflammatory activation of human cardiac fibroblasts leads to altered calcium signaling, decreased connexin 43 expression and increased glutamate
secretion
Eva Skiöldebrand, Annika Lundqvist, Ulrika Björklund, Mikael Sandstedt, Anders Lindahl, Elisabeth Hansson, Lillemor Mattsson Hultén
Heliyon - 2017 -
Deficiency in perilipin 5 reduces mitochondrial function and membrane depolarization in mouse
hearts.
Linda Andersson, Christina Drevinge, Ismena Mardani, Knut T Dalen, Marcus Ståhlman, Martina Klevstig, Annika Lundqvist, Fred Haugen, Martin Adiels, Per Fogelstrand, Jorge Asin-Cayuela, Lillemor Mattsson Hultén, Max Levin, Ewa Ehrenborg, Yun K Lee, Alan R Kimmel, Jan Borén, Malin Levin
The international journal of biochemistry & cell biology - 2017 -
The variation in free 25-hydroxy vitamin D and vitamin D-binding protein with season and vitamin D
status.
Göran Oleröd, Lillemor Mattsson Hultén, Ola Hammarsten, Eva Klingberg
Endocrine connections - 2017 -
The Arachidonate 15-Lipoxygenase Enzyme Product 15-HETE Is Present in Heart Tissue from Patients with Ischemic Heart Disease and Enhances Clot
Formation
Annika Lundqvist, Mikael Sandstedt, Joakim Sandstedt, Ruth Wickelgren, G. I. Hansson, Anders Jeppsson, Lillemor Mattsson Hultén
Plos One - 2016 -
Postprandial effects of the phosphodiesterase-5 inhibitor tadalafil in people with well-controlled Type 2 diabetes mellitus: a randomized controlled
trial.
Lovisa Sjögren, Josefin Olausson, Lena Strindberg, Reza Mobini, Per Fogelstrand, Lillemor Mattsson Hultén, Per-Anders Jansson
Diabetic medicine : a journal of the British Diabetic Association - 2016 -
Perilipin 5 is protective in the ischemic
heart
Christina Drevinge, K. T. Dalen, M. N. Mannila, Margareta Scharin Täng, Marcus Ståhlman, Martina Klevstig, Annika Lundqvist, Ismena Mardani, F. Haugen, Per Fogelstrand, Martin Adiels, Jorge Asin-Cayuela, C. Ekestam, J. R. Gadin, Y. K. Lee, H. Nebb, Sara Svedlund, Bengt R Johansson, Lillemor Mattsson Hultén, Stefano Romeo, Björn Redfors, Elmir Omerovic, Max Levin, Li-Ming Gan, P. Eriksson, Linda Andersson, E. Ehrenborg, A. R. Kimmel, Jan Borén, Malin Levin
International Journal of Cardiology - 2016 -
Cadmium exposure as measured in blood in relation to macrophage density in symptomatic atherosclerotic plaques from human carotid
artery
Björn Fagerberg, Josefin Kjelldahl, Gerd Sällsten, Lars Barregård, N. Forsgard, Klas Österberg, Lillemor Mattsson Hultén, Göran Bergström
Atherosclerosis - 2016 -
Imaging of Intracellular and Extracellular ROS Levels in Atherosclerotic Mouse Aortas Ex Vivo: Effects of Lipid Lowering by Diet or
Atorvastatin
Matias Ekstrand, Maria Gustafsson Trajkovska, Jeanna Perman Sundelin, Per Fogelstrand, Martin Adiels, M. Johansson, Lillemor Mattsson Hultén, Jan Borén, Max Levin
Plos One - 2015 -
Oregonin reduces lipid accumulation and proinflammatory responses in primary human
macrophages
Annika Lundqvist, Lisa U. Magnusson, Christina Ullström, J. Krasilnikova, G. Telysheva, T. Dizhbite, Lillemor Mattsson Hultén
Biochemical and Biophysical Research Communications - 2015 -
Lp(a) is not associated with diabetes but affects fibrinolysis and clot structure ex
vivo
Marianne Månsson, I. Kalies, Göran Bergström, Caroline Schmidt, A. Legnehed, Lillemor Mattsson Hultén, L. Amrot-Fors, D. Gustafsson, W. Knecht
Scientific Reports - 2014 -
Macrophage CD14 expression in human carotid plaques is associated with complicated lesions, correlates with thrombosis, and is reduced by angiotensin receptor blocker
treatment
Cecilia Hermansson, Annika Lundqvist, Lisa U. Magnusson, Christina Ullström, Göran Bergström, Lillemor Mattsson Hultén
International Immunopharmacology - 2014 -
Arachidonate 15-Lipoxygenase Enzyme Products Increase Platelet Aggregation and Thrombin
Generation
C. Vijil, Cecilia Hermansson, Anders Jeppsson, Göran Bergström, Lillemor Mattsson Hultén
Plos One - 2014 -
Adenosine prevents isoprenaline-induced cardiac contractile and electrophysiological
dysfunction.
Yangzhen Shao, Björn Redfors, Lillemor Mattsson Hultén, Margareta Scharin Täng, Elma Daryoni, Mohammed Said, Elmir Omerovic
European journal of pharmacology - 2013 -
Zfp148 Deficiency Causes Lung Maturation Defects and Lethality in Newborn Mice That Are Rescued by Deletion of p53 or Antioxidant
Treatment
Volkan I. Sayin, Anna Nilton, Mohamed X Ibrahim, Pia Ågren, Erik Larsson, Marleen MR Petit, Lillemor Mattsson Hultén, Marcus Ståhlman, Bengt R Johansson, Martin Bergö, Per Lindahl
Plos One - 2013 -
Reduced expression of NLRP3 and MEFV in human ischemic heart
tissue.
Cecilia Hermansson, Annika Lundqvist, Carina Wasslavik, Lars Palmqvist, Anders Jeppsson, Lillemor Mattsson Hultén
Biochemical and biophysical research communications - 2013 -
Arachidonate 15-Lipoxygenase Type B Knockdown Leads to Reduced Lipid Accumulation and Inflammation in
Atherosclerosis
Lisa U. Magnusson, Annika Lundqvist, Merja Nurkkala Karlsson, Kristina Skålen, Max Levin, Olov Wiklund, Jan Borén, Lillemor Mattsson Hultén
Plos One - 2012 -
The Importance of GLUT3 for De Novo Lipogenesis in Hypoxia-Induced Lipid Loading of Human
Macrophages
Lu Li, Bo Liu, Liliana Håversen, Emma Lu, Lisa U. Magnusson, Marcus Ståhlman, Jan Borén, Göran Bergström, Malin Levin, Lillemor Mattsson Hultén
Plos One - 2012 -
High expression of arachidonate 15-lipoxygenase and proinflammatory markers in human ischemic heart
tissue
Lisa U. Magnusson, Annika Lundqvist, Julia Asp, J. Synnergren, Cecilia Thalén Johansson, Lars Palmqvist, A. Jeppsson, Lillemor Mattsson Hultén
Biochemical and Biophysical Research Communications - 2012 -
The VLDL receptor promotes lipotoxicity and increases mortality in mice following an acute myocardial
infarction.
Jeanna Perman, Pontus Boström, Malin Lindbom, Ulf Lidberg, Marcus Ståhlman, Daniel Hägg, Henrik Lindskog, Margareta Scharin Täng, Elmir Omerovic, Lillemor Mattsson Hultén, Anders Jeppsson, Petur Petursson, Johan Herlitz, Gunilla Olivecrona, Dudley K Strickland, Kim Ekroos, Sven-Olof Olofsson, Jan Borén
The Journal of clinical investigation - 2011 -
Geranylgeranyltransferase type I (GGTase-I) deficiency hyperactivates macrophages and induces erosive arthritis in
mice.
Omar M. Khan, Mohamed X Ibrahim, Ing-Marie Jonsson, Christin Karlsson, Meng Liu, Anna-Karin Sjögren, Frida J Olofsson, Mikael Brisslert, Sofia E M Andersson, Claes Ohlsson, Lillemor Mattsson Hultén, Maria Bokarewa, Martin Bergö
The Journal of clinical investigation - 2011 -
Hypothermia in cardiogenic shock reduces systemic t-PA
release
J. van der Pals, M. I. Gotberg, M. Gotberg, Lillemor Mattsson Hultén, Mia Magnusson, Sverker Jern, D. Erlinge
Journal of Thrombosis and Thrombolysis - 2011 -
Physical training after percutaneous coronary intervention in patients with stable angina: effects on working capacity, metabolism, and markers of
inflammation
Marco Astengo, Asa Dahl, Thomas Karlsson, Lillemor Mattsson Hultén, Olov Wiklund, Bertil Wennerblom
European Journal of Cardiovascular Prevention & Rehabilitation - 2010 -
Interleukin-18 as a Predictor of Future Events in Patients With Acute Coronary
Syndromes.
Marianne Hartford, Olov Wiklund, Lillemor Mattsson Hultén, Anita Persson, Thomas Karlsson, Johan Herlitz, Johannes Hulthe, Kenneth Caidahl
Arteriosclerosis, thrombosis, and vascular biology - 2010 -
15-Lipoxygenase-2 is expressed in macrophages in human carotid plaques and regulated by hypoxia-inducible factor-1
alpha
Lillemor Mattsson Hultén, Fredrik J. Olson, Hanna Åberg, Jonas Carlsson, Lars Karlström, Jan Borén, Björn Fagerberg, Olov Wiklund
European Journal of Clinical Investigation - 2010 -
Hypoxic regulation of secreted proteoglycans in
macrophages.
Annika Asplund, Pia Stillemark-Billton, Erik Larsson, Ellen Knutsen Rydberg, Jonatan Moses, Lillemor Mattsson Hultén, Björn Fagerberg, German Camejo, Göran Bondjers
Glycobiology - 2010 -
Myocardial release of FKBP12 and increased production of FKBP12.6 in ischemia and reperfusion experimental
models
Karin Åström-Olsson, Lars O Karlsson, Lillemor Mattsson Hultén, Pia Davidsson, Vittorio Mantovani, Chrichan Månsson, Sven-Olof Olofsson, Olov Wiklund, Lars Grip
Biochem Biophys Res Commun - 2009 -
The role of hypoxia in
atherosclerosis
Lillemor Mattsson Hultén, Max Levin
Current Opinion in Lipidology - 2009 -
ApoCIII-Enriched LDL in Type 2 Diabetes Displays Altered Lipid Composition, Increased Susceptibility for Sphingomyelinase and Increased binding to
Biglycan.
A Hiukka, Marcus Ståhlman, Camilla Pettersson, Malin Levin, Martin Adiels, Susann Teneberg, ES Leinonen, Lillemor Mattsson Hultén, Olov Wiklund, M Oresic, Sven-Olof Olofsson, MR Taskinen, K Ekroos, Jan Borén
Diabetes - 2009 -
Possible mechanisms for the anti-atherogenic effect of the estradiol metabolite
2-methoxyestradiol
Johan Bourghardt Fagman, Lillemor Mattsson Hultén, Sara Sjöberg, Alexandra Krettek, Åsa Tivesten
14th Annual Scandinavian Atheroclserosis Conference, Humlebæk, Denmark - 2008 -
Long-term effects of fenofibrate on carotid intima-media thickness and augmentation index in subjects with type 2 diabetes
mellitus.
Anne Hiukka, Jukka Westerbacka, Eeva S Leinonen, Hiroshi Watanabe, Olov Wiklund, Lillemor Mattsson Hultén, Jukka T Salonen, Tomi-Pekka Tuomainen, Hannele Yki-Järvinen, Anthony C Keech, Marja-Riitta Taskinen
Journal of the American College of Cardiology - 2008 -
15-Lipoxygenase-2 expression in human macrophages induces chemokine secretion and T cell
migration.
Kristina Danielsson Norén, Ellen Rydberg Knutsen, Madeleine Ingelsten, Levent Akyürek, Pernilla Jirholt, Christina Ullström, Gun-Britt Forsberg, Jan Borén, Olov Wiklund, Lillemor Mattsson Hultén
Atherosclerosis - 2008
Fler publikationer
Antalet publikationer som visas på denna sida är begränsat. Besök Göteborgs Universitets publikationsdatabas (GUP) för att söka efter fler publikationer.