Ingrid Wernstedt Asterholm
Om Ingrid Wernstedt Asterholm
Det övergripande syftet med vår forskning är att undersöka kopplingen mellan övervikt/fetma och ökad risk för typ-2 diabetes och cancer.
Vi är framförallt intresserade av att undersöka om och hur fettcellernas funktion påverkar metabola och immunologiska processer lokalt i fettväven, och huruvida dessa effekter i sin tur bidrar eller skyddar mot det metabola syndromet och/eller tumörtillväxt.
För mer information om vår forskning se IWA-labbets hemsida
Undervisning: Metabolism, forskningsmetodik
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Comparing lipid remodeling of brown adipose tissue, white adipose tissue, and liver after one-week high fat diet intervention with quantitative Raman
microscopy
A. Paul, Belén Chanclón, Cecilia Brännmark, P. Wittung-Stafshede, Charlotta S Olofsson, Ingrid Wernstedt Asterholm, S. H. Parekh
Journal of Cellular Biochemistry - 2023 -
Adipocyte-specific ablation of the Ca2+ pump SERCA2 impairs whole-body metabolic function and reveals the diverse metabolic flexibility of white and brown adipose
tissue.
Marco Bauzá-Thorbrügge, Elin Banke, Belén Chanclón, Eduard Peris, Yanling Wu, Musovic Saliha, Cecilia Jönsson, Peter Strålfors, Patrik Rorsman, Charlotta S Olofsson, Ingrid Wernstedt Asterholm
Molecular metabolism - 2022 -
Adiponectin Deficiency Alters Placenta Function but Does Not Affect Fetal Growth in
Mice
Man Mohan Shrestha, Sanne Wermelin, E. Stener-Victorin, Ingrid Wernstedt Asterholm, Anna Benrick
International Journal of Molecular Sciences - 2022 -
Noradrenaline and ATP regulate adiponectin exocytosis in white adipocytes: Disturbed adrenergic and purinergic signalling in obese and insulin-resistant
mice
Musovic Saliha, Ali Komai, Marina Kalds Said, Man Mohan Shrestha, Yanling Wu, Ingrid Wernstedt Asterholm, Charlotta S Olofsson
Molecular and Cellular Endocrinology - 2022 -
Deficient Caveolin-1 Synthesis in Adipocytes Stimulates Systemic Insulin-Independent Glucose Uptake via Extracellular
Vesicles
C. Crewe, S. Chen, D. Bu, C. M. Gliniak, Ingrid Wernstedt Asterholm, X. X. Yu, N. Joffin, C. O. de Souza, J. B. Funcke, D. Y. Oh, O. Varlamov, J. J. Robino, R. Gordillo, P. E. Scherer
Diabetes - 2022 -
C1QTNF3 is Upregulated During Subcutaneous Adipose Tissue Remodeling and Stimulates Macrophage Chemotaxis and M1-Like
Polarization
Peter Micallef, Milica Vujičić, Yanling Wu, Eduard Peris, Ying Wang, Belén Chanclón, Anders Ståhlberg, Susanna Cardell, Ingrid Wernstedt Asterholm
Frontiers in Immunology - 2022 -
Sex and Species Differences in the Development of Diet-Induced Obesity and Metabolic Disturbances in
Rodents.
Ivana Maric, Jean-Philippe Krieger, Pauline van der Velden, Stina Börchers, Mohammed Asker, Milica Vujičić, Ingrid Wernstedt Asterholm, Karolina P Skibicka
Frontiers in nutrition - 2022 -
Acute fat loss does not affect bone
mass
Marie K Lagerquist, Karin L. Gustafsson, Petra Henning, Helen H. Farman, Jianyao Wu, Klara Sjögren, A. Koskela, J. Tuukkanen, Claes Ohlsson, Ingrid Wernstedt Asterholm, Louise Grahnemo
Scientific Reports - 2021 -
Arginine-vasopressin mediates counter-regulatory glucagon release and is diminished in type 1
diabetes.
Angela Kim, Jakob G Knudsen, Joseph C Madara, Anna Benrick, Thomas G Hill, Lina Abdul Kadir, Joely A Kellard, Lisa J. Mellander, Caroline Miranda, Haopeng Lin, Timothy James, Kinga Suba, Aliya F Spigelman, Yanling Wu, Patrick E MacDonald, Ingrid Wernstedt Asterholm, Tore Magnussen, Mikkel Christensen, Tina Vilsbøll, Victoria Salem, Filip K Knop, Patrik Rorsman, Bradford B Lowell, Linford Jb Briant
eLife - 2021 -
Adipose Tissue-Breast Cancer Crosstalk Leads to Increased Tumor Lipogenesis Associated with Enhanced Tumor
Growth.
Peter Micallef, Yanling Wu, Marco Bauzá-Thorbrügge, Belén Chanclón, Milica Vujičić, Eduard Peris, C. Joakim Ek, Ingrid Wernstedt Asterholm
International journal of molecular sciences - 2021 -
Maternal adiponectin prevents visceral adiposity and adipocyte hypertrophy in prenatal androgenized female
mice
Yanling Wu, Belén Chanclón, Peter Micallef, E. Stener-Victorin, Ingrid Wernstedt Asterholm, Anna Benrick
FASEB Journal - 2021 -
Somatostatin secretion by Na+-dependent Ca2+-induced Ca2+ release in pancreatic
delta-cells.
Elisa Vergari, Geoffrey Denwood, Albert Salehi, Quan Zhang, Julie Adam, Ahmed Alrifaiy, Ingrid Wernstedt Asterholm, Anna Benrick, Margarita V Chibalina, Lena Eliasson, Claudia Guida, Thomas G Hill, Alexander Hamilton, Reshma Ramracheya, Frank Reimann, Nils J G Rorsman, Ioannis Spilliotis, Andrei I Tarasov, Jonathan N Walker, Patrik Rorsman, Linford J B Briant
Nature metabolism - 2020 -
Peripancreatic adipose tissue protects against high-fat-diet-induced hepatic steatosis and insulin resistance in
mice
Belén Chanclón, Yanling Wu, Milica Vujičić, Marco Bauzá-Thorbrügge, Elin Banke, Peter Micallef, Julia Kanerva, Björn Wilder, Patrik Rorsman, Ingrid Wernstedt Asterholm
International Journal of Obesity - 2020 -
Adiponectin is secreted via caveolin 1-dependent mechanisms in white
adipocytes
Cecilia Brännmark, Emma I. Kay, U. O. Kugelberg, Belén Chanclón, Man Mohan Shrestha, Ingrid Wernstedt Asterholm, P. Stralfors, Charlotta S Olofsson
Journal of Endocrinology - 2020 -
Suppressing adipocyte inflammation promotes insulin resistance in
mice
Q. Zhu, Y. A. An, M. Kim, Z. Zhang, S. Zhao, Y. Zhu, Ingrid Wernstedt Asterholm, C. M. Kusminski, P. E. Scherer
Molecular Metabolism - 2020 -
Parabrachial Interleukin-6 Reduces Body Weight and Food Intake and Increases Thermogenesis to Regulate Energy
Metabolism
Devesh Mishra, Jennifer E. Richard, Ivana Maric, B. Porteiro, M. Haring, S. Kooijman, Musovic Saliha, Kim Eerola, Lorena Lopez-Ferreras, Eduard Peris, Katarzyna Grycel, Olesya Shevchouk, Peter Micallef, Charlotta S Olofsson, Ingrid Wernstedt Asterholm, H. J. Grill, R. Nogueiras, Karolina P Skibicka
Cell Reports - 2019 -
Antioxidant treatment induces reductive stress associated with mitochondrial dysfunction in
adipocytes
Eduard Peris, Peter Micallef, A. Paul, Vilborg Palsdottir, A. Enejder, Marco Bauzá-Thorbrügge, Charlotta S Olofsson, Ingrid Wernstedt Asterholm
Journal of Biological Chemistry - 2019 -
Dysregulation of amyloid precursor protein impairs adipose tissue mitochondrial function and promotes
obesity
Y. A. An, C. Crewe, Ingrid Wernstedt Asterholm, K. Sun, S. W. Chen, F. Zhang, M. L. Shao, J. B. Funcke, Z. Z. Zhang, L. Straub, J. Yoshino, S. Klein, C. M. Kusminski, P. E. Scherer
Nature Metabolism - 2019 -
Insulin inhibits glucagon release by SGLT2-induced stimulation of somatostatin
secretion
E. Vergari, J. G. Knudsen, R. Ramracheya, Albert Salehi, Q. Zhang, J. Adam, Ingrid Wernstedt Asterholm, Anna Benrick, L. J. B. Briant, M. V. Chibalina, F. M. Gribble, A. Hamilton, B. Hastoy, F. Reimann, N. J. G. Rorsman, II Spiliotis,, A. Tarasov, Yanling Wu, Frances M. Ashcroft, Patrik Rorsman
Nature Communications - 2019 -
Increased bone mass in a mouse model with low fat
mass.
Louise Grahnemo, Karin L. Gustafsson, Klara Sjögren, Petra Henning, Vikte Lionikaite, Antti Koskela, Juha Tuukkanen, Claes Ohlsson, Ingrid Wernstedt Asterholm, Marie Lagerquist
American journal of physiology. Endocrinology and metabolism - 2018 -
Glucagon-Like Peptide 1 and Its Analogs Act in the Dorsal Raphe and Modulate Central Serotonin to Reduce Appetite and Body
Weight
Rozita H Anderberg, Jennifer E. Richard, Kim Eerola, Lorena López-Ferreras, Elin Banke, Caroline Hansson, Hans Nissbrandt, Filip Bergquist, F. M. Gribble, F. Reimann, Ingrid Wernstedt Asterholm, C. M. Lamy, Karolina P Skibicka
Diabetes - 2017 -
CNS beta(3)-adrenergic receptor activation regulates feeding behavior, white fat browning, and body
weight
Jennifer E. Richard, Lorena López-Ferreras, Belén Chanclón, Kim Eerola, Peter Micallef, Karolina P Skibicka, Ingrid Wernstedt Asterholm
American Journal of Physiology-Endocrinology and Metabolism - 2017 -
Adiponectin protects against development of metabolic disturbances in a PCOS mouse
model
Anna Benrick, Belén Chanclón, Peter Micallef, Yanling Wu, Laila Hadi, J. M. Shelton, Elisabet Stener-Victorin, Ingrid Wernstedt Asterholm
Proceedings of the National Academy of Sciences of the United States of America - 2017 -
Protein kinase STK25 aggravates the severity of non-alcoholic fatty pancreas disease in
mice
Esther Nuñez Durán, Belén Chanclón, Silva Sütt, Joana Real, Hanns-Ulrich Marschall, Ingrid Wernstedt Asterholm, Emmelie Cansby, Margit Mahlapuu
Journal of Endocrinology - 2017 -
Six Tissue Transcriptomics Reveals Specific Immune Suppression in Spleen by Dietary Polyunsaturated Fatty
Acids
Sara L Svahn, Leif Väremo, Britt G. Gabrielsson, Eduard Peris, Intawat Nookaew, Louise Grahnemo, Ann-Sofie Sandberg, Ingrid Wernstedt Asterholm, John-Olov Jansson, Jens B. Nielsen, Maria E Johansson
PLoS ONE - 2016 -
Pathological Type-2 Immune Response, Enhanced Tumor Growth, and Glucose Intolerance in Retn/beta (RELM beta) Null Mice A Model of Intestinal Immune System Dysfunction in Disease
Susceptibility
Ingrid Wernstedt Asterholm, J. Y. Kim-Muller, J. M. Rutkowski, C. Crewe, C. Tao, P. E. Scherer
American Journal of Pathology - 2016 -
White Adipocyte Adiponectin Exocytosis Is Stimulated via beta(3)-Adrenergic Signaling and Activation of Epac1: Catecholamine Resistance in Obesity and Type 2
Diabetes
Ali Komai, Musovic Saliha, Eduard Peris, Ahmed Alrifaiy, Michael El Hachmane, Marcus Johansson, Ingrid Wernstedt Asterholm, Charlotta S Olofsson
Diabetes - 2016 -
Fibrosis-streaks and splatters: Some things are not always what they seem to
be.
Ingrid Wernstedt Asterholm, Philipp E Scherer
Obesity (Silver Spring, Md.) - 2016 -
Maternal Adiponectin Controls Milk Composition to Prevent Neonatal
Inflammation.
Zixue Jin, Yang Du, Adam G Schwaid, Ingrid Wernstedt Asterholm, Philipp E Scherer, Alan Saghatelian, Yihong Wan
Endocrinology - 2015 -
Structure-guided Development of Specific Pyruvate Dehydrogenase Kinase Inhibitors Targeting the ATP-binding
Pocket.
Shih-Chia Tso, Xiangbing Qi, Wen-Jun Gui, Cheng-Yang Wu, Jacinta L Chuang, Ingrid Wernstedt Asterholm, Lorraine K Morlock, Kyle R Owens, Philipp E Scherer, Noelle S Williams, Uttam K Tambar, R Max Wynn, David T Chuang
The Journal of biological chemistry - 2014 -
Adipocyte inflammation is essential for healthy adipose tissue expansion and
remodeling.
Ingrid Wernstedt Asterholm, Caroline Tao, Thomas S Morley, Qiong A Wang, Fernando Delgado-Lopez, Zhao V Wang, Philipp E Scherer
Cell metabolism - 2014 -
Elevated resistin levels induce central leptin resistance and increased atherosclerotic progression in
mice.
Ingrid Wernstedt Asterholm, Joseph M Rutkowski, Teppei Fujikawa, You-Ree Cho, Makoto Fukuda, Caroline Tao, Zhao V Wang, Rana K Gupta, Joel K Elmquist, Philipp E Scherer
Diabetologia - 2014 -
TRAIL (TNF-related apoptosis-inducing ligand) regulates adipocyte metabolism by caspase-mediated cleavage of
PPARgamma.
M Keuper, Ingrid Wernstedt Asterholm, P E Scherer, M-A Westhoff, P Möller, K-M Debatin, G Strauss, M Wabitsch, P Fischer-Posovszky
Cell death & disease - 2013 -
Elevated interlukin-6 levels as a consequence, not the cause of obesity and insulin
resistance
Anna Benrick, Ingrid Wernstedt Asterholm
Interleukin-6: Genetics, Clinical Applications and Role in Disease - 2013 -
Interleukin-6 mediates exercise-induced increase in insulin sensitivity in
mice.
Anna Benrick, Ville Wallenius, Ingrid Wernstedt Asterholm
Experimental physiology - 2012 -
Metabolic jet lag when the fat clock is out of
sync.
Ingrid Wernstedt Asterholm, Philipp E Scherer
Nature medicine - 2012 -
Altered mitochondrial function and metabolic inflexibility associated with loss of
caveolin-1.
Ingrid Wernstedt Asterholm, Dorothy I Mundy, Jian Weng, Richard G W Anderson, Philipp E Scherer
Cell metabolism - 2012 -
Lack of "immunological fitness" during fasting in metabolically challenged
animals.
Ingrid Wernstedt Asterholm, John McDonald, Pierre-Gilles Blanchard, Madhur Sinha, Qiang Xiao, Jehangir Mistry, Joseph M Rutkowski, Yves Deshaies, Rolf A Brekken, Philipp E Scherer
Journal of lipid research - 2012 -
Dichotomous effects of VEGF-A on adipose tissue
dysfunction.
Kai Sun, Ingrid Wernstedt Asterholm, Christine M Kusminski, Ana Carolina Bueno, Zhao V Wang, Jeffrey W Pollard, Rolf A Brekken, Philipp E Scherer
Proceedings of the National Academy of Sciences of the United States of America - 2012 -
Perinatal lack of maternal IL-6 promotes increased adiposity during adulthood in
mice.
Susanne Lager, Ingrid Wernstedt Asterholm, Erik Schéle, Nina Jansson, Staffan Nilsson, John-Olov Jansson, Malin Lönn, Agneta Holmäng
Endocrinology - 2011 -
Targeted deletion of adipocytes by apoptosis leads to adipose tissue recruitment of alternatively activated M2
macrophages.
Pamela Fischer-Posovszky, Qiong A Wang, Ingrid Wernstedt Asterholm, Joseph M Rutkowski, Philipp E Scherer
Endocrinology - 2011 -
Enhanced metabolic flexibility associated with elevated adiponectin
levels.
Ingrid Wernstedt Asterholm, Philipp E Scherer
The American journal of pathology - 2010 -
Rgs16 and Rgs8 in embryonic endocrine pancreas and mouse models of
diabetes.
Alethia Villasenor, Zhao V Wang, Lee B Rivera, Ozhan Ocal, Ingrid Wernstedt Asterholm, Philipp E Scherer, Rolf A Brekken, Ondine Cleaver, Thomas M Wilkie
Disease models & mechanisms - 2010 -
Hypoxia-inducible factor 1alpha induces fibrosis and insulin resistance in white adipose
tissue.
Nils Halberg, Tayeba Khan, Maria E Trujillo, Ingrid Wernstedt Asterholm, Alan D Attie, Shariq Sherwani, Zhao V Wang, Shira Landskroner-Eiger, Sean Dineen, Ulysses J Magalang, Rolf A Brekken, Philipp E Scherer
Molecular and cellular biology - 2009 -
Interleukin-6 gene knockout influences energy balance regulating peptides in the hypothalamic paraventricular and supraoptic
nuclei.
Anna Benrick, Erik Schéle, S B Pinnock, Ingrid Wernstedt Asterholm, Suzanne L. Dickson, Linda Karlsson-Lindahl, John-Olov Jansson
Journal of neuroendocrinology - 2009 -
Joint analysis of individual participants' data from 17 studies on the association of the IL6 variant -174G>C with circulating glucose levels, interleukin-6 levels, and body mass
index.
Cornelia Huth, Thomas Illig, Christian Herder, Christian Gieger, Harald Grallert, Caren Vollmert, Wolfgang Rathmann, Yasmin H Hamid, Oluf Pedersen, Torben Hansen, Barbara Thorand, Christa Meisinger, Angela Doring, Norman Klopp, Henning Gohlke, Wolfgang Lieb, Christian Hengstenberg, Valeriya Lyssenko, Leif Groop, Helen Ireland, Jeffrey W Stephens, Ingrid Wernstedt Asterholm, John-Olov Jansson, Heiner Boeing, Matthias Mohlig, Heather M Stringham, Michael Boehnke, Jaakko Tuomilehto, Jose-Manuel Fernandez-Real, Abel Lopez-Bermejo, Luis Gallart, Joan Vendrell, Steve E Humphries, Florian Kronenberg, H-Erich Wichmann, Iris M Heid
Annals of medicine - 2009 -
The adipocyte as an endocrine
cell.
Nils Halberg, Ingrid Wernstedt Asterholm, Philipp E Scherer
Endocrinology and metabolism clinics of North America - 2008 -
A non-conservative polymorphism in the IL-6 signal transducer (IL6ST)/gp130 is associated with myocardial infarction in a hypertensive
population.
Anna Benrick, Pernilla Jirholt, Ingrid Wernstedt, Maria Gustafsson, Juergen Scheller, Anna-Lena Eriksson, Jan Borén, Thomas Hedner, Claes Ohlsson, Torleif Härd, Stefan Rose-John, John-Olov Jansson
Regulatory peptides - 2008 -
Mouse Models of Lipodystrophy Key reagents for the understanding of the metabolic
syndrome.
Ingrid Wernstedt Asterholm, Nils Halberg, Philipp E Scherer
Drug discovery today. Disease models - 2007 -
Mature-onset obesity in interleukin-1 receptor I knockout
mice.
Maria C García, Ingrid Wernstedt, Anna Berndtsson, Maria Enge, Michal Bell, Olof H. Hultgren, Michael Horn, Bo Ahrén, Sven Enerbäck, Claes Ohlsson, Ville Wallenius, John-Olov Jansson
Diabetes - 2006 -
Increased levels of acylation-stimulating protein in interleukin-6-deficient (IL-6(-/-))
mice
Ingrid Wernstedt, Bob Olsson, Margareta Jernås, S. Paglialunga, Lena M S Carlsson, Ulf Smith, K. Cianflone, Kristina Wallenius, Ville Wallenius
Endocrinology - 2006 -
Reduced stress- and cold-induced increase in energy expenditure in interleukin-6-deficient
mice.
Ingrid Wernstedt, Amanda Edgley, Anna Berndtsson, Jenny Fäldt, Göran Bergström, Ville Wallenius, John-Olov Jansson
American journal of physiology. Regulatory, integrative and comparative physiology - 2006 -
Leukemia inhibitory factor reduces body fat mass in ovariectomized
mice
John-Olov Jansson, Sofia Movérare-Skrtic, Anna Berndtsson, Ingrid Wernstedt, Hans Carlsten, Claes Ohlsson
Eur J Endocrinol - 2006 -
IL6 gene promoter polymorphisms and type 2 diabetes - Joint analysis of individual participants' data from 21
studies
Cornelia Huth, Iris M. Heid, Caren Vollmert, Christian Gieger, Harald Grallert, Johanna K. Wolford, Birgit Langer, Barbara Thorand, Norman Klopp, Yasmin H. Hamid, Oluf Pedersen, Torben Hansen, Valeriya Lyssenko, Leif Groop, Christa Meisinger, Angela Do?ring, Hannelore Lo?wel, Wolfgang Lieb, Christian Hengstenberg, Wolfgang Rathmann, Stephan Martin, Jeffrey W. Stephens, Helen Ireland, Hugh Mather, George J. Miller, Heather M. Stringham, Michael Boehnke, Jaakko Tuomilehto, Heiner Boeing, Matthias Mo?hlig, Joachim Spranger, Andreas Pfeiffer, Ingrid Wernstedt, Anders Niklason, Abel Lo?pez-Bermejo, José-Manuel Fernández-Real, Robert L. Hanson, Luis Gallart, Joan Vendrell, Anastasia Tsiavou, Erifili Hatziagelaki, Steve E. Humphries, H.-Erich Wichmann, Christian Herder, Thomas Illig
DIABETES - 2006 -
Metabolic effects of
interleukin-6
Ingrid Wernstedt
2005 -
A common polymorphism in the interleukin-6 gene promoter is associated with
overweight
Ingrid Wernstedt, Anna-Lena Eriksson, Anna Berndtsson, J Hoffstedt, Stanko Skrtic, Thomas Hedner, Lillemor Mattsson Hultén, Olov Wiklund, Claes Ohlsson, John-Olov Jansson
Int J Obes Relat Metab Disord - 2004 -
Reduced exercise endurance in interleukin-6-deficient
mice
Jenny Fäldt, Ingrid Wernstedt, Sharyn M. Fitzgerald, Kristina Wallenius, Göran Bergström, John-Olov Jansson
Endocrinology - 2004 -
On the site and mechanism of action of the anti-obesity effects of
interleukin-6.
John-Olov Jansson, Kristina Wallenius, Ingrid Wernstedt, Claes Ohlsson, Suzanne L. Dickson, Ville Wallenius
Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society - 2003