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- Margarita Trobos
Margarita Trobos
Universitetslektor
Avd för biomaterialvetenskapOm Margarita Trobos
Associate Professor Margarita Trobos has a PhD in Medical and Infectious Microbiology from the University of Copenhagen. The PhD was performed at the National Center for Antimicrobials and Infection Control, Statens Serum Institut (Denmark), and supported by a European Marie Curie Fellowship. The PhD thesis dealt with the transmission of antibiotic resistance from animals to humans, detection and typing of resistance bacteria, and gene transfer experiments in humans. Previously, she graduated with a MSc in Biology from Salamanca University (Spain) and worked as a consultant for the World Health Organization (WHO) for the development of data collection tools to measure hospital quality. Since 2010, she has been a researcher at the Department of Biomaterials from University of Gothenburg. She has been the leader of the Infection Control projects and Coordinator of the national VINNOVA funded BIOMATCELL VINN Excellence Center of Biomaterials and Cell Therapy.
Assoc. Prof. Trobos has a research focus on biomaterial-associated infections, covering aspects on the pathogenesis (biofilm mechanisms and antimicrobial resistance) and evaluating novel diagnostic, preventive and therapeutic strategies. She has developed innovative models and techniques to study bacterial-host-biomaterial interactions. In collaboration with clinical partners, she evaluates new tools to improve the diagnosis and treatment of infections associated with orthopaedic implants.
Website: https://www.gu.se/en/research/trobos-group
Research interests:
- Biomaterial-associated infections (pathogenesis, diagnosis, therapy and strategies for infection control)
- Biofilms (mechanisms and quorum sensing)
- Antimicrobial resistance
- Study the relationship between the biomaterials properties, microorganisms and host defense cells
- In vitro and in vivo models of biomaterial-associated infection and analytical techniques for the assessment of novel antimicrobial strategies
-
Biofilm morphology and antibiotic susceptibility of methicillin-resistant Staphylococcus aureus (MRSA) on poly-D,L-lactide-co-poly(ethylene co-poly(ethylene glycol) (PDLLA-PEG) coated
titanium
Adam Benedict Turner, David Zermeno-Perez, Margaritha M. Mysior, Paula Milena Giraldo-Osorno, Begona Garcia, Elizabeth O' Corman, Shafik Oubihi, Jeremy C. Simpson, Inigo Lasa, Tadhg Croinin, Margarita Trobos
BIOFILM - 2024 -
Macrophage-to-osteocyte communication: Impact in a 3D in vitro implant-associated infection
model
Paula Giraldo, Katharina Wirsig, Farah Asa'ad, Omar Omar, Margarita Trobos, Anne Bernhardt, Anders Palmquist
Acta Biomaterialia - 2024 -
Modulation of gene expression and bone formation by expanded and dense polytetrafluoroethylene membranes during guided bone regeneration: An experimental
study
Alberto Turri, O. Omar, Margarita Trobos, Peter Thomsen, Christer Dahlin
Clinical Implant Dentistry and Related Research - 2024 -
Targeting Pseudomonas aeruginosa quorum sensing with sodium salicylate modulates immune responses in vitro and in
vivo.
Erik Gerner, Paula Milena Giraldo-Osorno, Anna Johansson Loo, Rininta Firdaus, Heithem Ben Amara, Maria Werthén, Anders Palmquist, Peter Thomsen, Omar Omar, Sofia Almqvist, Margarita Trobos
Frontiers in cellular and infection microbiology - 2023 -
Effect of minor gallium addition on corrosion, passivity, and antibacterial behaviour of novel β-type Ti–Nb
alloys
Adnan Akman, Ludovico Andrea Alberta, Paula Milena Giraldo-Osorno, Adam Benedict Turner, Martin Hantusch, Anders Palmquist, Margarita Trobos, Mariana Calin, Annett Gebert
Journal of Materials Research and Technology - 2023 -
Accelerated biodegradation of FeMn porous alloy coated with ZnO: Effect on cytocompatibility and antibiofilm
properties
Aleksandra Bartkowska, Adam Benedict Turner, Andreu Blanquer, Aliona Nicolenco, Margarita Trobos, Carme Nogues, Eva Pellicer, Jordi Sort
Surface and Coatings Technology - 2023 -
Biodegradable porous FeMn(-xAg) alloys: assessment of cytocompatibility, mechanical, magnetic and antibiofilm
properties
Aleksandra Bartkowska, Oriol Careta, Adam Benedict Turner, Andreu Blanquer, Elena Ibañez, Margarita Trobos, Carme Nogués, Eva Pellicer, Jordi Sort
Materials Advances - 2023 -
Characterization of staphylococcal clinical isolates obtained from the bone-anchored hearing system and relation to clinical
outcome
Margarita Trobos, Peter Thomsen, Martin L Johansson, Anders Palmquist, Maria Hoffman
Materials Advances - 2023 -
Treatment of periprosthetic joint infections guided by minimum biofilm eradication concentration (MBEC) in addition to minimum inhibitory concentration (MIC): protocol for a prospective randomised clinical
trial.
Jonatan Tillander, Karin Rilby, Karin Svensson Malchau, Susann Skovbjerg, Erika Lindberg, Ola Rolfson, Margarita Trobos
BMJ open - 2022 -
Role of sodium salicylate in Staphylococcus aureus quorum sensing, virulence, biofilm formation and antimicrobial
susceptibility
Adam Benedict Turner, Erik Gerner, Rininta Firdaus, Maite Echeverz, Maria Werthén, Peter Thomsen, Sofia Almqvist, Margarita Trobos
Frontiers in Microbiology - 2022 -
Non-invasive sampling procedure revealing the molecular events at different abutments of bone-anchored hearing systems–A prospective clinical pilot
study
Martin L Johansson, Omar Omar, Margarita Trobos, Sofia Jonhede, Hanna Peters, Malou Hultcrantz, Peter Thomsen
Frontiers in Neuroscience - 2022 -
Genomics of Staphylococcus aureus and Staphylococcus epidermidis from Periprosthetic Joint Infections and Correlation to Clinical
Outcome
Margarita Trobos, Rininta Firdaus, Karin Svensson Malchau, Jonatan Tillander, Dimitrios Arnellos, Ola Rolfson, Peter Thomsen, Iñigo Lasa
Microbiology Spectrum - 2022 -
Sodium salicylate treatment of Pseudomonas aeruginosa stimulates the action of the host immune
response.
Paula Giraldo, Erik Gerner, Maria Werthén, Anders Palmquist, Omar Omar, Sofia Almqvist, Peter Thomsen, Margarita Trobos
8th Thesinge biofilm meeting, May 23-24, 2022, Groningen, The Netherlands - 2022 -
Sodium salicylate decreases Pseudomonas aeruginosa virulence and modulates the host immune
response.
Erik Gerner, Paula Giraldo, Anna Johansson, Rininta Firdaus, Heithem Ben Amara, Maria Werthén, Anders Palmquist, Peter Thomsen, Omar Omar, Sofia Almqvist, Margarita Trobos
ASM conference on Biofilms, Nov. 13-17, 2022 in Charlotte, N.C., USA - 2022 -
Sodium salicylate as a quorum sensing inhibitor in staphylococcus aureus - modulating virulence, biofilm and antimicrobial
susceptibility
Adam Benedict Turner, Erik Gerner, Rininta Firdaus, M Echeverz, Maria Werthén, Peter Thomsen, Sofia Almqvist, Margarita Trobos
ASM conference on Biofilms, Nov. 13-17, 2022 in Charlotte, N.C., USA - 2022 -
Contribution of genetic variations in the regulatory region of surface adhesin-encoding genes to colonization of prosthetic implants by Staphylococcus
aureus.
L Laverde, M Echeverz , Margarita Trobos, Carlos Solano, I Lasa
EuroBioFilms, 31 Ag-3 Sep 2022, Mallorca (Spain) - 2022 -
Sodium salicylate as a quorum sensing inhibitor in S.
aureus
Adam Benedict Turner, Rininta Firdaus, M Echeverz, Maria Werthén, Peter Thomsen, Sofia Almqvist, Margarita Trobos
8th Thesinge biofilm meeting, May 23-24 2022, Groningen, The Netherlands. - 2022 -
Influence of sodium salicylate on Pseudomonas aeruginosa biofilm architecture and susceptibility towards silver
sulphate
Erik Gerner, Maria Werthén, Sofia Almqvist, Margarita Trobos
WUWHS, Abu Dhabi, 1-5 March 2022 - 2022 -
Functional analysis of intergenic regulatory regions of genes encoding surface adhesins in Staphylococcus aureus isolates from periprosthetic
infections
L. Morales-Laverde, Margarita Trobos, M. Echeverz, C. Solano, I. Lasa
Biofilm - 2022 -
Experimental Polymorphism Survey in Intergenic Regions of the icaADBCR Locus in Staphylococcus aureus Isolates from Periprosthetic Joint
Infections
L. Morales-Laverde, M. Echeverz, Margarita Trobos, C. Solano, I. Lasa
Microorganisms - 2022 -
Early plaque formation on PTFE membranes with expanded or dense surface structures applied in the oral cavity of human
volunteers
Alberto Turri, Emina Cirgic, Furqan A. Shah, Maria Hoffman, Omar Omar, Christer Dahlin, Margarita Trobos
Clinical and Experimental Dental Research - 2021 -
Immunomodulatory effects exerted by extracellular vesicles from Staphylococcus epidermidis and Staphylococcus aureus isolated from bone-anchored
prostheses
Magdalena Zaborowska, Forugh Vazirisani, Furqan A. Shah, Rininta Firdaus, Omar Omar, Karin Ekström, Margarita Trobos, Peter Thomsen
Biomaterials - 2021 -
Biofilm properties in relation to treatment outcome in patients with first-time periprosthetic hip or knee joint
infection
Karin Svensson Malchau, Jonatan Tillander, Magdalena Zaborowska, Maria Hoffman, I. Lasa, Peter Thomsen, Henrik Malchau, Ola Rolfson, Margarita Trobos
Journal of Orthopaedic Translation - 2021 -
Antimicrobial Peptide-Functionalized Mesoporous
Hydrogels
S. Atefyekta, E. Blomstrand, A. K. Rajasekharan, Sara Svensson, Margarita Trobos, J. Hong, T. J. Webster, Peter Thomsen, M. Andersson
ACS Biomaterials Science & Engineering - 2021 -
Multimodal Analysis of the Tissue Response to a Bone-Anchored Hearing Implant: Presentation of a Two-Year Case Report of a Patient With Recurrent Pain, Inflammation, and Infection, Including a Systematic Literature
Review.
Martin L Johansson, Tim G A Calon, Omar Omar, Furqan A. Shah, Margarita Trobos, Peter Thomsen, Robert J Stokroos, Anders Palmquist
Frontiers in cellular and infection microbiology - 2021 -
Sodium Salicylate Influences the Pseudomonas aeruginosa Biofilm Structure and Susceptibility Towards
Silver
Erik Gerner, S. Almqvist, Peter Thomsen, Maria Werthén, Margarita Trobos
International Journal of Molecular Sciences - 2021 -
Extracellular Vesicles Influence the Growth and Adhesion of Staphylococcus epidermidis Under Antimicrobial Selective
Pressure
Magdalena Zaborowska, Carles Taulé Flores, Forugh Vazirisani, Furqan A. Shah, Peter Thomsen, Margarita Trobos
Frontiers in Microbiology - 2020 -
Clinical retrieval and analysis of percutaneous bone-anchored hearing implants using multiple analytical
methodologies
Martin L Johansson, Furqan A. Shah, Omar Omar, Margarita Trobos, Tim Calon, Peter Thomsen, Anders Palmquist
11TH WORLD BIOMATERIALS CONGRESS 11 - 15 December 2020 - 2020 -
Clinical retrieval and analysis of percutaneous bone-anchored hearing implants using multiple analytical
methodologies.
Martin L Johansson, Omar Omar, Furqan A. Shah, Margarita Trobos, Tim Calon, Peter Thomsen, Anders Palmquist
11th WORLD BIOMATERIALS CONGRESS, 11 - 15 December 2020 - 2020 -
Sodium salicylate interferes with quorum-sensing-regulated virulence in chronic wound isolates of Pseudomonas aeruginosa in simulated wound
fluid.
Erik Gerner, Sofia Almqvist, Maria Werthén, Margarita Trobos
Journal of medical microbiology - 2020 -
Retrieval, sample processing, and analyses of bone-anchored
implants
Magdalena Zaborowska, Furqan A. Shah, Margarita Trobos, Anders Palmquist
Bone Repair Biomaterials: Regeneration and Clinical Applications, Second Edition - 2019 -
Multimodal analysis of the tissue response to a bone-anchored hearing
implant.
Tim Calon, Martin L Johansson, Omar Omar, Furqan A. Shah, D Budding, Margarita Trobos, Peter Thomsen, R Stokroos, Anders Palmquist
2nd Politzer Society Meeting/2nd World Congress of Otology, 28 May - 1 June, 2019, Warsaw, Poland. - 2019 -
The microbiological profile of the bone-anchored hearing
system.
Martin L Johansson, Margarita Trobos, Omar Omar, Sofia Jonhede, Hanna Peters, Maria Hoffman, Peter Thomsen, Malou Hultcrantz
7th International Symposium on Bone Conduction Hearing and Related Technologies (OSSEO), At Miami beach, FL, USA - 2019 -
Peri-abutment gene expression of the bone-anchored hearing
system.
Martin L Johansson, Omar Omar, Margarita Trobos, Sofia Jonhede, Hanna Peters, Anna Johansson, Malou Hultcrantz, Peter Thomsen
7th International Symposium on Bone Conduction Hearing and Related Technologies (OSSEO), At Miami Beach, FL, USA - 2019 -
Multiscale and Multimodal Analysis of Retrieved Bone-Anchored Hearing
Implants
Martin L Johansson, Omar Omar, Furqan A. Shah, Margarita Trobos, Tim Calon, Malou Hultcrantz, Peter Monksfield, Robert Stokroos, Peter Thomsen, Anders Palmquist
7th International Symposium on Bone Conduction Hearing and Related Technologies (OSSEO), At Miami Beach, FL, USA - 2019 -
Microbiome on the Bone-Anchored Hearing System: A Prospective
Study.
Tim Calon, Margarita Trobos, Martin L Johansson, Joost van Tongeren, Malieka van der Lugt-Degen, Miranda Janssen, Paul Savelkoul, Robert Stokroos, Andries Budding
7th International Symposium on Bone Conduction Hearing and Related Technologies (OSSEO), At Miami Beach, FL, USA - 2019 -
Snapshot assessment of well-established BAHS placed using
MIPS
Martin L Johansson, Omar Omar, Margarita Trobos, Peter Thomsen, Morris David Peter
7th International Symposium on Bone Conduction Hearing and Related Technologies (OSSEO), At Miami Beach, FL, USA - 2019 -
An alternative treatment concept of wound
infections
Erik Gerner, Sofia Almqvist, Maria Werthén, Margarita Trobos
Novel Antimicrobials and AMR Diagnostics, 14-15 March 2019, Berlin, Germany - 2019 -
Plaque formation on exposed expanded PTFE vs dense PTFE membranes. A split- mouth randomized
clinical
study
Alberto Turri, Emina Cirgic, Maria Hoffman, Furqan A. Shah, Omar Omar, Christer Dahlin, Margarita Trobos
Clinical Oral Implants Research - 2019 -
Microbiome on the Bone-Anchored Hearing System: A Prospective
Study
T. G. A. Calon, Margarita Trobos, Martin L Johansson, J. van Tongeren, M. van der Lugt-Degen, A. M. L. Janssen, P. H. M. Savelkoul, R. J. Stokroos, A. E. Budding
Frontiers in Microbiology - 2019 -
The clinical outcome and microbiological profile of bone-anchored hearing systems (BAHS) with different abutment topographies: a prospective pilot
study
Margarita Trobos, Martin L Johansson, S. Jonhede, H. Peters, Maria Hoffman, Omar Omar, Peter Thomsen, M. Hultcrantz
European Archives of Oto-Rhino-Laryngology - 2018 -
In vitro evaluation of barrier function against oral bacteria of dense and expanded polytetrafluoroethylene (PTFE) membranes for guided bone
regeneration
Margarita Trobos, Annika Juhlin, Furqan A. Shah, Maria Hoffman, H. Sahlin, Christer Dahlin
Clinical Implant Dentistry and Related Research - 2018 -
Role of extracellular vesicles from Staphylococcus epidermidis on bacterial growth and biofilm formation under antimicrobial selective pressure
conditions
Magdalena Zaborowska, Carles Taulé-Flores, Forugh Vazirisani, Peter Thomsen, Margarita Trobos
8th ASM Conference on Biofilms, 7-11 October 2018, Washington DC, USA - 2018 -
VIRULENCE FACTOR PRODUCTION AND INHIBITION IN PSEUDOMONAS
AERUGINOSA
Erik Gerner, Sofia Almqvist, Maria Werner, Margarita Trobos
American Society of Microbiology (ASM) - 2018 -
Site-specific gene expression analysis of implant-near cells in a soft tissue infection model - Application of laser microdissection to study biomaterial-associated
infection
Sara Svensson, Margarita Trobos, Omar Omar, Peter Thomsen
Journal of Biomedical Materials Research Part A - 2017 -
The clinical, radiological, microbiological and molecular profile of the skin-penetration site of transfemoral amputees treated with bone-anchored
prostheses.
Maria Lennerås, Georgios Tsikandylakis, Margarita Trobos, Omar Omar, Forugh Vazirisani, Anders Palmquist, Örjan Berlin, Rickard Brånemark, Peter Thomsen
Journal of Biomedical Materials Research - 2017 -
Staphylococcal biofilm gene expression on biomaterials - A methodological
study
Annika Juhlin, Sara Svensson, Peter Thomsen, Margarita Trobos
Journal of Biomedical Materials Research Part A - 2017 -
Biofilm formation and antimicrobial susceptibility of staphylococci and enterococci from osteomyelitis associated with percutaneous orthopaedic
implants.
Magdalena Zaborowska, Jonatan Tillander, Rickard Brånemark, Lars Hagberg, Peter Thomsen, Margarita Trobos
Journal of biomedical materials research. Part B, Applied biomaterials - 2017 -
Effect of load on the bone around bone-anchored amputation
prostheses.
Patrik Stenlund, Margarita Trobos, Jukka Lausmaa, Rickard Brånemark, Peter Thomsen, Anders Palmquist
Journal of orthopaedic research : official publication of the Orthopaedic Research Society - 2017 -
Extracellular vesicles from gram-positive bacteria Staphylococcus aureus and Staphylococcus epidermidis induce a strong inflammatory response and cell death in
vitro
Forugh Vazirisani, Margarita Trobos, Magdalena Zaborowska, Xiaoqin Wang, Omar Omar, Karin Ekström, Peter Thomsen
ISEV 2016, Rotherdam, Netherlands - 2016 -
Commercially pure titanium (cp-Ti) versus titanium alloy (Ti6Al4V) materials as bone anchored implants - Is one truly better than the
other?
Furqan A. Shah, Margarita Trobos, Peter Thomsen, Anders Palmquist
Materials science & engineering. C, Materials for biological applications - 2016 -
Bacteria-material surface interactions: methodological development for the assessment of implant surface induced antibacterial
effects.
Magdalena Zaborowska, Ken Welch, Rickard Brånemark, Poroshat Khalilpour, Håkan Engqvist, Peter Thomsen, Margarita Trobos
Journal of biomedical materials research. Part B, Applied biomaterials - 2015 -
Biomaterial associated infections. How can we address biofilm forming
bacteria.
Margarita Trobos, Magdalena Zaborowska, Rickard Brånemark, Peter Thomsen
6th international conference advances in orthopaedic osseointegration, Las Vegas, NV, 26-28 March. - 2015 -
Bioceramic Implant Induces Bone Healing of Cranial
Defects.
Thomas Engstrand, Lars Kihlström, Kalle Lundgren, Margarita Trobos, Håkan Engqvist, Peter Thomsen
Plastic and reconstructive surgery. Global open - 2015 -
A novel soft tissue model for biomaterial-associated infection and inflammation - bacteriological, morphological and molecular
observations.
Sara Svensson, Margarita Trobos, Maria Hoffman, Birgitta Norlindh, Sarunas Petronis, Jukka Lausmaa, Felicia Suska, Peter Thomsen
Biomaterials - 2015 -
Role of nanostructured gold surfaces on monocyte activation and Staphylococcus epidermidis biofilm
formation.
Sara Svensson, Magnus Forsberg, Mats Hulander, Forugh Vazirisani, Anders Palmquist, Jukka Lausmaa, Peter Thomsen, Margarita Trobos
International journal of nanomedicine - 2014 -
The effect of membrane vesicles from Staphylococcus aureus and Staphylococcus epidermidis on monocytes and
macrophages
Forugh Vazirisani, Margarita Trobos, Xiaoqin Wang, Zivko Mladenović, Anders Palmquist, Omar Omar, Karin Ekström, Peter Thomsen
Second International Meeting of ISEV (International Society for Extracellular Vesicles) 2013, April 17-20, Boston, USA. Abstracts - 2013 -
Osseointegration of titanium with an antimicrobial nanostructured noble metal
coating.
Sara Svensson, Felicia Suska, Lena Emanuelsson, Anders Palmquist, Birgitta Norlindh, Margarita Trobos, Helen Bäckros, Linda Persson, Gunilla Rydja, Mattias Ohrlander, Benny Lyvén, Jukka Lausmaa, Peter Thomsen
Nanomedicine : nanotechnology, biology, and medicine - 2013 -
Staphylococcus epidermidis ability to colonize surfaces is affected by
nanotopography.
M Forsberg, Mats Hulander, Sara Svensson, Jukka Lausmaa, Margarita Trobos, Peter Thomsen
Abstract, Materials for Tomorrow, Chalmers, Gothenburg, Sweden. - 2012 -
Host defence on biomaterial surfaces with intentional, nanometer scale
modifications.
Sara Svensson, Mats Hulander, Jukka Lausmaa, Margarita Trobos, Peter Thomsen
Abstract, Materials for Tomorrow, Chalmers, Gothenburg, Sweden. - 2012 -
A model system to evaluate host defence on biomaterial
surfaces.
Sara Svensson, Mats Hulander, Jukka Lausmaa, Margarita Trobos, Peter Thomsen
Abstract, 9th World Biomaterials Congress, Chengdu, China. - 2012 -
Surface nanotopography affects colonization of
S.epidermidis.
M Forsberg, Mats Hulander, Sara Svensson, Jukka Lausmaa, Margarita Trobos, Peter Thomsen
Abstract, 9th World Biomaterials Congress, Chengdu, China. - 2012 -
Nanostructured noble metals on implants in vitro and in
vivo
Sara Svensson, Felicia Suska, Margarita Trobos, Anna Johansson, Lena Emanuelsson, Anders Palmquist, Birgitta Norlindh, Helen Karlholm, Gunilla Rydja, Mattias Ohrlander, Jukka Lausmaa, Peter Thomsen
Abstract, 4th Annual Meeting, Scandinavian Society for Biomaterials, Fiskebäckskil, Sweden - 2011 -
Characterization of sulphonamide-resistant Escherichia coli using comparison of sul2 gene sequences and multilocus sequence
typing.
Margarita Trobos, Henrik Christensen, Marianne Sunde, Steen Nordentoft, Yvonne Agersø, Gunnar S Simonsen, Anette M Hammerum, John E Olsen
Microbiology (Reading, England) - 2009 -
Natural transfer of sulphonamide and ampicillin resistance between Escherichia coli residing in the human
intestine.
Margarita Trobos, Camilla H Lester, John E Olsen, Niels Frimodt-Møller, Anette M Hammerum
The Journal of antimicrobial chemotherapy - 2009 -
Natural transfer of sulphonamide and ampicillin resistance between Escherichia coli residing in the human
intestine
Margarita Trobos, C. H. Lester, J. E. Olsen, N. Frimodt-Moller, A. M. Hammerum
Journal of Antimicrobial Chemotherapy - 2009 -
Prevalence of sulphonamide resistance and class 1 integron genes in Escherichia coli isolates obtained from broilers, broiler meat, healthy humans and urinary infections in
Denmark.
Margarita Trobos, Lotte Jakobsen, Katharina E P Olsen, Niels Frimodt-Møller, Anette M Hammerum, Karl Pedersen, Yvonne Agersø, Lone J Porsbo, John E Olsen
International journal of antimicrobial agents - 2008