Infection on implants is one of the worst complications and numbers are increasing due to the large elderly population, representing more than half of hospital-acquired infections. These infections are caused by microorganisms that grow in biofilms and are difficult to diagnose and treat. The global rise on antibiotic resistance challenges their control and require urgent innovative alternatives to antibiotics.
1. Virulence inhibitors for the treatment of soft tissue infections
In collaboration with industrial partners, the group is currently addressing alternative treatments for chronic wounds to stop bacterial communication and virulence.
The overall purpose of this research project is to create a deeper understanding of the role of bacterial colonisation and infection in chronic wounds, more specifically the impact of bacterial virulence to the pathogenicity will be studied. The possibility of using virulence inhibitors as a new treatment strategy for hard-to-heal wounds will be pre-clinically evaluated in vitro and in viv
Funding: Swedish Foundation for Strategic Research (SSF; RMA15-0110 2016), Mölnlycke Health Care AB (Sweden), European Union’s Horizon 2020 research and innovation programme under the Marie Sklodowska-Curie grant agreement No 754412 (MoRE2020 - Region Västra Götaland), CARe - Centre for Antibiotic Resistance Research at University of Gothenburg, Handlanden Hjalmar Svensson Foundation, Adlerbertska Foundation and Doctor Felix Neubergh Foundation.
- Gerner E, Almqvist S, Thomsen P, Werthen M, Trobos M. Sodium Salicylate Influences the Pseudomonas aeruginosa Biofilm Structure and Susceptibility Towards Silver. Int J Mol Sci. Jan 21 2021;22(3)DOI:10.3390/ijms22031060.
- Gerner E, Almqvist S, Werthen M, Trobos M. Sodium salicylate interferes with quorum-sensing-regulated virulence in chronic wound isolates of Pseudomonas aeruginosa in simulated wound fluid. J Med Microbiol. Apr 22 2020;DOI:10.1099/jmm.0.001188.