Helena Carén
Om Helena Carén
Helena Caréns forskargrupp: https://www.gu.se/forskning/helena-caren
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The clinical value of proneural, classical and mesenchymal protein signatures in WHO 2021 adult-type diffuse lower-grade
gliomas.
Anna Dénes, Thomas Olsson Bontell, Hanna Barchéus, Sandra Ferreyra Vega, Helena Carén, Cecilia Lindskog, Asgeir Store Jakola, Anja Smits
PloS one - 2023 -
Distinct Cholesterol Localization in Glioblastoma Multiforme Revealed by Mass Spectrometry
Imaging.
Mai H Philipsen, Ellinor Hansson, Auraya Manaprasertsak, Stefan Lange, Eva Jennische, Helena Carén, Kliment Gatzinsky, Asgeir Store Jakola, Emma U Hammarlund, Per Malmberg
ACS chemical neuroscience - 2023 -
Stalled oligodendrocyte differentiation in IDH-mutant
gliomas.
Yanfei Wei, Guanzhang Li, Jing Feng, Fan Wu, Zheng Zhao, Zhaoshi Bao, Wei Zhang, Xiaodong Su, Jiuyi Li, Xueling Qi, Zejun Duan, Yunqiu Zhang, Sandra Ferreyra Vega, Asgeir Store Jakola, Yingyu Sun, Helena Carén, Tao Jiang, Xiaolong Fan
Genome medicine - 2023 -
Small molecule-mediated disruption of ribosome biogenesis synergizes with FGFR inhibitors to suppress glioma cell
growth
A. Zisi, D. C. Kanellis, S. Moussaud, Ida Karlsson, Helena Carén, L. Braeutigam, J. Bartek, M. S. Lindstrom
Neuro-Oncology - 2023 -
Longitudinal DNA methylation analysis of adult-type IDH-mutant
gliomas.
Sandra Ferreyra Vega, Thomas Olsson Bontell, Teresia Kling, Asgeir Store Jakola, Helena Carén
Acta neuropathologica communications - 2023 -
Spatial heterogeneity in DNA methylation and chromosomal alterations in diffuse gliomas and
meningiomas
Sandra Ferreyra Vega, Anna Wenger, Teresia Kling, Thomas Olsson Bontell, Asgeir Store Jakola, Helena Carén
Modern Pathology - 2022 -
Methylation Profiling in Diffuse Gliomas: Diagnostic Value and
Considerations
Anna Wenger, Helena Carén
Cancers - 2022 -
Genome-Wide DNA Methylation Differences in Nonfunctioning Pituitary Adenomas With and Without Postsurgical
Progression
Thomas Hallen, Gudmundur Johannsson, Rahil Dahlén, Camilla A M Glad, C. Orndal, A. Engvall, Helena Carén, Thomas Skoglund, Daniel S Olsson
Journal of Clinical Endocrinology & Metabolism - 2022 -
WHO Grade Loses Its Prognostic Value in Molecularly Defined Diffuse Lower-Grade
Gliomas.
Louise Carstam, Alba Corell, Anja Smits, Anna Dénes, Hanna Barchéus, Klara Modin, Helene Sjögren, Sandra Ferreyra Vega, Thomas Olsson Bontell, Helena Carén, Asgeir Store Jakola
Frontiers in oncology - 2022 -
Stemness and clinical features in relation to the subventricular zone in diffuse lower-grade glioma: an exploratory
study.
Alba Corell, Tomás Gomez Vecchio, Sandra Ferreyra Vega, Anna Dénes, Alice Neimantaite, Alexander Hagerius, Hanna Barcheus, Ole Solheim, Cecilia Lindskog, Thomas Olsson Bontell, Helena Carén, Asgeir Store Jakola, Anja Smits
Neuro-oncology advances - 2022 -
DNA methylation alterations across time and space in paediatric brain
tumours
Anna Wenger, Sandra Ferreyra Vega, Elizabeth Schepke, Maja Löfgren, Thomas Olsson Bontell, M. Tisell, Daniel Nilsson, Teresia Kling, Helena Carén
Acta Neuropathologica Communications - 2022 -
Orthotopic Transplantation of Human Paediatric High-Grade Glioma in Zebrafish
Larvae
Susanna Larsson, Petronella Kettunen, Helena Carén
Brain Sciences - 2022 -
A randomized phase II trial of efficacy and safety of the immunotherapy ALECSAT as an adjunct to radiotherapy and temozolomide for newly diagnosed
glioblastoma.
Katja Werlenius, Giuseppe Stragliotto, Michael Strandeus, Malin Blomstrand, Helena Carén, Asgeir Store Jakola, Bertil Rydenhag, Dorte Dyregaard, Karine N Dzhandzhugazyan, Alexei F Kirkin, Martin K Raida, Anja Smits, Sara Kinhult
Neuro-oncology advances - 2021 -
DNA methylation profiling for molecular classification of adult diffuse lower-grade
gliomas.
Sandra Ferreyra Vega, Thomas Olsson Bontell, Alba Corell, Anja Smits, Asgeir Store Jakola, Helena Carén
Clinical epigenetics - 2021 -
Human Pluripotent Stem Cell-Derived Hepatocytes Show Higher Transcriptional Correlation with Adult Liver Tissue than with Fetal Liver
Tissue.
Nidal Ghosheh, Barbara Küppers-Munther, Annika Asplund, Christian X Andersson, Petter Björquist, Tommy B Andersson, Helena Carén, Stina Simonsson, Peter Sartipy, Jane Synnergren
ACS omega - 2020 -
The clinical significance of the T2-FLAIR mismatch sign in grade II and III gliomas: a population-based
study.
Alba Corell, Sandra Ferreyra Vega, Nickoleta Hoefling, Louise Carstam, Anja Smits, Thomas Olsson Bontell, Isabella Björkman-Burtscher, Helena Carén, Asgeir Store Jakola
BMC cancer - 2020 -
Patterns of care and clinical outcome in assumed glioblastoma without tissue diagnosis: A population-based study of 131 consecutive
patients.
Katja Werlenius, Boglarka Fekete, Malin Blomstrand, Helena Carén, Asgeir Store Jakola, Bertil Rydenhag, Anja Smits
PloS one - 2020 -
Accumulation of DNA methylation alterations in paediatric glioma stem cells following fractionated dose
irradiation
Anna Danielsson, Kristell Barreau, Teresia Kling, Magnus Tisell, Helena Carén
Clinical Epigenetics - 2020 -
Methylation Analysis Using Microarrays: Analysis and
Interpretation.
Teresia Kling, Helena Carén
Methods in molecular biology (Clifton, N.J.), Tumor Profiling - 2019 -
The Gothenburg population-based glioblastoma research database: Methodological aspects and potential
impact
Boglarka Fekete, Katja Werlenius, Helena Carén, Anneli Ozanne, Lars Rosengren, Henrik Zetterberg, Magnus Tisell, Anja Smits, Fredrik Pontén, Cecilia Lindskog, Thomas Olsson Bontell, Asgeir Store Jakola, Bertil Rydenhag
Neurology and Neurosurgery - 2019 -
Intra-Tumor DNA Methylation Heterogeneity in Glioblastoma; Implications for DNA Methylation-Based
Classification.
Anna Wenger, Sandra Ferreyra Vega, Teresia Kling, Thomas Olsson, Asgeir Store Jakola, Helena Carén
Neuro-oncology - 2019 -
The lncRNA TP73-AS1 is linked to aggressiveness in glioblastoma and promotes temozolomide resistance in glioblastoma cancer stem
cells
G. Mazor, L. Levin, D. Picard, U. Ahmadov, Helena Carén, A. Borkhardt, G. Reifenberger, G. Leprivier, M. Remke, B. Rotblat
Cell Death & Disease - 2019 -
Individual Assignment of Adult Diffuse Gliomas into the EM/PM Molecular Subtypes Using a TaqMan Low-Density
Array.
Jiuyi Li, Yang Xue, Anna Wenger, Yingyu Sun, Zheng Wang, Chuan-Bao Zhang, Yunqiu Zhang, Boglarka Fekete, Bertil Rydenhag, Asgeir Store Jakola, Tao Jiang, Helena Carén, Xiaolong Fan
Clinical cancer research : an official journal of the American Association for Cancer Research - 2019 -
Sense-antisense lncRNA pair encoded by locus 6p22.3 determines neuroblastoma susceptibility via the USP36-CHD7-SOX9 regulatory
axis
Tanmoy Mondal, Prasanna Kumar Juvvuna, Agnete Kirkeby, Sanhita Mitra, Subazini Thankaswamy Kosalai, Larissa Traxler, Falk Hertwig, Sara Wernig-Zorc, Caroline Miranda, Lily Deland, Christoph Bartenhagen, Ruth Volland, Deniz Bartsch, Sashidar Bandaru, Anne Engesser, Santhilal Subhash, Tommy Martinsson, Helena Carén, Levent Akyürek, Leo Kurian, Meena Kanduri, Maite Huarte, Per Kogner, Matthias Fischer, Chandrasekhar Kanduri
Cancer Cell - 2018 -
Determinants for Effective ALECSAT Immunotherapy Treatment on Autologous Patient-Derived Glioblastoma Stem
Cells.
Anna Wenger, Katja Werlenius, Alexander Hallner, Fredrik Bergh Thorén, Dan Farahmand, Magnus Tisell, Anja Smits, Bertil Rydenhag, Asgeir Store Jakola, Helena Carén
Neoplasia - 2018 -
Cell line-based xenograft mouse model of paediatric glioma stem cells mirrors the clinical course of the
patient
Susanna Larsson, Anna Wenger, S. Dosa, Magnus Sabel, Teresia Kling, Helena Carén
Carcinogenesis - 2018 -
High expression of MKP1/DUSP1 counteracts glioma stem cell activity and mediates HDAC inhibitor
response
O. Arrizabalaga, L. Moreno-Cugnon, J. Auzmendi-Iriarte, P. Aldaz, II de Caceres,, L. Garros-Regulez, V. Moncho-Amor, S. Torres-Bayona, O. Pernia, L. Pintado-Berninches, P. Carrasco-Ramirez, M. Cortes-Sempere, R. Rosas, P. Sanchez-Gomez, I. Ruiz, Helena Carén, S. Pollard, I. Garcia, A. A. Sacido, R. Lovell-Badge, C. Belda-Iniesta, N. Sampron, R. Perona, A. Matheu
Oncogenesis - 2017 -
Pediatric brain tumor cells release exosomes with a miRNA repertoire that differs from exosomes secreted by normal
cells
Ágota Tüzesi, Teresia Kling, Anna Wenger, Taral R Lunavat, Su Chul Jang, Bertil Rydenhag, Jan Lötvall, S. M. Pollard, Anna Danielsson, Helena Carén
Oncotarget - 2017 -
Validation of the MethylationEPIC BeadChip for fresh-frozen and formalin-fixed paraffin-embedded
tumours.
Teresia Kling, Anna Wenger, Stephan Beck, Helena Carén
Clinical epigenetics - 2017 -
Comparative transcriptomics of hepatic differentiation of human pluripotent stem cells and adult human liver
tissue
Nidal Ghosheh, B. Kuppers-Munther, A. Asplund, J. Edsbagge, B. Ulfenborg, T. B. Andersson, P. Bjorquist, C. X. Andersson, Helena Carén, Stina Simonsson, P. Sartipy, J. Synnergren
Physiological Genomics - 2017 -
Stem cell cultures derived from pediatric brain tumors accurately model the originating
tumors.
Anna Wenger, Susanna Larsson, Anna Danielsson, Kirstine Juul Elbæk, Petronella Kettunen, Magnus Tisell, Magnus Sabel, Birgitta Lannering, Claes Nordborg, Elizabeth Schepke, Helena Carén
Oncotarget - 2017 -
Alterations in Tumor DNA Are Related to Short Postoperative Survival in Patients Resected for Pancreatic Carcinoma Aimed at
Cure.
Annika Gustafsson Asting, David Ljungman, Helena Carén, Zilvinas Dambrauskas, Britt-Marie Iresjö, Anders Hyltander, Peter Naredi, Kent Lundholm
Pancreas - 2016 -
Highly Synchronized Expression of Lineage-Specific Genes during In Vitro Hepatic Differentiation of Human Pluripotent Stem Cell
Lines
Nidal Ghosheh, B. Olsson, J. Edsbagge, B. Kuppers-Munther, M. Van Giezen, A. Asplund, T. B. Andersson, P. Bjorquist, Helena Carén, Stina Simonsson, P. Sartipy, J. Synnergren
Stem Cells International - 2016 -
Stability of patient-derived in vitro cultures of stem-like cells from high-grade paediatric brain
tumours.
Susanna Larsson, Anna Danielsson, Anna Wenger, Magnus Tisell, Magnus Sabel, Birgitta Lannering, Elizabeth Schepke, Helena Carén
Neuro-Oncology - 2016 -
MethPed: an R package for the identification of pediatric brain tumor
subtypes
MT Ahamed, Anna Danielsson, S. Nemes, Helena Carén
Bmc Bioinformatics - 2016 -
Preoperative systemic levels of VEGFA, IL-7, IL-17A, and TNF-beta delineate two distinct groups of children with brain
tumors
E. Sanden, J. E. Perez, E. Visse, M. Kool, Helena Carén, P. Siesjo, A. Darabi
Pediatr Blood Cancer - 2016 -
Differentiation therapy for glioblastoma - too many
obstacles?
Helena Carén, Stephan Beck, Steven M Pollard
Molecular & cellular oncology - 2016 -
Rapid and specific hypomethylation of enhancers in endothelial cells during adaptation to cell
culturing.
Mia Magnusson, Pia Larsson, Emma Xuchun Lu, Niklas Bergh, Helena Carén, Sverker Jern
Epigenetics - 2016 -
Genome-wide methylation profiling identifies novel methylated genes in neuroblastoma
tumors
Maja Olsson, S. Beck, P. Kogner, Tommy Martinsson, Helena Carén
Epigenetics - 2016 -
MethPed: a DNA methylation classifier tool for the identification of pediatric brain tumor
subtypes
Anna Danielsson, Szilard Nemes, Magnus Tisell, Birgitta Lannering, Claes Nordborg, Magnus Sabel, Helena Carén
Clinical Epigenetics - 2015 -
Aberrant immunostaining pattern of the CD24 glycoprotein in clinical samples and experimental models of pediatric
medulloblastomas
E. Sanden, C. Dyberg, Cecilia Krona, E. Visse, Helena Carén, P. A. Northcott, M. Kool, N. Stahl, A. Persson, E. Englund, J. I. Johnsen, P. Siesjo, A. Darabi
Journal of Neuro-Oncology - 2015 -
Glioblastoma stem cells respond to differentiation cues but fail to undergo differentiation commitment and terminal cell cycle
arrest
Helena Carén, SH Stricker, H Bulstrode, S Gagrica, E Johnstone, TE Bartlett, A Feber, G Wilson, A Teschendorff, P Bertone, S Beck, SM Pollard
STEM CELL REPORTS - 2015 -
Dynamic Enhancer Methylation - A Previously Unrecognized Switch for Tissue-Type Plasminogen Activator
Expression.
Mia Magnusson, Emma Xuchun Lu, Pia Larsson, Erik Ulfhammer, Niklas Bergh, Helena Carén, Sverker Jern
PloS one - 2015 -
The dynamics of DNA methylation covariation patterns in
carcinogenesis
Teschendorff A, X Liu, Helena Carén, SM Pollard, S Beck, M Widschwendter, L Chen
PLoS Computational Biology - 2014 -
EFFECTS OF IN VITRO CULTURING OF PEDIATRIC BRAIN TUMOR STEM
CELLS.
Magnus Tisell, Anna Danielsson, Helena Carén
Neuro-Oncology - 2014 -
CHARACTERIZING THE RADIORESPONSE OF PEDIATRIC BRAIN TUMOR STEM CELLS CULTURED IN
VITRO
Anna Danielsson, Magnus Tisell, Bertil Rydenhag, Helena Carén
Neuro-Oncology - 2014 -
Widespread resetting of DNA methylation in glioblastoma-initiating cells suppresses malignant cellular behavior in a lineage-dependent
manner.
Stefan H Stricker, Andrew Feber, Pär G Engström, Helena Carén, Kathreena M Kurian, Yasuhiro Takashima, Colin Watts, Michael Way, Peter Dirks, Paul Bertone, Austin Smith, Stephan Beck, Steven M Pollard
Genes & development - 2013 -
Integrated virus-host methylome analysis in head and neck squamous cell
carcinoma.
Gareth A Wilson, Matthias Lechner, Anna Köferle, Helena Carén, Lee M Butcher, Andrew Feber, Tim Fenton, Amrita Jay, Chris Boshoff, Stephan Beck
Epigenetics - 2013 -
The good, the bad and the ugly: epigenetic mechanisms in
glioblastoma.
Helena Carén, Steven M Pollard, Stephan Beck
Molecular aspects of medicine - 2013 -
Genomic Profiling of Neuroblastoma Tumors – Prognostic Impact of Genomic
Aberrations
Helena Carén
Neuroblastoma. Diagnosis, Therapy, and Prognosis - 2012 -
The RASSF gene family members RASSF5, RASSF6 and RASSF7 show frequent DNA methylation in
neuroblastoma.
Anna Djos, Tommy Martinsson, Per Kogner, Helena Carén
Molecular cancer - 2012 -
COX-2 Gene Expression in Colon Cancer Tissue related to Regulating Factors and Promoter Methylation
Status
Annika Gustafsson Asting, Helena Carén, Marianne Andersson, Christina Lönnroth, Kristina Lagerstedt, Kent Lundholm
BMC Cancer - 2011 -
Identification of epigenetically regulated genes that predict patient outcome in
neuroblastoma
Helena Carén, Anna Djos, Maria Nethander, Rose-Marie Sjöberg, Per Kogner, Camilla Enström, Staffan Nilsson, Tommy Martinsson
BMC Cancer - 2011 -
Comprehensive SNP array study of frequently used neuroblastoma cell lines; copy neutral loss of heterozygosity is common in the cell lines but uncommon in primary
tumors.
Hanna Kryh, Helena Carén, Jennie Erichsen, Rose-Marie Sjöberg, Jonas Abrahamsson, Per Kogner, Tommy Martinsson
BMC genomics - 2011 -
Appearance of the novel activating F1174S ALK mutation in neuroblastoma correlates with aggressive tumor progression and unresponsiveness to
therapy.
Tommy Martinsson, Therese Eriksson, Jonas Abrahamsson, Helena Carén, Magnus Hansson, Per Kogner, Sattu Kamaraj, Christina Schönherr, Joel Weinmar, Kristina Ruuth, Ruth H Palmer, Bengt Hallberg
Cancer research - 2011 -
High-risk neuroblastoma tumors with 11q-deletion display a poor prognostic, chromosome instability phenotype with later
onset.
Helena Carén, Hanna Kryh, Maria Nethander, Rose-Marie Sjöberg, Catarina Träger, Staffan Nilsson, Jonas Abrahamsson, Per Kogner, Tommy Martinsson
PNAS - 2010 -
Verification of genes differentially expressed in neuroblastoma tumours: a study of potential tumour suppressor
genes.
Kaisa Thorell, Annika Bergman, Helena Carén, Staffan Nilsson, Per Kogner, Tommy Martinsson, Frida Abel
BMC medical genomics - 2009 -
Germline mutation screening of the Saethre-Chotzen-associated genes TWIST1 and FGFR3 in families with BRCA1/2-negative breast
cancer.
Annika Bergman, Pelle Sahlin, Monica Emanuelsson, Helena Carén, Peter Tarnow, Tommy Martinsson, Henrik Grönberg, Göran Stenman
Scandinavian journal of plastic and reconstructive surgery and hand surgery / Nordisk plastikkirurgisk forening [and] Nordisk klubb for handkirurgi - 2009 -
The Neuroblastoma Genome and Epigenome - Patient Stratification and Identification of Candidate
Genes
Helena Carén
2009 -
High incidence of DNA mutations and gene amplifications of the ALK gene in advanced sporadic neuroblastoma
tumours.
Helena Carén, Frida Abel, Per Kogner, Tommy Martinsson
The Biochemical journal - 2008 -
High incidence of DNA mutations and gene amplifications of the ALK gene in advanced sporadic neuroblastoma
tumours
Helena Carén, Frida Abel, Per Kogner, Tommy Martinsson
Biochemical Journal - 2008 -
Analysis of neuroblastoma tumour progression; loss of PHOX2B on 4p13 and 17q gain are early events in neuroblastoma
tumorigenesis
Cecilia Krona, Helena Carén, Rose-Marie Sjöberg, Bengt Sandstedt, Genevieve Laureys, Per Kogner, Tommy Martinsson
International Journal of Oncology - 2008 -
High-resolution array copy number analyses for detection of deletion, gain, amplification and copy-neutral LOH in primary neuroblastoma tumors; Four cases of homozygous deletions of the CDKN2A
gene.
Helena Carén, Jennie Erichsen, Linda Olsson, Charlotta Enerbäck, Rose-Marie Sjöberg, Jonas Abrahamsson, Per Kogner, Tommy Martinsson
BMC Genomics - 2008 -
Genetic and epigenetic changes in the common 1p36 deletion in neuroblastoma
tumours.
Helena Carén, Susanne Fransson, Katarina Ejeskär, Per Kogner, Tommy Martinsson
British Journal of Cancer - 2007 -
The two human homologues of yeast UFD2 ubiquitination factor, UBE4A and UBE4B, are located in common neuroblastoma deletion regions and are subject to mutations in
tumours.
Helena Carén, Annika Holmstrand, Rose-Marie Sjöberg, Tommy Martinsson
European journal of cancer (Oxford, England : 1990) - 2006 -
Introduction of in vitro transcribed ENO1 mRNA into neuroblastoma cells induces cell
death.
Katarina Ejeskär, Cecilia Krona, Helena Carén, Faten Zaibak, Lingli Li, Tommy Martinsson, Panayiotis A Ioannou
BMC cancer - 2005 -
A cluster of genes located in 1p36 are down-regulated in neuroblastomas with poor prognosis, but not due to CpG island
methylation.
Helena Carén, Katarina Ejeskär, Susanne Fransson, Luke Hesson, Farida Latif, Rose-Marie Sjöberg, Cecilia Krona, Tommy Martinsson
Molecular cancer - 2005 -
A novel 1p36.2 located gene, APITD1, with tumour-suppressive properties and a putative p53-binding domain, shows low expression in neuroblastoma
tumours.
Cecilia Krona, Katarina Ejeskär, Helena Carén, Frida Abel, Rose-Marie Sjöberg, Tommy Martinsson
British journal of cancer - 2004 -
DNA microarray analysis of chromosomal susceptibility regions to identify candidate genes for allergic disease: a pilot
study.
Mikael Benson, Per-Arne Svensson, Mikael Adner, Helena Carén, Björn Carlsson, Lena M S Carlsson, Tommy Martinsson, Mats Rudemo, Lars Olaf Cardell
Acta Oto-Laryngologica - 2004 -
Introduction of in vitro transcribed ENO1 mRNA into neuroblastoma cells induces massive cell
death.
Katarina Ejeskär, Cecilia Krona, Rose-Marie Sjöberg, Helena Carén, Tommy Martinsson, Panayiotis A Ioannou
Advances in Neuroblastoma Research 2004, Genoa, Italy - 2004