Levent Akyürek
Professor/specialistläkare
Avdelningen förOm Levent Akyürek
Levent Akyürek is a vascular biologist in the field of angiogenesis during cardiovascular remodeling and tumor growth. Akyürek's early work defined the cellular interactions that stimulate the vasculoproliferative responses during transplant vasculopathy. These studies have indicated the important cellular determinants of neointima formation. Later, he examined neointimal smooth muscle and endothelial cell biology, both by inhibiting cellular proliferation using adenoviral gene therapy and by studying genes linked to cell cycle control.
His research activity has recently become focused on the involvement of filamins, a group of cytoskeleton proteins, in vascular cell signaling and transcription during the progression of cardiovascular and tumor diseases. Generation of filamin-deficient mouse models as well as mouse models to study the biological role of filamins during the progression of tumor growth and cardiovascular remodeling have been produced for the first time in his laboratory.
Dr. Akyürek graduated from the Medical School, Dokuz Eylül University, Turkey in 1989, and then completed his PhD program at Uppsala University in 1996. He worked as a postdoctoral fellow in the laboratory of Elizabeth G. Nabel at the University of Michigan and the National Institutes of Health, USA between 1997 and 2002. Dr. Akyürek became an Associate Professor of Cell Biology in 2004 and Professor in Pathology in 2014 at the University of Gothenburg. He currently acts as a reviewer on the editorial boards of several scientific journals in the field of vascular biology, transplantation immunology and molecular biology. He is also serving as clinical consultant pathologist and cytologist with expertise in pulmonary/thorax and molecular pathology at the Sahlgrenska Academy Hospital in Gothenburg.
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Antioxidants promote intestinal tumor progression in
mice.
Zhiyuan V. Zou, Kristell Le Gal, Ahmed E El Zowalaty, Lara Pehlivanoglu, Viktor Garellick, Nadia Gul, Mohamed X Ibrahim, Per-Olof Bergh, Marcus Henricsson, Clotilde Wiel, Levent Akyürek, Martin Bergö, Volkan I. Sayin, Per Lindahl
Antioxidants - 2021-01-01 -
Pulmonary manifestations of systemic
karyomegaly.
Levent Akyürek, Aziz Hussein, Andrew G Nicholson, Nils-Johan Mauritz, Johan Mölne
Respiratory Medicine Case Reports - 2020-01-01 -
Can a peritoneal conduit become an
artery?
Petter Davik, Zuzana Chabadova, Martin Altreuther, Ingeborg Leinan, Sashidar Bandaru, Levent Akyürek, Erney Mattsson
EJVES Vascular Forum - 2020-01-01 -
The Impact of Age and Luminal Preservation on the Development of Intestinal Preservation Injury in
Rats
John M. Söfteland, Anna Casselbrant, Levent Akyürek, Mats Hellström, Mihai Oltean
Transplantation - 2020-01-01 -
Lack of RAC1 in macrophages protects against
atherosclerosis.
Sashidar Bandaru, Chandu Ala, Matias Ekstrand, Murali K Akula, Matteo Pedrelli, Xi Liu, Göran Bergström, Liliana Håversen, Jan Borén, Martin O. Bergö, Levent Akyürek
PLoS One - 2020-01-01 -
IGL-1 as a preservation solution in intestinal transplantation: a multicenter
experience.
Emilio Canovai, Mihai Oltean, Gustaf Herlenius, Levent Akyürek, Guido Trentadue, Gerard Dijkstra, Jan W Haveman, Andreas Pascher, Gert De Hertogh, Diethard Monbaliu, Jacques Pirenne, Laurens J Ceulemans
Transplant International - 2020-01-01 -
Response by Akyürek et al to Letter Regarding Article, "Targeting Filamin A Reduces Macrophage Activity and
Atherosclerosis".
Levent Akyürek, Martin O. Bergö, Sashidar Bandaru
Circulation - 2019-01-01 -
Targeting filamin A reduces macrophage activity and
atherosclerosis.
Sashidar Bandaru, Chandu Ala, Reza Salimi, Murali K Akula, Matias Ekstrand, Sravani Devarakonda, Joakim Karlsson, Jimmy Van den Eynden, Göran Bergström, Max Levin, Jan Borén, Martin O. Bergö, Levent Akyürek
Circulation - 2019-01-01 -
Sense-antisense lncRNA pair encoded by locus 6p22.3 determines neuroblastoma susceptibility via the USP36-CHD7-SOX9 regulatory
axis
Tanmoy Mondal, Prasanna Kumar Juvvuna, Agnete Kirkeby, Sanhita Mitra, Subazini Thankaswamy Kosalai, Larissa Traxler, Falk Hertwig, Sara Wernig-Zorc, Caroline Miranda, Lily Deland, Christoph Bartenhagen, Ruth Volland, Deniz Bartsch, Sashidar Bandaru, Anne Engesser, Santhilal Subhash, Tommy Martinsson, Helena Carén, Levent Akyürek, Leo Kurian, Meena Kanduri, Maite Huarte, Per Kogner, Matthias Fischer, Chandrasekhar Kanduri
Cancer Cell - 2018-01-01 -
Blocking the cleavage of filamin A by calpain inhibitor decreases tumor cell
growth
Reza Salimi, Sashidar Bandaru, Sravani Devarakonda, Sevtap Gökalp, Chandu Ala, Ali Alvandian, Nilgün Yener, Levent Akyürek
Anticancer Research - 2018-01-01 -
A review on traumatic diaphragmatic
rupture
Joel Lundgren, SH Mousavie, AR Negahi, B Nakhaei, G Varga, Hans Granhed, Levent Akyürek, M Hosseini, David Pazooki
Trauma and Emergency Care - 2017-01-01 -
Tidig forskningssatsning ger långsiktigt
engagemang.
Puja Shahrouki, Åsa Torinsson Naluai, Agneta Ekman, Eric Hanse, Olle Larkö, Levent Akyürek
Läkartidningen - 2017-01-01 -
Depletion of ATP and glucose in advanced human atherosclerotic
plaques
Matias Ekstrand, Emma Widell, Anna Hammar, Levent Akyürek, Martin Johansson, Björn Fagerberg, Göran Bergström, Malin Levin, Per Fogelstrand, Jan Borén, Max Levin
PLoS One - 2017-01-01 -
Management of gunshot wounds in a scandinavian
hospital
Joel Lundgren, SH Mousavie, AR Negahi, Levent Akyürek, Hans Granhed, M Hosseini, David Pazooki
Trauma and Emergency Care - 2017-01-01 -
Spontaneous twin pregnancy with live births after cryopreservation and re-implantation of ovarian
tissue
Milan Milenkovic, Mats Brännström, Cesar Diaz-Garcia, Kersti Lundin, Ulrika Selleskog, Brita Söderlund, Ali Khatibi, Berit Gull, Hans Bokström, Constantina Mateoiu, Levent Akyürek, Ann Thurin-Kjellberg
Gynecological Surgery - 2017-01-01 -
Traumatic diaphragmatic ruptures: A 10-year retrospective
study
Joel Lundgren, SH Mousavie, AR Negahi, B Nakhaei, G Varga, Levent Akyürek, Hans Granhed, M Hosseini, David Pazooki
Trauma and Emergency Care - 2017-01-01 -
Emergency thoracotomy in a Swedish setting: A consecutive series of 45 patients from a Scandinavian trauma
hospital
Joel Beck, Hans Granhed, Levent Akyürek, David Pazooki
Journal of Trauma and Treatment - 2016-01-01 -
Antioxidants can increase melanoma metastasis in
mice.
Kristell Le Gal, Mohamed X Ibrahim, Clotilde Wiel, Volkan I. Sayin, Murali K Akula, Christin Karlsson, Martin Dalin, Levent Akyürek, Per Lindahl, Jonas A Nilsson, Martin Bergö
Science Translational Medicine - 2015-01-01 -
Deficiency of filamin A in endothelial cells impairs left ventricular remodeling after myocardial
infarction.
Sashidar Bandaru, Julia Grönros, Björn Redfors, Cağlar Cil, David Pazooki, Reza Salimi, Erik Larsson, Alex-Xianghua Zhou, Elmir Omerovic, Levent Akyürek
Cardiovascular Research - 2015-01-01 -
p110alpha hot spot mutations E545K and H1047R exert metabolic reprogramming independently of p110alpha kinase
activity
Aditi Chaudhari, Daniel Krumlinde, Annika Lundqvist, Levent Akyürek, Sashidar Bandaru, Kristina Skålen, Marcus Ståhlman, Jan Borén, Yvonne Wettergren, Katarina Ejeskär, Victoria Rotter Sopasakis
Molecular and Cellular Biology - 2015-01-01 -
The risk-associated long noncoding RNA NBAT-1 controls neuroblastoma progression by regulating cell proliferation and neuronal
differentiation.
Gaurav Kumar Pandey, Sanhita Mitra, Santhilal Subhash, Falk Hertwig, Meena Kanduri, Kankadeb Mishra, Susanne Fransson, Abiarchana Ganeshram, Tanmoy Mondal, Sashidar Bandaru, Malin Östensson, Levent Akyürek, Jonas Abrahamsson, Susan Pfeifer, Erik Larsson, Leming Shi, Zhiyu Peng, Matthias Fischer, Tommy Martinsson, Fredrik Hedborg, Per Kogner, Chandrasekhar Kanduri
Cancer Cell - 2014-01-01 -
Amanuensprogram lockar forskarintresserade i
Göteborg.
Levent Akyürek, Fredrik Hessulf, Ka-Wei Tang, Eric Hanse, Catharina Lindholm
Läkartidningen - 2014-01-01 -
Targeting filamin B induces tumor growth and metastasis via enhanced activity of matrix metalloproteinase-9 and secretion of
VEGF-A
Sashidar Bandaru, Xianghua Zhou, Pegah Rouhi, Yan Zhang, Martin Bergö, Cao Yihai, Levent Akyürek
Oncogenesis - 2014-01-01 -
Hypoxia-induced and calpain-dependent cleavage of filamin-A regulates the hypoxic
response.
Xiaowei Zheng, Alex-Xianghua Zhou, Pegah Rouhi, Hidetaka Uramoto, Jan Borén, Yihai Cao, Teresa Pereira, Levent Akyürek, Lorenz Poellinger
Proceedings of the National Academy of Science of the United States of America - 2014-01-01 -
Dose-dependent cardioprotection of enkephalin analogue Eribis peptide 94 and cardiac expression of opioid receptors in a porcine model of ischaemia and
reperfusion
Lars O Karlsson, Niklas Bergh, Lizhen Li, E. Bissessar, I. Bobrova, G. J. Gross, Levent Akyürek, Lars Grip
European journal of pharmacology - 2012-01-01 -
Targeting filamin A reduces K-RAS-induced lung adenocarcinomas and endothelial response to tumor growth in
mice
Rajesh K. Nallapalli, Mohamed X Ibrahim, Xianghua Zhou, Sashidar Bandaru, Sai Naresh Sunkara, Björn Redfors, David Pazooki, Yin Zhang, Jan Borén, Yihai Cao, Martin Bergö, Levent Akyürek
Molecular Cancer - 2012-01-01 -
Filamin A mediates HGF/c-MET signaling in tumor cell
migration.
Xianghua Zhou, Asli Toylu, Rajesh K. Nallapalli, Gisela M A Nilsson, Nese Atabey, Carl-Henrik Heldin, Jan Borén, Martin Bergö, Levent Akyürek
International journal of cancer. Journal international du cancer - 2011-01-01 -
Filamins in cell signaling, transcription and organ
development.
Xianghua Zhou, John H Hartwig, Levent Akyürek
Trends in Cell Biology - 2010-01-01 -
Deficiency of cyclin-dependent kinase inhibitors p21(Cip1) and p27(Kip1) accelerates atherogenesis in apolipoprotein E-deficient
mice.
Levent Akyürek, Manfred Boehm, Michelle Olive, Xianghua Zhou, Hong San, Elizabeth G Nabel
Biochemical and Biophysical Research Communications - 2010-01-01 -
Cyclosporine does not reduce myocardial infarct size in a porcine ischemia-reperfusion
model.
Lars O Karlsson, Xianghua Zhou, Erik Larsson, Karin Åström-Olsson, Chrichan Månsson, Levent Akyürek, Lars Grip
Journal of Cardiovascular Pharmacology and Therapeutics - 2010-01-01 -
Endothelial cells are activated during hypoxia via endoglin/ALK-1/SMAD1/5 signaling in vivo and in
vitro.
Fei Tian, Xianghua Zhou, Anke M Smits, Erik Larsson, Marie-José Goumans, Carl-Henrik Heldin, Jan Borén, Levent Akyürek
Biochemical and Biophysical Research Communications - 2010-01-01 -
A positive relationship between filamin and VEGF in patients with lung
cancer
Hidetaka Uramoto, Levent Akyürek, T Hanagiri
Anticancer Research - 2010-01-01 -
Differences in lesion severity and cellular composition between in vivo assessed upstream and downstream sides of human symptomatic carotid atherosclerotic
plaques
Björn Fagerberg, Mikael Ryndel, Josefin Kjelldahl, Levent Akyürek, Lars Rosengren, Lars Karlström, Göran Bergström, Fredrik J. Olson
Journal of Vascular Surgery - 2010-01-01 -
Protein disulfide isomerase increases in myocardial endothelial cells in mice exposed to chronic hypoxia: a stimulatory role in
angiogenesis.
Fei Tian, Xianghua Zhou, Johannes Wikström, Helen Karlsson, Helen Sjöland, Li-Ming Gan, Jan Borén, Levent Akyürek
American Journal of Physiology. Heart and Circulatory Physiology - 2009-01-01 -
Up- and downstream structural differences in carotid plaque composition - implications for studies of human symptomatic carotid
plaques
Fredrik J. Olson, Levent Akyürek, Erney Mattsson, Olov Wiklund, Björn Fagerberg
Atherosclerosis Supplements - 2008-01-01 -
15-Lipoxygenase-2 expression in human macrophages induces chemokine secretion and T cell
migration.
Kristina Danielsson Norén, Ellen Rydberg Knutsen, Madeleine Ingelsten, Levent Akyürek, Pernilla Jirholt, Christina Ullström, Gun-Britt Forsberg, Jan Borén, Olov Wiklund, Lillemor Mattsson Hultén
Atherosclerosis - 2008-01-01 -
Developmental origin of smooth muscle cells in the descending aorta in
mice.
Per Wasteson, Bengt R Johansson, Tomi Jukkola, Silke Breuer, Levent Akyürek, Juha Partanen, Per Lindahl
Development (Cambridge, England) - 2008-01-01 -
RhoA-dependent vascular smooth muscle cell-specific transcription: adding diaphanous formins to the
puzzle.
Erik Larsson, Xianghua Zhou, Levent Akyürek
Arteriosclerosis, Thrombosis, and Vascular Biology - 2007-01-01 -
Filamins in cardiovascular
development.
Xianghua Zhou, Jan Borén, Levent Akyürek
Trends in Cardiovascular Medicine - 2007-01-01 -
Filamin B deficiency in mice results in skeletal malformations and impaired microvascular
development
Xianghua Zhou, Fei Tian, Johan Sandzen, R. Cao, E. Flaberg, L. Szekely, Y. Cao, Claes Ohlsson, Martin Bergö, Jan Borén, Levent Akyürek
Proc Natl Acad Sci U S A - 2007-01-01 -
Diverse origin of vascular smooth muscle cells in the
neointima
Xianghua Zhou, Caroline Beck, Jan Borén, Levent Akyürek
Anadolu Kardiyol Derg - 2005-01-01 -
Tissue-specific targeting for cardiovascular gene transfer. Potential vectors and future
challenges
Caroline Beck, Hidetaka Uramoto, Jan Borén, Levent Akyürek
Current Gene Therapies - 2004-01-01 -
Enhanced mucosal immunoglobulin A response of intranasal adenoviral vector human immunodeficiency virus vaccine and localization in the central nervous
system.
Franck Lemiale, Wing-pui Kong, Levent Akyürek, Xu Ling, Yue Huang, Bimal K Chakrabarti, Michael Eckhaus, Gary J Nabel
Journal of Virology - 2003-01-01 -
Gene transfer strategies to inhibit neointima
formation.
Martin F Crook, Levent Akyürek
Trends in Cardiovascular Medicine - 2003-01-01