Swedish Covid-19 Investigation for Future Insights – a Population Epidemiology Approach using Register Linkage (SCIFI-PEARL)

Ailiana Santosa, Forskare

Brian Kirui, Doktorand

Chioma Nwaru, Postdoctor

Fredrik Nyberg, Projektledare och Professor i Registerepidemiologi

Huiqi Li, Statistiker / Forskare

Maria Bygdell, Postdoctor 

Yiyi Xu, Forskare

Ailiana Santosa, Forskare

Björn Wettermark, Professor i läkemedelsepidemiologi vid Institutionen för farmaci / Uppsala Universitet

Fredrik Nyberg, Projektledare och Professor i Registerepidemiologi

Mohammadhossein Hajiebrahimi, Forskningsassistent vid Institutionen för farmaci / Uppsala Universitet

Ailiana Santosa, Forskare

Brian Kirui, Doktorand

Chioma Nwaru, Postdoktor

Fredrik Nyberg, Projektledare och Professor i Registerepidemiologi

Huiqi Li, Statistiker / Forskare

Johan Sundström, Professor vid Institutionen för medicinska vetenskaper/ Uppsala Universitet

Lowie Vanfleteren, Universitetslektor/specialistläkare

Magnus Gisslen, Professor/överläkare

Magnus Lindh, Professor/överläkare

• Nyberg F, Franzén S, Lindh M, Vanfleteren L, Hammar N, Wettermark B, Sundström J, Santosa A, Björck S, Gisslén M. Swedish Covid-19 Investigation for Future Insights – A Population Epidemiology Approach Using Register Linkage (SCIFI-PEARL). Clin Epidemiol. 2021;13:649-659. https://doi.org/10.2147/CLEP.S312742

• Shakibfar S, Nyberg F, Li H, Zhao J, Nordeng HME, Sandve GKF, Pavlovic M, Hajiebrahimi M, Andersen M, Sessa M. Artificial intelligence-driven prediction of COVID-19-related hospitalization and death: a systematic review. Front Public Health. 2023 Jun 20;11:1183725. doi: 10.3389/fpubh.2023.1183725. PMID: 37408750; PMCID: PMC10319067.

• Kirui BK, Santosa A, Vanfleteren LEGW, Li H, Franzén S, Stridsman C, Nyberg F. Pre- and post-vaccination characteristics and risk factors for COVID-19 outcomes in a Swedish population-based cohort of COPD patients. ERJ Open Res. 2023 Jun 26;9(3):00711-2022. doi: 10.1183/23120541.00711-2022. PMID: 37377661; PMCID: PMC10291311.

• Labor M, Kirui B, Nyberg F, Vanfleteren L. Regular inhaled corticosteroids use may protect against severe COVID-19 outcome in COPD. Int J COPD. 2023. In press.

• Bygdell M, Kindblom JM, Martikainen J, Li H, Nyberg F. Incidence and Characteristics in Children with post-COVID-19 condition in Sweden. In press.

• Kirui B, Santosa A, Franzén S, Vanfleteren L, Stridsman C, Nyberg F. Pre- and post-vaccination characteristics and risk factors for COVID-19 outcomes in a Swedish population-based cohort of COPD patients. ERJ Open research. In press. 

• Ljung R, Xu Y, Sundström A, Leach S, Hallberg E, Bygdell M, Larsson M, Arthurson V, Gisslén M, Gedeborg R, Nyberg F. Association between SARS-CoV-2 vaccination and healthcare contacts for menstrual disturbance and bleeding in women before and after menopause: nationwide, register based cohort study. BMJ. 2023 May 3;381:e074778. doi: 10.1136/bmj-2023-074778. PMID: 37137493.

• Dahlén T, Flygt H, Lübking A, Olsson-Strömberg U, Wennström L, Dreimane A, Själander A, Leach S, Gisslén M, Li H, Höglund M, Stenke L, Nyberg F. The impact of Covid-19 in patients with chronic myeloid leukemia-a nationwide population-based study. Leukemia. 2023 May;37(5):1156-1159. doi: 10.1038/s41375-023-01893-1. Epub 2023 Apr 10. PMID: 37037908; PMCID: PMC10088575.
• Shedrawy J, Ernst P, Lönnroth K, Nyberg F. The burden of disease due to COVID-19 in Sweden 2020-2021: A disability-adjusted life years (DALYs) study. Scand J Public Health. 2023 Mar 20:14034948231160616. doi: 10.1177/14034948231160616. Epub ahead of print. PMID: 36941820.
• Nwaru C, Li H, Bonander C, Santosa A, Franzén S, Rosvall M, Nyberg F. Occupational role and COVID-19 among foreign-born healthcare workers in Sweden: a registry-based study. Eur J Public Health. 2023 Apr 1;33(2):202-208. doi: 10.1093/eurpub/ckad016. PMID: 36762873; PMCID: PMC10066486.
• Spetz M, Lundberg L, Nwaru C, Li H, Santosa A, Ng N, Leach S, Gisslén M, Hammar N, Nyberg F, Rosvall M. An intersectional analysis of sociodemographic disparities in Covid-19 vaccination: A nationwide register-based study in Sweden. Vaccine. 2022 Nov 2;40(46):6640-6648. doi: 10.1016/j.vaccine.2022.09.065. Epub 2022 Sep 28. PMID: 36210254; PMCID: PMC9515344.
• Bygdell M, Leach S, Lundberg L, Gyll D, Martikainen J, Santosa A, Li H, Gisslén M, Nyberg F. A comprehensive characterization of patients diagnosed with post-COVID-19 condition in Sweden 16 months after the introduction of the International Classification of Diseases Tenth Revision diagnosis code (U09.9): a population-based cohort study. Int J Infect Dis. 2023 Jan;126:104-113. doi: 10.1016/j.ijid.2022.11.021. Epub 2022 Nov 21. PMID: 36410693; PMCID: PMC9678230.
• Dahlén T, Li H, Nyberg F, Edgren G. A population-based, retrospective cohort study of the association between ABO blood group and risk of COVID-19. J Intern Med. 2023 Mar;293(3):398-402. doi: 10.1111/joim.13588. Epub 2022 Nov 26. PMID: 36372955; PMCID: PMC9877780.
• Xu Y, Li H, Kirui B, Santosa A, Gisslén M, Leach S, Wettermark B, Vanfleteren LEGW, Nyberg F. Effectiveness of COVID-19 Vaccines over 13 Months Covering the Period of the Emergence of the Omicron Variant in the Swedish Population. Vaccines. 2022; 10(12):2074. https://doi.org/10.3390/vaccines10122074.
• Mousa SI, Nyberg F, Hajiebrahimi M, Bertilsson R, Nåtman J, Santosa A, Wettermark B. Initiation of antihypertensive drugs to patients with confirmed COVID-19-A population-based cohort study in Sweden. Basic Clin Pharmacol Toxicol. 2022 Sep;131(3):196-204. doi: 10.1111/bcpt.13766. Epub 2022 Jul 6. PMID: 35726121; PMCID: PMC9349802.
• Spetz M, Lundberg L, Nwaru C, Li H, Santosa A, Leach S, Gisslén M, Hammar N, Rosvall M, Nyberg F. The social patterning of Covid-19 vaccine uptake in older adults: A register-based cross-sectional study in Sweden. Lancet Reg Health Eur. 2022 Apr;15:100331. doi: 10.1016/j.lanepe.2022.100331. Epub 2022 Feb 26. PMID: 35252941; PMCID: PMC8881226.
• Sundh J, Ekström M, Palm A, Ljunggren M, Emilsson ÖI, Grote L, Cajander S, Li H, Nyberg F. COVID-19 and Risk of Oxygen-Dependent Chronic Respiratory Failure: A National Cohort Study. Am J Respir Crit Care Med. 2022 Aug 15;206(4):506-509. doi: 10.1164/rccm.202202-0323LE. Erratum in: Am J Respir Crit Care Med. 2022 Nov 15;206(10):1300. PMID: 35549847.
• Santosa A, Franzén S, Nåtman J, Wettermark B, Parmryd I, Nyberg F. Protective effects of statins on COVID-19 risk, severity and fatal outcome: a nationwide Swedish cohort study. Sci Rep. 2022 Jul 14;12(1):12047. doi: 10.1038/s41598-022-16357-2. PMID: 35835835; PMCID: PMC9282150.
• Nyberg F, Lindh M, Vanfleteren L, Hammar N, Wettermark B, Sundström J, Santosa A, Kirui BK, Gisslén M. Adverse events of special interest for COVID-19 vaccines - background incidences vary by sex, age and time period and are affected by the pandemic. Preprint. medRxiv 2021.10.04.21263507; doi: https://doi.org/10.1101/2021.10.04.21263507
• Nwaru CA, Santosa A, Franzén S, Nyberg F. Occupation and COVID-19 diagnosis, hospitalisation and ICU admission among foreign-born and Swedish-born employees: a register-based study. J Epidemiol Community Health. 2022 Jan 7;76(5):440–7. doi: 10.1136/jech-2021-218278. Epub ahead of print. PMID: 34996808; PMCID: PMC8761595.

• Shakibfar S, Zhao J, Li H, Nordeng H, Lupatelli A, Pavlovic M, Sandve GK , Nyberg F, Pavlovic M, Wettermark B, Hajiebrahimi M, Andersen M, Sessa M. Machine learning-driven development of a disease risk score for COVID-19 hospitalization and mortality: A Swedish and Norwegian register-based study. Submitted.

• Lundberg L, Leach S, Xu Y, Martikainen J, Santosa A, Gisslén M, Li H, Nyberg F, Bygdell M. Covid-19 vaccine effectiveness against Post Covid-19 Condition – A register-based cohort study among 589,722 individuals in Sweden. Submitted.

• Søfteland JM, Li H, Magnusson J, Leach S, Friman V, Gisslén M, Felldin M, Schult A, Karason K, Baid-Agrawal S, Wallquist C, Nyberg F. COVID-19 outcomes and vaccinations in Swedish solid organ transplant recipients 2020-2021: A nationwide multi-register comparative cohort study. Submitted.

• Morten Andersen, Mia Aakjær, Saeed Shakibfar, Hedvig Nordeng, Elisabeth Pedersen, Nhung Trinh, Angela Lupattelli, Jing Zhao, Eimir Hurley, Fredrik Nyberg, Huiqi Li, Bjorn Wettermark, Mohammadhossein Hajiebrahimi, Marion Clark Bennie, Amanj Kurdi, Daniel Morales, David Moreno-Martos and Maurizio Sessa. Nordic COllaborative HEalth REgister Network for Covid-19 Epidemiology (Nordic COHERENCE). Submitted.
• Sundh J, Palm A, Ljunggren A, Emilsson ÖI, Grote L, Cajander S, Li H, Nyberg F, Ekström M. Risk and outcomes of COVID-19 in patients with oxygen-dependent chronic respiratory failure– a national cohort study. Submitted.
• Bergthorsdottir R, Esposito D, Olsson DS, Ragnarsson O, Dahlqvist P, Bensing S, Nåtman J, Johannsson G, Nyberg F. Increased risk of hospitalisation, intensive care, and death due to COVID-19 in patients with adrenal insufficiency: a Swedish nationwide study. Submitted.

Abstracts och muntliga presentationer inom SCIFI-PEARL-projektet:

2023

• Bergthorsdottir R, Esposito D, Johannsson G, Ragnarsson O, Dahlqvist P, Bensing S, Nåtman J, Nyberg F. Hospitalisation, Intensive Care and Death due to COVID-19 in Swedish Patients with Adrenal Insufficiency. Abstract at the ENDO 2023 Conference. 15. – 18. June 2023. Chicago, USA.

2022

• Nwaru C, Li H, Bonander C, Santosa A, Franzén S, Rosvall M, Nyberg F. Occupational variation in the risk of Covid-19 infection and hospitalization among foreign-born healthcare workers in Sweden: a registry-based study. Oral at the State of the Art Covid-19 Conference 2022. 16. – 17. November 2022. Online.
• Ernst P, Shedrawy J, Lönnroth K, Nyberg F. The burden of disease due to COVID-19 in Sweden: a disability-adjusted life years (DALY) study. Poster at the State of the Art Covid-19 Conference 2022. 16. – 17. November 2022. Online. [Winner Best Poster Award]
• Spetz M, Lundberg L, Nwaru C, Li H, Santosa A, Ng N, Leach S, Gisslén M, Hammar N, Nyberg F, Rosvall M. An intersectional analysis of sociodemographic disparities in Covid-19 vaccination: A nationwide register-based study in Sweden. Poster at the State of the Art Covid-19 Conference 2022. 16. – 17. November 2022. Online. [Runner up Best Poster Award]
• Xu Y, Li H, Kirui B, Santosa A, Gisslén M, Leach S, Wettermark B, Vanfleteren L, Nyberg F. Effectiveness of Covid-19 vaccines over 13 months covering the period of the emergence of the Omicron variant in the Swedish population. Poster at the State of the Art Covid-19 Conference 2022. 16. – 17. November 2022. Online.
• Sundh J, Ekström M, Palm A, Ljunggren M, Emilsson Ö, Grote L, Cajander S, Li H, Nyberg F. Covid-19 and risk of oxygen-dependent chronic respiratory failure – a national cohort study within the SCIFI-PEALR project. Poster at the State of the Art Covid-19 Conference 2022. 16. – 17. November 2022. Online.
• Bygdell M, Leach S, Lundberg L, Gyll D, Martikainen J, Santosa A, Li H, Gisslén M, Nyberg F. A comprehensive characterization of patients diagnosed with post-covid-19 condition: a population-based study from SCIFI-PEARL. Poster at the State of the Art Covid-19 Conference 2022. 16. – 17. November 2022. Online.
• Nyberg F, Dahlén T, Li H, Edgren G. A population-based, retrospective cohort study of the association between ABO blood group and risk of Covid-19. Poster at the State of the Art Covid-19 Conference 2022. 16. – 17. November 2022. Online.
• Shedrawy J, Ernst P, Lönnroth K, Nyberg F. The burden of disease due to COVID-19 in Sweden: a disability-adjusted life years (DALY) study. Poster at the 15th European Public Health Conference 2022. 09. – 12. November 2022. Berlin. [Presented by Ernst P]
• Nwaru C, Li H, Bonander C, Santosa A, Franzén S, Rosvall M, Nyberg F. Occupational role and Covid-19 among foreign-born healthcare workers: a registry-based study. Poster at the 15th European Public Health Conference 2022. 09. – 12. November 2022. Berlin. 
• Labor M, Nyberg F, Kirui B, Vanfleteren L. Impact of treatment with inhaled corticosteroids on COVID-19 risk and outcome – a potential protective effect on severity of disease survival.  Abstract presentation at the European Respiratory Society (ERS) International Congress. 04. – 06. September 2022. Barcelona. [Presented by Labor M]
• Mousa SI, Nyberg F, Hajiebrahimi M, Bertilsson R, Nåtman J, Santosa A, Wettermark B. Initiation of antihypertensive drugs to patients with confirmed COVID-19-A population-based cohort study in Sweden. Poster at the 38th International Conference on Pharmacoepidemiology & Therapeutic Risk Management (ICPE). 24. – 28. August 2022. Copenhagen. [Presented by Hajiebrahimi M]
• Shiahn H, Wettermark B, Nyberg F, Hajiebrahimi M. Drug utilization and characteristics of COVID-19 positive pre-and postmenopausal women diagnosed with breast cancer – A cross-sectional SCIIF-PEARL study. Poster at the 38th International Conference on Pharmacoepidemiology & Therapeutic Risk Management (ICPE). 24. – 28. August 2022. Copenhagen. [Presented by Hajiebrahimi M]
• Spetz M, Lundberg L, Nwaru C, Li H, Santosa A, Leach S, Gisslén M, Hammar N, Rosvall M, Nyberg F. The social patterning of Covid-19 vaccine uptake in older adults: a register-based cross-sectional study in Sweden. Poster at the 38th International Conference on Pharmacoepidemiology & Therapeutic Risk Management (ICPE). 24. – 28. August 2022. Copenhagen. [Presented by Nyberg F] 
• Kirui B, Labor M, Nyberg F, Vanfleteren L. Inhaled corticosteroids and COVID-19 risk and outcomes – Findings from a population-based cohort within the SCIFI-PEARL project.  Abstract presentation at the 38th International Conference on Pharmacoepidemiology & Therapeutic Risk Management (ICPE). 24. – 28. August 2022. Copenhagen.
• Kirui B, Santosa A, Vanfleteren L, Stridsman C, Nyberg F. Characteristics of asthma patients with COVID-19 by disease severity and across age groups – a Swedish population-based analysis within the SCIFI-PEARL project. Poster at the 38th International Conference on Pharmacoepidemiology & Therapeutic Risk Management (ICPE). 24. – 28. August 2022. Copenhagen.
• Xu Y, Li H, Kirui B, Santosa B, Gisslén B, Leach S, Wettermark B, Vanfleteren L, Nyberg F. Long-lasting Vaccine effect before Omicron and progressively waning after Omicron -  a Swedish study  over 13 Months. Abstract presentation at the Nordic Conference of Epidemiology and Register-Based Health Research (NordicEPI). 18. – 19. August 2022. Reykjavik. [Presented by Li H]
• Bygdell M, Leach S, Lundberg L, Gyll D, Martikainen J, Santosa A, Li H, Gisslén M, Nyberg F. A comprehensive characterization of the patient population diagnosed with post-COVID-19 condition in Sweden one year after the introduction of the ICD-10 diagnosis code U09.9 - a study within the SCIFI-PEARL project. Abstract presentation at the Nordic Conference of Epidemiology and Register-Based Health Research (NordicEPI). 18. – 19. August 2022. Reykjavik. [Presented by Nyberg F]
• Sundh J, Ekström M, Palm A, Ljunggren M, Emilsson Ö, Grote L, Cajander S, Li H, Nyberg F. COVID-19 and risk of oxygen-dependent chronic respiratory failure – a national cohort study. Abstract presentation at the Nordic Conference of Epidemiology and Register-Based Health Research (NordicEPI). 18. – 19. August 2022. Reykjavik. [Presented by Nyberg F]
• Kirui B, Santosa A, Vanfleteren L, Franzén S, Stridsman C, Nyberg F. Characteristics and risk factors for COVID-19 outcomes in a Swedish population-based cohort of COPD patients from the SCIFI-PEARL project. Abstract presentation at the Nordic Conference of Epidemiology and Register-Based Health Research (NordicEPI). 18. – 19. August 2022. Reykjavik.
• Santosa A, Oras J, Li H, Nwaru C, Kirui B, Nyberg F. Clinical characteristics and outcomes of critically ill patients with COVID-19 in Sweden – a population-based cohort study. Abstract presentation at the Nordic Conference of Epidemiology and Register-Based Health Research (NordicEPI). 18. – 19. August 2022. Reykjavik.
• Sundh J, Ekström M, Palm A, Ljunggren M, Emilsson Ö, Grote L, Cajander S, Li H, Nyberg F. COVID-19 and risk of oxygen-dependent chronic respiratory failure – a national cohort study. Poster at the Svenska Lungkongressen. 27. – 29. April 2022. Malmö

2021

• Nyberg F, Franzén S, Lindh M, Vanfleteren L, Hammar N, Wettermark B, Sundström J, Santosa A, Björk S, Gisslen M. SCIFI-PEARL – en bred nationell studie av covid-19 med en kontinuerlig uppdaterad databas. [SCIFI-PEARL: Swedish Covid-19 Investigation for Future Insights – a Population Epidemiology Approach using Register Linkage]. Poster at the State of the Art Covid-19 Conference. Digital, 2020.
• Nyberg F, Franzén S, Santosa A, Vanfleteren L, Hammar N, Sundström J, Lindh M, Björk S, Gisslén M, Wettermark B. SCIFI-PEARL: Swedish Covid-19 Investigation for Future Insights – a Population Epidemiology Approach using Register Linkage. Poster at the 37th International Conference on Pharmacoepidemiology and Therapeutic Risk Management (ICPE 37) of the International Society of Pharmacoepidemiology (ISPE). Digital, 2021.
• Nyberg F, Santosa A, Parmryd I, Wettermark B, Franzén S. Impact of Statin Treatment on COVID-19 Risk and Outcome – a Potential Positive Effect on Survival. Poster at the 37th International Conference on Pharmacoepidemiology and Therapeutic Risk Management (ICPE 37) of the International Society of Pharmacoepidemiology (ISPE). Digital, 2021.
• Santosa A, Franzén S, Wettermark B, Parmryd I, Nyberg F. Protective effects of statin treatment on COVID-19 risk, severity and fatal outcome – a nationwide Swedish cohort study. Abstract presentation at the Nordic Pharmacoepidemiological Networks 13^th annual meeting (NorPEN). Digital, 2021.
• Kirui B, Santosa A, Franzén S, Vanfleteren L, Stridsman C, Nyberg F. Characteristics and outcomes of COVID-19 patients with preexisting COPD in Sweden: A population-based register study. Abstract presentation at the Nordic Pharmacoepidemiological Networks 13^th annual meeting (NorPEN). Digital, 2021.
• Nyberg F, Lindh M, Vanfleteren L, Hammar N, Wettermark B, Sundström J, Santosa A, Kirui B, Gisslén M. Potentiella biverkningar för Covid-19-vacciner – bakgrundsincidenser varierar med ålder och kön, över tid och påverkas av pandemin – en befolkningsbaserad registerstudie inom SCIFI-PEARL-projektet. [Potential side effects of COVID-19 vaccines - background incidences vary with age and gender, over time and are affected by the pandemic - a population-based registry study within the SCIFI-PEARL project]. Poster at the State of the Art Covid-19 Conference. Digital, 2021.
• Kirui B, Santosa A, Franzén S, Vanfleteren L, Stridsman C, Nyberg F. Karakterisering av COVID-19-patienter med astma i Sverige - en befolkningsbaserad registerstudie inom SCIFI-PEARL-projektet. [Characterization of COVID-19 patients with asthma in Sweden - a population-based register study within the SCIFI-PEARL project]. Poster at the State of the Art Covid-19 Conference. Digital, 2021.
• Kirui B, Santosa A, Franzén S, Vanfleteren L, Stridsman C, Nyberg N. Riskfaktorer och covid-19-utfall bland patienter med kronisk obstruktiv lungsjukdom i Sverige – en populations-baserad registerstudie inom SCIFI-PEARL Projekt. [Risk factors and covid-19 outcome in patients with chronic obstructive pulmonary lung disease in Sweden - a population-based registry study within the SCIFI PEARL Project]. Poster at the State of the Art Covid-19 Conference. Digital, 2021.
• Labor M, Nyberg F, Kirui B, Vanfleteren L. Inhalerade kortikosteroider (IKS) och covid-19 – potentiell skyddande effekt på svårighetsgrad och överlevnad – preliminära resultat av SCIFI-PEARL-projektet. [Inhaled corticosteroids and covid-19 - potential protective effect on severity and survival - preliminary results from the SCIFI-PEARL project]. Abstract at the State of the Art Covid-19 Conference. Digital, 2021.
• Nwaru C, Santosa A, Franzén S, Nyberg F. Yrke och Covid-19-utfall bland utrikesfödda och svenskfödda i Sverige- en registerbaserad studie inom SCIFI-PEARL projektet. [Occupation and Covid-19 outcome among foreign-born and Swedish-born in Sweden - a register-based study within the SCIFI-PEARL project]. Poster at the State of the Art Covid-19 Conference. Digital, 2021.

• Trysell, K. (2021, November 25). Svenska forskare: Statiner tycks skydda mot död i covid-19. https://lakartidningen.se/aktuellt/nyheter/2021/11/svenska-forskare-statiner-tycks-skydda-mot-dod-i-covid-19/
• Ljung R, Nyberg F. Vaccination var inte kopplad till fler läkarbesök för mensrubbningar. Läkartidningen. 2023; 20-21. Läkartidningen.se 2023-05-04.