Grupp Clotilde Wiel

Sammanfattning av forskning

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Forskningsverktyg och resurser

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Nuvarande gruppmedlemmar

Clotilde Wiel, PhD, Forskargruppledare (Junior PI)
Dorota Raj, PhD, Postdoc
Kevin Ali, MSc, Doktorand
Moa Beischer, Forskar-AT

Utvalda publikationer

1. Ageing promotes metastasis via activation of the integrated stress response.
   Patel AAH, Dzanan JJ, Ali KX, Eklund EA, Alvarez SW, Raj D, Dankis M, Altinönder I, Schwarz M, Le Gal K, Bedel E, El Zowalaty AE, Jonasson E, Albatrok H, Gul N, Bossowski JP, Pillai R, Micke P, Botling J, Akyürek LM, Angeletti D, Sayin SI, Härtlova A, Papagiannakopoulos T, Olofsson Bagge R, Ståhlberg A, Hallqvist A, Wiel C, Sayin VI*. Nature. 2026 Apr;652(8112):1339-1348. *Co-corresponding author.
    
2. Development of a high-throughput screening platform for identification of functional BACH1 inhibitors reveals compounds with anti-invasive potential.
   Ali KX, Klenja-Skudrinja D, Higgins M, Walker D, Sharaf Y, Dankis M, Patel AAH, Raj D, Dzanan JJ, Svenningsen EB, Langlands A, Poulsen T, Honda T, Dinkova-Kostova AT, Wiel C*, Sayin VI, de la Vega L*. Redox Biol. 2026 Jul;94:104187. *Co-corresponding author.
    
3. Amino acid restriction sensitizes lung cancer cells to ferroptosis via GCN2-dependent activation of the integrated stress response.
   Garellick VA, Gul N, Horrieh P, Mustafa D, Patel AAH, Dankis M, Alvarez SW, Berndtson J, Mahdavi S, Schwarz M, Persson A, Zahirovic F, Wiel C, Sayin VI, Lindahl P. Redox Biol. 2026 Mar;90:103988.
    
4. NRF2 activation by myeloid cell-derived oxidative stress induces SNAI-driven features of EMT in breast cancer.
   Kaya M, Johnsson O, Issdisai N, Paul S, Wiel C, Dongre A, Hellstrand K, Martner A. Proc Natl Acad Sci U S A. 2026 May 26;123(21):e2521491123.
    
5. Monotherapy With Immune Checkpoint Blockade Improves Survival Outcomes in KRAS-Mutant but Not KRAS Wild-Type Metastatic Lung Adenocarcinoma: Validation From an Extended Swedish Cohort.
   Eklund EA, Sayin SI, Jonsson JS, van Renswoude H, Nyman J, Hallqvist A, Wiel C*, Sayin VI*. JTO Clin Res Rep. 2025 Jul 17;6(10):100880. *Co-corresponding author.
    
6. Distinct metastatic organotropism shapes prognosis in lung adenocarcinoma with brain metastasis.
   Sayin SI, Eklund EA, Ali KX, Dzanan JJ, Xylander M, Dankis M, Lindahl P, Sayin VI, Hallqvist A, Wiel C. Front Oncol. 2025 Apr 4;15:1569517.
    
7. Targeting RAS-converting enzyme 1 overcomes senescence and improves progeria-like phenotypes of ZMPSTE24 deficiency.
   Yao H, Chen X, Kashif M, Wang T, Ibrahim MX, Tüksammel E, Revêchon G, Eriksson M, Wiel C*, Bergo MO*. Aging Cell. 2020 Aug;19(8):e13200. *Co-corresponding author.
    
8. The JAK1/2 inhibitor ruxolitinib delays premature aging phenotypes.
   Griveau A*, Wiel C*, Ziegler DV, Bergo MO, Bernard D (2020) ​​​​​Aging Cell. 19: e13122. *co-first author.
    
9. BACH1 Stabilization by Antioxidants Stimulates Lung Cancer Metastasis.
   Wiel C, Le Gal K, Ibrahim MX, Jahangir CA, Kashif M, Yao H, Ziegler DV, Xu X, Ghosh T, Mondal T, Kanduri C, Lindahl P, Sayin VI, Bergo MO. Cell. 2019 Jul 11;178(2):330-345.e22.

Fler publikationer från grupp Clotilde Wiel på PubMed