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- Erik Smedler
Erik Smedler
Universitetslektor, adjungerad
Sektionen för psykiatri och neurokemiOm Erik Smedler
Dr. Smedler är ST-läkare i psykiatri vid Sahlgrenska universitetssjukhuset (SU) och forskargruppledare vid Göteborgs universitet (GU). Han är ledamot i Sveriges unga akademi sedan 2024. Dessförinnan tog han sin läkarexamen och doktorsexamen (MD-PhD) vid Karolinska Institutet samt en civilingenjörsexamen i teknisk fysik vid Kungliga Tekniska högskolan i Stockholm. Hans avhandling fokuserade på neurala nätverk och kalciumsignalering.
Därefter flyttade han till Göteborg för en postdoktoral tjänst i Mikael Landéns forskargrupp vid GU (2017–2019) och för att genomföra sin allmäntjänstgöring vid SU. År 2020 påbörjade han sin specialistutbildning i psykiatri vid SU och startade samtidigt sin egen oberoende forskargrupp med en ALF-tjänst. I februari 2022 utnämndes han till docent i psykiatri. Samma år beviljades han även två större startanslag från Vetenskapsrådet och Wallenbergcentrum för molekylär och translationell medicin.
Dr Smedler är medlem i ECNP iPSCs Platform for Neuropsychiatry Network, Psychiatric Genomics Consortium Functional Genomics subgroup och grundare av the Swedish human IPS network (ShiPS) och regionala forskningsnätverket BRAINWEST.
Publikationer
Forskargrupp
Läs mer på smedlerlab.org
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Mapping the transcriptional diversity of calcium signaling in the mouse and human
brain
Ibrahim Al Rayyes, Lauri Louhivuori, Ivar Dehnisch Ellström, Erik Smedler, Per Uhlén
Iscience - 2026 -
Old enough to be a model? On the role of maturity in stem cell-based models for neuropsychiatric
disorders
Bingqing He, Erik Smedler
Neuroscience Applied - 2026 -
Psilocin mediates long-term synaptic depression in the prelimbic cortex through 5-HT2A receptor-independent
mechanisms
Ana Domi, Erika Lucente, Davide Cadeddu, Niklas Bengtsson, Erik Smedler, Louise Adermark
Neuropharmacology - 2026 -
Polymorphisms and Bipolar
Disorder
Parvaneh Nikpour, Erik Smedler
Handbook of the Biology and Pathology of Mental Disorders - 2025 -
Clonidine prevents radiation-induced cell death in human brain
organoids
Martin Lundberg, Marja Koskuvi, Asimenia Gkogka, Mahnaz Nikpour, Melis Çelik, Erik Smedler, Bo Stenerlow, Per-Arne Lonnqvist, Martin Schalling, Carl M. Sellgren
SCIENTIFIC REPORTS - 2025 -
Efficient Gene-Editing in Human Pluripotent Stem Cells Through Simplified Assembly of Adeno-Associated Viral (AAV) Donor
Templates.
Berta Marco de La Cruz, Sanhita Mitra, Bingqing He, Melis Çelik, Debora Kaminski, Erik Smedler, Fredrik H Sterky
Bio-protocol - 2024 -
Key subphenotypes of bipolar disorder are differentially associated with polygenic liabilities for bipolar disorder, schizophrenia, and major depressive
disorder
Jie Song, Lina Jonsson, Yi Lu, Sarah E. Bergen, Robert Karlsson, Erik Smedler, Katherine Gordon-Smith, Ian Jones, Lisa Jones, Nick Craddock, Patrick F. Sullivan, Paul Lichtenstein, Arianna Di Florio, Mikael Landén
MOLECULAR PSYCHIATRY - 2024 -
Effect of CYP2C19 polymorphisms on antidepressant prescription patterns and treatment emergent mania in bipolar
disorder.
Erik Joas, Lina Jonsson, Alexander Viktorin, Erik Smedler, Erik Pålsson, Guy M Goodwin, Mikael Landén
The pharmacogenomics journal - 2023 -
Association of premorbid intelligence with level of functioning and illness severity in bipolar
disorder.
Erik Smedler, Timea Sparding, Lina Jonsson, Elin Hörbeck, Mikael Landén
Journal of affective disorders - 2023 -
Metabolomics analysis of cerebrospinal fluid suggests citric acid cycle aberrations in bipolar
disorder
Erik Smedler, Alireza Salehi, Aurimantas Pelanis, Ana Andreazza, Erik Pålsson, Timea Sparding, Mikael Landén
Neuroscience Applied - 2022 -
Cerebrospinal fluid proteomic study of two bipolar disorder
cohorts
Anniella Isgren, Andreas Göteson, Jessica Holmén Larsson, Aurimantas Pelanis, C. Sellgren, Erik Joas, Timea Sparding, Henrik Zetterberg, Erik Smedler, Joel Jakobsson, Mikael Landén
Molecular Psychiatry - 2022 -
Disrupted Cacna1c gene expression perturbs spontaneous Ca2+ activity causing abnormal brain development and increased
anxiety.
Erik Smedler, Lauri Louhivuori, Roman A Romanov, Débora Masini, Ivar Dehnisch Ellström, Chungliang Wang, Martino Caramia, Zoe West, Songbai Zhang, Paola Rebellato, Seth Malmersjö, Irene Brusini, Shigeaki Kanatani, Gilberto Fisone, Tibor Harkany, Per Uhlén
Proceedings of the National Academy of Sciences of the United States of America - 2022 -
Cerebrospinal fluid and serum protein markers in autism: A co-twin
study.
Erik Smedler, Johanna Kleppe, Janina Neufeld, Karl Lundin, Sven Bölte, Mikael Landén
Journal of neurochemistry - 2021 -
Cerebrospinal fluid proteomics targeted for central nervous system processes in bipolar
disorder
Andreas Göteson, Anniella Isgren, Lina Jonsson, Timea Sparding, Erik Smedler, Aurimantas Pelanis, Henrik Zetterberg, Joel Jakobsson, Erik Pålsson, Jessica Holmén Larsson, Mikael Landén
Molecular Psychiatry - 2021 -
Association of CACNA1C polymorphisms with serum BDNF levels in bipolar
disorder.
Erik Smedler, Erik Pålsson, Kenji Hashimoto, Mikael Landén
The British journal of psychiatry : the journal of mental science - 2021 -
Reporting trigger factors for (hypo)manic episodes in bipolar disorder: association with personality and
prognosis.
Erik Smedler, Timea Sparding, Ali Hattab, Carl M Sellgren, Mikael Landén
Acta psychiatrica Scandinavica - 2020 -
CACNA1C polymorphism and brain cortical structure in bipolar
disorder
Erik Smedler, Christoph Abé, Erik Pålsson, Martin Ingvar, Mikael Landén
Journal of psychiatry & neuroscience : JPN - 2019 -
Genes, biomarkers, and clinical features associated with the course of bipolar
disorder.
Erik Smedler, Sarah E Bergen, Jie Song, Mikael Landén
European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology - 2019 -
Mapping genes for calcium signaling and their associated human genetic
disorders.
Matthias Hörtenhuber, Enrique M Toledo, Erik Smedler, Ernest Arenas, Seth Malmersjö, Lauri Louhivuori, Per Uhlén
Bioinformatics (Oxford, England) - 2017 -
The 1p36 Tumor Suppressor KIF 1B beta Is Required for Calcineurin Activation, Controlling Mitochondrial Fission and
Apoptosis
S. J. Li, S. M. Fell, O. Surova, Erik Smedler, K. Wallis, Z. X. Chen, U. Hellman, J. I. Johnsen, Tommy Martinsson, R. S. Kenchappa, P. Uhlen, P. Kogner, S. Schlisio
Developmental Cell - 2016 -
CO2-evoked release of PGE2 modulates sighs and inspiration as demonstrated in brainstem organotypic
culture.
David Forsberg, Zachi Horn, Evangelia Tserga, Erik Smedler, Gilad Silberberg, Yuri Shvarev, Kai Kaila, Per Uhlén, Eric Herlenius
eLife - 2016 -
Calcium signaling in neocortical
development.
Per Uhlén, Nicolas Fritz, Erik Smedler, Seth Malmersjö, Shigeaki Kanatani
Developmental neurobiology - 2015 -
Network analysis of time-lapse microscopy
recordings.
Erik Smedler, Seth Malmersjö, Per Uhlén
Frontiers in neural circuits - 2014 -
Cathelicidin LL-37 induces time-resolved release of LTB4 and TXA2 by human macrophages and triggers eicosanoid generation in
vivo.
Min Wan, Oliver Soehnlein, Xiao Tang, Anne M van der Does, Erik Smedler, Per Uhlén, Lennart Lindbom, Birgitta Agerberth, Jesper Z Haeggström
FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 2014 -
Frequency decoding of calcium
oscillations.
Erik Smedler, Per Uhlén
Biochimica et biophysica acta - 2014 -
Small-world networks of spontaneous Ca(2+)
activity.
Seth Malmersjö, Paola Rebellato, Erik Smedler, Per Uhlén
Communicative & integrative biology - 2013 -
Neural progenitors organize in small-world networks to promote cell
proliferation.
Seth Malmersjö, Paola Rebellato, Erik Smedler, Henrike Planert, Shigeaki Kanatani, Isabel Liste, Evanthia Nanou, Hampus Sunner, Shaimaa Abdelhady, Songbai Zhang, Michael Andäng, Abdeljabbar El Manira, Gilad Silberberg, Ernest Arenas, Per Uhlén
Proceedings of the National Academy of Sciences of the United States of America - 2013 -
Small molecule screening platform for assessment of cardiovascular toxicity on adult zebrafish
heart.
Satish Srinivas Kitambi, Erik Smedler, Petra Sekyrova, Cristian Ibarra, Gilbert Nyah Tekeoh, Michael Andäng, Patrik Ernfors, Per Uhlén
BMC physiology - 2012