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Hans Carlsten
Seniorforskare
Department of Rheumatology and Inflammation ResearchAbout Hans Carlsten
Hans Carlsten (born 1954) has in several earlier studies established that estrogen exerts a dichotomous effect on the immune system.
His group was the first to demonstrate that estrogen- and testosterone-mediated suppression of T-cell-dependent inflammation is inherited as dominant traits. Using ER knock-out mice, they mapped the roles of ERα and ERβ in estrogen-mediated effects on the development and regulation of the immune system and on immune responsiveness. In murine models of autoimmune rheumatic diseases they revealed that physiological doses of estrogen accelerate SLE and ameliorate RA.
Main topic is to explore the cellular and molecular mechanisms by which estrogen downregulates arthritis and preserves bone loss during systemic inflammation. In clinical studies of postmenopausal RA patients, Dr. Carlsten and coworkers have established that HRT has beneficial effects not only on bone mineral density but also on disease activity and erosivity in joints. Since long-term use of HRT has been associated with increased risk of breast cancer, thrombosis, and possibly also stroke, they have focused on the possible use of selective estrogen receptor modulators for treatment of arthritis.
Recently, they demonstrated that the selective estrogen receptor modifier raloxifene reduces joint destruction and bone loss triggered by arthritis and inflammation. In a review article (“Immune responses and bone loss: the estrogen connection” Immunological Reviews 2005) Dr Carlsten has summerized his scientific achievements.
For his translational scientific work he was awarded the Nanna Svartz price in 2009.
Group members
- Cecilia Engdahl – Associate professor, Reseacher
- Jauquline Nordqvist - PhD student
- Annica Andersson – PhD student
- Merja Nurkkala – PhD, Research engineer
- Anna-Karin Hultgård-Ekwall – PhD, Researcher
- Beatrice Bergström – MD
-
Local Immune Activation and Age Impact on Humoral Immunity in Mice, with a Focus on IgG
Sialylation.
Priti Gupta, Tibor Sághy, Miriam Bollmann, Tao Jin, Claes Ohlsson, Hans Carlsten, Carmen Corciulo, Cecilia Engdahl
Vaccines - 2024 -
Role of estrogen signaling in fibroblastic reticular cells for innate and adaptive immune responses in antigen-induced
arthritis
Aidan Barrett, Karin Horkeby, Carmen Corciulo, Hans Carlsten, Marie K Lagerquist, Julia Scheffler, Ulrika Islander
IMMUNOLOGY AND CELL BIOLOGY - 2024 -
Treatment with a tissue-selective oestrogen complex does not affect disease pathology but reduces pre-BI cells in lupus-prone
mice.
Christina Drevinge, Julia Scheffler, Jauqueline Nordqvist, Cecilia Engdahl, Hans Carlsten, Ulrika Islander
Scandinavian journal of rheumatology - 2024 -
Impact of estrogen on IgG glycosylation and serum protein glycosylation in a murine model of healthy
postmenopause.
Priti Gupta, Tibor Sághy, Jauqueline Nordqvist, Jonas Nilsson, Hans Carlsten, Karin Horkeby, Petra Henning, Cecilia Engdahl
Frontiers in endocrinology - 2023 -
Bazedoxifene does not share estrogens effects on IgG
sialylation
Priti Gupta, Karin Horkeby, Hans Carlsten, Petra Henning, Cecilia Engdahl
Plos One - 2023 -
Physiological estrogen levels are dispensable for the sex difference in immune responses during allergen-induced airway
inflammation
Aidan Barrett, Piotr Humeniuk, Christina Drevinge, Carmen Corciulo, Julie Weidner, Madeleine Rådinger, Hans Carlsten, Julia M. Scheffler, Ulrika Islander
Immunobiology - 2023 -
A tissue-selective estrogen complex as treatment of osteoporosis in experimental
lupus
Jauqueline Nordqvist, Cecilia Engdahl, Julia M. Scheffler, Priti Gupta, Karin L. Gustafsson, Marie K Lagerquist, Hans Carlsten, Ulrika Islander
Lupus - 2022 -
Reduction of Mature B Cells and Immunoglobulins Results in Increased Trabecular
Bone
Marie K Lagerquist, P. Gupta, E. Sehic, Karin L Horkeby, Julia M. Scheffler, Jauqueline Nordqvist, Lina Lawenius, Ulrika Islander, Carmen Corciulo, Petra Henning, Hans Carlsten, Cecilia Engdahl
Jbmr Plus - 2022 -
ER alpha Signaling in a Subset of CXCL12-Abundant Reticular Cells Regulates Trabecular Bone in
Mice
Julia M. Scheffler, Karin L. Gustafsson, Aidan Barrett, Carmen Corciulo, Christina Drevinge, Alicia M. del Carpio Pons, Piotr Humeniuk, Cecilia Engdahl, J. A. Gustafsson, Claes Ohlsson, Hans Carlsten, Marie K Lagerquist, Ulrika Islander
JBMR Plus - 2022 -
Factors associated with changes in volumetric bone mineral density and cortical area in men with ankylosing spondylitis: a 5-year prospective study using
HRpQCT
Anna Deminger, Eva Klingberg, Mattias Lorentzon, M. Hedberg, Hans Carlsten, Lennart T. H. Jacobsson, Helena Forsblad d'Elia
Osteoporosis International - 2022 -
Immunoglobulin G complexes without sialic acids enhance osteoclastogenesis but do not affect arthritis-mediated bone
loss.
Edina Sehic, Anna Westerlund, Marie K Lagerquist, Ulf H Lerner, Hans Carlsten, Petra Henning, Cecilia Engdahl
Scandinavian journal of immunology - 2021 -
Elevated serum level of hepatocyte growth factor predicts development of new syndesmophytes in men with ankylosing
spondylitis
Anna Deminger, Eva Klingberg, Merja Nurkkala, Mats Geijer, Hans Carlsten, Lennart T. H. Jacobsson, Helena Forsblad d'Elia
Rheumatology - 2021 -
Intermediate monocytes correlate with CXCR3(+) Th17 cells but not with bone characteristics in untreated early rheumatoid
arthritis
Christina Drevinge, Julia M. Scheffler, Catalin Koro-Arvidsson, Daniel Sundh, Hans Carlsten, Inger Gjertsson, Catharina Lindholm, Mattias Lorentzon, Anna Rudin, Anna-Karin Hultgård Ekwall, Ulrika Islander
Plos One - 2021 -
Androgen Receptors in Epithelial Cells Regulate Thymopoiesis and Recent Thymic Emigrants in Male
Mice
Anna S K Wilhelmson, Marta Lantero Rodriguez, Inger Johansson, Elin Svedlund Eriksson, Alexandra Stubelius, Susanne Lindgren, Johan Bourghardt Fagman, P. J. Fink, Hans Carlsten, Olov Ekwall, Åsa Tivesten
Frontiers in Immunology - 2020 -
Interleukin 17A: a Janus-faced regulator of
osteoporosis
Julia M. Scheffler, Louise Grahnemo, Cecilia Engdahl, Christina Drevinge, Karin L. Gustafsson, Carmen Corciulo, Lina Lawenius, Y. Iwakura, Klara Sjögren, Marie Lagerquist, Hans Carlsten, Claes Ohlsson, Ulrika Islander
Scientific Reports - 2020 -
Osteoporosis in a murine model of postmenopausal
lupus
Jauqueline Nordqvist, Marie K Lagerquist, Louise Grahnemo, A. Koskela, Ulrika Islander, Hans Carlsten
Lupus - 2020 -
The Rheumatoid Arthritis Risk Gene AIRE Is Induced by Cytokines in Fibroblast-Like Synoviocytes and Augments the Pro-inflammatory
Response
Beatrice Bergström, Christina Lundqvist, Georgios Vasileiadis, Hans Carlsten, Olov Ekwall, Anna-Karin H Ekwall
Frontiers in Immunology - 2019 -
Hepatocyte growth factor is a potential biomarker for osteoproliferation and osteoporosis in ankylosing
spondylitis
Linda Torres, Eva Klingberg, Merja Nurkkala, Hans Carlsten, Helena Forsblad d'Elia
Osteoporosis International - 2019 -
A distinct gut microbiota composition in patients with ankylosing spondylitis is associated with increased levels of fecal
calprotectin
Eva Klingberg, Maria K Magnusson, Hans Strid, Anna Deminger, Arne Ståhl, Johanna Sundin, Magnus Simrén, Hans Carlsten, Lena Öhman, Helena Forsblad d'Elia
Arthritis Research & Therapy - 2019 -
ER alpha expression in T lymphocytes is dispensable for estrogenic effects in
bone
Karin L. Gustafsson, Karin H. Nilsson, Helen H. Farman, Vikte Lionikaite, Petra Henning, Jianyao Wu, Sara H Windahl, Ulrika Islander, Sofia Moverare-Skrtic, Klara Sjögren, Hans Carlsten, Claes Ohlsson, Marie Lagerquist
Journal of Endocrinology - 2018 -
Testosterone Protects Against Atherosclerosis in Male Mice by Targeting Thymic Epithelial
Cells.
Anna S K Wilhelmson, Marta Lantero Rodriguez, Elin Svedlund Eriksson, Inger Johansson, Per Fogelstrand, Alexandra Stubelius, Susanne Lindgren, Johan Bourghardt Fagman, Göran K Hansson, Hans Carlsten, Mikael C I Karlsson, Olov Ekwall, Åsa Tivesten
Arteriosclerosis, thrombosis, and vascular biology - 2018 -
A five-year prospective study of spinal radiographic progression and its predictors in men and women with ankylosing
spondylitis
Anna Deminger, Eva Klingberg, M. Geijer, J. Gothlin, M. Hedberg, E. Rehnberg, Hans Carlsten, Lennart T. H. Jacobsson, Helena Forsblad d'Elia
Arthritis Research & Therapy - 2018 -
Roles of activating functions 1 and 2 of estrogen receptor α in
lymphopoiesis.
Annica Andersson, Sofia Movérare-Skrtic, Angelina I Bernardi, Helen H. Farman, Pierre Chambon, Cecilia Engdahl, Marie Lagerquist, Sara H Windahl, Hans Carlsten, Claes Ohlsson, Ulrika Islander
The Journal of endocrinology - 2018 -
Testosterone is an endogenous regulator of BAFF and splenic B cell
number
Anna S K Wilhelmson, Marta Lantero Rodriguez, Alexandra Stubelius, Per Fogelstrand, Inger Johansson, M. B. Buechler, S. Lianoglou, V. N. Kapoor, Maria E Johansson, Johan Bourghardt Fagman, A. Duhlin, P. Tripathi, Alessandro Camponeschi, B. T. Porse, A. G. Rolink, Hans Nissbrandt, S. J. Turley, Hans Carlsten, Inga-Lill Mårtensson, M. C. I. Karlsson, Åsa Tivesten
Nature Communications - 2018 -
Age-associated B cells expanded in autoimmune mice are memory cells sharing H-CDR3-selected
repertoires
Alaitz Aranburu, Nina Höök, Natalija Gerasimcik, Bjorn Corleis, Weicheng Ren, Alessandro Camponeschi, Hans Carlsten, Ola Grimsholm, Inga-Lill Mårtensson
European Journal of Immunology - 2018 -
Methotrexate inhibits effects of platelet-derived growth factor and interleukin-1β on rheumatoid arthritis fibroblast-like
synoviocytes
Beatrice Bergström, Hans Carlsten, Anna-Karin H Ekwall
Arthritis Research and Therapy - 2018 -
A longitudinal study of fecal calprotectin and the development of inflammatory bowel disease in ankylosing
spondylitis
Eva Klingberg, Hans Strid, Arne Ståhl, Anna Deminger, Hans Carlsten, Lena Öhman, Helena Forsblad d'Elia
Arthritis Research & Therapy - 2017 -
Which measuring site in ankylosing spondylitis is best to detect bone loss and what predicts the decline: results from a 5-year prospective
study
Anna Deminger, Eva Klingberg, Mattias Lorentzon, Mats Geijer, Jan Göthlin, Martin Hedberg, Eva Rehnberg, Hans Carlsten, Lennart T. H. Jacobsson, Helena Forsblad d'Elia
Arthritis Research & Therapy - 2017 -
Ovarian hormones in innate
inflammation
Alexandra Stubelius, Annica Andersson, Ulrika Islander, Hans Carlsten
Immunobiology - 2017 -
Effects of a tissue-selective estrogen complex on B lymphopoiesis and B cell
function
Jauqueline Nordqvist, Angelina I Bernardi, Ulrika Islander, Hans Carlsten
Immunobiology - 2017 -
SERMs have substance-specific effects on bone, and these effects are mediated via ER alpha AF-1 in female
mice
Anna E Börjesson, Helen H. Farman, Sofia Movérare-Skrtic, Cecilia Engdahl, M. C. Antal, A. Koskela, J. Tuukkanen, Hans Carlsten, A. Krust, P. Chambon, Klara Sjögren, Marie K Lagerquist, Sara H Windahl, Claes Ohlsson
American Journal of Physiology-Endocrinology and Metabolism - 2016 -
Selective oestrogen receptor modulators lasofoxifene and bazedoxifene inhibit joint inflammation and osteoporosis in ovariectomised mice with collagen-induced
arthritis.
Annica Andersson, Angelina I Bernardi, Alexandra Stubelius, Merja Nurkkala Karlsson, Claes Ohlsson, Hans Carlsten, Ulrika Islander
Rheumatology (Oxford, England) - 2016 -
Suppression of Experimental Arthritis and Associated Bone Loss by a Tissue-Selective Estrogen
Complex.
Annica Andersson, Angelina I Bernardi, Merja Nurkkala Karlsson, Alexandra Stubelius, Louise Grahnemo, Claes Ohlsson, Hans Carlsten, Ulrika Islander
Endocrinology - 2016 -
Ncf1 affects osteoclast formation but is not critical for postmenopausal bone
loss
Alexandra Stubelius, Annica Andersson, R. Holmdahl, Claes Ohlsson, Ulrika Islander, Hans Carlsten
BMC Musculoskeletal Disorders - 2016 -
IL-17-producing γδT cells are regulated by estrogen during development of experimental
arthritis.
Annica Andersson, Louise Grahnemo, Cecilia Engdahl, Alexandra Stubelius, Marie K Lagerquist, Hans Carlsten, Ulrika Islander
Clinical immunology (Orlando, Fla.) - 2015 -
Androgens regulate bone marrow B lymphopoiesis in male mice by targeting osteoblast-lineage
cells.
Anna S K Wilhelmson, Alexandra Stubelius, Anna E Börjesson, Jianyao Wu, Anna Stern, Stephen Malin, Inga-Lill Mårtensson, Claes Ohlsson, Hans Carlsten, Åsa Tivesten
Endocrinology - 2015 -
Trabecular bone loss in collagen antibody-induced
arthritis
Louise Grahnemo, Annica Andersson, Merja Nurkkala Karlsson, Alexandra Stubelius, Marie K Lagerquist, Mattias Svensson, Claes Ohlsson, Hans Carlsten, Ulrika Islander
Arthritis Research & Therapy - 2015 -
Selective estrogen receptor modulators in T cell development and T cell dependent
inflammation
Angelina I Bernardi, Annica Andersson, Alexandra Stubelius, Louise Grahnemo, Hans Carlsten, Ulrika Islander
Immunobiology - 2015 -
Possible role of lymphocytes in glucocorticoid-induced increase in trabecular bone mineral
density.
Louise Grahnemo, Caroline Jochems, Annica Andersson, Cecilia Engdahl, Claes Ohlsson, Ulrika Islander, Hans Carlsten
The Journal of endocrinology - 2015 -
Effects of lasofoxifene and bazedoxifene on B cell development and
function.
Angelina I Bernardi, Annica Andersson, Louise Grahnemo, Merja Nurkkala Karlsson, Claes Ohlsson, Hans Carlsten, Ulrika Islander
Immunity, inflammation and disease - 2014 -
The effect of estrogen on bone requires ER alpha in nonhematopoietic cells but is enhanced by ER alpha in hematopoietic
cells
Petra Henning, Claes Ohlsson, Cecilia Engdahl, Helen H. Farman, Sara H Windahl, Hans Carlsten, Marie K Lagerquist
American Journal of Physiology-Endocrinology and Metabolism - 2014 -
Biomarkers of Bone Metabolism in Ankylosing Spondylitis in Relation to Osteoproliferation and
Osteoporosis
Eva Klingberg, Merja Nurkkala, Hans Carlsten, Helena Forsblad d'Elia
Journal of Rheumatology - 2014 -
The role of total and cartilage-specific estrogen receptor alpha expression for the ameliorating effect of estrogen treatment on
arthritis.
Cecilia Engdahl, Anna E Börjesson, Huamei Forsman, Annica Andersson, Alexandra Stubelius, Andree Krust, Pierre Chambon, Ulrika Islander, Claes Ohlsson, Hans Carlsten, Marie K Lagerquist
Arthritis research & therapy - 2014 -
Immunomodulation by the estrogen metabolite
2-methoxyestradiol
Alexandra Stubelius, Malin Erlandsson, Ulrika Islander, Hans Carlsten
Clinical Immunology - 2014 -
Role of Androgen and Estrogen Receptors for the Action of Dehydroepiandrosterone
(DHEA)
Cecilia Engdahl, Marie K Lagerquist, Alexandra Stubelius, Annica Andersson, Erik Studer, Claes Ohlsson, Lars Westberg, Hans Carlsten, Helena Forsblad d'Elia
Endocrinology - 2014 -
The estrogen receptor antagonist ICI 182,780 can act both as an agonist and an inverse agonist when estrogen receptor α AF-2 is
modified.
Sofia Movérare-Skrtic, Anna E Börjesson, Helen H. Farman, Klara Sjögren, Sara H Windahl, Marie K Lagerquist, Annica Andersson, Alexandra Stubelius, Hans Carlsten, Jan-Åke Gustafsson, Claes Ohlsson
Proceedings of the National Academy of Sciences of the United States of America - 2014 -
The role of activation functions 1 and 2 of estrogen receptor-alpha for the effects of estradiol and selective estrogen receptor modulators in male
mice
Anna E Börjesson, Helen H. Farman, Cecilia Engdahl, A. Koskela, Klara Sjögren, Jenny Kindblom, Alexandra Stubelius, Ulrika Islander, Hans Carlsten, M. C. Antal, A. Krust, P. Chambon, J. Tuukkanen, Marie K Lagerquist, Sara H Windahl, Claes Ohlsson
Journal of Bone and Mineral Research - 2013 -
Soluble E-cadherin in Systemic Lupus
Erythematosus.
Tao Jin, Katarina Almehed, Yihong Zhu, Hans Carlsten, Helena Forsblad d'Elia
The Journal of rheumatology - 2013 -
Bone microarchitecture in ankylosing spondylitis and the association with bone mineral density, fractures and
syndesmophytes
Eva Klingberg, Mattias Lorentzon, Jan Göthlin, Dan Mellström, Mats Geijer, Claes Ohlsson, Elizabeth J. Atkinson, Sundeep Khosla, Hans Carlsten, Helena Forsblad d'Elia
Arthritis Research & Therapy - 2013 -
Genetic variants in CARD8 but not in NLRP3 are associated with ankylosing
spondylitis
A. Kastbom, Eva Klingberg, D. Verma, Hans Carlsten, Helena Forsblad d'Elia, J. Wesamaa, J. Cedergren, P. Eriksson, P. Soderkvist
Scandinavian Journal of Rheumatology - 2013 -
Cardiac conduction system abnormalities in ankylosing spondylitis: a cross-sectional
study.
Helena Forsblad d'Elia, Hanna Wallberg, Eva Klingberg, Hans Carlsten, Lennart Bergfeldt
BMC musculoskeletal disorders - 2013 -
Periarticular bone loss in antigen-induced
arthritis.
Cecilia Engdahl, Catharina Lindholm, Alexandra Stubelius, Claes Ohlsson, Hans Carlsten, Marie Lagerquist
Arthritis and rheumatism - 2013 -
Estrogen receptor-α expression in neuronal cells affects bone
mass.
Claes Ohlsson, Cecilia Engdahl, Anna E Börjesson, Sara H Windahl, Erik Studer, Lars Westberg, Elias Eriksson, Antti Koskela, Juha Tuukkanen, Andree Krust, Pierre Chambon, Hans Carlsten, Marie Lagerquist
Proceedings of the National Academy of Sciences of the United States of America - 2012 -
Estradiol ameliorates arthritis and protects against systemic bone loss in Staphylococcus aureus infection in
mice
Inger Gjertsson, Erik Kristiansson, Marie Lagerquist, Catharina Lindholm, Hans Carlsten
Arthritis Research & Therapy - 2012 -
Calprotectin in ankylosing spondylitis - Frequently elevated in feces, but normal in
serum
Eva Klingberg, Hans Carlsten, Elisabet Hilme, Martin Hedberg, Helena Forsblad d'Elia
Scandinavian Journal of Gastroenterology - 2012 -
Exosomal secretion of death bullets: a new way of apoptotic
escape?
N. Trokovic, R. Pollanen, P. Porola, V. Stegaev, U. Hetzel, Åsa Tivesten, Cecilia Engdahl, Hans Carlsten, Helena Forsblad d'Elia, Johan Bourghardt Fagman, Marie Lagerquist, Y. T. Konttinen
American Journal of Physiology-Endocrinology and Metabolism - 2012 -
Vertebral fractures in ankylosing spondylitis are associated with lower bone mineral density in both central and peripheral
skeleton.
Eva Klingberg, Mats Geijer, Jan Göthlin, Dan Mellström, Mattias Lorentzon, Elisabet Hilme, Martin Hedberg, Hans Carlsten, Helena Forsblad d'Elia
The Journal of rheumatology - 2012 -
Osteoporosis in ankylosing spondylitis - prevalence, risk factors and methods of
assessment.
Eva Klingberg, Mattias Lorentzon, Dan Mellström, Mats Geijer, Jan Göthlin, Elisabet Hilme, Martin Hedberg, Hans Carlsten, Helena Forsblad d'Elia
Arthritis research & therapy - 2012 -
Sexual dimorphisms in the immune system of catechol-O-methyltransferase knockout
mice
Alexandra Stubelius, Anna S K Wilhelmson, J. A. Gogos, Åsa Tivesten, Ulrika Islander, Hans Carlsten
Immunobiology - 2012 -
Decreased Serum Levels of TGF-β1 are associated with Renal Damages in Female Patients with Systemic Lupus
Erythematosus.
Tao Jin, Katarina Almehed, Hans Carlsten, Helena Forsblad d'Elia
Lupus - 2012 -
Role of 2-methoxyestradiol as inhibitor of arthritis and osteoporosis in a model of postmenopausal rheumatoid
arthritis
Alexandra Stubelius, Emil Andréasson, Anna Karlsson, Claes Ohlsson, Åsa Tivesten, Ulrika Islander, Hans Carlsten
Clinical Immunology - 2011 -
Bone mineral density by digital X-ray radiogrammetry is strongly decreased and associated with joint destruction in long-standing Rheumatoid Arthritis: a cross-sectional
study.
Helena Forsblad d'Elia, Hans Carlsten
BMC musculoskeletal disorders - 2011 -
Effects of oestradiol and raloxifene on the induction and effector phases of experimental postmenopausal arthritis and secondary
osteoporosis
Caroline Jochems, Ulrika Islander, Malin Erlandsson, Cecilia Engdahl, Marie Lagerquist, Claes Ohlsson, Kutty Selva Nandakumar, Rikard Holmdahl, Hans Carlsten
Clinical and Experimental Immunology - 2011 -
Estrogens in rheumatoid arthritis; the immune system and
bone
Ulrika Islander, Caroline Jochems, Marie Lagerquist, Helena Forsblad d'Elia, Hans Carlsten
Molecular and Cellular Endocrinology - 2011 -
Combined treatment with Dexamethasone and Raloxifene totally abrogates osteoporosis and joint destruction in experimental postmenopausal
arthritis
Ulrika Islander, Caroline Jochems, Alexandra Stubelius, Annica Andersson, Marie Lagerquist, Claes Ohlsson, Hans Carlsten
Arthritis Research and Therapy - 2011 -
Serum levels of HMGB1 in postmenopausal patients with rheumatoid arthritis: associations with proinflammatory cytokines, acute-phase reactants, and clinical disease
characteristics.
Rille Pullerits, Vilma Urbonaviciute, Reinhard E Voll, Helena Forsblad d'Elia, Hans Carlsten
The Journal of rheumatology - 2011 -
Hormone replacement therapy in postmenopausal women with rheumatoid arthritis stabilises bone mineral density by digital x-ray radiogrammetry in a randomised controlled
trial.
Helena Forsblad d'Elia, Hans Carlsten
Annals of the rheumatic diseases - 2011 -
Role of endogenous and exogenous female sex hormones in arthritis and osteoporosis development in B10.Q-ncf1*/* mice with collagen-induced chronic
arthritis.
Caroline Jochems, Ulrika Islander, Malin Erlandsson, Cecilia Engdahl, Marie Lagerquist, Inger Gjertsson, Claes Ohlsson, Rikard Holmdahl, Hans Carlsten
BMC musculoskeletal disorders - 2010 -
Amelioration of collagen-induced arthritis and immune-associated bone loss through signaling via estrogen receptor alpha, and not estrogen receptor beta or G protein-coupled receptor
30.
Cecilia Engdahl, Caroline Jochems, Sara H Windahl, Anna E Börjesson, Claes Ohlsson, Hans Carlsten, Marie Lagerquist
Arthritis and rheumatism - 2010 -
Prevalence and risk factors of vertebral compression fractures in female SLE
patients.
Katarina Almehed, Szabolcs Hetenyi, Claes Ohlsson, Hans Carlsten, Helena Forsblad d'Elia
Arthritis research & therapy - 2010 -
Health-related quality of life in systemic lupus erythematosus and its association with disease and work
disability.
Katarina Almehed, Hans Carlsten, Helena Forsblad d'Elia
Scandinavian journal of rheumatology - 2010 -
The decrease of soluble RAGE levels in rheumatoid arthritis patients following hormone replacement therapy is associated with increased bone mineral density and diminished bone/cartilage turnover: a randomized controlled
trial.
Rille Pullerits, Helena Forsblad d'Elia, Andrej Tarkowski, Hans Carlsten
Rheumatology (Oxford, England) - 2009 -
In Vivo activation of gene transcription via estrogen response elements by raloxifene
analogue.
Cecilia Engdahl, Caroline Jochems, Gustafsson, van der Saag, Hans Carlsten, Marie Lagerquist
The Journal of endocrinology - 2009 -
The role of the G protein-coupled receptor GPR30 in the effects of estrogen in ovariectomized
mice.
Sara H Windahl, Niklas Andersson, A S Chagin, U E A Mårtensson, Hans Carlsten, B Olde, Charlotte Swanson, Sofia Movérare-Skrtic, L Sävendahl, Marie Lagerquist, L M F Leeb-Lundberg, Claes Ohlsson
American journal of physiology. Endocrinology and metabolism - 2009 -
Endothelin-1 across the lung circulation in patients with pulmonary arterial hypertension and influence of epoprostenol
infusion.
Nedim Selimovic, Bert Andersson, Claes-Håkan Bergh, Egidija Sakiniene, Hans Carlsten, Bengt Rundqvist
The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation - 2009 -
Low serum levels of sex steroids are associated with disease characteristics in primary Sjogren's syndrome; supplementation with dehydroepiandrosterone restores the
concentrations.
Helena Forsblad d'Elia, Hans Carlsten, Fernand Labrie, Yrjö T Konttinen, Claes Ohlsson
The Journal of clinical endocrinology and metabolism - 2009 -
Growth factors and interleukin-6 across the lung circulation in pulmonary
hypertension.
Nedim Selimovic, Claes-Håkan Bergh, Bert Andersson, Egidija Sakiniene, Hans Carlsten, Bengt Rundqvist
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology - 2009 -
Salivary resistin reflects local inflammation in Sjögrens
syndrome
Elisabeth Almer Boström, Helena Forsblad d'Elia, Ulf Dahlgren, Charlotte Simark-Mattsson, Bengt Hasséus, Hans Carlsten, Andrej Tarkowski, Maria Bokarewa
Journal of Rheumatology - 2008 -
The Impact of Hormone Replacement Therapy on Humoral and Cell-mediated Immune Responses In Vivo in Post-menopausal Women with Rheumatoid
Arthritis
Helena Forsblad d'Elia, Hans Carlsten
Scandinavian Journal of Immunology - 2008 -
Resistin in serum is associated with higher levels of IL-1Ra in post-menopausal women with rheumatoid
arthritis.
Helena Forsblad d'Elia, Rille Pullerits, Hans Carlsten, Maria Bokarewa
Rheumatology (Oxford, England) - 2008 -
Long-term anti-arthritic and anti-osteoporotic effects of raloxifene in established experimental postmenopausal
polyarthritis.
Caroline Jochems, Marie Lagerquist, Cecilia Håkansson, Claes Ohlsson, Hans Carlsten
Clinical and experimental immunology - 2008 -
17Beta-estradiol expands IgA-producing B cells in mice deficient for the mu
chain.
Marie Lagerquist, Malin Erlandsson, L Svensson, Ulrika Islander, R Holmdahl, Hans Carlsten
Scandinavian journal of immunology - 2008 -
Role of resistin as a marker of inflammation in systemic lupus
erythematosus.
Katarina Almehed, Helena Forsblad d'Elia, Maria Bokarewa, Hans Carlsten
Arthritis research & therapy - 2008 -
Ethanol prevents development of destructive
arthritis
Ing-Marie Jonsson, Margareta Verdrengh, Mikael Brisslert, Sofia Silfverswärd Lindblad, Maria Bokarewa, Ulrika Islander, Hans Carlsten, Claes Ohlsson, K. S. Nandakumar, R. Holmdahl, Andrej Tarkowski
Proc Natl Acad Sci U S A - 2007 -
Addition of bisphosphonate to antibiotic and anti-inflammatory treatment reduces bone resorption in experimental Staphylococcus aureus-induced
arthritis
Margareta Verdrengh, Hans Carlsten, Claes Ohlsson, Andrej Tarkowski
J Orthop Res - 2007 -
Identification of Target Cells for the Genomic Effects of Estrogens in
Bone
Sara H Windahl, Marie Lagerquist, Niklas Andersson, Caroline Jochems, Anna Kallkopf, Cecilia Håkansson, J. Inzunza, J. A. Gustafsson, P. T. van der Saag, Hans Carlsten, K. Pettersson, Claes Ohlsson
Endocrinology - 2007 -
Role of raloxifene as a potent inhibitor of experimental postmenopausal polyarthritis and
osteoporosis
Caroline Jochems, Ulrika Islander, Anna Kallkopf, Marie Lagerquist, Claes Ohlsson, Hans Carlsten
Arthritis Rheum - 2007 -
Prevalence and risk factors of osteoporosis in female SLE patients-extended
report
Katarina Almehed, Helena Forsblad d'Elia, G. Kvist, Claes Ohlsson, Hans Carlsten
Rheumatology (Oxford) - 2007 -
Interaction with estrogen receptors as treatment of arthritis and
osteoporosis.
Hans Carlsten
Advances in experimental medicine and biology - 2007 -
Rapid systemic bone resorption during the course of Staphylococcus aureus-induced
arthritis
Margareta Verdrengh, Hans Carlsten, Claes Ohlsson, Andrej Tarkowski
J Infect Dis - 2006 -
Liver-derived IGF-I is permissive for ovariectomy-induced trabecular bone
loss
Marie Lindberg, J. Svensson, K. Venken, Tina Chavoshi, Niklas Andersson, Sofia Movérare-Skrtic, Olle Isaksson, D. Vanderschueren, Hans Carlsten, Claes Ohlsson
Bone - 2006 -
Leukemia inhibitory factor reduces body fat mass in ovariectomized
mice
John-Olov Jansson, Sofia Movérare-Skrtic, Anna Berndtsson, Ingrid Wernstedt, Hans Carlsten, Claes Ohlsson
Eur J Endocrinol - 2006 -
Hormone Replacement Therapy in Rheumatoid
Arthritis
Helena Forsblad d'Elia, Hans Carlsten
Current Rheumatology Reviews - 2006 -
Estren promotes androgen phenotypes in primary lymphoid organs and submandibular
glands
Ulrika Islander, Bengt Hasséus, Malin Erlandsson, Caroline Jochems, Sofia Movérare-Skrtic, Marie Lindberg, J. A. Gustafsson, Claes Ohlsson, Hans Carlsten
BMC Immunology - 2005 -
Estren-mediated inhibition of T lymphopoiesis is estrogen receptor-independent whereas its suppression of T cell-mediated inflammation is estrogen
receptor-dependent
Ulrika Islander, Malin Erlandsson, Tina Chavoshi, Caroline Jochems, Sofia Movérare-Skrtic, S. Nilsson, Claes Ohlsson, J. A. Gustafsson, Hans Carlsten
Clin Exp Immunol - 2005 -
Osteoporosis in experimental postmenopausal polyarthritis: the relative contributions of estrogen deficiency and
inflammation
Caroline Jochems, Ulrika Islander, Malin Erlandsson, Margareta Verdrengh, Claes Ohlsson, Hans Carlsten
Arthritis Res Ther - 2005 -
Investigation of central versus peripheral effects of estradiol in ovariectomized
mice
Niklas Andersson, Ulrika Islander, Emil Egecioglu, Elin Löf, Charlotte Swanson, Sofia Movérare-Skrtic, Klara Sjögren, Marie Lindberg, Hans Carlsten, Claes Ohlsson
J Endocrinol - 2005 -
Estrogenic agonism and antagonism of the soy isoflavone genistein in uterus, bone and lymphopoiesis in
mice
-
Immune responses and bone loss: the estrogen
connection
Hans Carlsten
Immunol Rev - 2005 -
The impact of a new immunomodulator oxo-quinoline-3-carboxamide on the progression of experimental
lupus
Hans Carlsten, Charlotte A Jonsson, Maria Bokarewa, Lena Svensson, Andrej Tarkowski
Int Immunopharmacol - 2004 -
Hormone replacement therapy, calcium and vitamin D3 versus calcium and vitamin D3 alone decreases markers of cartilage and bone metabolism in rheumatoid arthritis: a randomized controlled trial
[ISRCTN46523456]
Helena Forsblad d'Elia, S. Christgau, Lars-Åke Mattsson, T. Saxne, Claes Ohlsson, Elisabeth Nordborg, Hans Carlsten
Arthritis Res Ther - 2004 -
Hormone replacement therapy in rheumatoid arthritis - Drs. Forsblad d'Elia Carlsten
reply
Helena Forsblad d'Elia, Hans Carlsten
JOURNAL OF RHEUMATOLOGY - 2004 -
Hormone replacement therapy in rheumatoid arthritis is associated with lower serum levels of soluble IL-6 receptor and higher insulin-like growth factor
1.
Helena Forsblad d'Elia, Lars-Åke Mattsson, Claes Ohlsson, Elisabeth Nordborg, Hans Carlsten
Arthritis research & therapy - 2003 -
Estren is a selective estrogen receptor modulator with transcriptional
activity.
Sofia Movérare, Johanna Dahllund, Niklas Andersson, Ulrika Islander, Hans Carlsten, Jan-Ake Gustafsson, Stefan Nilsson, Claes Ohlsson
Molecular pharmacology - 2003 -
Oestrogen receptor specificity in oestradiol-mediated effects on B lymphopoiesis and immunoglobulin production in male
mice.
M C Erlandsson, C A Jonsson, Ulrika Islander, Claes Ohlsson, Hans Carlsten
Immunology - 2003 -
Influence of oestrogen receptor alpha and beta on the immune system in aged female
mice.
Ulrika Islander, M C Erlandsson, Bengt Hasséus, C A Jonsson, Claes Ohlsson, J-A Gustafsson, Ulf Dahlgren, Hans Carlsten
Immunology - 2003 -
Influence of hormone replacement therapy on disease progression and bone mineral density in rheumatoid
arthritis.
Helena Forsblad d'Elia, Arvi Larsen, Lars-Åke Mattsson, Eva Waltbrand, Göran Kvist, Dan Mellström, Tore Saxne, Claes Ohlsson, Elisabeth Nordborg, Hans Carlsten
The Journal of rheumatology - 2003 -
Radiographic joint destruction in postmenopausal rheumatoid arthritis is strongly associated with generalised
osteoporosis.
Helena Forsblad d'Elia, A Larsen, Eva Waltbrand, G. Kvist, Dan Mellström, T. Saxne, Claes Ohlsson, Elisabeth Nordborg, Hans Carlsten
Annals of the rheumatic diseases - 2003 -
Interleukin-6-deficient mice develop mature-onset
obesity.
Ville Wallenius, Kristina Wallenius, Bo Ahrén, Mats Rudling, Hans Carlsten, Suzanne L. Dickson, Claes Ohlsson, John-Olov Jansson
Nature medicine - 2002 -
Raloxifene- and estradiol-mediated effects on uterus, bone and B lymphocytes in
mice.
M C Erlandsson, C A Jonsson, Marie K Lindberg, Claes Ohlsson, Hans Carlsten
The Journal of endocrinology - 2002 -
Estrogen receptor specificity for the effects of estrogen in ovariectomized
mice.
Marie K Lindberg, Z Weihua, Niklas Andersson, Sofia Movérare, Hui-Ling Gao, Olle Vidal, M C Erlandsson, Sara H Windahl, G Andersson, D B Lubahn, Hans Carlsten, Karin Dahlman-Wright, J-A Gustafsson, Claes Ohlsson
The Journal of endocrinology - 2002 -
Estrogen receptor alpha, but not estrogen receptor beta, is involved in the regulation of the OPG/RANKL (osteoprotegerin/receptor activator of NF-kappa B ligand) ratio and serum interleukin-6 in male
mice.
Marie K Lindberg, Malin Erlandsson, S L Alatalo, Sara H Windahl, G. Andersson, J M Halleen, Hans Carlsten, J A Gustafsson, Claes Ohlsson
The Journal of endocrinology - 2001 -
Role of oestrogen receptors alpha and beta in immune organ development and in oestrogen-mediated effects on
thymus.
M C Erlandsson, Claes Ohlsson, J A Gustafsson, Hans Carlsten
Immunology - 2001 -
Mycophenolate mofetil ameliorates perivascular T lymphocyte inflammation and reduces the double-negative T cell population in SLE-prone MRLlpr/lpr
mice.
Charlotte A Jonsson, Malin Erlandsson, Lena Svensson, J Mölne, Hans Carlsten
Cellular immunology - 1999