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Johan Bourghardt Fagman
Forskare
Avd för kirurgiOm Johan Bourghardt Fagman
Johan Bourghardt Fagman är biomedicinsk forskare och docent vid Institutionen för kliniska vetenskaper vid Sahlgrenska akademin. Han bedriver translationell cancerforskning vid Forskningsmottagning kirurgi och Sahlgrenska Centrum för Cancerforskning, med huvudsakligt fokus på cancer i bukspottkörteln.
Forskning
Målet med forskningen är att upptäcka nya mekanismer som styr tumörens mikromiljö, tumörfrämjande och terapiresistens, samt vävnadsregenerering och homeostas. I vår forskning arbetar vi med modeller av inflammation och cancer i bukspottkörteln och studerar effekterna av inflammation och cellulära stressreaktioner.
För närvarande är de viktigaste forskningsinriktningarna:
- Autofagins och autofagirelaterade vägars roll i inflammation och cancer i bukspottkörteln
- Betydelsen av cellulära stressreaktioner (t.ex. autofagi, stressreaktiva signalvägar, senescens) för behandlingsresistens vid cancer i bukspottkörteln
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Adjunct mucin biomarkers MUC2+MUC5AC and MUC5AC+PSCA in a clinical setting identify and may improve correct selection of high-risk pancreatic lesions for
surgery.
Eva Philipson, Karolina S. Jabbar, Svein-Olav Bratlie, Gunnar C. Hansson, Jan Persson, Caroline Vilhav, Johanna Wennerblom, Riadh Sadik, Peter Naredi, Johan Bourghardt Fagman, Cecilia Engström
HPB : the official journal of the International Hepato Pancreato Biliary Association - 2025 -
Impact of Surgery-Induced Myeloid-derived Suppressor Cells and the NOX2/ROS Axis on Postoperative Survival in Human Pancreatic
Cancer
Hanna Grauers Wiktorin, Ebru Aydin, Roberta Kiffin, Caroline Vilhav, Johan Bourghardt Fagman, Mustafa Kaya, Sanchari Paul, Beatrice Westman, Svein-Olav Bratlie, Peter Naredi, Kristoffer Hellstrand, Anna Martner
Cancer research communications - 2024 -
Genetics and Therapeutic Responses to Tumor-infiltrating Lymphocyte Therapy of Pancreatic Cancer Patient-derived Xenograft
Models
Caroline Vilhav, Lisa M Nilsson, Joakim Karlsson, Johan Bourghardt Fagman, Daniel Giglio, Cecilia Engström, Peter Naredi, Jonas A Nilsson
HPB - 2023 -
C-reactive Protein Identifies Patients at Risk of Postpancreatectomy
Hemorrhage
Caroline Vilhav, Johan Bourghardt Fagman, Erik Holmberg, Peter Naredi, Cecilia Engström
HPB - 2023 -
A comprehensive review of pancreatic cancer and its therapeutic
challenges
Shan Jiang, Johan Bourghardt Fagman, Yunyun Ma, Jian Liu, C. Vihav, Cecilia Engström, Beidong Liu, Changyan Chen
Aging - 2022 -
Reduced tumor growth in EP2 knockout mice is related to signaling pathways favoring an increase local anti-tumor immunity in the tumor
stroma
Maria Khan, Cecilia Engström, Johan Bourghardt Fagman, Ulrika Smedh, Kent Lundholm, Britt-Marie Iresjö
Oncology Reports - 2022 -
High expression of p62/SQSTM1 predicts shorter survival for patients with pancreatic
cancer
Eva Philipson, Cecilia Engström, Peter Naredi, Johan Bourghardt Fagman
BMC cancer - 2022 -
Deficiency of mature B cells does not alter the atherogenic response to castration in male
mice
Anna S K Wilhelmson, Inger Johansson, Linda Fogelstrand, Johan Bourghardt Fagman, J. F. Arnal, M. C. I. Karlsson, Åsa Tivesten
Scientific Reports - 2022 -
Genetics and Therapeutic Responses to Tumor-Infiltrating
Lymphocyte Therapy of Pancreatic Cancer Patient-Derived
Xenograft
Models
Lisa M Nilsson, Caroline Vilhav, Joakim Karlsson, Johan Bourghardt Fagman, Daniel Giglio, Cecilia Engström, Peter Naredi, Jonas A Nilsson
Gastro Hep Advances - 2022 -
C-reactive protein identifies patients at risk of postpancreatectomy
hemorrhage
Caroline Vilhav, Johan Bourghardt Fagman, E Holmberg, Peter Naredi, Cecilia Engström
Langenbeck's archives of surgery - 2022 -
Androgen Receptors in Epithelial Cells Regulate Thymopoiesis and Recent Thymic Emigrants in Male
Mice
Anna S K Wilhelmson, Marta Lantero Rodriguez, Inger Johansson, Elin Svedlund Eriksson, Alexandra Stubelius, Susanne Lindgren, Johan Bourghardt Fagman, P. J. Fink, Hans Carlsten, Olov Ekwall, Åsa Tivesten
Frontiers in Immunology - 2020 -
Protein phase separation and its role in
tumorigenesis
Shan Jiang, Johan Bourghardt Fagman, Changyan Chen, Simon Alberti, Beidong Liu
eLife - 2020 -
EGFR, but not COX-2, protein in resected pancreatic ductal adenocarcinoma is associated with poor
survival.
Johan Bourghardt Fagman, David Ljungman, Peter Falk, Britt-Marie Iresjö, Cecilia Engström, Peter Naredi, Kent Lundholm
Oncology letters - 2019 -
p62/SQSTM1 accumulation is associated with poor patient survival in resected pancreatic ductal
adenocarcinoma
Eva Philipson, Cecilia Engström, Peter Naredi, Johan Bourghardt Fagman
4th Swedish Cancer Research Meeting – Gothenburg, Gothenburg, Sweden - 2019 -
Testosterone is an endogenous regulator of BAFF and splenic B cell
number
Anna S K Wilhelmson, Marta Lantero Rodriguez, Alexandra Stubelius, Per Fogelstrand, Inger Johansson, M. B. Buechler, S. Lianoglou, V. N. Kapoor, Maria E Johansson, Johan Bourghardt Fagman, A. Duhlin, P. Tripathi, Alessandro Camponeschi, B. T. Porse, A. G. Rolink, Hans Nissbrandt, S. J. Turley, Hans Carlsten, Inga-Lill Mårtensson, M. C. I. Karlsson, Åsa Tivesten
Nature Communications - 2018 -
Testosterone Protects Against Atherosclerosis in Male Mice by Targeting Thymic Epithelial
Cells.
Anna S K Wilhelmson, Marta Lantero Rodriguez, Elin Svedlund Eriksson, Inger Johansson, Per Fogelstrand, Alexandra Stubelius, Susanne Lindgren, Johan Bourghardt Fagman, Göran K Hansson, Hans Carlsten, Mikael C I Karlsson, Olov Ekwall, Åsa Tivesten
Arteriosclerosis, thrombosis, and vascular biology - 2018 -
Fractional uptake of circulating tumor cells into liver-lung compartments during curative resection of periampullary
cancer.
Caroline Vilhav, Cecilia Engström, Peter Naredi, Ann Novotny, Johan Bourghardt Fagman, Britt-Marie Iresjö, Annika Gustafsson Asting, Kent Lundholm
Oncology letters - 2018 -
Stress-Activated NRF2-MDM2 Cascade Controls Neoplastic Progression in
Pancreas.
Jelena Todoric, Laura Antonucci, Giuseppe Di Caro, Ning Li, Xuefeng Wu, Nikki K Lytle, Debanjan Dhar, Sourav Banerjee, Johan Bourghardt Fagman, Cecille D Browne, Atsushi Umemura, Mark A Valasek, Hannes Kessler, David Tarin, Michael Goggins, Tannishtha Reya, Maria Diaz-Meco, Jorge Moscat, Michael Karin
Cancer cell - 2017 -
Increased Intimal Hyperplasia After Vascular Injury in Male Androgen Receptor-Deficient
Mice
Anna S K Wilhelmson, Johan Bourghardt Fagman, Inger Johansson, Zhiyuan V. Zou, Axel G Andersson, Elin Svedlund Eriksson, Maria E Johansson, Per Lindahl, Per Fogelstrand, Åsa Tivesten
Endocrinology - 2016 -
Low doses of arsenic, via perturbing p53, promotes
tumorigenesis.
Suthakar Ganapathy, Ping Li, Johan Bourghardt Fagman, Tianqi Yu, Jean Lafontant, Guojun Zhang, Changyan Chen
Toxicology and applied pharmacology - 2016 -
Ral A, via activating the mitotic checkpoint, sensitizes cells lacking a functional Nf1 to apoptosis in the absence of protein kinase
C.
Suthakar Ganapathy, Johan Bourghardt Fagman, Ling Shen, Tianqi Yu, Xiaodong Zhou, Wei Dai, Alexandros Makriyannis, Changyan Chen
Oncotarget - 2016 -
The Bone Sparing Effects of 2-Methoxyestradiol Are Mediated via Estrogen Receptor-α in Male
Mice.
Anna-Lena Eriksson, Anna S K Wilhelmson, Johan Bourghardt Fagman, Henrik Ryberg, Antti Koskela, Juha Tuukkanen, Åsa Tivesten, Claes Ohlsson
Endocrinology - 2016 -
Basal autophagy maintains pancreatic acinar cell homeostasis and protein synthesis and prevents ER
stress.
Laura Antonucci, Johan Bourghardt Fagman, Ju Youn Kim, Jelena Todoric, Ilya Gukovsky, Mason Mackey, Mark H Ellisman, Michael Karin
Proceedings of the National Academy of Science of the United States of America - 2015 -
The androgen receptor confers protection against diet-induced atherosclerosis, obesity, and dyslipidemia in female
mice.
Johan Bourghardt Fagman, Anna S K Wilhelmson, Benedetta Maria Motta, Carlo Pirazzi, Camilla Alexanderson, Karel De Gendt, Guido Verhoeven, Agneta Holmäng, Fredrik Anesten, John-Olov Jansson, Malin Levin, Jan Borén, Claes Ohlsson, Alexandra Krettek, Stefano Romeo, Åsa Tivesten
FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 2015 -
Modulation of autophagy and lysosomal function – a possible pathway for treatment of pancreatic
cancer?
Johan Bourghardt Fagman, Peter Naredi
3rd Swedish Cancer Research Meeting, Stockholm, Sweden - 2014 -
Exosomal secretion of death bullets: a new way of apoptotic
escape?
N. Trokovic, R. Pollanen, P. Porola, V. Stegaev, U. Hetzel, Åsa Tivesten, Cecilia Engdahl, Hans Carlsten, Helena Forsblad d'Elia, Johan Bourghardt Fagman, Marie Lagerquist, Y. T. Konttinen
American Journal of Physiology-Endocrinology and Metabolism - 2012 -
Accelerated atherosclerosis in female mice lacking the androgen
receptor
Johan Bourghardt Fagman, Anna S K Wilhelmson, Camilla Alexanderson, K De Gendt, G Verhoeven, Agneta Holmäng, Alexandra Krettek, Sven-Olof Olofsson, Claes Ohlsson, Åsa Tivesten
Atherosclerosis Supplements, Volume 12, Issue 1, 2011, Page 64 - 2011 -
Catechol-O-methyltransferase is dispensable for vascular protection by estradiol in mouse models of atherosclerosis and neointima
formation.
Anna S K Wilhelmson, Johan Bourghardt Fagman, Joseph A Gogos, Per Fogelstrand, Åsa Tivesten
Endocrinology - 2011 -
Accelerated atherosclerosis associated with hypertriglyceridemia, insulin resistance and obesity in female mice lacking the androgen
receptor
Johan Bourghardt Fagman, Anna S K Wilhelmson, Camilla Alexanderson, K De Gendt, G Verhoeven, Agneta Holmäng, Alexandra Krettek, Claes Ohlsson, Åsa Tivesten
Endocrine Reviews, Supplement 1, June 2010, 31[3]: S873 - 2010 -
Actions of androgens and estrogens in experimental models of cardiovascular
disease
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Androgen receptor-dependent and independent atheroprotection by testosterone in male
mice.
Johan Bourghardt Fagman, Anna S K Wilhelmson, Camilla Alexanderson, Karel De Gendt, Guido Verhoeven, Alexandra Krettek, Claes Ohlsson, Åsa Tivesten
Endocrinology - 2010 -
The androgen receptor is involved in gonadal atheroprotection in both male and female
mice
Johan Bourghardt Fagman, Anna S K Wilhelmson, K De Gendt, G Verhoeven, Alexandra Krettek, Claes Ohlsson, Åsa Tivesten
15th Annual Scandinavian Atherosclerosis Conference. Humlebaek, Denmark - 2009 -
The androgen receptor is involved in gonadal atheroprotection in both male and female
mice
Johan Bourghardt Fagman, Anna S K Wilhelmson, K De Gendt, G Verhoeven, Alexandra Krettek, Claes Ohlsson, Åsa Tivesten
Atherosclerosis Supplements, Volume 10, Issue 2, 2009, Page e476 - 2009 -
Possible mechanisms for the anti-atherogenic effect of the estradiol metabolite
2-methoxyestradiol
Johan Bourghardt Fagman, Lillemor Mattsson Hultén, Sara Sjöberg, Alexandra Krettek, Åsa Tivesten
14th Annual Scandinavian Atheroclserosis Conference, Humlebæk, Denmark - 2008 -
The endogenous estradiol metabolite 2-methoxyestradiol reduces atherosclerotic lesion formation in female apolipoprotein E-deficient
mice
Johan Bourghardt Fagman, Göran Bergström, Alexandra Krettek, Sara Sjöberg, Jan Borén, Åsa Tivesten
Endocrinology - 2007