Mode of action of natural products in pathogenic Gram negative bacteria and their development as antibacterial agents

The global increase in antibiotics resistance calls for action on multiple fronts, one of which is to find new candidate antibiotics. Very few of these currently come out world-wide of the drug discovery pipeline. Trying to contribute to this effort, and potentially finding antibacterial molecules with new modes of action, we screen collections of molecules from tropical plants for antibacterial activity. Of particular interest are molecules active against Gram-negative bacteria.