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Håkan Billig
Seniorforskare
Sektionen för fysiologiOm Håkan Billig
Research group
Physiology of the Fallopian Tube and Ectopic Pregnancy
Research interest
Female reproductive endocrinology has remained my primary research interest throughout my research career I have had the opportunity to work on several levels: molecular, cellular, systemic and both in experimental animal models as well in clinical settings and patient materials.
My research focus has developed based on the knowledge we have acquired and in parallel with the fast evolving international research in our and adjacent fields of research and with introduction of new techniques:
- ovarian metabolism (-1988)
- growth factor and GH effects on reproduction (1988-1995)
- follicular development and gonadal apoptosis (1990-2009)
- function of and metabolic regulation by prolactin on metabolism (2000-2011)
- progesterone and estrogen receptor subtype regulation and function in reproductive tissues (2003-2012)
- Fallopian tube physiology and tubal ectopic pregnancy (2006-2012)
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Regulatory mechanisms of HMGB1 and its receptors in polycystic ovary syndrome-driven gravid uterine
inflammation.
Min Hu, Yuehui Zhang, Yaxing Lu, Jing Han, Tingting Guo, Peng Cui, Mats Brännström, Linus Ruijin Shao, Håkan Billig
The FEBS journal - 2023 -
Defective uterine spiral artery remodelling and placental senescence in a pregnant rat model of polycystic ovary
syndrome.
Min Hu, Yuehui Zhang, Xu Zhang, XiuYing Zhang, Xinyue Huang, Yaxing Lu, Yijia Li, Mats Brännström, Amanda Nancy Sferruzzi-Perri, Linus Ruijin Shao, Håkan Billig
The American journal of pathology - 2023 -
Person-centered care content in medicine, occupational therapy, nursing, and physiotherapy education
programs
Catarina Wallengren Gustafsson, Håkan Billig, Ida Björkman, Inger Ekman, Caroline Feldthusen, Irma Lindström Kjellberg, Mari Lundberg
BMC medical education - 2022 -
Overactivation of the androgen receptor exacerbates gravid uterine ferroptosis via interaction with and suppression of the NRF2 defense signaling
pathway.
Min Hu, Yuehui Zhang, Lingjing Lu, Yu Zhou, Denghui Wu, Mats Brännström, Linus Ruijin Shao, Håkan Billig
FEBS letters - 2022 -
Suppression of uterine and placental ferroptosis by N-acetylcysteine in a rat model of polycystic ovary
syndrome.
Min Hu, Yuehui Zhang, Shuting Ma, Juanli Li, Xu Wang, Mengmeng Liang, Amanda Nancy Sferruzzi-Perri, Xiaoke Wu, Hongxia Ma, Mats Brännström, Linus Ruijin Shao, Håkan Billig
Molecular human reproduction - 2021 -
Increased uterine androgen receptor protein abundance results in implantation and mitochondrial defects in pregnant rats with hyperandrogenism and insulin
resistance.
Yuehui Zhang, Min Hu, Fan Yang, Yizhuo Zhang, Shuting Ma, Dongqi Zhang, Xu Wang, Amanda Nancy Sferruzzi-Perri, Xiaoke Wu, Mats Brännström, Linus Ruijin Shao, Håkan Billig
Journal of molecular medicine (Berlin, Germany) - 2021 -
Long-term androgen excess induces insulin resistance and non-alcoholic fatty liver disease in PCOS-like
rats.
Peng Cui, Wei Hu, Tong Ma, Min Hu, Xiaoyu Tong, Feifei Zhang, Jiemei Shi, Xiaoqing Xu, Xin Li, Linus Ruijin Shao, Håkan Billig, Yi Feng
The Journal of steroid biochemistry and molecular biology - 2021 -
TLR4-associated IRF-7 and NFĸB signaling acts as a molecular link between androgen and metformin activities and cytokine synthesis in the PCOS
endometrium.
Min Hu, Yuehui Zhang, Xin Li, Peng Cui, Amanda Nancy Sferruzzi-Perri, Mats Brännström, Linus Ruijin Shao, Håkan Billig
The Journal of clinical endocrinology and metabolism - 2021 -
Long-term androgen-induced nonalcoholic fatty liver disease in a polycystic ovary syndrome mouse model is related to mitochondrial
dysfunction
P. Cui, J. M. Shi, T. Ma, L. Rao, X. Y. Tong, W. Hu, X. Q. Xu, F. F. Zhang, X. Li, Håkan Billig, L. R. Shao, Y. Feng
Reproductive and Developmental Medicine - 2021 -
Hyperandrogenism and insulin resistance modulate gravid uterine and placental ferroptosis in PCOS-like
rats.
Yuehui Zhang, Min Hu, Wenyan Jia, Guoqi Liu, Jiao Zhang, Bing Wang, Juan Li, Peng Cui, Xin Li, Susanne Lager, Amanda N Sferruzzi-Perri, Yanhua Han, Songjiang Liu, Xiaoke Wu, Mats Brännström, Linus Ruijin Shao, Håkan Billig
The Journal of endocrinology - 2020 -
Alterations of endometrial epithelial-mesenchymal transition and MAPK signaling components in women with PCOS are partially modulated by metformin in
vitro.
Min Hu, Yuehui Zhang, Xin Li, Peng Cui, Juan Li, Mats Brännström, Linus Ruijin Shao, Håkan Billig
Molecular human reproduction - 2020 -
Hyperandrogenism and insulin resistance induce gravid uterine defects in association with mitochondrial dysfunction and aberrant ROS
production.
Min Hu, Yuehui Zhang, Xiaozhu Guo, Wenyan Jia, Guoqi Liu, Jiao Zhang, Juan Li, Peng Cui, Amanda Nancy Sferruzzi-Perri, Yanhua Han, Xiaoke Wu, Hongxia Ma, Mats Brännström, Linus Ruijin Shao, Håkan Billig
American journal of physiology. Endocrinology and metabolism - 2019 -
Differential Expression Patterns of Glycolytic Enzymes and Mitochondria-Dependent Apoptosis in PCOS Patients with Endometrial Hyperplasia, an Early Hallmark of Endometrial Cancer, In Vivo and the Impact of Metformin In
Vitro.
Tao Wang, Jiao Zhang, Min Hu, Yuehui Zhang, Peng Cui, Xin Li, Juan Li, Edvin Vestin, Mats Brännström, Linus Ruijin Shao, Håkan Billig
International journal of biological sciences - 2019 -
Uterine glycolytic enzyme expression is affected by knockout of different estrogen receptor
subtypes.
Min Hu, Yuehui Zhang, Emil Egecioglu, Xin Li, Linus Ruijin Shao, Håkan Billig
Biomedical reports - 2019 -
Hyperandrogenism and insulin resistance-induced fetal loss: evidence for placental mitochondrial abnormalities and elevated ROS production in pregnant rats that mimic the clinical features of
PCOS.
Yuehui Zhang, Wei Zhao, Hongfei Xu, Min Hu, Xiaozhu Guo, Wenyan Jia, Guoqi Liu, Juan Li, Peng Cui, Susanne Lager, Amanda Nancy Sferruzzi-Perri, Wei Li, Xiao-Ke Wu, Yanhua Han, Mats Brännström, Linus Ruijin Shao, Håkan Billig
The Journal of physiology - 2019 -
Perturbed ovarian and uterine glucocorticoid receptor signaling accompanies the balanced regulation of mitochondrial function and NFκB-mediated inflammation under conditions of hyperandrogenism and insulin
resistance.
Min Hu, Yuehui Zhang, Xiaozhu Guo, Wenyan Jia, Guoqi Liu, Jiao Zhang, Peng Cui, Juan Li, Wei Li, Xiaoke Wu, Hongxia Ma, Mats Brännström, Linus Ruijin Shao, Håkan Billig
Life sciences - 2019 -
Endometrial progesterone receptor isoforms in women with polycystic ovary
syndrome
Min Hu, Juan Li, Yuehui Zhang, Xin Li, Mats Brännström, Linus Ruijin Shao, Håkan Billig
American Journal of Translational Research - 2018 -
Uterine progesterone signaling is a target for metformin therapy in PCOS-like
rats.
Min Hu, Yuehui Zhang, Jiaxing Feng, Xue Xu, Jiao Zhang, Wei Zhao, Xiaozhu Guo, Juan Li, Edvin Vestin, Peng Cui, Xin Li, Xiao-Ke Wu, Mats Brännström, Linus Ruijin Shao, Håkan Billig
The Journal of endocrinology - 2018 -
Hyperandrogenism and insulin resistance contribute to hepatic steatosis and inflammation in female rat
liver.
Yuehui Zhang, Fanci Meng, Xiaoyan Sun, Xue Sun, Min Hu, Peng Cui, Edvin Vestin, Xin Li, Wei Li, Xiao-Ke Wu, John-Olov Jansson, Linus Ruijin Shao, Håkan Billig
Oncotarget - 2018 -
Metformin Ameliorates Uterine Defects in a Rat Model of Polycystic Ovary
Syndrome.
Yuehui Zhang, Min Hu, Fanci Meng, Xiaoyan Sun, Hongfei Xu, Jiao Zhang, Peng Cui, Njomeza Morina, Xin Li, Wei Li, Xiao-Ke Wu, Mats Brännström, Linus Ruijin Shao, Håkan Billig
EBioMedicine - 2017 -
Maternal testosterone and placental function: Effect of electroacupuncture on placental expression of angiogenic markers and fetal
growth
R. Fornes, M. Hu, M. Maliqueo, Milana Kokosar, Anna Benrick, D. Carr, Håkan Billig, T. Jansson, L. Manni, E. Stener-Victorin
Molecular and Cellular Endocrinology - 2016 -
Molecular characterization of insulin resistance and glycolytic metabolism in the rat
uterus.
Yuehui Zhang, Xue Sun, Xiaoyan Sun, Fanci Meng, Min Hu, Xin Li, Wei Li, Xiao-Ke Wu, Mats Brännström, Linus Ruijin Shao, Håkan Billig
Scientific reports - 2016 -
Quantitative analysis of hormones and inflammatory cytokines in Chlamydia trachomatis-infected women with tubal ectopic pregnancy and early intrauterine
pregnancy
Linus Ruijin Shao, Yi Feng, S. Zou, Xin Li, P. Cui, Håkan Billig
Data in Brief - 2016 -
Regulation of androgen receptor expression alters AMPK phosphorylation in the endometrium: In Vivo and In Vitro studies in women with polycystic ovary
syndrome
Xin Li, Bano Pishdari, P. Cui, Min Hu, H.P. Yang, Y.R. Guo, H.Y. Jiang, Yi Feng, Håkan Billig, Linus Ruijin Shao
International Journal of Biological Sciences - 2015 -
Lack of cyclical fluctuations of endometrial GLUT4 expression in women with polycystic ovary syndrome: Evidence for direct regulation of GLUT4 by steroid
hormones
Peng Cui, Xin Li, Xiaoqin Wang, Yi Feng, Jin-Fang Lin, Håkan Billig, Linus Ruijin Shao
BBA Clinical - 2015 -
Reversing the reduced level of endometrial GLUT4 expression in polycystic ovary syndrome: a mechanistic study of metformin
action.
Xin Li, Peng Cui, Hong-Yuan Jiang, Yan-Rong Guo, Bano Pishdari, Min Hu, Yi Feng, Håkan Billig, Linus Ruijin Shao
American journal of translational research - 2015 -
Progesterone-mediated effects on gene expression and oocyte-cumulus complex transport in the mouse fallopian
tube.
Anna Bylander, Lina-Maria Gunnarsson, Linus Ruijin Shao, Håkan Billig, D. G. Joakim Larsson
Reproductive biology and endocrinology : RB&E - 2015 -
The regulation of nitric oxide synthase isoform expression in mouse and human fallopian tubes: Potential insights for ectopic
pregnancy
Junting Hu, S. Ma, S. Zou, X. Li, P. Cui, Birgitta Weijdegård, G. Wu, Linus Ruijin Shao, Håkan Billig, Yi Feng
International Journal of Molecular Sciences - 2015 -
Promising clinical practices of metformin in women with PCOS and early-stage endometrial
cancer
Linus Ruijin Shao, X. Li, Håkan Billig
BBA Clinical - 2014 -
The onset of human ectopic pregnancy demonstrates a differential expression of miRNAs and their cognate targets in the Fallopian
tube
Yi Feng, S. Zou, Birgitta Weijdegård, J. Chen, Q. Cong, Julia Fernandez-Rodriguez, L. Wang, Håkan Billig, Linus Ruijin Shao
International Journal of Clinical and Experimental Pathology - 2014 -
Endometrial progesterone resistance and
PCOS
Xin Li, Yi Feng, Jin-Fang Lin, Håkan Billig, Linus Ruijin Shao
Journal of Biomedical Science. 2014 Jan 09;21(1):2 - 2014 -
Pregnancy after allogeneic uterus transplantation in the rat: perinatal outcome and growth
trajectory.
César Diaz-Garcia, Liza Johannesson, Linus Ruijin Shao, Håkan Billig, Mats Brännström
Fertility and sterility - 2014 -
The elusive and controversial roles of estrogen and progesterone receptors in human
endometriosis
Linus Ruijin Shao, S. Cao, Xiaoyang Wang, Yi Feng, Håkan Billig
American Journal of Translational Research - 2014 -
Direct effects of metformin in the endometrium: a hypothetical mechanism for the treatment of women with PCOS and endometrial
carcinoma
Linus Ruijin Shao, Xin Li, Yi Feng, Jin-Fang Lin, Håkan Billig
Journal of Experimental & Clinical Cancer Research - 2014 -
Burnout is associated with elevated prolactin levels in men but not in
women
Anna-Karin Lennartsson, Håkan Billig, Ingibjörg H Jonsdottir
Journal of Psychosomatic Research - 2014 -
Combination of Diane-35 and Metformin to Treat Early Endometrial Carcinoma in PCOS Women with Insulin
Resistance
Xin Li, Y. R. Guo, J. F. Lin, Yi Feng, Håkan Billig, Linus Ruijin Shao
Journal of Cancer - 2014 -
Electrical vs Manual Acupuncture Stimulation in a Rat Model of Polycystic Ovary Syndrome: Different Effects on Muscle and Fat Tissue Insulin
Signaling
Julia Johansson, Louise Mannerås Holm, Linus Ruijin Shao, AnneLiese Magnusson-Olsson, Malin Lönn, Håkan Billig, Elisabet Stener-Victorin
PLOS ONE - 2013 -
The inflammatory regulation of tubal β-catenin expression in human ectopic pregnancy: is it too early to propose a cause-and-effect
relationship?
Linus Ruijin Shao, Yi Feng, S. Zou, Xin Li, Håkan Billig
Human reproduction (Oxford, England) - 2013 -
Toward understanding Chlamydia infection-induced infertility caused by dysfunctional
oviducts.
Linus Ruijin Shao, Junting Hu, Håkan Billig
The Journal of infectious diseases - 2013 -
Linking DNA methylation to the onset of human tubal ectopic
pregnancy.
Lei Wang, Yi Feng, Shien Zou, Mats Brännström, Lin He, Håkan Billig, Linus Ruijin Shao
American journal of translational research - 2013 -
Aberrant alteration of vascular endothelial growth factor-family signaling in human tubal ectopic pregnancy: what is known and
unknown?
Linus Ruijin Shao, Junting Hu, Yi Feng, Håkan Billig
International Journal of Clinical and Experimental Pathology - 2013 -
The classical progesterone receptor mediates the rapid reduction of fallopian tube ciliary beat frequency by
progesterone.
Anna Bylander, Karin Lind, Mattias Goksör, Håkan Billig, D. G. Joakim Larsson
Reproductive biology and endocrinology : RB&E - 2013 -
Comparison of the diagnostic values of circulating steroid hormones, VEGF-A, PIGF, and ADAM12 in women with ectopic
pregnancy.
Shien Zou, Xin Li, Yi Feng, Shan Sun, Jin Li, Emil Egecioglu, Håkan Billig, Linus Ruijin Shao
Journal of translational medicine - 2013 -
Revealing the Hidden Mechanisms of Smoke-Induced Fallopian Tubal
Implantation.
Linus Ruijin Shao, Shien Zou, Xiaoqin Wang, Yi Feng, Mats Brännström, Elisabet Stener-Victorin, Håkan Billig
Biology of reproduction - 2012 -
The role of estrogen in the pathophysiology of tubal ectopic
pregnancy
Linus Ruijin Shao, Yi Feng, S. E. Zou, Birgitta Weijdegård, G. C. Wu, Mats Brännström, Håkan Billig
American Journal of Translational Research - 2012 -
Coordinate regulation of heterogeneous nuclear ribonucleoprotein dynamics by steroid hormones in the human Fallopian tube and endometrium in vivo and in
vitro.
Linus Ruijin Shao, Xiaoqin Wang, Birgitta Weijdegård, Anders Norström, Julia Fernandez-Rodriguez, Mats Brännström, Håkan Billig
American journal of physiology. Endocrinology and metabolism - 2012 -
From mice to women and back again: Causalities and clues for Chlamydia-induced tubal ectopic
pregnancy.
Linus Ruijin Shao, Xiaoqin Wang, Wei Wang, Elisabet Stener-Victorin, Carina Mallard, Mats Brännström, Håkan Billig
Fertility and sterility - 2012 -
Sex steroid levels temporarily increase in response to acute psychosocial stress in healthy men and
women
Anna-Karin Lennartsson, M. M. Kushnir, Jonas Bergquist, Håkan Billig, Ingibjörg H Jonsdottir
International Journal of Psychophysiology - 2012 -
Electrical and manual acupuncture stimulation affect oestrous cyclicity and neuroendocrine function in an 5α-dihydrotestosterone-induced rat polycystic ovary syndrome
model.
Yi Feng, Julia Johansson, Louise Mannerås Holm, Linus Ruijin Shao, Håkan Billig, Elisabet Stener-Victorin
Experimental physiology - 2012 -
A common variant near the PRL gene is associated with increased adiposity in
males
Louise Nilsson, Anders Olsson, Bo Isomaa, Leif Groop, Håkan Billig, Charlotte Ling
Molecular Genetics and Metabolism - 2011
Fler publikationer
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