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Jan Lycke
Forskare
Sektionen för klinisk neurovetenskapAnknuten till forskning
Sektionen för klinisk neurovetenskap-
Cerebrospinal fluid alpha-internexin is increased in patients with multiple sclerosis and correlates strongly with neurofilament light
protein.
Magnus Johnsson, Meda Fj, Jan Lycke, Lenka Nováková Nyrén, Igal Rosenstein, Johansson K, Clas Malmeström, Henrik Zetterberg, Hlin Kvartsberg, Markus Axelsson
Multiple Sclerosis and Related Disorders - 2025 -
Twenty years of natalizumab in multiple sclerosis: lessons learned and future
outlook
Luisa Klotz, Thomas Berger, Wallace J. Brownlee, Andrew Chan, Jan Lycke, Celia Oreja-Guevara, Filipe Palavra, Francesco Sacca, Tobias Sejbaek, Martin S. Weber, Gavin Giovannoni
Therapeutic Advances in Neurological Disorders - 2025 -
Lymphocyte Dynamics and the Emergence of Secondary Autoimmunity Following Immune Reconstitution Therapies in Multiple
Sclerosis
Sofia Sandgren, Lenka Nováková Nyrén, Markus Axelsson, Igal Rosenstein, Jan Lycke, Clas Malmeström
NEUROLOGY-NEUROIMMUNOLOGY & NEUROINFLAMMATION - 2025 -
The value of CSF diagnostic and prognostic biomarkers in NMOSD and MOGAD in real-life
use.
Magnus Johnsson, Kajsa Eriksson, Igal Rosenstein, Lenka Nováková Nyrén, Clas Malmeström, Jan Lycke, Sofia Sandgren, Henrik Zetterberg, Kaj Blennow, Kalle Johansson, Markus Axelsson
Multiple Sclerosis and Related Disorders - 2025 -
Prognostic Factors for Multiple Sclerosis Symptoms in Radiologically Isolated
Syndrome
Nicolas Fissolo, Sabine Schaedelin, Luisa M. Villar, Jan D. Lunemann, Jorge Correale, Konrad Rejdak, Nicholas Schwab, Andreu Vilaseca, Friederike Held, Antonio Garcia-Merino, Stefan Bittner, Maria Trojano, Roberto Furlan, Hayrettin Tumani, Francisco Perez-Miralles, Igal Rosenstein, Daniela Galimberti, Gary Alvarez-Bravo, Eric Thouvenot, Sara Llufriu, Samia J. Khoury, Robert Hoepner, Sergio Martinez-Yelamos, Harald Hegen, Jelena Drulovic, Neus Tellez-Lara, Michael Khalil, Johanna Oechtering, Angel Perez-Sempere, Alfredo Rodriguez-Antiguedad, Jose Enrique-Martinez, Eva Strijbis, Joep Killestein, Sara Eichau, Elena Colombo, Jonas Schaller-Nagengast, Luciana Midaglia, Antonio J. Sanchez-Lopez, Enric Monreal, Andrew Chan, Friedemann Paul, Alex Rovira, Mar Tintore, Jan Lycke, Frauke Zipp, Bernhard Hemmer, Jens Kuhle, Xavier Montalban, Manuel Comabella
JAMA NEUROLOGY - 2025 -
Brain-Derived Tau as an Outcome Marker in Guillain-Barré Syndrome: A Retrospective Cohort
Study
Brynhildur Hafsteinsdottir, Fernando Gonzalez-Ortiz, Nina Gleisner, Ellen Alpsten, Jan Lycke, Igal Rosenstein, Lenka Novakova, Kaj Blennow, Tomas Bergström, Henrik Zetterberg, Markus Axelsson
EUROPEAN JOURNAL OF NEUROLOGY - 2025 -
Quality of life is decreased in persons with relapsing-remitting multiple sclerosis experiencing progression independent of relapse
activity
Sarah Lindberg, Sofia Sandgren, Markus Axelsson, Igal Rosenstein, Jan Lycke, Lenka Novakova
MULTIPLE SCLEROSIS JOURNAL - 2025 -
Increased EBNA1-specific antibody response in primary-progressive multiple
sclerosis
Manuel Comabella, Harald Hegen, Luisa M. Villar, Konrad Rejdak, Augusto Sao-Avilés, Malina Behrens, Jaume Sastre-Garriga, Neus Mongay, Klaus Berek, Sergio Martínez-Yelamos, Francisco Pérez-Miralles, Ahmed Abdelhak, Franziska Bachhuber, Hayrettin Tumani, Jan Lycke, Pere Carbonell-Mirabent, Adrián Valls-Carbó, Igal Rosenstein, Roberto Alvarez-Lafuente, Tamara Castillo-Triviño, David Otaegui, Sara Llufriu, Yolanda Blanco, Antonio J. Sánchez-López, Antonio García-Merino, Nicolás Fissolo, Lucía Gutiérrez, Javier Villacieros-Álvarez, Enric Monreal, Heinz Wiendl, Xavier Montalban, Jan D. Lünemann
Journal of Neurology - 2025 -
IgG and kappa free light chain CSF/serum indices: evaluating intrathecal immunoglobulin production in HIV infection in comparison with multiple
sclerosis.
Lars Hagberg, Igal Rosenstein, Jan Lycke, Henrik Zetterberg, Aylin Yilmaz, Arvid Edén, Magnus Gisslén
Clinical chemistry and laboratory medicine - 2024 -
Tyro3 and Gas6 are associated with white matter and myelin integrity in multiple
sclerosis.
Igal Rosenstein, Lenka Nováková Nyrén, Hlin Kvartsberg, Anna Nordin, Sofia Rasch, Elzbieta Rembeza, Sofia Sandgren, Clas Malmeström, Stefanie Fruhwürth, Markus Axelsson, Kaj Blennow, Henrik Zetterberg, Jan Lycke
Journal of Neuroinflammation - 2024 -
BEAM or cyclophosphamide in autologous haematopoietic stem cell transplantation for relapsing-remitting multiple
sclerosis
Thomas Silfverberg, Christina Zjukovskaja, Yassine Noui, Kristina Carlson, Joachim Burman, Adjmal Nahimi, Ahlstrand Erik, Cherif Honar, Dreimane Arta, Sigrun Einarsdottir, Fagius Jan, Hägglund Hans, Iacobaeus Ellen, Lange Niclas, Lenhoff Stig, Ljungman Per, Jan Lycke, Mellergård Johan, Piehl Fredrik, Svenningsson Anders, Tolf Andreas
Bone Marrow Transplantation - 2024 -
Haematopoietic stem cell transplantation for treatment of relapsing-remitting multiple sclerosis in Sweden: an observational cohort
study
T. Silfverberg, C. Zjukovskaja, P. Ljungman, A. Nahimi, E. Ahlstrand, A. Dreimane, Sigrun Einarsdottir, J. Fagius, E. Iacobaeus, H. Hägglund, N. Lange, S. Lenhoff, Jan Lycke, J. Mellergård, F. Piehl, A. Svenningsson, A. Tolf, H. Cherif, K. Carlson, J. Burman
Journal of Neurology Neurosurgery and Psychiatry - 2024 -
Using serum neurofilament-light in clinical practice: Growing enthusiasm that may need
bridling
Jan Lycke, Robert J. Fox
MULTIPLE SCLEROSIS JOURNAL - 2024 -
Guidance for use of neurofilament light chain as a cerebrospinal fluid and blood biomarker in multiple sclerosis
management
Mark S. Freedman, Sharmilee Gnanapavan, Ronald A. Booth, Peter A. Calabresi, Michael Khalil, Jens Kuhle, Jan Lycke, Tomas Olsson
eBioMedicine - 2024 -
The effect of alemtuzumab on neurodegeneration in relapsing-remitting multiple sclerosis: A five-year prospective mono-center
study
Sofia Sandgren, Lenka Novakova, Anna Nordin, Hemin Sabir, Markus Axelsson, Clas Malmeström, Henrik Zetterberg, Jan Lycke
MULTIPLE SCLEROSIS AND RELATED DISORDERS - 2024 -
Neurofilament light chain as a diagnostic and prognostic biomarker in Guillain-Barré
syndrome
Brynhildur Hafsteinsdottir, Helen H. Farman, Nina Lagerstrom, Henrik Zetterberg, Oluf Andersen, Lenka Novakova, Bengt Nellgård, Hans Rosén, Clas Malmeström, Igal Rosenstein, Jan Lycke, Markus Axelsson
JOURNAL OF NEUROLOGY - 2024 -
Hypogammaglobulinaemia during rituximab treatment in multiple sclerosis: A Swedish cohort
study
Susanna Hallberg, Björn Evertsson, Ellen Lillvall, Malin Boremalm, Pierre de Flon, Yunzhang Wang, Jonatan Salzer, Jan Lycke, Katharina Fink, Thomas Frisell, Faiez Al Nimer, Anders Svenningsson
European Journal of Neurology - 2024 -
Association of Complement Factors With Disability Progression in Primary Progressive Multiple
Sclerosis
Jan D. Lunemann, Harald Hegen, Luisa Maria Villar, Konrad Rejdak, Augusto Sao-Aviles, Pere Carbonell-Mirabent, Jaume Sastre-Garriga, Neus Mongay-Ochoa, Klaus Berek, Sergio Martinez-Yelamos, Francisco Perez-Miralles, Ahmed Abdelhak, Franziska Bachhuber, Hayrettin Tumani, Jan Lycke, Igal Rosenstein, Roberto Alvarez-Lafuente, Tamara Castillo-Trivino, David Otaegui, Sara Llufriu, Yolanda Blanco, Antonio J. Sanchez Lopez, Juan Antonio Garcia Merino, Nicolas Fissolo, Lucia Gutierrez, Javier Villacieros-alvarez, Enric Monreal, Adrian Valls-Carbo, Heinz Wiendl, Xavier Montalban, Manuel Comabella
NEUROLOGY-NEUROIMMUNOLOGY & NEUROINFLAMMATION - 2024 -
Smouldering-Associated Worsening in Multiple Sclerosis: An International Consensus Statement on Definition, Biology, Clinical Implications, and Future
Directions
Antonio Scalfari, Anthony Traboulsee, Jiwon Oh, Laura Airas, Stefan Bittner, Massimiliano Calabrese, Jose Manuel Garcia Dominguez, Cristina Granziera, Benjamin Greenberg, Kerstin Hellwig, Zsolt Illes, Jan Lycke, Veronica Popescu, Francesca Bagnato, Gavin Giovannoni
ANNALS OF NEUROLOGY - 2024 -
COMBAT-MS: A Population-Based Observational Cohort Study Addressing the Benefit-Risk Balance of Multiple Sclerosis Therapies Compared with
Rituximab
Fredrik Piehl, Peter Alping, Suvi Virtanen, Simon Englund, Joachim Burman, Katharina Fink, Anna Fogdell-Hahn, Martin Gunnarsson, Jan Hillert, Annette Langer-Gould, Jan Lycke, Johan Mellergard, Petra Nilsson, Tomas Olsson, Jonatan Salzer, Anders Svenningsson, Thomas Frisell
ANNALS OF NEUROLOGY - 2024 -
Serum neurofilament light for detecting disease activity in individual patients in multiple sclerosis: A 48-week prospective single-center
study
Magnus Johnsson, Y. T. Stenberg, H. H. Farman, Kaj Blennow, Henrik Zetterberg, Clas Malmeström, Sofia Sandgren, Igal Rosenstein, Jan Lycke, Markus Axelsson, Lenka Novakova
MULTIPLE SCLEROSIS JOURNAL - 2024 -
Medically unexplained symptoms are common in women in tertiary neurological healthcare center: A survey cohort study of persons investigated for suspected multiple
sclerosis
Lenka Novakova, Anna Karin Hedstrom, Markus Axelsson, Anne Brandt, Lars Alfredsson, Tomas Olsson, Jan Lycke
BRAIN AND BEHAVIOR - 2024 -
Rituximab treatment in pediatric-onset multiple
sclerosis
Markus Breu, Fredrik Sandesjo, Ruxandra-Iulia Milos, Jan Svoboda, Jonatan Salzer, Lisa Schneider, Julian Benedikt Reichelt, Annikki Bertolini, Astrid Blaschek, Katharina Fink, Romana Hoeftberger, Jan Lycke, Kevin Rostasy, Rainer Seidl, Sandy Siegert, Ronny Wickstrom, Barbara Kornek
EUROPEAN JOURNAL OF NEUROLOGY - 2024 -
High temperature requirement A1 and macrophage migration inhibitory factor in the cerebrospinal fluid; a potential marker of conversion from relapsing-remitting to secondary progressive multiple
sclerosis
Simone Hjæresen, Eirikur Benedikz, Tobias Sejbaek, Markus Axelsson, Lenka Novakova, Mengliang Zhang, Jan Lycke, Zsolt Illes, Åsa Fex-Svenningsen
Journal of the Neurological Sciences - 2024 -
Serum biomarker levels predict disability progression in patients with primary progressive multiple
sclerosis
N. Fissolo, P. Benkert, J. Sastre-Garriga, N. Mongay-Ochoa, A. Vilaseca-Jolonch, S. Llufriu, Y. Blanco, H. Hegen, K. Berek, F. Perez-Miralles, K. Rejdak, L. M. Villar, E. Monreal, R. Alvarez-Lafuente, O. K. Soylu, A. Abdelhak, F. Bachhuber, H. Tumani, S. Martínez-Yélamos, A. J. Sánchez-López, A. García-Merino, L. Gutiérrez, T. Castillo-Trivino, Jan Lycke, Igal Rosenstein, R. Furlan, M. Filippi, N. Téllez, L. Ramió-Torrentà, J. D. Lünemann, H. Wiendl, S. Eichau, M. Khalil, J. Kuhle, X. Montalban, M. Comabella
Journal of Neurology Neurosurgery and Psychiatry - 2024 -
Trajectories of cognitive processing speed and physical disability over 11 years following initiation of a first multiple sclerosis disease-modulating
therapy
E. Longinetti, S. Englund, J. Burman, K. Fink, A. Fogdell-Hahn, M. Gunnarsson, J. Hillert, A. M. Langer-Gould, Jan Lycke, P. Nilsson, J. Salzer, A. Svenningsson, J. Mellergard, T. Olsson, F. Piehl, T. Frisell
Journal of Neurology, Neurosurgery and Psychiatry - 2024 -
Intrathecal kappa free light chain synthesis is associated with worse prognosis in relapsing-remitting multiple
sclerosis
Igal Rosenstein, Markus Axelsson, Lenka Novakova, Clas Malmeström, Kaj Blennow, Henrik Zetterberg, Jan Lycke
Journal of Neurology - 2023 -
A five-year observational prospective mono-center study of the efficacy of alemtuzumab in a real-world cohort of patients with multiple
sclerosis.
Sofia Sandgren, Lenka Nováková Nyrén, Anna Nordin, Markus Axelsson, Clas Malmeström, Henrik Zetterberg, Jan Lycke
Frontiers in neurology - 2023 -
The impact of hybrid immunity on immune responses after SARS-CoV-2 vaccination in persons with multiple sclerosis treated with disease-modifying
therapies
M. Rabenstein, O. G. Thomas, G. Carlin, M. Khademi, K. A. Högelin, Clas Malmeström, Markus Axelsson, Anne Brandt, G. Gafvelin, H. Grönlund, I. Kockum, F. Piehl, Jan Lycke, T. Olsson, T. Hessa
European Journal of Neurology - 2023 -
Predictors of patient-reported fatigue symptom severity in a nationwide multiple sclerosis
cohort
S. Englund, M. Kierkegaard, J. Burman, K. Fink, A. Fogdell-Hahn, M. Gunnarsson, J. Hillert, A. Langer-Gould, Jan Lycke, P. Nilsson, J. Salzer, A. Svenningsson, J. Mellergard, T. Olsson, E. Longinetti, T. Frisell, F. Piehl
Multiple Sclerosis and Related Disorders - 2023 -
CYBA allelic variants are associated with severity and recovery in Guillain-Barré
syndrome
Andreas Törnell, Nina Lagerström, Natalia Mossberg, Roberta Kiffin, Helen H. Farman, Jan Lycke, Oluf Andersen, Markus Axelsson, Kristoffer Hellstrand, Anna Martner
Journal of the peripheral nervous system - 2023 -
Cerebrospinal fluid sulfatide isoforms lack diagnostic utility in separating progressive from relapsing-remitting multiple
sclerosis.
Lenka Novakova, Marcus Henricsson, Elias Björnson, Markus Axelsson, Jan Borén, Igal Rosenstein, Jan Lycke, Susanna Cardell, Maria K. Blomqvist
Multiple sclerosis and related disorders - 2023 -
Comparative effectiveness of natalizumab on cognition in multiple sclerosis: A cohort
study
A. Manouchehrinia, H. Larsson, M. E. Karim, Jan Lycke, T. Olsson, I. Kockum
Multiple Sclerosis Journal - 2023 -
Does initial high efficacy therapy in multiple sclerosis surpass escalation treatment strategy? A comparison of patients with relapsing-remitting multiple sclerosis in the Czech and Swedish national multiple sclerosis
registries
T. Hrnciarova, J. Drahota, T. Spelman, J. Hillert, Jan Lycke, E. K. Havrdova, E. Recmanova, J. Adamkova, J. Mares, J. Libertinova, Z. Pavelek, P. Hradilek, R. Ampapa, I. Stetkarova, M. Peterka, A. Martinkova, P. Stourac, M. Grunermelova, M. Vachova, M. Dufek, D. Horakova
Multiple Sclerosis and Related Disorders - 2023 -
The role of autoimmune antibodies to predict secondary autoimmunity in patients with relapsing-remitting multiple sclerosis treated with alemtuzumab: A nationwide prospective
survey
Sofia Sandgren, Lenka Novakova, Markus Axelsson, Firoozeh Amirbeagi, I. Kockum, T. Olsson, Clas Malmeström, Jan Lycke
Frontiers in Neurology - 2023 -
High levels of kappa free light chain synthesis predict cognitive decline in relapsing-remitting multiple
sclerosis
Igal Rosenstein, Markus Axelsson, Lenka Novakova, S. Rasch, Kaj Blennow, Henrik Zetterberg, Jan Lycke
FRONTIERS IN IMMUNOLOGY - 2023 -
Teriflunomide Concentrations in Cerebrospinal Fluid and Plasma in Patients with Multiple Sclerosis: A Pharmacokinetic
Study
Jan Lycke, Helen H. Farman, Anna Nordin
CNS Drugs - 2023 -
MIF in the cerebrospinal fluid is decreased during relapsing-remitting while increased in secondary progressive multiple
sclerosis
S. Hjaeresen, T. Sejbaek, Markus Axelsson, S. K. Mortensen, H. Vinslov-Jensen, G. Pihl-Jensen, Lenka Novakova, C. B. Pedersen, B. Halle, F. R. Poulsen, M. L. Zhang, E. Benedikz, J. L. Frederiksen, Jan Lycke, Z. Illes, A. Fex-Svenningsen
Journal of the Neurological Sciences - 2022 -
Safety and efficacy of rituximab versus dimethyl fumarate in patients with relapsing-remitting multiple sclerosis or clinically isolated syndrome in Sweden: a rater-blinded, phase 3, randomised controlled
trial
A. Svenningsson, T. Frisell, J. Burman, J. Salzer, K. Fink, S. Hallberg, J. Hambraeus, Markus Axelsson, F. Al Nimer, P. Sundstrom, M. Gunnarsson, R. Johansson, J. Mellergard, Igal Rosenstein, A. Ayad, I. Sjoblom, A. Risedal, P. de Flon, Eric Gilland, J. Lindeberg, F. Shawket, F. Piehl, Jan Lycke
Lancet Neurology - 2022 -
Effectiveness of first generation disease-modifying therapy to prevent conversion to secondary progressive multiple
sclerosis
Helen Tedeholm, Fredrik Piehl, Jan Lycke, Jenny Link, Leszek Stawiarz, Joachim Burman, P. de Flon, Katarina Fink, Martin Gunnarsson, Johan Mellergård, P. Nilsson, Peter Sundström, Anders Svenningsson, Helena Johansson, Oluf Andersen
Multiple Sclerosis and Related Disorders - 2022 -
Long-term treatment with anti-CD20 monoclonal antibodies is untenable because of risk:
Commentary
Jan Lycke, A. Svenningsson
Multiple Sclerosis Journal - 2022 -
Smouldering multiple sclerosis: the ‘real
MS’
G. Giovannoni, V. Popescu, J. Wuerfel, K. Hellwig, E. Iacobeus, M. B. Jensen, J. M. García-Domínguez, L. Sousa, N. De Rossi, R. Hupperts, G. Fenu, B. Bodini, H. M. Kuusisto, B. Stankoff, Jan Lycke, L. Airas, C. Granziera, A. Scalfari
Therapeutic Advances in Neurological Disorders - 2022 -
Increased intrathecal neurofilament light and immunoglobulin M predict severe disability in relapsing-remitting multiple
sclerosis
Igal Rosenstein, S. Rasch, Markus Axelsson, Lenka Novakova, Kaj Blennow, Henrik Zetterberg, Jan Lycke
Frontiers in Immunology - 2022 -
COVID-19 clinical outcomes and DMT of MS patients and population-based
controls
E. Longinetti, H. Bower, K. A. McKay, S. Englund, J. Burman, K. Fink, A. Fogdell-Hahn, M. Gunnarsson, J. Hillert, A. Langer-Gould, Jan Lycke, P. Nilsson, J. Salzer, A. Svenningsson, J. Mellergard, T. Olsson, F. Piehl, T. Frisell
Annals of Clinical and Translational Neurology - 2022 -
No increase of serum neurofilament light in relapsing-remitting multiple sclerosis patients switching from standard to extended-interval dosing of
natalizumab
Magnus Johnsson, Helen H. Farman, Kaj Blennow, Henrik Zetterberg, Clas Malmeström, Markus Axelsson, Jan Lycke
Multiple Sclerosis Journal - 2022 -
SARS-COV-2 a trigger of myelin oligodendrocyte glycoprotein-associated
disorder
Magnus Johnsson, Fredrik Asztely, S. Hejnebo, Markus Axelsson, Clas Malmeström, T. Olausson, Jan Lycke
Annals of Clinical and Translational Neurology - 2022 -
Exploring CSF neurofilament light as a biomarker for MS in clinical practice; a retrospective registry-based
study
Igal Rosenstein, Markus Axelsson, Lenka Novakova, Kaj Blennow, Henrik Zetterberg, Jan Lycke
Multiple Sclerosis Journal - 2022 -
Efficacy of prolonged-release fampridine versus placebo on walking ability, dynamic and static balance, physical impact of multiple sclerosis, and quality of life: an integrated analysis of MOBILE and
ENHANCE
R. Hupperts, C. Gasperini, Jan Lycke, T. Ziemssen, P. Feys, S. Xiao, C. Acosta, T. Koster, J. Hobart
Therapeutic Advances in Neurological Disorders - 2022 -
Safety of Alemtuzumab and Autologous Hematopoietic Stem Cell Transplantation Compared to Noninduction Therapies for Multiple
Sclerosis
Peter Alping, Joachim Burman, Jan Lycke, Frisell Thomas, Fredrik Piehl
Neurology - 2021 -
Modeling the cost-effectiveness of prolonged-release fampridine for the treatment of walking impairment in patients with multiple sclerosis in
Sweden
C. Acosta, M. Gianinazzi, T. Dort, N. Armstrong, S. Ryder, T. Lundqvist, M. Ekelund, Jan Lycke
Journal of Medical Economics - 2021
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