Nicholas Ashton
-
Association of Chronic Kidney Disease With Plasma NfL and Other Biomarkers of Neurodegeneration: The H70 Birth Cohort Study in
Gothenburg.
Anna Dittrich, Nicholas J. Ashton, Henrik Zetterberg, Kaj Blennow, Anna Zettergren, Joel Simrén, Tobias Skillbäck, Sara Shams, Alejandra Machado, Eric Westman, Michael Schöll, Ingmar Skoog, Silke Kern
Neurology - 2023 -
Prevalence and Clinical Implications of a β-Amyloid-Negative, Tau-Positive Cerebrospinal Fluid Biomarker Profile in Alzheimer
Disease.
Pontus Erickson, Joel Simrén, Wagner S. Brum, Gilda E Ennis, Gwendlyn Kollmorgen, Ivonne Suridjan, Rebecca Langhough, Erin M Jonaitis, Carol A Van Hulle, Tobey J Betthauser, Cynthia M Carlsson, Sanjay Asthana, Nicholas J. Ashton, Sterling C Johnson, Leslie M Shaw, Kaj Blennow, Ulf Andreasson, Barbara B Bendlin, Henrik Zetterberg
JAMA neurology - 2023 -
APOEε4 associates with microglial activation independently of Aβ plaques and tau
tangles
J. P. Ferrari-Souza, F. Z. Lussier, D. T. Leffa, J. Therriault, C. Tissot, B. Bellaver, P. C. L. Ferreira, M. Malpetti, Y. T. Wang, G. Povala, Andréa Lessa Benedet, Nicholas J. Ashton, M. Chamoun, S. Servaes, G. Bezgin, M. S. Kang, J. Stevenson, N. Rahmouni, V. Pallen, N. M. Poltronetti, J. T. O'Brlen, J. B. Rowe, A. D. Cohen, O. L. Lopez, D. L. Tudorascu, Thomas Karikari, W. E. Klunk, V. L. Villemagne, J. P. Soucy, S. Gauthier, D. O. Souza, Henrik Zetterberg, Kaj Blennow, E. R. Zimmer, P. Rosa-Neto, T. A. Pascoal
Science Advances - 2023 -
Longitudinal changes in Alzheimer's-related plasma biomarkers and brain
amyloid
M. Bilgel, Y. An, K. A. Walker, A. R. Moghekar, Nicholas J. Ashton, Przemyslaw R. Kac, Thomas Karikari, Kaj Blennow, Henrik Zetterberg, B. M. Jedynak, M. Thambisetty, L. Ferrucci, S. M. Resnick
Alzheimers & Dementia - 2023 -
Plasma and CSF biomarkers in a memory clinic: Head-to-head comparison of phosphorylated tau
immunoassays
Nicholas J. Ashton, A. Puig-Pijoan, M. Mila-Aloma, A. Fernandez-Lebrero, G. Garcia-Escobar, Fernando Gonzalez-Ortiz, Przemyslaw R. Kac, Wagner S. Brum, Andréa Lessa Benedet, Juan Lantero Rodriguez, T. A. Day, J. Vanbrabant, E. Stoops, E. Vanmechelen, G. Triana-Baltzer, S. Moughadam, H. Kolb, P. Ortiz-Romero, Thomas Karikari, C. Minguillon, J. J. H. Sanchez, I. Navalpotro-Gomez, O. Grau-Rivera, R. M. Manero, V. Puente-Periz, R. de la Torre, J. Roquer, J. L. Dage, Henrik Zetterberg, Kaj Blennow, M. Suarez-Calvet
Alzheimers & Dementia - 2023 -
Longitudinal blood biomarker trajectories in preclinical Alzheimer's
disease
Y. Yakoub, Nicholas J. Ashton, C. Strikwerda-Brown, Laia Montoliu-Gaya, Thomas Karikari, Przemyslaw R. Kac, Fernando Gonzalez-Ortiz, J. Gallego-Rudolf, P. F. Meyer, F. St-Onge, Michael Schöll, J. P. Soucy, J. C. S. Breitner, Henrik Zetterberg, Kaj Blennow, J. Poirier, S. Villeneuve
Alzheimers & Dementia - 2023 -
Levels of Alzheimer's disease blood biomarkers are altered after food intake-A pilot intervention study in healthy
adults
Hanna Huber, Nicholas J. Ashton, A. Schieren, Laia Montoliu-Gaya, Guglielmo Di Molfetta, Wagner S. Brum, Juan Lantero Rodriguez, Lana Grötschel, B. Stoffel-Wagner, M. Coenen, L. Weinhold, M. Schmid, Kaj Blennow, P. Stehle, Henrik Zetterberg, M. C. Simon
Alzheimers & Dementia - 2023 -
Blood-brain barrier integrity impacts the use of plasma amyloid-beta as a proxy of brain amyloid-beta
pathology
B. Bellaver, A. Puig-Pijoan, J. P. Ferrari-Souza, D. T. Leffa, F. Z. Lussier, P. C. L. Ferreira, C. Tissot, G. Povala, J. Therriault, Andréa Lessa Benedet, Nicholas J. Ashton, S. Servaes, M. Chamoun, J. Stevenson, N. Rahmouni, M. Vermeiren, A. C. Macedo, A. Fernandez-Lebrero, G. Garcia-Escobar, I. Navalpotro-Gomez, O. Lopez, D. L. Tudorascu, A. Cohen, V. L. Villemagne, W. E. Klunk, S. Gauthier, E. R. Zimmer, Thomas Karikari, Kaj Blennow, Henrik Zetterberg, M. Suarez-Calvet, P. Rosa-Neto, T. A. Pascoal
Alzheimers & Dementia - 2023 -
Plasma and CSF concentrations of N-terminal tau fragments associate with in vivo neurofibrillary tangle
burden
Juan Lantero Rodriguez, C. Tissot, Anniina Snellman, S. Servaes, Andréa Lessa Benedet, N. Rahmouni, Laia Montoliu-Gaya, J. Therriault, Wagner S. Brum, J. Stevenson, F. Z. Lussier, G. Bezgin, A. C. Macedo, M. Chamoun, S. S. Mathotaarachi, T. A. Pascoal, Nicholas J. Ashton, Henrik Zetterberg, P. R. Neto, Kaj Blennow
Alzheimers & Dementia - 2023 -
Plasma and cerebrospinal fluid glial fibrillary acidic protein levels in adults with Down syndrome: a longitudinal cohort
study
Laia Montoliu-Gaya, D. Alcolea, Nicholas J. Ashton, J. Pegueroles, J. Levin, B. Bosch, Juan Lantero Rodriguez, M. Carmona-Iragui, O. Wagemann, M. Balasa, Przemyslaw R. Kac, I. Barroeta, A. Llado, Wagner S. Brum, L. Videla, Fernando Gonzalez-Ortiz, B. Benejam, J. J. A. Martinez, Thomas Karikari, G. Nubling, A. Bejanin, Andréa Lessa Benedet, R. Blesa, A. Lleo, Kaj Blennow, R. Sanchez-Valle, Henrik Zetterberg, J. Fortea
eBioMedicine - 2023 -
Blood beta-synuclein is related to amyloid PET positivity in memory clinic
patients
P. Oeckl, M. Bluma, M. Bucci, S. Halbgebauer, K. Chiotis, A. Sandebring-Matton, Nicholas J. Ashton, Guglielmo Di Molfetta, Lana Grötschel, M. Kivipelto, Kaj Blennow, Henrik Zetterberg, I. Savitcheva, A. Nordberg, M. Otto
Alzheimers & Dementia - 2023 -
Preanalytical stability of plasma biomarkers for Alzheimer's disease
pathology
A. L. Sunde, I. V. Alsnes, D. Aarsland, Nicholas J. Ashton, D. A. Tovar-Rios, Giovanni de Santis, Kaj Blennow, Henrik Zetterberg, S. R. Kjosavik
Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring - 2023 -
Mass spectrometric simultaneous quantification of tau species in plasma shows differential associations with amyloid and tau
pathologies
L. Montoliu-Gaya, Andréa Lessa Benedet, C. Tissot, A. Vrillon, Nicholas J. Ashton, Wagner S. Brum, Juan Lantero Rodriguez, J. Stevenson, Johanna Nilsson, Mathias Sauer, N. Rahmouni, Gunnar Brinkmalm, F. Z. Lussier, T. A. Pascoal, Ingmar Skoog, Silke Kern, Henrik Zetterberg, C. Paquet, Johan Gobom, P. Rosa-Neto, Kaj Blennow
Nature Aging - 2023 -
Cerebrospinal fluid and positron-emission tomography biomarkers for noradrenergic dysfunction in neurodegenerative diseases: a systematic review and
meta-analysis
E. Lancini, L. Haag, F. Bartl, M. Ruhling, Nicholas J. Ashton, Henrik Zetterberg, E. Duzel, D. Hammerer, M. J. Betts
Brain Communications - 2023 -
Brain atrophy and white matter hyperintensities are independently associated with plasma neurofilament light chain in an Asian cohort of cognitively impaired patients with concomitant cerebral small vessel
disease
J. R. Chong, S. Hilal, Nicholas J. Ashton, Thomas Karikari, A. Reilhac, H. Vrooman, Michael Schöll, Henrik Zetterberg, Kaj Blennow, C. P. Chen, M. K. P. Lai
Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring - 2023 -
Alzheimer Disease Blood Biomarkers in Patients With Out-of-Hospital Cardiac
Arrest
Nicholas J. Ashton, M. Moseby-Knappe, Andréa Lessa Benedet, Lana Grötschel, Juan Lantero Rodriguez, Thomas Karikari, C. Hassager, M. P. Wise, P. Stammet, J. Kjaergaard, H. Friberg, N. Nielsen, T. Cronberg, Henrik Zetterberg, Kaj Blennow
Jama Neurology - 2023 -
Head-to-head comparison of 10 plasma phospho-tau assays in prodromal Alzheimer's
disease.
Shorena Janelidze, Divya Bali, Nicholas J. Ashton, Nicolas R Barthélemy, Jeroen Vanbrabant, Erik Stoops, Eugeen Vanmechelen, Yingxin He, Anna Orduña Dolado, Gallen Triana-Baltzer, Michael J Pontecorvo, Henrik Zetterberg, Hartmuth Kolb, Manu Vandijck, Kaj Blennow, Randall J Bateman, Oskar Hansson
Brain : a journal of neurology - 2023 -
Equivalence of plasma p-tau217 with cerebrospinal fluid in the diagnosis of Alzheimer's
disease
J. Therriault, S. Servaes, C. Tissot, N. Rahmouni, Nicholas J. Ashton, Andréa Lessa Benedet, Thomas Karikari, A. C. Macedo, F. Z. Lussier, J. Stevenson, Y. T. Wang, J. Fernandez-Arias, A. Stevenson, K. Q. Socualaya, A. Haeger, T. Nazneen, Aumont, Aumont,, A. Hosseini, S. Rej, P. Vitali, G. Triana-Baltzer, H. C. Kolb, J. P. Soucy, T. A. Pascoal, S. Gauthier, Henrik Zetterberg, Kaj Blennow, P. Rosa-Neto
Alzheimers & Dementia - 2023 -
Ultra-high field imaging, plasma markers and autopsy data uncover a specific rostral locus coeruleus vulnerability to hyperphosphorylated
tau
M. Van Egroo, J. M. Riphagen, Nicholas J. Ashton, S. Janelidze, R. A. Sperling, K. A. Johnson, H. S. Yang, D. A. Bennett, Kaj Blennow, O. Hansson, Henrik Zetterberg, H. I. L. Jacobs
Molecular Psychiatry - 2023 -
APOE epsilon 4 gene dose effect on imaging and blood biomarkers of neuroinflammation and beta-amyloid in cognitively unimpaired
elderly
Anniina Snellman, L. L. Ekblad, J. Tuisku, M. Koivumaki, Nicholas J. Ashton, Juan Lantero Rodriguez, Thomas Karikari, S. Helin, M. Bucci, E. Loyttyniemi, R. Parkkola, M. Karrasch, Michael Schöll, Henrik Zetterberg, Kaj Blennow, J. O. Rinne
Alzheimers Research & Therapy - 2023 -
Prediction of Longitudinal Cognitive Decline in Preclinical Alzheimer Disease Using Plasma
Biomarkers
N. Mattsson-Carlgren, G. Salvado, Nicholas J. Ashton, P. Tideman, E. Stomrud, Henrik Zetterberg, R. Ossenkoppele, T. J. Betthauser, K. A. Cody, E. M. Jonaitis, R. Langhough, S. Palmqvist, Kaj Blennow, S. Janelidze, S. C. Johnson, O. Hansson
Jama Neurology - 2023 -
Exploring semantic verbal fluency patterns and their relationship to age and Alzheimer's disease in adults with Down
syndrome.
Farah Mgaieth, R Asaad Baksh, Carla M Startin, Sarah Hamburg, Rosalyn Hithersay, Sarah Pape, Henrik Zetterberg, Nicholas J. Ashton, Miren Tamayo-Elizalde, Fedal Saini, Mina Idris, The LonDownS Consortium, Andre Strydom
Alzheimer's & dementia : the journal of the Alzheimer's Association - 2023 -
Hippocampal GFAP-positive astrocyte responses to amyloid and tau
pathologies.
Marco Antônio De Bastiani, Bruna Bellaver, Wagner S. Brum, Debora G Souza, Pamela C L Ferreira, Andreia S Rocha, Guilherme Povala, João Pedro Ferrari-Souza, Andréa Lessa Benedet, Nicholas J. Ashton, Thomas Karikari, Henrik Zetterberg, Kaj Blennow, Pedro Rosa-Neto, Tharick A Pascoal, Eduardo R Zimmer
Brain, behavior, and immunity - 2023 -
Plasma neurofilament light is a predictor of neurological outcome 12 h after cardiac
arrest
H. Levin, A. Lybeck, A. Frigyesi, I. Arctaedius, B. Thorgeirsdottir, M. Annborn, M. Moseby-Knappe, N. Nielsen, T. Cronberg, Nicholas J. Ashton, Henrik Zetterberg, Kaj Blennow, H. Friberg, N. Mattsson-Carlgren
Critical Care - 2023 -
Transient Changes in the Plasma of Astrocytic and Neuronal Injury Biomarkers in COVID-19 Patients without Neurological
Syndromes
M. P. Lennol, Nicholas J. Ashton, O. Moreno-Perez, M. S. Garcia-Ayllon, J. M. Ramos-Rincon, M. Andres, J. M. Leon-Ramirez, V. Boix, J. Gil, Kaj Blennow, E. Merino, Henrik Zetterberg, J. Saez-Valero
International Journal of Molecular Sciences - 2023 -
Clinical performance and head-to-head comparison of CSF p-tau235 with p-tau181, p-tau217 and p-tau231 in two memory clinic
cohorts
Juan Lantero Rodriguez, A. Vrillon, A. Fernandez-Lebrero, P. Ortiz-Romero, Anniina Snellman, Laia Montoliu-Gaya, Wagner S. Brum, E. Cognat, J. Dumurgier, A. Puig-Pijoan, I. Navalpotro-Gomez, G. Garcia-Escobar, Thomas Karikari, E. Vanmechelen, Nicholas J. Ashton, Henrik Zetterberg, M. Suarez-Calvet, C. Paquet, Kaj Blennow
Alzheimers Research & Therapy - 2023 -
Specific associations between plasma biomarkers and postmortem amyloid plaque and tau tangle
loads
G. Salvado, R. Ossenkoppele, Nicholas J. Ashton, T. G. Beach, G. E. Serrano, E. M. Reiman, Henrik Zetterberg, N. Mattsson-Carlgren, S. Janelidze, Kaj Blennow, O. Hansson
Embo Molecular Medicine - 2023 -
Blood-brain barrier opening of the default mode network in Alzheimer's disease with magnetic resonance-guided focused
ultrasound
Y. Meng, M. Goubran, J. S. Rabin, M. McSweeney, J. Ottoy, C. B. Pople, Y. X. Huang, A. Storace, M. Ozzoude, A. Bethune, B. Lam, W. Swardfager, C. Heyn, A. Abrahao, B. Davidson, C. Hamani, I. Aubert, Henrik Zetterberg, Nicholas J. Ashton, Thomas Karikari, Kaj Blennow, S. E. Black, K. Hynynen, N. Lipsman
Brain - 2023 -
Association of CSF GAP-43 With the Rate of Cognitive Decline and Progression to Dementia in Amyloid-Positive
Individuals.
Annika Öhrfelt, Andréa Lessa Benedet, Nicholas J. Ashton, Hlin Kvartsberg, Manu Vandijck, Michael W Weiner, John Q Trojanowski, Leslie M Shaw, Henrik Zetterberg, Kaj Blennow
Neurology - 2023 -
Plasma GFAP in presymptomatic and symptomatic familial Alzheimer's disease: a longitudinal cohort
study.
Antoinette O'Connor, Emily Abel, Andréa Lessa Benedet, Teresa Poole, Nicholas J. Ashton, Philip Simon John Weston, Amanda J Heslegrave, Natalie Ryan, Suzie Barker, James M Polke, Kaj Blennow, Henrik Zetterberg, Nick C Fox
Journal of neurology, neurosurgery, and psychiatry - 2023 -
Brain-derived tau: a novel blood-based biomarker for Alzheimer's disease-type
neurodegeneration.
Fernando Gonzalez-Ortiz, Michael Turton, Przemyslaw R. Kac, Denis Smirnov, Enrico Premi, Roberta Ghidoni, Luisa Benussi, Valentina Cantoni, Claudia Saraceno, Jasmine Rivolta, Nicholas J. Ashton, Barbara Borroni, Douglas Galasko, Peter Harrison, Henrik Zetterberg, Kaj Blennow, Thomas Karikari
Brain : a journal of neurology - 2022 -
Association of Phosphorylated Tau Biomarkers With Amyloid Positron Emission Tomography vs Tau Positron Emission
Tomography.
Joseph Therriault, Marie Vermeiren, Stijn Servaes, Cécile Tissot, Nicholas J. Ashton, Andréa Lessa Benedet, Thomas Karikari, Juan Lantero Rodriguez, Wagner S. Brum, Firoza Z Lussier, Gleb Bezgin, Jenna Stevenson, Nesrine Rahmouni, Peter Kunach, Yi-Ting Wang, Jaime Fernandez-Arias, Kely Quispialaya Socualaya, Arthur C Macedo, João Pedro Ferrari-Souza, Pâmela C L Ferreira, Bruna Bellaver, Douglas T Leffa, Eduardo R Zimmer, Paolo Vitali, Jean-Paul Soucy, Gallen Triana-Baltzer, Hartmuth C Kolb, Tharick A Pascoal, Paramita Saha-Chaudhuri, Serge Gauthier, Henrik Zetterberg, Kaj Blennow, Pedro Rosa-Neto
JAMA neurology - 2022 -
Publisher Correction: Plasma p-tau231 and p-tau217 as state markers of amyloid-β pathology in preclinical Alzheimer's
disease.
Marta Milà-Alomà, Nicholas J. Ashton, Mahnaz Shekari, Gemma Salvadó, Paula Ortiz-Romero, Laia Montoliu-Gaya, Andréa Lessa Benedet, Thomas Karikari, Juan Lantero Rodriguez, Eugeen Vanmechelen, Theresa A Day, Armand González-Escalante, Gonzalo Sánchez-Benavides, Carolina Minguillon, Karine Fauria, José Luis Molinuevo, Jeffrey L Dage, Henrik Zetterberg, Juan Domingo Gispert, Marc Suárez-Calvet, Kaj Blennow
Nature medicine - 2022 -
Antibody-free measurement of cerebrospinal fluid tau phosphorylation across the Alzheimer's disease
continuum.
Johan Gobom, Andréa Lessa Benedet, Niklas Mattsson-Carlgren, Laia Montoliu-Gaya, Nina Schultz, Nicholas J. Ashton, Shorena Janelidze, Stijn Servaes, Mathias Sauer, Tharick A Pascoal, Thomas Karikari, Juan Lantero Rodriguez, Gunnar Brinkmalm, Henrik Zetterberg, Oskar Hansson, Pedro Rosa-Neto, Kaj Blennow
Molecular neurodegeneration - 2022 -
CSF biomarkers and plasma p-tau181 as predictors of longitudinal tau accumulation: Implications for clinical trial
design
Alexis Moscoso Rial, Thomas Karikari, Michel J. Grothe, Nicholas J. Ashton, Juan Lantero Rodriguez, Anniina Snellman, Henrik Zetterberg, Kaj Blennow, Michael Schöll
Alzheimer's and Dementia - 2022 -
Amyloid processing in COVID-19-associated neurological
syndromes
O. J. Ziff, Nicholas J. Ashton, P. R. Mehta, R. Brown, D. Athauda, J. Heaney, A. J. Heslegrave, Andréa Lessa Benedet, Kaj Blennow, A. M. Checkley, C. F. Houlihan, S. Gauthier, P. Rosa-Neto, N. C. Fox, J. M. Schott, Henrik Zetterberg, L. A. Benjamin, R. W. Paterson
Journal of Neurochemistry - 2022 -
CSF tau368/total-tau ratio reflects cognitive performance and neocortical tau better compared to p-tau181 and p-tau217 in cognitively impaired
individuals.
Joel Simrén, Wagner S. Brum, Nicholas J. Ashton, Andréa Lessa Benedet, Thomas Karikari, Hlin Kvartsberg, Emma Sjons, Firoza Z Lussier, Mira Chamoun, Jenna Stevenson, Robert Hopewell, Vanessa Pallen, Keqiang Ye, Tharick A Pascoal, Henrik Zetterberg, Pedro Rosa-Neto, Kaj Blennow
Alzheimer's research & therapy - 2022 -
Plasma biomarkers for Alzheimer's Disease in relation to neuropathology and cognitive
change
D. S. Smirnov, Nicholas J. Ashton, Kaj Blennow, Henrik Zetterberg, Joel Simrén, Juan Lantero Rodriguez, Thomas Karikari, A. Hiniker, R. A. Rissman, D. P. Salmon, D. Galasko
Acta Neuropathologica - 2022 -
Plasma p-tau181 shows stronger network association to Alzheimer's disease dementia than neurofilament light and total
tau.
Brandon Frank, Madeline Ally, Bailee Brekke, Henrik Zetterberg, Kaj Blennow, Michael A Sugarman, Nicholas J. Ashton, Thomas Karikari, Yorghos Tripodis, Brett Martin, Joseph N Palmisano, Eric G Steinberg, Irene Simkina, Katherine W Turk, Andrew E Budson, Maureen K O'Connor, Rhoda Au, Lee E Goldstein, Gyungah R Jun, Neil W Kowall, Thor D Stein, Ann C McKee, Ronald Killiany, Wei Qiao Qiu, Robert A Stern, Jesse Mez, Michael L Alosco
Alzheimer's & dementia : the journal of the Alzheimer's Association - 2022 -
Diagnostic and prognostic plasma biomarkers for preclinical Alzheimer's
disease.
Pratishtha Chatterjee, Steve Pedrini, Nicholas J. Ashton, Michelle Tegg, Kathryn Goozee, Abhay K Singh, Thomas Karikari, Joel Simrén, Eugeen Vanmechelen, Nicola J Armstrong, Eugene Hone, Prita R Asih, Kevin Taddei, Vincent Doré, Victor L Villemagne, Hamid R Sohrabi, Henrik Zetterberg, Colin L Masters, Kaj Blennow, Ralph N Martins
Alzheimer's & dementia : the journal of the Alzheimer's Association - 2022 -
Apolipoprotein B is a novel marker for early tau pathology in Alzheimer's
disease
C. Picard, N. Nilsson, A. Labonte, D. Auld, P. Rosa-Neto, Nicholas J. Ashton, Henrik Zetterberg, Kaj Blennow, J. C. B. Breitner, S. Villeneuve, J. Poirier
Alzheimers & Dementia - 2022 -
Differences between blood and cerebrospinal fluid glial fibrillary Acidic protein levels: The effect of sample
stability
Joel Simrén, Haley Weninger, Wagner S. Brum, Shilla Khalil, Andréa Lessa Benedet, Kaj Blennow, Henrik Zetterberg, Nicholas J. Ashton
Alzheimers & Dementia - 2022 -
Differential roles of Aβ42/40, p-tau231 and p-tau217 for Alzheimer's trial selection and disease
monitoring.
Nicholas J. Ashton, Shorena Janelidze, Niklas Mattsson-Carlgren, Alexa Pichet Binette, Olof Strandberg, Wagner S. Brum, Thomas Karikari, Fernándo González-Ortiz, Guglielmo Di Molfetta, Francisco J Meda, Erin M Jonaitis, Rebecca Langhough Koscik, Karly Cody, Tobey J Betthauser, Yan Li, Eugeen Vanmechelen, Sebastian Palmqvist, Erik Stomrud, Randall J Bateman, Henrik Zetterberg, Sterling C Johnson, Kaj Blennow, Oskar Hansson
Nature medicine - 2022 -
Editorial: Blood Biomarkers of Neurodegenerative
Diseases.
Thomas Karikari, Nicholas J. Ashton, Henrik Zetterberg, Kaj Blennow
Frontiers in molecular neuroscience - 2022 -
Reactive astrogliosis is associated with higher cerebral glucose consumption in the early Alzheimer's
continuum
G. Salvado, M. Mila-Aloma, M. Shekari, Nicholas J. Ashton, G. Operto, C. Falcon, R. Cacciaglia, C. Minguillon, K. Fauria, A. Ninerola-Baizan, A. Perissinotti, Andréa Lessa Benedet, G. Kollmorgen, I. Suridjan, N. Wild, J. L. Molinuevo, Henrik Zetterberg, Kaj Blennow, M. Suarez-Calvet, J. D. Gispert
European Journal of Nuclear Medicine and Molecular Imaging - 2022 -
Evaluation of in vivo staging of amyloid deposition in cognitively unimpaired elderly aged
78-94
M. M. Michalowska, K. Herholz, R. Hinz, C. Amadi, L. McInnes, J. M. Anton-Rodriguez, Thomas Karikari, Kaj Blennow, Henrik Zetterberg, Nicholas J. Ashton, N. Pendleton, S. F. Carter
Molecular Psychiatry - 2022 -
Brain injury in COVID-19 is associated with dysregulated innate and adaptive immune
responses
E. J. Needham, A. L. Ren, R. J. Digby, E. J. Norton, S. Ebrahimi, J. G. Outtrim, D. A. Chatfield, A. E. Manktelow, M. M. Leibowitz, V. F. J. Newcombe, R. Doffinger, G. Barcenas-Morales, C. Fonseca, M. J. Taussig, R. M. Burnstein, R. J. Samanta, C. Dunai, N. Sithole, Nicholas J. Ashton, Henrik Zetterberg, Magnus Gisslén, Arvid Edén, Emelie Marklund, P. J. M. Openshaw, J. Dunning, M. J. Griffiths, J. Cavanagh, G. Breen, S. R. Irani, A. Elmer, N. Kingston, C. Summers, J. R. Bradley, L. S. Taams, B. D. Michael, E. T. Bullmore, K. G. C. Smith, P. A. Lyons, A. J. Coles, D. K. Menon
Brain - 2022 -
Cerebrospinal fluid p-tau231 as an early indicator of emerging pathology in Alzheimer's
disease
Nicholas J. Ashton, Andréa Lessa Benedet, Tharick A. Pascoal, Thomas Karikari, Juan Lantero Rodriguez, Wagner S. Brum, S. Mathotaarachchi, J. Therriault, M. Savard, M. Chamoun, E. Stoops, C. Francois, E. Vanmechelen, S. Gauthier, E. R. Zimmer, Henrik Zetterberg, Kaj Blennow, P. Rosa-Neto
Ebiomedicine - 2022 -
Plasma p-tau231, p-tau181, PET Biomarkers, and Cognitive Change in Older
Adults.
Pierre-François Meyer, Nicholas J. Ashton, Thomas Karikari, Cherie Strikwerda-Brown, Theresa Köbe, Julie Gonneaud, Alexa Pichet Binette, Hazal Ozlen, Yara Yakoub, Joel Simrén, Josef Pannee, Juan Lantero Rodriguez, Anne Labonté, Suzanne L Baker, Michael Schöll, Eugeen Vanmechelen, John C S Breitner, Henrik Zetterberg, Kaj Blennow, Judes Poirier, Sylvia Villeneuve
Annals of neurology - 2022 -
Classification accuracy of blood-based and neurophysiological markers in the differential diagnosis of Alzheimer's disease and frontotemporal lobar
degeneration
A. Benussi, V. Cantoni, J. Rivolta, S. Archetti, A. Micheli, Nicholas J. Ashton, Henrik Zetterberg, Kaj Blennow, B. Borroni
Alzheimers Research & Therapy - 2022 -
Biomarker modeling of Alzheimer’s disease using PET-based Braak
staging
J. Therriault, T. A. Pascoal, F. Z. Lussier, C. Tissot, M. Chamoun, G. Bezgin, S. Servaes, Andréa Lessa Benedet, Nicholas J. Ashton, Thomas Karikari, Juan Lantero Rodriguez, P. Kunach, Y. T. Wang, J. Fernandez-Arias, G. Massarweh, P. Vitali, J. P. Soucy, P. Saha-Chaudhuri, Kaj Blennow, Henrik Zetterberg, S. Gauthier, P. Rosa-Neto
Nature Aging - 2022 -
Sex influences clinical phenotype in frontotemporal
dementia
M. Pengo, A. Alberici, I. Libri, A. Benussi, Y. Gadola, Nicholas J. Ashton, Henrik Zetterberg, Kaj Blennow, B. Borroni
Neurological Sciences - 2022 -
Ante-mortem plasma phosphorylated tau (181) predicts Alzheimer's disease neuropathology and regional tau at
autopsy
M. S. Morrison, H. J. Aparicio, Kaj Blennow, Henrik Zetterberg, Nicholas J. Ashton, Thomas Karikari, Y. Tripodis, B. Martin, J. N. Palmisano, M. A. Sugarman, B. Frank, E. G. Steinberg, K. W. Turk, A. E. Budson, R. Au, L. E. Goldstein, G. R. Jun, N. W. Kowall, R. Killiany, W. Q. Qiu, R. A. Stern, J. Mez, A. C. McKee, T. D. Stein, M. L. Alosco
Brain - 2022 -
The extent of neuroradiological findings in COVID-19 shows correlation with blood biomarkers, Glasgow coma scale score and days in intensive
care.
David Fällmar, Elham Rostami, Eva Kumlien, Nicholas J. Ashton, Sven Jackmann, Radu Pavel, Kaj Blennow, Michael Hultström, Miklos Lipcsey, Robert Frithiof, Gabriel Westman, Henrik Zetterberg, Johan Wikström, Johan Virhammar
Journal of neuroradiology = Journal de neuroradiologie - 2022 -
N-terminal and mid-region tau fragments as fluid biomarkers in neurological
diseases.
Anniina Snellman, Juan Lantero Rodriguez, Andreja Emeršič, Agathe Vrillon, Thomas Karikari, Nicholas J. Ashton, Milica Gregorič Kramberger, Saša Čučnik, Claire Paquet, Uroš Rot, Henrik Zetterberg, Kaj Blennow
Brain : a journal of neurology - 2022 -
Differences Between Plasma and Cerebrospinal Fluid p-tau181 and p-tau231 in Early Alzheimer's
Disease.
Andrea Pilotto, Marta Parigi, Giulio Bonzi, Beatrice Battaglio, Elisabetta Ferrari, Lorenza Mensi, Alberto Benussi, Salvatore Caratozzolo, Maura Cosseddu, Rosanna Turrone, Silvana Archetti, Nicholas J. Ashton, Henrik Zetterberg, Silvia Giliani, Alessandro Padovani
Journal of Alzheimer's disease : JAD - 2022 -
Post-acute blood biomarkers and disease progression in traumatic brain
injury.
Virginia F J Newcombe, Nicholas J. Ashton, Jussi P Posti, Ben Glocker, Anne Manktelow, Doris A Chatfield, Stefan Winzeck, Edward Needham, Marta M Correia, Guy B Williams, Joel Simrén, Riikka S K Takala, Ari J Katila, Henna-Riikka Maanpää, Jussi Tallus, Janek Frantzén, Kaj Blennow, Olli Tenovuo, Henrik Zetterberg, David K Menon
Brain : a journal of neurology - 2022 -
Blood phospho-tau in Alzheimer disease: analysis, interpretation, and clinical
utility
Thomas Karikari, Nicholas J. Ashton, Gunnar Brinkmalm, Wagner S. Brum, Andréa Lessa Benedet, Laia Montoliu-Gaya, Juan Lantero Rodriguez, T. A. Pascoal, M. Suarez-Calvet, P. Rosa-Neto, Kaj Blennow, Henrik Zetterberg
Nature Reviews Neurology - 2022 -
Acute sleep loss increases CNS health biomarkers and compromises the ability to stay awake in a sex-and weight-specific
manner
L. T. van Egmond, S. Bukhari, Andréa Lessa Benedet, Nicholas J. Ashton, E. M. S. Meth, A. Boukas, J. Engstrom, M. Ilemosoglou, Kaj Blennow, Henrik Zetterberg, C. Benedict
Translational Psychiatry - 2022 -
Menopause hormone therapy significantly alters pathophysiological biomarkers of Alzheimer's
disease
D. Herman, V. Andrea, L. Pablo, L. Simone, Andréa Lessa Benedet, Nicholas J. Ashton, C. Enrica, Henrik Zetterberg, Kaj Blennow, V. Eugeen, H. Harald
Alzheimers & Dementia - 2022 -
Association of Plasma Biomarker Levels With Their CSF Concentration and the Number and Severity of Concussions in Professional
Athletes
Pashtun Shahim, Henrik Zetterberg, Joel Simrén, Nicholas J. Ashton, G. Norato, Michael Schöll, Y. Tegner, R. Diaz-Arrastia, Kaj Blennow
Neurology - 2022 -
Plasma p-tau231 and p-tau217 as state markers of amyloid-beta pathology in preclinical Alzheimer's
disease
M. Mila-Aloma, Nicholas J. Ashton, M. Shekari, G. Salvado, P. Ortiz-Romero, Laia Montoliu-Gaya, Andréa Lessa Benedet, Thomas Karikari, Juan Lantero Rodriguez, E. Vanmechelen, T. A. Day, A. Gonzalez-Escalante, G. Sanchez-Benavides, C. Minguillon, K. Fauria, J. L. Molinuevo, J. L. Dage, Henrik Zetterberg, J. D. Gispert, M. Suarez-Calvet, Kaj Blennow
Nature Medicine - 2022 -
Astrocyte biomarker signatures of amyloid-beta and tau pathologies in Alzheimer's
disease
J. P. Ferrari-Souza, P. C. L. Ferreira, B. Bellaver, C. Tissot, Y. T. Wang, D. T. Leffa, Wagner S. Brum, Andréa Lessa Benedet, Nicholas J. Ashton, M. A. De Bastiani, A. Rocha, J. Therriault, F. Z. Lussier, M. Chamoun, S. Servaes, G. Bezgin, M. S. Kang, J. Stevenson, N. Rahmouni, V. Pallen, N. M. Poltronetti, W. E. Klunk, D. L. Tudorascu, A. D. Cohen, V. L. Villemagne, S. Gauthier, Kaj Blennow, Henrik Zetterberg, D. O. Souza, Thomas Karikari, E. R. Zimmer, P. Rosa-Neto, T. A. Pascoal
Molecular Psychiatry - 2022 -
Is amyloid involved in acute neuroinflammation? A CSF analysis in
encephalitis
A. Padovani, A. Canale, L. Schiavon, S. Masciocchi, A. Imarisio, B. Risi, G. Bonzi, V. De Giuli, M. Di Luca, Nicholas J. Ashton, Kaj Blennow, Henrik Zetterberg, A. Pilotto
Alzheimers & Dementia - 2022 -
Effect of Race on Prediction of Brain Amyloidosis by Plasma Aβ42/Aβ40, Phosphorylated Tau, and Neurofilament
Light.
Suzanne E Schindler, Thomas Karikari, Nicholas J. Ashton, Rachel L Henson, Kevin E Yarasheski, Tim West, Mathew R Meyer, Kristopher M Kirmess, Yan Li, Benjamin Saef, Krista L Moulder, David Bradford, Anne M Fagan, Brian A Gordon, Tammie L S Benzinger, Joyce Balls-Berry, Randall J Bateman, Chengjie Xiong, Henrik Zetterberg, Kaj Blennow, John C Morris
Neurology - 2022 -
Differences and similarities between familial and sporadic frontotemporal dementia: An Italian single-center cohort
study
A. Benussi, I. Libri, E. Premi, A. Alberici, V. Cantoni, Y. Gadola, J. Rivolta, M. Pengo, S. Gazzina, V. D. Calhoun, R. Gasparotti, Henrik Zetterberg, Nicholas J. Ashton, Kaj Blennow, A. Padovani, B. Borroni
Alzheimer's and Dementia: Translational Research and Clinical Interventions - 2022 -
Quantification of SNAP-25 with mass spectrometry and Simoa: a method comparison in Alzheimer's
disease
Johanna Nilsson, Nicholas J. Ashton, Andréa Lessa Benedet, Laia Montoliu-Gaya, Johan Gobom, T. A. Pascoal, M. Chamoun, E. Portelius, A. Jeromin, M. Mendes, Henrik Zetterberg, P. Rosa-Neto, Ann Brinkmalm, Kaj Blennow
Alzheimer's Research & Therapy - 2022 -
Brain Injury Biomarkers for Predicting Outcome After Cardiac
Arrest
J. Humaloja, Nicholas J. Ashton, M. B. Skrifvars
Critical Care - 2022 -
Diagnostic value of serum versus plasma phospho-tau for Alzheimer's
disease
Przemyslaw R. Kac, Fernando Gonzalez-Ortiz, Joel Simrén, N. Dewit, E. Vanmechelen, Henrik Zetterberg, Kaj Blennow, Nicholas J. Ashton, Thomas Karikari
Alzheimer's Research & Therapy - 2022 -
Alzheimer's Disease Plasma Biomarkers Distinguish Clinical Diagnostic Groups in Memory Clinic
Patients
M. Gerards, A. K. Schild, D. Meiberth, A. Rostamzadeh, J. J. Vehreschild, S. Wingen-Heimann, W. Johannis, P. M. Adami, O. A. Onur, A. Ramirez, Thomas Karikari, Nicholas J. Ashton, Henrik Zetterberg, Kaj Blennow, F. Maier, F. Jessen
Dementia and Geriatric Cognitive Disorders - 2022 -
Plasma and CSF NfL are differentially associated with biomarker evidence of neurodegeneration in a community-based sample of
70-year-olds
Anna Dittrich, Nicholas J. Ashton, Henrik Zetterberg, Kaj Blennow, Joel Simrén, Fiona Geiger, Anna Zettergren, S. Shams, A. Machado, E. Westman, Michael Schöll, Ingmar Skoog, Silke Kern
Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring - 2022 -
Detecting amyloid positivity in early Alzheimer's disease using combinations of plasma A beta 42/A beta 40 and
p-tau
S. Janelidze, S. Palmqvist, A. Leuzy, E. Stomrud, I. M. W. Verberk, Henrik Zetterberg, Nicholas J. Ashton, P. Pesini, L. Sarasa, J. A. Allue, C. E. Teunissen, J. L. Dage, Kaj Blennow, N. Mattsson-Carlgren, O. Hansson
Alzheimers & Dementia - 2022 -
Decreased Electroencephalography Global Field Synchronization in Slow-Frequency Bands Characterizes Synaptic Dysfunction in Amnestic Subtypes of Mild Cognitive
Impairment.
Una Smailovic, Daniel Ferreira, Birgitta Ausén, Nicholas J. Ashton, Thomas Koenig, Henrik Zetterberg, Kaj Blennow, Vesna Jelic
Frontiers in aging neuroscience - 2022 -
A three-range approach enhances the prognostic utility of CSF biomarkers in Alzheimer's
disease.
Wagner S. Brum, Marco Antônio de Bastiani, Andrei Bieger, Joseph Therriault, João P Ferrari-Souza, Andréa Lessa Benedet, Paramita Saha-Chaudhuri, Diogo O Souza, Nicholas J. Ashton, Henrik Zetterberg, Tharick A Pascoal, Thomas Karikari, Kaj Blennow, Pedro Rosa-Neto, Eduardo R Zimmer
Alzheimer's & dementia (New York, N. Y.) - 2022 -
GFAp and tau protein as predictors of neurological outcome after out-of-hospital cardiac arrest: A post hoc analysis of the COMACARE
trial
J. Humaloja, M. Lähde, Nicholas J. Ashton, R. Matti, J. Hästbacka, P. Jakkula, H. Friberg, T. Cronberg, V. Pettilä, Kaj Blennow, Henrik Zetterberg, M. B. Skrifvars
Resuscitation - 2022 -
The accuracy and robustness of plasma biomarker models for amyloid PET
positivity
Andréa Lessa Benedet, Wagner S. Brum, O. Hansson, A. D. N. Initiative, Thomas Karikari, E. R. Zimmer, Henrik Zetterberg, Kaj Blennow, Nicholas J. Ashton
Alzheimers Research & Therapy - 2022 -
Association of Plasma p-tau181 and p-tau231 Concentrations With Cognitive Decline in Patients With Probable Dementia With Lewy
Bodies.
Maria C Gonzalez, Nicholas J. Ashton, Bárbara Fernandes Gomes, Diego Alejandro Tovar-Rios, Frédéric Blanc, Thomas Karikari, Brit Mollenhauer, Andrea Pilotto, Afina Lemstra, Claire Paquet, Carla Abdelnour, Milica G Kramberger, Laura Bonanni, Rik Vandenberghe, Abdul Hye, Kaj Blennow, Henrik Zetterberg, Dag Aarsland
JAMA neurology - 2022 -
Validation of the LUMIPULSE automated immunoassay for the measurement of core AD biomarkers in cerebrospinal
fluid.
Johan Gobom, Lucilla Parnetti, Pedro Rosa-Neto, Martin Vyhnalek, Serge Gauthier, Samuela Cataldi, Ondrej Lerch, Jan Laczo, Katerina Cechova, Marcus Clarin, Andrea I Benet, Tharick A Pascoal, Neserine Rahmouni, Manu Vandijck, Else Huyck, Nathalie Le Bastard, Jenna Stevenson, Mira Chamoun, Daniel Alcolea, Alberto Lleó, Ulf Andreasson, Marcel M Verbeek, Giovanni Bellomo, Roberta Rinaldi, Nicholas J. Ashton, Henrik Zetterberg, Katerina Sheardova, Jakub Hort, Kaj Blennow
Clinical chemistry and laboratory medicine - 2022 -
Plasma Cystatin C correlates with plasma NfL levels and predicts disease progression in Parkinson's
disease.
Alberto Imarisio, Andrea Pilotto, Emirena Garrafa, Francesca Conforti, Stefano Masciocchi, Rosanna Turrone, Stefano Gipponi, Elisabetta Cottini, Maria Cristina Rizzetti, Vanessa Porrini, Cristina Gussago, Marina Pizzi, Fiorella Guadagni, Henrik Zetterberg, Nicholas J. Ashton, Abdul Hye, Alessandro Padovani
Neuro-degenerative diseases - 2021 -
Plasma P-tau181 to Aβ42 ratio is associated with brain amyloid burden and hippocampal atrophy in an Asian cohort of Alzheimer's disease patients with concomitant cerebrovascular
disease.
Joyce R Chong, Nicholas J. Ashton, Thomas Karikari, Tomotaka Tanaka, Francis N Saridin, Anthonin Reilhac, Edward G Robins, Ying-Hwey Nai, Henri Vrooman, Saima Hilal, Henrik Zetterberg, Kaj Blennow, Mitchell K P Lai, Christopher P Chen
Alzheimer's & dementia : the journal of the Alzheimer's Association - 2021 -
Plasma sTREM2: a potential marker of cerebrovascular injury in neurodegenerative
disorders
E. Rodriguez-Vieitez, Nicholas J. Ashton
Brain - 2021 -
Association between polygenic risk score of Alzheimer's disease and plasma phosphorylated tau in individuals from the Alzheimer's Disease Neuroimaging
Initiative.
Anna Zettergren, Jodie Lord, Nicholas J. Ashton, Andréa Lessa Benedet, Thomas Karikari, Juan Lantero Rodriguez, Anniina Snellman, Marc Suárez-Calvet, Petroula Proitsi, Henrik Zetterberg, Kaj Blennow
Alzheimer's research & therapy - 2021 -
Neurofilament light as an outcome predictor after cardiac arrest: a post hoc analysis of the COMACARE
trial
L. Wihersaari, Nicholas J. Ashton, M. Reinikainen, P. Jakkula, V. Pettila, J. Hastbacka, M. Tiainen, P. Loisa, H. Friberg, T. Cronberg, Kaj Blennow, Henrik Zetterberg, M. B. Skrifvars
Intensive Care Medicine - 2021 -
Plasma pTau181 predicts cortical brain atrophy in aging and Alzheimer's
disease.
Cécile Tissot, Andréa Lessa Benedet, Joseph Therriault, Tharick A Pascoal, Firoza Z Lussier, Paramita Saha-Chaudhuri, Mira Chamoun, Melissa Savard, Sulantha S Mathotaarachchi, Gleb Bezgin, Yi-Ting Wang, Jaime Fernandez Arias, Juan Rodriguez, Anniina Snellman, Nicholas J. Ashton, Thomas Karikari, Kaj Blennow, Henrik Zetterberg, Etienne De Villers-Sidani, Philippe Huot, Serge Gauthier, Pedro Rosa-Neto
Alzheimer's research & therapy - 2021 -
Determining Amyloid-β Positivity Using 18F-AZD4694 PET
Imaging
J. Therriault, A. L. Benedet, T. A. Pascoal, M. Savard, Nicholas J. Ashton, M. Chamoun, C. Tissot, F. Lussier, M. S. Kang, G. Bezgin, T. Wang, J. Fernandes-Arias, G. Massarweh, P. Vitali, Henrik Zetterberg, Kaj Blennow, P. Saha-Chaudhuri, J. P. Soucy, S. Gauthier, P. Rosa-Neto
Journal of nuclear medicine : official publication, Society of Nuclear Medicine - 2021 -
Association of plasma P-tau181 with memory decline in non-demented
adults
J. Therriault, A. L. Benedet, T. A. Pascoal, F. Z. Lussier, C. Tissot, Thomas Karikari, Nicholas J. Ashton, M. Chamoun, G. Bezgin, S. Mathotaarachchi, S. Gauthier, P. Saha-Chaudhuri, Henrik Zetterberg, Kaj Blennow, P. Rosa-Neto
Brain Communications - 2021 -
Synaptic Molecular and Neurophysiological Markers Are Independent Predictors of Progression in Alzheimer's
Disease
U. Smailovic, I. Kareholt, T. Koenig, Nicholas J. Ashton, B. Winblad, K. Hoglund, P. Nilsson, Henrik Zetterberg, Kaj Blennow, V. Jelic
Journal of Alzheimers Disease - 2021 -
Blood neurofilament light in remote settings: Alternative protocols to support sample collection in challenging pre-analytical
conditions.
Joel Simrén, Nicholas J. Ashton, Kaj Blennow, Henrik Zetterberg
Alzheimer's & dementia - 2021 -
SARS-CoV-2 encephalitis is a cytokine release syndrome: evidences from cerebrospinal fluid
analyses.
Andrea Pilotto, Stefano Masciocchi, Irene Volonghi, Valeria De Giuli, Francesca Caprioli, Sara Mariotto, Sergio Ferrari, Silvia Bozzetti, Alberto Imarisio, Barbara Risi, Enrico Premi, Alberto Benussi, Emanuele Focà, Francesco Castelli, Gianluigi Zanusso, Salvatore Monaco, Paola Stefanelli, Roberto Gasparotti, Anastasia Zekeridou, Andrew McKeon, Nicholas J. Ashton, Kaj Blennow, Henrik Zetterberg, Alessandro Padovani
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America - 2021 -
Plasma GFAP is an early marker of amyloid-β but not tau pathology in Alzheimer's
disease.
Joana B Pereira, Shorena Janelidze, Ruben Smith, Niklas Mattsson-Carlgren, Sebastian Palmqvist, Charlotte E Teunissen, Henrik Zetterberg, Erik Stomrud, Nicholas J. Ashton, Kaj Blennow, Oskar Hansson
Brain : a journal of neurology - 2021 -
Serum and cerebrospinal fluid biomarker profiles in acute SARS-CoV-2-associated neurological
syndromes.
Ross W Paterson, Laura A Benjamin, Puja R Mehta, Rachel L Brown, Dilan Athauda, Nicholas J. Ashton, Claire A Leckey, Oliver J Ziff, Judith Heaney, Amanda J Heslegrave, Andréa Lessa Benedet, Kaj Blennow, Anna M Checkley, Catherine F Houlihan, Catherine J Mummery, Michael P Lunn, Hadi Manji, Michael S Zandi, Stephen Keddie, Michael Chou, Deepthi Vinayan Changaradil, Tom Solomon, Ashvini Keshavan, Suzanne Barker, Hans Rolf Jäger, Francesco Carletti, Robert Simister, David J Werring, Moira J Spyer, Eleni Nastouli, Serge Gauthier, Pedro Rosa-Neto, Henrik Zetterberg, Jonathan M Schott
Brain communications - 2021 -
Proteomic blood profiling in mild, severe and critical COVID-19
patients
H. Patel, Nicholas J. Ashton, R. J. B. Dobson, Lars-Magnus Andersson, Aylin Yilmaz, Kaj Blennow, Magnus Gisslén, Henrik Zetterberg
Scientific Reports - 2021 -
Microglial activation and tau propagate jointly across Braak
stages.
Tharick A Pascoal, Andrea L Benedet, Nicholas J. Ashton, Min Su Kang, Joseph Therriault, Mira Chamoun, Melissa Savard, Firoza Z Lussier, Cécile Tissot, Thomas Karikari, Julie Ottoy, Sulantha Mathotaarachchi, Jenna Stevenson, Gassan Massarweh, Michael Schöll, Mony J de Leon, Jean-Paul Soucy, Paul Edison, Kaj Blennow, Henrik Zetterberg, Serge Gauthier, Pedro Rosa-Neto
Nature medicine - 2021 -
Plasma phospho-tau181 in presymptomatic and symptomatic familial Alzheimer's disease: a longitudinal cohort
study
A. O'Connor, Thomas Karikari, T. Poole, Nicholas J. Ashton, Juan Rodriguez, A. Khatun, I. Swift, A. J. Heslegrave, E. Abel, E. Chung, P. S. J. Weston, I. M. Pavisic, N. S. Ryan, S. Barker, M. N. Rossor, J. M. Polke, C. Frost, S. Mead, Kaj Blennow, Henrik Zetterberg, N. C. Fox
Molecular Psychiatry - 2021 -
Cerebrospinal fluid biomarker panel for synaptic dysfunction in Alzheimer's
disease
Johanna Nilsson, Johan Gobom, Simon Sjödin, Gunnar Brinkmalm, Nicholas J. Ashton, Johan Svensson, Per Johansson, E. Portelius, Henrik Zetterberg, Kaj Blennow, Ann Brinkmalm
Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring - 2021 -
Complex Autoantibody Responses Occur following Moderate to Severe Traumatic Brain
Injury.
Edward J Needham, Oda Stoevesandt, Eric P Thelin, Henrik Zetterberg, Elisa R Zanier, Faiez Al Nimer, Nicholas J. Ashton, Joanne G Outtrim, Virginia F J Newcombe, Hani S Mousa, Joel Simrén, Kaj Blennow, Zhihui Yang, Peter J Hutchinson, Fredrik Piehl, Adel E Helmy, Mike J Taussig, Kevin K W Wang, Joanne L Jones, David K Menon, Alasdair J Coles
Journal of immunology - 2021 -
Time course of phosphorylated-tau181 in blood across the Alzheimer's disease
spectrum.
Alexis Moscoso Rial, Michel J. Grothe, Nicholas J. Ashton, Thomas Karikari, Juan Lantero Rodriguez, Anniina Snellman, Marc Suarez-Calvet, Henrik Zetterberg, Kaj Blennow, Michael Schöll
Brain : a journal of neurology - 2021 -
Longitudinal Associations of Blood Phosphorylated Tau181 and Neurofilament Light Chain With Neurodegeneration in Alzheimer
Disease.
Alexis Moscoso Rial, Michel J. Grothe, Nicholas J. Ashton, Thomas Karikari, Juan Lantero Rodriguez, Anniina Snellman, Marc Suárez-Calvet, Kaj Blennow, Henrik Zetterberg, Michael Schöll
JAMA Neurology - 2021 -
Blood Biomarkers for Alzheimer's Disease in Down
Syndrome
Laia Montoliu-Gaya, A. Strydom, Kaj Blennow, Henrik Zetterberg, Nicholas J. Ashton
Journal of Clinical Medicine - 2021 -
Plasma neurofilament light chain as a potential biomarker in Charcot-Marie-Tooth
disease.
Elina Millere, Dmitrijs Rots, Joel Simrén, Nicholas J. Ashton, Einars Kupats, Ieva Micule, Viktorija Priedite, Natalja Kurjane, Kaj Blennow, Linda Gailite, Henrik Zetterberg, Viktorija Kenina
European journal of neurology - 2021 -
CSF Synaptic Biomarkers in the Preclinical Stage of Alzheimer Disease and Their Association With MRI and PET: A Cross-sectional
Study.
Marta Milà-Alomà, Ann Brinkmalm, Nicholas J. Ashton, Hlin Kvartsberg, Mahnaz Shekari, Grégory Operto, Gemma Salvadó, Carles Falcon, Juan Domingo Gispert, Natalia Vilor-Tejedor, Eider M Arenaza-Urquijo, Oriol Grau-Rivera, Aleix Sala-Vila, Gonzalo Sanchez-Benavides, José María González-de-Echávarri, Carolina Minguillon, Karine Fauria, Aida Niñerola-Baizán, Andrés Perissinotti, Gwendlyn Kollmorgen, Ivonne Suridjan, Henrik Zetterberg, José Luis Molinuevo, Kaj Blennow, Marc Suárez-Calvet
Neurology - 2021 -
Comparison of Plasma Phosphorylated Tau Species With Amyloid and Tau Positron Emission Tomography, Neurodegeneration, Vascular Pathology, and Cognitive
Outcomes
M. M. Mielke, R. D. Frank, J. L. Dage, A. Jeromin, Nicholas J. Ashton, Kaj Blennow, Thomas Karikari, E. Vanmechelen, Henrik Zetterberg, A. Algeciras-Schimnich, D. S. Knopman, V. Lowe, G. J. Bu, P. Vemuri, J. Graff-Radford, C. R. Jack, R. C. Petersen
JAMA Neurology - 2021 -
Ultra-Early Differential Diagnosis of Acute Cerebral Ischemia and Hemorrhagic Stroke by Measuring the Prehospital Release Rate of
GFAP
O. S. Mattila, Nicholas J. Ashton, Kaj Blennow, Henrik Zetterberg, H. Harve-Rytsala, S. Pihlasviita, J. Ritvonen, G. Sibolt, T. Nukarinen, S. Curtze, D. Strbian, M. Pystynen, Turgut Tatlisumak, M. Kuisma, P. J. Lindsberg
Clinical Chemistry - 2021 -
Plasma levels of phosphorylated tau 181 are associated with cerebral metabolic dysfunction in cognitively impaired and amyloid-positive
individuals
F. Z. Lussier, A. L. Benedet, J. Therriault, T. A. Pascoal, C. Tissot, M. Chamoun, S. Mathotaarachchi, M. Savard, Nicholas J. Ashton, Thomas Karikari, Juan Rodriguez, Anniina Snellman, G. Bezgin, M. S. Kang, J. F. Arias, Y. T. Wang, S. Gauthier, Henrik Zetterberg, Kaj Blennow, P. Rosa-Neto
Brain Communications - 2021 -
A genome-wide association study of plasma phosphorylated
tau181
Jodie Lord, Anna Zettergren, Nicholas J. Ashton, Thomas Karikari, Andréa Lessa Benedet, Joel Simrén, Abdul Hye, Dag Aarsland, Kaj Blennow, Henrik Zetterberg, Petroula Proitsi
Neurobiology of aging - 2021 -
Phosphorylated tau181 in plasma as a potential biomarker for Alzheimer's disease in adults with Down
syndrome
A. Lleo, Henrik Zetterberg, J. Pegueroles, Thomas Karikari, M. Carmona-Iragui, Nicholas J. Ashton, V. Montal, I. Barroeta, Juan Lantero Rodriguez, L. Videla, M. Altuna, B. Benejam, S. Fernandez, S. Valldeneu, D. Garzon, A. Bejanin, M. F. Iulita, V. Camacho, S. Medrano-Martorell, O. Belbin, J. Clarimon, S. Lehmann, D. Alcolea, R. Blesa, Kaj Blennow, J. Fortea
Nature Communications - 2021 -
P-tau235: a novel biomarker for staging preclinical Alzheimer's
disease.
Juan Lantero Rodriguez, Anniina Snellman, Andréa Lessa Benedet, Marta Milà-Alomà, Elena Camporesi, Laia Montoliu-Gaya, Nicholas J. Ashton, Agathe Vrillon, Thomas Karikari, Juan Domingo Gispert, Gemma Salvadó, Mahnaz Shekari, Christina E Toomey, Tammaryn L Lashley, Henrik Zetterberg, Marc Suárez-Calvet, Gunnar Brinkmalm, Pedro Rosa Neto, Kaj Blennow
EMBO molecular medicine - 2021 -
Population-based blood screening for preclinical Alzheimer's disease in a British birth cohort at age
70.
Ashvini Keshavan, Josef Pannee, Thomas Karikari, Juan Rodriguez, Nicholas J. Ashton, Jennifer M Nicholas, David M Cash, William Coath, Christopher A Lane, Thomas D Parker, Kirsty Lu, Sarah M Buchanan, Sarah E Keuss, Sarah-Naomi James, Heidi Murray-Smith, Andrew Wong, Anna Barnes, John C Dickson, Amanda Heslegrave, Erik Portelius, Marcus Richards, Nick C Fox, Henrik Zetterberg, Kaj Blennow, Jonathan M Schott
Brain : a journal of neurology - 2021 -
Diagnostic performance and prediction of clinical progression of plasma phospho-tau181 in the Alzheimer's Disease Neuroimaging
Initiative.
Thomas Karikari, Andréa L Benedet, Nicholas J. Ashton, Juan Lantero Rodriguez, Anniina Snellman, Marc Suárez-Calvet, Paramita Saha-Chaudhuri, Firoza Lussier, Hlin Kvartsberg, Alexis Moscoso Rial, Tharick A Pascoal, Ulf Andreasson, Michael Schöll, Michael W Weiner, Pedro Rosa-Neto, John Q Trojanowski, Leslie M Shaw, Kaj Blennow, Henrik Zetterberg
Molecular psychiatry - 2021 -
Neurochemical signs of astrocytic and neuronal injury in acute COVID-19 normalizes during long-term
follow-up.
Nelly Kanberg, Joel Simrén, Arvid Edén, Lars-Magnus Andersson, Staffan Nilsson, Nicholas J. Ashton, Pär-Daniel Sundvall, Bengt Nellgård, Kaj Blennow, Henrik Zetterberg, Magnus Gisslén
EBioMedicine - 2021 -
Associations of Fully Automated CSF and Novel Plasma Biomarkers With Alzheimer Disease Neuropathology at
Autopsy.
Michel J. Grothe, Alexis Moscoso Rial, Nicholas J. Ashton, Thomas Karikari, Juan Lantero Rodriguez, Anniina Snellman, Henrik Zetterberg, Kaj Blennow, Michael Schöll
Neurology - 2021 -
Saliva Neurofilament Light Chain Is Not a Diagnostic Biomarker for Neurodegeneration in a Mixed Memory Clinic
Population
H. S. Gleerup, Federica Sanna, P. Hogh, Joel Simrén, Kaj Blennow, Henrik Zetterberg, S. G. Hasselbalch, Nicholas J. Ashton, A. H. Simonsen
Frontiers in Aging Neuroscience - 2021 -
Critical illness polyneuropathy, myopathy and neuronal biomarkers in COVID-19 patients: A prospective
study
R. Frithiof, E. Rostami, E. Kumlien, J. Virhammar, D. Fallmar, M. Hultstrom, M. Lipcsey, Nicholas J. Ashton, Kaj Blennow, Henrik Zetterberg, A. R. Punga
Clinical Neurophysiology - 2021 -
Blood-based high sensitivity measurements of beta-amyloid and phosphorylated tau as biomarkers of Alzheimer's disease: a focused review on recent
advances
J. R. Chong, Nicholas J. Ashton, Thomas Karikari, T. Tanaka, Michael Schöll, Henrik Zetterberg, Kaj Blennow, C. P. Chen, M. K. P. Lai
Journal of Neurology Neurosurgery and Psychiatry - 2021 -
Prodromal frontotemporal dementia: clinical features and predictors of
progression.
Alberto Benussi, Nicholas J. Ashton, Thomas Karikari, Antonella Alberici, Claudia Saraceno, Roberta Ghidoni, Luisa Benussi, Henrik Zetterberg, Kaj Blennow, Barbara Borroni
Alzheimer's research & therapy - 2021 -
Differences Between Plasma and Cerebrospinal Fluid Glial Fibrillary Acidic Protein Levels Across the Alzheimer Disease
Continuum
Andréa Lessa Benedet, M. Mila-Aloma, A. Vrillon, Nicholas J. Ashton, T. A. Pascoal, F. Lussier, Thomas Karikari, C. Hourregue, E. Cognat, J. Dumurgier, J. Stevenson, N. Rahmouni, V. Pallen, N. M. Poltronetti, G. Salvado, M. Shekari, G. Operto, J. D. Gispert, C. Minguillon, K. Fauria, G. Kollmorgen, I. Suridjan, E. R. Zimmer, Henrik Zetterberg, J. L. Molinuevo, C. Paquet, P. Rosa-Neto, Kaj Blennow, M. Suarez-Calvet
Jama Neurology - 2021 -
Clinical and analytical comparison of six Simoa assays for plasma P-tau isoforms P-tau181, P-tau217, and
P-tau231.
Sherif Bayoumy, Inge M W Verberk, Ben den Dulk, Zulaiga Hussainali, Marissa Zwan, Wiesje M van der Flier, Nicholas J. Ashton, Henrik Zetterberg, Kaj Blennow, Jeroen Vanbrabant, Erik Stoops, Eugeen Vanmechelen, Jeffrey L Dage, Charlotte E Teunissen
Alzheimer's research & therapy - 2021 -
Effects of pre-analytical procedures on blood biomarkers for Alzheimer's pathophysiology, glial activation, and
neurodegeneration.
Nicholas J. Ashton, Marc Suárez-Calvet, Thomas Karikari, Juan Lantero Rodriguez, Anniina Snellman, Joel Simrén, Carolina Minguillon, Karine Fauria, Kaj Blennow, Henrik Zetterberg
Alzheimer's & dementia (Amsterdam, Netherlands) - 2021 -
Plasma p-tau231: a new biomarker for incipient Alzheimer's disease
pathology.
Nicholas J. Ashton, Tharick A Pascoal, Thomas Karikari, Andréa Lessa Benedet, Juan Lantero Rodriguez, Gunnar Brinkmalm, Anniina Snellman, Michael Schöll, Claire Troakes, Abdul Hye, Serge Gauthier, Eugeen Vanmechelen, Henrik Zetterberg, Pedro Rosa-Neto, Kaj Blennow
Acta neuropathologica - 2021 -
Spitting image: can saliva biomarkers reflect Alzheimer's
disease?
Nicholas J. Ashton, Kaj Blennow, Henrik Zetterberg
EBioMedicine - 2021 -
Use of plasma biomarkers for AT(N) classification of neurodegenerative
dementias
D. Alcolea, C. Delaby, L. Muñoz, S. Torres, T. Estellés, N. Zhu, I. Barroeta, M. Carmona-Iragui, I. Illán-Gala, M. Á Santos-Santos, M. Altuna, I. Sala, Mª B. Sánchez-Saudinós, L. Videla, S. Valldeneu, A. Subirana, J. Pegueroles, C. Hirtz, J. Vialaret, S. Lehmann, Thomas Karikari, Nicholas J. Ashton, Kaj Blennow, Henrik Zetterberg, O. Belbin, R. Blesa, J. Clarimón, J. Fortea, A. Lleó
Journal of Neurology, Neurosurgery and Psychiatry - 2021 -
Transitioning from cerebrospinal fluid to blood tests to facilitate diagnosis and disease monitoring in Alzheimer's
disease.
Deborah O T Alawode, Amanda J Heslegrave, Nicholas J. Ashton, Thomas Karikari, Joel Simrén, Laia Montoliu-Gaya, Josef Pannee, Antoinette O Connor, Philip S J Weston, Juan Lantero Rodriguez, Ashvini Keshavan, Anniina Snellman, Johan Gobom, Ross W Paterson, Jonathan M Schott, Kaj Blennow, Nick C Fox, Henrik Zetterberg
Journal of internal medicine - 2021 -
Publisher Correction: Microglial activation and tau propagate jointly across Braak
stages.
Tharick A Pascoal, Andréa Lessa Benedet, Nicholas J. Ashton, Min Su Kang, Joseph Therriault, Mira Chamoun, Melissa Savard, Firoza Z Lussier, Cécile Tissot, Thomas Karikari, Julie Ottoy, Sulantha Mathotaarachchi, Jenna Stevenson, Gassan Massarweh, Michael Schöll, Mony J de Leon, Jean-Paul Soucy, Paul Edison, Kaj Blennow, Henrik Zetterberg, Serge Gauthier, Pedro Rosa-Neto
Nature medicine - 2021 -
Changes in Blood Biomarkers of Brain Injury and Degeneration Following Long-Duration
Spaceflight.
Peter Zu Eulenburg, Judith-Irina Buchheim, Nicholas J. Ashton, Galina Vassilieva, Kaj Blennow, Henrik Zetterberg, Alexander Choukér
JAMA neurology - 2021 -
Biomarkers for central nervous system injury in cerebrospinal fluid are elevated in COVID-19 and associated with neurological symptoms and disease
severity
J. Virhammar, A. Naas, D. Fallmar, J. L. Cunningham, A. Klang, Nicholas J. Ashton, S. Jackmann, G. Westman, R. Frithiof, Kaj Blennow, Henrik Zetterberg, E. Kumlien, E. Rostami
European Journal of Neurology - 2021 -
Head-to-head comparison of amplified plasmonic exosome Aβ42 platform and single-molecule array immunoassay in a memory clinic
cohort.
Tomotaka Tanaka, Joyce Chong Ruifen, Ying-Hwey Nai, Chin Hong Tan, Carine Z J Lim, Yan Zhang, Mary C Stephenson, Saima Hilal, Francis N Saridin, Bibek Gyanwali, Steven Villaraza, Edward G Robins, Masafumi Ihara, Michael Schöll, Henrik Zetterberg, Kaj Blennow, Nicholas J. Ashton, Huilin Shao, Anthonin Reilhac, Christopher Chen
European journal of neurology - 2021 -
The diagnostic and prognostic capabilities of plasma biomarkers in Alzheimer's
disease.
Joel Simrén, Antoine Leuzy, Thomas Karikari, Abdul Hye, Andréa Lessa Benedet, Juan Lantero Rodriguez, Niklas Mattsson-Carlgren, Michael Schöll, Patrizia Mecocci, Bruno Vellas, Magda Tsolaki, Iwona Kloszewska, Hilkka Soininen, Simon Lovestone, Dag Aarsland, Oskar Hansson, Pedro Rosa-Neto, Eric Westman, Kaj Blennow, Henrik Zetterberg, Nicholas J. Ashton
Alzheimer's & dementia : the journal of the Alzheimer's Association - 2021 -
The validation status of blood biomarkers of amyloid and phospho-tau assessed with the 5-phase development framework for AD
biomarkers
Nicholas J. Ashton, A. Leuzy, Thomas Karikari, N. Mattsson-Carlgren, A. Dodich, M. Boccardi, J. Corre, A. Drzezga, A. Nordberg, R. Ossenkoppele, Henrik Zetterberg, Kaj Blennow, G. B. Frisoni, V. Garibotto, O. Hansson
European Journal of Nuclear Medicine and Molecular Imaging - 2021 -
The reliability and validity of DSM 5 diagnostic criteria for neurocognitive disorder and relationship with plasma neurofilament light in a down syndrome
population
S. E. Pape, T. Al Janabi, Nicholas J. Ashton, A. Hye, R. Sheehan, P. Gallagher, B. Knight, A. M. Prins, K. Courtenay, V. Jordanova, B. Thomas, N. Perumal, C. Forbes, A. Hassiotis, A. Strydom
Scientific Reports - 2021 -
A multicentre validation study of the diagnostic value of plasma neurofilament
light.
Nicholas J. Ashton, Shorena Janelidze, Ahmad Al Khleifat, Antoine Leuzy, Emma L van der Ende, Thomas Karikari, Andrea L Benedet, Tharick A Pascoal, Alberto Lleó, Lucilla Parnetti, Daniela Galimberti, Laura Bonanni, Andrea Pilotto, Alessandro Padovani, Jan Lycke, Lenka Novakova, Markus Axelsson, Latha Velayudhan, Gil D Rabinovici, Bruce Miller, Carmine Pariante, Naghmeh Nikkheslat, Susan M Resnick, Madhav Thambisetty, Michael Schöll, Gorka Fernández-Eulate, Francisco J Gil-Bea, Adolfo López de Munain, Ammar Al-Chalabi, Pedro Rosa-Neto, Andre Strydom, Per Svenningsson, Erik Stomrud, Alexander Santillo, Dag Aarsland, John C van Swieten, Sebastian Palmqvist, Henrik Zetterberg, Kaj Blennow, Abdul Hye, Oskar Hansson
Nature communications - 2021 -
Plasma Neurofilament Light Chain Predicts Cognitive Progression in Prodromal and Clinical Dementia with Lewy
Bodies
A. Pilotto, A. Imarisio, C. Carrarini, M. Russo, S. Masciocchi, S. Gipponi, E. Cottini, D. Aarsland, Henrik Zetterberg, Nicholas J. Ashton, A. Hye, L. Bonanni, A. Padovani
Journal of Alzheimers Disease - 2021 -
Plasma NfL, clinical subtypes and motor progression in Parkinson's
disease
A. Pilotto, A. Imarisio, F. Conforti, A. Scalvini, S. Masciocchi, S. Nocivelli, R. Turrone, S. Gipponi, E. Cottini, B. Borroni, M. C. Rizzetti, M. Pizzi, L. Bonanni, A. Sturchio, A. J. Espay, Henrik Zetterberg, Nicholas J. Ashton, A. Hye, A. Padovani
Parkinsonism & Related Disorders - 2021 -
2020 update on the clinical validity of cerebrospinal fluid amyloid, tau, and phospho-tau as biomarkers for Alzheimer's disease in the context of a structured 5-phase development
framework
A. Leuzy, Nicholas J. Ashton, N. Mattsson-Carlgren, A. Dodich, M. Boccardi, J. Corre, A. Drzezga, A. Nordberg, R. Ossenkoppele, Henrik Zetterberg, Kaj Blennow, G. B. Frisoni, V. Garibotto, O. Hansson
European Journal of Nuclear Medicine and Molecular Imaging - 2021 -
The strategic biomarker roadmap for the validation of Alzheimer's diagnostic biomarkers: methodological
update
M. Boccardi, A. Dodich, E. Albanese, A. Gayet-Ageron, C. Festari, Nicholas J. Ashton, G. N. Bischof, K. Chiotis, A. Leuzy, E. E. Wolters, M. A. Walter, G. D. Rabinovici, M. Carrillo, A. Drzezga, O. Hansson, A. Nordberg, R. Ossenkoppele, V. L. Villemagne, B. Winblad, G. B. Frisoni, V. Garibotto
European Journal of Nuclear Medicine and Molecular Imaging - 2021 -
Head-to-head comparison of clinical performance of CSF phospho-tau T181 and T217 biomarkers for Alzheimer's disease
diagnosis.
Thomas Karikari, Agathe Vrillon, Juan Lantero Rodriguez, Nicholas J. Ashton, Milica Gregorič Kramberger, Julien Dumurgier, Claire Hourregue, Saša Čučnik, Gunnar Brinkmalm, Uroš Rot, Henrik Zetterberg, Claire Paquet, Kaj Blennow
Alzheimer's & dementia : the journal of the Alzheimer's Association - 2021 -
Propagation of Tau Pathology: Integrating Insights From Postmortem and In Vivo
Studies.
Thomas Vogels, Antoine Leuzy, Claudia Cicognola, Nicholas J. Ashton, Tomas Smolek, Michal Novak, Kaj Blennow, Henrik Zetterberg, Tomas Hromadka, Norbert Zilka, Michael Schöll
Biological psychiatry - 2020 -
Novel tau biomarkers phosphorylated at T181, T217 or T231 rise in the initial stages of the preclinical Alzheimer's continuum when only subtle changes in Aβ pathology are
detected.
Marc Suárez-Calvet, Thomas Karikari, Nicholas J. Ashton, Juan Lantero Rodriguez, Marta Milà-Alomà, Juan Domingo Gispert, Gemma Salvadó, Carolina Minguillon, Karine Fauria, Mahnaz Shekari, Oriol Grau-Rivera, Eider M Arenaza-Urquijo, Aleix Sala-Vila, Gonzalo Sánchez-Benavides, José Maria González-de-Echávarri, Gwendlyn Kollmorgen, Erik Stoops, Eugeen Vanmechelen, Henrik Zetterberg, Kaj Blennow, José Luis Molinuevo
EMBO molecular medicine - 2020 -
An update on fluid biomarkers for neurodegenerative diseases: recent success and challenges
ahead.
Joel Simrén, Nicholas J. Ashton, Kaj Blennow, Henrik Zetterberg
Current opinion in neurobiology - 2020 -
Full-length and C-terminal neurogranin in Alzheimer's disease cerebrospinal fluid analyzed by novel ultrasensitive
immunoassays
Annika Öhrfelt, J. Dumurgier, Henrik Zetterberg, A. Vrillon, Nicholas J. Ashton, Hlin Kvartsberg, E. Bouaziz-Amar, J. Hugon, C. Paquet, Kaj Blennow
Alzheimers Research & Therapy - 2020 -
Perspectives in fluid biomarkers in neurodegeneration from the 2019 biomarkers in neurodegenerative diseases course-a joint PhD student course at University College London and University of
Gothenburg.
Pawel Obrocki, Ayesha Khatun, Deborah Ness, Konstantin Senkevich, Jörg Hanrieder, Federica Capraro, Niklas Mattsson, Ulf Andreasson, Erik Portelius, Nicholas J. Ashton, Kaj Blennow, Michael Schöll, Ross W Paterson, Jonathan M Schott, Henrik Zetterberg
Alzheimer's research & therapy - 2020 -
Comparing Glial Fibrillary Acidic Protein (GFAP) in Serum and Plasma Following Mild Traumatic Brain Injury in Older
Adults.
Nathan A Huebschmann, Teemu M Luoto, Justin E Karr, Ksenia Berghem, Kaj Blennow, Henrik Zetterberg, Nicholas J. Ashton, Joel Simrén, Jussi P Posti, Jessica M Gill, Grant L Iverson
Frontiers in neurology - 2020 -
Relevance of biomarkers across different
neurodegenerative.
Alexander J Ehrenberg, Ayesha Khatun, Emma Coomans, Matthew J Betts, Federica Capraro, Elisabeth H Thijssen, Konstantin Senkevich, Tehmina Bharucha, Mehrsa Jafarpour, Peter N E Young, William Jagust, Stephen F Carter, Tammaryn Lashley, Lea T Grinberg, Joana B Pereira, Niklas Mattsson-Carlgren, Nicholas J. Ashton, Jörg Hanrieder, Henrik Zetterberg, Michael Schöll, Ross W Paterson
Alzheimer's research & therapy - 2020 -
Serum Hepcidin Levels in Cognitively Normal Older Adults with High Neocortical Amyloid-beta
Load
P. Chatterjee, M. Mohammadi, K. Goozee, T. M. Shah, H. R. Sohrabi, C. B. Dias, K. K. Shen, P. R. Asih, P. Dave, S. Pedrini, Nicholas J. Ashton, A. Hye, K. Taddei, D. B. Lovejoy, Henrik Zetterberg, Kaj Blennow, R. N. Martins
Journal of Alzheimers Disease - 2020 -
Fluid Biomarkers for Synaptic Dysfunction and
Loss
Elena Camporesi, Johanna Nilsson, Ann Brinkmalm, Bruno Becker, Nicholas J. Ashton, Kaj Blennow, Henrik Zetterberg
Biomarker Insights - 2020 -
Diagnostic and prognostic value of serum NfL and p-Tau181 in frontotemporal lobar
degeneration.
Alberto Benussi, Thomas Karikari, Nicholas J. Ashton, Stefano Gazzina, Enrico Premi, Luisa Benussi, Roberta Ghidoni, Juan Lantero Rodriguez, Andreja Emersic, Joel Simrén, Giuliano Binetti, Silvia Fostinelli, Marcello Giunta, Roberto Gasparotti, Henrik Zetterberg, Kaj Blennow, Barbara Borroni
Journal of neurology, neurosurgery, and psychiatry - 2020 -
Serum Glial Fibrillary Acidic Protein (GFAP) Is a Marker of Disease Severity in Frontotemporal Lobar
Degeneration.
Alberto Benussi, Nicholas J. Ashton, Thomas Karikari, Stefano Gazzina, Enrico Premi, Luisa Benussi, Roberta Ghidoni, Juan Lantero Rodriguez, Andreja Emersic, Giuliano Binetti, Silvia Fostinelli, Marcello Giunta, Roberto Gasparotti, Henrik Zetterberg, Kaj Blennow, Barbara Borroni
Journal of Alzheimer's disease : JAD - 2020 -
Stage-specific links between plasma neurofilament light and imaging biomarkers of Alzheimer's
disease.
Andréa Lessa Benedet, Antoine Leuzy, Nicholas J. Ashton, Sulantha Mathotaarachchi, Melissa Savard, Joseph Therriault, Min Su Kang, Mira Chamoun, Michael Schöll, Eduardo R Zimmer, Serge Gauthier, Aurélie Labbe, Henrik Zetterberg, Pedro Rosa-Neto, Kaj Blennow
Brain : a journal of neurology - 2020 -
An update on blood-based biomarkers for non-Alzheimer neurodegenerative
disorders.
Nicholas J. Ashton, Abdul Hye, Anto P Rajkumar, Antoine Leuzy, Stuart Snowden, Marc Suárez-Calvet, Thomas Karikari, Michael Schöll, Renaud La Joie, Gil D Rabinovici, Kina Höglund, Clive Ballard, Tibor Hortobágyi, Per Svenningsson, Kaj Blennow, Henrik Zetterberg, Dag Aarsland
Nature Reviews Neurology - 2020 -
Dickkopf-1 Overexpression in vitro Nominates Candidate Blood Biomarkers Relating to Alzheimer's Disease
Pathology.
Liu Shi, Laura M Winchester, Benjamine Y Liu, Richard Killick, Elena M Ribe, Sarah Westwood, Alison L Baird, Noel J Buckley, Shengjun Hong, Valerija Dobricic, Fabian Kilpert, Andre Franke, Steven Kiddle, Martina Sattlecker, Richard Dobson, Antonio Cuadrado, Abdul Hye, Nicholas J. Ashton, Angharad R Morgan, Isabelle Bos, Stephanie J B Vos, Mara Ten Kate, Philip Scheltens, Rik Vandenberghe, Silvy Gabel, Karen Meersmans, Sebastiaan Engelborghs, Ellen E De Roeck, Kristel Sleegers, Giovanni B Frisoni, Olivier Blin, Jill C Richardson, Régis Bordet, José L Molinuevo, Lorena Rami, Anders Wallin, Petronella Kettunen, Magda Tsolaki, Frans Verhey, Alberto Lleó, Daniel Alcolea, Julius Popp, Gwendoline Peyratout, Pablo Martinez-Lage, Mikel Tainta, Peter Johannsen, Charlotte E Teunissen, Yvonne Freund-Levi, Lutz Frölich, Cristina Legido-Quigley, Frederik Barkhof, Kaj Blennow, Katrine Laura Rasmussen, Børge Grønne Nordestgaard, Ruth Frikke-Schmidt, Sune Fallgaard Nielsen, Hilkka Soininen, Bruno Vellas, Iwona Kloszewska, Patrizia Mecocci, Henrik Zetterberg, B Paul Morgan, Johannes Streffer, Pieter Jelle Visser, Lars Bertram, Alejo J Nevado-Holgado, Simon Lovestone
Journal of Alzheimer's disease : JAD - 2020 -
Urinary metabolic phenotyping for Alzheimer's
disease
N. Kurbatova, M. Garg, L. Whiley, E. Chekmeneva, B. Jimenez, M. Gomez-Romero, J. Pearce, T. Kimhofer, E. D'Hondt, H. Soininen, I. Kloszewska, P. Mecocci, M. Tsolaki, B. Vellas, D. Aarsland, A. Nevado-Holgado, B. Liu, S. Snowden, P. Proitsi, Nicholas J. Ashton, A. Hye, C. Legido-Quigley, M. R. Lewis, J. K. Nicholson, E. Holmes, A. Brazma, S. Lovestone
Scientific Reports - 2020 -
Blood phosphorylated tau 181 as a biomarker for Alzheimer's disease: a diagnostic performance and prediction modelling study using data from four prospective
cohorts.
Thomas Karikari, Tharick A Pascoal, Nicholas J. Ashton, Shorena Janelidze, Andréa Lessa Benedet, Juan Lantero Rodriguez, Mira Chamoun, Melissa Savard, Min Su Kang, Joseph Therriault, Michael Schöll, Gassan Massarweh, Jean-Paul Soucy, Kina Höglund, Gunnar Brinkmalm, Niklas Mattsson, Sebastian Palmqvist, Serge Gauthier, Erik Stomrud, Henrik Zetterberg, Oskar Hansson, Pedro Rosa-Neto, Kaj Blennow
The Lancet. Neurology - 2020 -
Neurochemical evidence of astrocytic and neuronal injury commonly found in
COVID-19.
Nelly Kanberg, Nicholas J. Ashton, Lars-Magnus Andersson, Aylin Yilmaz, Magnus Lindh, Staffan Nilsson, Richard W Price, Kaj Blennow, Henrik Zetterberg, Magnus Gisslén
Neurology - 2020 -
Steroid-Responsive Encephalitis in Coronavirus Disease
2019
A. Pilotto, S. Odolini, S. Masciocchi, A. Comelli, I. Volonghi, S. Gazzina, S. Nocivelli, A. Pezzini, E. Foca, A. Caruso, M. Leonardi, M. P. Pasolini, R. Gasparotti, F. Castelli, Nicholas J. Ashton, Kaj Blennow, Henrik Zetterberg, A. Padovani
Annals of Neurology - 2020 -
Plasma p-tau181 accurately predicts Alzheimer's disease pathology at least 8 years prior to post-mortem and improves the clinical characterisation of cognitive
decline.
Juan Lantero Rodriguez, Thomas Karikari, Marc Suárez-Calvet, Claire Troakes, Andrew King, Andreja Emersic, Dag Aarsland, Abdul Hye, Henrik Zetterberg, Kaj Blennow, Nicholas J. Ashton
Acta neuropathologica - 2020 -
Plasma transferrin and hemopexin are associated with altered A beta uptake and cognitive decline in Alzheimer's disease
pathology
A. Ashraf, Nicholas J. Ashton, P. Chatterjee, K. Goozee, K. K. Shen, J. Fripp, D. Ames, C. Rowe, C. L. Masters, V. Villemagne, A. Hye, R. N. Martins, P. W. So
Alzheimers Research & Therapy - 2020 -
Validation of Plasma Proteomic Biomarkers Relating to Brain Amyloid Burden in the EMIF-Alzheimer's Disease Multimodal Biomarker Discovery
Cohort.
Sarah Westwood, Alison L Baird, Sneha N Anand, Alejo J Nevado-Holgado, Andrey Kormilitzin, Liu Shi, Abdul Hye, Nicholas J. Ashton, Angharad R Morgan, Isabelle Bos, Stephanie J B Vos, Susan Baker, Noel J Buckley, Mara Ten Kate, Philip Scheltens, Charlotte E Teunissen, Rik Vandenberghe, Silvy Gabel, Karen Meersmans, Sebastiaan Engelborghs, Ellen E De Roeck, Kristel Sleegers, Giovanni B Frisoni, Olivier Blin, Jill C Richardson, Régis Bordet, José L Molinuevo, Lorena Rami, Anders Wallin, Petronella Kettunen, Magda Tsolaki, Frans Verhey, Alberto Lléo, Isabel Sala, Julius Popp, Gwendoline Peyratout, Pablo Martinez-Lage, Mikel Tainta, Peter Johannsen, Yvonne Freund-Levi, Lutz Frölich, Valerija Dobricic, Cristina Legido-Quigley, Lars Bertram, Frederik Barkhof, Henrik Zetterberg, B Paul Morgan, Johannes Streffer, Pieter Jelle Visser, Simon Lovestone
Journal of Alzheimer's disease : JAD - 2020 -
Comparative analysis of obesity-related cardiometabolic and renal biomarkers in human plasma and
serum.
Meenu Rohin Rajan, Matus Sotak, Fredrik Barrenäs, Tong Shen, Kamil Borkowski, Nicholas J. Ashton, Christina Biörserud, Tomas L Lindahl, Sofia Ramström, Michael Schöll, Per Lindahl, Oliver Fiehn, John W Newman, Rosie Perkins, Ville Wallenius, Stephan Lange, Emma Börgeson
Scientific reports - 2019 -
Plasma neurofilament light chain and amyloid-β are associated with the kynurenine pathway metabolites in preclinical Alzheimer's
disease.
Pratishtha Chatterjee, Henrik Zetterberg, Kathryn Goozee, Chai K Lim, Kelly R Jacobs, Nicholas J. Ashton, Abdul Hye, Steve Pedrini, Hamid R Sohrabi, Tejal Shah, Prita R Asih, Preeti Dave, Kaikai Shen, Kevin Taddei, David B Lovejoy, Gilles J Guillemin, Kaj Blennow, Ralph N Martins
Journal of neuroinflammation - 2019 -
Plasma neurofilament light associates with Alzheimer's disease metabolic decline in amyloid-positive
individuals.
Andréa L Benedet, Nicholas J. Ashton, Tharick A Pascoal, Antoine Leuzy, Sulantha Mathotaarachchi, Min S Kang, Joseph Therriault, Melissa Savard, Mira Chamoun, Michael Schöll, Eduardo R Zimmer, Serge Gauthier, Aurélie Labbe, Henrik Zetterberg, Kaj Blennow, Pedro R Neto
Alzheimer's & dementia - 2019 -
Salivary Biomarkers for Alzheimer's Disease and Related
Disorders.
Nicholas J. Ashton, Mark Ide, Henrik Zetterberg, Kaj Blennow
Neurology and therapy - 2019 -
Plasma levels of soluble TREM2 and neurofilament light chain in TREM2 rare variant
carriers.
Nicholas J. Ashton, Marc Suarez-Calvet, Amanda Heslegrave, Abdul Hye, Cristina Razquin, Pau Pastor, Raquel Sanchez-Valle, José L Molinuevo, Pieter Jelle Visser, Kaj Blennow, Angela K Hodges, Henrik Zetterberg
Alzheimer's research & therapy - 2019 -
Discovery and validation of plasma proteomic biomarkers relating to brain amyloid burden by SOMAscan
assay.
Liu Shi, Sarah Westwood, Alison L Baird, Laura Winchester, Valerija Dobricic, Fabian Kilpert, Shengjun Hong, Andre Franke, Abdul Hye, Nicholas J. Ashton, Angharad R Morgan, Isabelle Bos, Stephanie J B Vos, Noel J Buckley, Mara Ten Kate, Philip Scheltens, Rik Vandenberghe, Silvy Gabel, Karen Meersmans, Sebastiaan Engelborghs, Ellen E De Roeck, Kristel Sleegers, Giovanni B Frisoni, Olivier Blin, Jill C Richardson, Régis Bordet, José L Molinuevo, Lorena Rami, Anders Wallin, Petronella Kettunen, Magda Tsolaki, Frans Verhey, Alberto Lleó, Daniel Alcolea, Julius Popp, Gwendoline Peyratout, Pablo Martinez-Lage, Mikel Tainta, Peter Johannsen, Charlotte E Teunissen, Yvonne Freund-Levi, Lutz Frölich, Cristina Legido-Quigley, Frederik Barkhof, Kaj Blennow, Henrik Zetterberg, Susan Baker, B Paul Morgan, Johannes Streffer, Pieter Jelle Visser, Lars Bertram, Simon Lovestone, Alejo J Nevado-Holgado
Alzheimer's & dementia : the journal of the Alzheimer's Association - 2019 -
Synaptic vesicle protein 2A as a potential biomarker in
synaptopathies.
Kerstin Heurling, Nicholas J. Ashton, Antoine Leuzy, Eduardo R Zimmer, Kaj Blennow, Henrik Zetterberg, Jonas Eriksson, Mark Lubberink, Michael Schöll
Molecular and cellular neurosciences - 2019 -
Biomarkers for tau
pathology.
Michael Schöll, Anne Maass, Niklas Mattsson, Nicholas J. Ashton, Kaj Blennow, Henrik Zetterberg, William Jagust
Molecular and cellular neurosciences - 2019 -
Primary fatty amides in plasma associated with brain amyloid burden, hippocampal volume, and memory in the European Medical Information Framework for Alzheimer's Disease biomarker discovery
cohort.
Min Kim, Stuart Snowden, Tommi Suvitaival, Ashfaq Ali, David J Merkler, Tahmina Ahmad, Sarah Westwood, Alison Baird, Petroula Proitsi, Alejo Nevado-Holgado, Abdul Hye, Isabelle Bos, Stephanie Vos, Rik Vandenberghe, Charlotte Teunissen, Mara Ten Kate, Philip Scheltens, Silvy Gabel, Karen Meersmans, Olivier Blin, Jill Richardson, Ellen De Roeck, Kristel Sleegers, Régis Bordet, Lorena Rami, Petronella Kettunen, Magda Tsolaki, Frans Verhey, Isabel Sala, Alberto Lléo, Gwendoline Peyratout, Mikel Tainta, Peter Johannsen, Yvonne Freund-Levi, Lutz Frölich, Valerija Dobricic, Sebastiaan Engelborghs, Giovanni B Frisoni, José L Molinuevo, Anders Wallin, Julius Popp, Pablo Martinez-Lage, Lars Bertram, Frederik Barkhof, Nicholas J. Ashton, Kaj Blennow, Henrik Zetterberg, Johannes Streffer, Pieter J Visser, Simon Lovestone, Cristina Legido-Quigley
Alzheimer's & dementia : the journal of the Alzheimer's Association - 2019 -
Plasma biomarkers for amyloid, tau, and cytokines in Down syndrome and sporadic Alzheimer's
disease
C. M. Startin, Nicholas J. Ashton, S. Hamburg, R. Hithersay, F. K. Wiseman, K. Y. Mok, J. Hardy, A. Lleo, S. Lovestone, L. Parnetti, Henrik Zetterberg, A. Hye, E. Fisher, D. Nizetic, J. Hardy, R. L. Weston, V. Tybulewicz, A. Karmiloff-Smith, A. Strydom, Ajmg V. P. Vani S
Alzheimers Research & Therapy - 2019 -
A plasma protein classifier for predicting amyloid burden for preclinical Alzheimer's
disease.
Nicholas J. Ashton, Alejo J Nevado-Holgado, Imelda S Barber, Steven Lynham, Veer Gupta, Pratishtha Chatterjee, Kathryn Goozee, Eugene Hone, Steve Pedrini, Kaj Blennow, Michael Schöll, Henrik Zetterberg, Kathryn A Ellis, Ashley I Bush, Christopher C Rowe, Victor L Villemagne, David Ames, Colin L Masters, Dag Aarsland, John Powell, Simon Lovestone, Ralph Martins, Abdul Hye
Science advances - 2019 -
Increased plasma neurofilament light chain concentration correlates with severity of post-mortem neurofibrillary tangle pathology and
neurodegeneration.
Nicholas J. Ashton, Antoine Leuzy, Yau Mun Lim, Claire Troakes, Tibor Hortobágyi, Kina Höglund, Dag Aarsland, Simon Lovestone, Michael Schöll, Kaj Blennow, Henrik Zetterberg, Abdul Hye
Acta neuropathologica communications - 2019 -
No association of salivary total tau concentration with Alzheimer's
disease.
Nicholas J. Ashton, Mark Ide, Michael Schöll, Kaj Blennow, Simon Lovestone, Abdul Hye, Henrik Zetterberg
Neurobiology of aging - 2018 -
In vivo Detection of Alzheimer's
Disease.
Antoine Leuzy, Kerstin Heurling, Nicholas J. Ashton, Michael Schöll, Eduardo R Zimmer
The Yale journal of biology and medicine - 2018 -
Plasma Protein Biomarkers for the Prediction of CSF Amyloid and Tau and F-18 -Flutemetamol PET Scan
Result
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Update on biomarkers for amyloid pathology in Alzheimer's
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