Nicholas Ashton
-
Apolipoprotein B is a novel marker for early tau pathology in Alzheimer's
disease
C. Picard, N. Nilsson, A. Labonte, D. Auld, P. Rosa-Neto, Nicholas J. Ashton, Henrik Zetterberg, Kaj Blennow, J. C. B. Breitner, S. Villeneuve, J. Poirier
Alzheimers & Dementia - 2021-01-01 -
Synaptic Molecular and Neurophysiological Markers Are Independent Predictors of Progression in Alzheimer's
Disease
U. Smailovic, I. Kareholt, T. Koenig, Nicholas J. Ashton, B. Winblad, K. Hoglund, P. Nilsson, Henrik Zetterberg, Kaj Blennow, V. Jelic
Journal of Alzheimers Disease - 2021-01-01 -
Microglial activation and tau propagate jointly across Braak
stages.
Tharick A Pascoal, Andrea L Benedet, Nicholas J. Ashton, Min Su Kang, Joseph Therriault, Mira Chamoun, Melissa Savard, Firoza Z Lussier, Cécile Tissot, Thomas Karikari, Julie Ottoy, Sulantha Mathotaarachchi, Jenna Stevenson, Gassan Massarweh, Michael Schöll, Mony J de Leon, Jean-Paul Soucy, Paul Edison, Kaj Blennow, Henrik Zetterberg, Serge Gauthier, Pedro Rosa-Neto
Nature medicine - 2021-01-01 -
Blood Biomarkers for Alzheimer's Disease in Down
Syndrome
Laia Montoliu-Gaya, A. Strydom, Kaj Blennow, Henrik Zetterberg, Nicholas J. Ashton
Journal of Clinical Medicine - 2021-01-01 -
Neurochemical signs of astrocytic and neuronal injury in acute COVID-19 normalizes during long-term
follow-up.
Nelly Kanberg, Joel Simrén, Arvid Edén, Lars-Magnus Andersson, Staffan Nilsson, Nicholas J. Ashton, Pär-Daniel Sundvall, Bengt Nellgård, Kaj Blennow, Henrik Zetterberg, Magnus Gisslén
EBioMedicine - 2021-01-01 -
A multicentre validation study of the diagnostic value of plasma neurofilament
light.
Nicholas J. Ashton, Shorena Janelidze, Ahmad Al Khleifat, Antoine Leuzy, Emma L van der Ende, Thomas Karikari, Andrea L Benedet, Tharick A Pascoal, Alberto Lleó, Lucilla Parnetti, Daniela Galimberti, Laura Bonanni, Andrea Pilotto, Alessandro Padovani, Jan Lycke, Lenka Novakova, Markus Axelsson, Latha Velayudhan, Gil D Rabinovici, Bruce Miller, Carmine Pariante, Naghmeh Nikkheslat, Susan M Resnick, Madhav Thambisetty, Michael Schöll, Gorka Fernández-Eulate, Francisco J Gil-Bea, Adolfo López de Munain, Ammar Al-Chalabi, Pedro Rosa-Neto, Andre Strydom, Per Svenningsson, Erik Stomrud, Alexander Santillo, Dag Aarsland, John C van Swieten, Sebastian Palmqvist, Henrik Zetterberg, Kaj Blennow, Abdul Hye, Oskar Hansson
Nature communications - 2021-01-01 -
Plasma NfL, clinical subtypes and motor progression in Parkinson's
disease
A. Pilotto, A. Imarisio, F. Conforti, A. Scalvini, S. Masciocchi, S. Nocivelli, R. Turrone, S. Gipponi, E. Cottini, B. Borroni, M. C. Rizzetti, M. Pizzi, L. Bonanni, A. Sturchio, A. J. Espay, Henrik Zetterberg, Nicholas J. Ashton, A. Hye, A. Padovani
Parkinsonism & Related Disorders - 2021-01-01 -
Comparison of Plasma Phosphorylated Tau Species With Amyloid and Tau Positron Emission Tomography, Neurodegeneration, Vascular Pathology, and Cognitive
Outcomes
M. M. Mielke, R. D. Frank, J. L. Dage, A. Jeromin, Nicholas J. Ashton, Kaj Blennow, Thomas Karikari, E. Vanmechelen, Henrik Zetterberg, A. Algeciras-Schimnich, D. S. Knopman, V. Lowe, G. J. Bu, P. Vemuri, J. Graff-Radford, C. R. Jack, R. C. Petersen
JAMA Neurology - 2021-01-01 -
Diagnostic and prognostic plasma biomarkers for preclinical Alzheimer's
disease.
Pratishtha Chatterjee, Steve Pedrini, Nicholas J. Ashton, Michelle Tegg, Kathryn Goozee, Abhay K Singh, Thomas Karikari, Joel Simrén, Eugeen Vanmechelen, Nicola J Armstrong, Eugene Hone, Prita R Asih, Kevin Taddei, Vincent Doré, Victor L Villemagne, Hamid R Sohrabi, Henrik Zetterberg, Colin L Masters, Kaj Blennow, Ralph N Martins
Alzheimer's & dementia : the journal of the Alzheimer's Association - 2021-01-01 -
Phosphorylated tau181 in plasma as a potential biomarker for Alzheimer's disease in adults with Down
syndrome
A. Lleo, Henrik Zetterberg, J. Pegueroles, Thomas Karikari, M. Carmona-Iragui, Nicholas J. Ashton, V. Montal, I. Barroeta, J. Lantero-Rodriguez, L. Videla, M. Altuna, B. Benejam, S. Fernandez, S. Valldeneu, D. Garzon, A. Bejanin, M. F. Iulita, V. Camacho, S. Medrano-Martorell, O. Belbin, J. Clarimon, S. Lehmann, D. Alcolea, R. Blesa, Kaj Blennow, J. Fortea
Nature Communications - 2021-01-01 -
Association of plasma P-tau181 with memory decline in non-demented
adults
J. Therriault, A. L. Benedet, T. A. Pascoal, F. Z. Lussier, C. Tissot, Thomas Karikari, Nicholas J. Ashton, M. Chamoun, G. Bezgin, S. Mathotaarachchi, S. Gauthier, P. Saha-Chaudhuri, Henrik Zetterberg, Kaj Blennow, P. Rosa-Neto
Brain Communications - 2021-01-01 -
Plasma levels of phosphorylated tau 181 are associated with cerebral metabolic dysfunction in cognitively impaired and amyloid-positive
individuals
F. Z. Lussier, A. L. Benedet, J. Therriault, T. A. Pascoal, C. Tissot, M. Chamoun, S. Mathotaarachchi, M. Savard, Nicholas J. Ashton, Thomas Karikari, Juan Rodriguez, Anniina Snellman, G. Bezgin, M. S. Kang, J. F. Arias, Y. T. Wang, S. Gauthier, Henrik Zetterberg, Kaj Blennow, P. Rosa-Neto
Brain Communications - 2021-01-01 -
Detecting amyloid positivity in early Alzheimer's disease using combinations of plasma A beta 42/A beta 40 and
p-tau
S. Janelidze, S. Palmqvist, A. Leuzy, E. Stomrud, I. M. W. Verberk, Henrik Zetterberg, Nicholas J. Ashton, P. Pesini, L. Sarasa, J. A. Allue, C. E. Teunissen, J. L. Dage, Kaj Blennow, N. Mattsson-Carlgren, O. Hansson
Alzheimers & Dementia - 2021-01-01 -
2020 update on the clinical validity of cerebrospinal fluid amyloid, tau, and phospho-tau as biomarkers for Alzheimer's disease in the context of a structured 5-phase development
framework
A. Leuzy, Nicholas J. Ashton, N. Mattsson-Carlgren, A. Dodich, M. Boccardi, J. Corre, A. Drzezga, A. Nordberg, R. Ossenkoppele, Henrik Zetterberg, Kaj Blennow, G. B. Frisoni, V. Garibotto, O. Hansson
European Journal of Nuclear Medicine and Molecular Imaging - 2021-01-01 -
The strategic biomarker roadmap for the validation of Alzheimer's diagnostic biomarkers: methodological
update
M. Boccardi, A. Dodich, E. Albanese, A. Gayet-Ageron, C. Festari, Nicholas J. Ashton, G. N. Bischof, K. Chiotis, A. Leuzy, E. E. Wolters, M. A. Walter, G. D. Rabinovici, M. Carrillo, A. Drzezga, O. Hansson, A. Nordberg, R. Ossenkoppele, V. L. Villemagne, B. Winblad, G. B. Frisoni, V. Garibotto
European Journal of Nuclear Medicine and Molecular Imaging - 2021-01-01 -
Critical illness polyneuropathy, myopathy and neuronal biomarkers in COVID-19 patients: A prospective
study
R. Frithiof, E. Rostami, E. Kumlien, J. Virhammar, D. Fallmar, M. Hultstrom, M. Lipcsey, Nicholas J. Ashton, Kaj Blennow, Henrik Zetterberg, A. R. Punga
Clinical Neurophysiology - 2021-01-01 -
Use of plasma biomarkers for AT(N) classification of neurodegenerative
dementias
D. Alcolea, C. Delaby, L. Muñoz, S. Torres, T. Estellés, N. Zhu, I. Barroeta, M. Carmona-Iragui, I. Illán-Gala, M. Á Santos-Santos, M. Altuna, I. Sala, Mª B. Sánchez-Saudinós, L. Videla, S. Valldeneu, A. Subirana, J. Pegueroles, C. Hirtz, J. Vialaret, S. Lehmann, Thomas Karikari, Nicholas J. Ashton, Kaj Blennow, Henrik Zetterberg, O. Belbin, R. Blesa, J. Clarimón, J. Fortea, A. Lleó
Journal of Neurology, Neurosurgery and Psychiatry - 2021-01-01 -
Proteomic blood profiling in mild, severe and critical COVID-19
patients
H. Patel, Nicholas J. Ashton, R. J. B. Dobson, Lars-Magnus Andersson, Aylin Yilmaz, Kaj Blennow, Magnus Gisslén, Henrik Zetterberg
Scientific Reports - 2021-01-01 -
Head-to-head comparison of amplified plasmonic exosome Aβ42 platform and single-molecule array immunoassay in a memory clinic
cohort.
Tomotaka Tanaka, Joyce Chong Ruifen, Ying-Hwey Nai, Chin Hong Tan, Carine Z J Lim, Yan Zhang, Mary C Stephenson, Saima Hilal, Francis N Saridin, Bibek Gyanwali, Steven Villaraza, Edward G Robins, Masafumi Ihara, Michael Schöll, Henrik Zetterberg, Kaj Blennow, Nicholas J. Ashton, Huilin Shao, Anthonin Reilhac, Christopher Chen
European journal of neurology - 2021-01-01 -
Time course of phosphorylated-tau181 in blood across the Alzheimer's disease
spectrum.
Alexis Moscoso Rial, Michel J. Grothe, Nicholas J. Ashton, Thomas Karikari, Juan Lantero Rodriguez, Anniina Snellman, Marc Suarez-Calvet, Henrik Zetterberg, Kaj Blennow, Michael Schöll
Brain : a journal of neurology - 2021-01-01 -
Head-to-head comparison of clinical performance of CSF phospho-tau T181 and T217 biomarkers for Alzheimer's disease
diagnosis.
Thomas Karikari, Agathe Vrillon, Juan Lantero Rodriguez, Nicholas J. Ashton, Milica Gregorič Kramberger, Julien Dumurgier, Claire Hourregue, Saša Čučnik, Gunnar Brinkmalm, Uroš Rot, Henrik Zetterberg, Claire Paquet, Kaj Blennow
Alzheimer's & dementia : the journal of the Alzheimer's Association - 2021-01-01 -
Complex Autoantibody Responses Occur following Moderate to Severe Traumatic Brain
Injury.
Edward J Needham, Oda Stoevesandt, Eric P Thelin, Henrik Zetterberg, Elisa R Zanier, Faiez Al Nimer, Nicholas J. Ashton, Joanne G Outtrim, Virginia F J Newcombe, Hani S Mousa, Joel Simrén, Kaj Blennow, Zhihui Yang, Peter J Hutchinson, Fredrik Piehl, Adel E Helmy, Mike J Taussig, Kevin K W Wang, Joanne L Jones, David K Menon, Alasdair J Coles
Journal of immunology (Baltimore, Md. : 1950) - 2021-01-01 -
Effects of pre-analytical procedures on blood biomarkers for Alzheimer's pathophysiology, glial activation, and
neurodegeneration.
Nicholas J. Ashton, Marc Suárez-Calvet, Thomas Karikari, Juan Lantero Rodriguez, Anniina Snellman, Joel Simrén, Carolina Minguillon, Karine Fauria, Kaj Blennow, Henrik Zetterberg
Alzheimer's & dementia (Amsterdam, Netherlands) - 2021-01-01 -
A genome-wide association study of plasma phosphorylated
tau181
Jodie Lord, Anna Zettergren, Nicholas J. Ashton, Thomas Karikari, Andréa Lessa Benedet, Joel Simrén, Abdul Hye, Dag Aarsland, Kaj Blennow, Henrik Zetterberg, Petroula Proitsi
Neurobiology of aging - 2021-01-01 -
Population-based blood screening for preclinical Alzheimer's disease in a British birth cohort at age
70.
Ashvini Keshavan, Josef Pannee, Thomas Karikari, Juan Rodriguez, Nicholas J. Ashton, Jennifer M Nicholas, David M Cash, William Coath, Christopher A Lane, Thomas D Parker, Kirsty Lu, Sarah M Buchanan, Sarah E Keuss, Sarah-Naomi James, Heidi Murray-Smith, Andrew Wong, Anna Barnes, John C Dickson, Amanda Heslegrave, Erik Portelius, Marcus Richards, Nick C Fox, Henrik Zetterberg, Kaj Blennow, Jonathan M Schott
Brain : a journal of neurology - 2021-01-01 -
Saliva Neurofilament Light Chain Is Not a Diagnostic Biomarker for Neurodegeneration in a Mixed Memory Clinic
Population
H. S. Gleerup, Federica Sanna, P. Hogh, Joel Simrén, Kaj Blennow, Henrik Zetterberg, S. G. Hasselbalch, Nicholas J. Ashton, A. H. Simonsen
Frontiers in Aging Neuroscience - 2021-01-01 -
Transitioning from cerebrospinal fluid to blood tests to facilitate diagnosis and disease monitoring in Alzheimer's
disease.
Deborah O T Alawode, Amanda J Heslegrave, Nicholas J. Ashton, Thomas Karikari, Joel Simrén, Laia Montoliu-Gaya, Josef Pannee, Antoinette O Connor, Philip S J Weston, Juan Lantero Rodriguez, Ashvini Keshavan, Anniina Snellman, Johan Gobom, Ross W Paterson, Jonathan M Schott, Kaj Blennow, Nick C Fox, Henrik Zetterberg
Journal of internal medicine - 2021-01-01 -
Cerebrospinal fluid biomarker panel for synaptic dysfunction in Alzheimer's
disease
Johanna Nilsson, Johan Gobom, Simon Sjödin, Gunnar Brinkmalm, Nicholas J. Ashton, Johan Svensson, Per Johansson, E. Portelius, Henrik Zetterberg, Kaj Blennow, Ann Brinkmalm
Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring - 2021-01-01 -
Plasma p-tau231: a new biomarker for incipient Alzheimer's disease
pathology.
Nicholas J. Ashton, Tharick A Pascoal, Thomas Karikari, Andréa Lessa Benedet, Juan Lantero Rodriguez, Gunnar Brinkmalm, Anniina Snellman, Michael Schöll, Claire Troakes, Abdul Hye, Serge Gauthier, Eugeen Vanmechelen, Henrik Zetterberg, Pedro Rosa-Neto, Kaj Blennow
Acta neuropathologica - 2021-01-01 -
Association between polygenic risk score of Alzheimer's disease and plasma phosphorylated tau in individuals from the Alzheimer's Disease Neuroimaging
Initiative.
Anna Zettergren, Jodie Lord, Nicholas J. Ashton, Andréa Lessa Benedet, Thomas Karikari, Juan Lantero Rodriguez, Anniina Snellman, Marc Suárez-Calvet, Petroula Proitsi, Henrik Zetterberg, Kaj Blennow
Alzheimer's research & therapy - 2021-01-01 -
Determining Amyloid-β Positivity Using 18F-AZD4694 PET
Imaging
J. Therriault, A. L. Benedet, T. A. Pascoal, M. Savard, Nicholas J. Ashton, M. Chamoun, C. Tissot, F. Lussier, M. S. Kang, G. Bezgin, T. Wang, J. Fernandes-Arias, G. Massarweh, P. Vitali, Henrik Zetterberg, Kaj Blennow, P. Saha-Chaudhuri, J. P. Soucy, S. Gauthier, P. Rosa-Neto
Journal of nuclear medicine : official publication, Society of Nuclear Medicine - 2021-01-01 -
The diagnostic and prognostic capabilities of plasma biomarkers in Alzheimer's
disease.
Joel Simrén, Antoine Leuzy, Thomas Karikari, Abdul Hye, Andréa Lessa Benedet, Juan Lantero Rodriguez, Niklas Mattsson-Carlgren, Michael Schöll, Patrizia Mecocci, Bruno Vellas, Magda Tsolaki, Iwona Kloszewska, Hilkka Soininen, Simon Lovestone, Dag Aarsland, Oskar Hansson, Pedro Rosa-Neto, Eric Westman, Kaj Blennow, Henrik Zetterberg, Nicholas J. Ashton
Alzheimer's & dementia : the journal of the Alzheimer's Association - 2021-01-01 -
Plasma neurofilament light chain as a potential biomarker in Charcot-Marie-Tooth
disease.
Elina Millere, Dmitrijs Rots, Joel Simrén, Nicholas J. Ashton, Einars Kupats, Ieva Micule, Viktorija Priedite, Natalja Kurjane, Kaj Blennow, Linda Gailite, Henrik Zetterberg, Viktorija Kenina
European journal of neurology - 2021-01-01 -
Plasma pTau181 predicts cortical brain atrophy in aging and Alzheimer's
disease.
Cécile Tissot, Andréa Lessa Benedet, Joseph Therriault, Tharick A Pascoal, Firoza Z Lussier, Paramita Saha-Chaudhuri, Mira Chamoun, Melissa Savard, Sulantha S Mathotaarachchi, Gleb Bezgin, Yi-Ting Wang, Jaime Fernandez Arias, Juan Rodriguez, Anniina Snellman, Nicholas J. Ashton, Thomas Karikari, Kaj Blennow, Henrik Zetterberg, Etienne De Villers-Sidani, Philippe Huot, Serge Gauthier, Pedro Rosa-Neto
Alzheimer's research & therapy - 2021-01-01 -
SARS-CoV-2 encephalitis is a cytokine release syndrome: evidences from cerebrospinal fluid
analyses.
Andrea Pilotto, Stefano Masciocchi, Irene Volonghi, Valeria De Giuli, Francesca Caprioli, Sara Mariotto, Sergio Ferrari, Silvia Bozzetti, Alberto Imarisio, Barbara Risi, Enrico Premi, Alberto Benussi, Emanuele Focà, Francesco Castelli, Gianluigi Zanusso, Salvatore Monaco, Paola Stefanelli, Roberto Gasparotti, Anastasia Zekeridou, Andrew McKeon, Nicholas J. Ashton, Kaj Blennow, Henrik Zetterberg, Alessandro Padovani
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America - 2021-01-01 -
Plasma P-tau181 to Aβ42 ratio is associated with brain amyloid burden and hippocampal atrophy in an Asian cohort of Alzheimer's disease patients with concomitant cerebrovascular
disease.
Joyce R Chong, Nicholas J. Ashton, Thomas Karikari, Tomotaka Tanaka, Francis N Saridin, Anthonin Reilhac, Edward G Robins, Ying-Hwey Nai, Henri Vrooman, Saima Hilal, Henrik Zetterberg, Kaj Blennow, Mitchell K P Lai, Christopher P Chen
Alzheimer's & dementia : the journal of the Alzheimer's Association - 2021-01-01 -
Longitudinal Associations of Blood Phosphorylated Tau181 and Neurofilament Light Chain With Neurodegeneration in Alzheimer
Disease.
Alexis Moscoso Rial, Michel J. Grothe, Nicholas J. Ashton, Thomas Karikari, Juan Lantero Rodriguez, Anniina Snellman, Marc Suárez-Calvet, Kaj Blennow, Henrik Zetterberg, Michael Schöll
JAMA Neurology - 2021-01-01 -
The validation status of blood biomarkers of amyloid and phospho-tau assessed with the 5-phase development framework for AD
biomarkers
Nicholas J. Ashton, A. Leuzy, Thomas Karikari, N. Mattsson-Carlgren, A. Dodich, M. Boccardi, J. Corre, A. Drzezga, A. Nordberg, R. Ossenkoppele, Henrik Zetterberg, Kaj Blennow, G. B. Frisoni, V. Garibotto, O. Hansson
European Journal of Nuclear Medicine and Molecular Imaging - 2021-01-01 -
Blood neurofilament light in remote settings: Alternative protocols to support sample collection in challenging pre-analytical
conditions.
Joel Simrén, Nicholas J. Ashton, Kaj Blennow, Henrik Zetterberg
Alzheimer's & dementia (Amsterdam, Netherlands) - 2021-01-01 -
Diagnostic performance and prediction of clinical progression of plasma phospho-tau181 in the Alzheimer's Disease Neuroimaging
Initiative.
Thomas Karikari, Andréa L Benedet, Nicholas J. Ashton, Juan Lantero Rodriguez, Anniina Snellman, Marc Suárez-Calvet, Paramita Saha-Chaudhuri, Firoza Lussier, Hlin Kvartsberg, Alexis Moscoso Rial, Tharick A Pascoal, Ulf Andreasson, Michael Schöll, Michael W Weiner, Pedro Rosa-Neto, John Q Trojanowski, Leslie M Shaw, Kaj Blennow, Henrik Zetterberg
Molecular psychiatry - 2021-01-01 -
Biomarkers for central nervous system injury in cerebrospinal fluid are elevated in COVID-19 and associated with neurological symptoms and disease
severity
J. Virhammar, A. Naas, D. Fallmar, J. L. Cunningham, A. Klang, Nicholas J. Ashton, S. Jackmann, G. Westman, R. Frithiof, Kaj Blennow, Henrik Zetterberg, E. Kumlien, E. Rostami
European Journal of Neurology - 2021-01-01 -
Neurofilament light as an outcome predictor after cardiac arrest: a post hoc analysis of the COMACARE
trial
L. Wihersaari, Nicholas J. Ashton, M. Reinikainen, P. Jakkula, V. Pettila, J. Hastbacka, M. Tiainen, P. Loisa, H. Friberg, T. Cronberg, Kaj Blennow, Henrik Zetterberg, M. B. Skrifvars
Intensive Care Medicine - 2021-01-01 -
Diagnostic and prognostic value of serum NfL and p-Tau181 in frontotemporal lobar
degeneration.
Alberto Benussi, Thomas Karikari, Nicholas J. Ashton, Stefano Gazzina, Enrico Premi, Luisa Benussi, Roberta Ghidoni, Juan Lantero Rodriguez, Andreja Emersic, Joel Simrén, Giuliano Binetti, Silvia Fostinelli, Marcello Giunta, Roberto Gasparotti, Henrik Zetterberg, Kaj Blennow, Barbara Borroni
Journal of neurology, neurosurgery, and psychiatry - 2020-01-01 -
Dickkopf-1 Overexpression in vitro Nominates Candidate Blood Biomarkers Relating to Alzheimer's Disease
Pathology.
Liu Shi, Laura M Winchester, Benjamine Y Liu, Richard Killick, Elena M Ribe, Sarah Westwood, Alison L Baird, Noel J Buckley, Shengjun Hong, Valerija Dobricic, Fabian Kilpert, Andre Franke, Steven Kiddle, Martina Sattlecker, Richard Dobson, Antonio Cuadrado, Abdul Hye, Nicholas J. Ashton, Angharad R Morgan, Isabelle Bos, Stephanie J B Vos, Mara Ten Kate, Philip Scheltens, Rik Vandenberghe, Silvy Gabel, Karen Meersmans, Sebastiaan Engelborghs, Ellen E De Roeck, Kristel Sleegers, Giovanni B Frisoni, Olivier Blin, Jill C Richardson, Régis Bordet, José L Molinuevo, Lorena Rami, Anders Wallin, Petronella Kettunen, Magda Tsolaki, Frans Verhey, Alberto Lleó, Daniel Alcolea, Julius Popp, Gwendoline Peyratout, Pablo Martinez-Lage, Mikel Tainta, Peter Johannsen, Charlotte E Teunissen, Yvonne Freund-Levi, Lutz Frölich, Cristina Legido-Quigley, Frederik Barkhof, Kaj Blennow, Katrine Laura Rasmussen, Børge Grønne Nordestgaard, Ruth Frikke-Schmidt, Sune Fallgaard Nielsen, Hilkka Soininen, Bruno Vellas, Iwona Kloszewska, Patrizia Mecocci, Henrik Zetterberg, B Paul Morgan, Johannes Streffer, Pieter Jelle Visser, Lars Bertram, Alejo J Nevado-Holgado, Simon Lovestone
Journal of Alzheimer's disease : JAD - 2020-01-01 -
Serum Glial Fibrillary Acidic Protein (GFAP) Is a Marker of Disease Severity in Frontotemporal Lobar
Degeneration.
Alberto Benussi, Nicholas J. Ashton, Thomas Karikari, Stefano Gazzina, Enrico Premi, Luisa Benussi, Roberta Ghidoni, Juan Lantero Rodriguez, Andreja Emersic, Giuliano Binetti, Silvia Fostinelli, Marcello Giunta, Roberto Gasparotti, Henrik Zetterberg, Kaj Blennow, Barbara Borroni
Journal of Alzheimer's disease : JAD - 2020-01-01 -
Stage-specific links between plasma neurofilament light and imaging biomarkers of Alzheimer's
disease.
Andréa Lessa Benedet, Antoine Leuzy, Nicholas J. Ashton, Sulantha Mathotaarachchi, Melissa Savard, Joseph Therriault, Min Su Kang, Mira Chamoun, Michael Schöll, Eduardo R Zimmer, Serge Gauthier, Aurélie Labbe, Henrik Zetterberg, Pedro Rosa-Neto, Kaj Blennow
Brain : a journal of neurology - 2020-01-01 -
Urinary metabolic phenotyping for Alzheimer's
disease
N. Kurbatova, M. Garg, L. Whiley, E. Chekmeneva, B. Jimenez, M. Gomez-Romero, J. Pearce, T. Kimhofer, E. D'Hondt, H. Soininen, I. Kloszewska, P. Mecocci, M. Tsolaki, B. Vellas, D. Aarsland, A. Nevado-Holgado, B. Liu, S. Snowden, P. Proitsi, Nicholas J. Ashton, A. Hye, C. Legido-Quigley, M. R. Lewis, J. K. Nicholson, E. Holmes, A. Brazma, S. Lovestone
Scientific Reports - 2020-01-01 -
Blood phosphorylated tau 181 as a biomarker for Alzheimer's disease: a diagnostic performance and prediction modelling study using data from four prospective
cohorts.
Thomas Karikari, Tharick A Pascoal, Nicholas J. Ashton, Shorena Janelidze, Andréa Lessa Benedet, Juan Lantero Rodriguez, Mira Chamoun, Melissa Savard, Min Su Kang, Joseph Therriault, Michael Schöll, Gassan Massarweh, Jean-Paul Soucy, Kina Höglund, Gunnar Brinkmalm, Niklas Mattsson, Sebastian Palmqvist, Serge Gauthier, Erik Stomrud, Henrik Zetterberg, Oskar Hansson, Pedro Rosa-Neto, Kaj Blennow
The Lancet. Neurology - 2020-01-01 -
Comparing Glial Fibrillary Acidic Protein (GFAP) in Serum and Plasma Following Mild Traumatic Brain Injury in Older
Adults.
Nathan A Huebschmann, Teemu M Luoto, Justin E Karr, Ksenia Berghem, Kaj Blennow, Henrik Zetterberg, Nicholas J. Ashton, Joel Simrén, Jussi P Posti, Jessica M Gill, Grant L Iverson
Frontiers in neurology - 2020-01-01 -
Novel tau biomarkers phosphorylated at T181, T217 or T231 rise in the initial stages of the preclinical Alzheimer's continuum when only subtle changes in Aβ pathology are
detected.
Marc Suárez-Calvet, Thomas Karikari, Nicholas J. Ashton, Juan Lantero Rodriguez, Marta Milà-Alomà, Juan Domingo Gispert, Gemma Salvadó, Carolina Minguillon, Karine Fauria, Mahnaz Shekari, Oriol Grau-Rivera, Eider M Arenaza-Urquijo, Aleix Sala-Vila, Gonzalo Sánchez-Benavides, José Maria González-de-Echávarri, Gwendlyn Kollmorgen, Erik Stoops, Eugeen Vanmechelen, Henrik Zetterberg, Kaj Blennow, José Luis Molinuevo
EMBO molecular medicine - 2020-01-01 -
Full-length and C-terminal neurogranin in Alzheimer's disease cerebrospinal fluid analyzed by novel ultrasensitive
immunoassays
Annika Öhrfelt, J. Dumurgier, Henrik Zetterberg, A. Vrillon, Nicholas J. Ashton, Hlin Kvartsberg, E. Bouaziz-Amar, J. Hugon, C. Paquet, Kaj Blennow
Alzheimers Research & Therapy - 2020-01-01 -
Neurochemical evidence of astrocytic and neuronal injury commonly found in
COVID-19.
Nelly Kanberg, Nicholas J. Ashton, Lars-Magnus Andersson, Aylin Yilmaz, Magnus Lindh, Staffan Nilsson, Richard W Price, Kaj Blennow, Henrik Zetterberg, Magnus Gisslén
Neurology - 2020-01-01 -
Steroid-Responsive Encephalitis in Coronavirus Disease
2019
A. Pilotto, S. Odolini, S. Masciocchi, A. Comelli, I. Volonghi, S. Gazzina, S. Nocivelli, A. Pezzini, E. Foca, A. Caruso, M. Leonardi, M. P. Pasolini, R. Gasparotti, F. Castelli, Nicholas J. Ashton, Kaj Blennow, Henrik Zetterberg, A. Padovani
Annals of Neurology - 2020-01-01 -
Fluid Biomarkers for Synaptic Dysfunction and
Loss
Elena Camporesi, Johanna Nilsson, Ann Brinkmalm, Bruno Becker, Nicholas J. Ashton, Kaj Blennow, Henrik Zetterberg
Biomarker Insights - 2020-01-01 -
Relevance of biomarkers across different
neurodegenerative.
Alexander J Ehrenberg, Ayesha Khatun, Emma Coomans, Matthew J Betts, Federica Capraro, Elisabeth H Thijssen, Konstantin Senkevich, Tehmina Bharucha, Mehrsa Jafarpour, Peter N E Young, William Jagust, Stephen F Carter, Tammaryn Lashley, Lea T Grinberg, Joana B Pereira, Niklas Mattsson-Carlgren, Nicholas J. Ashton, Jörg Hanrieder, Henrik Zetterberg, Michael Schöll, Ross W Paterson
Alzheimer's research & therapy - 2020-01-01 -
Plasma p-tau181 accurately predicts Alzheimer's disease pathology at least 8 years prior to post-mortem and improves the clinical characterisation of cognitive
decline.
Juan Lantero Rodriguez, Thomas Karikari, Marc Suárez-Calvet, Claire Troakes, Andrew King, Andreja Emersic, Dag Aarsland, Abdul Hye, Henrik Zetterberg, Kaj Blennow, Nicholas J. Ashton
Acta neuropathologica - 2020-01-01 -
Plasma phospho-tau181 in presymptomatic and symptomatic familial Alzheimer's disease: a longitudinal cohort
study
A. O'Connor, Thomas Karikari, T. Poole, Nicholas J. Ashton, Juan Rodriguez, A. Khatun, I. Swift, A. J. Heslegrave, E. Abel, E. Chung, P. S. J. Weston, I. M. Pavisic, N. S. Ryan, S. Barker, M. N. Rossor, J. M. Polke, C. Frost, S. Mead, Kaj Blennow, Henrik Zetterberg, N. C. Fox
Molecular Psychiatry - 2020-01-01 -
Serum Hepcidin Levels in Cognitively Normal Older Adults with High Neocortical Amyloid-beta
Load
P. Chatterjee, M. Mohammadi, K. Goozee, T. M. Shah, H. R. Sohrabi, C. B. Dias, K. K. Shen, P. R. Asih, P. Dave, S. Pedrini, Nicholas J. Ashton, A. Hye, K. Taddei, D. B. Lovejoy, Henrik Zetterberg, Kaj Blennow, R. N. Martins
Journal of Alzheimers Disease - 2020-01-01 -
Plasma transferrin and hemopexin are associated with altered A beta uptake and cognitive decline in Alzheimer's disease
pathology
A. Ashraf, Nicholas J. Ashton, P. Chatterjee, K. Goozee, K. K. Shen, J. Fripp, D. Ames, C. Rowe, C. L. Masters, V. Villemagne, A. Hye, R. N. Martins, P. W. So
Alzheimers Research & Therapy - 2020-01-01 -
An update on fluid biomarkers for neurodegenerative diseases: recent success and challenges
ahead.
Joel Simrén, Nicholas J. Ashton, Kaj Blennow, Henrik Zetterberg
Current opinion in neurobiology - 2020-01-01 -
Propagation of Tau Pathology: Integrating Insights From Postmortem and In Vivo
Studies.
Thomas Vogels, Antoine Leuzy, Claudia Cicognola, Nicholas J. Ashton, Tomas Smolek, Michal Novak, Kaj Blennow, Henrik Zetterberg, Tomas Hromadka, Norbert Zilka, Michael Schöll
Biological psychiatry - 2020-01-01 -
Perspectives in fluid biomarkers in neurodegeneration from the 2019 biomarkers in neurodegenerative diseases course-a joint PhD student course at University College London and University of
Gothenburg.
Pawel Obrocki, Ayesha Khatun, Deborah Ness, Konstantin Senkevich, Jörg Hanrieder, Federica Capraro, Niklas Mattsson, Ulf Andreasson, Erik Portelius, Nicholas J. Ashton, Kaj Blennow, Michael Schöll, Ross W Paterson, Jonathan M Schott, Henrik Zetterberg
Alzheimer's research & therapy - 2020-01-01 -
Validation of Plasma Proteomic Biomarkers Relating to Brain Amyloid Burden in the EMIF-Alzheimer's Disease Multimodal Biomarker Discovery
Cohort.
Sarah Westwood, Alison L Baird, Sneha N Anand, Alejo J Nevado-Holgado, Andrey Kormilitzin, Liu Shi, Abdul Hye, Nicholas J. Ashton, Angharad R Morgan, Isabelle Bos, Stephanie J B Vos, Susan Baker, Noel J Buckley, Mara Ten Kate, Philip Scheltens, Charlotte E Teunissen, Rik Vandenberghe, Silvy Gabel, Karen Meersmans, Sebastiaan Engelborghs, Ellen E De Roeck, Kristel Sleegers, Giovanni B Frisoni, Olivier Blin, Jill C Richardson, Régis Bordet, José L Molinuevo, Lorena Rami, Anders Wallin, Petronella Kettunen, Magda Tsolaki, Frans Verhey, Alberto Lléo, Isabel Sala, Julius Popp, Gwendoline Peyratout, Pablo Martinez-Lage, Mikel Tainta, Peter Johannsen, Yvonne Freund-Levi, Lutz Frölich, Valerija Dobricic, Cristina Legido-Quigley, Lars Bertram, Frederik Barkhof, Henrik Zetterberg, B Paul Morgan, Johannes Streffer, Pieter Jelle Visser, Simon Lovestone
Journal of Alzheimer's disease : JAD - 2020-01-01 -
An update on blood-based biomarkers for non-Alzheimer neurodegenerative
disorders.
Nicholas J. Ashton, Abdul Hye, Anto P Rajkumar, Antoine Leuzy, Stuart Snowden, Marc Suárez-Calvet, Thomas Karikari, Michael Schöll, Renaud La Joie, Gil D Rabinovici, Kina Höglund, Clive Ballard, Tibor Hortobágyi, Per Svenningsson, Kaj Blennow, Henrik Zetterberg, Dag Aarsland
Nature Reviews Neurology - 2020-01-01 -
Comparative analysis of obesity-related cardiometabolic and renal biomarkers in human plasma and
serum.
Meenu Rohin Rajan, Matus Sotak, Fredrik Barrenäs, Tong Shen, Kamil Borkowski, Nicholas J. Ashton, Christina Biörserud, Tomas L Lindahl, Sofia Ramström, Michael Schöll, Per Lindahl, Oliver Fiehn, John W Newman, Rosie Perkins, Ville Wallenius, Stephan Lange, Emma Börgeson
Scientific reports - 2019-01-01 -
Salivary Biomarkers for Alzheimer's Disease and Related
Disorders.
Nicholas J. Ashton, Mark Ide, Henrik Zetterberg, Kaj Blennow
Neurology and therapy - 2019-01-01 -
Plasma levels of soluble TREM2 and neurofilament light chain in TREM2 rare variant
carriers.
Nicholas J. Ashton, Marc Suarez-Calvet, Amanda Heslegrave, Abdul Hye, Cristina Razquin, Pau Pastor, Raquel Sanchez-Valle, José L Molinuevo, Pieter Jelle Visser, Kaj Blennow, Angela K Hodges, Henrik Zetterberg
Alzheimer's research & therapy - 2019-01-01 -
Plasma neurofilament light chain and amyloid-β are associated with the kynurenine pathway metabolites in preclinical Alzheimer's
disease.
Pratishtha Chatterjee, Henrik Zetterberg, Kathryn Goozee, Chai K Lim, Kelly R Jacobs, Nicholas J. Ashton, Abdul Hye, Steve Pedrini, Hamid R Sohrabi, Tejal Shah, Prita R Asih, Preeti Dave, Kaikai Shen, Kevin Taddei, David B Lovejoy, Gilles J Guillemin, Kaj Blennow, Ralph N Martins
Journal of neuroinflammation - 2019-01-01 -
Discovery and validation of plasma proteomic biomarkers relating to brain amyloid burden by SOMAscan
assay.
Liu Shi, Sarah Westwood, Alison L Baird, Laura Winchester, Valerija Dobricic, Fabian Kilpert, Shengjun Hong, Andre Franke, Abdul Hye, Nicholas J. Ashton, Angharad R Morgan, Isabelle Bos, Stephanie J B Vos, Noel J Buckley, Mara Ten Kate, Philip Scheltens, Rik Vandenberghe, Silvy Gabel, Karen Meersmans, Sebastiaan Engelborghs, Ellen E De Roeck, Kristel Sleegers, Giovanni B Frisoni, Olivier Blin, Jill C Richardson, Régis Bordet, José L Molinuevo, Lorena Rami, Anders Wallin, Petronella Kettunen, Magda Tsolaki, Frans Verhey, Alberto Lleó, Daniel Alcolea, Julius Popp, Gwendoline Peyratout, Pablo Martinez-Lage, Mikel Tainta, Peter Johannsen, Charlotte E Teunissen, Yvonne Freund-Levi, Lutz Frölich, Cristina Legido-Quigley, Frederik Barkhof, Kaj Blennow, Henrik Zetterberg, Susan Baker, B Paul Morgan, Johannes Streffer, Pieter Jelle Visser, Lars Bertram, Simon Lovestone, Alejo J Nevado-Holgado
Alzheimer's & dementia : the journal of the Alzheimer's Association - 2019-01-01 -
Synaptic vesicle protein 2A as a potential biomarker in
synaptopathies.
Kerstin Heurling, Nicholas J. Ashton, Antoine Leuzy, Eduardo R Zimmer, Kaj Blennow, Henrik Zetterberg, Jonas Eriksson, Mark Lubberink, Michael Schöll
Molecular and cellular neurosciences - 2019-01-01 -
Plasma neurofilament light associates with Alzheimer's disease metabolic decline in amyloid-positive
individuals.
Andréa L Benedet, Nicholas J. Ashton, Tharick A Pascoal, Antoine Leuzy, Sulantha Mathotaarachchi, Min S Kang, Joseph Therriault, Melissa Savard, Mira Chamoun, Michael Schöll, Eduardo R Zimmer, Serge Gauthier, Aurélie Labbe, Henrik Zetterberg, Kaj Blennow, Pedro R Neto
Alzheimer's & dementia - 2019-01-01 -
Biomarkers for tau
pathology.
Michael Schöll, Anne Maass, Niklas Mattsson, Nicholas J. Ashton, Kaj Blennow, Henrik Zetterberg, William Jagust
Molecular and cellular neurosciences - 2019-01-01 -
Primary fatty amides in plasma associated with brain amyloid burden, hippocampal volume, and memory in the European Medical Information Framework for Alzheimer's Disease biomarker discovery
cohort.
Min Kim, Stuart Snowden, Tommi Suvitaival, Ashfaq Ali, David J Merkler, Tahmina Ahmad, Sarah Westwood, Alison Baird, Petroula Proitsi, Alejo Nevado-Holgado, Abdul Hye, Isabelle Bos, Stephanie Vos, Rik Vandenberghe, Charlotte Teunissen, Mara Ten Kate, Philip Scheltens, Silvy Gabel, Karen Meersmans, Olivier Blin, Jill Richardson, Ellen De Roeck, Kristel Sleegers, Régis Bordet, Lorena Rami, Petronella Kettunen, Magda Tsolaki, Frans Verhey, Isabel Sala, Alberto Lléo, Gwendoline Peyratout, Mikel Tainta, Peter Johannsen, Yvonne Freund-Levi, Lutz Frölich, Valerija Dobricic, Sebastiaan Engelborghs, Giovanni B Frisoni, José L Molinuevo, Anders Wallin, Julius Popp, Pablo Martinez-Lage, Lars Bertram, Frederik Barkhof, Nicholas J. Ashton, Kaj Blennow, Henrik Zetterberg, Johannes Streffer, Pieter J Visser, Simon Lovestone, Cristina Legido-Quigley
Alzheimer's & dementia : the journal of the Alzheimer's Association - 2019-01-01 -
Plasma biomarkers for amyloid, tau, and cytokines in Down syndrome and sporadic Alzheimer's
disease
C. M. Startin, Nicholas J. Ashton, S. Hamburg, R. Hithersay, F. K. Wiseman, K. Y. Mok, J. Hardy, A. Lleo, S. Lovestone, L. Parnetti, Henrik Zetterberg, A. Hye, E. Fisher, D. Nizetic, J. Hardy, R. L. Weston, V. Tybulewicz, A. Karmiloff-Smith, A. Strydom, Ajmg V. P. Vani S
Alzheimers Research & Therapy - 2019-01-01 -
A plasma protein classifier for predicting amyloid burden for preclinical Alzheimer's
disease.
Nicholas J. Ashton, Alejo J Nevado-Holgado, Imelda S Barber, Steven Lynham, Veer Gupta, Pratishtha Chatterjee, Kathryn Goozee, Eugene Hone, Steve Pedrini, Kaj Blennow, Michael Schöll, Henrik Zetterberg, Kathryn A Ellis, Ashley I Bush, Christopher C Rowe, Victor L Villemagne, David Ames, Colin L Masters, Dag Aarsland, John Powell, Simon Lovestone, Ralph Martins, Abdul Hye
Science advances - 2019-01-01 -
Increased plasma neurofilament light chain concentration correlates with severity of post-mortem neurofibrillary tangle pathology and
neurodegeneration.
Nicholas J. Ashton, Antoine Leuzy, Yau Mun Lim, Claire Troakes, Tibor Hortobágyi, Kina Höglund, Dag Aarsland, Simon Lovestone, Michael Schöll, Kaj Blennow, Henrik Zetterberg, Abdul Hye
Acta neuropathologica communications - 2019-01-01 -
No association of salivary total tau concentration with Alzheimer's
disease.
Nicholas J. Ashton, Mark Ide, Michael Schöll, Kaj Blennow, Simon Lovestone, Abdul Hye, Henrik Zetterberg
Neurobiology of aging - 2018-01-01 -
In vivo Detection of Alzheimer's
Disease.
Antoine Leuzy, Kerstin Heurling, Nicholas J. Ashton, Michael Schöll, Eduardo R Zimmer
The Yale journal of biology and medicine - 2018-01-01 -
Plasma Protein Biomarkers for the Prediction of CSF Amyloid and Tau and F-18 -Flutemetamol PET Scan
Result
S. Westwood, A. L. Baird, A. Hye, Nicholas J. Ashton, A. J. Nevado-Holgado, S. N. Anand, B. Liu, D. Newby, C. Bazenet, S. J. Kiddle, M. Ward, B. Newton, K. Desai, C. T. Hehir, M. Zanette, D. Galimberti, L. Parnetti, A. Lleo, S. Baker, V. A. Narayan, W. M. van der Flier, P. Scheltens, C. E. Teunissen, P. J. Visser, S. Lovestone
Frontiers in Aging Neuroscience - 2018-01-01 -
Update on biomarkers for amyloid pathology in Alzheimer's
disease
Nicholas J. Ashton, Michael Schöll, Kerstin Heurling, Eleni Gkanatsiou, Erik Portelius, Kina Höglund, Gunnar Brinkmalm, A Hye, Kaj Blennow, Henrik Zetterberg
Biomarkers in medicine - 2018-01-01