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Fredrik Bäckhed
Professor
Department of Molecular and ClinicalAbout Fredrik Bäckhed
About the research group - Bäckhed Lab
To full list of publications: ORCID: 0000-0002-4871-8818
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Moderate variations in the human diet impact the gut microbiota in humanized
mice
Marc Schöler, Rima Chakaroun, Harald Brolin, Ingrid Larsson, Rosie Perkins, Hanns-Ulrich Marschall, Robert Caesar, Fredrik Bäckhed
ACTA PHYSIOLOGICA - 2024 -
Prognostic value of gut microbe-generated metabolite phenylacetylglutamine in patients with heart
failure
W. H. Wilson Tang, Ina Nemet, Xinmin S. Li, Yuping Wu, Arash Haghikia, Marco Witkowski, Robert A. Koeth, Ilja Demuth, Maximilian Koenig, Elisabeth Steinhagen-Thiessen, Fredrik Bäckhed, Michael A. Fischbach, Arjun Deb, Ulf Landmesser, Stanley L. Hazen
EUROPEAN JOURNAL OF HEART FAILURE - 2024 -
6 alpha-hydroxylated bile acids mediate TGR5 signalling to improve glucose metabolism upon dietary fiber supplementation in
mice
Kassem Makki, Harald Brolin, N. Petersen, Marcus Henricsson, D. P. Christensen, Muhammad Tanweer Khan, Annika Wahlström, Per-Olof Bergh, Valentina Tremaroli, K. Schoonjans, Hanns-Ulrich Marschall, Fredrik Bäckhed
Gut - 2023 -
The potential of tailoring the gut microbiome to prevent and treat cardiometabolic
disease
Rima Chakaroun, Lisa M. Olsson, Fredrik Bäckhed
Nature Reviews Cardiology - 2023 -
Muc2-dependent microbial colonization of the jejunal mucus layer is diet sensitive and confers local resistance to enteric pathogen
infection
George M. H. Birchenough, Björn O. Schröder, Sinan Sharba, Liisa Arike, Christian V Recktenwald, F. Puertolas-Balint, Mahadevan Subramani, Karl Hansson, B. Yilmaz, Sara K. Lindén, Fredrik Bäckhed, Gunnar C. Hansson
Cell Reports - 2023 -
Evidence of a causal and modifiable relationship between kidney function and circulating trimethylamine
<i>N</i>-oxide
P. Andrikopoulos, J. Aron-Wisnewsky, Rima Chakaroun, A. Myridakis, S. K. Forslund, T. Nielsen, S. Adriouch, B. Holmes, J. Chilloux, S. Vieira-Silva, G. Falony, J. E. Salem, F. Andreelli, E. Belda, J. Kieswich, K. Chechi, F. Puig-Castellvi, M. Chevalier, E. Le Chatelier, M. T. Olanipekun, L. Hoyles, R. Alves, G. Helft, R. Isnard, L. Kober, L. P. Coelho, C. Rouault, D. Gauguier, J. P. Gotze, E. Prifti, P. Froguel, J. D. Zucker, Fredrik Bäckhed, H. Vestergaard, T. Hansen, J. M. Oppert, M. Blüher, J. Nielsen, J. Raes, P. Bork, M. M. Yaqoob, M. Stumvoll, O. Pedersen, S. D. Ehrlich, K. Clément, M. E. Dumas, Consortium MetaCardis
Nature Communications - 2023 -
Microbial dietary protein metabolism regulates GLP-1 mediated intestinal
transit
P. B. Toft, H. Yashiro, D. M. Erion, M. P. Gillum, Fredrik Bäckhed, T. Arora
Faseb Journal - 2023 -
Synergy and oxygen adaptation for development of next-generation
probiotics
Muhammad Tanweer Khan, Chinmay Dwibedi, Daniel Sundh, Meenakshi Pradhan, Jamie D. Kraft, Robert Caesar, Valentina Tremaroli, Mattias Lorentzon, Fredrik Bäckhed
Nature - 2023 -
Microbial metabolite p-cresol inhibits gut hormone expression and regulates small intestinal transit in
mice
P. B. Toft, A. M. Vanslette, K. Trost, T. Moritz, M. P. Gillum, Fredrik Bäckhed, T. Arora
FRONTIERS IN ENDOCRINOLOGY - 2023 -
Absence of gut microbiota reduces neonatal survival and exacerbates liver disease in Cyp2c70-deficient mice with a human-like bile acid
composition
Wilhelm Sjöland, Annika Wahlström, Kassem Makki, Marc Schöler, Antonio Molinaro, Lisa M. Olsson, Thomas U. Greiner, Robert Caesar, J. F. de Boer, F. Kuipers, Fredrik Bäckhed, Hanns-Ulrich Marschall
Clinical Science - 2023 -
The gut microbiota contributes to the pathogenesis of anorexia nervosa in humans and
mice
Y. Fan, R. K. Stoving, S. B. Ibraim, T. Hyotylainen, F. Thirion, T. Arora, L. Lyu, E. Stankevic, T. H. Hansen, P. Dechelotte, T. Sinioja, O. Ragnarsdottir, N. Pons, N. Galleron, B. Quinquis, F. Levenez, H. Roume, G. Falony, S. Vieira-Silva, J. Raes, L. Clausen, G. K. Telleus, Fredrik Bäckhed, M. Oresic, S. D. Ehrlich, O. Pedersen
Nature Microbiology - 2023 -
Questioning the fetal microbiome illustrates pitfalls of low-biomass microbial
studies
K. M. Kennedy, M. C. de Goffau, M. E. Perez-Munoz, M. C. Arrieta, Fredrik Bäckhed, P. Bork, T. Braun, F. D. Bushman, J. Dore, W. M. de Vos, A. M. Earl, J. A. Eisen, M. A. Elovitz, S. C. Ganal-Vonarburg, M. G. Ganzle, W. S. Garrett, L. J. Hall, M. W. Hornef, C. Huttenhower, L. Konnikova, S. Lebeer, A. J. Macpherson, R. C. Massey, A. C. McHardy, O. Koren, T. D. Lawley, R. E. Ley, L. O'Mahony, P. W. O'Toole, E. G. Pamer, J. Parkhill, J. Raes, T. Rattei, A. Salonen, E. Segal, N. Segata, F. Shanahan, D. M. Sloboda, G. C. S. Smith, H. Sokol, T. D. Spector, M. G. Surette, G. W. Tannock, A. W. Walker, M. Yassour, J. Walter
Nature - 2023 -
Gut Microbiota-Generated Phenylacetylglutamine and Heart
Failure
K. A. Romano, I. Nemet, P. P. Saha, A. Haghikia, X. M. S. Li, M. L. Mohan, B. Lovano, L. Castel, M. Witkowski, J. A. Buffa, Y. Sun, L. Li, C. M. Menge, I. Demuth, M. Konig, E. Steinhagen-Thiessen, J. A. DiDonato, A. Deb, Fredrik Bäckhed, W. H. W. Tang, S. V. N. Prasad, U. Landmesser, D. R. Van Wagoner, S. L. Hazen
Circulation-Heart Failure - 2023 -
Microbially Produced Imidazole Propionate Is Associated With Heart Failure and
Mortality.
Antonio Molinaro, Ina Nemet, Pierre Bel Lassen, Rima Chakaroun, Trine Nielsen, Judith Aron-Wisnewsky, Per-Olof Bergh, Lin Li, Marcus Henricsson, Lars Køber, Richard Isnard, Gerard Helft, Michael Stumvoll, Oluf Pedersen, J. Gustav Smith, W H Wilson Tang, Karine Clément, Stanley L Hazen, Fredrik Bäckhed
JACC. Heart failure - 2023 -
Psychosocial work conditions and prediabetes risks: a cross-sectional study in middle-aged men and
women.
Caroline Schmidt, Anders Gummesson, Fredrik Bäckhed, Göran Bergström, Mia Söderberg
Scientific reports - 2023 -
Cold Exposure and Oral Delivery of GLP-1R Agonists by an Engineered Probiotic Yeast Strain Have Antiobesity Effects in
Mice
Karl Alex Hedin, Hongbin Zhang, Vibeke Kruse, Vanessa Emily Rees, Fredrik Bäckhed, Thomas U. Greiner, Ruben Vazquez-Uribe, Morten Otto Alexander Sommer
ACS Synthetic Biology - 2023 -
Mediating role of atherogenic lipoproteins in the relationship between liver fat and coronary artery
calcification
Elias Björnson, Dimitrios Samaras, Martin Adiels, J. Kullberg, Fredrik Bäckhed, Göran Bergström, Anders Gummesson
Scientific Reports - 2023 -
Atlas of gut microbe-derived products from aromatic amino acids and risk of cardiovascular morbidity and
mortality
I. Nemet, X. M. S. Li, A. Haghikia, L. Li, J. Wilcox, K. A. Romano, J. A. Buffa, M. Witkowski, I. Demuth, M. Konig, E. Steinhagen-Thiessen, Fredrik Bäckhed, M. A. Fischbach, W. H. W. Tang, U. Landmesser, S. L. Hazen
European Heart Journal - 2023 -
Commensal bacteria weaken the intestinal barrier by suppressing epithelial neuropilin-1 and Hedgehog
signaling
G. Pontarollo, B. Kollar, A. Mann, M. P. Khuu, K. Kiouptsi, F. Bayer, I. Brandao, V. V. Zinina, J. Hahlbrock, F. Malinarich, M. Mimmler, S. Bhushan, F. Marini, W. Ruf, M. Belheouane, J. F. Baines, K. Endres, S. M. Reba, V. K. Raker, C. Deppermann, C. Welsch, M. Bosmann, N. Soshnikova, B. Chassaing, Mattias Bergentall, F. Sommer, Fredrik Bäckhed, C. Reinhardt
Nature Metabolism - 2023 -
Gut bacterial metabolism contributes to host global purine
homeostasis
K. Kasahara, R. L. Kerby, Q. J. Zhang, Meenakshi Pradhan, M. Mehrabian, A. J. Lusis, Göran Bergström, Fredrik Bäckhed, F. E. Rey
Cell Host & Microbe - 2023 -
Self-organized metabotyping of obese individuals identifies clusters responding differently to bariatric
surgery
D. Lappa, A. S. Meijnikman, Kimberly A. Krautkramer, Lisa M. Olsson, O. Aydin, A. S. Van Rijswijk, Y. I. Z. Acherman, M. L. De Brauw, Valentina Tremaroli, Louise Olofsson, Annika Lundqvist, S. A. Hjorth, B. Y. Ji, V. E. A. Gerdes, A. K. Groen, T. W. Schwartz, Max Nieuwdorp, Fredrik Bäckhed, J. Nielsen
Plos One - 2023 -
Pre-diabetes is associated with attenuation rather than volume of epicardial adipose tissue on computed
tomography
David Molnar, Elias Björnson, M. Larsson, Martin Adiels, Anders Gummesson, Fredrik Bäckhed, Ola Hjelmgren, Göran Bergström
Scientific Reports - 2023 -
Impairment of gut microbial biotin metabolism and host biotin status in severe obesity: effect of biotin and prebiotic supplementation on improved
metabolism
E. Belda, L. Voland, Valentina Tremaroli, G. Falony, S. Adriouch, K. E. Assmann, E. Prifiti, J. Aron-Wisnewsky, J. Debedat, T. Le Roy, T. Nielsen, C. Amouyal, S. Andre, F. Andreelli, M. Bluher, R. Chakaroun, J. Chilloux, L. P. Coelho, M. C. Dao, P. Das, S. Fellahi, S. Forslund, N. Galleron, T. H. Hansen, B. Holmes, B. Y. Ji, H. K. Pedersen, P. Le, E. Le Chatelier, C. Lewinter, Louise Mannerås Holm, F. Marquet, A. Myridakis, V. Pelloux, N. Pons, B. Quinquis, C. Rouault, H. Roume, J. E. Salem, N. Sokolovska, N. B. Sondertoft, S. Touch, S. Vieira-Silva, P. Galan, J. Holst, J. P. Gotze, L. Kober, H. Vestergaard, T. Hansen, S. Hercberg, J. M. Oppert, J. Nielsen, I. Letunic, M. E. Dumas, M. Stumvoll, O. B. Pedersen, P. Bork, S. D. Ehrlich, J. D. Zucker, Fredrik Bäckhed, J. Raes, K. Clement
Gut - 2022 -
A systems biology approach to study non-alcoholic fatty liver (NAFL) in women with
obesity
A. S. Meijnikman, D. Lappa, H. Herrema, O. Aydin, Kimberly A. Krautkramer, Valentina Tremaroli, Louise Olofsson, A. Lundqvist, S. Bruin, Y. Acherman, J. Verheij, S. Hjorth, V. E. A. Gerdes, T. W. Schwartz, A. K. Groen, Fredrik Bäckhed, J. Nielsen, M. Nieuwdorp
iScience - 2022 -
Type 2 diabetes is associated with increased circulating levels of 3-hydroxydecanoate activating GPR84 and neutrophil
migration
R. B. Mikkelsen, T. Arora, K. Trošt, O. Dmytriyeva, S. K. Jensen, A. S. Meijnikman, Louise Olofsson, D. Lappa, Ö Aydin, J. Nielsen, V. Gerdes, T. Moritz, A. van de Laar, M. de Brauw, M. Nieuwdorp, S. A. Hjorth, T. W. Schwartz, Fredrik Bäckhed
iScience - 2022 -
Dynamics of the normal gut microbiota: A longitudinal one-year population study in
Sweden
Lisa M. Olsson, F. Boulund, Staffan Nilsson, Muhammad Tanweer Khan, Anders Gummesson, L. Fagerberg, L. Engstrand, Rosie Perkins, M. Uhlén, Göran Bergström, Valentina Tremaroli, Fredrik Bäckhed
Cell Host and Microbe - 2022 -
Hyperinsulinemia Is Highly Associated With Markers of Hepatocytic Senescence in Two Independent
Cohorts
A. S. Meijnikman, C. C. van Olden, Ö Aydin, H. Herrema, D. Kaminska, D. Lappa, V. Männistö, Valentina Tremaroli, Louise Olofsson, M. de Brauw, A. van de Laar, J. Verheij, V. E. A. Gerdes, T. W. Schwartz, J. Nielsen, Fredrik Bäckhed, P. Pajukanta, J. Pihlajamäki, T. Tchkonia, J. L. Kirkland, F. Kuipers, M. Nieuwdorp, A. K. Groen
Diabetes - 2022 -
Adipose Tissue, Bile Acids, and Gut Microbiome Species Associated With Gallstones After Bariatric
Surgery
M. S. S. Guman, J. B. Hoozemans, S. Haal, P. A. de Jonge, Ö Aydin, D. Lappa, A. S. Meijnikman, F. Westerink, Y. Acherman, Fredrik Bäckhed, M. de Brauw, J. Nielsen, M. Nieuwdorp, A. K. Groen, V. E. A. Gerdes
Journal of lipid research - 2022 -
Microbiome-derived ethanol in nonalcoholic fatty liver
disease
A. S. Meijnikman, M. Davids, H. Herrema, O. Aydin, Valentina Tremaroli, M. Rios-Morales, H. Levels, S. Bruin, M. de Brauw, J. Verheij, M. Kemper, A. G. Holleboom, M. E. Tushuizen, T. W. Schwartz, J. Nielsen, D. Brandjes, E. Dirinck, J. Weyler, A. Verrijken, C. E. M. De Block, L. Vonghia, S. Francque, U. Beuers, V. E. A. Gerdes, Fredrik Bäckhed, A. K. Groen, M. Nieuwdorp
Nature Medicine - 2022 -
Gut microbial characteristics in poor appetite and undernutrition: a cohort of older adults and microbiota transfer in germ-free
mice
K. S. Fluitman, M. Davids, Louise Olofsson, M. Wijdeveld, Valentina Tremaroli, B. J. F. Keijser, M. Visser, Fredrik Bäckhed, M. Nieuwdorp, R. G. Ijzerman
Journal of Cachexia Sarcopenia and Muscle - 2022 -
The Metabolic Role and Therapeutic Potential of the
Microbiome
Louise Olofsson, Fredrik Bäckhed
Endocrine Reviews - 2022 -
Microbiome and metabolome features of the cardiometabolic disease
spectrum
S. Fromentin, S. K. Forslund, K. Chechi, J. Aron-Wisnewsky, R. Chakaroun, T. Nielsen, Valentina Tremaroli, B. Y. Ji, E. Prifti, A. Myridakis, J. Chilloux, P. Andrikopoulos, Y. Fan, M. T. Olanipekun, R. Alves, S. Adiouch, N. Bar, Y. Talmor-Barkan, E. Belda, Robert Caesar, L. P. Coelho, G. Falony, S. Fellahi, P. Galan, N. Galleron, G. Helft, L. Hoyles, R. Isnard, E. Le Chatelier, H. Julienne, Lisa M. Olsson, H. K. Pedersen, N. Pons, B. Quinquis, C. Rouault, H. Roume, J. E. Salem, T. S. B. Schmidt, S. Vieira-Silva, P. S. Li, M. Zimmermann-Kogadeeva, C. Lewinter, N. B. Sondertoft, T. H. Hansen, D. Gauguier, J. P. Gotze, L. Kober, R. Kornowski, H. Vestergaard, T. Hansen, J. D. Zucker, S. Hercberg, I. Letunic, Fredrik Bäckhed, J. M. Oppert, J. Nielsen, J. Raes, P. Bork, M. Stumvoll, E. Segal, K. Clement, M. E. Dumas, S. D. Ehrlich, O. Pedersen
Nature Medicine - 2022 -
Duodenal Anaerobutyricum soehngenii infusion stimulates GLP-1 production, ameliorates glycaemic control and beneficially shapes the duodenal transcriptome in metabolic syndrome subjects: a randomised double-blind placebo-controlled cross-over
study
A. Koopen, J. Witjes, K. Wortelboer, S. Majait, A. Prodan, E. Levin, H. Herrema, M. Winkelmeijer, S. Aalvink, Jjghm Bergman, S. Havik, B. Hartmann, H. Levels, Per-Olof Bergh, J. van Son, M. Balvers, D. M. Bastos, E. Stroes, A. K. Groen, Marcus Henricsson, E. M. Kemper, J. Holst, C. M. Strauch, S. L. Hazen, Fredrik Bäckhed, W. M. De Vos, M. Nieuwdorp, E. Rampanelli
Gut - 2022 -
Propionate attenuates atherosclerosis by immune-dependent regulation of intestinal cholesterol
metabolism
A. Haghikia, F. Zimmermann, P. Schumann, A. Jasina, J. Roessler, D. Schmidt, P. Heinze, J. Kaisler, V. Nageswaran, A. Aigner, U. Ceglarek, R. Cineus, A. N. Hegazy, E. P. C. van der Vorst, Y. Doring, C. M. Strauch, I. Nemet, Valentina Tremaroli, Chinmay Dwibedi, N. Krankel, D. M. Leistner, M. M. Heimesaat, S. Bereswill, G. Rauch, U. Seeland, O. Soehnlein, D. N. Muller, R. Gold, Fredrik Bäckhed, S. L. Hazen, A. Haghikia, U. Landmesser
European Heart Journal - 2022 -
Challenging the Hypothesis of de novo Biosynthesis of Bile Acids by Marine
Bacteria
F. G. Tueros, M. M. Hashim Ellabaan, Marcus Henricsson, R. Vazquez-Uribe, Fredrik Bäckhed, M. O. A. Sommer
Microbiology and Biotechnology Letters - 2022 -
The effects of laparoscopic Roux-en-Y gastric bypass and one-anastomosis gastric bypass on glycemic control and remission of type 2 diabetes mellitus: study protocol for a multi-center randomized controlled trial (the
DIABAR-trial)
A. van Rijswijk, N. van Olst, A. S. Meijnikman, Y. I. Z. Acherman, S. C. Bruin, A. W. van de Laar, C. C. van Olden, O. Aydin, H. Borger, U. H. W. Beuers, H. Herrema, J. Verheij, J. A. Apers, Fredrik Bäckhed, V. E. A. Gerdes, Max Nieuwdorp, L. M. de Brauw
Trials - 2022 -
Plasma Imidazole Propionate Is Positively Correlated with Blood Pressure in Overweight and Obese
Humans
J. van Son, M. J. Serlie, Marcus Ståhlman, Fredrik Bäckhed, M. Nieuwdorp, J. Aron-Wisnewsky
Nutrients - 2021 -
Gut microbial metabolites as multi-kingdom
intermediates
Kimberly A. Krautkramer, J. Fan, Fredrik Bäckhed
Nature Reviews Microbiology - 2021 -
Protein intake, metabolic status and the gut microbiota in different ethnicities: Results from two independent
cohorts
P. Bel Lassen, I. Attaye, S. Adriouch, M. Nicolaou, J. Aron-Wisnewsky, T. Nielsen, R. Chakaroun, E. Le Chatelier, S. Forslund, E. Belda, P. Bork, Fredrik Bäckhed, M. Stumvoll, O. Pedersen, H. Herrema, A. K. Groen, S. J. Pinto-Sietsma, A. H. Zwinderman, M. Nieuwdorp, K. Clement
Nutrients - 2021 -
A Continuous Battle for Host-Derived Glycans Between a Mucus Specialist and a Glycan Generalist in vitro and in
vivo
I. Kostopoulos, S. Aalvink, Petia Kovatcheva-Datchary, B. Nijsse, Fredrik Bäckhed, J. Knol, W. M. de Vos, C. Belzer
Frontiers in Microbiology - 2021 -
Combinatorial, additive and dose-dependent drug-microbiome
associations
S. K. Forslund, R. Chakaroun, M. Zimmermann-Kogadeeva, L. Marko, J. Aron-Wisnewsky, T. Nielsen, L. Moitinho-Silva, T. S. B. Schmidt, G. Falony, S. Vieira-Silva, S. Adriouch, R. J. Alves, K. Assmann, J. P. Bastard, T. Birkner, Robert Caesar, J. Chilloux, L. P. Coelho, L. Fezeu, N. Galleron, G. Helft, R. Isnard, B. Y. Ji, M. Kuhn, E. Le Chatelier, A. Myridakis, Lisa M. Olsson, N. Pons, E. Prifti, B. Quinquis, H. Roume, J. E. Salem, N. Sokolovska, Valentina Tremaroli, M. Valles-Colomer, C. Lewinter, N. B. Sondertoft, H. K. Pedersen, T. H. Hansen, J. P. Gotze, L. Kober, H. Vestergaard, T. Hansen, J. D. Zucker, S. Hercberg, J. M. Oppert, I. Letunic, J. Nielsen, Fredrik Bäckhed, S. D. Ehrlich, M. E. Dumas, J. Raes, O. Pedersen, K. Clement, M. Stumvoll, P. Bork
Nature - 2021 -
Microbial regulation of hexokinase 2 links mitochondrial metabolism and cell death in
colitis
F. Hinrichsen, J. Hamm, M. Westermann, L. Schroder, K. Shima, N. Mishra, A. Walker, N. Sommer, K. Klischies, D. Prasse, J. Zimmermann, S. Kaiser, D. Bordoni, A. Fazio, G. Marinos, G. Laue, S. Imm, Valentina Tremaroli, M. Basic, R. Hasler, R. A. Schmitz, S. Krautwald, A. Wolf, B. Stecher, P. Schmitt-Kopplin, C. Kaleta, J. Rupp, Fredrik Bäckhed, P. Rosenstiel, F. Sommer
Cell Metabolism - 2021 -
Anorexia and Fat Aversion Induced by Vertical Sleeve Gastrectomy Is Attenuated in Neurotensin Receptor 1-Deficient
Mice
C. Ratner, J. H. Shin, Chinmay Dwibedi, Valentina Tremaroli, A. Bjerregaard, B. Hartmann, Fredrik Bäckhed, G. Leinninger, R. J. Seeley, B. Holst
Endocrinology - 2021 -
Conversion of dietary inositol into propionate and acetate by commensal Anaerostipes associates with host
health
T. P. N. Bui, Louise Mannerås Holm, R. Puschmann, Hao Wu, A. D. Troise, B. Nijsse, S. Boeren, Fredrik Bäckhed, D. Fiedler, W. M. deVos
Nature Communications - 2021 -
Maternal cecal microbiota transfer rescues early-life antibiotic-induced enhancement of type 1 diabetes in
mice
X. S. Zhang, Y. S. Yin, J. C. Wang, T. Battaglia, Kimberly A. Krautkramer, W. V. Li, J. Li, M. Brown, M. F. Zhang, M. H. Badri, A. J. S. Armstrong, C. M. Strauch, Z. N. Wang, I. Nemet, N. Altomare, J. C. Devlin, L. C. He, J. T. Morton, J. A. Chalk, K. Needles, V. Liao, J. Mount, H. L. Li, K. V. Ruggles, R. A. Bonneau, M. G. Dominguez-Bello, Fredrik Bäckhed, S. L. Hazen, M. J. Blaser
Cell Host & Microbe - 2021 -
Microbial regulation of enteroendocrine
cells
T. Arora, A. M. Vanslette, S. A. Hjorth, Fredrik Bäckhed
Med - 2021 -
Short Article Hypothalamic bile acid-TGR5 signaling protects from
obesity
A. Castellanos-Jankiewicz, O. Guzman-Quevedo, V. S. Fenelon, P. Zizzari, C. Quarta, L. Bellocchio, A. Tailleux, J. Charton, D. Fernandois, Marcus Henricsson, C. Piveteau, V. Simon, C. Allard, S. Quemener, V. Guinot, N. Hennuyer, A. Perino, A. Duveau, M. Maitre, T. Leste-Lasserre, S. Clark, N. Dupuy, A. Cannich, D. Gonzales, B. Deprez, G. Mithieux, D. Dombrowicz, Fredrik Bäckhed, V. Prevot, G. Marsicano, B. Staels, K. Schoonjans, D. Cota
Cell Metabolism - 2021 -
Developmental trajectory of the healthy human gut microbiota during the first 5 years of
life
Josefine Roswall, Lisa M. Olsson, Petia Kovatcheva-Datchary, Staffan Nilsson, Valentina Tremaroli, Marie-Christine Simon, P. Kiilerich, Rozita Akrami, Manuela Krämer, M. Uhlen, Anders Gummesson, K. Kristiansen, Jovanna Dahlgren, Fredrik Bäckhed
Cell Host & Microbe - 2021 -
A systems biology approach to understand gut microbiota and host metabolism in morbid obesity: design of the BARIA Longitudinal Cohort
Study
C. C. Van Olden, A. W. Van de Laar, A. S. Meijnikman, O. Aydin, N. Van Olst, J. B. Hoozemans, L. M. De Brauw, S. C. Bruin, Y. I. Z. Acherman, J. Verheij, J. E. Pyykko, M. Hagedoorn, R. Sanderman, N. C. Bosma, Valentina Tremaroli, Annika Lundqvist, Louise Olofsson, H. Herrema, D. Lappa, S. Hjorth, J. Nielsen, T. Schwartz, A. K. Groen, M. Nieuwdorp, Fredrik Bäckhed, V. E. A. Gerdes
Journal of Internal Medicine - 2021 -
Longitudinal plasma protein profiling of newly diagnosed type 2
diabetes.
Anders Gummesson, Elias Björnson, Linn Fagerberg, Wen Zhong, Abdellah Tebani, Fredrik Edfors, Caroline Schmidt, Annika Lundqvist, Martin Adiels, Fredrik Bäckhed, Jochen M Schwenk, Per-Anders Jansson, Mathias Uhlén, Göran Bergström
EBioMedicine - 2021 -
Feeding diversified protein sources exacerbates hepatic insulin resistance via increased gut microbial branched-chain fatty acids and mTORC1 signaling in obese
mice
B. S. Y. Choi, N. Daniel, V. P. Houde, A. Ouellette, B. Marcotte, T. V. Varin, C. Vors, P. Feutry, O. Ilkayeva, Marcus Ståhlman, P. St-Pierre, Fredrik Bäckhed, A. Tremblay, P. J. White, A. Marette
Nature Communications - 2021 -
The gut microbiota regulates hypothalamic inflammation and leptin sensitivity in Western diet-fed mice via a GLP-1R-dependent
mechanism
Christina Heiss, Louise Mannerås Holm, Ying Shiuan Lee, Julia Serrano-Lobo, Anna Håkansson-Gladh, R. J. Seeley, D. J. Drucker, Fredrik Bäckhed, Louise Olofsson
Cell Reports - 2021 -
Structural characterization of the microbial enzyme urocanate reductase mediating imidazole propionate
production
R. Venskutonyte, Ara Koh, O. Stenstrom, Muhammad Tanweer Khan, Annika Lundqvist, M. Akke, Fredrik Bäckhed, K. Lindkvist-Petersson
Nature Communications - 2021 -
Associations between gutmicrobiota, faecal short-chain fatty acids, and blood pressure across ethnic groups: the HELIUS
study
B. J. H. Verhaar, D. Collard, A. Prodan, J. H. M. Levels, A. H. Zwinderman, Fredrik Bäckhed, L. Vogt, M. J. L. Peters, M. Muller, Max Nieuwdorp, B. J. H. van den Born
European Heart Journal - 2020 -
Effects of a Vegetarian Diet on Cardiometabolic Risk Factors, Gut Microbiota, and Plasma Metabolome in Subjects With Ischemic Heart Disease: A Randomized, Crossover
Study
D. Djekic, L. Shi, Harald Brolin, F. Carlsson, C. Sarnqvist, O. Savolainen, Y. Cao, Fredrik Bäckhed, Valentina Tremaroli, R. Landberg, O. Frobert
Journal of the American Heart Association - 2020 -
Gut microbiota of obese subjects with Prader-Willi syndrome is linked to metabolic
health
Lisa M. Olsson, C. Poitou, Valentina Tremaroli, M. Coupaye, J. Aron-Wisnewsky, Fredrik Bäckhed, K. Clément, Robert Caesar
Gut - 2020 -
Integration of molecular profiles in a longitudinal wellness profiling
cohort.
Abdellah Tebani, Anders Gummesson, Wen Zhong, Ina Schuppe Koistinen, Tadepally Lakshmikanth, Lisa M. Olsson, Fredrik Boulund, Maja Neiman, Hans Stenlund, Cecilia Hellström, Max J Karlsson, Muhammad Arif, Tea Dodig-Crnkovic, Adil Mardinoglu, Sunjae Lee, Cheng Zhang, Yang Chen, Axel Olin, Jaromir Mikes, Hanna Danielsson, Kalle von Feilitzen, Per-Anders Jansson, Oskar Angerås, Mikael Huss, Sanela Kjellqvist, Jacob Odeberg, Fredrik Edfors, Valentina Tremaroli, Björn Forsström, Jochen M Schwenk, Peter Nilsson, Thomas Moritz, Fredrik Bäckhed, Lars Engstrand, Petter Brodin, Göran Bergström, Mathias Uhlen, Linn Fagerberg
Nature communications - 2020 -
Imidazole propionate is increased in diabetes and associated with dietary patterns and altered microbial
ecology
Antonio Molinaro, Py Bel Lassen, Marcus Henricsson, Hao Wu, S. Adriouch, E. Belda, R. Chakaroun, T. Nielsen, Per-Olof Bergh, C. Rouault, S. Andre, F. Marquet, F. Andreelli, J. E. Salem, K. Assmann, J. P. Bastard, S. Forslund, E. Le Chatelier, G. Falony, N. Pons, E. Prifti, B. Quinquis, H. Roume, S. Vieira-Silva, T. H. Hansen, H. K. Pedersen, C. Lewinter, N. B. Sonderskov, L. Kober, H. Vestergaard, T. Hansen, J. D. Zucker, P. Galan, M. E. Dumas, J. Raes, J. M. Oppert, I. Letunic, J. Nielsen, P. Bork, S. D. Ehrlich, M. Stumvoll, O. Pedersen, J. Aron-Wisneswky, K. Clement, Fredrik Bäckhed
Nature Communications - 2020 -
Microbial Imidazole Propionate Affects Responses to Metformin through p38 gamma-Dependent Inhibitory AMPK
Phosphorylation
Ara Koh, Louise Mannerås Holm, N. O. Yunn, P. M. Nilsson, S. H. Ryu, Antonio Molinaro, Rosie Perkins, J. Gustav Smith, Fredrik Bäckhed
Cell Metabolism - 2020 -
The Gut Microbiota in Prediabetes and Diabetes: A Population-Based Cross-Sectional
Study
Hao Wu, Valentina Tremaroli, Caroline Schmidt, Annika Lundqvist, Lisa M. Olsson, Manuela Krämer, Anders Gummesson, Rosie Perkins, Göran Bergström, Fredrik Bäckhed
Cell Metabolism - 2020 -
Distinct differences in gut microbial composition and functional potential from lean to morbidly obese
subjects.
A. S. Meijnikman, O. Aydin, A. Prodan, Valentina Tremaroli, H. Herrema, E. Levin, Y. Acherman, S. Bruin, V. E. Gerdes, Fredrik Bäckhed, A. K. Groen, M. Nieuwdorp
Journal of Internal Medicine - 2020 -
Hepatic expression of lipopolysaccharide- binding protein ( Lbp ) is induced by the gut microbiota through Myd88 and impairs glucose tolerance in mice independent of
obesity
Antonio Molinaro, Ara Koh, Hao Wu, Marc Schöler, Maria Ilaria Faggi, Alba Carreras, Anna Hallén, Fredrik Bäckhed, Robert Caesar
Molecular Metabolism - 2020 -
L-Cell Differentiation Is Induced by Bile Acids Through GPBAR1 and Paracrine GLP-1 and Serotonin
Signaling
M. L. Lund, G. Sorrentino, K. L. Egerod, C. Kroone, B. Mortensen, F. K. Knop, F. Reimann, F. M. Gribble, D. J. Drucker, E. J. P. de Koning, K. Schoonjans, Fredrik Bäckhed, T. W. Schwartz, N. Petersen
Diabetes - 2020 -
Donor metabolic characteristics drive effects of faecal microbiota transplantation on recipient insulin sensitivity, energy expenditure and intestinal transit
time
P. De Groot, T. Scheithauer, G. J. Bakker, A. Prodan, E. Levin, Muhammad Tanweer Khan, H. Herrema, M. Ackermans, M. J. M. Serlie, M. De Brauw, J. H. M. Levels, A. Sales, Marcus Ståhlman, A. W. M. Schimmel, G. Dallinga-Thie, J. J. Bergman, F. Holleman, J. B. L. Hoekstra, A. Groen, Fredrik Bäckhed, M. Nieuwdorp
Gut - 2020 -
Protein Turnover in Epithelial Cells and Mucus along the Gastrointestinal Tract Is Coordinated by the Spatial Location and
Microbiota
Liisa Arike, A. Seiman, Sjoerd van der Post, Ana María Rodríguez-Piñeiro, Anna Ermund, André Schütte, Fredrik Bäckhed, Malin E V Johansson, Gunnar C. Hansson
Cell Reports - 2020 -
Obesity-associated microbiota contributes to mucus layer defects in genetically obese
mice
Björn O. Schröder, George M. H. Birchenough, Meenakshi Pradhan, Elisabeth E. L. Nyström, Marcus Henricsson, Gunnar C. Hansson, Fredrik Bäckhed
Journal of Biological Chemistry - 2020 -
Statin therapy is associated with lower prevalence of gut microbiota
dysbiosis
S. Vieira-Silva, G. Falony, E. Belda, T. Nielsen, J. Aron-Wisnewsky, R. Chakaroun, S. K. Forslund, K. Assmann, M. Valles-Colomer, T. T. D. Nguyen, S. Proost, E. Prifti, Valentina Tremaroli, N. Pons, E. Le Chatelier, F. Andreelli, J. P. Bastard, L. P. Coelho, N. Galleron, T. H. Hansen, J. S. Hulot, C. Lewinter, H. K. Pedersen, B. Quinquis, C. Rouault, H. Roume, J. E. Salem, N. B. Søndertoft, S. Touch, R. Alves, C. Amouyal, E. A. A. Galijatovic, O. Barthelemy, J. P. Batisse, M. Berland, R. Bittar, H. Blottière, F. Bosquet, R. Boubrit, O. Bourron, M. Camus, D. Cassuto, C. Ciangura, J. P. Collet, M. C. Dao, J. Debedat, M. Djebbar, A. Doré, L. Engelbrechtsen, S. Fellahi, S. Fromentin, P. Giral, M. Graine, A. Hartemann, B. Hartmann, G. Helft, S. Hercberg, M. Hornbak, R. Isnard, S. Jaqueminet, N. R. Jørgensen, H. Julienne, J. Justesen, J. Kammer, M. Kerneis, J. Khemis, N. Krarup, M. Kuhn, A. Lampuré, V. Lejard, F. Levenez, L. Lucas-Martini, R. Massey, N. Maziers, J. Medina-Stamminger, L. Moitinho-Silva, G. Montalescot, S. Moutel, L. P. Le Pavin, C. Poitou-Bernert, F. Pousset, L. Pouzoulet, S. Schmidt, J. Silvain, M. Svendstrup, T. Swartz, T. Vanduyvenboden, C. Vatier, E. Verger, S. Walther, M. E. Dumas, S. D. Ehrlich, P. Galan, J. P. Gøtze, T. Hansen, J. J. Holst, L. Køber, I. Letunic, J. Nielsen, J. M. Oppert, M. Stumvoll, H. Vestergaard, J. D. Zucker, P. Bork, O. Pedersen, Fredrik Bäckhed, K. Clément, J. Raes
Nature - 2020 -
From Association to Causality: the Role of the Gut Microbiota and Its Functional Products on Host
Metabolism
Ara Koh, Fredrik Bäckhed
Molecular Cell - 2020 -
Distinct alterations of gut morphology and microbiota characterize accelerated diabetes onset in nonobese diabetic
mice
Marie-Christine Simon, A. L. Reinbeck, C. Wessel, J. Heindirk, T. Jelenik, K. Kaul, J. Arreguin-Cano, A. Strom, M. Blaut, Fredrik Bäckhed, V. Burkart, M. Roden
Journal of Biological Chemistry - 2020 -
Obeticholic acid may increase the risk of gallstone formation in susceptible
patients.
Samer Al-Dury, Annika Wahlström, Katrin Panzitt, Anders Thorell, Marcus Ståhlman, Michael Trauner, Peter Fickert, Fredrik Bäckhed, Lars Fändriks, Martin Wagner, Hanns-Ulrich Marschall
Journal of hepatology - 2019 -
Liver-specific RORα deletion does not affect the metabolic susceptibility to western style diet
feeding.
Antonio Molinaro, Robert Caesar, Laurent L'homme, Ara Koh, Marcus Ståhlman, Bart Staels, Fredrik Bäckhed
Molecular metabolism - 2019 -
Shining light on microbial signaling to distant
organs
Fredrik Bäckhed
Proceedings of the National Academy of Sciences of the United States of America - 2019 -
Insulin-Driven PI3K-AKT Signaling in the Hepatocyte Is Mediated by Redundant PI3Kα and PI3Kβ Activities and Is Promoted by
RAS.
Angela Molinaro, Barbara Becattini, Arianna Mazzoli, Augusto Bleve, Lucia Radici, Ingela Maxvall, Victoria Rotter Sopasakis, Antonio Molinaro, Fredrik Bäckhed, Giovanni Solinas
Cell Metabolism - 2019 -
Abundance of gut Prevotella at baseline and metabolic response to barley
prebiotics
J. Sandberg, Petia Kovatcheva-Datchary, I. Bjorck, Fredrik Bäckhed, A. Nilsson
European Journal of Nutrition - 2019 -
Genes controlling the activation of natural killer lymphocytes are epigenetically remodeled in intestinal cells from germ-free
mice
A. Poupeau, C. Garde, K. Sulek, K. Citirikkaya, J. T. Treebak, M. Arumugam, D. Simar, Louise Olofsson, Fredrik Bäckhed, R. Barres
Faseb Journal - 2019 -
Microbial fermentation of flaxseed fibers modulates the transcriptome of GPR41-expressing enteroendocrine cells and protects mice against diet-induced
obesity
Tulika Arora, O. Rudenko, K. L. Egerod, A. S. Husted, Petia Kovatcheva-Datchary, Rozita Akrami, M. Kristensen, T. W. Schwartz, Fredrik Bäckhed
American Journal of Physiology - Endocrinology and Metabolism - 2019 -
Dietary destabilisation of the balance between the microbiota and the colonic mucus
barrier
George M. H. Birchenough, Björn O. Schröder, Fredrik Bäckhed, Gunnar C. Hansson
Gut microbes - 2019 -
Intestinal Microbiota in Cardiovascular Health and
Disease
W. H. W. Tang, Fredrik Bäckhed, U. Landmesser, S. L. Hazen
Journal of the American College of Cardiology - 2019 -
Simplified Intestinal Microbiota to Study Microbe-Diet-Host Interactions in a Mouse
Model
Petia Kovatcheva-Datchary, S. Shoaie, S. Lee, Annika Wahlström, I. Nookaew, Anna Hallén, Rosie Perkins, J. Nielsen, Fredrik Bäckhed
Cell Reports - 2019 -
Microbially Produced Imidazole Propionate Impairs Insulin Signaling through
mTORC1
Ara Koh, Antonio Molinaro, Marcus Ståhlman, Muhammad Tanweer Khan, Caroline Schmidt, Louise Mannerås Holm, Hao Wu, Alba Carreras, Louise Olofsson, Per-Olof Bergh, V. Gerdes, A. Hartstra, M. de Brauw, Rosie Perkins, Max Nieuwdorp, Göran Bergström, Fredrik Bäckhed
Cell - 2018 -
Lactobacillus reuteri reduces bone loss in older women with low bone mineral density: a randomized, placebo-controlled, double-blind, clinical
trial
Anna G Nilsson, Daniel Sundh, Fredrik Bäckhed, Mattias Lorentzon
Journal of Internal Medicine - 2018 -
Impact of Gut Microbiota and Diet on the Development of Atherosclerosis in Apoe(-/-)
Mice
Annika Lindskog Jonsson, Robert Caesar, Rozita Akrami, Christopher Reinhardt, Frida Fåk, Jan Borén, Fredrik Bäckhed
Arteriosclerosis Thrombosis and Vascular Biology - 2018 -
Glucose-lowering effects and mechanisms of the bile acid-sequestering resin
sevelamer
A. Bronden, K. Mikkelsen, D. P. Sonne, M. Hansen, C. Vaben, M. N. Gabe, M. Rosenkilde, Valentina Tremaroli, Hao Wu, Fredrik Bäckhed, J. F. Rehfeld, J. J. Holst, T. Vilsboll, F. K. Knop
Diabetes Obesity & Metabolism - 2018 -
Depicting the composition of gut microbiota in a population with varied ethnic origins but shared
geography
M. Deschasaux, K. E. Bouter, A. Prodan, E. Levin, A. K. Groen, H. Herrema, Valentina Tremaroli, G. J. Bakker, I. Attaye, S. J. Pinto-Sietsma, D. H. van Raalte, M. B. Snijder, M. Nicolaou, R. Peters, A. H. Zwinderman, Fredrik Bäckhed, Max Nieuwdorp
Nature Medicine - 2018 -
Gut microbiota dysbiosis is associated with malnutrition and reduced plasma amino acid levels: Lessons from genome-scale metabolic
modeling
M. Kumar, B. Y. Ji, P. Babaei, P. Das, D. Lappa, G. Ramakrishnan, T. E. Fox, R. Haque, W. A. Petri, Fredrik Bäckhed, J. Nielsen
Metabolic Engineering - 2018 -
The Impact of Dietary Fiber on Gut Microbiota in Host Health and
Disease
Kassem Makki, E. C. Deehan, J. Walter, Fredrik Bäckhed
Cell Host & Microbe - 2018 -
Exposure to the gut microbiota drives distinct methylome and transcriptome changes in intestinal epithelial cells during postnatal
development
W. H. Pan, Felix Sommer, M. Falk-Paulsen, T. Ulas, P. Best, A. Fazio, P. Kachroo, A. Luzius, M. Jentzsch, A. Rehman, F. Muller, T. Lengauer, J. Walter, S. Kunzel, J. F. Baines, S. Schreiber, A. Franke, J. L. Schultze, Fredrik Bäckhed, P. Rosenstiel
Genome Medicine - 2018 -
In vitro co-cultures of human gut bacterial species as predicted from co-occurrence network
analysis
P. Das, B. Y. Ji, Petia Kovatcheva-Datchary, Fredrik Bäckhed, J. Nielsen
Plos One - 2018 -
Reduced obesity, diabetes, and steatosis upon cinnamon and grape pomace are associated with changes in gut microbiota and markers of gut
barrier
M. Van Hul, L. Geurts, H. Plovier, C. Druart, A. Everard, Marcus Ståhlman, M. Rhimi, K. Chira, P. L. Teissedre, N. M. Delzenne, E. Maguin, A. Guilbot, A. Brochot, P. Gerard, Fredrik Bäckhed, P. D. Cani
American Journal of Physiology-Endocrinology and Metabolism - 2018 -
Specific synbiotics in early life protect against diet-induced obesity in adult
mice
M. Mischke, Tulika Arora, S. Tims, E. Engels, Nina Sommer, K. van Limpt, A. Baars, R. Oozeer, A. Oosting, Fredrik Bäckhed, J. Knol
Diabetes Obesity & Metabolism - 2018 -
An Integrated Understanding of the Rapid Metabolic Benefits of a Carbohydrate-Restricted Diet on Hepatic Steatosis in
Humans
A. Mardinoglu, Hao Wu, Elias Björnson, C. Zhang, A. Hakkarainen, S. M. Rasanen, S. Lee, Rosellina Margherita Mancina, Mattias Bergentall, K. H. Pietilainen, S. Soderlund, N. Matikainen, Marcus Ståhlman, Per-Olof Bergh, Martin Adiels, B. D. Piening, M. Graner, N. Lundbom, Kevin Jon Williams, Stefano Romeo, J. Nielsen, M. Snyder, M. Uhlen, Göran Bergström, Rosie Perkins, Hanns-Ulrich Marschall, Fredrik Bäckhed, M. R. Taskinen, Jan Borén
Cell Metabolism - 2018 -
Aberrant intestinal microbiota in individuals with
prediabetes
K. H. Allin, V. Tremaroli, Robert Caesar, B. A. H. Jensen, M. T. F. Damgaard, M. I. Bahl, T. R. Licht, T. H. Hansen, T. Nielsen, T. M. Dantoft, A. Linneberg, T. Jorgensen, H. Vestergaard, K. Kristiansen, P. W. Franks, T. Hansen, Fredrik Bäckhed, O. Pedersen
Diabetologia - 2018 -
Enterotypes in the landscape of gut microbial community
composition
P. I. Costea, F. Hildebrand, A. Manimozhiyan, Fredrik Bäckhed, M. J. Blaser, F. D. Bushman, W. M. de Vos, S. D. Ehrlich, C. M. Fraser, M. Hattori, C. Huttenhower, I. B. Jeffery, D. Knights, J. D. Lewis, R. E. Ley, H. Ochman, P. W. O'Toole, C. Quince, D. A. Relman, F. Shanahan, S. Sunagawa, Jun Wang, G. M. Weinstock, G. D. Wu, G. Zeller, L. P. Zhao, J. Raes, R. Knight, P. Bork
Nature Microbiology - 2018 -
Interactions between Roseburia intestinalis and diet modulate atherogenesis in a murine
model
K. Kasahara, K. A. Krautkramer, E. Org, K. A. Romano, R. L. Kerby, E. I. Vivas, M. Mehrabian, J. M. Denu, Fredrik Bäckhed, A. J. Lusis, F. E. Rey
Nature Microbiology - 2018 -
Bifidobacteria or Fiber Protects against Diet-Induced Microbiota-Mediated Colonic Mucus
Deterioration
Björn O. Schröder, George M. H. Birchenough, Marcus Ståhlman, Liisa Arike, Malin E V Johansson, Gunnar C. Hansson, Fredrik Bäckhed
Cell Host & Microbe - 2018 -
Neonatal selection by Toll-like receptor 5 influences long-term gut microbiota
composition
M. Fulde, Felix Sommer, B. Chassaing, K. van Vorst, A. Dupont, M. Hensel, M. Basic, R. Klopfleisch, P. Rosenstiel, A. Bleich, Fredrik Bäckhed, A. T. Gewirtz, M. W. Hornef
Nature - 2018 -
Gut microbiota regulates maturation of the adult enteric nervous system via enteric serotonin
networks
Filipe De Vadder, Estelle Grasset, Louise Mannerås Holm, G. Karsenty, A. J. Macpherson, Louise Olofsson, Fredrik Bäckhed
Proceedings of the National Academy of Sciences of the United States of America - 2018 -
Microbial regulation of the L cell
transcriptome
Tulika Arora, Rozita Akrami, R. Pais, Linda Bergqvist, Bengt R Johansson, T. W. Schwartz, F. Reimann, F. M. Gribble, Fredrik Bäckhed
Scientific Reports - 2018 -
Bacterial profile in human atherosclerotic
plaques
Annika Lindskog Jonsson, Frida Fåk, Rozita Akrami, E. Johansson, P. Wester, C. Arnerlöv, Fredrik Bäckhed, Göran Bergström
Atherosclerosis - 2017 -
Crosstalk between Bile Acids and Gut Microbiota and Its Impact on Farnesoid X Receptor
Signalling
Annika Wahlström, Petia Kovatcheva-Datchary, Marcus Ståhlman, Fredrik Bäckhed, Hanns-Ulrich Marschall
Digestive Diseases - 2017 -
Intestinal Ralstonia pickettii augments glucose intolerance in
obesity
S. D. Udayappan, Petia Kovatcheva-Datchary, G. J. Bakker, S. R. Havik, H. Herrema, P. D. Cani, K. E. Bouter, C. Belzer, J. J. Witjes, A. Vrieze, N. de Sonnaville, A. Chaplin, D. H. van Raalte, S. Aalvink, G. M. Dallinga-Thie, Hghj Heilig, Göran Bergström, S. van der Meij, B. A. van Wagensveld, J. B. L. Hoekstra, F. Holleman, E. S. G. Stroes, A. K. Groen, Fredrik Bäckhed, W. M. de Vos, Max Nieuwdorp
Plos One - 2017 -
Evolution, human-microbe interactions, and life history
plasticity
G. Rook, Fredrik Bäckhed, B. R. Levin, M. J. McFall-Ngai, A. R. McLean
Lancet - 2017 -
Network analyses identify liver-specific targets for treating liver
diseases.
Sunjae Lee, Cheng Zhang, Zhengtao Liu, Martina Klevstig, Bani Mukhopadhyay, Mattias Bergentall, Resat Cinar, Marcus Ståhlman, Natasha Sikanic, Joshua K Park, Sumit Deshmukh, Azadeh M Harzandi, Tim Kuijpers, Morten Grøtli, Simon J Elsässer, Brian D Piening, Michael Snyder, Ulf Smith, Jens Nielsen, Fredrik Bäckhed, George Kunos, Mathias Uhlen, Jan Borén, Adil Mardinoglu
Molecular systems biology - 2017 -
Diabetes-associated microbiota in fa/fa rats is modified by Roux-en-Y gastric
bypass
Tulika Arora, F. Seyfried, Neil G. Docherty, Valentina Tremaroli, Carel W le Roux, Rosie Perkins, Fredrik Bäckhed
Isme Journal - 2017 -
Metformin alters the gut microbiome of individuals with treatment-naive type 2 diabetes, contributing to the therapeutic effects of the
drug
Hao Wu, E. Esteve, Valentina Tremaroli, Muhammad Tanweer Khan, Robert Caesar, Louise Mannerås Holm, Marcus Ståhlman, Lisa M. Olsson, M. Serino, M. Planas-Felix, G. Xifra, J. M. Mercader, D. Torrents, R. Burcelin, W. Ricart, Rosie Perkins, J. M. Fernandez-Real, Fredrik Bäckhed
Nature Medicine - 2017 -
Regulation of bone mass by the gut microbiota is dependent on NOD1 and NOD2
signaling
Claes Ohlsson, G. Nigro, I. G. Boneca, Fredrik Bäckhed, P. Sansonetti, Klara Sjögren
Cellular Immunology - 2017 -
Overexpressing the novel autocrine/endocrine adipokine WISP2 induces hyperplasia of the heart, white and brown adipose tissues and prevents insulin
resistance.
John Grünberg, Jenny M Hoffmann, Shahram Hedjazifar, Annika Nerstedt, Lachmi E Jenndahl, Johannes Elvin, John Castellot, Lan Wei, Sofia Movérare-Skrtic, Claes Ohlsson, Louise Mannerås Holm, Fredrik Bäckhed, Ismail Syed, Fatima Bosch, Alan Saghatelian, Barbara B Kahn, Ann Hammarstedt, Ulf Smith
Scientific reports - 2017 -
Metabolic effects of Lactobacillus reuteri DSM 17938 in people with type 2 diabetes: A randomized controlled
trial
Reza Mobini, Valentina Tremaroli, Marcus Ståhlman, F. Karlsson, Max Levin, Maria Ljungberg, Maja Sohlin, Helene Berteus Forslund, Rosie Perkins, Fredrik Bäckhed, Per-Anders Jansson
Diabetes Obesity & Metabolism - 2017 -
Induction of FXR signaling in germ-free mice colonized with a human
microbiota.
Annika Wahlström, Petia Kovatcheva-Datchary, Marcus Ståhlman, Muhammad Tanweer Khan, Fredrik Bäckhed, Hanns-Ulrich Marschall
Journal of lipid research - 2017 -
The gut microbiota contributes to a mouse model of spontaneous bile duct
inflammation
E. Schrumpf, M. Kummen, L. Valestrand, Thomas U. Greiner, K. Holm, V. Arulampalam, H. M. Reims, J. Baines, Fredrik Bäckhed, T. H. Karlsen, R. S. Blumberg, J. R. Hov, E. Melum
Journal of Hepatology - 2017 -
Hepatocyte MyD88 affects bile acids, gut microbiota and metabolome contributing to regulate glucose and lipid
metabolism
T. Duparc, H. Plovier, V. G. Marrachelli, M. Van Hul, A. Essaghir, Marcus Ståhlman, S. Matamoros, L. Geurts, M. M. Pardo-Tendero, C. Druart, N. M. Delzenne, J. B. Demoulin, S. W. van der Merwe, J. van Pelt, Fredrik Bäckhed, D. Monleon, A. Everard, P. D. Cani
Gut - 2017 -
Cyp3a11 is not essential for the formation of murine bile
acids
Annika Wahlström, Samer Al-Dury, Marcus Ståhlman, Fredrik Bäckhed, Hanns-Ulrich Marschall
Biochemistry and Biophysics Reports - 2017 -
Microbiota-induced obesity requires farnesoid X
receptor
Ava Parseus, Nina Sommer, Felix Sommer, Robert Caesar, Antonio Molinaro, Marcus Ståhlman, Thomas U. Greiner, Rosie Perkins, Fredrik Bäckhed
Gut - 2017 -
Overexpression of protein kinase STK25 in mice exacerbates ectopic lipid accumulation, mitochondrial dysfunction and insulin resistance in skeletal
muscle.
Urszula Chursa, Esther Nuñez Durán, Emmelie Cansby, Manoj Amrutkar, Silva Sütt, Marcus Ståhlman, Britt-Marie Olsson, Jan Borén, Maria Johansson, Fredrik Bäckhed, Bengt R Johansson, Carina Sihlbom, Margit Mahlapuu
Diabetologia - 2017 -
Host–microbiota interaction induces bi-phasic inflammation and glucose intolerance in
mice
Antonio Molinaro, Robert Caesar, Louise Mannerås Holm, Valentina Tremaroli, P. D. Cani, Fredrik Bäckhed
Molecular Metabolism - 2017 -
Role of gut microbiota in
atherosclerosis
Annika Lindskog, Fredrik Bäckhed
Nature Reviews Cardiology - 2017 -
Intestinal Crosstalk between Bile Acids and Microbiota and Its Impact on Host
Metabolism.
Annika Wahlström, Sama I. Sayin, Hanns-Ulrich Marschall, Fredrik Bäckhed
Cell metabolism - 2016 -
The gut microbiota and metabolic disease: current understanding and future
perspectives
Tulika Arora, Fredrik Bäckhed
Journal of Internal Medicine - 2016 -
Altered Microbiota Contributes to Reduced Diet-Induced Obesity upon Cold
Exposure
M. Zietak, Petia Kovatcheva-Datchary, L. H. Markiewicz, Marcus Ståhlman, L. P. Kozak, Fredrik Bäckhed
Cell Metabolism - 2016 -
Microbial regulation of GLP-1 and L-cell
biology
Thomas U. Greiner, Fredrik Bäckhed
Molecular Metabolism - 2016 -
From Dietary Fiber to Host Physiology: Short-Chain Fatty Acids as Key Bacterial
Metabolites
Ara Koh, Filipe De Vadder, Petia Kovatcheva-Datchary, Fredrik Bäckhed
Cell - 2016 -
Regulation of body fat mass by the gut microbiota: Possible mediation by the
brain.
Erik Schéle, Louise Grahnemo, Fredrik Anesten, Anna Hallén, Fredrik Bäckhed, John-Olov Jansson
Peptides - 2016 -
Insulin-like peptide 5 is a microbially regulated peptide that promotes hepatic glucose
production
Ying Shiuan Lee, Filipe De Vadder, Valentina Tremaroli, Anita Wichmann, G. Mithieux, Fredrik Bäckhed
Molecular Metabolism - 2016 -
Neurotensin Is Coexpressed, Coreleased, and Acts Together With GLP-1 and PYY in Enteroendocrine Control of
Metabolism
K. V. Grunddal, C. F. Ratner, B. Svendsen, Felix Sommer, M. S. Engelstoft, A. N. Madsen, J. Pedersen, M. K. Nohr, K. L. Egerod, A. R. Nawrocki, T. Kowalski, A. D. Howard, S. S. Poulsen, S. Offermanns, Fredrik Bäckhed, J. J. Holst, B. Holst, T. W. Schwartz
Endocrinology - 2016 -
Could gut microbiota protect against sclerosing
cholangitis?
Hanns-Ulrich Marschall, Fredrik Bäckhed
Hepatology (Baltimore, Md.) - 2016 -
Oral treatment with Eubacterium hallii improves insulin sensitivity in db/db
mice
Shanthadevi Udayappan, Louise Mannerås Holm, Alice Chaplin-Scott, Clara Belzer, Hilde Herrema, Geesje M. Dallinga-Thie, Silvia H. Duncan, Erik S.G. Stroes, Albert K. Groen, Harry J. Flint, Fredrik Bäckhed, Willem M. De Vos, Max Nieuwdorp
npj Biofilms and Microbiomes - 2016 -
Antibiotic-mediated gut microbiome perturbation accelerates development of type 1 diabetes in
mice
A. E. Livanos, Thomas U. Greiner, P. Vangay, W. Pathmasiri, D. Stewart, S. McRitchie, H. Li, J. Chung, J. Sohn, S. Kim, Z. Gao, C. Barber, J. Kim, S. Ng, A. B. Rogers, S. Sumner, X. S. Zhang, K. Cadwell, D. Knights, A. Alekseyenko, Fredrik Bäckhed, M. J. Blaser
Nature Microbiology - 2016 -
Microbially produced glucagon-like peptide 1 improves glucose tolerance in
mice
Tulika Arora, U. Wegmann, A. Bobhate, Ying Shiuan Lee, Thomas U. Greiner, D. J. Drucker, A. Narbad, Fredrik Bäckhed
Molecular Metabolism - 2016 -
Signals from the gut microbiota to distant organs in physiology and
disease.
Björn O. Schröder, Fredrik Bäckhed
Nature medicine - 2016 -
Microbiota-Produced Succinate Improves Glucose Homeostasis via Intestinal
Gluconeogenesis
Filipe De Vadder, Petia Kovatcheva-Datchary, C. Zitoun, A. Duchampt, Fredrik Bäckhed, G. Mithieux
Cell Metabolism - 2016 -
Diet-microbiota interactions as moderators of human
metabolism
J. L. Sonnenburg, Fredrik Bäckhed
Nature - 2016 -
Age-Dependent Susceptibility to Enteropathogenic Escherichia coli (EPEC) Infection in
Mice
A. Dupont, Felix Sommer, K. Zhang, U. Repnik, M. Basic, A. Bleich, M. Kuehnel, Fredrik Bäckhed, Y. Litvak, M. Fulde, I. Rosenshine, M. W. Hornef
Plos Pathogens - 2016 -
Interaction between dietary lipids and gut microbiota regulates hepatic cholesterol
metabolism
Robert Caesar, H. Nygren, M. Oresic, Fredrik Bäckhed
Journal of Lipid Research - 2016 -
Know your neighbor: Microbiota and host epithelial cells interact locally to control intestinal function and
physiology
Felix Sommer, Fredrik Bäckhed
Bioessays - 2016 -
The Gut Microbiota Modulates Energy Metabolism in the Hibernating Brown Bear Ursus
arctos
Felix Sommer, Marcus Ståhlman, O. Ilkayeva, J. M. Arnemo, J. Kindberg, J. Josefsson, C. B. Newgard, O. Frobert, Fredrik Bäckhed
Cell Reports - 2016 -
Dynamics and Stabilization of the Human Gut Microbiome during the First Year of
Life
Fredrik Bäckhed, Josefine Roswall, Y. Q. Peng, Qing-Ping Feng, H. J. Jia, Petia Kovatcheva-Datchary, Y Liu, Y. Xia, H. L. Xie, H. Z. Zhong, Muhammad Tanweer Khan, J. F. Zhang, J. H. Li, L. Xiao, J. Al-Aama, D. Y. Zhang, Ying Shiuan Lee, D. Kotowska, C. Colding, Valentina Tremaroli, Y. Yin, Stefan Bergman, X. Xu, L. Madsen, K. Kristiansen, Jovanna Dahlgren, W. Jun
Cell Host & Microbe - 2015 -
Quantifying Diet-Induced Metabolic Changes of the Human Gut
Microbiome
Saeed Shoaie, Pouyan Ghaffari Nouran, Petia Kovatcheva-Datchary, Adil Mardinoglu, Partho Sarathi Sen, E. Pujos-Guillot, T. de Wouters, C. Juste, S. Rizkalla, J. Chilloux, L. Hoyles, J. K. Nicholson, J. Dore, M. E. Dumas, K. Clement, Fredrik Bäckhed, Jens B. Nielsen
Cell Metabolism - 2015 -
The composition of the gut microbiota shapes the colon mucus
barrier.
Hedvig E Jakobsson, Ana María Rodríguez-Piñeiro, André Schütte, Anna Ermund, Preben Boysen, Mats Bemark, Felix Sommer, Fredrik Bäckhed, Gunnar C. Hansson, Malin E V Johansson
EMBO reports - 2015 -
Normalization of Host Intestinal Mucus Layers Requires Long-Term Microbial
Colonization
Malin E V Johansson, Hedvig E Jakobsson, Jessica Holmén Larsson, André Schütte, Anna Ermund, Ana María Rodríguez-Piñeiro, Liisa Arike, Catharina Wising, Frida Svensson, Fredrik Bäckhed, Gunnar C. Hansson
Cell Host & Microbe - 2015 -
Drug the
Bug!
Annika Lindskog Jonsson, Fredrik Bäckhed
Cell - 2015 -
Roux-en-Y Gastric Bypass and Vertical Banded Gastroplasty Induce Long-Term Changes on the Human Gut Microbiome Contributing to Fat Mass
Regulation
Valentina Tremaroli, Fredrik H. Karlsson, Malin Werling, Marcus Ståhlman, Petia Kovatcheva-Datchary, Torsten Olbers, Lars Fändriks, Carel W le Roux, Jens B. Nielsen, Fredrik Bäckhed
Cell Metabolism - 2015 -
The gut microbiota modulates host amino acid and glutathione metabolism in
mice
Adil Mardinoglu, Saeed Shoaie, Mattias Bergentall, Pouyan Ghaffari Nouran, C. Zhang, Erik Larsson, Fredrik Bäckhed, Jens B. Nielsen
Molecular Systems Biology - 2015 -
Linking Microbiota to Human Diseases: A Systems Biology
Perspective
Hao Wu, Valentina Tremaroli, Fredrik Bäckhed
Trends in Endocrinology and Metabolism - 2015 -
The Gut Microbiota Reduces Colonization of the Mesenteric Lymph Nodes and IL-12-Independent IFN-gamma Production During Salmonella
Infection
Maria Fernández-Santoscoy, Ulf Alexander Wenzel, Ulf Yrlid, Susanna Cardell, Fredrik Bäckhed, Mary Jo Wick
Frontiers in Cellular and Infection Microbiology - 2015 -
The short-chain fatty acid receptor, FFA2, contributes to gestational glucose
homeostasis
M. Fuller, M. Priyadarshini, S. M. Gibbons, A. R. Angueira, M. Brodsky, M. Geoffrey Hayes, Petia Kovatcheva-Datchary, Fredrik Bäckhed, J. A. Gilbert, , Jr. Lowe W.L, B. T. Layden
American Journal of Physiology. Endocrinology and Metabolism - 2015 -
Dietary Fiber-Induced Improvement in Glucose Metabolism Is Associated with Increased Abundance of
Prevotella
Petia Kovatcheva-Datchary, A. Nilsson, Rozita Akrami, Ying Shiuan Lee, Filipe De Vadder, Tulika Arora, Anna Hallén, E. Martens, I. Bjorck, Fredrik Bäckhed
Cell Metabolism - 2015 -
Crosstalk between gut microbiota and dietary lipids aggravates WAT inflammation through TLR
signaling
Robert Caesar, Valentina Tremaroli, Petia Kovatcheva-Datchary, P. D. Cani, Fredrik Bäckhed
Cell Metabolism - 2015 -
Oral microbiota in patients with
atherosclerosis
Frida Fåk, Valentina Tremaroli, Göran Bergström, Fredrik Bäckhed
Atherosclerosis - 2015 -
Site-specific programming of the host epithelial transcriptome by the gut
microbiota
Felix Sommer, Intawat Nookaew, Nina Sommer, Per Fogelstrand, Fredrik Bäckhed
Genome Biology - 2015 -
A catalog of the mouse gut
metagenome
L. Xiao, Q. Feng, S. S. Liang, S. B. Sonne, Z. K. Xia, X. M. Qiu, X. P. Li, H. Long, J. F. Zhang, D. Y. Zhang, C. Liu, Z. W. Fang, J. Chou, J. Glanville, Q. Hao, D. Kotowska, C. Colding, T. R. Licht, D. H. Wu, J. Yu, J. J. Y. Sung, Q. Y. Liang, J. H. Li, H. J. Jia, Z. Lan, Valentina Tremaroli, P. Dworzynski, H. B. Nielsen, Fredrik Bäckhed, J. Dore, E. Le Chatelier, S. D. Ehrlich, J. C. Lin, M. Arumugam, J. Wang, L. Madsen, K. Kristiansen
Nature Biotechnology - 2015 -
Roux-en-Y Gastric Bypass Surgery Induces Early Plasma Metabolomic and Lipidomic Alterations in Humans Associated with Diabetes
Remission
Tulika Arora, V. Velagapudi, D. J. Pournaras, R. Welbourn, Carel W le Roux, M. Oresic, Fredrik Bäckhed
Plos One - 2015 -
Farnesoid X receptor inhibits glucagon-like peptide-1 production by enteroendocrine L
cells
M. S. Trabelsi, M. Daoudi, J. Prawitt, S. Ducastel, V. Touche, Sama I. Sayin, A. Perino, C. A. Brighton, Y. Sebti, J. Kluza, O. Briand, H. Dehondt, E. Vallez, E. Dorchies, G. Baud, V. Spinelli, N. Hennuyer, S. Caron, K. Bantubungi, R. Caiazzo, F. Reimann, P. Marchetti, P. Lefebvre, Fredrik Bäckhed, F. M. Gribble, K. Schoonjans, F. Pattou, A. Tailleux, B. Staels, S. Lestavel
Nature Communications - 2015 -
Dynamics and Stabilization of the Human Gut Microbiome during the First Year of
Life.
Fredrik Bäckhed, Josefine Roswall, Yangqing Peng, Qiang Feng, Huijue Jia, Petia Kovatcheva-Datchary, Yin Li, Yan Xia, Hailiang Xie, Huanzi Zhong, Muhammad Tanweer Khan, Jianfeng Zhang, Junhua Li, Liang Xiao, Jumana Al-Aama, Dongya Zhang, Ying Shiuan Lee, Dorota Kotowska, Camilla Colding, Valentina Tremaroli, Ye Yin, Stefan Bergman, Xun Xu, Lise Madsen, Karsten Kristiansen, Jovanna Dahlgren, Jun Wang
Cell host & microbe - 2015 -
Genetic Disruption of Protein Kinase STK25 Ameliorates Metabolic Defects in a Diet-Induced Type 2 Diabetes
Model
Manoj Amrutkar, Emmelie Cansby, Urszula Chursa, Esther Nuñez Durán, Belén Chanclón, Marcus Ståhlman, Vincent Fridén, Louise Mannerås Holm, Anna Wickman, Ulf Smith, Fredrik Bäckhed, Jan Borén, B. W. Howell, Margit Mahlapuu
Diabetes - 2015 -
The gut microbiota engages different signaling pathways to induce Duox2 expression in the ileum and colon
epithelium
Felix Sommer, Fredrik Bäckhed
Mucosal Immunology - 2015 -
Insights Into the Role of the Microbiome in Obesity and Type 2
Diabetes
A. V. Hartstra, K. E. C. Bouter, Fredrik Bäckhed, Max Nieuwdorp
Diabetes Care - 2015 -
Altered mucus glycosylation in core 1 O-glycan-deficient mice affects microbiota composition and intestinal
architecture.
Felix Sommer, Nina Adam, Malin E V Johansson, Lijun Xia, Gunnar C. Hansson, Fredrik Bäckhed
PloS one - 2014 -
Microbiota-Generated Metabolites Promote Metabolic Benefits via Gut-Brain Neural
Circuits
Filipe De Vadder, Petia Kovatcheva-Datchary, Daisy Goncalves, Jennifer Vinera, Carine Zitoun, Adeline Duchampt, Fredrik Bäckhed, Gilles Mithieux
Cell - 2014 -
Microbiome of prebiotic-treated mice reveals novel targets involved in host response during
obesity
A. Everard, V. Lazarevic, N. Gaia, Maria Johansson, Marcus Ståhlman, Fredrik Bäckhed, N. M. Delzenne, J. Schrenzel, P. Francois, P. D. Cani
Isme Journal - 2014 -
The Gut Microbiota Modulates Glycaemic Control and Serum Metabolite Profiles in Non-Obese Diabetic
Mice
Thomas U. Greiner, T. Hyotylainen, M. Knip, Fredrik Bäckhed, M. Oresic
Plos One - 2014 -
Intestinal epithelial MyD88 is a sensor switching host metabolism towards obesity according to nutritional
status
A. Everard, L. Geurts, Robert Caesar, M. Van Hul, S. Matamoros, T. Duparc, R. G. P. Denis, P. Cochez, F. Pierard, J. Castel, L. B. Bindels, H. Plovier, S. Robine, G. G. Muccioli, J. C. Renauld, L. Dumoutier, N. M. Delzenne, S. Luquet, Fredrik Bäckhed, P. D. Cani
Nature Communications - 2014 -
Microbial Modulation of Insulin
Sensitivity
M. T. Khan, Max Nieuwdorp, Fredrik Bäckhed
Cell Metabolism - 2014 -
TRIF Signaling Drives Homeostatic Intestinal Epithelial Antimicrobial Peptide
Expression
S. Stockinger, C. U. Duerr, M. Fulde, T. Dolowschiak, J. Pott, I. Yang, D. Eibach, Fredrik Bäckhed, S. Akira, S. Suerbaum, M. Brugman, M. W. Hornef
Journal of Immunology - 2014 -
Intestinal permeability, gut-bacterial dysbiosis, and behavioral markers of alcohol-dependence
severity
S. Leclercq, S. Matamoros, P. D. Cani, A. M. Neyrinck, F. Jamar, P. Starkel, K. Windey, Valentina Tremaroli, Fredrik Bäckhed, K. Verbeke, P. de Timary, N. M. Delzenne
Proceedings of the National Academy of Sciences of the United States of America - 2014 -
Microbial-induced meprin β cleavage in MUC2 mucin and a functional CFTR channel are required to release anchored small intestinal
mucus
André Schütte, Anna Ermund, C. Becker-Pauly, Malin E V Johansson, Ana María Rodríguez-Piñeiro, Fredrik Bäckhed, S.C. Müller, D. Lottaz, J.S. Bond, Gunnar C. Hansson
Proceedings of the National Academy of Sciences of the United States of America - 2014 -
FXR is a molecular target for the effects of vertical sleeve
gastrectomy
K. K. Ryan, Valentina Tremaroli, C. Clemmensen, Petia Kovatcheva-Datchary, A. Myronovych, R. Karns, H. E. Wilson-Perez, D. A. Sandoval, R. Kohli, Fredrik Bäckhed, R. J. Seeley
Nature - 2014 -
Assessing the human gut microbiota in metabolic
diseases.
Fredrik H. Karlsson, Valentina Tremaroli, Jens B. Nielsen, Fredrik Bäckhed
Diabetes - 2013 -
Gut metagenome in European women with normal, impaired and diabetic glucose
control
Fredrik H. Karlsson, Valentina Tremaroli, Intawat Nookaew, Göran Bergström, Carl Johan Behre, Björn Fagerberg, Jens B. Nielsen, Fredrik Bäckhed
Nature - 2013 -
Microbial modulation of energy availability in the colon regulates intestinal
transit.
Anita Wichmann, Ava Allahyar, Thomas U. Greiner, Hubert Plovier, Gunnel Östergren Lundén, Thomas Larsson, Daniel J Drucker, Nathalie M Delzenne, Patrice D Cani, Fredrik Bäckhed
Cell host & microbe - 2013 -
The gut microbiota reduces leptin sensitivity and the expression of the obesity-suppressing neuropeptides proglucagon (Gcg) and brain-derived neurotrophic factor (Bdnf) in the central nervous
system.
Erik Schéle, Louise Grahnemo, Fredrik Anesten, Anna Hallén, Fredrik Bäckhed, John-Olov Jansson
Endocrinology - 2013 -
The gut microbiota--masters of host development and
physiology.
Felix Sommer, Fredrik Bäckhed
Nature reviews. Microbiology - 2013 -
Inflammation- and tumor-induced anorexia and weight loss require MyD88 in hematopoietic/myeloid cells but not in brain endothelial or neural
cells.
Johan Ruud, Daniel Björk Wilhelms, Anna Nilsson, Anna Eskilsson, Yan-Juan Tang, Peter Ströhle, Robert Caesar, Markus Schwaninger, Thomas Wunderlich, Fredrik Bäckhed, David Engblom, Anders Blomqvist
FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 2013 -
The gut microbiota and mucosal homeostasis: colonized at birth or at adulthood, does it
matter?
Sahar El Aidy, Guido Hooiveld, Valentina Tremaroli, Fredrik Bäckhed, Michiel Kleerebezem
Gut microbes - 2013 -
Gut microbiota regulates bile acid metabolism by reducing the levels of tauro-beta-muricholic acid, a naturally occurring FXR
antagonist.
Sama I. Sayin, Annika Wahlström, Jenny Felin, Sirkku Jäntti, Hanns-Ulrich Marschall, Krister Bamberg, Bo Angelin, Tuulia Hyötyläinen, Matej Orešič, Fredrik Bäckhed
Cell metabolism - 2013 -
Age-dependent TLR3 expression of the intestinal epithelium contributes to rotavirus
susceptibility
Johanna Pott, Silvia Stockinger, Natalia Torow, Anna Smoczek, Cornelia Lindner, Gerald McInerney, Fredrik Bäckhed, Ulrich Baumann, Oliver Pabst, André Bleich, Mathias W. Hornef
PLoS Pathogens - 2012 -
Tissue factor and PAR1 promote microbiota-induced intestinal vascular
remodelling
Christopher Reinhardt, Mattias Bergentall, Thomas U. Greiner, Florence Schaffner, Gunnel Östergren Lundén, Lars C. Petersen, Wolfram Ruf, Fredrik Bäckhed
Nature - 2012 -
Infection regulates pro-resolving mediators that lower antibiotic
requirements
Nan Chiang, Gabrielle Fredman, Fredrik Bäckhed, Sungwhan F. Oh, Thad Vickery, Birgitta A. Schmidt, Charles N. Serhan
Nature - 2012 -
Milk modulates the
microbiota
Fredrik Bäckhed, J. K. Nicholson
Nature Medicine - 2012 -
Analysis of gut microbial regulation of host gene expression along the length of the gut and regulation of gut microbial ecology through
MyD88
Erik Larsson, Valentina Tremaroli, Ying Shiuan Lee, Omry Koren, Intawat Nookaew, Ashwana Fricker, Jens B. Nielsen, Ruth E Ley, Fredrik Bäckhed
Gut - 2012 -
Symptomatic atherosclerosis is associated with an altered gut
metagenome
Fredrik H. Karlsson, Frida Fåk, Intawat Nookaew, Valentina Tremaroli, Björn Fagerberg, Dina Petranovic, Fredrik Bäckhed, Jens B. Nielsen
Nature Communications - 2012 -
Defining a Healthy Human Gut Microbiome: Current Concepts, Future Directions, and Clinical
Applications
Fredrik Bäckhed, C. M. Fraser, Y. Ringel, M. E. Sanders, R. B. Sartor, P. M. Sherman, J. Versalovic, V. Young, B. B. Finlay
Cell Host & Microbe - 2012 -
The gut microbiota regulates bone mass in
mice
Klara Sjögren, Cecilia Engdahl, Petra Henning, Ulf H Lerner, Valentina Tremaroli, Marie Lagerquist, Fredrik Bäckhed, Claes Ohlsson
Journal of Bone and Mineral Research - 2012 -
Gut-derived lipopolysaccharide augments adipose macrophage accumulation but is not essential for impaired glucose or insulin tolerance in
mice
Robert Caesar, Christopher S. Reigstad, Helene Kling Bäckhed, Christopher Reinhardt, Maria Ketonen, Gunnel Östergren Lundén, Patrice D. Cani, Fredrik Bäckhed
Gut - 2012 -
Lactobacillus reuteri Prevents Diet-Induced Obesity, but not Atherosclerosis, in a Strain Dependent Fashion in Apoe-/-
Mice
Frida Fåk, Fredrik Bäckhed
Plos One - 2012 -
Host Remodeling of the Gut Microbiome and Metabolic Changes during
Pregnancy
O. Koren, J. K. Goodrich, T. C. Cullender, A. Spor, K. Laitinen, Helene Kling Bäckhed, A. Gonzalez, J. J. Werner, L. T. Angenent, R. Knight, Fredrik Bäckhed, E. Isolauri, S. Salminen, R. E. Ley
Cell - 2012 -
Functional interactions between the gut microbiota and host
metabolism
Valentina Tremaroli, Fredrik Bäckhed
Nature - 2012 -
Host responses to the human
microbiome
Fredrik Bäckhed
Nutrition Reviews - 2012 -
Expression of the blood-group-related glycosyltransferase B4galnt2 influences the intestinal microbiota in
mice
F. Staubach, S. Kunzel, A. C. Baines, A. Yee, B. M. McGee, Fredrik Bäckhed, J. F. Baines, J. M. Johnsen
Isme Journal - 2012 -
Effects of the gut microbiota on obesity and glucose
homeostasis.
Thomas U. Greiner, Fredrik Bäckhed
Trends in endocrinology and metabolism: TEM - 2011 -
Targeting gut microbiota in obesity: effects of prebiotics and
probiotics
Nathalie Delzenne, Audrey Neyrinck, Fredrik Bäckhed, Patrice Cani
Nature reviews. Endocrinology - 2011 -
Intestinal Permeability Is Associated With Visceral Adiposity in Healthy
Women.
Anders Gummesson, Lena M S Carlsson, Len H Storlien, Fredrik Bäckhed, Pål Lundin, Lars Löfgren, Kaj Stenlöf, Yan Y Lam, Björn Fagerberg, Björn Carlsson
Obesity (Silver Spring, Md.) - 2011 -
Programming of host metabolism by the gut
microbiota.
Fredrik Bäckhed
Annals of nutrition & metabolism - 2011 -
Microbes and Health Sackler Colloquium: Human oral, gut, and plaque microbiota in patients with
atherosclerosis.
Omry Koren, Aymé Spor, Jenny Felin, Frida Fåk, Jesse Stombaugh, Valentina Tremaroli, Carl Johan Behre, Rob Knight, Björn Fagerberg, Ruth E Ley, Fredrik Bäckhed
Proceedings of the National Academy of Sciences of the United States of America - 2011 -
Coordinated regulation of the metabolome and lipidome at the host-microbial
interface
Fredrik Bäckhed, P. A. Crawford
Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids - 2010 -
The endocannabinoid system links gut microbiota to
adipogenesis.
Giulio G Muccioli, Damien Naslain, Fredrik Bäckhed, Christopher S. Reigstad, Didier M Lambert, Nathalie M Delzenne, Patrice D Cani
Molecular systems biology - 2010 -
Addressing the gut microbiome and implications for
obesity
Fredrik Bäckhed
INTERNATIONAL DAIRY JOURNAL - 2010 -
Microbial regulation of SAA3 expression in mouse colon and adipose
tissue.
Christopher S. Reigstad, Fredrik Bäckhed
Gut microbes - 2010 -
Effects of gut microbiota on obesity and atherosclerosis via modulation of inflammation and lipid
metabolism.
R Caesar, Frida Fåk, Fredrik Bäckhed
Journal of internal medicine - 2010 -
Deletion of the gene encoding MyD88 protects from anorexia in a mouse tumor
model.
Johan Ruud, Fredrik Bäckhed, David Engblom, Anders Blomqvist
Brain, behavior, and immunity - 2010 -
99th Dahlem conference on infection, inflammation and chronic inflammatory disorders: the normal gut microbiota in health and
disease.
Fredrik Bäckhed
Clinical and experimental immunology - 2010 -
A role for the gut microbiota in energy
harvesting?
Valentina Tremaroli, Petia Kovatcheva-Datchary, Fredrik Bäckhed
Gut - 2010 -
The gut microbiota modulates host energy and lipid metabolism in
mice
Vidya R. Velagapudi, Rahil Hezaveh, Christopher S. Reigstad, Peddinti V. Gopalacharyulu, Laxman Yetukuri, Sama Islam, Jenny Felin, Rosie Perkins, Jan Borén, Matej Oresic, Fredrik Bäckhed
Journal of Lipid Research - 2009 -
Intestinal microbiota during infancy and its implications for
obesity
Christopher Reinhardt, Christopher S. Reigstad, Fredrik Bäckhed
Journal of Pediatric Gastroenterology and Nutrition - 2009 -
Regulation of serum amyloid A3 (SAA3) in mouse colonic epithelium and adipose tissue by the intestinal
microbiota
Christopher S. Reigstad, G. O. Lunden, Jenny Felin, Fredrik Bäckhed
PLoS ONE - 2009 -
Oxidation-specific epitopes are dominant targets of innate natural antibodies in mice and
humans.
Meng-Yun Chou, Linda Fogelstrand, Karsten Hartvigsen, Lotte F Hansen, Douglas Woelkers, Peter X Shaw, Jeomil Choi, Thomas Perkmann, Fredrik Bäckhed, Yury I Miller, Sohvi Hörkkö, Maripat Corr, Joseph L Witztum, Christoph J Binder
The Journal of clinical investigation - 2009 -
Changes in intestinal microflora in obesity: cause or
consequence?
Fredrik Bäckhed
J Pediatr Gastroenterol Nutr - 2009 -
Angiopoietin-like 4 (ANGPTL4, fasting-induced adipose factor) is a direct glucocorticoid receptor target and participates in glucocorticoid-regulated triglyceride
metabolism
S. K. Koliwad, T. Kuo, L. E. Shipp, N. E. Gray, Fredrik Bäckhed, A. Y. So, R. V., Jr. Farese, J. C. Wang
J Biol Chem - 2009 -
Gut microbiota affects lens and retinal lipid
composition
M. Oresic, T. Seppanen-Laakso, L. Yetukuri, Fredrik Bäckhed, V. Hanninen
Exp Eye Res - 2009 -
Comparative analysis of human gut microbiota by barcoded
pyrosequencing
A. F. Andersson, M. Lindberg, H. Jakobsson, Fredrik Bäckhed, P. Nyren, L. Engstrand
PLoS ONE - 2008 -
Effects of the gut microbiota on host adiposity are modulated by the short-chain fatty-acid binding G protein-coupled receptor,
Gpr41
B. S. Samuel, A. Shaito, T. Motoike, F. E. Rey, Fredrik Bäckhed, J. K. Manchester, R. E. Hammer, S. C. Williams, J. Crowley, M. Yanagisawa, J. I. Gordon
Proceedings of the National Academy of Sciences of the United States of America - 2008 -
Diet-induced obesity is linked to marked but reversible alterations in the mouse distal gut
microbiome
P. J. Turnbaugh, Fredrik Bäckhed, L. Fulton, J. I. Gordon
Cell Host & Microbe - 2008 -
Mechanisms underlying the resistance to diet-induced obesity in germ-free
mice
Fredrik Bäckhed, J. K. Manchester, C. F. Semenkovich, J. I. Gordon
Proc Natl Acad Sci U S A - 2007 -
Role of the Lipopolysaccharide-CD14 Complex for the Activity of Hemolysin from Uropathogenic Escherichia
coli
Lisa E. Månsson, Peter Kjäll, Shahaireen Pellett, Gabor Nagy, Rodney A. Welch, Fredrik Bäckhed, Teresa Frisan, Agneta Richter-Dahlfors
Infect. Immun. - 2007 -
Postnatal lymphatic partitioning from the blood vasculature in the small intestine requires fasting-induced adipose
factor
Fredrik Bäckhed, P. A. Crawford, D. O'Donnell, J. I. Gordon
Proc Natl Acad Sci U S A - 2007 -
Linkage between cellular communications, energy utilization, and proliferation in metastatic neuroendocrine
cancers
J. E. Ippolito, M. E. Merritt, Fredrik Bäckhed, K. L. Moulder, S. Mennerick, J. K. Manchester, S. T. Gammon, D. Piwnica-Worms, J. I. Gordon
Proc Natl Acad Sci U S A - 2006 -
Linkage between cellular communications, energy utilization, and proliferation in metastatic neuroendocrine
cancers
J. E. Ippolito, M. E. Merritt, Fredrik Bäckhed, K. L. Moulder, S. Mennerick, J. K. Manchester, S. T. Gammon, D. Piwnica-Worms, J. I. Gordon
Proc Natl Acad Sci U S A - 2006 -
Host-bacterial mutualism in the human
intestine
Fredrik Bäckhed, R. E. Ley, J. L. Sonnenburg, D. A. Peterson, J. I. Gordon
Science - 2005 -
Obesity alters gut microbial
ecology
R. E. Ley, Fredrik Bäckhed, P. Turnbaugh, C. A. Lozupone, R. D. Knight, J. I. Gordon
Proc Natl Acad Sci U S A - 2005 -
The gut microbiota as an environmental factor that regulates fat
storage
Fredrik Bäckhed, H. Ding, T. Wang, L. V. Hooper, G. Y. Koh, A. Nagy, C. F. Semenkovich, J. I. Gordon
Proc Natl Acad Sci U S A - 2004 -
Nanoscale features influence epithelial cell morphology and cytokine
production
A. S. Andersson, Fredrik Bäckhed, A. von Euler, A. Richter-Dahlfors, D. Sutherland, B. Kasemo
Biomaterials - 2003 -
Toll-like receptor 4-mediated signaling by epithelial surfaces: necessity or
threat?
Fredrik Bäckhed, M. Hornef
Microbes Infect - 2003 -
Structural requirements for TLR4-mediated LPS signalling: a biological role for LPS
modifications
Fredrik Bäckhed, S. Normark, E. K. Schweda, S. Oscarson, A. Richter-Dahlfors
Microbes Infect - 2003 -
Helicobacter pylori infection induces interleukin-8 receptor expression in the human gastric
epithelium
Fredrik Bäckhed, E. Torstensson, D. Seguin, A. Richter-Dahlfors, B. Rokbi
Infect Immun - 2003 -
Gastric mucosal recognition of Helicobacter pylori is independent of Toll-like receptor
4
Fredrik Bäckhed, B. Rokbi, E. Torstensson, Y. Zhao, C. Nilsson, D. Seguin, S. Normark, A. M. Buchan, A. Richter-Dahlfors
J Infect Dis - 2003 -
Identification of target tissue glycosphingolipid receptors for uropathogenic, F1C-fimbriated Escherichia coli and its role in mucosal
inflammation
Fredrik Bäckhed, B. Alsen, N. Roche, J. Angstrom, A. von Euler, Michael Breimer, B. Westerlund-Wikstrom, Susann Teneberg, A. Richter-Dahlfors
Journal of Biological Chemistry - 2002 -
TLR4-dependent lipopolysaccharide signalling in epithelial cells is independent of extracellular protease
activity.
Fredrik Bäckhed, Staffan Normark, Agneta Richter-Dahlfors
Cellular microbiology - 2002 -
TLR4-dependent recognition of lipopolysaccharide by epithelial cells requires
sCD14
Fredrik Bäckhed, L. Meijer, S. Normark, A. Richter-Dahlfors
Cell Microbiol - 2002 -
Induction of innate immune responses by Escherichia coli and purified lipopolysaccharide correlate with organ- and cell-specific expression of Toll-like receptors within the human urinary
tract
Fredrik Bäckhed, M. Soderhall, P. Ekman, S. Normark, A. Richter-Dahlfors
Cell Microbiol - 2001 -
Alpha-haemolysin of uropathogenic E. coli induces Ca2+ oscillations in renal epithelial
cells
P. Uhlen, A. Laestadius, T. Jahnukainen, T. Soderblom, Fredrik Bäckhed, G. Celsi, H. Brismar, S. Normark, A. Aperia, A. Richter-Dahlfors
Nature - 2000