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Michael Breimer
Senior Advisor
Department of SurgeryAbout Michael Breimer
Michael Breimer received his MD at the Medical Faculty, Gothenburg University, in 1976. He passed his PhD examination in 1980, and became associate professor in Medical and Physiological Chemistry in 1982. In 2001, he was appointed full professor/consultant surgeon at the Department of Surgery, Sahlgrenska Academy/Sahlgrenska University Hospital, Gothenburg. He was a visiting INSERM researcher at the Institute de Biologie, Universite de Nantes, Nantes, France, in 1991-2, and visiting professor and consultant surgeon in renal transplantation surgery at Queen Elizabeth Hospital, Birmingham, UK, in 2003-4. Michael Breimer started his research in the Department of Medical and Physiological Chemistry isolating and structurally characterising blood group AB(O)H and related carbohydrate antigens. After his PhD examination, his biochemical studies relating to ABO-incompatible organ transplantation continued in the Department of Surgery. Studies of human kidneys/urinary tract revealed that human kidney contained a new type of blood group A structure. Blood group phenotypes relating to expression of ABO antigens in individual kidneys were identified. Based on A antigen expression, a hypothesis explaining why blood group A2 kidneys could be successfully transplanted to O recipients was postulated. Patients receiving ABO-incompatible kidney grafts were shown to elicit an individual specific response regarding antibody class and subclass. He was responsible for the clinical evalutation of a new blood group A/B saccharide-based immunoadsorption column. These results have been applied in clinical practice to establish ABO-incompatible renal and liver transplantation programs in Gothenburg and Birmingham, UK. The similarity between hyperacute rejection of ABO-incompatible allografts and xenografts initiated his xenotransplantation research. Carbohydrate xenoantigens and xenoantibody epitope-specificity, the removal of xenoantibodies by plasmapheresis, and antibody neutralization using soluble saccharides, were all explored. A pig kidney in vitro perfusion model was established. In 1995, he was one of the leading scientists conducting the clinical trial in which pig kidneys were connected extracorporeally to the blood circulation of volunteer dialysis patients. During more recent years, his reseach has been conducted in the field of regenerative medicine, focussed on antigen expression and immune recognition of human embryonic stem cells and bioartificial heart valves, the latter tissues being of animal origin. He has published more than 150 scientific articles in the fields of carbohydrate biochemistry, glycobiology, allo- and xeno-transplantation, and regeneratvie medicine. In the xenotransplantation field, he has undertaken several international scientific assignments, e.g., as a plenary speaker, member of editorial boards, as a Councillor of the International Xenotransplantation Association (IXA, 2000-2003 and 2013-2015). He was chairman of the organizing committee of the 8th congress of the IXA and its satellite meeting (2nd International symposium on ABO-incompatibility in transplantation) held in Gothenburg in 2005.
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Identification by mass spectrometry and immunoblotting of xenogeneic antigens in theN- andO-glycomes of porcine, bovine and equine heart
tissues
Chunsheng Jin, Reeja Maria Cherian, Jining Liu, Heribert Playà-Albinyana, C. Galli, Niclas G. Karlsson, Michael Breimer, Jan Holgersson
Glycoconjugate Journal - 2020 -
The Structural Complexity and Animal Tissue Distribution of N-Glycolylneuraminic Acid (Neu5Gc)-Terminated Glycans. Implications for Their Immunogenicity in Clinical
Xenografting
Michael Breimer, Jan Holgersson
Frontiers in Molecular Biosciences - 2019 -
Glycosphingolipids of porcine, bovine, and equine pericardia as potential immune targets in bioprosthetic heart valve
grafts
Angela Barone, John Benktander, Christy Whiddon, Chunsheng Jin, C. Galli, Susann Teneberg, Michael Breimer
Xenotransplantation - 2018 -
Is sensitization to pig antigens detrimental to subsequent
allotransplantation?
Q. Li, H. Hara, Z. Q. Zhang, Michael Breimer, Y. Wang, D. K. C. Cooper, Immunology Lettersmeeting On Advances In Transplantation Immunology Sep Aberdeen Scotland V. P. Irns Tdh, Transplantation Proceedings V. P. Lne Ry
Xenotransplantation - 2018 -
HLA and Histo-Blood Group Antigen Expression in Human Pluripotent Stem Cells and their
Derivatives
Karin Säljö, Angela Barone, Johan Mölne, Lennart Rydberg, Susann Teneberg, Michael Breimer
Scientific Reports - 2017 -
Comparison of the glycosphingolipids of human induced pluripotent stem cells and human embryonic stem
cells
Karin Säljö, Angela Barone, Dzeneta Vizlin-Hodzic, Bengt R Johansson, Michael Breimer, Keiko Funa, Susann Teneberg
Glycobiology - 2017 -
Glycosphingolipids of human embryonic stem
cells.
Michael Breimer, Karin Säljö, Angela Barone, Susann Teneberg
Glycoconjugate journal - 2017 -
Characterization of immunogenic Neu5Gc in bioprosthetic heart
valves
E. M. Reuven, S. Leviatan Ben-Arye, T. Marshanski, Michael Breimer, H. Yu, I. Fellah-Hebia, J. C. Roussel, C. Costa, M. Galiñanes, R. Mañez, T. Le Tourneau, J. P. Soulillou, E. Cozzi, X. Chen, V. Padler-Karavani
Xenotransplantation - 2016 -
Immunohistochemical Studies on Galectin Expression in Colectomised Patients with Ulcerative
Colitis.
Mattias Block, Johan Mölne, Hakon Leffler, Lars Börjesson, Michael Breimer
BioMed research international - 2016 -
A positive pre-transplant endothelial precursor cell crossmatch does not imply reduced long-term kindney graft
function
Markus Gäbel, Ayeda AlMahri, Lennart Rydberg, Jan Holgersson, Michael Breimer
SOJ Immunology - 2015 -
Recent investigations into pig antigen and anti-pig antibody
expression.
Guerard W Byrne, Christopher G A McGregor, Michael Breimer
International journal of surgery (London, England) - 2015 -
Bortezomib, C1-Inhibitor and Plasma Exchange Do Not Prolong the Survival of Multi-Transgenic GalT-KO Pig Kidney Xenografts in
Baboons.
S Le Bas-Bernardet, X Tillou, J Branchereau, N Dilek, N Poirier, M Châtelais, B Charreau, D Minault, J Hervouet, K Renaudin, C Crossan, L Scobie, Y Takeuchi, Mette Diswall, Michael Breimer, N Klar, M R Daha, P Simioni, S C Robson, M B Nottle, E J Salvaris, P J Cowan, A J F d'Apice, D H Sachs, K Yamada, I Lagutina, R Duchi, A Perota, G Lazzari, C Galli, E Cozzi, J-P Soulillou, B Vanhove, G Blancho
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons - 2015 -
Sialyl-lactotetra, a novel cell surface marker of undifferentiated human pluripotent stem
cells.
Angela Barone, Karin Säljö, Maria K. Blomqvist, Jan-Eric Månsson, Bengt R Johansson, Johan Mölne, John Benktander, Anders Aspegren, Petter Björquist, Michael Breimer, Susann Teneberg
Journal of Biological Chemistry - 2014 -
Characterization of acid and non-acid glycosphingolipids of porcine heart valve cusps as potential immune targets in biological heart valve
grafts.
Angela Barone, John Benktander, Susann Teneberg, Michael Breimer
Xenotransplantation - 2014 -
Tribute to Carl-Gustav Groth (1933-2014), first president of the International Xenotransplantation
Association.
David K C Cooper, Leo Buhler, Michael Breimer, Olle Korsgren, Annika Tibell, Lars Wennberg, Emanuele Cozzi, Anthony J F d'Apice, Bernhard Hering, Ian F C McKenzie, Richard N Pierson, Megan Sykes, Takaaki Kobayashi
Xenotransplantation - 2014 -
The alpha1,3GalT knockout/alpha1,2FucT transgenic pig does not appear to have an advantage over the alpha1,3GalT knockout pig with respect to glycolipid reactivity with human serum
antibodies.
Mette Diswall, John Benktander, Jonas Ångström, Susann Teneberg, Michael Breimer
Xenotransplantation - 2014 -
Molecular Deciphering of the ABO System as a Basis for Novel Diagnostics and Therapeutics in ABO Incompatible
Transplantation.
Jan Holgersson, Lennart Rydberg, Michael Breimer
International Reviews of Immunology - 2014 -
Structural Complexity of Non-acid Glycosphingolipids in Human Embryonic Stem Cells Grown under Feeder-free
Conditions.
Angela Barone, John Benktander, Jonas Ångström, Anders Aspegren, Petter Björquist, Susann Teneberg, Michael Breimer
The Journal of biological chemistry - 2013 -
Glycoproteomic identification of galectin-3 and -8 ligands in bronchoalveolar lavage of mild asthmatics and healthy
subjects.
Cecilia Cederfur, Johan Malmström, Kristian Nihlberg, Mattias Block, Michael Breimer, Leif Bjermer, Gunilla Westergren-Thorsson, Hakon Leffler
Biochimica et biophysica acta - 2012 -
Glycosphingolipid composition of epithelial cells isolated along the villus axis of small intestine of a single human
individual.
Michael Breimer, Gunnar C. Hansson, Karl-Anders Karlsson, Göran Larson, Hakon Leffler
Glycobiology - 2012 -
Norovirus GII.4 Virus-like Particles Recognize Galactosylceramides in Domains of Planar Supported Lipid
Bilayers.
Marta Bally, Gustaf E Rydell, Raphael Zahn, Waqas Nasir, Christian Eggeling, Michael Breimer, Lennart Svensson, Fredrik Höök, Göran Larson
Angewandte Chemie International Edition - 2012 -
Redefinition of the carbohydrate binding specificity of Helicobacter pylori BabA
adhesin.
John Benktander, Jonas Ångström, Michael Breimer, Susann Teneberg
The Journal of biological chemistry - 2012 -
Mobility
rethought
LH Breimer, Michael Breimer, DD Breimer
Nature - 2011 -
The structural basis of blood group A-related glycolipids in an A3 red cell phenotype and potential explanation to a serological
phenomenon
Lola Svensson, Laura Bindila, Jonas Ångström, Bo Samuelsson, Michael Breimer, Lennart Rydberg, Stephan Henry
Glycobiology - 2011 -
Erythrocyte and Porcine Intestinal Glycosphingolipids Recognized by F4 Fimbriae of Enterotoxigenic Escherichia
coli.
Annelies Coddens, Erik Valis, John Benktander, Jonas Ångström, Michael Breimer, Eric Cox, Susann Teneberg
PloS One - 2011 -
Antigen-binding specificity of anti-αGal reagents determined by solid-phase glycolipid-binding assays. A complete lack of αGal glycolipid reactivity in α1,3GalT-KO pig small
intestine.
Mette Diswall, Anki Gustafsson, Jan Holgersson, Mauro S Sandrin, Michael Breimer
Xenotransplantation - 2011 -
Gal/non-Gal antigens in pig tissues and human non-Gal antibodies in the GalT-KO
era.
Michael Breimer
Xenotransplantation - 2011 -
Structural characterization of alpha1,3-galactosyltransferase knockout pig heart and kidney glycolipids and their reactivity with human and baboon
antibodies.
Mette Diswall, Jonas Ångström, Hasse Karlsson, Carol J Phelps, David Ayares, Susann Teneberg, Michael Breimer
Xenotransplantation - 2010 -
Preoperative radiotherapy and extracellular matrix remodeling in rectal mucosa and tumour matrix metalloproteinases and plasminogen
components.
Eva Angenete, Tom Öresland, Peter Falk, Michael Breimer, Ragnar Hultborn, Marie-Louise Ivarsson
Acta oncologica - 2009 -
Recognition of blood group ABH type 1 determinants by the FedF adhesin of F18-fimbriated Escherichia
coli.
Annelies Coddens, Mette Diswall, Jonas Ångström, Michael Breimer, Bruno Goddeeris, Eric Cox, Susann Teneberg
The Journal of biological chemistry - 2009 -
Multicenter evaluation of a novel endothelial cell crossmatch test in kidney
transplantation.
Michael Breimer, Lennart Rydberg, Annette M Jackson, Donna P Lucas, Andrea A Zachary, Joseph K Melancon, Jon Von Visger, Ronald Pelletier, Susan L Saidman, Winfred W Williams, Jan Holgersson, Gunnar Tydén, Göran K Klintmalm, Sonnya Coultrup, Suchitra Sumitran-Holgersson, Per Grufman
Transplantation - 2009 -
Studies of TGF-beta(1-3) in serosal fluid during abdominal surgery and their effect on in vitro human mesothelial cell
proliferation.
Peter Falk, Maria Bergström, Ingrid Palmgren, Lena Holmdahl, Michael Breimer, Marie-Louise Ivarsson
The Journal of surgical research - 2009 -
Blood group ABO antigen expression in human embryonic stem cells and in differentiated hepatocyte- and cardiomyocyte-like
cells.
Johan Mölne, Petter Björquist, Katarina Andersson, Mette Diswall, Anders Jeppsson, Valeri Strokan, Lennart Rydberg, Michael Breimer
Transplantation - 2008 -
Studies of Lewis antigens and H. pylori adhesion in CHO cell lines engineered to express Lewis b
determinants.
Jonas Löfling, Mette Diswall, Sara Eriksson, Thomas Borén, Michael Breimer, Jan Holgersson
Glycobiology - 2008 -
Glycolipid studies in small intestine and pancreas of alpha1,3-galactosyltransferase knockout miniature swine: alpha1,3GALT-KO animals lack alphaGAL antigens and contain novel blood group H
compounds.
Mette Diswall, Jonas Ångström, H-J Schuurman, F J M F Dor, Lennart Rydberg, Michael Breimer
Transplantation proceedings - 2008 -
ABO incompatible kidney transplantation:Overview and new
strategies.
G Norden, Michael Breimer
Trends in transplantation - 2007 -
Studies on glycolipid antigens in small intestine and pancreas from alpha1,3-galactosyltransferase knockout miniature
swine.
Mette Diswall, Jonas Ångström, Frank J M F Dor, Henk-Jan Schuurman, Lennart Rydberg, Michael Breimer
Transplantation - 2007 -
Successful ABO-incompatible liver transplantation using A2
donors
Ulrika Skogsberg, Michael Breimer, Styrbjörn Friman, Lars Mjörnstedt, J. Molne, Michael Olausson, L. Rydberg, Christian T. Svalander, L. Backman
Transplantation proceedings - 2006 -
Adult ABO-incompatible liver transplantation, using A and B
donors
Ulrika Skogsberg, Michael Breimer, Styrbjörn Friman, Lars Mjörnstedt, J. Molne, Michael Olausson, L. Rydberg, Christian T. Svalander, L. Backman
Xenotransplantation - 2006 -
Surmonter les barrières classiques des groupes sanguins ABO en transplantation d
òrgane.
Michael Breimer
Actualités néphrologiques. Flammarion Médicine-Sciences. - 2006 -
ABO-incompatible live donor renal transplantation using blood group A/B carbohydrate antigen immunoadsorption and anti-CD20 antibody
treatment.
Gunnela Nordén, David Briggs, Paul Cockwell, Graham Lipkin, Lars Mjörnstedt, Johan Mölne, Andrew Ready, Lennart Rydberg, Ola Samuelsson, Christian T. Svalander, Michael Breimer
Xenotransplantation - 2006 -
Blood group A and B antigen expression in human kidneys correlated to A1/A2/B, Lewis, and secretor
status.
Michael Breimer, Johan Mölne, Gunnela Nordén, Lennart Rydberg, G. Thiel, Christian T. Svalander
Transplantation - 2006 -
Carbohydrate-dependent inhibition of Helicobacter pylori colonization using porcine
milk
A. Gustafsson, A. Hultberg, R. Sjostrom, I. Kacskovics, Michael Breimer, T. Boren, L. Hammarstrom, Jan Holgersson
Glycobiology - 2006 -
Glomerular C3c deposition and intravascular macrophage accumulation in early humoral renal allograft rejection signifies a poor short-term
outcome.
Johan Mölne, Gudrun Nyberg, Ingemar Blohmé, Lennart Rydberg, Michael Breimer, Christian T. Svalander
APMIS : acta pathologica, microbiologica, et immunologica Scandinavica - 2006 -
[To have more physicians in executive functions requires changes in the curriculum of undergraduate medical
education]
Michael Breimer
Lakartidningen - 2006 -
Structural characterization of blood group A glycolipids in blood group A liver tissue in situ perfused with O blood: the dominating presence of type 1 core chain A
antigens.
Bo Samuelsson, Stefan Magnusson, Lennart Rydberg, Tore Scherstén, Michael Breimer
Xenotransplantation - 2006 -
Characteristics of protein-carbohydrate interactions as a basis for developing novel carbohydrate-based antirejection
therapies
Jan Holgersson, A. Gustafsson, Michael Breimer
Immunology and cell biology - 2005 -
Anti-pig antibody adsorption efficacy of {alpha}-Gal carrying recombinant P-selectin glycoprotein ligand-1/immunoglobulin chimeras increases with core 2 {beta}1, 6-N-acetylglucosaminyltransferase
expression
J. Liu, A. Gustafsson, Michael Breimer, A. Kussak, Jan Holgersson
Glycobiology - 2005 -
Carbohydrate phenotyping of human and animal milk
glycoproteins
A. Gustafsson, I. Kacskovics, Michael Breimer, L. Hammarstrom, Jan Holgersson
Glycoconjugate journal - 2005 -
Immunoperoxidase versus immunofluorescence in the assessment of human renal
biopsies.
Johan Mölne, Michael Breimer, Christian T. Svalander
American journal of kidney diseases : the official journal of the National Kidney Foundation - 2005
More publications
We have limited the number of publications on this page. Visit GUP (The Publication Database for Gothenburg University) to find more publications.