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- Malin Johansson
Malin Johansson
Professor
Department of Medical Biochemistry and Cell biologyAvd-/Sektionschef, Inst
Department of Medical Biochemistry and Cell biology-
The structure of FCGBP is formed as a disulfide-mediated homodimer between its C-terminal
domains
Erik Ehrencrona, Pablo Gallego, Sergio Trillo-Muyo, Maria-Jose Garcia-Bonete, Christian V Recktenwald, Gunnar C. Hansson, Malin E V Johansson
FEBS JOURNAL - 2025 -
Human milk oligosaccharide 2'-fucosyllactose protects against high-fat diet-induced obesity by changing intestinal mucus production, composition and degradation linked to changes in gut microbiota and faecal proteome profiles in
mice.
Paola Paone, Dimitris Latousakis, Romano Terrasi, Didier Vertommen, Ching Jian, Valentina Borlandelli, Francesco Suriano, Malin E V Johansson, Anthony Puel, Caroline Bouzin, Nathalie M. Delzenne, Anne Salonen, Nathalie Juge, Bogdan I. Florea, Giulio G. Muccioli, Herman Overkleeft, Matthias Van Hul, Patrice D. Cani
Gut - 2024 -
GLP-1R signaling modulates colonic energy metabolism, goblet cell number and survival in the absence of gut
microbiota
Thomas U. Greiner, Ara Koh, Eduard Peris, Mattias Bergentall, Malin E V Johansson, Gunnar C. Hansson, Daniel J. Drucker, Fredrik Bäckhed
MOLECULAR METABOLISM - 2024 -
The structure of the second CysD domain of MUC2 and role in mucin organization by transglutaminase-based
cross-linking
Christian V Recktenwald, Göran Karlsson, Maria-Jose Garcia-Bonete, Gergely Katona, Maja Jensen, Richard Lymer, Malin Bäckström, Malin E V Johansson, Gunnar C. Hansson, Sergio Trillo-Muyo
Cell Reports - 2024 -
Low-grade intestinal inflammation two decades after pelvic
radiotherapy.
Sravani Devarakonda, Annika Thorsell, Per Hedenström, Azar Rezapour, Lisen Heden, Sanghita Banerjee, Malin E V Johansson, George M. H. Birchenough, Amelie Toft Morén, Karin Gustavsson, Viktor Skokic, Victor L Pettersson, F. Sjöberg, Marie Kalm, Mohammad Al Masri, Michaela Ekh, Henrik Fagman, Mats Wolving, Rosie Perkins, Rodrigo A Morales, Francisca Castillo, Eduardo J Villablanca, Ulf Yrlid, Karin Bergmark, Gunnar Steineck, Cecilia Bull
EBioMedicine - 2023 -
The intestinal MUC2 mucin C-terminus is stabilized by an extra disulfide bond in comparison to von Willebrand factor and other gel-forming
mucins
Pablo Gallego, Maria-Jose Garcia-Bonete, Sergio Trillo-Muyo, Christian V Recktenwald, Malin E V Johansson, Gunnar C. Hansson
Nature communications - 2023 -
The role of goblet cells and mucus in intestinal
homeostasis
Jenny K Gustafsson, Malin E V Johansson
Nature Reviews Gastroenterology & Hepatology - 2022 -
Nociceptor neurons direct goblet cells via a CGRP-RAMP1 axis to drive mucus production and gut barrier
protection
D. P. Yang, A. Jacobson, K. A. Meerschaert, J. J. Sifakis, M. Wu, X. Chen, T. D. Yang, Y. L. Zhou, P. V. Anekal, R. A. Rucker, D. Sharma, A. Sontheimer-Phelps, G. S. Wu, L. W. Deng, M. D. Anderson, S. Choi, D. Neel, N. C. L. Lee, D. L. Kasper, B. Jabri, J. R. Huh, Malin E V Johansson, J. R. Thiagarajah, S. J. Riesenfeld, I. M. Chiu
Cell - 2022 -
Clearance of small intestinal crypts involves goblet cell mucus secretion by intracellular granule rupture and enterocyte ion
transport
Brendan Dolan, Anna Ermund, Beatriz Martinez Abad, M Johansson, Gunnar C. Hansson
Science Signaling - 2022 -
Human intelectin-2 (ITLN2) is selectively expressed by secretory Paneth
cells
E. B. Nonnecke, P. A. Castillo, Malin E V Johansson, E. J. Hollox, B. Shen, B. Lönnerdal, C. L. Bevins
FASEB Journal - 2022 -
A fiber-rich diet and radiation-induced injury in the murine intestinal
mucosa
Dilip Malipatlolla, Sravani Devarakonda, Piyush Patel, Fei Sjöberg, A. Rascón, Rita Grandér, Viktor Skokic, Marie Kalm, Jolie Danial, Eva Mehdin, Malin Warholm, Henrietta Norling, A. Stringer, Malin E V Johansson, M. Nyman, Gunnar Steineck, Cecilia Bull
International Journal of Molecular Sciences - 2022 -
Transglutaminase 3 crosslinks the secreted gel-forming mucus component Mucin-2 and stabilizes the colonic mucus
layer
Jack D. A. Sharpen, Brendan Dolan, Elisabeth E. L. Nyström, George M. H. Birchenough, Liisa Arike, Beatriz Martinez Abad, Malin E V Johansson, Gunnar C. Hansson, Christian V Recktenwald
Nature Communications - 2022 -
Human intelectin-1 (ITLN1) genetic variation and intestinal
expression
E. B. Nonnecke, P. A. Castillo, A. E. Dugan, F. Almalki, M. A. Underwood, C. A. De La Motte, W. Yuan, W. Lu, B. Shen, Malin E V Johansson, L. L. Kiessling, E. J. Hollox, B. Lonnerdal, C. L. Bevins
Scientific Reports - 2021 -
The IgGFc-binding protein FCGBP is secreted with all GDPH sequences cleaved but maintained by interfragment disulfide
bonds
Erik Ehrencrona, Sjoerd van der Post, Pablo Gallego, Christian V Recktenwald, Ana Rodriguez-Piñeiro, Maria-Jose Garcia-Bonete, Sergio Trillo-Muyo, Malin Bäckström, Gunnar C. Hansson, Malin E V Johansson
Journal of Biological Chemistry - 2021 -
An intercrypt subpopulation of goblet cells is essential for colonic mucus barrier
function
Elisabeth E. L. Nyström, Beatriz Martinez Abad, Liisa Arike, George M. H. Birchenough, E. B. Nonnecke, P. A. Castillo, Frida Svensson, C. L. Bevins, Gunnar C. Hansson, Malin E V Johansson
Science - 2021 -
Forming a mucus barrier along the
colon
George M. H. Birchenough, Malin E V Johansson
Science - 2020 -
Protein Turnover in Epithelial Cells and Mucus along the Gastrointestinal Tract Is Coordinated by the Spatial Location and
Microbiota
Liisa Arike, A. Seiman, Sjoerd van der Post, Ana María Rodríguez-Piñeiro, Anna Ermund, André Schütte, Fredrik Bäckhed, Malin E V Johansson, Gunnar C. Hansson
Cell Reports - 2020 -
The Nlrp6 inflammasome is not required for baseline colonic inner mucus layer formation or
function
Joana K. Volk, Elisabeth E. L. Nyström, Sjoerd van der Post, Beatriz Martinez Abad, Björn O. Schröder, Åsa Johansson, Frida Svensson, Sofia Jäverfelt, Malin E V Johansson, Gunnar C. Hansson, George M. H. Birchenough
Journal of Experimental Medicine - 2019 -
Interleukin 4 induces rapid mucin transport, increases mucus thickness and quality and decreases colitis and Citrobacter rodentium in contact with epithelial
cells
Sinan Sharba, Nazanin Navabi, Médea Padra, Macarena P Quintana-Hayashi, Jenny K Gustafsson, Louis Szeponik, Vignesh Venkatakrishnan, A. Sjoling, Staffan Nilsson, Marianne Quiding-Järbrink, Malin E V Johansson, Sara K. Lindén
Virulence - 2019 -
Normal calcium-activated anion secretion in a mouse selectively lacking TMEM16A in intestinal
epithelium
Génesis Vega, Anita Guequén, Malin E V Johansson, Liisa Arike, Beatriz Martinez Abad, Elisabeth E. L. Nyström, Paolo Scudieri, Nicoletta Pedemonte, Pamela Millar-Büchner, Amber R. Philp, Luis J. Galietta, Gunnar C. Hansson, Carlos A. Flores
Frontiers in Physiology - 2019 -
Potential roles of gut microbiome and metabolites in modulating ALS in
mice
E. Blacher, S. Bashiardes, H. Shapiro, D. Rothschild, U. Mor, M. Dori-Bachash, C. Kleimeyer, C. Moresi, Y. Harnik, M. Zur, M. Zabari, R. B. Z. Brik, D. Kviatcovsky, N. Zmora, Y. Cohen, N. Bar, I. Levi, N. Amar, T. Mehlman, A. Brandis, I. Biton, Y. Kuperman, M. Tsoory, L. Alfahel, A. Harmelin, M. Schwartz, A. Israelson, Liisa Arike, Malin E V Johansson, Gunnar C. Hansson, M. Gotkine, E. Segal, E. Elinav
Nature - 2019 -
Structural weakening of the colonic mucus barrier is an early event in ulcerative colitis
pathogenesis
Sjoerd van der Post, Karolina S. Jabbar, George M. H. Birchenough, Liisa Arike, Noreen Akhtar, Henrik Sjövall, Malin E V Johansson, Gunnar C. Hansson
Gut - 2019 -
Calcium-activated chloride channel regulator 1 (CLCA1) forms non-covalent oligomers in colonic mucus and has mucin 2-processing
properties
Elisabeth E. L. Nyström, Liisa Arike, Erik Ehrencrona, Gunnar C. Hansson, Malin E V Johansson
Journal of Biological Chemistry - 2019 -
Bifidobacteria or Fiber Protects against Diet-Induced Microbiota-Mediated Colonic Mucus
Deterioration
Björn O. Schröder, George M. H. Birchenough, Marcus Ståhlman, Liisa Arike, Malin E V Johansson, Gunnar C. Hansson, Fredrik Bäckhed
Cell Host & Microbe - 2018 -
The central exons of the human MUC2 and MUC6 mucins are highly repetitive and variable in sequence between
individuals
Frida Svensson, T. G. Lang, Malin E V Johansson, Gunnar C. Hansson
Scientific Reports - 2018 -
Calcium-activated Chloride Channel Regulator 1 (CLCA1) Controls Mucus Expansion in Colon by Proteolytic
Activity
Elisabeth E. L. Nyström, George M. H. Birchenough, Sjoerd van der Post, Liisa Arike, A. D. Gruber, Gunnar C. Hansson, Malin E V Johansson
Ebiomedicine - 2018 -
Study of mucin turnover in the small intestine by in vivo
labeling
Hannah Schneider, Thaher Pelaseyed, Frida Svensson, Malin E V Johansson
Scientific Reports - 2018 -
Core 1- and 3-derived O-glycans collectively maintain the colonic mucus barrier and protect against spontaneous colitis in
mice.
K Bergstrom, J Fu, Malin E V Johansson, X Liu, N Gao, Q Wu, J Song, J M McDaniel, S McGee, W Chen, J Braun, Gunnar C. Hansson, L Xia
Mucosal immunology - 2017 -
Postnatal development of the small intestinal mucosa drives age-dependent, regio-selective susceptibility to Escherichia coli K1
infection
George M. H. Birchenough, F. Dalgakiran, L. A. Witcomb, Malin E V Johansson, A. J. McCarthy, Gunnar C. Hansson, P. W. Taylor
Scientific Reports - 2017 -
Gram-positive bacteria are held at a distance in the colon mucus by the lectin-like protein
ZG16.
Joakim H. Bergström, George M. H. Birchenough, Gergely Katona, Björn O. Schröder, André Schütte, Anna Ermund, Malin E V Johansson, Gunnar C. Hansson
Proceedings of the National Academy of Sciences of the United States of America - 2016 -
Searching the Evolutionary Origin of Epithelial Mucus Protein Components-Mucins and
FCGBP
Tiange Lang, Sofia Klasson, Erik Larsson, Malin E V Johansson, Gunnar C. Hansson, Tore Samuelsson
Molecular Biology and Evolution - 2016 -
A sentinel goblet cell guards the colonic crypt by triggering Nlrp6-dependent Muc2
secretion
George M. H. Birchenough, Elisabeth E. L. Nyström, Malin E V Johansson, Gunnar C. Hansson
Science - 2016 -
The
Mucins
Malin E V Johansson, Gunnar C. Hansson
Encyclopedia of Immunobiology - 2016 -
Immunological aspects of intestinal mucus and
mucins
Malin E V Johansson, Gunnar C. Hansson
Nature Reviews Immunology - 2016 -
The composition of the gut microbiota shapes the colon mucus
barrier.
Hedvig E Jakobsson, Ana María Rodríguez-Piñeiro, André Schütte, Anna Ermund, Preben Boysen, Mats Bemark, Felix Sommer, Fredrik Bäckhed, Gunnar C. Hansson, Malin E V Johansson
EMBO reports - 2015 -
Normalization of Host Intestinal Mucus Layers Requires Long-Term Microbial
Colonization
Malin E V Johansson, Hedvig E Jakobsson, Jessica Holmén Larsson, André Schütte, Anna Ermund, Ana María Rodríguez-Piñeiro, Liisa Arike, Catharina Wising, Frida Svensson, Fredrik Bäckhed, Gunnar C. Hansson
Cell Host & Microbe - 2015 -
Loss of NHE8 expression impairs intestinal mucosal
integrity
Aiping Wang, Jing Li, Yang Zhao, Malin E V Johansson, Hua Xu, Fayez K. Ghishan
American Journal of Physiology - Gastrointestinal and Liver Physiology - 2015 -
The colonic mucus protection depends on the
microbiota
Ana María Rodríguez-Piñeiro, Malin E V Johansson
Gut microbes - 2015 -
The Goblet Cell Protein Clca1 (Alias mClca3 or Gob-5) Is Not Required for Intestinal Mucus Synthesis, Structure and Barrier Function in Naive or DSS-Challenged
Mice
N. A. Erickson, Elisabeth E. L. Nyström, L. Mundhenk, Liisa Arike, R. Glauben, M. M. Heimesaat, A. Fischer, S. Bereswill, George M. H. Birchenough, A. D. Gruber, Malin E V Johansson
Plos One - 2015 -
New developments in goblet cell mucus secretion and
function
George M. H. Birchenough, Malin E V Johansson, Jenny K Gustafsson, Joakim H. Bergström, Gunnar C. Hansson
Mucosal Immunology - 2015 -
Bacteria penetrate the normally impenetrable inner colon mucus layer in both murine colitis models and patients with ulcerative
colitis.
Malin E V Johansson, Jenny K Gustafsson, Jessica Holmén Larsson, Karolina S. Jabbar, Lijun Xia, Hua Xu, Fayez K Ghishan, Frederic A Carvalho, Andrew T Gewirtz, Henrik Sjövall, Gunnar C. Hansson
Gut - 2014 -
The mucus and mucins of the goblet cells and enterocytes provide the first defense line of the gastrointestinal tract and interact with the immune
system
Thaher Pelaseyed, Joakim H. Bergström, Jenny K Gustafsson, Anna Ermund, George M. H. Birchenough, André Schütte, Sjoerd van der Post, Frida Svensson, Ana María Rodríguez-Piñeiro, Elisabeth E. L. Nyström, Catharina Wising, Malin E V Johansson, Gunnar C. Hansson
Immunological Reviews - 2014 -
Altered mucus glycosylation in core 1 O-glycan-deficient mice affects microbiota composition and intestinal
architecture.
Felix Sommer, Nina Adam, Malin E V Johansson, Lijun Xia, Gunnar C. Hansson, Fredrik Bäckhed
PloS one - 2014 -
Spontaneous colitis in Muc2-deficient mice reflects clinical and cellular features of active ulcerative
colitis.
Ulf Alexander Wenzel, Maria K Magnusson, Anna Rydström, Caroline Jonstrand, Julia Hengst, Malin E V Johansson, Anna Velcich, Lena Öhman, Hans Strid, Henrik Sjövall, Gunnar C. Hansson, Mary Jo Wick
PloS one - 2014 -
Is the intestinal goblet cell a major immune
cell?
Malin E V Johansson, Gunnar C. Hansson
Cell host & microbe - 2014 -
AGR2, an endoplasmic reticulum protein, is secreted into the gastrointestinal
mucus.
Joakim H. Bergström, Katarina A Berg, Ana María Rodríguez-Piñeiro, Bärbel Stecher, Malin E V Johansson, Gunnar C. Hansson
PloS one - 2014 -
Mucus Layers in Inflammatory Bowel
Disease
Malin E V Johansson
Inflammatory Bowel Diseases - 2014 -
Microbial-induced meprin β cleavage in MUC2 mucin and a functional CFTR channel are required to release anchored small intestinal
mucus
André Schütte, Anna Ermund, C. Becker-Pauly, Malin E V Johansson, Ana María Rodríguez-Piñeiro, Fredrik Bäckhed, S.C. Müller, D. Lottaz, J.S. Bond, Gunnar C. Hansson
Proceedings of the National Academy of Sciences of the United States of America - 2014 -
Slc26a3 deficiency is associated with loss of colonic HCO3 (-) secretion, absence of a firm mucus layer, and barrier impairment in
mice.
Fang Xiao, Qin Yu, Junhua Li, Malin E V Johansson, Anurag Kumar Singh, Weiliang Xia, Brigitte Riederer, Regina Engelhardt, Marshall Montrose, Manoocher Soleimani, De-An Tian, Gang Xu, Gunnar C. Hansson, Ursula Seidler
Acta physiologica (Oxford, England) - 2014 -
Site-specific O-glycosylation on the MUC2 mucin protein inhibits cleavage by the Porphyromonas gingivalis secreted cysteine protease
(RgpB).
Sjoerd van der Post, Durai B Subramani, Malin Bäckström, Malin E V Johansson, Malene B Vester-Christensen, Ulla Mandel, Eric P Bennett, Henrik Clausen, Gunnar Dahlén, Aneta Sroka, Jan Potempa, Gunnar C. Hansson
The Journal of biological chemistry - 2013
More publications
We have limited the number of publications on this page. Visit GUP (The Publication Database for Gothenburg University) to find more publications.