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Louise Grahnemo
Researcher
Department of Internal Medicine and ClinicalAbout Louise Grahnemo
In 2012, Louise joined CBAR (Centre for Bone and Arthritis Research) as a postdoc to study osteoporosis in an experimental model of arthritis. Louise is now associate professor in molecular medicine, and she now works with large datasets to determine the relationship between microbiota, body composition, fractures, and biomarkers.
PhD Students
- Sara Svahn (2010-2015): Effects of dietary fatty acids on the immune system (co-supervisor)
- Angelina Bernardi (2013-2015): Immune regulation by selective estrogen receptor modulators (co-supervisor)
- Johan Quester (2022-): Identification of causal risk factors for fractures and bone mineral density using Mendelian randomization (co-superviser)
-
Large-scale circulating proteome association study (CPAS) meta-analysis identifies circulating proteins and pathways predicting incident hip
fractures.
Thomas R Austin, Howard A Fink, Diana I Jalal, Anna E Törnqvist, Petra Buzkova, Joshua I Barzilay, Tianyuan Lu, Laura Carbone, Maiken E Gabrielsen, Louise Grahnemo, Kristian Hveem, Christian Jonasson, Jorge R Kizer, Arnulf Langhammer, Kenneth J Mukamal, Robert E Gerszten, Maria Nethander, Bruce M Psaty, John A Robbins, Yan V Sun, Anne Heidi Skogholt, Bjørn Olav Åsvold, Rodrigo J Valderrabano, Jie Zheng, J Brent Richards, Eivind Coward, Claes Ohlsson
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research - 2024 -
Low Circulating Valine Associate With High Risk of Hip
Fractures
Louise Grahnemo, Anna L Eriksson, Maria Nethander, R. Johansson, Mattias Lorentzon, Dan Mellström, U. Pettersson-Kymmer, Claes Ohlsson
Journal of Clinical Endocrinology & Metabolism - 2023 -
Identification of three bacterial species associated with increased appendicular lean mass: the HUNT
study
Louise Grahnemo, Maria Nethander, E. Coward, M. E. Gabrielsen, S. Sree, J. M. Billod, Klara Sjögren, L. Engstrand, K. F. Dekkers, T. Fall, A. Langhammer, K. Hveem, Claes Ohlsson
Nature Communications - 2023 -
Dietary Progesterone Contributes to Intratissue Levels of Progesterone in Male
Mice
Hannah Colldén, Malin Hagberg Thulin, A. Landin, Karin Horkeby, Marie Lagerquist, Jianyao Wu, Karin H. Nilsson, Louise Grahnemo, Matti Poutanen, H. Ryberg, Liesbeth Vandenput, Claes Ohlsson
Endocrinology - 2023 -
An atlas of genetic determinants of forearm
fracture.
Maria Nethander, Sofia Movérare-Skrtic, Anders Kämpe, Eivind Coward, Ene Reimann, Louise Grahnemo, Éva Borbély, Zsuzsanna Helyes, Thomas Funck-Brentano, Martine Cohen-Solal, Juha Tuukkanen, Antti Koskela, Jianyao Wu, Lei Li, Tianyuan Lu, Maiken E Gabrielsen, Reedik Mägi, Mari Hoff, Ulf H Lerner, Petra Henning, Henrik Ullum, Christian Erikstrup, Søren Brunak, Arnulf Langhammer, Tiinamaija Tuomi, Asmundur Oddsson, Kari Stefansson, Ulrika Pettersson-Kymmer, Sisse Rye Ostrowski, Ole Birger Vesterager Pedersen, Unnur Styrkarsdottir, Outi Mäkitie, Kristian Hveem, J Brent Richards, Claes Ohlsson
Nature genetics - 2023 -
Transplantation of gut microbiota from old mice into young healthy mice reduces lean mass but not bone
mass
Lina Lawenius, C. Cowardin, Louise Grahnemo, Julia Scheffler, Karin Horkeby, Cecilia Engdahl, Jianyao Wu, Liesbeth Vandenput, A. Koskela, J. Tukkanen, E. Coward, K. Hveem, A. Langhammer, Sanna Abrahamsson, J. I. Gordon, Klara Sjögren, Claes Ohlsson
Gut Microbes - 2023 -
Assessment of the genetic and clinical determinants of hip fracture risk: Genome-wide association and Mendelian randomization
study.
Maria Nethander, Eivind Coward, Ene Reimann, Louise Grahnemo, Maiken E Gabrielsen, Carl Wibom, Reedik Mägi, Thomas Funck-Brentano, Mari Hoff, Arnulf Langhammer, Ulrika Pettersson-Kymmer, Kristian Hveem, Claes Ohlsson
Cell reports. Medicine - 2022 -
Cross-sectional associations between the gut microbe Ruminococcus gnavus and features of the metabolic
syndrome.
Louise Grahnemo, Maria Nethander, Eivind Coward, Maiken Elvestad Gabrielsen, Satya Sree, Jean-Marc Billod, Lars Engstrand, Sanna Abrahamsson, Arnulf Langhammer, Kristian Hveem, Claes Ohlsson
The Lancet. Diabetes & endocrinology - 2022 -
A probiotic mix partially protects against castration-induced bone loss in male
mice
Lina Lawenius, Hannah Colldén, Karin L Horkeby, Jianyao Wu, Louise Grahnemo, Liesbeth Vandenput, Claes Ohlsson, Klara Sjögren
Journal of Endocrinology - 2022 -
Associations of Trabecular and Cortical Volumetric Bone Mineral Density With Coronary Artery Calcification Score: The Swedish Cardiopulmonary Bioimage Study Pilot
Study.
Thomas Funck-Brentano, Louise Grahnemo, Ola Hjelmgren, John Brandberg, Göran Bergström, Claes Ohlsson
JAMA cardiology - 2021 -
Acute fat loss does not affect bone
mass
Marie K Lagerquist, Karin L. Gustafsson, Petra Henning, Helen H. Farman, Jianyao Wu, Klara Sjögren, A. Koskela, J. Tuukkanen, Claes Ohlsson, Ingrid Wernstedt Asterholm, Louise Grahnemo
Scientific Reports - 2021 -
Wnt16 Overexpression in Osteoblasts Increases the Subchondral Bone Mass but has no Impact on Osteoarthritis in Young Adult Female
Mice
Anna E Törnqvist, Louise Grahnemo, Karin H. Nilsson, Thomas Funck-Brentano, Claes Ohlsson, Sofia Movérare-Skrtic
Calcified Tissue International - 2020 -
Interleukin 17A: a Janus-faced regulator of
osteoporosis
Julia M. Scheffler, Louise Grahnemo, Cecilia Engdahl, Christina Drevinge, Karin L. Gustafsson, Carmen Corciulo, Lina Lawenius, Y. Iwakura, Klara Sjögren, Marie Lagerquist, Hans Carlsten, Claes Ohlsson, Ulrika Islander
Scientific Reports - 2020 -
Osteoporosis in a murine model of postmenopausal
lupus
Jauqueline Nordqvist, Marie K Lagerquist, Louise Grahnemo, A. Koskela, Ulrika Islander, Hans Carlsten
Lupus - 2020 -
Spleen proteomics data from high fat diet fed
mice.
Sara L Svahn, Bagmi Pattanaik, Louise Grahnemo, Saray Gutiérrez, Intawat Nookaew, John-Olov Jansson, Maria E Johansson
Data in brief - 2020 -
Membrane estrogen receptor alpha is essential for estrogen signaling in the male
skeleton
Helen H. Farman, Karin L. Gustafsson, Petra Henning, Louise Grahnemo, Vikte Lionikaite, Sofia Moverare-Skrtic, Jianyao Wu, Henrik Ryberg, A. Koskela, J. Tuukkanen, E. R. Levin, Claes Ohlsson, Marie Lagerquist
Journal of Endocrinology - 2018 -
Increased bone mass in a mouse model with low fat
mass.
Louise Grahnemo, Karin L. Gustafsson, Klara Sjögren, Petra Henning, Vikte Lionikaite, Antti Koskela, Juha Tuukkanen, Claes Ohlsson, Ingrid Wernstedt Asterholm, Marie Lagerquist
American journal of physiology. Endocrinology and metabolism - 2018 -
Dietary Omega-3 Fatty Acids Increase Survival and Decrease Bacterial Load in Mice Subjected to Staphylococcus aureus-Induced
Sepsis
Sara L Svahn, Marcus A Ulleryd, Louise Grahnemo, Marcus Ståhlman, Jan Borén, Staffan Nilsson, John-Olov Jansson, Maria E Johansson
Infection and Immunity - 2016 -
Six Tissue Transcriptomics Reveals Specific Immune Suppression in Spleen by Dietary Polyunsaturated Fatty
Acids
Sara L Svahn, Leif Väremo, Britt G. Gabrielsson, Eduard Peris, Intawat Nookaew, Louise Grahnemo, Ann-Sofie Sandberg, Ingrid Wernstedt Asterholm, John-Olov Jansson, Jens B. Nielsen, Maria E Johansson
PLoS ONE - 2016 -
Regulation of body fat mass by the gut microbiota: Possible mediation by the
brain.
Erik Schéle, Louise Grahnemo, Fredrik Anesten, Anna Hallén, Fredrik Bäckhed, John-Olov Jansson
Peptides - 2016 -
Suppression of Experimental Arthritis and Associated Bone Loss by a Tissue-Selective Estrogen
Complex.
Annica Andersson, Angelina I Bernardi, Merja Nurkkala Karlsson, Alexandra Stubelius, Louise Grahnemo, Claes Ohlsson, Hans Carlsten, Ulrika Islander
Endocrinology - 2016 -
Enzalutamide Reduces the Bone Mass in the Axial but not the Appendicular Skeleton in Male
Mice.
Jianyao Wu, Sofia Movérare-Skrtic, Anna E Börjesson, Marie K Lagerquist, Klara Sjögren, Sara H Windahl, Antti Koskela, Louise Grahnemo, Ulrika Islander, Anna S K Wilhelmson, Åsa Tivesten, Juha Tuukkanen, Claes Ohlsson
Endocrinology - 2016 -
Dietary polyunsaturated fatty acids increase survival and decrease bacterial load during septic S. aureus infection, and improve neutrophil function in
mice
Sara L Svahn, Louise Grahnemo, Vilborg Palsdottir, Intawat Nookaew, Karl Wendt, Britt G. Gabrielsson, Erik Scheele, Anna Benrick, Niklas Andersson, Staffan Nilsson, Maria E Johansson, John-Olov Jansson
Infection and Immunity - 2015 -
IL-17-producing γδT cells are regulated by estrogen during development of experimental
arthritis.
Annica Andersson, Louise Grahnemo, Cecilia Engdahl, Alexandra Stubelius, Marie K Lagerquist, Hans Carlsten, Ulrika Islander
Clinical immunology (Orlando, Fla.) - 2015 -
Trabecular bone loss in collagen antibody-induced
arthritis
Louise Grahnemo, Annica Andersson, Merja Nurkkala Karlsson, Alexandra Stubelius, Marie K Lagerquist, Mattias Svensson, Claes Ohlsson, Hans Carlsten, Ulrika Islander
Arthritis Research & Therapy - 2015 -
Selective estrogen receptor modulators in T cell development and T cell dependent
inflammation
Angelina I Bernardi, Annica Andersson, Alexandra Stubelius, Louise Grahnemo, Hans Carlsten, Ulrika Islander
Immunobiology - 2015 -
Estrogen regulates T helper 17 phenotype and localization in experimental autoimmune
arthritis
Annica Andersson, Alexandra Stubelius, Merja Nurkkala Karlsson, Cecilia Engdahl, Malin Erlandsson, Louise Grahnemo, Marie K Lagerquist, Ulrika Islander
Arthritis Research & Therapy - 2015 -
Possible role of lymphocytes in glucocorticoid-induced increase in trabecular bone mineral
density.
Louise Grahnemo, Caroline Jochems, Annica Andersson, Cecilia Engdahl, Claes Ohlsson, Ulrika Islander, Hans Carlsten
The Journal of endocrinology - 2015 -
Effects of lasofoxifene and bazedoxifene on B cell development and
function.
Angelina I Bernardi, Annica Andersson, Louise Grahnemo, Merja Nurkkala Karlsson, Claes Ohlsson, Hans Carlsten, Ulrika Islander
Immunity, inflammation and disease - 2014 -
Glucose impairs B-1 cell function in
diabetes.
Karin Jennbacken, Sara Ståhlman, Louise Grahnemo, Olov Wiklund, Linda Fogelstrand
Clinical and experimental immunology - 2013 -
The gut microbiota reduces leptin sensitivity and the expression of the obesity-suppressing neuropeptides proglucagon (Gcg) and brain-derived neurotrophic factor (Bdnf) in the central nervous
system.
Erik Schéle, Louise Grahnemo, Fredrik Anesten, Anna Hallén, Fredrik Bäckhed, John-Olov Jansson
Endocrinology - 2013 -
Interrelation between interleukin-1 (IL-1), IL-6 and body fat regulating circuits of the hypothalamic arcuate
nucleus.
Erik Schéle, Anna Benrick, Louise Grahnemo, Emil Egecioglu, Fredrik Anesten, Vilborg Palsdottir, John-Olov Jansson
Journal of neuroendocrinology - 2013 -
A variant near the interleukin-6 gene is associated with fat mass in Caucasian
men
Niklas Andersson, Louise Strandberg, Staffan Nilsson, Svetlana Adamovic, M. K. Karlsson, O. Ljunggren, Dan Mellström, N. E. Lane, J. M. Zmuda, C. Nielsen, E. Orwoll, Mattias Lorentzon, Claes Ohlsson, John-Olov Jansson
International Journal of Obesity - 2010 -
Variants of the interleukin-1 receptor antagonist gene are associated with fat mass in
men.
Niklas Andersson, Louise Strandberg, Staffan Nilsson, Ö Ljungren, Magnus K Karlsson, Dan Mellström, Mattias Lorentzon, Claes Ohlsson, John-Olov Jansson
International journal of obesity (2005) - 2009 -
Mice chronically fed high-fat diet have increased mortality and disturbed immune response in
sepsis.
Louise Strandberg, Margareta Verdrengh, Maria Enge, Niklas Andersson, Sylvie Amu, Karin Önnheim, Anna Benrick, Mikael Brisslert, Johan Bylund, Maria Bokarewa, Staffan Nilsson, John-Olov Jansson
PloS one - 2009 -
Interactions between nutrition, obesity and the immune
system
Louise Strandberg
2009 -
IL6 and IL1B polymorphisms are associated with fat mass in older men: the MrOS Study
Sweden.
Louise Strandberg, Dan Mellström, Osten Ljunggren, Elin Grundberg, Magnus K Karlsson, Anna H Holmberg, Eric S Orwoll, Anna-Lena Eriksson, Johan Svedberg, Magnus Bengtsson, Claes Ohlsson, John-Olov Jansson
Obesity (Silver Spring, Md.) - 2008 -
Interleukin-1 system gene polymorphisms are associated with fat mass in young
men.
Louise Strandberg, Mattias Lorentzon, Åsa Hellqvist, Staffan Nilsson, Ville Wallenius, Claes Ohlsson, John-Olov Jansson
The Journal of clinical endocrinology and metabolism - 2006