Cecilia Engdahl
Researcher
Department of Rheumatology a InflammationAbout Cecilia Engdahl
In 2017, Cecilia rejoins CBAR (Centre for Bone and Arthritis Research), after a Post Doc with Georg Schett in Erlangen, Germany. In Schetts lab she started to investigate the impact of autoantibodies for the induction of rheumatoid arthritis as well as for bone loss. This work will continue in her independent group at CBAR were she will investigate posttranslational modification of antibodies and their impact on immune cell and osteoclast activation. Cecilias project are funded from International Postdoc from Swedish Research Council and from Swedish Society for Medical Research.
PhD students: Karin Gustafsson (2014-) (Co-superviser)
PostDoc: Jasmin Raufer (2016-2017), Medizin III, UK Erlangen, FAU Erlangen-Nürnberg
Main Research Topic
Antibodies are constantly produced from plasma cells and are part of our memory system towards antigens. Antibodies against own antigen, autoantibodies, are important in the induction step of rheumatoid arthritis (RA) and could be detected already in the preclinical phase of disease. Antibodies affect the immune cells, including osteoclast, via the Fcγreceptors and their binding capacity are altered of sugar structures attached to the antibodies. Cecilia will investigate this sugar structures, in different aspect. If estrogen affects them, which could partly explain why menopause both give rise to a higher peak incidence of RA as well as bone loss. Further will the periarticular bone loss be investigated, bone loss in close but not direct connection to the arthritis. Here will the sugar structure of the antibodies be investigated together with other aspect influencing both arthritis as well as the local bone loss.
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Immunoglobulin G complexes without sialic acids enhance osteoclastogenesis but do not affect arthritis-mediated bone
loss.
Edina Sehic, Anna Westerlund, Marie K Lagerquist, Ulf H Lerner, Hans Carlsten, Petra Henning, Cecilia Engdahl
Scandinavian journal of immunology - 2020-01-01 -
Arginine site 264 in murine estrogen receptor alpha is dispensable for the regulation of the
skeleton.
Karin L. Gustafsson, Helen H. Farman, Karin H. Nilsson, Petra Henning, Sofia Movérare-Skrtic, Vikte Lionikaite, Lina Lawenius, Cecilia Engdahl, Claes Ohlsson, Marie K Lagerquist
American journal of physiology. Endocrinology and metabolism - 2020-01-01 -
Interleukin 17A: a Janus-faced regulator of
osteoporosis
Julia M. Scheffler, Louise Grahnemo, Cecilia Engdahl, Christina Drevinge, Karin L. Gustafsson, Carmen Corciulo, Lina Lawenius, Y. Iwakura, Klara Sjögren, Marie Lagerquist, Hans Carlsten, Claes Ohlsson, Ulrika Islander
Scientific Reports - 2020-01-01 -
Tofacitinib treatment aggravates Staphylococcus aureus septic arthritis, but attenuates sepsis and enterotoxin induced shock in
mice
Anders Jarneborn, Majd Mohammad, Cecilia Engdahl, Zhicheng Hu, Manli Na, Abukar Ali, Tao Jin
Scientific Reports - 2020-01-01 -
Changes in mechanical loading affect arthritis-induced bone loss in
mice.
Anna-Maria Liphardt, Sara H Windahl, Edina Sehic, Nicole Hannemann, Karin L. Gustafsson, Aline Bozec, Georg Schett, Cecilia Engdahl
Bone - 2020-01-01 -
The YIN and YANG of lipoproteins in developing and preventing infectious arthritis by Staphylococcus
aureus.
Majd Mohammad, Minh-Thu Nguyen, Cecilia Engdahl, Manli Na, Anders Jarneborn, Zhicheng Hu, Anna Karlsson, Rille Pullerits, Abukar Ali, Friedrich Götz, Tao Jin
PLoS pathogens - 2019-01-01 -
Roles of activating functions 1 and 2 of estrogen receptor α in
lymphopoiesis.
Annica Andersson, Sofia Movérare-Skrtic, Angelina I Bernardi, Helen H. Farman, Pierre Chambon, Cecilia Engdahl, Marie Lagerquist, Sara H Windahl, Hans Carlsten, Claes Ohlsson, Ulrika Islander
The Journal of endocrinology - 2018-01-01 -
Estrogen induces St6gal1 expression and increases IgG sialylation in mice and patients with rheumatoid arthritis: A potential explanation for the increased risk of rheumatoid arthritis in postmenopausal
women
Cecilia Engdahl, A. Bondt, U. Harre, J. Raufer, R. Pfeifle, Alessandro Camponeschi, M. Wuhrer, M. Seeling, Inga-Lill Mårtensson, F. Nimmerjahn, G. Krönke, H. U. Scherer, Helena Forsblad d'Elia, G. Schett
Arthritis Research and Therapy - 2018-01-01 -
SERMs have substance-specific effects on bone, and these effects are mediated via ER alpha AF-1 in female
mice
Anna E Börjesson, Helen H. Farman, Sofia Movérare-Skrtic, Cecilia Engdahl, M. C. Antal, A. Koskela, J. Tuukkanen, Hans Carlsten, A. Krust, P. Chambon, Klara Sjögren, Marie K Lagerquist, Sara H Windahl, Claes Ohlsson
American Journal of Physiology-Endocrinology and Metabolism - 2016-01-01 -
IL-17-producing γδT cells are regulated by estrogen during development of experimental
arthritis.
Annica Andersson, Louise Grahnemo, Cecilia Engdahl, Alexandra Stubelius, Marie K Lagerquist, Hans Carlsten, Ulrika Islander
Clinical immunology (Orlando, Fla.) - 2015-01-01 -
Estrogen regulates T helper 17 phenotype and localization in experimental autoimmune
arthritis
Annica Andersson, Alexandra Stubelius, Merja Nurkkala Karlsson, Cecilia Engdahl, Malin Erlandsson, Louise Grahnemo, Marie K Lagerquist, Ulrika Islander
Arthritis Research & Therapy - 2015-01-01 -
Possible role of lymphocytes in glucocorticoid-induced increase in trabecular bone mineral
density.
Louise Grahnemo, Caroline Jochems, Annica Andersson, Cecilia Engdahl, Claes Ohlsson, Ulrika Islander, Hans Carlsten
The Journal of endocrinology - 2015-01-01 -
Osteoblast-derived WNT16 represses osteoclastogenesis and prevents cortical bone fragility
fractures.
Sofia Movérare-Skrtic, Petra Henning, Xianwen Liu, Kenichi Nagano, Hiroaki Saito, Anna E Börjesson, Klara Sjögren, Sara H Windahl, Helen H. Farman, Bert Kindlund, Cecilia Engdahl, Antti Koskela, Fu-Ping Zhang, Emma E Eriksson, Farasat Zaman, Ann Hammarstedt, Hanna Isaksson, Marta Bally, Ali Kassem, Catharina Lindholm, Olof Sandberg, Per Aspenberg, Lars Sävendahl, Jian Q Feng, Jan Tuckermann, Juha Tuukkanen, Matti Poutanen, Roland Baron, Ulf H Lerner, Francesca Gori, Claes Ohlsson
Nature Medicine - 2014-01-01 -
The effect of estrogen on bone requires ER alpha in nonhematopoietic cells but is enhanced by ER alpha in hematopoietic
cells
Petra Henning, Claes Ohlsson, Cecilia Engdahl, Helen H. Farman, Sara H Windahl, Hans Carlsten, Marie K Lagerquist
American Journal of Physiology-Endocrinology and Metabolism - 2014-01-01 -
The role of total and cartilage-specific estrogen receptor alpha expression for the ameliorating effect of estrogen treatment on
arthritis.
Cecilia Engdahl, Anna E Börjesson, Huamei Forsman, Annica Andersson, Alexandra Stubelius, Andree Krust, Pierre Chambon, Ulrika Islander, Claes Ohlsson, Hans Carlsten, Marie K Lagerquist
Arthritis research & therapy - 2014-01-01 -
Probiotics protect mice from ovariectomy-induced cortical bone
loss.
Claes Ohlsson, Cecilia Engdahl, Frida Fåk, Annica Andersson, Sara H Windahl, Helen H. Farman, Sofia Movérare-Skrtic, Ulrika Islander, Klara Sjögren
PloS one - 2014-01-01 -
Role of Androgen and Estrogen Receptors for the Action of Dehydroepiandrosterone
(DHEA)
Cecilia Engdahl, Marie K Lagerquist, Alexandra Stubelius, Annica Andersson, Erik Studer, Claes Ohlsson, Lars Westberg, Hans Carlsten, Helena Forsblad d'Elia
Endocrinology - 2014-01-01 -
The role of activation functions 1 and 2 of estrogen receptor-alpha for the effects of estradiol and selective estrogen receptor modulators in male
mice
Anna E Börjesson, Helen H. Farman, Cecilia Engdahl, A. Koskela, Klara Sjögren, Jenny Kindblom, Alexandra Stubelius, Ulrika Islander, Hans Carlsten, M. C. Antal, A. Krust, P. Chambon, J. Tuukkanen, Marie K Lagerquist, Sara H Windahl, Claes Ohlsson
Journal of Bone and Mineral Research - 2013-01-01 -
Periarticular bone loss in antigen-induced
arthritis.
Cecilia Engdahl, Catharina Lindholm, Alexandra Stubelius, Claes Ohlsson, Hans Carlsten, Marie Lagerquist
Arthritis and rheumatism - 2013-01-01 -
Estrogen receptor-alpha in osteocytes is important for trabecular bone formation in male
mice
Sara H Windahl, Anna E Börjesson, Helen H. Farman, Cecilia Engdahl, Sofia Movérare-Skrtic, Klara Sjögren, Marie Lagerquist, Jenny Kindblom, A. Koskela, J. Tuukkanen, P. D. Pajevic, J. Q. Feng, K. Dahlman-Wright, P. Antonson, J. A. Gustafsson, Claes Ohlsson
Proceedings of the National Academy of Sciences of the United States of America - 2013-01-01 -
Estrogen receptor-α is required for the osteogenic response to mechanical loading in a ligand-independent manner involving its activation function 1 but not
2.
Sara H Windahl, L Saxon, Anna E Börjesson, Marie Lagerquist, B Frenkel, Petra Henning, Ulf H Lerner, Gl Galea, Lb Meakin, Cecilia Engdahl, Klara Sjögren, Mc Antal, A Krust, P Chambon, LE Lanyon, Js Price, Claes Ohlsson
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research - 2013-01-01 -
Exosomal secretion of death bullets: a new way of apoptotic
escape?
N. Trokovic, R. Pollanen, P. Porola, V. Stegaev, U. Hetzel, Åsa Tivesten, Cecilia Engdahl, Hans Carlsten, Helena Forsblad d'Elia, Johan Bourghardt Fagman, Marie Lagerquist, Y. T. Konttinen
American Journal of Physiology-Endocrinology and Metabolism - 2012-01-01 -
Arthritis and immune-mediated bone loss - role of estrogen signalling
pathways
Cecilia Engdahl
- 2012-01-01 -
The role of estrogen receptor-alpha and its activation function-1 for growth plate closure in female
mice
Anna E Börjesson, Sara H Windahl, E. Karimian, E. E. Eriksson, Marie Lagerquist, Cecilia Engdahl, M. C. Antal, A. Krust, P. Chambon, L. Savendahl, Claes Ohlsson
American Journal of Physiology-Endocrinology and Metabolism - 2012-01-01 -
The gut microbiota regulates bone mass in
mice
Klara Sjögren, Cecilia Engdahl, Petra Henning, Ulf H Lerner, Valentina Tremaroli, Marie Lagerquist, Fredrik Bäckhed, Claes Ohlsson
Journal of Bone and Mineral Research - 2012-01-01 -
Estrogen receptor-α expression in neuronal cells affects bone
mass.
Claes Ohlsson, Cecilia Engdahl, Anna E Börjesson, Sara H Windahl, Erik Studer, Lars Westberg, Elias Eriksson, Antti Koskela, Juha Tuukkanen, Andree Krust, Pierre Chambon, Hans Carlsten, Marie Lagerquist
Proceedings of the National Academy of Sciences of the United States of America - 2012-01-01 -
Effects of oestradiol and raloxifene on the induction and effector phases of experimental postmenopausal arthritis and secondary
osteoporosis
Caroline Jochems, Ulrika Islander, Malin Erlandsson, Cecilia Engdahl, Marie Lagerquist, Claes Ohlsson, Kutty Selva Nandakumar, Rikard Holmdahl, Hans Carlsten
Clinical and Experimental Immunology - 2011-01-01 -
Roles of transactivating functions 1 and 2 of estrogen receptor-alpha in
bone.
Anna E Börjesson, Sara H Windahl, Marie Lagerquist, Cecilia Engdahl, B Frenkel, Sofia Movérare-Skrtic, Klara Sjögren, Jenny Kindblom, Alexandra Stubelius, Ulrika Islander, Mc Antal, A Krust, P Chambon, Claes Ohlsson
Proceedings of the National Academy of Sciences of the United States of America - 2011-01-01 -
Role of endogenous and exogenous female sex hormones in arthritis and osteoporosis development in B10.Q-ncf1*/* mice with collagen-induced chronic
arthritis.
Caroline Jochems, Ulrika Islander, Malin Erlandsson, Cecilia Engdahl, Marie Lagerquist, Inger Gjertsson, Claes Ohlsson, Rikard Holmdahl, Hans Carlsten
BMC musculoskeletal disorders - 2010-01-01 -
Amelioration of collagen-induced arthritis and immune-associated bone loss through signaling via estrogen receptor alpha, and not estrogen receptor beta or G protein-coupled receptor
30.
Cecilia Engdahl, Caroline Jochems, Sara H Windahl, Anna E Börjesson, Claes Ohlsson, Hans Carlsten, Marie Lagerquist
Arthritis and rheumatism - 2010-01-01 -
In Vivo activation of gene transcription via estrogen response elements by raloxifene
analogue.
Cecilia Engdahl, Caroline Jochems, Gustafsson, van der Saag, Hans Carlsten, Marie Lagerquist
The Journal of endocrinology - 2009-01-01