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Cecilia Engdahl

Researcher

Department of Rheumatology a Inflammation
Research
Visiting address
Guldhedsgatan 10A
41390 Göteborg
Postal address
Box 480
40530 Göteborg

About Cecilia Engdahl

In 2017, Cecilia rejoins CBAR (Centre for Bone and Arthritis Research), after a Post Doc with Georg Schett in Erlangen, Germany. In Schetts lab she started to investigate the impact of autoantibodies for the induction of rheumatoid arthritis as well as for bone loss. This work will continue in her independent group at CBAR were she will investigate posttranslational modification of antibodies and their impact on immune cell and osteoclast activation. Cecilias project are funded from International Postdoc from Swedish Research Council and from Swedish Society for Medical Research.

PhD students: Karin Gustafsson (2014-) (Co-superviser)

PostDoc: Jasmin Raufer (2016-2017), Medizin III, UK Erlangen, FAU Erlangen-Nürnberg

Main Research Topic

Antibodies are constantly produced from plasma cells and are part of our memory system towards antigens. Antibodies against own antigen, autoantibodies, are important in the induction step of rheumatoid arthritis (RA) and could be detected already in the preclinical phase of disease. Antibodies affect the immune cells, including osteoclast, via the Fcγreceptors and their binding capacity are altered of sugar structures attached to the antibodies. Cecilia will investigate this sugar structures, in different aspect. If estrogen affects them, which could partly explain why menopause both give rise to a higher peak incidence of RA as well as bone loss. Further will the periarticular bone loss be investigated, bone loss in close but not direct connection to the arthritis. Here will the sugar structure of the antibodies be investigated together with other aspect influencing both arthritis as well as the local bone loss.