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- Ulf Smith
Ulf Smith
Senior Researcher
Department of Molecular and Clinical MedicineAbout Ulf Smith
Professor, Principal Investigator, MD, PhD, FRCP
Ulf Smith is Professor of Internal Medicine and Director of the Lundberg Laboratory for Diabetes Research at the Sahlgrenska Academy, University of Gothenburg, Sweden. He has held many administrative positions including Chair of the Institute of Medicine, Chief-of-Medicine and Executive Medical Director of the Sahlgrenska University Hospital. He has been member of the Scientific Board of the Sahlgrenska Academy and Dean of Research of the Academy.
Professor Smith is a diabetologist and his research is focused on the pathogenesis of Type 2 diabetes and its complications. He has published around 500 scientific papers in the field and received many honors for his work including being a Fogarty Scholar at the NIH, Bethesda, USA.
Professor Smith is Past President of the European Association for the Study of Diabetes and Chair of the European Foundation for the Study of Diabetes. He is also Past President of the Alliance for Biomedical Research in Europe. He is chairman/member of several Scientific Advisory Boards. He has currently a position as member of the European Commission Scientific Panel for Health at the European Commission.
For information of group members and their work, please visit the website for the Lundberg Laboratory for Diabetes Research.
Main research
For information of group members and their work, please visit the website for the Lundberg Laboratory for Diabetes Research.
Group members
For information of group members and their work, please visit the website for the Lundberg Laboratory for Diabetes Research. Group members
Key Publications
- Grünberg JR, Hoffmann JM, Hedjazifar S, Nerstedt A, Jenndahl L, Elvin J, Castellot J, Wei L, Movérare-Skrtic S, Ohlsson C, Mannerås Holm L, Bäckhed F, Syed I, Bosch F, Saghatelian A, Kahn BB, Hammarstedt A and Smith U. Overexpressing the novel autocrine/endocrine adipokine WISP2 induces hyperplasia of the heart, white and brown adipose tissues and prevents insulin resistance. Sci Rep. DOI: 10.1038/srep43515, (2017)
- Lee S, Zhang C, Kilicarslan M, Piening BD, Bjornson E, Hallström BM, Groen AK, Ferrannini E, Laakso M, Snyder M, Blüher M, Uhlen M, Nielsen J, Smith U, Serlie M, Borén J and Mardinoglu A. Integrated network analysis reveals an association between plasma mannose levels and insulin resistance. Cell Metab. 24:172-184. (2016)
- Smith U. Abdominal obesity – a marker of ectopic fat accumulation. J Clin Invest. 125(5):1790-1792. (2015)
- Gustafson B, Hammarstedt A, Hedjazifar S, Hoffman JM, Svensson P-A, Grimsby J, Rondinone C and Smith U. BMP4 and BMP antagonists regulate human white and beige adipogenesis. Diabetes. 64:1670-1681. (2015)
- Yore MM, Syed IS, Moraes-Vieira PM, Zhang T, Herman MA, Homan E.A, Patel R.T, Lee J, Chen S, Peroni O.D, Dhaneshwar AS, Hammarstedt A, Smith U, McGraw TE, Saghatelian A and Kahn BB. Discovery of a Class of Endogenous Mammalian Lipids with Anti-Diabetic and Anti-inflammatory Effects. Cell. 159(2):318-332. (2014)
- Hammarstedt A, Hedjazifar S, Jenndahl L, Gogg S, Grünberg J, Gustafson B, Klimcakova E, Stich V, Langin D, Laakso M and Smith U. WISP2 Regulates Preadipocyte Commitment and PPAR gamma Activation by BMP4. Proc Natl Acad Sci USA. 110:2563-2568. (2013)
- Isakson P, Hammarstedt A, Gustafson B and Smith U. Impaired preadipocytes differentiation in human abdominal obesity – role of Wnt, TNFalpha and inflammation. Diabetes. 58:1550-1557. (2009)
- Eliasson B, Taskinen M-R and Smith U. Long-term use of nicotine gum is associated with hyperinsulinemia and insulin resistance. Circulation. 94:878-881. (1996)
- Graham TE, Yang Q, Bluher M, Hammarstedt A, Ciaraldi TP, Henry RR, Wason CJ, Oberbach A, Jansson P-A, Smith U and Kahn BB. Retinol binding protein 4 and insulin resistance in lean, obese, and diabetic subjects. N Engl J Med. 354:2552-2563. (2006)
- Rondinone CM, Wang L-M, Lönnroth P, Wesslau C, Pierce JH and Smith U. Insulin receptor substrate (IRS) 1 is reduced and IRS-2 is the main docking protein for phosphatidylinositol 3-kinase in adipocytes from subjects with non-insulin-dependent diabetes mellitus. Proc Natl Acad Sci USA. 94:4171-4175. (1997)
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Physical training reduces cell senescence and associated insulin resistance in skeletal
muscle
Agnieszka Podraza-Farhanieh, Rosa Spinelli, Federica Zatterale, Annika Nerstedt, Silvia Gogg, Matthias Blueher, Ulf Smith
MOLECULAR METABOLISM - 2025 -
Breast volume in non-obese females is related to breast adipose cell hypertrophy, inflammation, and COX2
expression.
Silvia Gogg, Annika Nerstedt, Ulf Smith, Emma Hansson
Journal of Plastic Surgery and Hand Surgery - 2024 -
The impact of cellular senescence in human adipose
tissue
Annika Nerstedt, Ulf Smith
Journal of Cell Communication and Signaling - 2023 -
Altered H3K4me3 profile at the TFAM promoter causes mitochondrial alterations in preadipocytes from first-degree relatives of type 2
diabetics
Michele Longo, Federica Zatterale, Rosa Spinelli, Jamal Naderi, Luca Parrillo, Pasqualina Florese, Cecilia Nigro, Alessia Leone, Augusta Moccia, Antonella Desiderio, Gregory A. Raciti, Claudia Miele, Ulf Smith, Francesco Beguinot
CLINICAL EPIGENETICS - 2023 -
Report on the 11th international workshop on the CCN family of genes, Nice, October 20-24,
2022
Havard Attramadal, Sushanta K. Banerjee, Brahim Chaqour, Gary Fisher, Lester Lau, Bernard Perbal, Ulf Smith, Herman Yeger
JOURNAL OF CELL COMMUNICATION AND SIGNALING - 2023 -
Cardiac arrhythmias and conduction abnormalities in patients with type 2
diabetes
Araz Rawshani, D. K. McGuire, Elmir Omerovic, N. Sattar, J. J. V. McMurray, Ulf Smith, Björn Redfors, Lennart Bergfeldt, Björn Eliasson, Jan Borén, D. L. Bhatt, Göran Bergström, Aidin Rawshani
Scientific Reports - 2023 -
Increased cell senescence in human metabolic
disorders
Rosa Spinelli, Ritesh Baboota, Silvia Gogg, F. Beguinot, M. Bluher, Annika Nerstedt, Ulf Smith
Journal of Clinical Investigation - 2023 -
BMP4 and Gremlin 1 regulate hepatic cell senescence during clinical progression of
NAFLD/NASH
Ritesh Baboota, Aidin Rawshani, Laurianne Bonnet, X. Y. Li, H. Yang, A. Mardinoglu, T. Tchkonia, J. L. Kirkland, A. Hoffmann, A. Dietrich, Jeremie Boucher, M. Bluher, Ulf Smith
Nature Metabolism - 2022 -
Left-Sided Degenerative Valvular Heart Disease in Type 1 and Type 2
Diabetes
Araz Rawshani, N. Sattar, D. K. McGuire, Oskar Wallström, Ulf Smith, Jan Borén, Göran Bergström, Elmir Omerovic, Annika Rosengren, Björn Eliasson, D. L. Bhatt, Aidin Rawshani
Circulation - 2022 -
Chronic hyperinsulinemia promotes human hepatocyte
senescence.
Ritesh Baboota, Rosa Spinelli, Malin Erlandsson, Bruna B Brandao, Marsel Lino, Hong Yang, Adil Mardinoglu, Maria Bokarewa, Jeremie Boucher, C Ronald Kahn, Ulf Smith
Molecular metabolism - 2022 -
Epigenetic Dysregulation of the Homeobox A5 (HOXA5) Gene Associates with Subcutaneous Adipocyte Hypertrophy in Human
Obesity
L. Parrillo, R. Spinelli, M. Costanzo, P. Florese, S. Cabaro, A. Desiderio, I. Prevenzano, G. A. Raciti, Ulf Smith, C. Miele, P. Formisano, R. Napoli, F. Beguinot
Cells - 2022 -
ZMAT3 hypomethylation contributes to early senescence of preadipocytes from healthy first-degree relatives of type 2
diabetics
R. Spinelli, P. Florese, L. Parrillo, F. Zatterale, M. Longo, V. D'Esposito, A. Desiderio, Annika Nerstedt, Birgit Gustafson, P. Formisano, C. Miele, G. A. Raciti, R. Napoli, Ulf Smith, F. Beguinot
Aging Cell - 2022 -
Cellular senescence in hepatocytes contributes to metabolic disturbances in
NASH
Laurianne Bonnet, Ida Alexandersson, Ritesh Baboota, Tobias Kroon, J. Oscarsson, Ulf Smith, Jeremie Boucher
Frontiers in Endocrinology - 2022 -
Type 2 Diabetes, Independent of Obesity and Age, Is Characterized by Senescent and Dysfunctional Mature Human Adipose
Cells
Birgit Gustafson, Annika Nerstedt, R. Spinelli, F. Beguinot, Ulf Smith
Diabetes - 2022 -
Metabolite Signature of Albuminuria Involves Amino Acid Pathways in 8661 Finnish Men Without
Diabetes
L. F. Silva, J. Vangipurapu, Ulf Smith, M. Laakso
Journal of Clinical Endocrinology & Metabolism - 2021 -
Adipocyte precursor cells from first degree relatives of type 2 diabetic patients feature changes in hsa-mir-23a-5p, -193a-5p, and -193b-5p and insulin-like growth factor 2
expression
P. Mirra, A. Desiderio, R. Spinelli, C. Nigro, M. Longo, L. Parrillo, V. D'Esposito, A. Carissimo, Shahram Hedjazifar, Ulf Smith, P. Formisano, C. Miele, G. A. Raciti, F. Beguinot
FASEB Journal - 2021 -
Emerging Role of Bone Morphogenetic Protein 4 in Metabolic
Disorders
Ritesh Baboota, M. Bluher, Ulf Smith
Diabetes - 2021 -
Identification of markers that distinguish adipose tissue and glucose and insulin metabolism using a multi-modal machine learning
approach
Josefin Henninger, Björn Eliasson, Ulf Smith, Aidin Rawshani
Scientific Reports - 2021 -
Cellular senescence and its role in white adipose
tissue
Ulf Smith, Q. Li, M. Ryden, K. L. Spalding
International Journal of Obesity - 2021 -
Impact of the Uncoupling Protein 1 on Cardiovascular Risk in Patients with Rheumatoid
Arthritis
Lovisa Lyngfelt, Malin Erlandsson, Mitra Nadali, Shahram Hedjazifar, Rille Pullerits, Karin Andersson, Petra Brembeck, Sofia Töyrä Silfverswärd, Ulf Smith, Maria Bokarewa
Cells - 2021 -
Adult mice are unresponsive to AAV8-Gremlin1 gene therapy targeting the
liver
Roxana Khatib Shahidi, Jenny M Hoffmann, Shahram Hedjazifar, Laurianne Bonnet, Ritesh Baboota, S. Heasman, C. Church, I. Elias, F. Bosch, Jeremie Boucher, Ann Hammarstedt, Ulf Smith
PLoS ONE - 2021 -
Adipose tissue morphology, imaging and metabolomics predicting cardiometabolic risk and family history of type 2 diabetes in non-obese
men
Aidin Rawshani, Björn Eliasson, Araz Rawshani, Josefin Henninger, A. Mardinoglu, Åsa Carlsson, Maja Sohlin, Maria Ljungberg, Ann Hammarstedt, Annika Rosengren, Ulf Smith
Scientific Reports - 2020 -
Microbiota-Related Metabolites and the Risk of Type 2
Diabetes
J. Vangipurapu, L. F. Silva, T. Kuulasmaa, Ulf Smith, M. Laakso
Diabetes care - 2020 -
Altered PTPRD DNA methylation associates with restricted adipogenesis in healthy first-degree relatives of Type 2 diabetes
subjects
L. Parrillo, R. Spinelli, M. Longo, A. Desiderio, P. Mirra, C. Nigro, F. Fiory, Shahram Hedjazifar, M. Mutarelli, A. Carissimo, P. Formisano, C. Miele, Ulf Smith, G. A. Raciti, F. Beguinot
Epigenomics - 2020 -
BMP4 gene therapy enhances insulin sensitivity but not adipose tissue browning in obese
mice
Jenny M Hoffmann, John Grünberg, Ann Hammarstedt, T. Kroon, Thomas U. Greiner, S. Maurer, I. Elias, Vilborg Palsdottir, F. Bosch, Jeremie Boucher, Shahram Hedjazifar, Ulf Smith
Molecular Metabolism - 2020 -
The European medical information framework: A novel ecosystem for sharing healthcare data across
Europe
S. Lovestone, B. Vannieuwenhuyse, P. J. Visser, I. Bos, S. Vos, J. Streffer, Ulf Smith, D. Waterworth, J. van der Lei, P. Rijnbeek, J. L. Oliveira, M. Van Speybroeck, R. Verbeeck, D. Kalra, N. Lea, E. Molero, M. Lewi, M. Alexander, G. James, C. Sage, J. Praet, P. Egger, G. Singh, N. Hughes
Learning Health Systems - 2020 -
Mannose is an insulin-regulated metabolite reflecting whole-body insulin sensitivity in
man
E. Ferrannini, Maria Bokarewa, Petra Brembeck, Ritesh Baboota, Shahram Hedjazifar, S. Baldi, B. Campi, E. Muscelli, A. Saba, I. Sterner, Caroline Wasén, Ulf Smith
Metabolism: Clinical and Experimental - 2020 -
The Novel Adipokine Gremlin 1 Antagonizes Insulin Action and Is Increased in Type 2 Diabetes and
NAFLD/NASH
Shahram Hedjazifar, Roxana Khatib Shahidi, Ann Hammarstedt, Laurianne Bonnet, C. Church, Jeremie Boucher, M. Bluher, Ulf Smith
Diabetes - 2020 -
Cellular senescence: at the nexus between ageing and
diabetes
Allyson K. Palmer, Birgit Gustafson, James L. Kirkland, Ulf Smith
DIABETOLOGIA - 2019 -
Nine Amino Acids Are Associated With Decreased Insulin Secretion and Elevated Glucose Levels in a 7.4-Year Follow-up Study of 5,181 Finnish
Men
J. Vangipurapu, A. Stancakova, Ulf Smith, J. Kuusisto, M. Laakso
Diabetes - 2019 -
Human adipose tissue microvascular endothelial cells secrete PPARγ ligands and regulate adipose tissue lipid
uptake.
Silvia Gogg, Annika Nerstedt, Jan Borén, Ulf Smith
JCI insight - 2019 -
Reduced subcutaneous adipogenesis in human hypertrophic obesity is linked to senescent precursor
cells
Birgit Gustafson, Annika Nerstedt, Ulf Smith
Nature Communications - 2019 -
Integrative Personal Omics Profiles during Periods of Weight Gain and
Loss
B. D. Piening, W. Y. Zhou, K. Contrepois, H. Rost, G. J. G. Urban, T. Mishra, B. M. Hanson, E. J. Bautista, S. Leopold, C. Y. Yeh, D. Spakowicz, I. Banerjee, C. Chen, K. Kukurba, D. Perelman, C. Craig, E. Colbert, D. Salins, S. Rego, S. Lee, C. Zhang, J. Wheeler, M. R. Sailani, L. Liang, C. Abbott, M. Gerstein, A. Mardinoglu, Ulf Smith, D. L. Rubin, S. Pitteri, E. Sodergren, T. L. McLaughlin, G. M. Weinstock, M. P. Snyder
Cell Systems - 2018 -
Adipose tissue dysfunction is associated with low levels of the novel Palmitic Acid Hydroxystearic
Acids
Ann Hammarstedt, I. Syed, A. Vijayakumar, Björn Eliasson, Silvia Gogg, B. B. Kahn, Ulf Smith
Scientific Reports - 2018 -
Methodological Issues in Studying PAHSA Biology: Masking PAHSA
Effects.
Ismail Syed, Jennifer Lee, Odile D Peroni, Mark M Yore, Pedro M Moraes-Vieira, Anna Santoro, Kerry Wellenstein, Ulf Smith, Timothy E McGraw, Alan Saghatelian, Barbara B Kahn
Cell metabolism - 2018 -
Impaired Adipogenesis and Dysfunctional Adipose Tissue in Human Hypertrophic
Obesity
Ann Hammarstedt, Silvia Gogg, Shahram Hedjazifar, Annika Nerstedt, Ulf Smith
Physiological Reviews - 2018 -
Systems biology in hepatology: approaches and
applications
A. Mardinoglu, Jan Borén, Ulf Smith, M. Uhlen, J. Nielsen
Nature Reviews Gastroenterology & Hepatology - 2018 -
CCN5/WISP2 and metabolic
diseases
J. R. Grunberg, Johannes Elvin, A. Paul, Shahram Hedjazifar, Ann Hammarstedt, Ulf Smith
Journal of Cell Communication and Signaling - 2018 -
Elevated Plasma Levels of 3-Hydroxyisobutyric Acid Are Associated With Incident Type 2
Diabetes
A. Mardinoglu, Silvia Gogg, L. A. Lotta, A. Stancakova, Annika Nerstedt, Jan Borén, M. Bluher, E. Ferrannini, C. Langenberg, N. J. Wareham, M. Laakso, Ulf Smith
Ebiomedicine - 2018 -
Epigenetic modifications of the Zfp/ZNF423 gene control murine adipogenic commitment and are dysregulated in human hypertrophic
obesity.
Michele Longo, Gregory A Raciti, Federica Zatterale, Luca Parrillo, Antonella Desiderio, Rosa Spinelli, Ann Hammarstedt, Shahram Hedjazifar, Jenny M Hoffmann, Cecilia Nigro, Paola Mirra, Francesca Fiory, Pietro Formisano, Claudia Miele, Ulf Smith, Francesco Beguinot
Diabetologia - 2018 -
TP53INP2 regulates adiposity by activating β-catenin through autophagy-dependent sequestration of
GSK3β
M. Romero, A. Sabaté-Pérez, V. A. Francis, I. Castrillón-Rodriguez, Á Díaz-Ramos, M. Sánchez-Feutrie, X. Durán, M. Palacín, J. M. Moreno-Navarrete, Birgit Gustafson, Ann Hammarstedt, J. M. Fernández-Real, J. Vendrell, Ulf Smith, A. Zorzano
Nature Cell Biology - 2018 -
Increased adipose tissue aromatase activity improves insulin sensitivity and reduces adipose tissue inflammation in male
mice.
Claes Ohlsson, Ann Hammarstedt, Liesbeth Vandenput, Niina Saarinen, Henrik Ryberg, Sara H Windahl, Helen H. Farman, John-Olov Jansson, Sofia Movérare-Skrtic, Ulf Smith, Fu-Ping Zhang, Matti Poutanen, Shahram Hedjazifar, Klara Sjögren
American journal of physiology. Endocrinology and metabolism - 2017 -
Network analyses identify liver-specific targets for treating liver
diseases.
Sunjae Lee, Cheng Zhang, Zhengtao Liu, Martina Klevstig, Bani Mukhopadhyay, Mattias Bergentall, Resat Cinar, Marcus Ståhlman, Natasha Sikanic, Joshua K Park, Sumit Deshmukh, Azadeh M Harzandi, Tim Kuijpers, Morten Grøtli, Simon J Elsässer, Brian D Piening, Michael Snyder, Ulf Smith, Jens Nielsen, Fredrik Bäckhed, George Kunos, Mathias Uhlen, Jan Borén, Adil Mardinoglu
Molecular systems biology - 2017 -
BMP4 Gene Therapy in Mature Mice Reduces BAT Activation but Protects from Obesity by Browning Subcutaneous Adipose
Tissue.
Jenny M Hoffmann, John Grünberg, Christopher Church, Ivet Elias, Vilborg Palsdottir, John-Olov Jansson, Fatima Bosch, Ann Hammarstedt, Shahram Hedjazifar, Ulf Smith
Cell reports - 2017 -
Plasma Mannose Levels Are Associated with Incident Type 2 Diabetes and Cardiovascular
Disease.
Adil Mardinoglu, Alena Stančáková, Luca A Lotta, Johanna Kuusisto, Jan Borén, Matthias Blüher, Nicholas J Wareham, Ele Ferrannini, Per Henrik Groop, Markku Laakso, Claudia Langenberg, Ulf Smith
Cell metabolism - 2017 -
A Genome-Wide Association Study of IVGTT-Based Measures of First-Phase Insulin Secretion Refines the Underlying Physiology of Type 2 Diabetes
Variants
A. R. Wood, A. Jonsson, A. U. Jackson, N. Wang, N. van Leewen, N. D. Palmer, S. Kobes, J. Deelen, L. Boquete-Vilarino, J. Paananen, A. Stancakova, D. I. Boomsma, E. J. C. de Geus, E. M. W. Eekhoff, A. Fritsche, M. Kramer, G. Nijpels, A. Simonis-Bik, T. W. van Haeften, A. Mahajan, M. Boehnke, R. N. Bergman, J. Tuomilehto, F. S. Collins, K. L. Mohlke, K. Banasik, C. J. Groves, M. I. McCarthy, E. R. Pearson, A. Natali, A. Mari, T. A. Buchanan, K. D. Taylor, A. H. Xiang, A. P. Gjesing, N. Grarup, H. Eiberg, O. Pedersen, Y. D. Chen, M. Laakso, J. M. Norris, Ulf Smith, L. E. Wagenknecht, L. Baier, D. W. Bowden, T. Hansen, M. Walker, R. M. Watanabe, L. M. t Hart, R. L. Hanson, T. M. Frayling
Diabetes - 2017 -
Personal model-assisted identification of NAD(+) and glutathione metabolism as intervention target in
NAFLD
A. Mardinoglu, Elias Björnson, C. Zhang, Martina Klevstig, S. Soderlund, Marcus Ståhlman, Martin Adiels, A. Hakkarainen, N. Lundbom, M. Kilicarslan, B. M. Hallstrom, J. Lundbom, B. Verges, P. H. R. Barrett, G. F. Watts, M. J. Serlie, J. Nielsen, M. Uhlen, Ulf Smith, Hanns-Ulrich Marschall, M. R. Taskinen, Jan Borén
Molecular Systems Biology - 2017 -
Overexpressing the novel autocrine/endocrine adipokine WISP2 induces hyperplasia of the heart, white and brown adipose tissues and prevents insulin
resistance.
John Grünberg, Jenny M Hoffmann, Shahram Hedjazifar, Annika Nerstedt, Lachmi E Jenndahl, Johannes Elvin, John Castellot, Lan Wei, Sofia Movérare-Skrtic, Claes Ohlsson, Louise Mannerås Holm, Fredrik Bäckhed, Ismail Syed, Fatima Bosch, Alan Saghatelian, Barbara B Kahn, Ann Hammarstedt, Ulf Smith
Scientific reports - 2017 -
Cephalic phase of insulin secretion in response to a meal is unrelated to family history of type 2
diabetes
Björn Eliasson, Araz Rawshani, Mette Axelsen, Ann Hammarstedt, Ulf Smith
Plos One - 2017 -
The influence of insulin resistance on cerebrospinal fluid and plasma biomarkers of Alzheimer's
pathology.
Sarah Westwood, Benjamine Liu, Alison L Baird, Sneha Anand, Alejo J Nevado-Holgado, Danielle Newby, Maria Pikkarainen, Merja Hallikainen, Johanna Kuusisto, Johannes R Streffer, Gerald Novak, Kaj Blennow, Ulf Andreasson, Henrik Zetterberg, Ulf Smith, Markku Laakso, Hilkka Soininen, Simon Lovestone
Alzheimer's research & therapy - 2017
More publications
We have limited the number of publications on this page. Visit GUP (The Publication Database for Gothenburg University) to find more publications.