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Barbara Becattini
Researcher
Department of Molecular and Clinical Medicine-
Prevention of insulin-induced lipohypertrophy by coadministration of a low dose of high-affinity PI3K
inhibitors
Barbara Becattini, Andrea Usseglio Gaudi, Per-Anders Jansson, Giovanni Solinas
METABOLISM-CLINICAL AND EXPERIMENTAL - 2025 -
Ablation of PI3Ky in neurons protects mice from diet-induced obesity MASLD and insulin
resistance
Angela Molinaro, Arianna Mazzoli, Andrea Usseglio Gaudi, Amit Chand Gupta, Vagner Ramon Rodrigues Silva, Damien Ramel, Muriel Laffargue, Johan Ruud, Barbara Becattini, Giovanni Solinas
ISCIENCE - 2025 -
An adipoincretin effect links adipostasis with insulin
secretion.
Giovanni Solinas, Barbara Becattini
Trends in endocrinology and metabolism - 2024 -
Adipocyte PI3K links adipostasis with baseline insulin secretion at fasting through an adipoincretin
effect.
Barbara Becattini, Angela Molinaro, Marcus Henricsson, Jan Borén, Giovanni Solinas
Cell reports - 2024 -
Activation of GFRAL+ neurons induces hypothermia and glucoregulatory responses associated with nausea and
torpor.
Linda Engström-Ruud, Ferran Font Gironès, Joanna Zajdel, Lara Kern, Júlia Teixidor-Deulofeu, Louise Mannerås Holm, Alba Carreras, Barbara Becattini, Andreas Björefeldt, Eric Hanse, Henning Fenselau, Giovanni Solinas, Jens C Brüning, Thomas F Wunderlich, Fredrik Bäckhed, Johan Ruud
Cell reports - 2024 -
PI3K and AKT at the Interface of Signaling and
Metabolism.
Giovanni Solinas, Barbara Becattini
Current topics in microbiology and immunology - 2022 -
Somatic ablation of IKKβ in liver and leukocytes is not tolerated in obese mice but hepatic IKKβ deletion improves fatty liver and insulin
sensitivity.
Vagner Ramon Rodrigues Silva, Angela Molinaro, Andrea Usseglio Gaudi, Emanuel Fryk, Claudia Sardi, Maria Hammarlund, Filip Mjörnstedt, Maria E Johansson, Barbara Becattini, Per-Anders Jansson, Giovanni Solinas
FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 2022 -
PSD3 downregulation confers protection against fatty liver
disease.
Rosellina Margherita Mancina, Kavitha Sasidharan, Anna Lindblom, Ying Wei, Ester Ciociola, Oveis Jamialahmadi, Piero Pingitore, Anne-Christine Andréasson, Giovanni Pellegrini, Guido Baselli, Ville Männistö, Jussi Pihlajamäki, Vesa Kärjä, Stefania Grimaudo, Ilaria Marini, Marco Maggioni, Barbara Becattini, Federica Tavaglione, Carly Dix, Marie Castaldo, Stephanie Klein, Mark Perelis, Francois Pattou, Dorothée Thuillier, Violeta Raverdy, Paola Dongiovanni, Anna Ludovica Fracanzani, Felix Stickel, Jochen Hampe, Stephan Buch, Panu K Luukkonen, Daniele Prati, Hannele Yki-Järvinen, Salvatore Petta, Chao Xing, Clemens Schafmayer, Elmar Aigner, Christian Datz, Richard G Lee, Luca Valenti, Daniel Lindén, Stefano Romeo
Nature metabolism - 2022 -
JNK1 ablation improves pancreatic β-cell mass and function in db/db diabetic mice without affecting insulin sensitivity and adipose tissue
inflammation.
Arianna Mazzoli, Claudia Sardi, Ludovic Breasson, Franziska Theilig, Barbara Becattini, Giovanni Solinas
FASEB bioAdvances - 2021 -
Hyperinsulinemia and insulin resistance in the obese may develop as part of a homeostatic response to elevated free fatty acids: A mechanistic case-control and a population-based cohort
study
Emanuel Fryk, Josefin Olausson, Karin Mossberg, Lena Strindberg, M. Schmelz, Helén Brogren, L. M. Gan, S. Piazza, A. Provenzani, Barbara Becattini, L. Lind, Giovanni Solinas, Per-Anders Jansson
Ebiomedicine - 2021 -
PI3K gamma promotes obesity-associated hepatocellular carcinoma by regulating metabolism and
inflammation
Barbara Becattini, Ludovic Breasson, Claudia Sardi, F. Zani, Giovanni Solinas
Jhep Reports - 2021 -
Insulin signaling and glucose metabolism in different hepatoma cell lines deviate from hepatocyte physiology toward a convergent aberrant
phenotype
Angela Molinaro, Barbara Becattini, Giovanni Solinas
Scientific Reports - 2020 -
Insulin-Driven PI3K-AKT Signaling in the Hepatocyte Is Mediated by Redundant PI3Kα and PI3Kβ Activities and Is Promoted by
RAS.
Angela Molinaro, Barbara Becattini, Arianna Mazzoli, Augusto Bleve, Lucia Radici, Ingela Maxvall, Victoria Rotter Sopasakis, Antonio Molinaro, Fredrik Bäckhed, Giovanni Solinas
Cell Metabolism - 2019 -
PI3K gamma ablation does not promote diabetes in db/db mice, but improves insulin sensitivity and reduces pancreatic beta-cell
apoptosis
Ludovic Breasson, Claudia Sardi, Barbara Becattini, Fabio Zani, Giovanni Solinas
Faseb Journal - 2018 -
PI3Kγ activity in leukocytes promotes adipose tissue inflammation and early-onset insulin resistance during
obesity.
Ludovic Breasson, Barbara Becattini, Claudia Sardi, Angela Molinaro, Fabio Zani, Romina Marone, Fabrizio Botindari, Mélanie Bousquenaud, Curzio Ruegg, Matthias P Wymann, Giovanni Solinas
Science signaling - 2017 -
JNK at the crossroad of obesity, insulin resistance, and cell stress
response
Giovanni Solinas, Barbara Becattini
Molecular Metabolism - 2017 -
The role of PI3Kγ in metabolism and macrophage
activation.
Giovanni Solinas, Barbara Becattini
Oncotarget - 2017 -
JNK1 ablation in mice confers long-term metabolic protection from diet-induced obesity at the cost of moderate skin oxidative
damage.
Barbara Becattini, Fabio Zani, Ludovic Breasson, D'Agostino Vito, Claudia Sardi, Min-Kyung Choo, Alessandro Provenzani, Jin-Mo Park, Giovanni Solinas
The FASEB Journal - 2016 -
PER2 promotes glucose storage to hepatic glycogen during fasting and refeeding by inducing. Gys-2, PTG, and GL.
expression
Fabio Zani, Ludovic Breasson, Barbara Becattini, Jean-Pierre Montani, Alessandro Provenzani, Urs Albrecht, Juergen Ripperger, Giovanni Solinas
Molecular Metabolism - 2013 -
PI3Kγ within a Nonhematopoietic Cell Type Negatively Regulates Diet-Induced Thermogenesis and Promotes Obesity and Insulin
Resistance.
Barbara Becattini, Romina Marone, Fabio Zan, Denis Arsenijevic, Josiane Seydoux, Jean-Pierre Montan, Abdul G. Dulloo, Bernard Thorens, Frédéric Preitner, Matthias P. Wymann, Giovanni Solinas
Proceedings of the National Academy of Science of the United States of America - 2011 -
Identification of a new JNK inhibitor targeting the JNK-JIP interaction
site
John L. Stebbins, Surya K. De, Thomas Machleidt, Barbara Becattini, Jesus Vazquez, Christian Kuntzen, Li-Hsing Chen, Jason F. Cellitti, Megan Riel-Mehan, Aras Emdadi, Giovanni Solinas, Michael Karin, Maurizio Pellecchia
Proceedings of the National Academy of Science of the United States of America - 2008