Erik Larsson Lekholm
Professor
Department of Medical Biochemistry and Cell-
Non-coding driver mutations in human
cancer.
Kerryn Elliott, Erik Larsson
Nature reviews. Cancer - 2021-01-01 -
Characterization of cell-free breast cancer patient-derived scaffolds using liquid chromatography-mass spectrometry/mass spectrometry data and RNA sequencing
data
Göran Landberg, Emma Jonasson, Anna Gustafsson, Paul A. Fitzpatrick, Pauline Isakson, Joakim Karlsson, Erik Larsson, Andreas Svanström, Svanheidur Rafnsdottir, Emma Persson, Daniel Andersson, J. Rosendahl, S. Petronis, Parmida Ranji, Pernilla Gregersson, Ylva Magnusson, J. Hakansson, Anders Ståhlberg
Data in Brief - 2020-01-01 -
Accurate mapping of mitochondrial DNA deletions and duplications using deep
sequencing
Swaraj Basu, Xie Xie, Jay (Jennifer) Uhler, Carola Oldfors Hedberg, D. Milenkovic, O. R. Baris, S. Kimoloi, S. Matic, J. B. Stewart, N. G. Larsson, R. J. Wiesner, Anders Oldfors, Claes M Gustafsson, Maria Falkenberg, Erik Larsson
PLoS Genetics - 2020-01-01 -
Genomic profiling of the transcription factor Zfp148 and its impact on the p53
pathway
Zhiyuan V. Zou, Nadia Gul, Markus Lindberg, Abdulmalik Bokhari, Ella M. Eklund, Viktor Garellick, Angana A. H. Patel, Jozefina J. Dzanan, Ben Titmuss, Kristell Le Gal, Inger Johansson, Åsa Tivesten, Eva Forssell-Aronsson, Martin O. Bergö, Anna Staffas, Erik Larsson, Volkan I. Sayin, Per Lindahl
Scientific Reports - 2020-01-01 -
Systematic investigation of promoter substitutions resulting from somatic intrachromosomal structural alterations in diverse human
cancers
Babak Alaei-Mahabadi, Kerryn Elliott, Erik Larsson
Scientific Reports - 2020-01-01 -
Molecular profiling of driver events in metastatic uveal
melanoma
Joakim Karlsson, Lisa M Nilsson, Suman Mitra, Samuel Alsén, Ganesh V Shelke, Vasu R. Sah, Elin Forsberg, Ulrika Stierner, C. All-Eriksson, Berglind Osk Einarsdottir, Henrik Jespersen, Lars Ny, Per Lindnér, Erik Larsson, Roger Olofsson Bagge, Jonas A Nilsson
Nature Communications - 2020-01-01 -
Deep sequencing of mitochondrial DNA and characterization of a novel POLG mutation in a patient with
arPEO.
Carola Oldfors Hedberg, Bertil Macao, Swaraj Basu, Christopher Lindberg, Bradley Peter, Jay (Jennifer) Uhler, Erik Larsson, Maria Falkenberg, Anders Oldfors
Neurology. Genetics - 2020-01-01 -
Identification of breast cancer stem cell related genes using functional cellular assays combined with single-cell RNA sequencing in MDA-MB-231
cells
Emma Jonasson, Salim Ghannoum, Emma Persson, Joakim Karlsson, Thomas Kroneis, Erik Larsson, Göran Landberg, Anders Ståhlberg
Frontiers in Genetics - 2019-01-01 -
Lack of detectable neoantigen depletion signals in the untreated cancer
genome.
Jimmy Van den Eynden, Alejandro Jiménez-Sánchez, Martin L Miller, Erik Larsson
Nature genetics - 2019-01-01 -
Intragenomic variability and extended sequence patterns in the mutational signature of ultraviolet
light
Markus Lindberg, Martin Boström, Kerryn Elliott, Erik Larsson
Proceedings of the National Academy of Sciences of the United States of America - 2019-01-01 -
The MTH1 inhibitor TH588 is a microtubule-modulating agent that eliminates cancer cells by activating the mitotic surveillance
pathway
Nadia Gul, Joakim Karlsson, Carolina Tängemo, Sanna Linsefors, Samuel Tuyizere, Rosie Perkins, Chandu Ala, Zhiyuan V. Zou, Erik Larsson, M. O. Bergo, Per Lindahl
Scientific Reports - 2019-01-01 -
DNA polymerase η contributes to genome-wide lagging strand
synthesis.
Katrin Kreisel, Martin K M Engqvist, Josephine Kalm, Liam J. Thompson, Martin Boström, Clara Navarrete, John P McDonald, Erik Larsson, Roger Woodgate, Anders R Clausen
Nucleic acids research - 2019-01-01 -
Copy-choice recombination during mitochondrial L-strand synthesis causes DNA
deletions
Örjan Persson, Yazh Muthukumar, Swaraj Basu, Louise Jenninger, Jay (Jennifer) Uhler, Anna-Karin Berglund, R. McFarland, R. W. Taylor, Claes M Gustafsson, Erik Larsson, Maria Falkenberg
Nature Communications - 2019-01-01 -
Elevated pyrimidine dimer formation at distinct genomic bases underlies promoter mutation hotspots in UV-exposed
cancers.
Kerryn Elliott, Martin Boström, Stefan Filges, Markus Lindberg, Jimmy Van den Eynden, Anders Ståhlberg, Anders R Clausen, Erik Larsson
PLoS genetics - 2018-01-01 -
A patient-derived xenograft pre-clinical trial reveals treatment responses and a resistance mechanism to karonudib in metastatic
melanoma
Berglind Osk Einarsdottir, Joakim Karlsson, Elin Söderberg, Mattias F Lindberg, Elisa Funck-Brentano, Henrik Jespersen, Siggeir Fannar Brynjólfsson, Roger Olofsson Bagge, Louise Carstam, M. Scobie, T. Koolmeister, O. Wallner, Ulrika Stierner, U. W. Berglund, Lars Ny, Lisa M Nilsson, Erik Larsson, T. Helleday, Jonas A Nilsson
Cell Death & Disease - 2018-01-01 -
Phosphoproteome and gene expression profiling of ALK inhibition in neuroblastoma cell lines reveals conserved oncogenic
pathways.
Jimmy Van den Eynden, Ganesh Umapathy, Arghavan Ashouri, Diana Lizeth Cervantes-Madrid, Joanna Szydzik, Kristina Ruuth, Jan Koster, Erik Larsson, Jikui Guan, Ruth H. Palmer, Bengt Hallberg
Science signaling - 2018-01-01 -
An antisense RNA capable of modulating the expression of the tumor suppressor
microRNA-34a
J. T. Serviss, N. Andrews, Jimmy Van den Eynden, F. C. Richter, M. Houtman, M. Vesterlund, L. Schwarzmueller, P. Johnsson, Erik Larsson, D. Grander, K. P. Tamm
Cell Death & Disease - 2018-01-01 -
A Catalogue of Putative cis-Regulatory Interactions Between Long Non-coding RNAs and Proximal Coding Genes Based on Correlative Analysis Across Diverse Human
Tumors
Swaraj Basu, Erik Larsson
G3-Genes Genomes Genetics - 2018-01-01 -
Topoisomerase 3α Is Required for Decatenation and Segregation of Human
mtDNA
Thomas J. Nicholls, C. A. Nadalutti, E. Motori, E. W. Sommerville, G. S. Gorman, Swaraj Basu, Emily Hoberg, D. M. Turnbull, P. F. Chinnery, N. G. Larsson, Erik Larsson, Maria Falkenberg, R. W. Taylor, J. D. Griffith, Claes M Gustafsson
Molecular Cell - 2018-01-01 -
Transcriptomic Characterization of the Human Cell Cycle in Individual Unsynchronized
Cells.
Joakim Karlsson, Thomas Kroneis, Emma Jonasson, Erik Larsson, Anders Ståhlberg
Journal of molecular biology - 2017-01-01 -
Transcriptional profiling of the rat nucleus accumbens after modest or high alcohol
exposure
Julia Morud, Arghavan Ashouri, Erik Larsson, Mia Ericson, Bo Söderpalm
Plos One - 2017-01-01 -
Mutational signatures are critical for proper estimation of purifying selection pressures in cancer somatic mutation data when using the dN/dS
metric
Jimmy Van den Eynden, Erik Larsson
Frontiers in Genetics - 2017-01-01 -
Long noncoding RNAs are dynamically regulated during beta-cell mass expansion in mouse pregnancy and control beta-cell proliferation in
vitro
G. Sisino, A. X. Zhou, Niklas Dahr, A. Sabirsh, M. M. Soundarapandian, R. Perera, Erik Larsson, M. C. Magnone, M. Althage, B. Tyrberg
Plos One - 2017-01-01 -
Tumour virology in the era of high-throughput
genomics
Ka-Wei Tang, Erik Larsson
Philosophical Transactions of the Royal Society B-Biological Sciences - 2017-01-01 -
Recurrent promoter mutations in melanoma are defined by an extended context-specific mutational
signature
Nils J Fredriksson, Kerryn Elliott, Stefan Filges, Jimmy Van den Eynden, Anders Ståhlberg, Erik Larsson
Plos Genetics - 2017-01-01 -
Pan-cancer transcriptomic analysis associates long non-coding RNAs with key mutational driver
events
Arghavan Ashouri, Volkan I. Sayin, Jimmy Van den Eynden, S. X. Singh, T. Papagiannakopoulos, Erik Larsson
Nature Communications - 2016-01-01 -
Somatic Mutation Patterns in Hemizygous Genomic Regions Unveil Purifying Selection during Tumor
Evolution
Jimmy Van den Eynden, Swaraj Basu, Erik Larsson
Plos Genetics - 2016-01-01 -
Global analysis of somatic structural genomic alterations and their impact on gene expression in diverse human
cancers.
Babak Alaei-Mahabadi, Joydeep Bhadury, Joakim Karlsson, Jonas Nilsson, Erik Larsson
Proceedings of the National Academy of Sciences of the United States of America - 2016-01-01 -
FocalScan: Scanning for altered genes in cancer based on coordinated DNA and RNA
change.
Joakim Karlsson, Erik Larsson
Nucleic acids research - 2016-01-01 -
Searching the Evolutionary Origin of Epithelial Mucus Protein Components-Mucins and
FCGBP
Tiange Lang, Sofia Klasson, Erik Larsson, Malin E V Johansson, Gunnar C. Hansson, Tore Samuelsson
Molecular Biology and Evolution - 2016-01-01 -
Deficiency of filamin A in endothelial cells impairs left ventricular remodeling after myocardial
infarction.
Sashidar Bandaru, Julia Grönros, Björn Redfors, Cağlar Cil, David Pazooki, Reza Salimi, Erik Larsson, Alex-Xianghua Zhou, Elmir Omerovic, Levent Akyürek
Cardiovascular Research - 2015-01-01 -
Simultaneous DNA and RNA Mapping of Somatic Mitochondrial Mutations across Diverse Human
Cancers.
James B Stewart, Babak Alaei-Mahabadi, Radhakrishnan Sabarinathan, Tore Samuelsson, Jan Gorodkin, Claes M Gustafsson, Erik Larsson
PLoS genetics - 2015-01-01 -
The gut microbiota modulates host amino acid and glutathione metabolism in
mice
Adil Mardinoglu, Saeed Shoaie, Mattias Bergentall, Pouyan Ghaffari Nouran, C. Zhang, Erik Larsson, Fredrik Bäckhed, Jens B. Nielsen
Molecular Systems Biology - 2015-01-01 -
The Cell Cycle Regulator CCDC6 Is a Key Target of RNA-Binding Protein
EWS.
Sujitha Duggimpudi, Erik Larsson, Schafiq Nabhani, Arndt Borkhardt, Jessica I Hoell
PloS one - 2015-01-01 -
Absence of cytomegalovirus in high-coverage DNA sequencing of human glioblastoma
multiforme.
Ka-Wei Tang, Kristoffer Hellstrand, Erik Larsson
International journal of cancer. Journal international du cancer - 2015-01-01 -
Antioxidants accelerate lung cancer progression in
mice.
Volkan I. Sayin, Mohamed X Ibrahim, Erik Larsson, Jonas A Nilsson, Per Lindahl, Martin Bergö
Science translational medicine - 2014-01-01 -
The risk-associated long noncoding RNA NBAT-1 controls neuroblastoma progression by regulating cell proliferation and neuronal
differentiation.
Gaurav Kumar Pandey, Sanhita Mitra, Santhilal Subhash, Falk Hertwig, Meena Kanduri, Kankadeb Mishra, Susanne Fransson, Abiarchana Ganeshram, Tanmoy Mondal, Sashidar Bandaru, Malin Östensson, Levent Akyürek, Jonas Abrahamsson, Susan Pfeifer, Erik Larsson, Leming Shi, Zhiyu Peng, Matthias Fischer, Tommy Martinsson, Fredrik Hedborg, Per Kogner, Chandrasekhar Kanduri
Cancer Cell - 2014-01-01 -
LC-MS/MS characterization of combined glycogenin-1 and glycogenin-2 enzymatic activities reveals their self-glucosylation
preferences.
Johanna Nilsson, Adnan Halim, Erik Larsson, Ali-Reza Moslemi, Anders Oldfors, Göran Larson, Jonas Nilsson
Biochimica et biophysica acta - 2014-01-01 -
Systematic analysis of noncoding somatic mutations and gene expression alterations across 14 tumor
types.
Nils J Fredriksson, Lars Ny, Jonas A Nilsson, Erik Larsson
Nature genetics - 2014-01-01 -
Temporal separation of replication and transcription during S-phase
progression.
Meryet-Figuiere Matthieu, Babak Alaei-Mahabadi, Moustafa Ali Mohamad, Sanhita Mitra, Santhilal Subhash, Gaurav Kumar Pandey, Erik Larsson, Chandrasekhar Kanduri
Cell Cycle - 2014-01-01 -
Identification of the RNA recognition element of the RBPMS family of RNA-binding proteins and their transcriptome-wide mRNA
targets.
Thalia A Farazi, Carl S Leonhardt, Neelanjan Mukherjee, Aleksandra Mihailovic, Song Li, Klaas E A Max, Cindy Meyer, Masashi Yamaji, Pavol Cekan, Nicholas C Jacobs, Stefanie Gerstberger, Claudia Bognanni, Erik Larsson, Uwe Ohler, Thomas Tuschl
RNA (New York, N.Y.) - 2014-01-01 -
Zfp148 Deficiency Causes Lung Maturation Defects and Lethality in Newborn Mice That Are Rescued by Deletion of p53 or Antioxidant
Treatment
Volkan I. Sayin, Anna Nilton, Mohamed X Ibrahim, Pia Ågren, Erik Larsson, Marleen MR Petit, Lillemor Mattsson Hultén, Marcus Ståhlman, Bengt R Johansson, Martin Bergö, Per Lindahl
Plos One - 2013-01-01 -
Zinc Finger Protein 148 Is Dispensable for Primitive and Definitive Hematopoiesis in
Mice
Anna Nilton, Volkan I. Sayin, Anna Staffas, Erik Larsson, Julia Rolf, Marleen MR Petit, Lars Palmqvist, Birgitta Swolin, Susanna Cardell, Per Lindahl
Plos One - 2013-01-01 -
MicroRNA-24 Suppression of N-Deacetylase/N-Sulfotransferase-1 (NDST1) Reduces Endothelial Cell Responsiveness to Vascular Endothelial Growth Factor A
(VEGFA)
Z. Kasza, P. F. Fuchs, C. Tamm, A. S. Eriksson, P. O'Callaghan, F. Heindryckx, D. Spillmann, Erik Larsson, S. Le Jan, I. Eriksson, P. Gerwins, L. Kjellen, J. Kreuger
Journal of Biological Chemistry - 2013-01-01 -
Hypertension and Genetic Variation in Endothelial-Specific
Genes
Erik Larsson, Björn Wahlstrand, B. Hedblad, Thomas Hedner, S. E. Kjeldsen, O. Melander, Per Lindahl
Plos One - 2013-01-01 -
Comprehensive Analysis of Long Non-Coding RNAs in Ovarian Cancer Reveals Global Patterns and Targeted DNA
Amplification.
Rozita Akrami, Anders Jacobsen, Jessica Hoell, Nikolaus Schultz, Chris Sander, Erik Larsson
PloS one - 2013-01-01 -
The landscape of viral expression and host gene fusion and adaptation in human
cancer
Ka-Wei Tang, Babak Alaei-Mahabadi, Tore Samuelsson, Magnus Lindh, Erik Larsson
Nature Communications - 2013-01-01 -
Limited evidence for evolutionarily conserved targeting of long non-coding RNAs by
microRNAs.
Babak Alaei-Mahabadi, Erik Larsson
Silence - 2013-01-01 -
Integrative Analysis of Complex Cancer Genomics and Clinical Profiles Using the
cBioPortal
J. J. Gao, B. A. Aksoy, U. Dogrusoz, G. Dresdner, B. Gross, S. O. Sumer, Y. C. Sun, A. Jacobsen, R. Sinha, Erik Larsson, E. Cerami, C. Sander, N. Schultz
Science Signaling - 2013-01-01 -
The non-coding oncogene: a case of missing DNA
evidence?
Erik Larsson, Puja Shahrouki
Frontiers in Genetics - 2012-01-01 -
Analysis of gut microbial regulation of host gene expression along the length of the gut and regulation of gut microbial ecology through
MyD88
Erik Larsson, Valentina Tremaroli, Ying Shiuan Lee, Omry Koren, Intawat Nookaew, Ashwana Fricker, Jens B. Nielsen, Ruth E Ley, Fredrik Bäckhed
Gut - 2012-01-01 -
Integrated analyses of microRNAs demonstrate their widespread influence on gene expression in high-grade serous ovarian
carcinoma.
Chad J Creighton, Anadulce Hernandez-Herrera, Anders Jacobsen, Douglas A Levine, Parminder Mankoo, Nikolaus Schultz, Ying Du, Yiqun Zhang, Erik Larsson, Robert Sheridan, Weimin Xiao, Paul T Spellman, Gad Getz, David A Wheeler, Charles M Perou, Richard A Gibbs, Chris Sander, D Neil Hayes, Preethi H Gunaratne
PloS one - 2012-01-01 -
The cBio cancer genomics portal: an open platform for exploring multidimensional cancer genomics
data.
Ethan Cerami, Jianjiong Gao, Ugur Dogrusoz, Benjamin E Gross, Selcuk Onur Sumer, Bülent Arman Aksoy, Anders Jacobsen, Caitlin J Byrne, Michael L Heuer, Erik Larsson, Yevgeniy Antipin, Boris Reva, Arthur P Goldberg, Chris Sander, Nikolaus Schultz
Cancer discovery - 2012-01-01 -
miRcode: a map of putative microRNA target sites in the long non-coding
transcriptome
Ashwini Jeggari, D. S. Marks, Erik Larsson
Bioinformatics - 2012-01-01 -
Superoxide dismutase 1 (SOD1) is a target for a small molecule identified in a screen for inhibitors of the growth of lung adenocarcinoma cell
lines.
Erik Larsson
Proceedings of the National Academy of Science of the United States of America - 2011-01-01 -
RNA targets of wild-type and mutant FET family
proteins
Erik Larsson
Nature Structural & Molecular Biology - 2011-01-01 -
Cyclosporine does not reduce myocardial infarct size in a porcine ischemia-reperfusion
model.
Lars O Karlsson, Xianghua Zhou, Erik Larsson, Karin Åström-Olsson, Chrichan Månsson, Levent Akyürek, Lars Grip
Journal of Cardiovascular Pharmacology and Therapeutics - 2010-01-01 -
Endothelial cells are activated during hypoxia via endoglin/ALK-1/SMAD1/5 signaling in vivo and in
vitro.
Fei Tian, Xianghua Zhou, Anke M Smits, Erik Larsson, Marie-José Goumans, Carl-Henrik Heldin, Jan Borén, Levent Akyürek
Biochemical and Biophysical Research Communications - 2010-01-01 -
Target mRNA abundance dilutes microRNA and siRNA
activity
Aaron Arvey, Erik Larsson, Christina Leslie, Chris Sander, Debora Marks
Molecular Systems Biology - 2010-01-01 -
mRNA turnover rate limits siRNA and microRNA
efficacy.
Erik Larsson, Chris Sander, Debora Marks
Molecular Systems Biology - 2010-01-01 -
Vascular endothelial growth factor B controls endothelial fatty acid
uptake.
Carolina E Hagberg, Annelie Falkevall, Xun Wang, Erik Larsson, Jenni Huusko, Ingrid Nilsson, Laurens A van Meeteren, Erik Samen, Li Lu, Maarten Vanwildemeersch, Joakim Klar, Guillem Genove, Kristian Pietras, Sharon Stone-Elander, Lena Claesson-Welsh, Seppo Ylä-Herttuala, Per Lindahl, Ulf Eriksson
Nature - 2010-01-01 -
The SNARE protein SNAP23 and the SNARE-interacting protein Munc18c in human skeletal muscle are implicated in insulin resistance/type 2
diabetes.
Pontus Boström, Linda Andersson, Birgitte Vind, Liliana Håversen, Mikael Rutberg, Ylva Wickström, Erik Larsson, Per-Anders Jansson, M.K Svensson, Rickard Brånemark, Charlotte Ling, Henning Beck-Nielsen, Jan Borén, Kurt Højlund, Sven-Olof Olofsson
Diabetes - 2010-01-01 -
Hypoxic regulation of secreted proteoglycans in
macrophages.
Annika Asplund, Pia Stillemark-Billton, Erik Larsson, Ellen Knutsen Rydberg, Jonatan Moses, Lillemor Mattsson Hultén, Björn Fagerberg, German Camejo, Göran Bondjers
Glycobiology - 2010-01-01 -
Transcriptional profiling reveals a critical role for tyrosine phosphatase VE-PTP in regulation of VEGFR2 activity and endothelial cell
morphogenesis.
Sofie Mellberg, Anna Dimberg, Fuad Bahram, Makoto Hayashi, Emma Rennel, Adam Ameur, Jakub Orzechowski Westholm, Erik Larsson, Per Lindahl, Michael J Cross, Lena Claesson-Welsh
The FASEB journal - 2009-01-01 -
Discovery of microvascular miRNAs using public gene expression data: miR-145 is expressed in pericytes and is a regulator of
Fli1.
Erik Larsson, Peder Fredlund Fuchs, Johan Heldin, Irmeli Barkefors, Cecilia Bondjers, Guillem Genové, Christelle Arrondel, Pär Gerwins, Christine Kurschat, Bernhard Schermer, Thomas Benzing, Scott J Harvey, Johan Kreuger, Per Lindahl
Genome medicine - 2009-01-01 -
Regulation of gene expression in the vascular
wall
Erik Larsson
- 2009-01-01 -
Do two mutually exclusive gene modules define the phenotypic diversity of mammalian smooth
muscle?
Erik Larsson, Sean E McLean, Robert P Mecham, Per Lindahl, Sven Nelander
Molecular genetics and genomics : MGG - 2008-01-01 -
Smooth muscle expression of lipoma preferred partner is mediated by an alternative intronic promoter that is regulated by serum response
factor/myocardin.
Marleen MR Petit, Henrik Lindskog, Erik Larsson, Per Wasteson, Elisabet Athley, Silke Breuer, Meike Angstenberger, David Hertfelder, Erney Mattsson, Alfred Nordheim, Sven Nelander, Per Lindahl
Circulation research - 2008-01-01 -
Identification of a core set of 58 gene transcripts with broad and specific expression in the
microvasculature.
Elisabet Wallgard, Erik Larsson, Liqun He, Mats Hellström, Annika Armulik, Maya H Nisancioglu, Guillem Genove, Per Lindahl, Christer Betsholtz
Arteriosclerosis, thrombosis, and vascular biology - 2008-01-01 -
RhoA-dependent vascular smooth muscle cell-specific transcription: adding diaphanous formins to the
puzzle.
Erik Larsson, Xianghua Zhou, Levent Akyürek
Arteriosclerosis, Thrombosis, and Vascular Biology - 2007-01-01 -
HeliCis: a DNA motif discovery tool for colocalized motif pairs with periodic
spacing.
Erik Larsson, Per Lindahl, Petter Mostad
BMC Bioinformatics - 2007-01-01 -
New insights to vascular smooth muscle cell and pericyte differentiation of mouse embryonic stem cells in
vitro.
Henrik Lindskog, Elisabet Athley, Erik Larsson, Samuel B Lundin, Mats Hellström, Per Lindahl
Arteriosclerosis, thrombosis, and vascular biology - 2006-01-01 -
Predictive screening for regulators of conserved functional gene modules (gene batteries) in
mammals
Sven Nelander, Erik Larsson, Erik Kristiansson, Robert Månsson, Olle Nerman, Mikael Sigvardsson, Petter Mostad, Per Lindahl
BMC genomics - 2005-01-01