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Per-Anders Jansson
Professor/ Chief Physician
Department of Molecular and Clinical MedicineAbout Per-Anders Jansson
Dr Per-Anders Jansson is board certified in General Internal Internal Medicine, awarded University Hospital Senior Consultant and Professor in Translational Medical Research at the University of Gothenburg.
He is an expert on mechanisms behind insulin resistance in prediabetes/type 2 diabetes. The overall aim of his work is to elucidate the metabolic impact of vascular insulin-resistance and to implement novel strategies to prevent and treat type 2 diabetes.
Dr Jansson held a position as 50% Clinical Researcher at the Swedish Research Council 2006-2011 and from 2014 he is Professor at the Sahlgrenska Academy and 30% medical adviser Gothia Forum, Sahlgrenska University Hospital, region Västra Götaland.
Main research: breaking the "insulin barrier"
Type 2 diabetes blocks the bloodstream’s ability to distribute insulin to its target cells. That basic malfunction contributing to insulin-resistance makes one in five of us developing the disease at some stage in our lives and cases rising steadily. The IRVASC project, led by Per-Anders Jansson, aims to find out why.
The latest research project, Insulin Resistance Mechanisms in Human Vasculature (IRVASC) aims to answer a big question: what is it about the way the vascular system operates in humans that can cause it to block the very insulin it needs to distribute for the body’s survival? With nine out of ten diabetes patients having type 2, it is overwhelmingly the most prevalent form worldwide. Unlike type 1, where the pancreas fails to make insulin in the first place, type 2 largely involves lack of biologic effects of the insulin that is made – a malfunction known as insulin-resistance.
So we know what happens – but why? To this end, our group is focusing the research on three vascular-related issues: firstly, why does the capillary wall act as a barrier to transfer the insulin into the tissue; secondly, why doesn’t the bloodstream carry insulin to the cells – how do you improve blood flow sufficiently? And thirdly why do muscle cells and fat cells around the body then resist to respond when insulin finally have reached the target cell?
Our group has seen some progress with the compound tadalafil.We’re especially looking at the role of microvascular capillary recruitment after a meal. In a healthy body, blood flow increases after a meal, to distribute insulin to cells. But with type 2, blood flow is impaired and insulin is not distributed to cells in the periphery. Methodology for these studies involves taking adipose tissue samples from patients and healthy control groups and isolating microvascular cells in each. The aim is to discover the mechanism the vascular cells use to transport insulin through the capillary wall, and thus what is failing in the mechanism in diabetes patients.
Our group has seen some progress with the compound tadalafil. This was originally a drug used to combat impotence because it increases blood flow. But we’re seeing encouraging metabolic results when using it to increase blood flow in other areas too. We still need more data on this so it’s an area we will keep pursuing. Though our team is some way off understanding the complete mechanics of the insulin barrier, there has been significant progress towards this goal too. We have then been able to show that insulin-resistance is associated with an impaired signalling system in the key protein downstream the insulin receptor within the microvascular endothelium.
Ultimately, we all have one aim – to identify and understand the various factors that cause type 2 diabetes and find a way of preventing a disease that can show itself at any stage in a person’s life. Because at best it is a disease dramatically reducing the quality of life for millions of people around the world. At worst it is threatening the lives of millions more.
Group Members
- Annika Johansson, Research Nurse
- Emanuel Fryk, Practising physician combined with research
- Maria Just, Research Nurse
- Lena Strindberg, BMA, Research Associate
- Vagner Ramon Rodrigues Silva, Post doc
- Barbara Becattini, Researcher
Funding
The annual funding from the ALF-agreement, Medical research Council, Swedish Diabetes Association, and other external funding approximately 2.5 MSEK.
Key Publications
- Mobini R, Tremaroli V, Ståhlman M, Karlsson F, Levin M, Ljungberg M, Schmelz M, Berteus Forslund H, Perkins R, Bäckhed F, Jansson P-A. Metabolic effects ofL. ReuteriDSM 17938 in people with type 2 diabetes: a randomized controlled trial.
- Fryk E, Perman Sundelin J, Strindberg L, Pereira M, Federici M, Marx N, Nyström F, Schmelz M, Svensson P-A, Eriksson J, Borén J, Jansson P-A. Microdialysis and proteomics of the subcutaneous interstitial fluid reveals abundance of galectin-1 in type 2 diabetes patients. Metabolism 65:998-1006 (2016).
- Jansson P-A, Murdolo G, Sjögren L, Nyström B, Sjöstrand M, Strindberg L, Lönnroth P. Phosphodiesterase-5 inhibition increases muscle capillary recruitment and forearm glucose uptake in type 2 diabetes patients. Diabetologia 2010:53:2205-8.
- Eriksson JW, Smith U, Waagstein F, Wysocki M, Jansson PA. Glucose turnover and adipose tissue lipolysis are insulin-resistant in healthy relatives of type 2 diabetes patients: is cellular insulin resistance a secondary phenomenon? Diabetes 48:1572-8 (1999).
- Jansson P-A, Larsson A, Smith U, Lönnroth P. Glycerol production in subcutaneous adipose tissue in lean and obese humans. J Clin Invest 89:1610-17, 1992
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Insulin Hypersecretion as Promoter of Body Fat Gain and
Hyperglycemia.
Bettina Mittendorfer, James D Johnson, Giovanni Solinas, Per-Anders Jansson
Diabetes - 2024 -
Cardiorespiratory fitness and the association with galectin-1 in middle-aged
individuals
Daniel Arvidsson, Vagner Ramon Rodrigues Silva, Orjan Ekblom, Elin Ekblom-Bak, Emanuel Fryk, Per-Anders Jansson, Mats Börjesson
PLOS ONE - 2024 -
Baseline levels of circulating galectin-1 associated with radiographic hand but not radiographic knee osteoarthritis at a two-year
follow-up
M. L. E. Andersson, M. Zimmerman, E. Brogren, Stefan Bergman, Lena Strindberg, Emanuel Fryk, Per-Anders Jansson
OSTEOARTHRITIS AND CARTILAGE OPEN - 2024 -
Galectin-1 correlates with inflammatory markers and T regulatory cells in children with type 1 diabetes and/or celiac
disease
Emanuel Fryk, Asa Wilsson, Andrea Tompa, Per-Anders Jansson, Maria Faresjo
CLINICAL AND EXPERIMENTAL IMMUNOLOGY - 2024 -
Osteoblast-lineage cells regulate metabolism and fat
mass
Daniel Hägg, Per-Anders Jansson, Jakob Bellman, John-Olov Jansson, Claes Ohlsson
Current Opinion in Endocrine and Metabolic Research - 2023 -
The dual hypothesis of homeostatic body weight regulation, including gravity-dependent and leptin-dependent
actions.
John-Olov Jansson, Fredrik Anesten, Daniel Hägg, Jovana Zlatowic, Suzanne L. Dickson, Per-Anders Jansson, Erik Schéle, Jakob Bellman, Claes Ohlsson
Philosophical transactions of the Royal Society of London. Series B, Biological sciences - 2023 -
Feasibility of high-dose tadalafil and effects on insulin resistance in well-controlled patients with type 2 diabetes (MAKROTAD): a single-centre, double-blind, randomised, placebo-controlled, cross-over phase 2
trial
Emanuel Fryk, Vagner Ramon Rodrigues Silva, Marco Bauzá-Thorbrügge, M. Schmelz, Li-Ming Gan, Lena Strindberg, Per-Anders Jansson
Eclinicalmedicine - 2023 -
Glucose Homeostasis in Relation to Neutrophil Mobilization in Smokers with
COPD
N. Pournaras, Anders Andersson, M. A. Kovach, Médea Padra, K. F. Che, B. Brundin, S. Yoshihara, S. Bozinovski, Sara K. Lindén, Per-Anders Jansson, M. C. Skold, Ingemar Qvarfordt, A. Linden
International Journal of Chronic Obstructive Pulmonary Disease - 2022 -
Performance of Dexcom G5 and FreeStyle Libre sensors tested simultaneously in people with type 1 or 2 diabetes and advanced chronic kidney
disease
Arndis Olafsdottir, M. Andelin, Aso Saeed, S. Sofizadeh, H. Hamoodi, Per-Anders Jansson, Marcus Lind
World Journal of Clinical Cases - 2022 -
Somatic ablation of IKKβ in liver and leukocytes is not tolerated in obese mice but hepatic IKKβ deletion improves fatty liver and insulin
sensitivity.
Vagner Ramon Rodrigues Silva, Angela Molinaro, Andrea Usseglio Gaudi, Emanuel Fryk, Claudia Sardi, Maria Hammarlund, Filip Mjörnstedt, Maria E Johansson, Barbara Becattini, Per-Anders Jansson, Giovanni Solinas
FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 2022 -
The role of the platelet pool of Plasminogen Activator Inhibitor-1 in well-controlled type 2 diabetes
patients
Karin Mossberg, Josefin Olausson, Emanuel Fryk, Sverker Jern, Per-Anders Jansson, Helén Brogren
Plos One - 2022 -
The role of circulating galectin-1 in type 2 diabetes and chronic kidney disease: evidence from cross-sectional, longitudinal and Mendelian randomisation
analyses
I. Drake, Emanuel Fryk, Lena Strindberg, Annika Lundqvist, Anders H. Rosengren, L. Groop, E. Ahlqvist, Jan Borén, M. Orho-Melander, Per-Anders Jansson
Diabetologia - 2022 -
Galectin-1 in Obesity and Type 2
Diabetes
Emanuel Fryk, Vagner Ramon Rodrigues Silva, Per-Anders Jansson
Metabolites - 2022 -
Identification of human glucocorticoid response markers using integrated multi-omic analysis from a randomized crossover
trial.
Dimitrios Chantzichristos, Per-Arne Svensson, Terence Garner, Camilla A M Glad, Brian R Walker, Ragnhildur Bergthorsdottir, Oskar Ragnarsson, Penelope Trimpou, Roland H Stimson, Stina W Borresen, Ulla Feldt-Rasmussen, Per-Anders Jansson, Stanko Skrtic, Adam Stevens, Gudmundur Johannsson
eLife - 2021 -
Literature review: Evidence-based health outcomes and perceptions of the built environment in pediatric hospital
facilities.
Emelie Pauli Bock, Stefan Nilsson, Per-Anders Jansson, Helle Wijk, Eirini Alexiou, Göran Lindahl, Malin Berghammer, Alessio Degl'Innocenti
Journal of pediatric nursing - 2021 -
Circulating endothelin-1 levels are positively associated with chronic kidney disease in women but not in men: a longitudinal study in the Vara-Skovde
cohort
Margareta Hellgren, Per-Anders Jansson, Hormoz Alayar, Ulf Lindblad, Bledar Daka
Bmc Nephrology - 2021 -
Hyperinsulinemia and insulin resistance in the obese may develop as part of a homeostatic response to elevated free fatty acids: A mechanistic case-control and a population-based cohort
study
Emanuel Fryk, Josefin Olausson, Karin Mossberg, Lena Strindberg, M. Schmelz, Helén Brogren, L. M. Gan, S. Piazza, A. Provenzani, Barbara Becattini, L. Lind, Giovanni Solinas, Per-Anders Jansson
Ebiomedicine - 2021 -
Longitudinal plasma protein profiling of newly diagnosed type 2
diabetes.
Anders Gummesson, Elias Björnson, Linn Fagerberg, Wen Zhong, Abdellah Tebani, Fredrik Edfors, Caroline Schmidt, Annika Lundqvist, Martin Adiels, Fredrik Bäckhed, Jochen M Schwenk, Per-Anders Jansson, Mathias Uhlén, Göran Bergström
EBioMedicine - 2021 -
Integration of molecular profiles in a longitudinal wellness profiling
cohort.
Abdellah Tebani, Anders Gummesson, Wen Zhong, Ina Schuppe Koistinen, Tadepally Lakshmikanth, Lisa M. Olsson, Fredrik Boulund, Maja Neiman, Hans Stenlund, Cecilia Hellström, Max J Karlsson, Muhammad Arif, Tea Dodig-Crnkovic, Adil Mardinoglu, Sunjae Lee, Cheng Zhang, Yang Chen, Axel Olin, Jaromir Mikes, Hanna Danielsson, Kalle von Feilitzen, Per-Anders Jansson, Oskar Angerås, Mikael Huss, Sanela Kjellqvist, Jacob Odeberg, Fredrik Edfors, Valentina Tremaroli, Björn Forsström, Jochen M Schwenk, Peter Nilsson, Thomas Moritz, Fredrik Bäckhed, Lars Engstrand, Petter Brodin, Göran Bergström, Mathias Uhlen, Linn Fagerberg
Nature communications - 2020 -
Wide QRS-T angles are associated with markers of increased inflammatory activity independently of hypertension and
diabetes.
Mikael Sandstedt, Lennart Bergfeldt, Joakim Sandstedt, Annika Lundqvist, Emanuel Fryk, Per-Anders Jansson, Göran Bergström, Lillemor Mattsson Hultén
Annals of noninvasive electrocardiology : the official journal of the International Society for Holter and Noninvasive Electrocardiology, Inc - 2020 -
Increased weight loading reduces body weight and body fat in obese subjects – A proof of concept randomized clinical
trial
Claes Ohlsson, Edwin Gidestrand, Jakob Bellman, Christel Larsson, Vilborg Palsdottir, Daniel Hägg, Per-Anders Jansson, John-Olov Jansson
EClinicalMedicine - 2020 -
Probiotic treatment using a mix of three Lactobacillus strains for lumbar spine bone loss in postmenopausal women: a randomised, double-blind, placebo-controlled, multicentre
trial
Per-Anders Jansson, D. Curiac, I. L. Ahren, F. Hansson, T. M. Niskanen, Klara Sjögren, Claes Ohlsson
Lancet Rheumatology - 2019 -
Plasma metabolomic patterns in patients with exhaustion
disorder
Jenny Hadrévi, Ingibjörg H Jonsdottir, Per-Anders Jansson, Jan W. Eriksson, Anna Sjörs
Stress - 2019 -
Effects of free omega-3 carboxylic acids and fenofibrate on liver fat content in patients with hypertriglyceridemia and non-alcoholic fatty liver disease: A double-blind, randomized, placebo-controlled
study.
Jan Oscarsson, Kristina Önnerhag, Ulf Risérus, Mattias Sundén, Lars Johansson, Per-Anders Jansson, Linda Moris, Peter M Nilsson, Jan W Eriksson, Lars Lind
Journal of clinical lipidology - 2018 -
Effects of dapagliflozin and n-3 carboxylic acids on non-alcoholic fatty liver disease in people with type 2 diabetes: a double-blind randomised placebo-controlled
study
J. W. Eriksson, P. Lundkvist, Per-Anders Jansson, L. Johansson, M. Kvarnstrom, L. Moris, T. Miliotis, G. B. Forsberg, U. Riserus, L. Lind, J. Oscarsson
Diabetologia - 2018 -
Metabolic effects of Lactobacillus reuteri DSM 17938 in people with type 2 diabetes: A randomized controlled
trial
Reza Mobini, Valentina Tremaroli, Marcus Ståhlman, F. Karlsson, Max Levin, Maria Ljungberg, Maja Sohlin, Helene Berteus Forslund, Rosie Perkins, Fredrik Bäckhed, Per-Anders Jansson
Diabetes Obesity & Metabolism - 2017 -
Postprandial effects of the phosphodiesterase-5 inhibitor tadalafil in people with well-controlled Type 2 diabetes mellitus: a randomized controlled
trial.
Lovisa Sjögren, Josefin Olausson, Lena Strindberg, Reza Mobini, Per Fogelstrand, Lillemor Mattsson Hultén, Per-Anders Jansson
Diabetic medicine : a journal of the British Diabetic Association - 2016 -
Microdialysis and proteomics of subcutaneous interstitial fluid reveals increased galectin-1 in type 2 diabetes
patients
Emanuel Fryk, Jeanna Perman Sundelin, Lena Strindberg, Maria J Pereira, M. Federici, N. Marx, Helena Filipsson Nyström, M. Schmelz, Per-Arne Svensson, Jan W Eriksson, Jan Borén, Per-Anders Jansson
Metabolism-Clinical and Experimental - 2016 -
Endothelin-1 as a predictor of impaired glucose tolerance and type 2 diabetes - A longitudinal study in the Vara-Skovde
Cohort
Josefin Olausson, Bledar Daka, Margareta Hellgren, Charlotte A. Larsson, Max Petzold, Ulf Lindblad, Per-Anders Jansson
Diabetes Research and Clinical Practice - 2016 -
C-Reactive Protein Concentrations and Level of Physical Activity in Men and Women With Normal and Impaired Glucose Tolerance: A Cross-Sectional Population-Based Study in
Sweden
Margareta Hellgren, Charlotte A. Larsson, Bledar Daka, Max Petzold, Per-Anders Jansson, Ulf Lindblad
Journal of Physical Activity & Health - 2016 -
A lifestyle intervention in primary care prevents deterioration of insulin resistance in patients with impaired glucose tolerance: A randomised controlled
trial.
Margareta Hellgren, Per-Anders Jansson, Hans Wedel, Ulf Lindblad
Scandinavian journal of public health - 2016 -
A Genome-Wide mQTL Analysis in Human Adipose Tissue Identifies Genetic Variants Associated with DNA Methylation, Gene Expression and Metabolic
Traits
P. Volkov, A. H. Olsson, L. Gillberg, S. W. Jorgensen, C. Brons, K. F. Eriksson, L. Groop, Per-Anders Jansson, E. Nilsson, T. Ronn, A. Vaag, C. Ling
Plos One - 2016 -
Circulating concentrations of endothelin-1 predict coronary heart disease in women but not in men: A longitudinal observational study in the Vara-Skövde
Cohort
Bledar Daka, Josefin Olausson, Charlotte A. Larsson, Margareta Hellgren, Lennart Råstam, Per-Anders Jansson, Ulf Lindblad
BMC Cardiovascular Disorders - 2015 -
Low concentrations of serum testosterone predict acute myocardial infarction in men with type 2 diabetes
mellitus
Bledar Daka, R. D. Langer, C. A. Larsson, Thord Rosén, Per-Anders Jansson, L. Rastam, Ulf Lindblad
Bmc Endocrine Disorders - 2015 -
Primary care screening for individuals with impaired glucose metabolism with focus on impaired glucose
tolerance
Margareta Hellgren, Bledar Daka, Per-Anders Jansson, Ulf Lindblad
Primary Care Diabetes - 2015 -
Insulin resistance predicts early cardiovascular morbidity in men without diabetes mellitus, with effect modification by physical
activity
Margareta Hellgren, Bledar Daka, Per-Anders Jansson, Ulf Lindblad, Charlotte A. Larsson
European Journal of Preventive Cardiology - 2015 -
Impact of age, BMI and HbA1c levels on the genome-wide DNA methylation and mRNA expression patterns in human adipose tissue and identification of epigenetic biomarkers in
blood
T Rönn, P Volkov, L Gillberg, Milana Kokosar, A Perfilyev, AL Jacobsen, SW Jörgensen, C Bröns, Per-Anders Jansson, KF Eriksson, O Pedersen, T Hansen, L Groop, Elisabet Stener-Victorin, A Vaag, Emma Nilsson, Charlotte Ling
Human Molecular Genetics - 2015 -
Feasibility of a randomized controlled intervention with physical activity in participants with impaired glucose tolerance recruited by FINDRISC: A pilot
study
Margareta Hellgren, Max Petzold, Helene Berteus Forslund, H. Wedel, Per-Anders Jansson, Ulf Lindblad
Scandinavian Journal of Public Health - 2014 -
Altered DNA Methylation and Differential Expression of Genes Influencing Metabolism and Inflammation in Adipose Tissue From Subjects With Type 2
Diabetes
E. Nilsson, Per-Anders Jansson, A. Perfilyev, P. Volkov, M. Pedersen, Maria K Svensson, P. Poulsen, R. Ribel-Madsen, N. L. Pedersen, P. Almgren, J. Fadista, T. Ronn, B. K. Pedersen, C. Scheele, A. Vaag, C. Ling
Diabetes - 2014 -
Inverse association between serum insulin and sex hormone-binding globulin in a population survey in
Sweden
Bledar Daka, Thord Rosén, Per-Anders Jansson, Råstam Lennart, Charlotte A. Larsson, Ulf Lindblad
Endocrine Connections - 2013 -
Low sex hormone-binding globulin is associated with hypertension: a cross-sectional study in a Swedish
population
Bledar Daka, Thord Rosén, Per-Anders Jansson, Charlotte A Larsson, Lennart Råstam, Ulf Lindblad
BMC Cardiovascular Disorders - 2013 -
Macrophage Gene Expression in Adipose Tissue is Associated with Insulin Sensitivity and Serum Lipid Levels Independent of
Obesity.
Sofie Ahlin, Kajsa Sjöholm, Peter Jacobson, Johanna C. Andersson-Assarsson, A Walley, J Tordjman, C Poitou, E Prifti, Per-Anders Jansson, Jan Borén, Lars Sjöström, P Froguel, R N Bergman, Lena M S Carlsson, Bob Olsson, Per-Arne Svensson
Obesity (Silver Spring, Md.) - 2013 -
Decreased Permeability Surface Area for Glucose in Obese Women with Postprandial Hyperglycemia: No Effect of Phosphodiesterase-5 (PDE-5)
Inhibition
Madelene Sandqvist, Lena Strindberg, Peter Lönnroth, Per-Anders Jansson
Hormone and Metabolic Research - 2013 -
The Selective Phosphodiesterase-5 Inhibitor Tadalafil Induces Microvascular and Metabolic Effects in Type 2 Diabetic Postmenopausal
Females
G. Murdolo, M. Sjostrand, Lena Strindberg, Peter Lönnroth, Per-Anders Jansson
Journal of Clinical Endocrinology & Metabolism - 2013 -
Increased insulin secretion and decreased glucose concentrations, but not allostatic load, are associated with stress-related exhaustion in a clinical patient
population
A. Sjors, Per-Anders Jansson, Jan W Eriksson, Ingibjörg H Jonsdottir
Stress-the International Journal on the Biology of Stress - 2013 -
Feasibility of the FINDRISC questionnaire to identify individuals with impaired glucose tolerance in Swedish primary care. A cross-sectional population-based
study.
Margareta Hellgren, Max Petzold, Cecilia Björkelund, Hans Wedel, Per-Anders Jansson, Ulf Lindblad
Diabetic Medicine - 2012 -
Impaired delivery of insulin to adipose tissue and skeletal muscle in obese women with postprandial
hyperglycemia.
Madelene Sandqvist, Lena Strindberg, M Schmelz, Peter Lönnroth, Per-Anders Jansson
The Journal of clinical endocrinology and metabolism - 2011 -
Glucose tolerance, insulin sensitivity and insulin release in European non-diabetic carriers of a polymorphism upstream of CDKN2A and
CDKN2B
M. L. Hribal, I. Presta, T. Procopio, M. A. Marini, A. Stancakova, J. Kuusisto, F. Andreozzi, Ann Hammarstedt, Per-Anders Jansson, N. Grarup, T. Hansen, M. Walker, N. Stefan, A. Fritsche, H. U. Haring, O. Pedersen, Ulf Smith, M. Laakso, G. Sesti
Diabetologia - 2011 -
Hydrochlorothiazide compared to candesartan treatment increases adipose tissue gene expression and circulating levels of serum amyloid A in hypertensive
patients.
Jenny Palming, Per-Anders Jansson, Frida Renström, Aino Johansson, Lars Johansson, Cecilia Karlsson, Lars Lind, Jan W Eriksson
Hormone and Metabolic Research - 2011 -
Atropine improves insulin sensitivity in both lean and abdominally obese
subjects.
M.K Svensson, Per-Anders Jansson, A L Persson, M Sjöstrand, Jan W Eriksson
The Journal of clinical endocrinology and metabolism - 2011 -
Tadalafil increases muscle capillary recruitment and forearm glucose uptake in women with type 2
diabetes
Per-Anders Jansson, G. Murdolo, Lovisa Sjögren, Britta Nyström, Mikaela Sjöstrand, Lena Strindberg, Peter Lönnroth
DIABETOLOGIA - 2010 -
The SNARE protein SNAP23 and the SNARE-interacting protein Munc18c in human skeletal muscle are implicated in insulin resistance/type 2
diabetes.
Pontus Boström, Linda Andersson, Birgitte Vind, Liliana Håversen, Mikael Rutberg, Ylva Wickström, Erik Larsson, Per-Anders Jansson, M.K Svensson, Rickard Brånemark, Charlotte Ling, Henning Beck-Nielsen, Jan Borén, Kurt Højlund, Sven-Olof Olofsson
Diabetes - 2010 -
Repeated measurements of 11β-HSD-1 activity in subcutaneous adipose tissue from lean, abdominally obese, and type 2 diabetes subjects--no change following a mixed
meal.
M Sjöstrand, Per-Anders Jansson, Jenny Palming, J de Schoolmeester, D Gill, A Rees, Lovisa Sjögren, T Persson, Jan W Eriksson
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et métabolisme - 2010 -
The response to: Distinct metabolic effects of different classes of antihypertensive
drugs.
Jan W Eriksson, Per-Anders Jansson
Hypertension - 2009 -
Increased MAPK activation and impaired insulin signaling in subcutaneous microvascular endothelial cells in type 2 diabetes: the role of
endothelin-1
Silvia Gogg, Ulf Smith, Per-Anders Jansson
Diabetes - 2009 -
Variant near ADAMTS9 known to associate with type 2 diabetes is related to insulin resistance in offspring of type 2 diabetes patients--EUGENE2
study
T. W. Boesgaard, A. P. Gjesing, N. Grarup, J. Rutanen, Per-Anders Jansson, M. L. Hribal, G. Sesti, A. Fritsche, N. Stefan, H. Staiger, H. Haring, Ulf Smith, M. Laakso, O. Pedersen, T. Hansen
PLoS One - 2009 -
Acute hyperinsulinemia differentially regulates interstitial and circulating adiponectin oligomeric pattern in lean and insulin-resistant, obese
individuals
Giuseppe Murdolo, Ann Hammarstedt, M. Schmelz, Per-Anders Jansson, Ulf Smith
J Clin Endocrinol Metab - 2009 -
Hydrochlorothiazide, but not Candesartan, aggravates insulin resistance and causes visceral and hepatic fat accumulation: the mechanisms for the diabetes preventing effect of Candesartan (MEDICA)
study
Jan W Eriksson, Per-Anders Jansson, B Carlberg, A Hägg, L Kurland, Maria Svensson, H Ahlström, C Sröm, Lars Lönn, K. Ojbrandt, L Johansson, Lars Lind
Hypertension - 2008 -
Effects of intrabrachial metacholine infusion on muscle capillary recruitment and forearm glucose uptake during physiological hyperinsulinemia in obese, insulin-resistant
individuals
Giuseppe Murdolo, Mikaela Sjöstrand, Lena Strindberg, Soffia Gudbjörnsdottir, Lars Lind, Peter Lönnroth, Per-Anders Jansson
Journal of Clinical Endocrinology and Metabolism - 2008 -
Single-nucleotide polymorphism rs7754840 of CDKAL1 is associated with impaired insulin secretion in nondiabetic offspring of type 2 diabetic subjects and in a large sample of men with normal glucose
tolerance
A. Stancakova, J. Pihlajamaki, J. Kuusisto, N. Stefan, A. Fritsche, H. Haring, F. Andreozzi, E. Succurro, G. Sesti, T. W. Boesgaard, T. Hansen, O. Pedersen, Per-Anders Jansson, Ann Hammarstedt, Ulf Smith, M. Laakso
Journal of Clinical Endocrinology & Metabolism - 2008 -
In situ profiling of adipokines in subcutaneous microdialysates from lean and obese
individuals
Giuseppe Murdolo, Christian Herder, Zhaohui Wang, Bettina Rose, Martin Schmelz, Per-Anders Jansson
American Journal of Physiology-Endocrinology and Metabolism - 2008 -
The common SLC30A8 Arg325Trp variant is associated with reduced first-phase insulin release in 846 non-diabetic offspring of type 2 diabetes patients--the EUGENE2
study
T. W. Boesgaard, J. Zilinskaite, M. Vanttinen, M. Laakso, Per-Anders Jansson, Ann Hammarstedt, Ulf Smith, N. Stefan, A. Fritsche, H. Haring, M. Hribal, G. Sesti, D. P. Zobel, O. Pedersen, T. Hansen
Diabetologia - 2008 -
A candidate type 2 diabetes polymorphism near the HHEX locus affects acute glucose-stimulated insulin release in European populations: results from the EUGENE2
study
H. Staiger, A. Stancakova, J. Zilinskaite, M. Vanttinen, T. Hansen, M. A. Marini, Ann Hammarstedt, Per-Anders Jansson, G. Sesti, Ulf Smith, O. Pedersen, M. Laakso, N. Stefan, A. Fritsche, H. U. Haring
Diabetes - 2008 -
Insulin sensitivity, insulin release and glucagon-like peptide-1 levels in persons with impaired fasting glucose and/or impaired glucose tolerance in the EUGENE2
study
M. Laakso, J. Zilinskaite, T. Hansen, T. W. Boesgaard, M. Vanttinen, A. Stancakova, Per-Anders Jansson, F. Pellme, J. J. Holst, T. Kuulasmaa, M. L. Hribal, G. Sesti, N. Stefan, A. Fritsche, H. Haring, O. Pedersen, Ulf Smith
Diabetologia - 2008 -
Insulin differentially modulates the peripheral endocannabinoid system in human subcutaneous abdominal adipose tissue from lean and obese
individuals.
Giuseppe Murdolo, K Kempf, Ann Hammarstedt, C. Herder, Ulf Smith, Per-Anders Jansson
Journal of endocrinological investigation - 2007 -
Endothelial dysfunction in insulin resistance and type 2
diabetes.
Per-Anders Jansson
Journal of internal medicine - 2007 -
Monocyte chemoattractant protein-1 in subcutaneous abdominal adipose tissue: characterization of interstitial concentration and regulation of gene expression by
insulin
Giuseppe Murdolo, Ann Hammarstedt, Madelene Sandqvist, M. Schmelz, C. Herder, Ulf Smith, Per-Anders Jansson
J Clin Endocrinol Metab - 2007 -
Influence of central inhibition of sympathetic nervous activity on myocardial metabolism in chronic heart failure: acute effects of the imidazoline I1-receptor agonist
moxonidine.
Reza Mobini, Michael Fu, Per-Anders Jansson, Claes-Håkan Bergh, Margareta Scharin Täng, Finn Waagstein, Bert Andersson
Clinical science (London, England : 1979) - 2006 -
Postprandial interstitial insulin concentrations in type 2 diabetes
relatives
Madelene Sandqvist, Else Hellebö Johanson, B. Ahren, Mette Axelsen, M. Schmelz, Ulf Smith, Per-Anders Jansson
Eur J Clin Invest - 2006 -
Retinol-binding protein 4 and insulin resistance in lean, obese, and diabetic
subjects
T. E. Graham, Q. Yang, M. Bluher, Ann Hammarstedt, T. P. Ciaraldi, R. R. Henry, C. J. Wason, A. Oberbach, Per-Anders Jansson, Ulf Smith, B. B. Kahn
N Engl J Med - 2006 -
Visfatin is an adipokine, but it is not regulated by
thiazolidinediones
Ann Hammarstedt, J. Pihlajamaki, Victoria Rotter Sopasakis, Silvia Gogg, Per-Anders Jansson, M. Laakso, Ulf Smith
J Clin Endocrinol Metab - 2006 -
Low adipocyte IRS-1 protein expression is associated with an increased arterial stiffness in non-diabetic
males
Madelene Sandqvist, Gunnar Nyberg, Ann Hammarstedt, Natalia Klintland, Silvia Gogg, Kenneth Caidahl, Bo Ahrén, Ulf Smith, Per-Anders Jansson
Atherosclerosis - 2005 -
Sertoli-Leydig cell tumour in a postmenopausal woman showing all facets of the insulin resistance syndrome
(IRS)
Eva Dahlgren, Berit Gull, Roger Willen, F Sundler, T Rosen, Per-Anders Jansson
Ups J Med Sci - 2005 -
Long-term (1- and 2-year) effects of lifestyle intervention in type 2 diabetes
relatives.
Hilde Kristin Brekke, Per-Anders Jansson, Ragnhild Arvidsson Lenner
Diabetes research and clinical practice - 2005 -
Lifestyle modification improves risk factors in type 2 diabetes
relatives.
Hilde Kristin Brekke, Ragnhild Arvidsson Lenner, M. R. Taskinen, Jan-Eric Månsson, Tohru Funahashi, Yuji Matsuzawa, Per-Anders Jansson
Diabetes research and clinical practice - 2005 -
Improved insulin sensitivity and adipose tissue dysregulation after short-term treatment with pioglitazone in non-diabetic, insulin-resistant
subjects
Ann Hammarstedt, Victoria Rotter Sopasakis, Silvia Gogg, Per-Anders Jansson, Ulf Smith
Diabetologia - 2005 -
Effect of the interleukin-6 (-174) g/c promoter polymorphism on adiponectin and insulin
sensitivity
Xiao Lin Yang, Per-Anders Jansson, F. Pellme, M. Laakso, Ulf Smith
Obes Res - 2005 -
No acute effect of nateglinide on postprandial lipid and lipoprotein responses in subjects at risk for type 2
diabetes
Else Hellebö Johanson, Per-Anders Jansson, Birgit Gustafson, Madelene Sandqvist, M. R. Taskinen, Ulf Smith, Mette Axelsen
Diabetes Metab Res Rev - 2005 -
Evidence of impaired adipogenesis in insulin
resistance
Xiao Lin Yang, Per-Anders Jansson, Ivan Nagaev, M. M. Jack, Eugénia Carvalho, Katharina Stibrant Sunnerhagen, M. C. Cam, S. W. Cushman, Ulf Smith
Biochem Biophys Res Commun - 2004 -
Early alterations in the postprandial VLDL1 apoB-100 and apoB-48 metabolism in men with strong heredity for type 2
diabetes
Else Hellebö Johanson, Per-Anders Jansson, Birgit Gustafson, Lars Lönn, Ulf Smith, M. R. Taskinen, Mette Axelsen
J Intern Med - 2004 -
High local concentrations and effects on differentiation implicate interleukin-6 as a paracrine
regulator
Victoria Rotter Sopasakis, Madelene Sandqvist, Birgit Gustafson, Ann Hammarstedt, M. Schmelz, Xiao Lin Yang, Per-Anders Jansson, Ulf Smith
Obes Res - 2004 -
Inhibition of dipeptidyl peptidase-4 reduces glycemia, sustains insulin levels, and reduces glucagon levels in type 2
diabetes
Bo Ahrén, Mona Landin-Olsson, Per-Anders Jansson, Maria Svensson, David Holmes, A Schweizer
J Clin Endocrinol Metab - 2004 -
Lifestyle changes can be achieved through counseling and follow-up in first-degree relatives of patients with type 2
diabetes.
Hilde Kristin Brekke, Per-Anders Jansson, Jan-Eric Månsson, Ragnhild A Lenner
Journal of the American Dietetic Association - 2003 -
Fat distribution, lipid accumulation in the liver, and exercise capacity do not explain the insulin resistance in healthy males with a family history for type 2
diabetes.
Else H Johanson, Per-Anders Jansson, Lars Lönn, Yuji Matsuzawa, Tohru Funahashi, Marja-Riitta Taskinen, Ulf Smith, Mette Axelsen
The Journal of clinical endocrinology and metabolism - 2003 -
Endocrine abnormalities in healthy first-degree relatives of type 2 diabetes patients--potential role of steroid hormones and leptin in the development of insulin
resistance.
Per-Anders Jansson, Björn Eliasson, S Lindmark, Jan W Eriksson
European journal of clinical investigation - 2002 -
Determination of Lewis FUT3 gene mutations by PCR using sequence-specific primers enables efficient genotyping of clinical
samples.
Ammi Grahn, A Elmgren, L Aberg, Lola Svensson, Per-Anders Jansson, Peter Lönnroth, Göran Larson
Human mutation - 2001 -
Nicotine infusion acutely impairs insulin sensitivity in type 2 diabetic patients but not in healthy
subjects
T. Axelsson, Per-Anders Jansson, Ulf Smith, Björn Eliasson
J Intern Med - 2001 -
Insulin signaling and action in fat cells: associations with insulin resistance and type 2
diabetes.
Ulf Smith, Mette Axelsen, Eugénia Carvalho, Björn Eliasson, Per-Anders Jansson, Christian Wesslau
Annals of the New York Academy of Sciences - 1999 -
Postprandial hypertriglyceridemia and insulin resistance in normoglycemic first-degree relatives of patients with type 2
diabetes.
Mette Axelsen, Ulf Smith, Jan W Eriksson, M R Taskinen, Per-Anders Jansson
Annals of internal medicine - 1999 -
Low cellular IRS 1 gene and protein expression predict insulin resistance and
NIDDM.
Eugénia Carvalho, Per-Anders Jansson, Mette Axelsen, Jan Erik Eriksson, X Huang, L Groop, Cristina Rondinone, Lars Sjöström, Ulf Smith
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1999