Anna Rudin
About Anna Rudin
Professor in Inflammation Research, Deputy Head of the Institute of Medicine. Anna has a combined position at the Sahlgrenska University Hospital as university senior consultant in rheumatology. As representative for the Sahlgrenska Academy she is member of the management group at Sahlgrenska University Hospital.
Research
Anna conducts both clinical and translational research on rheumatoid arthritis, focusing on immunological causes of disease development and expression, as well as biomarkers for treatment effect. The material for this research derives from an investigator-initiated Nordic multicenter randomized four-armed treatment study NORD-STAR with 800 included patients, as well as from our local SYN-BIO study where we collect ultra-sound guided synovial biopsies from inflamed joints, synovial fluid and blood, including from controls without inflammatory disease.
Anna has started a specialized outpatient clinic for patients with rheumatologic adverse events from treatment with immune checkpoint inhibitors for cancer, and follows these patients in an observational study. In the group with malignant melanoma she investigates if markers on T-cells may associated to rheumatologic adverse events and effect of treatment of these.
She has also initiated a Swedish multicenter prospective observational study of pregnancy in patients with systemic lupus erythematosus and the association of immunological factors to complications during pregnancy. Previously she has performed research on immunological factors associated to development of allergic disease in a prospective birth cohort followed up to eight years of age, and has access to immunological and clinical data as well as data on bacterial colonization of the gut, including a biobank with plasma and cells.
Supervision
- Previous main supervisor of seven graduated PhD students and four post docs
- Present main supervisor of one PhD student, co-supervisor of four PhD students and main supervisor of one post doc
Biography
- MD University of Gothenburg 1985
- Licensed physician 1990
- PhD in microbiology and immunology University of Gothenburg 1996
- Post doc at Telethon Institute of Child Health research, Perth, Australia 1999
- Associate professor in immunology 2001
- Consultant in rheumatology 2009
- Adjunct professor in inflammation research 2010
- Senior consultant in rheumatology 2014
- Professor in inflammation research University of Gothenburg 2014
- University senior consultant in rheumatology Sahlgrenska University Hospital 2019
-
Active conventional treatment and three different biological treatments in early rheumatoid arthritis: phase IV investigator initiated, randomised, observer blinded clinical
trial
M. L. Hetland, E. A. Haavardsholm, Anna Rudin, D. Nordstrom, M. Nurmohamed, B. Gudbjornsson, J. Lampa, K. Horslev-Petersen, T. Uhlig, G. Grondal, M. Ostergaard, M. S. Heiberg, J. Twisk, K. Lend, S. Krabbe, L. H. Hyldstrup, J. Lindqvist, Anna-Karin H Ekwall, K. L. Gron, M. Kapetanovic, F. Faustini, R. Tuompo, T. Lorenzen, G. Cagnotto, E. Baecklund, O. Hendricks, D. Vedder, T. Sokka-Isler, T. Husmark, M. K. A. Ljosa, E. Brodin, T. Ellingsen, A. Soderbergh, M. Rizk, A. R. Olsson, P. Larsson, L. Uhrenholt, S. A. Just, D. J. Stevens, T. B. Laurberg, G. Bakland, I. C. Olsen, R. van Vollenhoven, Nord Star Study Grp Nord Star Study Grp
Bmj-British Medical Journal - 2020-01-01 -
Neonatal gut colonization by Bifidobacterium is associated with higher childhood cytokine
responses.
Hardis Rabe, Anna-Carin Lundell, Fei Sjöberg, Annika Ljung, Anna Strömbeck, Monica Gio-Batta, Cristina Maglio, Inger Nordström, Kerstin Andersson, Intawat Nookaew, Agnes E Wold, Ingegerd Adlerberth, Anna Rudin
Gut microbes - 2020-01-01 -
T helper cells in synovial fluid of patients with rheumatoid arthritis primarily have a Th1 and a CXCR3(+)Th2
phenotype
Jonathan Aldridge, Anna-Karin H Ekwall, Linda Mark, Beatrice Bergström, Kerstin Andersson, Inger Gjertsson, Anna-Carin Lundell, Anna Rudin
Arthritis Research & Therapy - 2020-01-01 -
Elevated adiponectin predicts the development of rheumatoid arthritis in subjects with
obesity
Y Zhang, M. Peltonen, Johanna C. Andersson-Assarsson, Per-Arne Svensson, C. Herder, Anna Rudin, Lena M S Carlsson, Cristina Maglio
Scandinavian Journal of Rheumatology - 2020-01-01 -
Anti-EF-Tu IgG titers increase with age and may contribute to protection against the respiratory pathogen Haemophilus
influenzae.
Oskar Thofte, Ravinder Kaur, Yu-Ching Su, Marta Brant, Anna Rudin, Derek Hood, Kristian Riesbeck
European journal of immunology - 2019-01-01 -
Patterns and predictors of skin score change in early diffuse systemic sclerosis from the European Scleroderma Observational
Study
A. L. Herrick, S. Peytrignet, M. Lunt, X. Pan, R. Hesselstrand, L. Mouthon, A. J. Silman, G. Dinsdale, E. Brown, L. Czirják, J. H. W. Distler, O. Distler, K. Fligelstone, W. J. Gregory, R. Ochiel, M. C. Vonk, C. Ancu, V. H. Ong, D. Farge, M. Hudson, M. Matucci-Cerinic, A. Balbir-Gurman, O. Midtvedt, P. Jobanputra, A. C. Jordan, W. Stevens, P. Moinzadeh, F. C. Hall, C. Agard, M. E. Anderson, E. Diot, R. Madhok, M. Akil, M. H. Buch, L. Chung, N. S. Damjanov, H. Gunawardena, P. Lanyon, Y. Ahmad, K. Chakravarty, S. Jacobsen, A. J. MacGregor, N. McHugh, U. Müller-Ladner, G. Riemekasten, M. Becker, J. Roddy, P. E. Carreira, A. L. Fauchais, E. Hachulla, J. Hamilton, M. Inanç, J. S. McLaren, J. M. Van Laar, S. Pathare, S. M. Proudman, Anna Rudin, J. Sahhar, B. Coppere, C. Serratrice, T. Sheeran, D. J. Veale, C. Grange, G. S. Trad, C. P. Denton
Annals of the Rheumatic Diseases - 2018-01-01 -
Sex-based differences in association between circulating T cell subsets and disease activity in untreated early rheumatoid arthritis
patients
Jonathan Aldridge, Jayesh M. Pandya, Linda Meurs, Kerstin Andersson, Inger Nordström, Elke Theander, Anna-Carin Lundell, Anna Rudin
Arthritis Research & Therapy - 2018-01-01 -
Pet-keeping in early life reduces the risk of allergy in a dose-dependent
fashion.
Bill Hesselmar, Anna Hicke-Roberts, Anna-Carin Lundell, Ingegerd Adlerberth, Anna Rudin, Robert Saalman, Göran Wennergren, Agnes E Wold
PloS one - 2018-01-01 -
Disability, fatigue, pain and their associates in early diffuse cutaneous systemic sclerosis: the European Scleroderma Observational
Study.
Sébastien Peytrignet, Christopher P Denton, Mark Lunt, Roger Hesselstrand, Luc Mouthon, Alan Silman, Xiaoyan Pan, Edith Brown, László Czirják, Jörg H W Distler, Oliver Distler, Kim Fligelstone, William J Gregory, Rachel Ochiel, Madelon Vonk, Codrina Ancuta, Voon H Ong, Dominique Farge, Marie Hudson, Marco Matucci-Cerinic, Alexandra Balbir-Gurman, Øyvind Midtvedt, Alison C Jordan, Wendy Stevens, Pia Moinzadeh, Frances C Hall, Christian Agard, Marina E Anderson, Elisabeth Diot, Rajan Madhok, Mohammed Akil, Maya H Buch, Lorinda Chung, Nemanja Damjanov, Harsha Gunawardena, Peter Lanyon, Yasmeen Ahmad, Kuntal Chakravarty, Søren Jacobsen, Alexander J MacGregor, Neil McHugh, Ulf Müller-Ladner, Gabriela Riemekasten, Michael Becker, Janet Roddy, Patricia E Carreira, Anne Laure Fauchais, Eric Hachulla, Jennifer Hamilton, Murat Inanç, John S McLaren, Jacob M van Laar, Sanjay Pathare, Susanna Proudman, Anna Rudin, Joanne Sahhar, Christine Serratrice, Tom Sheeran, Douglas J Veale, Claire Grange, Georges-Selim Trad, Ariane L Herrick
Rheumatology (Oxford, England) - 2018-01-01 -
Allergic disease in 8-year old children is preceded by delayed B-cell
maturation.
Anna Strömbeck, Inger Nordström, Kerstin Andersson, Helen Andersson, Susanne Johansen, Cristina Maglio, Hardis Rabe, Ingegerd Adlerberth, Agnes E Wold, Bill Hesselmar, Anna Rudin, Anna-Carin Lundell
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology - 2017-01-01 -
Effects of bariatric surgery on gout incidence in the Swedish Obese Subjects study: a non-randomised, prospective, controlled intervention
trial.
Cristina Maglio, Markku Peltonen, Martin Neovius, Peter Jacobson, Lennart T. H. Jacobsson, Anna Rudin, Lena M S Carlsson
Annals of the rheumatic diseases - 2017-01-01 -
Dihydrotestosterone levels at birth associate positively with higher proportions of circulating immature/naïve CD5+ B cells in
boys.
Anna-Carin Lundell, Inger Nordström, Kerstin Andersson, Anna Strömbeck, Claes Ohlsson, Åsa Tivesten, Anna Rudin
Scientific reports - 2017-01-01 -
Blood chemokine profile in untreated early rheumatoid arthritis: CXCL10 as a disease activity
marker
Jayesh M. Pandya, Anna-Carin Lundell, Kerstin Andersson, Inger Nordström, Elke Theander, Anna Rudin
Arthritis Research and Therapy - 2017-01-01 -
Umbilical Cord Blood Androgen Levels in Girls and Boys Assessed by Gas Chromatography-Tandem Mass
Spectrometry.
Anna-Carin Lundell, Henrik Ryberg, Liesbeth Vandenput, Anna Rudin, Claes Ohlsson, Åsa Tivesten
The Journal of steroid biochemistry and molecular biology - 2017-01-01 -
Bariatric Surgery and the Incidence of Psoriasis and Psoriatic Arthritis in the Swedish Obese Subjects
Study.
Cristina Maglio, Markku Peltonen, Anna Rudin, Lena M S Carlsson
Obesity - 2017-01-01 -
Head-to-head comparison of aggressive conventional therapy and three biological treatments and comparison of two de-escalation strategies in patients who respond to treatment: Study protocol for a multicenter, randomized, open-label, blinded-assessor, phase 4
study
D. Glinatsi, M. S. Heiberg, Anna Rudin, D. Nordström, E. A. Haavardsholm, B. Gudbjornsson, M. Østergaard, T. Uhlig, G. Grondal, K. Hørslev-Petersen, R. van Vollenhoven, M. L. Hetland
Trials - 2017-01-01 -
Methotrexate reduces vaccine-specific immunoglobulin levels but not numbers of circulating antibody-producing B cells in rheumatoid arthritis after vaccination with a conjugate pneumococcal
vaccine.
Meliha C Kapetanovic, Johanna Nagel, Inger Nordström, Tore Saxne, Pierre Geborek, Anna Rudin
Vaccine - 2017-01-01 -
Treatment outcome in early diffuse cutaneous systemic sclerosis: the European Scleroderma Observational Study
(ESOS).
Ariane L Herrick, Xiaoyan Pan, Sébastien Peytrignet, Mark Lunt, Roger Hesselstrand, Luc Mouthon, Alan Silman, Edith Brown, László Czirják, Jörg H W Distler, Oliver Distler, Kim Fligelstone, William J Gregory, Rachel Ochiel, Madelon Vonk, Codrina Ancuţa, Voon H Ong, Dominique Farge, Marie Hudson, Marco Matucci-Cerinic, Alexandra Balbir-Gurman, Øyvind Midtvedt, Alison C Jordan, Paresh Jobanputra, Wendy Stevens, Pia Moinzadeh, Frances C Hall, Christian Agard, Marina E Anderson, Elisabeth Diot, Rajan Madhok, Mohammed Akil, Maya H Buch, Lorinda Chung, Nemanja Damjanov, Harsha Gunawardena, Peter Lanyon, Yasmeen Ahmad, Kuntal Chakravarty, Søren Jacobsen, Alexander J MacGregor, Neil McHugh, Ulf Müller-Ladner, Gabriela Riemekasten, Michael Becker, Janet Roddy, Patricia E Carreira, Anne Laure Fauchais, Eric Hachulla, Jennifer Hamilton, Murat İnanç, John S McLaren, Jacob M van Laar, Sanjay Pathare, Susannah Proudman, Anna Rudin, Joanne Sahhar, Brigitte Coppere, Christine Serratrice, Tom Sheeran, Douglas J Veale, Claire Grange, Georges-Selim Trad, Christopher P Denton
Annals of the rheumatic diseases - 2017-01-01 -
IFN type I and II induce BAFF secretion from human decidual stromal
cells
Anna-Carin Lundell, Inger Nordström, Kerstin Andersson, Christina Lundqvist, Esbjörn Telemo, S. Nava, H. Kaipe, Anna Rudin
Scientific Reports - 2017-01-01 -
Circulating T helper and T regulatory subsets in untreated early rheumatoid arthritis and healthy control
subjects
Jayesh M. Pandya, Anna-Carin Lundell, Magnus Hallström, Kerstin Andersson, Inger Nordström, Anna Rudin
Journal of Leukocyte Biology - 2016-01-01 -
Earlier infantile immune maturation is related to higher DTP vaccine responses in
children
Anna Strömbeck, Anna-Carin Lundell, Inger Nordström, Kerstin Andersson, Ingegerd Adlerberth, Agnes E Wold, Anna Rudin
Clinical & Translational Immunology - 2016-01-01 -
Delayed adaptive immunity is related to higher MMR vaccine-induced antibody titers in
children
Anna Strömbeck, Anna-Carin Lundell, Inger Nordström, Kerstin Andersson, Ingegerd Adlerberth, Agnes E Wold, Anna Rudin
Clinical & Translational Immunology - 2016-01-01 -
Higher B-cell activating factor levels at birth are positively associated with maternal dairy farm exposure and negatively related to allergy
development
Anna-Carin Lundell, Bill Hesselmar, Inger Nordström, Ingegerd Adlerberth, Agnes E Wold, Anna Rudin
Journal of Allergy and Clinical Immunology - 2015-01-01 -
High Proportion of CD5(+) B Cells in Infants Predicts Development of Allergic
Disease
Anna-Carin Lundell, S. Johansen, Ingegerd Adlerberth, Agnes E Wold, Bill Hesselmar, Anna Rudin
Journal of Immunology - 2014-01-01 -
High proportions of FOXP3(+) CD25(high) T cells in neonates are positively associated with allergic sensitization later in
childhood.
Anna Strömbeck, Hardis Rabe, Anna-Carin Lundell, Kerstin Andersson, Susanne Johansen, Ingegerd Adlerberth, Agnes E Wold, Bill Hesselmar, Anna Rudin
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology - 2014-01-01 -
Staphylococcus aureus convert neonatal conventional CD4(+) T cells into FOXP3(+) CD25(+) CD127(low) T cells via the PD-1/PD-L1
axis
Hardis Rabe, Inger Nordström, Kerstin Andersson, Anna-Carin Lundell, Anna Rudin
Immunology - 2014-01-01 -
Cord blood neutrophils display a galectin-3 responsive phenotype accentuated by vaginal
delivery.
Martina Sundqvist, Veronica Osla, Bo Jacobsson, Anna Rudin, Karin Sävman, Anna Karlsson
BMC pediatrics - 2013-01-01 -
Infant B cell memory and gut bacterial
colonization
Anna Rudin, Anna-Carin Lundell
Gut microbes - 2012-01-01 -
Enveloped virus but not bacteria block IL-13 responses in human cord blood T cells in
vitro.
Alexandra Svensson, Inger Nordström, Anna Rudin, Tomas Bergström, Kristina Eriksson
Scandinavian journal of immunology - 2012-01-01 -
Infant B cell memory differentiation and early gut bacterial
colonization.
Anna-Carin Lundell, Viktor Björnsson, Annika Ljung, Margareta Ceder, Susanne Johansen, Gunhild Lindhagen, Carl-Johan Törnhage, Ingegerd Adlerberth, Agnes E Wold, Anna Rudin
Journal of immunology (Baltimore, Md. : 1950) - 2012-01-01 -
Higher proportions of circulating FOXP3+ and CTLA-4+ regulatory T cells are associated with lower fractions of memory CD4+ T cells in
infants.
Hardis Rabe, Anna-Carin Lundell, Kerstin Andersson, Ingegerd Adlerberth, Agnes E Wold, Anna Rudin
Journal of leukocyte biology - 2011-01-01 -
Development of gut-homing receptors on circulating B cells during
infancy.
Anna-Carin Andersson Lundell, Hardis Rabe, Marianne Quiding-Järbrink, Kerstin Andersson, Inger Nordström, Ingegerd Adlerberth, Agnes E Wold, Anna Rudin
Clinical immunology - 2011-01-01 -
Infection of infants with human herpesvirus type 6 may be associated with reduced allergic sensitization and T-helper type 2
development.
Inger Nordström, Anna Rudin, Ingegerd Adlerberth, Agnes E Wold, Robert Saalman, Bill Hesselmar, Nils Åberg, Jan-Åke Liljeqvist, Kristina Eriksson
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology - 2010-01-01 -
Early fish introduction is associated with less eczema, but not sensitization, in
infants.
Bill Hesselmar, Robert Saalman, Anna Rudin, Ingegerd Adlerberth, Agnes E Wold
Acta paediatrica (Oslo, Norway : 1992) - 2010-01-01 -
Superantigenic Staphylococcus aureus stimulate production of IL-17 from memory but not naive T
cells.
Ulrika Islander, Annica Andersson, Erika Lindberg, Ingegerd Adlerberth, Agnes E Wold, Anna Rudin
Infection and immunity - 2010-01-01 -
Clara cell protein 16 (CC16) serum levels in infants during respiratory syncytial virus
infection.
Sofi Johansson, Sigurdur Kristjánsson, Stefania P Bjarnarson, Göran Wennergren, Anna Rudin
Acta paediatrica (Oslo, Norway : 1992) - 2009-01-01 -
High circulating immunoglobulin A levels in infants are associated with intestinal toxigenic Staphylococcus aureus and a lower frequency of
eczema.
Anna-Carin Lundell, Bill Hesselmar, Inger Nordström, Robert Saalman, Helen Karlsson, Erika Lindberg, Nils Åberg, Ingegerd Adlerberth, Agnes E Wold, Anna Rudin
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology - 2009-01-01 -
Dynamic development of homing receptor expression and memory cell differentiation of infant CD4+CD25high regulatory T
cells.
Hanna Grindebacke, Hanna Stenstad, Marianne Quiding-Järbrink, Jesper Waldenström, Ingegerd Adlerberth, Agnes E Wold, Anna Rudin
Journal of immunology (Baltimore, Md. : 1950) - 2009-01-01 -
CC16 Inhibits the Migration of Eosinophils Towards the Formyl Peptide fMLF but not Towards
PGD(2).
Sofi Johansson, Kerstin Andersson, Göran Wennergren, Christine Wennerås, Anna Rudin
Inflammation - 2009-01-01 -
Specific Immunotherapy to Birch Allergen Does not Enhance Suppression of Th2 Cells by CD4(+)CD25 (+) Regulatory T Cells During Pollen
Season.
Hanna Grindebacke, Pia Larsson, Kajsa Wing, Sabina Rak, Anna Rudin
Journal of clinical immunology - 2009-01-01 -
Increased levels of circulating soluble CD14 but not CD83 in infants are associated with early intestinal colonization with Staphylococcus
aureus
Anna-Carin Lundell, Ingegerd Adlerberth, Erika Lindberg, Helen Karlsson, Sofia Ekberg, Nils Åberg, Robert Saalman, Barry Hock, A. Steinkasserer, Bill Hesselmar, Agnes E Wold, Anna Rudin
Clin Exp Allergy - 2007-01-01 -
Soluble CD14 and CD83 from human neonatal antigen-presenting cells are inducible by commensal bacteria and suppress allergen-induced human neonatal Th2
differentiation
Anna-Carin Lundell, Kerstin Andersson, Elisabet Josefsson, A. Steinkasserer, Anna Rudin
Infect Immun - 2007-01-01 -
Clara cell 16-kd protein downregulates T(H)2 differentiation of human naive neonatal T
cells
Sofi Johansson, Göran Wennergren, Nils Åberg, Anna Rudin
Journal of Allergy and Clinical Immunology - 2007-01-01 -
Functional CD4+CD25high regulatory T cells are enriched in the colonic mucosa of patients with active ulcerative colitis and increase with disease
activity.
Nathalie Holmén, Anna Lundgren, Samuel B Lundin, Ann-Marie Bergin, Anna Rudin, Henrik Sjövall, Lena Öhman
Inflammatory bowel diseases - 2006-01-01 -
Phase I evaluation of intranasal trivalent inactivated influenza vaccine with nontoxigenic Escherichia coli enterotoxin and novel biovector as mucosal adjuvants, using adult
volunteers
I. Stephenson, M. C. Zambon, Anna Rudin, A. Colegate, A. Podda, R. Bugarini, G. Del Giudice, A. Minutello, S. Bonnington, Jan Holmgren, K. H. Mills, K. G. Nicholson
J Virol - 2006-01-01 -
FOXP3 identifies regulatory CD25bright CD4+ T cells in rheumatic
joints
D. Cao, O. Borjesson, Pia Larsson, Anna Rudin, I. Gunnarsson, L. Klareskog, V. Malmstrom, C. Trollmo
Scand J Immunol - 2006-01-01 -
Mucosal FOXP3-expressing CD4+ CD25high regulatory T cells in Helicobacter pylori-infected
patients
Anna Lundgren, Erika Strömberg, Åsa Sjöling, Catharina Lindholm, Karin Enarsson, Anders Edebo, Erik Johnsson, Elisabeth Suri-Payer, Pia Larsson, Anna Rudin, Ann-Mari Svennerholm, Samuel B Lundin
Infect Immun - 2005-01-01 -
CD4+CD25+-regulatory T cells from mouse to
man
Kajsa Wing, Elisabeth Suri-Payer, Anna Rudin
Scand J Immunol - 2005-01-01 -
CD4+ CD25+ FOXP3+ regulatory T cells from human thymus and cord blood suppress antigen-specific T cell
responses
Kajsa Wing, Pia Larsson, Kerstin Sandström, Samuel B Lundin, Elisabeth Suri-Payer, Anna Rudin
Immunology - 2005-01-01 -
Cat allergen induces proinflammatory responses by human monocyte-derived macrophages but not by dendritic
cells
Anna-Carin Andersson Lundell, Hanna Grindebacke, Helen Karlsson, U. Seppala, Anna Rudin
Allergy - 2005-01-01 -
Cat allergen induces proinflammatory responses by human monocyte-derived macrophages but not by dendritic
cells
Anna-Carin Andersson Lundell, Hanna Grindebacke, Helen Karlsson, U Seppälä, Anna Rudin
Allergy - 2005-01-01 -
Pattern of cytokine responses to gram-positive and gram-negative commensal bacteria is profoundly changed when monocytes differentiate into dendritic
cells
Helen Karlsson, Pia Larsson, Agnes E Wold, Anna Rudin
Infect Immun - 2004-01-01 -
Allergen extracts directly mobilize and activate human
eosinophils
Lena Svensson, Anna Rudin, Christine Wennerås
Eur J Immunol - 2004-01-01 -
Defective suppression of Th2 cytokines by CD4CD25 regulatory T cells in birch allergics during birch pollen
season
Hanna Grindebacke, Kajsa Wing, Anna-Carin Andersson, Elisabeth Suri-Payer, Sabina Rak, Anna Rudin
Clin Exp Allergy - 2004-01-01 -
Activation of human neonatal monocyte-derived dendritic cells by lipopolysaccharide down-regulates birch allergen-induced Th2
differentiation
Anna-Carin Andersson, U. Seppala, Anna Rudin
Eur J Immunol - 2004-01-01 -
CD4 T cell activation by myelin oligodendrocyte glycoprotein is suppressed by adult but not cord blood CD25+ T
cells.
Kajsa Wing, Susanne Lindgren, Gittan Kollberg, Anna Lundgren, Robert A Harris, Anna Rudin, Samuel B Lundin, Elisabeth Suri-Payer
European journal of immunology - 2003-01-01