Karin Horkeby
Researcher
Department of Internal Medicine and ClinicalAbout Karin Horkeby
I defended my thesis 2019 at CBAR (Centre for Bone and Arthritis Research). I have a master of science in pharmacy from Gothenburg University.
I'm doing research in estrogen signaling pathways with a specific interest in membrane estrogen receptor alpha. I'm doing research on how membrane estrogen receptor alpha affects the estrogenic response in inflammatory bone loss, in order to find new targets for the treatment of both osteoporosis and rheumatoid arthritis.
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Transplantation of gut microbiota from old mice into young healthy mice reduces lean mass but not bone
mass
Lina Lawenius, C. Cowardin, Louise Grahnemo, Julia Scheffler, Karin Horkeby, Cecilia Engdahl, Jianyao Wu, Liesbeth Vandenput, A. Koskela, J. Tukkanen, E. Coward, K. Hveem, A. Langhammer, Sanna Abrahamsson, J. I. Gordon, Klara Sjögren, Claes Ohlsson
Gut Microbes - 2023 -
Bazedoxifene does not share estrogens effects on IgG
sialylation
Priti Gupta, Karin Horkeby, Hans Carlsten, Petra Henning, Cecilia Engdahl
Plos One - 2023 -
Dietary Progesterone Contributes to Intratissue Levels of Progesterone in Male
Mice
Hannah Colldén, Malin Hagberg Thulin, A. Landin, Karin Horkeby, Marie Lagerquist, Jianyao Wu, Karin H. Nilsson, Louise Grahnemo, Matti Poutanen, H. Ryberg, Liesbeth Vandenput, Claes Ohlsson
Endocrinology - 2023 -
A tissue-specific role of membrane-initiated ERα signaling for the effects of
SERMs
Karin L. Gustafsson, Sofia Movérare-Skrtic, Helen H. Farman, Cecilia Engdahl, Petra Henning, Karin H. Nilsson, Julia M. Scheffler, Edina Sehic, Ulrika Islander, E. Levin, Claes Ohlsson, Marie K Lagerquist
Journal of Endocrinology - 2022 -
Estradiol and RSPO3 regulate vertebral trabecular bone mass independent of each
other
Karin H. Nilsson, Jianyao Wu, Karin L. Gustafsson, Maha El Shahawy, A. Koskela, J. Tuukkanen, J. Tuckermann, Petra Henning, Ulf H Lerner, Claes Ohlsson, Sofia Movérare-Skrtic
American journal of physiology. Endocrinology and metabolism - 2022 -
Development of a synbiotic that protects against ovariectomy-induced trabecular bone
loss
Lina Lawenius, Karin L. Gustafsson, Jianyao Wu, Karin H. Nilsson, Sofia Moverare-Skrtic, E. M. Schott, M. J. Soto-Giron, G. V. Toledo, Klara Sjögren, Claes Ohlsson
American Journal of Physiology-Endocrinology and Metabolism - 2022 -
ER alpha Signaling in a Subset of CXCL12-Abundant Reticular Cells Regulates Trabecular Bone in
Mice
Julia M. Scheffler, Karin L. Gustafsson, Aidan Barrett, Carmen Corciulo, Christina Drevinge, Alicia M. del Carpio Pons, Piotr Humeniuk, Cecilia Engdahl, J. A. Gustafsson, Claes Ohlsson, Hans Carlsten, Marie K Lagerquist, Ulrika Islander
JBMR Plus - 2022 -
A tissue-selective estrogen complex as treatment of osteoporosis in experimental
lupus
Jauqueline Nordqvist, Cecilia Engdahl, Julia M. Scheffler, Priti Gupta, Karin L. Gustafsson, Marie K Lagerquist, Hans Carlsten, Ulrika Islander
Lupus - 2022 -
Comprehensive Sex Steroid Profiling in Multiple Tissues Reveals Novel Insights in Sex Steroid Distribution in Male
Mice
Hannah Colldén, Maria E. Nilsson, A. K. Norlen, A. Landin, S. H. Windahl, Jianyao Wu, Karin L. Gustafsson, Matti Poutanen, H. Ryberg, Liesbeth Vandenput, Claes Ohlsson
Endocrinology - 2022 -
Pulsed administration for physiological estrogen replacement in
mice
Carmen Corciulo, Julia M. Scheffler, Karin L. Gustafsson, Christina Drevinge, Piotr Humeniuk, Alicia M. del Carpio Pons, Matti Poutanen, Claes Ohlsson, Marie K Lagerquist, Ulrika Islander
F1000Research - 2021 -
RSPO3 is important for trabecular bone and fracture risk in mice and
humans
Karin H. Nilsson, Petra Henning, Maha El Shahawy, Maria Nethander, T. L. Andersen, C. Ejersted, Jianyao Wu, Karin L. Gustafsson, A. Koskela, J. Tuukkanen, P. P. C. Souza, J. Tuckermann, Mattias Lorentzon, Linda Engström-Ruud, T. Lehtimaki, J. H. Tobias, S. R. Zhou, Ulf H Lerner, J. B. Richards, Sofia Moverare-Skrtic, Claes Ohlsson
Nature Communications - 2021 -
Acute fat loss does not affect bone
mass
Marie K Lagerquist, Karin L. Gustafsson, Petra Henning, Helen H. Farman, Jianyao Wu, Klara Sjögren, A. Koskela, J. Tuukkanen, Claes Ohlsson, Ingrid Wernstedt Asterholm, Louise Grahnemo
Scientific Reports - 2021 -
Mild stimulatory effect of a probiotic mix on bone mass when treatment is initiated 1.5 weeks after ovariectomy in
mice
Claes Ohlsson, Lina Lawenius, Annica Andersson, Karin L. Gustafsson, Jianyao Wu, Marie Lagerquist, Sofia Moverare-Skrtic, Ulrika Islander, Klara Sjögren
American Journal of Physiology-Endocrinology and Metabolism - 2021 -
Arginine site 264 in murine estrogen receptor alpha is dispensable for the regulation of the
skeleton.
Karin L. Gustafsson, Helen H. Farman, Karin H. Nilsson, Petra Henning, Sofia Movérare-Skrtic, Vikte Lionikaite, Lina Lawenius, Cecilia Engdahl, Claes Ohlsson, Marie K Lagerquist
American journal of physiology. Endocrinology and metabolism - 2021 -
Pasteurized Akkermansia muciniphila protects from fat mass gain but not from bone
loss
Lina Lawenius, Julia M. Scheffler, Karin L. Gustafsson, Petra Henning, Karin H. Nilsson, Hannah Colldén, Ulrika Islander, H. Plovier, P. D. Cani, W. M. de Vos, Claes Ohlsson, Klara Sjögren
American Journal of Physiology-Endocrinology and Metabolism - 2020 -
The effects of estradiol are modulated in a tissue-specific manner in mice with inducible inactivation of ERα after sexual
maturation.
Claes Ohlsson, Helen H. Farman, Karin L. Gustafsson, Jianyao Wu, Petra Henning, Sara H Windahl, Klara Sjögren, Jan-Åke Gustafsson, Sofia Movérare-Skrtic, Marie Lagerquist
American journal of physiology. Endocrinology and metabolism - 2020 -
Interleukin 17A: a Janus-faced regulator of
osteoporosis
Julia M. Scheffler, Louise Grahnemo, Cecilia Engdahl, Christina Drevinge, Karin L. Gustafsson, Carmen Corciulo, Lina Lawenius, Y. Iwakura, Klara Sjögren, Marie Lagerquist, Hans Carlsten, Claes Ohlsson, Ulrika Islander
Scientific Reports - 2020 -
Phosphorylation site S122 in estrogen receptor α has a tissue-dependent role in female
mice
Claes Ohlsson, Karin L. Gustafsson, Helen H. Farman, Petra Henning, Vikte Lionikaite, Sofia Movérare-Skrtic, Klara Sjögren, Anna E Törnqvist, Annica Andersson, Ulrika Islander, Angelina I Bernardi, Matti Poutanen, Pierre Chambon, Marie K Lagerquist
FASEB Journal - 2020 -
Changes in mechanical loading affect arthritis-induced bone loss in
mice.
Anna-Maria Liphardt, Sara H Windahl, Edina Sehic, Nicole Hannemann, Karin L. Gustafsson, Aline Bozec, Georg Schett, Cecilia Engdahl
Bone - 2020 -
Increased bone mass in a mouse model with low fat
mass.
Louise Grahnemo, Karin L. Gustafsson, Klara Sjögren, Petra Henning, Vikte Lionikaite, Antti Koskela, Juha Tuukkanen, Claes Ohlsson, Ingrid Wernstedt Asterholm, Marie Lagerquist
American journal of physiology. Endocrinology and metabolism - 2018 -
Inducible Wnt16 inactivation: WNT16 regulates cortical bone thickness in adult
mice.
Claes Ohlsson, Petra Henning, Karin H. Nilsson, Jianyao Wu, Karin L. Gustafsson, Klara Sjögren, Anna E Törnqvist, Antti Koskela, Fu-Ping Zhang, Marie Lagerquist, Matti Poutanen, Juha Tuukkanen, Ulf H Lerner, Sofia Movérare-Skrtic
The Journal of endocrinology - 2018 -
Membrane estrogen receptor alpha is essential for estrogen signaling in the male
skeleton
Helen H. Farman, Karin L. Gustafsson, Petra Henning, Louise Grahnemo, Vikte Lionikaite, Sofia Moverare-Skrtic, Jianyao Wu, Henrik Ryberg, A. Koskela, J. Tuukkanen, E. R. Levin, Claes Ohlsson, Marie Lagerquist
Journal of Endocrinology - 2018 -
Clinically relevant doses of Vitamin A decrease cortical bone mass in
mice
Vikte Lionikaite, Karin L. Gustafsson, Anna Westerlund, Sara H Windahl, A. Koskela, J. Tuukkanen, H. Johansson, Claes Ohlsson, H. Herschel Conaway, Petra Henning, Ulf H Lerner
Journal of Endocrinology - 2018 -
WNT16 overexpression partly protects against glucocorticoid-induced bone
loss
Claes Ohlsson, Karin H. Nilsson, Petra Henning, Jianyao Wu, Karin L. Gustafsson, Matti Poutanen, Ulf H Lerner, Sofia Moverare-Skrtic
American Journal of Physiology-Endocrinology and Metabolism - 2018 -
ER alpha expression in T lymphocytes is dispensable for estrogenic effects in
bone
Karin L. Gustafsson, Karin H. Nilsson, Helen H. Farman, Vikte Lionikaite, Petra Henning, Jianyao Wu, Sara H Windahl, Ulrika Islander, Sofia Moverare-Skrtic, Klara Sjögren, Hans Carlsten, Claes Ohlsson, Marie Lagerquist
Journal of Endocrinology - 2018 -
Extra-nuclear effects of estrogen on cortical bone in males require
ERαAF-1
Helen H. Farman, Jianyao Wu, Karin L. Gustafsson, Sara H Windahl, S. H. Kim, J. A. Katzenellenbogen, Claes Ohlsson, Marie Lagerquist
Journal of Molecular Endocrinology - 2017 -
The role of membrane ER alpha signaling in bone and other major estrogen responsive
tissues
Karin L. Gustafsson, Helen H. Farman, Petra Henning, Vikte Lionikaite, Sofia Movérare-Skrtic, Jianyao Wu, Henrik Ryberg, A. Koskela, J. A. Gustafsson, J. Tuukkanen, E. R. Levin, Claes Ohlsson, Marie K Lagerquist
Scientific Reports - 2016 -
The bone-sparing effects of estrogen and WNT16 are independent of each
other
Sofia Movérare-Skrtic, Jianyao Wu, Petra Henning, Karin L. Gustafsson, Klara Sjögren, Sara H Windahl, A. Koskela, J. Tuukkanen, Anna E Börjesson, Marie K Lagerquist, Ulf H Lerner, F.P. Zhang, J.Å. Gustafsson, Matti Poutanen, Claes Ohlsson
Proceedings of the National Academy of Sciences of the United States of America - 2015