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Sture Lindegren
Forskare
Avd för medicinsk strålningsvetenskapOm Sture Lindegren
Docent/Radiokemist/Kliniska Vetenskaper/avdelningen för Medicinsk Strålningsvetenskap/Sahlgrenska Akademin vid Göteborgs Universitet
Arbetar med utveckling av radiofarmaka för behandling av spridd cancer.
Utvecklar nya metoder för att förbättra distribution av radiofarmaka
Har framställt en effektiv metod för att destillera och isolera astat-211 från bestrålad Vismut target och efterföljande metoder för syntes av astat-211 märkta antikroppar. Där ingår även utveckling av automatiska metoder för syntes av astat-211-radiofarmaka.
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Radiolabeling yield dependency of post-dry distillation decay of
astatine-211
Ellinor Hansson, Chiara Timperanza, Holger Jensen, Björn Eriksson, Sture Lindegren, Emma Aneheim
Nuclear Medicine and Biology - 2025 -
On-site activity determination of 211At using absolute 4pi-alpha liquid scintillation counting and
HPGe
Erik Leidermark, Emma Aneheim, Tom Bäck, Sture Lindegren, H. Jensen, C. Dulieu, X. Mougeot, L. Persson, B. Sabot, Stig Palm
APPLIED RADIATION AND ISOTOPES - 2025 -
An 211At-labeled Tetrazine for Pretargeted
Therapy
Matthias M. Herth, Lars Hvass, Christian B. M. Poulie, Marius Muller, Rocio Garcia-Vazquez, Tobias Gustavsson, Vladimir Shalgunov, Anne S. Clausen, Jesper T. Jorgensen, Ellinor Hansson, Holger Jensen, Emma Aneheim, Sture Lindegren, Andreas Kjaer, Umberto M. Battisti
JOURNAL OF MEDICINAL CHEMISTRY - 2025 -
A proposed production method for astatinated (At-211) Trastuzumab for use in a Phase I clinical
trial
Emma Aneheim, Tom Bäck, Holger Jensen, Stig Palm, Sture Lindegren
PLOS ONE - 2024 -
Modified poly-L-lysine for use as a clearing agent in pretargeted
radioimmunotherapy
Chiara Timperanza, Anna Gustafsson-Lutz, Tom Bäck, Damian J. Green, Sture Lindegren, Emma Aneheim
EJNMMI RADIOPHARMACY AND CHEMISTRY - 2024 -
Rapid Electrophilic 211At-Astatination of Trimethylgermyl
Arenes
Marius Mueller, Umberto Maria Battisti, Merlin Zabrocki, Ellinor Hansson, Holger Jensen, Emma Aneheim, Sture Lindegren, Matthias Manfred Herth
CHEMPLUSCHEM - 2024 -
In vitro and in vivo evaluation of a tetrazine-conjugated poly-L-lysine effector molecule labeled with
astatine-211
Chiara Timperanza, Holger Jensen, Ellinor Hansson, Tom Bäck, Sture Lindegren, Emma Aneheim
EJNMMI RADIOPHARMACY AND CHEMISTRY - 2024 -
Behaviour, use and safety aspects of astatine-211 solvated in chloroform after dry distillation
recovery
Emma Aneheim, Ellinor Hansson, Chiara Timperanza, Holger Jensen, Sture Lindegren
SCIENTIFIC REPORTS - 2024 -
A Novel Method for Real-Time Quantification of Radioligand Binding to Living Tumor Cells In
Vitro
Tom Bäck, Per Albertsson, Emma Aneheim, Ragnar Hultborn, Lars Jacobsson, Sture Lindegren, Stig Palm
CANCER BIOTHERAPY AND RADIOPHARMACEUTICALS - 2024 -
Astatine-211 based radionuclide therapy: Current clinical trial
landscape
Per Albertsson, Tom Bäck, Karin Bergmark, Andreas Hallqvist, Mia Johansson, Emma Aneheim, Sture Lindegren, Chiara Timperanza, K. Smerud, Stig Palm
Frontiers in Medicine - 2023 -
Improved syntheses of P2X(7) ligands based on substituted benzyl amide of pyroglutamic acid motif labelled with iodine-123 or
iodine-125
A. Maresova, M. Jurasek, T. Zimmermann, P. Drasar, M. Petrik, P. Dzubak, Sture Lindegren, P. Cumming, R. Pichler, A. Popkov
Journal of Radioanalytical and Nuclear Chemistry - 2023 -
Pretargeted Alpha Therapy of Disseminated Cancer Combining Click Chemistry and
Astatine-211
Chiara Timperanza, H. Jensen, Tom Bäck, Sture Lindegren, Emma Aneheim
Pharmaceuticals - 2023 -
Estimating the risk for secondary cancer following targeted alpha therapy with astatine-211 intraperitoneal
radioimmunotherapy.
Erik Leidermark, Andreas Hallqvist, Lars Jacobsson, Per Karlsson, Erik Holmberg, Tom Bäck, Mia Johansson, Sture Lindegren, Stig Palm, Per Albertsson
Journal of nuclear medicine : official publication, Society of Nuclear Medicine - 2022 -
Covalent core-radiolabeling of polymeric micelles with125I/211At for theranostic
radiotherapy
E. Sporer, C. B. M. Poulie, Tom Bäck, Sture Lindegren, H. Jensen, P. J. Kempen, A. Kjaer, M. M. Herth, A. I. Jensen
Nanotheranostics - 2022 -
Evaluation of therapeutic efficacy of 211At-labeled farletuzumab in an intraperitoneal mouse model of disseminated ovarian
cancer
Stig Palm, Tom Bäck, Emma Aneheim, Andreas Hallqvist, Ragnar Hultborn, Lars Jacobsson, H. Jensen, Sture Lindegren, Per Albertsson
Translational Oncology - 2021 -
Realizing Clinical Trials with Astatine-211: The Chemistry
Infrastructure
Sture Lindegren, Per Albertsson, Tom Bäck, H. Jensen, Stig Palm, Emma Aneheim
Cancer Biotherapy and Radiopharmaceuticals - 2020 -
Targeted alpha therapy with astatine-211-labeled anti-PSCA A11 minibody shows antitumor efficacy in prostate cancer xenografts and bone
microtumors
Tom Bäck, Karin Jennbacken, Malin Hagberg Thulin, Sture Lindegren, H. Jensen, T. Olafsen, P. J. Yazaki, Stig Palm, Per Albertsson, Jan-Erik Damber, A. M. Wu, Karin Welén
Ejnmmi Research - 2020 -
Labeling of Anti-HER2 Nanobodies with Astatine-211: Optimization and the Effect of Different Coupling Reagents on Their in Vivo
Behavior
Y. Dekempeneer, Tom Bäck, Emma Aneheim, H. Jensen, J. Puttemans, C. Xavier, M. Keyaerts, Stig Palm, Per Albertsson, T. Lahoutte, V. Caveliers, Sture Lindegren, M. D'Huyvetter
Molecular Pharmaceutics - 2019 -
Towards elucidating the radiochemistry of astatine - Behavior in
chloroform
Emma Aneheim, Stig Palm, H. Jensen, C. Ekberg, Per Albertsson, Sture Lindegren
Scientific Reports - 2019 -
Intraperitoneal alpha-Emitting Radioimmunotherapy with At-211 in Relapsed Ovarian Cancer: Long-Term Follow-up with Individual Absorbed Dose
Estimations
Andreas Hallqvist, Karin Bergmark, Tom Bäck, Håkan Andersson, Pernilla Dahm-Kähler, Mia Johansson, Sture Lindegren, H. Jensen, Lars Jacobsson, Ragnar Hultborn, Stig Palm, Per Albertsson
Journal of Nuclear Medicine - 2019 -
Astatine-211: The Chemistry
Infrastructure.
Sture Lindegren, Tom Bäck, Stig Palm, Holger Jensen, Per Albertsson, Emma Aneheim
Journal of Medical Imaging and Radiation Sciences - 2019 -
Intraperitoneal Alpha-emitting Radio Immunotherapy with Astatine-211 in Relapsed Ovarian Cancer; Long-term Follow-up with Individual Absorbed Dose
Estimations.
Andreas Hallqvist, Per Albertsson, Ragnar Hultborn, Stig Palm, Karin Bergmark, Tom Bäck, Håkan Andersson, Pernilla Dahm-Kähler, Mia Johansson, Sture Lindegren, Holger Jensen, Lars Jacobsson
Journal of Medical Imaging and Radiation Sciences - 2019 -
Estimation of Long-term Risks for Cancer Induction following Adjuvant Targeted Alpha Therapy with Curative
Intent.
Stig Palm, Andreas Hallqvist, Emma Aneheim, Tom Bäck, Mia Johansson, Ragnar Hultborn, Lars Jacobsson, Sture Lindegren, Per Albertsson
Journal of Medical Imaging and Radiation Sciences - 2019 -
Quantified Cell Binding of Astatinated Immunoconjugates onOvarian Cancer Cell Spheroids by Alpha Camera
Imaging.
Tom Bäck, M Verhoeven, Emma Aneheim, Per Albertsson, Stig Palm, Sture Lindegren, Holger Jensen
Journal of Medical Imaging and Radiation Sciences - 2019 -
Multifunctional Clickable Reagents for Rapid Bioorthogonal Astatination and
Radio-Crosslinking
C. Denk, M. Wilkovitsch, Emma Aneheim, M. M. Herth, H. Jensen, Sture Lindegren, H. Mikula
ChemPlusChem - 2019 -
Model of Intraperitoneal Targeted α-Particle Therapy Shows That Posttherapy Cold-Antibody Boost Enhances Microtumor Radiation Dose and Treatable Tumor
Sizes.
Stig Palm, Tom Bäck, Sture Lindegren, Ragnar Hultborn, Lars Jacobsson, Per Albertsson
Journal of nuclear medicine : official publication, Society of Nuclear Medicine - 2018 -
Cure of Human Ovarian Carcinoma Solid Xenografts by Fractionated alpha-Radioimmunotherapy with At-211-MX35-F(ab')(2): Influence of Absorbed Tumor Dose and Effect on Long-Term
Survival
Tom Bäck, N. Chouin, Sture Lindegren, Helena Kahu, H. Jensen, Per Albertsson, Stig Palm
Journal of Nuclear Medicine - 2017 -
Therapeutic efficacy of alpha-radioimmunotherapy with different activity levels of the Bi-213-labeled monoclonal antibody MX35 in an ovarian cancer
model
Anna Gustafsson-Lutz, Tom Bäck, Emma Aneheim, Ragnar Hultborn, Stig Palm, Lars Jacobsson, A. Morgenstern, F. Bruchertseifer, Per Albertsson, Sture Lindegren
EJNMMI Research - 2017 -
Biokinetic modeling and dosimetry for optimizing intraperitoneal radioimmunotherapy of ovarian cancer
microtumors.
Stig Palm, Tom Bäck, Börje Haraldsson, Lars Jacobsson, Sture Lindegren, Per Albertsson
Journal of nuclear medicine : official publication, Society of Nuclear Medicine - 2016 -
17AAG-induced internalisation of HER2-specific Affibody
molecules
L. Göstring, Sture Lindegren, L. Gedda
Oncology Letters - 2016 -
Synthesis and Evaluation of Astatinated N-[2-(Maleimido)ethyl]-3-(trimethylstannyl)benzamide
Immunoconjugates
Emma Aneheim, Anna Gustafsson, Per Albertsson, Tom Bäck, Holger Jensen, Stig Palm, Sofia Svedhem, Sture Lindegren
Bioconjugate chemistry - 2016 -
Absorbed Doses and Risk Estimates of (211)At-MX35 F(ab')2 in Intraperitoneal Therapy of Ovarian Cancer
Patients.
Elin Cederkrantz, Håkan Andersson, Peter Bernhardt, Thomas Backhaus, Ragnar Hultborn, Lars Jacobsson, Holger Jensen, Sture Lindegren, Michael Ljungberg, Tobias Magnander, Stig Palm, Per Albertsson
International journal of radiation oncology, biology, physics - 2015 -
Binding Affinity, Specificity and Comparative Biodistribution of the Parental Murine Monoclonal Antibody MX35 (Anti-NaPi2b) and Its Humanized Version
Rebmab200.
Sture Lindegren, Luciana N S Andrade, Tom Bäck, Camila Maria L Machado, Bruno Brasil Horta, Carlos Buchpiguel, Ana Maria Moro, Oswaldo Keith Okamoto, Lars Jacobsson, Elin Cederkrantz, Kohshin Washiyama, Emma Aneheim, Stig Palm, Holger Jensen, Maria Carolina B Tuma, Roger Chammas, Ragnar Hultborn, Per Albertsson
PloS one - 2015 -
N-[2-(maleimido)ethyl]-3-(trimethylstannyl)benzamide, a molecule for radiohalogenation of proteins and
peptides
Emma Aneheim, Mark Foreman, H. Jensen, Sture Lindegren
Applied Radiation and Isotopes - 2015 -
Automated astatination of biomolecules--a stepping stone towards multicenter clinical
trials.
Emma Aneheim, Per Albertsson, Tom Bäck, Holger Jensen, Stig Palm, Sture Lindegren
Scientific reports - 2015 -
Shelf-Life of e-Lysyl-3-(Trimethylstannyl)Benzamide Immunoconjugates, Precursors for At-211 Labeling of
Antibodies
Emma Aneheim, Jenny Halleröd, Per Albertsson, H. Jensen, Stellan Holgersson, Sture Lindegren
Cancer Biotherapy and Radiopharmaceuticals - 2015 -
Astatine-211 labeling: a study towards automatic production of astatinated
antibodies
Emma Aneheim, Holger Jensen, Per Albertsson, Sture Lindegren
Journal of Radioanalytical and Nuclear Chemistry - 2015 -
Modelling the biokinetics of intra-peritoneally administered targeted alpha therapy on patients for improved
dosimetry.
Stig Palm, Tom Bäck, Sture Lindegren, Holger Jensen, Per Albertsson, Lars Jacobsson
Journal of Nuclear Medicine - 2014 -
Effective dose of intraperitoneal α-radioimmunotherapy with
211At.
Elin Cederkrantz, Tom Bäck, Lars Jacobsson, Holger Jensen, Sture Lindegren, Stig Palm, Per Albertsson
Journal of Nuclear Medicine - 2014 -
Image-based small-scale 3D-dosimetry in targeted alpha therapy using voxel dose-point kernels and alpha camera imaging of serial tissue
sections.
Tom Bäck, Nicolas Chouin, Sture Lindegren, Holger Jensen, Per Albertsson, Stig Palm
Journal of Nuclear Medicine - 2014 -
Polylysine-based Effector Molecules and Clearing Agents for Pretargeting Systems in Therapy and Imaging – Increasing Avidity and Specific Activity and Providing Many Ways to Optimize In Vivo
Distribution.
Anna Gustafsson-Lutz, Tom Bäck, Per Albertsson, Stig Palm, A Morgenstern, F Bruchertseifer, Sture Lindegren
European Journal of Nuclear Medicine and Molecular Imaging - 2014 -
Intra-tumoral dose distributions after experimental targeted alpha therapy by Alpha-Camera
imaging.
Nicolas Chouin, Stig Palm, Sture Lindegren, Holger Jensen, Per Albertsson, Tom Bäck
European Journal of Nuclear Medicine and Molecular Imaging - 2014 -
Alpha particle induced DNA damage and repair in normal cultured thyrocytes of different proliferation
status.
Madeleine Nordén Lyckesvärd, Ulla Delle, Helena Kahu, Sture Lindegren, Holger Jensen, Tom Bäck, John Swanpalmer, Kerstin Elmroth
Mutation research. Fundamental and molecular mechanisms of mutagenesis - 2014 -
Sequential Radioimmunotherapy with (177)Lu- and (211)At-Labeled Monoclonal Antibody BR96 in a Syngeneic Rat Colon Carcinoma
Model.
Sophie E Eriksson, Erika Elgström, Tom Bäck, Tomas Ohlsson, Holger Jensen, Rune Nilsson, Sture Lindegren, Jan Tennvall
Cancer biotherapy & radiopharmaceuticals - 2014 -
A radio-high-performance liquid chromatography dual-flow cell gamma-detection system for on-line radiochemical purity and labeling efficiency
determination.
Sture Lindegren, Holger Jensen, Lars Jacobsson
Journal of chromatography. A - 2014 -
Ex Vivo Activity Quantification in Micrometastases at the Cellular Scale Using the α-Camera
Technique.
Nicolas Chouin, Sture Lindegren, Sofia Frost, Holger Jensen, Per Albertsson, Ragnar Hultborn, Stig Palm, Lars Jacobsson, Tom Bäck
Journal of nuclear medicine : official publication, Society of Nuclear Medicine - 2013 -
Comparison of (211)At-PRIT and (211)At-RIT of Ovarian Microtumors in a Nude Mouse
Model.
Sofia Frost, Tom Bäck, Nicolas Chouin, Ragnar Hultborn, Lars Jacobsson, Jörgen Elgqvist, Holger Jensen, Per Albertsson, Sture Lindegren
Cancer biotherapy & radiopharmaceuticals - 2013 -
Successful radioimmunotherapy of established syngeneic rat colon carcinoma with
211At-mAb.
Sophie E Eriksson, Tom Bäck, Erika Elgström, Holger Jensen, Rune Nilsson, Sture Lindegren, Jan Tennvall
EJNMMI research - 2013 -
Tumor Growth of Subcutaneous Xenografts after Repeated Alpha-Radioimmunotherapy with Astatine-211: What Absorbed Dose is Required to Treat Solid Tumors with Alpha-particle
Emitters?
Tom Bäck, Nicolas Chouin, Sture Lindegren, Holger Jensen, Stig Palm, Per Albertsson
European Journal of Nuclear Medicine and Molecular Imaging - 2012 -
Quantification of activity by alpha-camera imaging and small-scale dosimetry within ovarian carcinoma micrometastases treated with targeted alpha
therapy.
Nicolas Chouin, Sture Lindegren, Holger Jensen, Per Albertsson, Tom Bäck
Quarterly Journal of Nuclear Medicine and Molecular Imaging - 2012
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