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- Lars Jacobsson
Lars Jacobsson
Forskare
Avd för medicinsk-
A Novel Method for Real-Time Quantification of Radioligand Binding to Living Tumor Cells In
Vitro
Tom Bäck, Per Albertsson, Emma Aneheim, Ragnar Hultborn, Lars Jacobsson, Sture Lindegren, Stig Palm
CANCER BIOTHERAPY AND RADIOPHARMACEUTICALS - 2024 -
Evaluation of therapeutic efficacy of 211At-labeled farletuzumab in an intraperitoneal mouse model of disseminated ovarian
cancer
Stig Palm, Tom Bäck, Emma Aneheim, Andreas Hallqvist, Ragnar Hultborn, Lars Jacobsson, H. Jensen, Sture Lindegren, Per Albertsson
Translational Oncology - 2021 -
Intraperitoneal alpha-Emitting Radioimmunotherapy with At-211 in Relapsed Ovarian Cancer: Long-Term Follow-up with Individual Absorbed Dose
Estimations
Andreas Hallqvist, Karin Bergmark, Tom Bäck, Håkan Andersson, Pernilla Dahm-Kähler, Mia Johansson, Sture Lindegren, H. Jensen, Lars Jacobsson, Ragnar Hultborn, Stig Palm, Per Albertsson
Journal of Nuclear Medicine - 2019 -
Intraperitoneal Alpha-emitting Radio Immunotherapy with Astatine-211 in Relapsed Ovarian Cancer; Long-term Follow-up with Individual Absorbed Dose
Estimations.
Andreas Hallqvist, Per Albertsson, Ragnar Hultborn, Stig Palm, Karin Bergmark, Tom Bäck, Håkan Andersson, Pernilla Dahm-Kähler, Mia Johansson, Sture Lindegren, Holger Jensen, Lars Jacobsson
Journal of Medical Imaging and Radiation Sciences - 2019 -
Estimation of Long-term Risks for Cancer Induction following Adjuvant Targeted Alpha Therapy with Curative
Intent.
Stig Palm, Andreas Hallqvist, Emma Aneheim, Tom Bäck, Mia Johansson, Ragnar Hultborn, Lars Jacobsson, Sture Lindegren, Per Albertsson
Journal of Medical Imaging and Radiation Sciences - 2019 -
Model of Intraperitoneal Targeted α-Particle Therapy Shows That Posttherapy Cold-Antibody Boost Enhances Microtumor Radiation Dose and Treatable Tumor
Sizes.
Stig Palm, Tom Bäck, Sture Lindegren, Ragnar Hultborn, Lars Jacobsson, Per Albertsson
Journal of nuclear medicine : official publication, Society of Nuclear Medicine - 2018 -
Therapeutic efficacy of alpha-radioimmunotherapy with different activity levels of the Bi-213-labeled monoclonal antibody MX35 in an ovarian cancer
model
Anna Gustafsson-Lutz, Tom Bäck, Emma Aneheim, Ragnar Hultborn, Stig Palm, Lars Jacobsson, A. Morgenstern, F. Bruchertseifer, Per Albertsson, Sture Lindegren
EJNMMI Research - 2017 -
Biokinetic modeling and dosimetry for optimizing intraperitoneal radioimmunotherapy of ovarian cancer
microtumors.
Stig Palm, Tom Bäck, Börje Haraldsson, Lars Jacobsson, Sture Lindegren, Per Albertsson
Journal of nuclear medicine : official publication, Society of Nuclear Medicine - 2016 -
Absorbed Doses and Risk Estimates of (211)At-MX35 F(ab')2 in Intraperitoneal Therapy of Ovarian Cancer
Patients.
Elin Cederkrantz, Håkan Andersson, Peter Bernhardt, Thomas Backhaus, Ragnar Hultborn, Lars Jacobsson, Holger Jensen, Sture Lindegren, Michael Ljungberg, Tobias Magnander, Stig Palm, Per Albertsson
International journal of radiation oncology, biology, physics - 2015 -
Binding Affinity, Specificity and Comparative Biodistribution of the Parental Murine Monoclonal Antibody MX35 (Anti-NaPi2b) and Its Humanized Version
Rebmab200.
Sture Lindegren, Luciana N S Andrade, Tom Bäck, Camila Maria L Machado, Bruno Brasil Horta, Carlos Buchpiguel, Ana Maria Moro, Oswaldo Keith Okamoto, Lars Jacobsson, Elin Cederkrantz, Kohshin Washiyama, Emma Aneheim, Stig Palm, Holger Jensen, Maria Carolina B Tuma, Roger Chammas, Ragnar Hultborn, Per Albertsson
PloS one - 2015 -
Modelling the biokinetics of intra-peritoneally administered targeted alpha therapy on patients for improved
dosimetry.
Stig Palm, Tom Bäck, Sture Lindegren, Holger Jensen, Per Albertsson, Lars Jacobsson
Journal of Nuclear Medicine - 2014 -
Effective dose of intraperitoneal α-radioimmunotherapy with
211At.
Elin Cederkrantz, Tom Bäck, Lars Jacobsson, Holger Jensen, Sture Lindegren, Stig Palm, Per Albertsson
Journal of Nuclear Medicine - 2014 -
A radio-high-performance liquid chromatography dual-flow cell gamma-detection system for on-line radiochemical purity and labeling efficiency
determination.
Sture Lindegren, Holger Jensen, Lars Jacobsson
Journal of chromatography. A - 2014 -
Ex Vivo Activity Quantification in Micrometastases at the Cellular Scale Using the α-Camera
Technique.
Nicolas Chouin, Sture Lindegren, Sofia Frost, Holger Jensen, Per Albertsson, Ragnar Hultborn, Stig Palm, Lars Jacobsson, Tom Bäck
Journal of nuclear medicine : official publication, Society of Nuclear Medicine - 2013 -
Comparison of (211)At-PRIT and (211)At-RIT of Ovarian Microtumors in a Nude Mouse
Model.
Sofia Frost, Tom Bäck, Nicolas Chouin, Ragnar Hultborn, Lars Jacobsson, Jörgen Elgqvist, Holger Jensen, Per Albertsson, Sture Lindegren
Cancer biotherapy & radiopharmaceuticals - 2013 -
Comparison of therapeutic efficacy and biodistribution of (213)Bi- and (211)At-labeled monoclonal antibody MX35 in an ovarian cancer
model.
Anna Gustafsson, Tom Bäck, Jörgen Elgqvist, Lars Jacobsson, Ragnar Hultborn, Per Albertsson, Alfred Morgenstern, Frank Bruchertseifer, Holger Jensen, Sture Lindegren
Nuclear medicine and biology - 2012 -
Evaluation of Effects on the Peritoneum After Intraperitoneal α-Radioimmunotherapy with
(211)At.
Elin Cederkrantz, Eva Angenete, Tom Bäck, Peter Falk, Börje Haraldsson, Marie-Louise Ivarsson, Holger Jensen, Sture Lindegren, Ragnar Hultborn, Lars Jacobsson
Cancer biotherapy & radiopharmaceuticals - 2012 -
Patient-specific alpha-particle
dosimetry
Stig Palm, Jörgen Elgqvist, Lars Jacobsson
Current radiopharmaceuticals - 2011 -
Statistical and dosimetric analysis of the penetration of antibody fragments F(ab')2 radiolabeled with 211At within subcutaneous
tumors.
Nicolas Chouin, Tom Bäck, M Bardies, Sofia Frost, Sture Lindegren, Stig Palm, O Press, Lars Jacobsson
Journal of Nuclear Medicine - 2011 -
In Vivo Distribution of Avidin-Conjugated MX35 and (211)At-Labeled, Biotinylated Poly-l-Lysine for Pretargeted Intraperitoneal
?-Radioimmunotherapy.
Sofia Frost, Tom Bäck, Nicolas Chouin, Holger Jensen, Ragnar Hultborn, Lars Jacobsson, Sture Lindegren
Cancer biotherapy & radiopharmaceuticals - 2011 -
The alpha-camera: a quantitative digital autoradiography technique using a charge-coupled device for ex vivo high-resolution bioimaging of
alpha-particles.
Tom Bäck, Lars Jacobsson
Journal of nuclear medicine : official publication, Society of Nuclear Medicine - 2010 -
Intraperitoneal alpha-particle radioimmunotherapy of ovarian cancer patients: pharmacokinetics and dosimetry of (211)At-MX35 F(ab')2--a phase I
study.
Håkan Andersson, Elin Cederkrantz, Tom Bäck, Chaitanya Divgi, Jörgen Elgqvist, Jakob Himmelman, György Horvath, Lars Jacobsson, Holger Jensen, Sture Lindegren, Stig Palm, Ragnar Hultborn
Journal of nuclear medicine : official publication, Society of Nuclear Medicine - 2009 -
Glomerular filtration rate after alpha-radioimmunotherapy with 211At-MX35-F(ab')2: a long-term study of renal function in nude
mice.
Tom Bäck, Börje Haraldsson, Ragnar Hultborn, Holger Jensen, Martin E Johansson, Sture Lindegren, Lars Jacobsson
Cancer biotherapy & radiopharmaceuticals - 2009 -
Intraperitoneal alpha-radioimmunotherapy of ovarian cancer – pharmacokinetics and dosimetry of 211At-MX35 F(ab’)2 in a phase I
study.
E Haglund, Håkan Andersson, Tom Bäck, C Divgi, Jörgen Elgqvist, Sofia Frost, Jakob Himmelman, György Horvath, Ragnar Hultborn, Holger Jensen, Sture Lindegren, Stig Palm, Lars Jacobsson
Cancer Biotherapy and Radiopharmaceuticals - 2008 -
Intraperitoneal alpha-radioimmunotherapy of ovarian cancer – pharmacokinetics and dosimetry of 211At-MX35 F(ab’)2 in a phase I
study.
E Haglund, Håkan Andersson, Tom Bäck, C Divgi, Jörgen Elgqvist, Sofia Frost, Jakob Himmelman, György Horvath, Ragnar Hultborn, Holger Jensen, Sture Lindegren, Stig Palm, Lars Jacobsson
Radiotherapy and Oncology - 2008 -
Consequences of inadvertent radioiodine treatment of Graves' disease and thyroid cancer in undiagnosed pregnancy. Can we rely on routine pregnancy
testing?
Gertrud Berg, Lars Jacobsson, Ernst Nyström, Katarina Sjögreen Gleisner, Jan Tennvall
Acta oncologica (Stockholm, Sweden) - 2008 -
Lateral spårstabilitet --
slutrapport
Erland Johnson, Gunnar Kjell, Lars Jacobsson, Robert Lillbacka, Elena Kabo, Anders Ekberg
2007 -
Therapeutic efficacy of astatine-211-labeled trastuzumab on radioresistant SKOV-3 tumors in nude
mice.
Stig Palm, Tom Bäck, Ingela Claesson, Anna Danielsson, Jörgen Elgqvist, Sofia Frost, Ragnar Hultborn, Holger Jensen, Sture Lindegren, Lars Jacobsson
International journal of radiation oncology, biology, physics - 2007 -
Relative biological effectiveness of the alpha-particle emitter (211)At for double-strand break induction in human
fibroblasts.
Kristina Claesson, Bo Stenerlöw, Lars Jacobsson, Kerstin Elmroth
Radiation research - 2007 -
Evaluation of reconstruction techniques for lung single photon emission tomography: a Monte Carlo
study.
Pernilla Norberg, Björn Bake, Lars Jacobsson, Gudrun Alm Carlsson, Agnetha Gustafsson
Nuclear medicine communications - 2007 -
Biodistribution of free 225Ac in nude
mice.
Stig Palm, Tom Bäck, Jörgen Elgqvist, Ragnar Hultborn, Helena Kahu, Sture Lindegren, Elisabet Warnhammar, Lars Jacobsson
Cancer Biotherapy and Radiopharmaceuticals - 2006 -
Pharmacokinetics and dosimetry of 211At-MX35 F(ab')2 in therapy of ovarian cancer - preliminary results from an ongoing phase I
study.
Ragnar Hultborn, Håkan Andersson, Tom Bäck, C Divgi, Jörgen Elgqvist, Jakob Himmelman, György Horvath, Holger Jensen, Sture Lindegren, Stig Palm, Lars Jacobsson
Cancer Biotherapy and Radiopharmaceuticals - 2006 -
Administered activity and metastatic cure probability during radioimmunotherapy of ovarian cancer in nude mice with 211At-MX35
F(ab')2.
Jörgen Elgqvist, Håkan Andersson, Peter Bernhardt, Tom Bäck, Ingela Claesson, Ragnar Hultborn, Holger Jensen, Bengt R Johansson, Sture Lindegren, Marita Olsson, Stig Palm, Elisabet Warnhammar Finnborg, Lars Jacobsson
International journal of radiation oncology, biology, physics - 2006 -
Alpha-radioimmunotherapy of intraperitoneally growing OVCAR-3 tumors of variable dimensions: Outcome related to measured tumor size and mean absorbed
dose.
Jörgen Elgqvist, Håkan Andersson, Tom Bäck, Ingela Claesson, Ragnar Hultborn, Holger Jensen, Bengt R Johansson, Sture Lindegren, Marita Olsson, Stig Palm, Elisabet Warnhammar Finnborg, Lars Jacobsson
Journal of nuclear medicine : official publication, Society of Nuclear Medicine - 2006 -
Fractionated radioimmunotherapy of intraperitoneally growing ovarian cancer in nude mice with 211At-MX35 F(ab')2: therapeutic efficacy and
myelotoxicity
Jörgen Elgqvist, Håkan Andersson, Tom Bäck, Ingela Claesson, Ragnar Hultborn, H. Jensen, Sture Lindegren, Marita Olsson, Stig Palm, Elisabet Warnhammar Finnborg, Lars Jacobsson
Nucl Med Biol - 2006 -
Alpha-particle emitter [211At] mediated anticancer efficacy of Trastuzumab: Single-dose and fractionated 211At-Herceptin therapy in a nude mouse ovarian carcinoma
model.
Stig Palm, Tom Bäck, Ingela Claesson, Jörgen Elgqvist, Ragnar Hultborn, Börje Karlsson, Sture Lindegren, Lars Jacobsson
Journal of Nuclear Medicine - 2005 -
211At radioimmunotherapy of subcutaneous human ovarian cancer xenografts: evaluation of relative biologic effectiveness of an alpha-emitter in
vivo
Tom Bäck, Håkan Andersson, C. R. Divgi, Ragnar Hultborn, H. Jensen, Sture Lindegren, Stig Palm, Lars Jacobsson
J Nucl Med - 2005 -
Therapeutic efficacy and tumor dose estimations in radioimmunotherapy of intraperitoneally growing OVCAR-3 cells in nude mice with (211)At-labeled monoclonal antibody
MX35
Jörgen Elgqvist, Håkan Andersson, Tom Bäck, Ragnar Hultborn, H. Jensen, Börje Karlsson, Sture Lindegren, Stig Palm, Elisabet Warnhammar Finnborg, Lars Jacobsson
J Nucl Med - 2005 -
Myelotoxicity and RBE of 211At-conjugated monoclonal antibodies compared with 99mTc-conjugated monoclonal antibodies and 60Co irradiation in nude
mice
Jörgen Elgqvist, Peter Bernhardt, Ragnar Hultborn, H. Jensen, Börje Karlsson, Sture Lindegren, Elisabet Warnhammar Finnborg, Lars Jacobsson
J Nucl Med - 2005 -
A novel photon radiation detector system for in vitro biokinetic
measurements.
Jenny Oddstig, Peter Bernhardt, Lars Jacobsson, Eva Forssell-Aronsson
Cancer biotherapy & radiopharmaceuticals - 2005 -
Antitumor effect of At-211-radioimmunotherapy on subcutaneous human ovarian cancer xenografts: Evaluation of RBE of an alpha emitter in
vivo.
Tom Bäck, Stig Palm, Sture Lindegren, Börje Karlsson, Ragnar Hultborn, Lars Jacobsson
Cancer Biotherapy and Radiopharmaceuticals - 2004 -
Microdosimetry of astatine-211 single-cell irradiation: role of daughter polonium-211
diffusion.
Stig Palm, John L Humm, Robert Rundqvist, Lars Jacobsson
Medical physics - 2004 -
Spårstabilitet - en introduktion för
bantekniker
Elena Kabo, Anders Ekberg, Lars Jacobsson
2004 -
Railway track stability – a state of-the-art
survey
Elena Kabo, Anders Ekberg, Lars Jacobsson
2004 -
[The psychiatric reform was necessary! Normalized life conditions for tens of thousands of
persons]
Karl Grunewald, Lars Jacobsson, Mikael Sandlund, Urban Markström
Läkartidningen - 2004 -
Spinal CSF absorption in healthy
individuals.
Mikael Edsbagge, Magnus Tisell, Lars Jacobsson, Carsten Wikkelsö
American journal of physiology. Regulatory, integrative and comparative physiology - 2004 -
Informed consent in China: quality of information provided to participants in a research
project.
Niels Lynöe, Mikael Sandlund, Lars Jacobsson, Gunnar Nordberg, Taiyi Jin
Scandinavian journal of public health - 2004 -
Astatine-211-labeled antibodies for treatment of disseminated ovarian cancer: an overview of results in an ovarian tumor
model
Håkan Andersson, Jörgen Elgqvist, György Horvath, Ragnar Hultborn, Lars Jacobsson, H. Jensen, Börje Karlsson, Sture Lindegren, Stig Palm
Clin Cancer Res - 2003 -
Single-cell irradiation from [211At] astatine-labeled C215 monoclonal antibody: improved estimates of radiosensitivity from measurements on cellular uptake and
retention
Stig Palm, Tom Bäck, Ingela Claesson, Ulla Delle, Ragnar Hultborn, Sture Lindegren, Lars Jacobsson
Anticancer Res - 2003 -
(211)At-labeled and biotinylated effector molecules for pretargeted radioimmunotherapy using poly-L- and poly-D-Lysine as
multicarriers
Sture Lindegren, Börje Karlsson, Lars Jacobsson, Håkan Andersson, Ragnar Hultborn, G. Skarnemark
Clin Cancer Res - 2003 -
Evaluation of various attenuation corrections in lung SPECT in healthy
subjects
A. Gustafsson, Lars Jacobsson, A. Johansson, Michaela Moonen, Ulf Tylén, Björn Bake
Nuclear Medicine Communications - 2003 -
At-211 labelled antibodies for treatment of disseminated ovarian cancer: an overview of results in an ovarian tumour
model.
Ragnar Hultborn, Håkan Andersson, Tom Bäck, Ingela Claesson, Ulla Delle, Jörgen Elgqvist, György Horvath, Lars Jacobsson, Holger Jensen, Sture Lindegren, Stig Palm, Elisabet Warnhammar Finnborg
Cancer Biotherapy and Radiopharmaceuticals - 2002 -
Comparison of hematological toxicity of the alpha emitter 211At and the electron emitter 99mTc in nude
mice.
Jörgen Elgqvist, Peter Bernhardt, Ragnar Hultborn, Börje Karlsson, Sture Lindegren, Stig Palm, Lars Jacobsson
Cancer Biotherapy and Radiopharmaceuticals - 2002 -
Synthesis and biodistribution of 211At-labeled, biotinylated, and charge-modified poly-L-lysine: evaluation for use as an effector molecule in pretargeted intraperitoneal tumor
therapy.
Sture Lindegren, Håkan Andersson, Lars Jacobsson, Tom Bäck, Gunnar Skarnemark, Börje Karlsson
Bioconjugate chemistry - 2002 -
Exploring the anticancer potential of the alpha-particle emitter
astatine-211.
Stig Palm, Håkan Andersson, Tom Bäck, Ingela Claesson, Ulla Delle, György Horvath, Ragnar Hultborn, Lars Jacobsson, Börje Karlsson, Sture Lindegren
Anticancer Research - 2001 -
Comparison of the therapeutic efficacy of 211At- and 131I-labelled monoclonal antibody MOv18 in nude mice with intraperitoneal growth of human ovarian
cancer.
Håkan Andersson, Stig Palm, Sture Lindegren, Tom Bäck, Lars Jacobsson, Gunilla Leser, György Horvath
Anticancer research - 2001 -
Dosimetrical considerations in astatine-211
radioimmunotherapy
Stig Palm, Lars Jacobsson
Therapeutic applications of radiopharmaceuticals. IAEA-TECDOC-1228 - 2001 -
In vitro effects and microdosimetry of 211At for tumour
therapy.
Stig Palm, Håkan Andersson, Tom Bäck, Ingela Claesson, Ulla Delle, Ragnar Hultborn, Lars Jacobsson, Istvan Köpf, Sture Lindegren
International Journal of Radiation Oncology, Biology, Physics - 2000 -
In vitro effects of free 211At,211At-albumin and 211At-monoclonal antibody compared to external photon irradiation on two human cancer cell
lines
Stig Palm, Håkan Andersson, Tom Bäck, Ingela Claesson, Ulla Delle, Ragnar Hultborn, Lars Jacobsson, Istvan Köpf, Sture Lindegren
Anticancer Res - 2000 -
Cell growth kinetics of the human cell line Colo-205 irradiated with photons and astatine-211
alpha-particles
Stig Palm, Håkan Andersson, Tom Bäck, Ingela Claesson, Ulla Delle, Ragnar Hultborn, Lars Jacobsson, Istvan Köpf, Sture Lindegren
Anticancer Res - 2000 -
Effects of the alpha-particle emitter At-211 and low-dose-rate gamma-radiation on the human cell line Colo-205 as studied with a growth
assay
Stig Palm, Tom Bäck, Ingela Claesson, Ulla Delle, Ragnar Hultborn, Lars Jacobsson, Istvan Köpf, Sture Lindegren
Anticancer Res - 1998 -
The influence of hepatic artery ligation and of vasopressin on liver tumour blood flow in
rats.
Peter Naredi, Per Lindnér, Stig B Holmberg, Rigmor Söderberg, Göran Carlsson, Bengt Gustavsson, Lars Jacobsson, Lars-Olof Hafström
Journal of surgical oncology - 1992 -
Evaluation of blood flow measurements with microspheres and rubidium--an experimental study in
rats.
Peter Naredi, J Mattson, Lars-Olof Hafström, Lars Jacobsson
International journal of microcirculation, clinical and experimental / sponsored by the European Society for Microcirculation - 1990