Li-Ming Gan

• A potent GalNAc-siRNA drug, RBD1016, leads to sustained HBsAg reduction and seroconversion in mouse models of HBV infection

  Shuquan Zheng, Huiqing Cao, Min Zhang, Chun Guo, Xu Yan, Qi Sun, Hongyan Zhang, Zicai Liang, Shan Gao, Li-Ming Gan
  MOLECULAR THERAPY NUCLEIC ACIDS - 2025
• Circulating soluble LOX-1 and patient prognosis after an acute coronary syndrome

  Alexandru Schiopu, Sara Svedlund, Gayathri Narasimhan, Bi Juin Loong, Troels Yndigegn, Vijayalakshmi Varma, Emily L. Ongstad, Isabel Goncalves, Anna Collén, Jan Nilsson, Li-Ming Gan
  Heart - 2025
• Inhibition of Factor XI Using RBD4059: A Novel GalNAc-siRNA With Potent and Durable Antithrombotic Effects

  Junshi Liang, Sofia Nilsson, Johannes Wikström, Huiqing Cao, Shuquan Zheng, Qian Xu, Xu Yan, Sebastian Ueckert, Qi Sun, Chun Guo, Hongyan Zhang, Zicai Liang, Shan Gao, Li-Ming Gan
  JACC: Basic to Translational Science - 2025
• The efficacy and safety of ISIS 449884 injection as monotherapy in patients with type 2 diabetes: A randomized phase II study.

  Linong Ji, Leili Gao, Zhikai Feng, Guoliang Chen, Jing Fu, Erin Morgan, Sanjay Bhanot, Shan Gao, Hongyan Zhang, Zicai Liang, Li-Ming Gan
  Diabetes, obesity and metabolism - 2024
• SGLT2 inhibition improves coronary flow velocity reserve and contractility: role of glucagon signaling

  Sven O. Gopel, Damilola Adingupu, Jue Wang, Elizaveta Semenova, Margareta Behrendt, Rasmus Jansson-Lofmark, Christine Ahlstrom, Ann-Cathrine Jonsson-Rylander, V. Sashi Gopaul, Russell Esterline, Li-Ming Gan, Rui-Ping Xiao
  CARDIOVASCULAR DIABETOLOGY - 2024
• ISIS 449884 Injection Add-On to Metformin in Patients with Type 2 Diabetes: A Randomized, Double-Blind, Placebo-Controlled, Phase II Clinical Study

  Linong Ji, Leili Gao, Zhikai Feng, Guoliang Chen, Jing Fu, Erin Morgan, Sanjay Bhanot, Shan Gao, Hongyan Zhang, Zicai Liang, Li-Ming Gan
  DIABETES THERAPY - 2024
• Cardiometabolic biomarker patterns associated with cardiac MRI defined fibrosis and microvascular dysfunction in patients with heart failure with preserved ejection fraction

  Connor Siggins, Jonathan A. Pan, Adrian I. Loffler, Yang Yang, Peter W. Shaw, Pelbreton C. Balfour, Frederick H. Epstein, Li-Ming Gan, Christopher M. Kramer, Ellen C. Keeley, Michael Salerno
  FRONTIERS IN CARDIOVASCULAR MEDICINE - 2024
• External validation of a deep learning algorithm for automated echocardiographic strain measurements

  Peder L. Myhre, Chung-Lieh Hung, Matthew J. Frost, Zhubo Jiang, Wouter Ouwerkerk, Kanako Teramoto, Sara Svedlund, Antti Saraste, Camilla Hage, Ru-San Tan, Lauren Beussink-Nelson, Maria L. Fermer, Li-Ming Gan, Yoran M. Hummel, Lars H. Lund, Sanjiv J. Shah, Carolyn S. P. Lam, Jasper Tromp
  EUROPEAN HEART JOURNAL - DIGITAL HEALTH - 2024
• Safety and Feasibility Using a Fluid-Filled Wire to Avoid Hydrostatic Errors in Physiological Intracoronary Measurements.

  Truls Råmunddal, Christian Dworeck, Petronella Torild, Sofie Andréen, Li-Ming Gan, Geir Hirlekar, Dan Ioanes, Anna Myredal, Jacob Odenstedt, Petur Petursson, Tetiana Pylova, Fanny Töpel, Sebastian Völz, Mats Hilmersson, Björn Redfors, Oskar Angerås
  Cardiology research and practice - 2024
• Myeloperoxidase Inhibition in Heart Failure With Preserved or Mildly Reduced Ejection Fraction: SATELLITE Trial Results.

  Carolyn S P Lam, Lars H Lund, Sanjiv J Shah, Adriaan A Voors, David Erlinge, Antti Saraste, Carlo Pirazzi, Erik L Grove, Anders Barasa, Morten Schou, Ahmed Aziz, Sara Svedlund, Jan VAN Wijngaarden, Eva-Lotte Lindstedt, Andreas Gustavsson, Karin Nelander, Pavlo Garkaviy, Li-Ming Gan, Anders Gabrielsen
  Journal of cardiac failure - 2023
• Feasibility of high-dose tadalafil and effects on insulin resistance in well-controlled patients with type 2 diabetes (MAKROTAD): a single-centre, double-blind, randomised, placebo-controlled, cross-over phase 2 trial

  Emanuel Fryk, Vagner Ramon Rodrigues Silva, Marco Bauzá-Thorbrügge, M. Schmelz, Li-Ming Gan, Lena Strindberg, Per-Anders Jansson
  Eclinicalmedicine - 2023
• Direct intramyocardial injection of VEGF mRNA in patients undergoing coronary artery bypass grafting

  V. Anttila, A. Saraste, J. Knuuti, M. Hedman, P. Jaakkola, K. L. Laugwitz, M. Krane, Anders Jeppsson, S. Sillanmäki, J. Rosenmeier, P. Zingmark, A. Rudvik, P. Garkaviy, C. Watson, M. N. Pangalos, K. R. Chien, R. Fritsche-Danielson, A. Collén, Li-Ming Gan
  Molecular Therapy - 2023
• Myeloperoxidase Inhibition Reverses Biomarker Profiles Associated With Clinical Outcomes in HFpEF.

  Erik Michaëlsson, Lars H Lund, Camilla Hage, Sanjiv J Shah, Adriaan A Voors, Antti Saraste, Björn Redfors, Erik L Grove, Anders Barasa, A Mark Richards, Sara Svedlund, Maria Lagerström-Fermér, Anders Gabrielsen, Pavlo Garkaviy, Li-Ming Gan, Carolyn S P Lam
  JACC. Heart failure - 2023
• Ticagrelor Treatment is Associated With Increased Coronary Flow Reserve in Survivors of Myocardial Infarction.

  Kristina Torngren, Rebecca Rylance, Li-Ming Gan, Elmir Omerovic, Sara Svedlund, David Erlinge
  Heart, lung & circulation - 2023
• Regional differences and coronary microvascular dysfunction in heart failure with preserved ejection fraction

  M. Erhardsson, U. L. Faxén, A. Venkateshvaran, Sara Svedlund, A. Saraste, M. L. Fermer, Li-Ming Gan, S. J. Shah, J. Tromp, C. S. P. Lam, L. H. Lund, C. Hage
  ESC Heart Failure - 2023
• Association of Epicardial Adipose Tissue with Proteomics, Coronary Flow Reserve, Cardiac Structure and Function, and Quality of Life in Heart Failure with Preserved Ejection Fraction: Insights from the PROMIS-HFpEF study.

  Ashwin Venkateshvaran, Ulrika Ljung Faxen, Camilla Hage, Erik Michaëlsson, Sara Svedlund, Antti Saraste, Lauren Beussink-Nelson, Maria Lagerstrom Fermer, Li-Ming Gan, Jasper Tromp, Carolyn S P Lam, Sanjiv J Shah, Lars H Lund
  European journal of heart failure - 2022
• Safety and efficacy of the 5-lipoxygenase-activating protein inhibitor AZD5718 in patients with recent myocardial infarction: The phase 2a FLAVOUR study.

  Eva Prescott, Oskar Angerås, David Erlinge, Erik L Grove, Marja Hedman, Lisette O Jensen, John Pernow, Antti Saraste, Axel Åkerblom, Sara Svedlund, Anna Rudvik, Jane Knöchel, Eva-Lotte Lindstedt, Pavlo Garkaviy, Li-Ming Gan, Anders Gabrielsen
  International journal of cardiology - 2022
• Targeting inflammation for the treatment of Diabetic Kidney Disease: a five-compartment mechanistic model.

  Alexis Hofherr, Julie Williams, Li-Ming Gan, Magnus Söderberg, Pernille Hansen, Kevin J Woollard
  BMC nephrology - 2022
• Microvesicles in plasma reflect coronary flow reserve in patients with cardiovascular disease.

  Paulina Bryl-Górecka, Kreema James, Kristina Torngren, Inger Haraldsson, Li-Ming Gan, Sara Svedlund, Björn Olde, Thomas Laurell, Elmir Omerovic, David Erlinge
  American journal of physiology. Heart and circulatory physiology - 2021
• Sacubitril/valsartan decreases mortality in the rat model of the isoprenaline-induced takotsubo-like syndrome

  Anwar Ali Gasim Elsied, Björn Redfors, Jessica Alkhoury, Jonatan Oras, Marcus Henricsson, Jan Borén, Elias Björnson, Aaron Shekka Espinosa, Malin Levin, Li-Ming Gan, Elmir Omerovic
  ESC Heart Failure - 2021
• Generalizability of HFA-PEFF and H2FPEF Diagnostic Algorithms and Associations With Heart Failure Indices and Proteomic Biomarkers: Insights From PROMIS-HFpEF

  U. L. Faxen, A. Venkateshvaran, S. J. Shah, C. S. P. Lam, Sara Svedlund, A. Saraste, L. Beussink-Nelson, M. L. Fermer, Li-Ming Gan, C. Hage, L. H. Lund
  Journal of Cardiac Failure - 2021
• Disproportionate left atrial myopathy in heart failure with preserved ejection fraction among participants of the PROMIS-HFpEF study

  R. B. Patel, C. S. P. Lam, Sara Svedlund, A. Saraste, C. Hage, R. S. Tan, L. Beussink-Nelson, J. Tromp, C. Sanchez, J. Njoroge, S. A. Swat, U. L. Faxen, M. L. Fermer, A. Venkateshvaran, Li-Ming Gan, L. H. Lund, S. J. Shah
  Scientific Reports - 2021
• Survival of Patients With Angina Pectoris Undergoing Percutaneous Coronary Intervention With Intracoronary Pressure Wire Guidance.

  Sebastian Völz, Christian Dworeck, Björn Redfors, Petur Petursson, Oskar Angerås, Li-Ming Gan, Matthias Götberg, Giovanna Sarno, Dimitrios Venetsanos, Per Grimfärd, Robin Hoffman, Jens Jensen, Fredrik Björklund, Mikael Danielewicz, Rickard Linder, Truls Råmunddal, Ole Fröbert, Nils Witt, Stefan James, David Erlinge, Elmir Omerovic
  Journal of the American College of Cardiology - 2020
• Proteomic Evaluation of the Comorbidity-Inflammation Paradigm in Heart Failure With Preserved Ejection Fraction Results From the PROMIS-HFpEF Study

  S. Sanders-van Wijk, J. Tromp, L. Beussink-Nelson, C. Hage, Sara Svedlund, A. Saraste, S. A. Swat, C. Sanchez, J. Njoroge, R. S. Tan, M. L. Fermer, Li-Ming Gan, L. H. Lund, C. S. P. Lam, S. J. J. Shah
  Circulation - 2020
• Design and rationale of FLAVOUR: A phase IIa efficacy study of the 5-lipoxygenase activating protein antagonist AZD5718 in patients with recent myocardial infarction.

  Eva Prescott, John Pernow, Antti Saraste, Axel Åkerblom, Oskar Angerås, David Erlinge, Erik L Grove, Marja Hedman, Lisette O Jensen, Sara Svedlund, Magnus Kjaer, Maria Lagerström-Fermér, Li-Ming Gan
  Contemporary clinical trials communications - 2020
• Association of Coronary Microvascular Dysfunction With Heart Failure Hospitalizations and Mortality in Heart Failure With Preserved Ejection Fraction: A Follow-up in the PROMIS-HFpEF Study

  C. Hage, Sara Svedlund, A. Saraste, U. L. Faxen, L. Benson, M. L. Fermer, Li-Ming Gan, S. J. Shah, C. S. P. Lam, L. H. Lund
  Journal of Cardiac Failure - 2020
• The importance of heart rate in isoprenaline-induced takotsubo-like cardiac dysfunction in rats

  Anwar Ali Gasim Elsied, Björn Redfors, Joel Lundgren, Jessica Alkhoury, Jonatan Oras, Li-Ming Gan, Elmir Omerovic
  Esc Heart Failure - 2020
• Myeloperoxidase and related biomarkers are suggestive footprints of endothelial microvascular inflammation in HFpEF patients

  C. Hage, E. Michaelsson, B. Kull, T. Miliotis, S. Svedlund, C. Linde, E. Donal, J. C. Daubert, Li-Ming Gan, L. H. Lund
  Esc Heart Failure - 2020
• Synthetic mRNA Encoding VEGF-A in Patients Undergoing Coronary Artery Bypass Grafting: Design of a Phase 2a Clinical Trial

  V. Anttila, A. Saraste, J. Knuuti, P. Jaakkola, M. Hedman, Sara Svedlund, M. Lagerstrom-Fermer, M. Kjaer, Anders Jeppsson, Li-Ming Gan
  Molecular Therapy-Methods & Clinical Development - 2020
• RNA sequencing data describing transcriptional changes in aorta of ApoE-/mice after alpha 7 nicotinic acetylcholine receptor (alpha 7nAChR) stimulation

  Marcus A Ulleryd, Filip Mjörnstedt, Dimitra Panagaki, Li Jin Yang, Kajsa Engevall, Saray Gutiérrez, Y. X. Wang, Li-Ming Gan, Holger Nilsson, E. Michaelsson, Maria E Johansson
  Data in Brief - 2020
• Identification of novel pheno-groups in heart failure with preserved ejection fraction using machine learning

  A. K. Hedman, C. Hage, A. Sharma, M. J. Brosnan, L. Buckbinder, Li-Ming Gan, S. J. Shah, C. M. Linde, E. Donal, J. C. Daubert, A. Malarstig, D. Ziemek, L. Lund
  Heart - 2020
• Effect of renal denervation on coronary flow reserve in patients with resistant hypertension

  Sebastian Völz, Bert Andersson, Charlotta Ljungman, Li-Ming Gan, Bengt Rundqvist, Sara Svedlund
  Clinical Physiology and Functional Imaging - 2019
• PROspective evaluation of coronary FLOW reserve and molecular biomarkers in patients with established coronary artery disease the PROFLOW-trial: cross-sectional evaluation of coronary flow reserve

  Inger Haraldsson, Li-Ming Gan, Sara Svedlund, K. Torngren, H. U. Westergren, Björn Redfors, M. Lagerstrom-Fermer, Oskar Angerås, Truls Råmunddal, Petur Petursson, Jacob Odenstedt, Per Albertsson, D. Erlinge, Elmir Omerovic
  Vascular Health and Risk Management - 2019
• Extracellular volume by cardiac magnetic resonance is associated with biomarkers of inflammation in hypertensive heart disease

  J. A. Pan, E. Michaëlsson, P. W. Shaw, S. Kuruvilla, C. M. Kramer, Li-Ming Gan, E. C. Keeley, M. Salerno
  Journal of hypertension - 2019
• Cardiac expression of the microsomal triglyceride transport protein protects the heart function during ischemia

  Martina Klevstig, M. Arif, M. Mannila, S. Svedlund, Ismena Mardani, Marcus Ståhlman, Linda Andersson, Malin Lindbom, Azra Miljanovic, A. Franco-Cereceda, P. Eriksson, Anders Jeppsson, Li-Ming Gan, Malin Levin, A. Mardinoglu, E. Ehrenborg, Jan Borén
  Journal of Molecular and Cellular Cardiology - 2019
• Intradermal delivery of modified mRNA encoding VEGF-A in patients with type 2 diabetes

  Li-Ming Gan, M. Lagerstrom-Fermer, L. G. Carlsson, C. Arfvidsson, A. C. Egnell, A. Rudvik, M. Kjaer, A. Collen, J. D. Thompson, J. Joyal, L. Chialda, T. Koernicke, R. Fuhr, K. R. Chien, R. Fritsche-Danielson
  Nature Communications - 2019
• Inhibiting myeloperoxidase prevents onset and reverses established high-fat diet-induced microvascular insulin resistance

  W. D. Chai, K. Aylor, Z. Q. Liu, Li-Ming Gan, E. Michaelsson, E. Barrett
  American Journal of Physiology-Endocrinology and Metabolism - 2019
• Stimulation of alpha 7 nicotinic acetylcholine receptor (α7nAChR) inhibits atherosclerosis via immunomodulatory effects on myeloid cells.

  Marcus A Ulleryd, Filip Mjörnstedt, Dimitra Panagaki, Li Jin Yang, Kajsa Engevall, Saray Gutiérrez, Yixin Wang, Li-Ming Gan, Holger Nilsson, Erik Michaëlsson, Maria E Johansson
  Atherosclerosis - 2019
• SGLT2 inhibition with empagliflozin improves coronary microvascular function and cardiac contractility in prediabetic ob/ob(-/-) mice

  D. D. Adingupu, S. O. Gopel, J. Gronros, M. Behrendt, M. Sotak, T. Miliotis, U. Dahlqvist, Li-Ming Gan, A. C. Jonsson-Rylander
  Cardiovascular Diabetology - 2019
• Prevalence and correlates of coronary microvascular dysfunction in heart failure with preserved ejection fraction: PROMIS-HFpEF

  S. J. Shah, C. S. P. Lam, Sara Svedlund, A. Saraste, C. Hage, R. S. Tan, L. Beussink-Nelson, M. L. Fermer, Li-Ming Gan, L. H. Lund
  European Heart Journal - 2018
• Randomized clinical trial studying effects of a personalized supervised lifestyle intervention program on cardiovascular status in physically inactive healthy volunteers.

  Helena Utkovic Westergren, Li-Ming Gan, Marianne Månsson, Sara Svedlund
  Oncotarget - 2018
• Determinants of coronary flow reserve in non-diabetic patients with chest pain without myocardial perfusion defects

  Helena Utkovic Westergren, E. Michaelsson, Juuso I. Blomster, T. Miliotis, Sara Svedlund, Li-Ming Gan
  PLoS ONE - 2017
• Inflammatory Biomarkers Predict Heart Failure Severity and Prognosis in Patients With Heart Failure With Preserved Ejection Fraction A Holistic Proteomic Approach

  C. Hage, E. Michaelsson, C. Linde, E. Donal, J. C. Daubert, Li-Ming Gan, L. H. Lund
  Circulation-Cardiovascular Genetics - 2017
• Incremental Value of Transthoracic Doppler Echocardiography-Assessed Coronary Flow Reserve in Patients With Suspected Myocardial Ischemia Undergoing Myocardial Perfusion Scintigraphy.

  Li-Ming Gan, Sara Svedlund, Ann Wittfeldt, Charlotte Eklund, Sinsia Gao, Göran Matejka, Anders Jeppsson, Per Albertsson, Elmir Omerovic, Amir Lerman
  Journal of the American Heart Association - 2017
• Radial artery intima-media thickness regresses after secondary prevention interventions in patients' post-acute coronary syndrome and is associated with cardiac and kidney biomarkers

  D. D. Adingupu, Helena Westergren, S. Dahgam, A. C. Jonsson-Rylander, Juuso I. Blomster, Per Albertsson, Elmir Omerovic, Sara Svedlund, Li-Ming Gan
  Oncotarget - 2017
• Coronary flow reserve in patients with resistant hypertension.

  Sebastian Völz, Sara Svedlund, Bert Andersson, Li-Ming Gan, Bengt Rundqvist
  Clinical research in cardiology : official journal of the German Cardiac Society - 2016
• Effects of nitroglycerine on coronary flow velocity before and during adenosine provocation.

  Ann Wittfeldt, Anders Jeppsson, Li-Ming Gan
  Cardiovascular ultrasound - 2016
• Perilipin 5 is protective in the ischemic heart

  Christina Drevinge, K. T. Dalen, M. N. Mannila, Margareta Scharin Täng, Marcus Ståhlman, Martina Klevstig, Annika Lundqvist, Ismena Mardani, F. Haugen, Per Fogelstrand, Martin Adiels, Jorge Asin-Cayuela, C. Ekestam, J. R. Gadin, Y. K. Lee, H. Nebb, Sara Svedlund, Bengt R Johansson, Lillemor Mattsson Hultén, Stefano Romeo, Björn Redfors, Elmir Omerovic, Max Levin, Li-Ming Gan, P. Eriksson, Linda Andersson, E. Ehrenborg, A. R. Kimmel, Jan Borén, Malin Levin
  International Journal of Cardiology - 2016
• Coronary flow reserve as a link between exercise capacity, cardiac systolic and diastolic function

  Juuso I. Blomster, Sara Svedlund, Helena Utkovic Westergren, Li-Ming Gan
  International Journal of Cardiology - 2016
• Insulin Enhances Endothelial Function Throughout the Arterial Tree in Healthy But Not Metabolic Syndrome Subjects

  L. A. Jahn, L. Hartline, N. Rao, B. Logan, J. J. Kim, K. Aylor, Li-Ming Gan, Helena Westergren, E. J. Barrett
  Journal of Clinical Endocrinology & Metabolism - 2016

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