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Jonas Nilsson
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"Målet" för Jonas Nilsson är att en dag kunna bota cancer, att hitta nya behandlingar, med så få biverkningar som möjligt. Om detta och lite till kan du läsa i en artikel om Jonas Nilssons forskning och en i annan artikel från GU-journalen nr 3-2017
Läs mer om Jonas Nilsson Group på Sahlgrenska Translational Melanoma Group (SATMEG)
Research Summary SATMEG We try to identify new means to treat cancer based on our previous research on the oncogenic transcription factor c-Myc. This research has pointed on potential targets for anti-cancer drugs including kinases, epigenetic readers and metabolic enzymes. Recently the group's activities has shifted into translating the knowledge gained from the Myc research into melanoma. Myc is overexpressed in melanoma so therefore its expression is not an optimal biomarker to define which of our previously identified targets would be viable in melanoma. Our new research therefore seek to identify biomarkers of response to new targeted therapies.
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The Transcriptomic and Gene Fusion Landscape of Pleomorphic Salivary Gland
Adenomas
Maryam K. Afshari, Paloma Nevado, Andre Fehr, Junchi Huang, Fredrik Jäwert, Jonas A Nilsson, Göran Stenman, Mattias K Andersson
GENES CHROMOSOMES & CANCER - 2025 -
Pericyte phenotype switching alleviates immunosuppression and sensitizes vascularized tumors to immunotherapy in preclinical
models
Zhi Jie Li, Bo He, Alice Domenichini, Jiulia Satiaputra, Kira H. Wood, Devina D. Lakhiani, Abate A. Bashaw, Lisa M Nilsson, Ji Li, Edward R. Bastow, Anna Johansson-Percival, Elena Denisenko, Alistair R.R. Forrest, Suraj Sakaram, Rafael Carretero, Günter J. Hämmerling, Jonas A Nilsson, Gabriel Y.F. Lee, Ruth Ganss
The Journal of clinical investigation - 2024 -
Transcriptional rewiring in CD8+ T cells: implications for CAR-T cell therapy against solid
tumours
Shamini Srinivasan, Jesse Armitage, Jonas A Nilsson, Jason Waithman
FRONTIERS IN IMMUNOLOGY - 2024 -
Patient-derived xenografts and single-cell sequencing identifies three subtypes of tumor-reactive lymphocytes in uveal melanoma
metastase
Joakim Karlsson, Vasu R. Sah, Roger Olofsson Bagge, Irina Kuznetsova, Munir Iqba, Samuel Alsén, Sofia Stenqvist, Alka Saxena, Lars Ny, Lisa M Nilsson, Jonas A Nilsson
ELIFE - 2024 -
A pilocytic astrocytoma with novel ATG16L1::NTRK2 fusion responsive to larotrectinib: a case report with genomic and functional
analysis
Lily Deland, Simon Keane, Thomas Olsson Bontell, Tomas Sjoberg Bexelius, Inga Gudinaviciene, Esther De La Cuesta, Francesca De Luca, Jonas A Nilsson, Helena Carén, Helena Morse, Frida Abel
ONCOLOGIST - 2024 -
The effect of a single dose of nivolumab prior to isolated limb perfusion for patients with in-transit melanoma metastases: An interim analysis of a phase Ib/II randomized double-blind placebo-controlled trial (NivoILP
trial)
Carl Jacob Holmberg, Lisanne P. Zijlker, Dimitrios Katsarelias, Anne Huibers, Michel W.J.M. Wouters, Yvonne Schrage, Sophie J.M. Reijers, Johannes V. van Thienen, Dirk J. Grünhagen, Anna Martner, Jonas A Nilsson, Alexander C.J. van Akkooi, Lars Ny, Winan J. van Houdt, Roger Olofsson Bagge
European Journal of Surgical Oncology - 2024 -
A phase Ib randomized multicenter trial of isolated hepatic perfusion in combination with ipilimumab and nivolumab for uveal
melanoma
Roger Olofsson Bagge, Axel Nelson, A. Shafazand, Christian Cahlin, A. Carneiro, H. Helgadottir, Max Levin, Magnus Rizell, G. Ullenhag, S. Wiren, Per Lindner, Jonas A Nilsson, Lars Ny
ESMO OPEN - 2024 -
MYB alternative promoter activity is increased in adenoid cystic carcinoma metastases and is associated with a specific gene expression
signature
Junchi Huang, Andre Fehr, Fredrik Jäwert, Jonas A Nilsson, Luc G. T. Morris, Göran Stenman, Mattias K Andersson
ORAL ONCOLOGY - 2024 -
Chemokine Analysis in Patients with Metastatic Uveal Melanoma Suggests a Role for CCL21 Signaling in Combined Epigenetic Therapy and Checkpoint
Immunotherapy
Vasu R. Sah, Henrik Jespersen, J. Karlsson, L. M. Nilsson, M. Bergqvist, I. Johansson, A. Carneiro, H. Helgadottir, Max Levin, G. Ullenhag, Anders Ståhlberg, Roger Olofsson Bagge, Jonas A Nilsson, Lars Ny
Cancer Research Communications - 2023 -
Isolated Hepatic Perfusion With Melphalan for Patients With Isolated Uveal Melanoma Liver Metastases: A Multicenter, Randomized, Open-Label, Phase III Trial (the SCANDIUM
Trial)
Roger Olofsson Bagge, Axel Nelson, A. Shafazand, C. All-Eriksson, Christian Cahlin, N. Elander, H. Helgadottir, J. F. Kiilgaard, S. Kinhult, I. Ljuslinder, J. Mattsson, Magnus Rizell, Malin Sternby Eilard, G. J. Ullenhag, Jonas A Nilsson, Lars Ny, Per Lindnér
Journal of Clinical Oncology - 2023 -
SARS-CoV-2 replicates and displays oncolytic properties in clear cell and papillary renal cell
carcinoma
Oi Kuan Choong, Rasmus Jakobsson, Anna Grenabo Bergdahl, Sofia Brunet, Ambjörn Kärmander, Jesper Waldenström, Yvonne Arvidsson, Gülay Altiparmak, Jonas A Nilsson, Joakim Karlsson, Kristina Nyström, Martin E Johansson
Plos One - 2023 -
Subtyping of cardiac amyloidosis by mass spectrometry-based proteomics of endomyocardial
biopsies.
Fredrik Noborn, Christer Thomsen, Egor Vorontsov, Emanuele Bobbio, Carina Sihlbom, Jonas A Nilsson, Christian Lars Polte, Entela Bollano, Kristina Vukusic, Joakim Sandstedt, Göran Dellgren, Kristjan Karason, Anders Oldfors, Göran Larson
Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis - 2023 -
Treatment with Anti-HER2 Chimeric Antigen Receptor Tumor-Infiltrating Lymphocytes (CAR-TILs) Is Safe and Associated with Antitumor Efficacy in Mice and Companion
Dogs
Elin Forsberg, Rebecca E Riise, S. Saellstrom, Joakim Karlsson, Samuel Alsén, Valentina Bucher, A. E. Hemminki, Roger Olofsson Bagge, Lars Ny, Lisa M Nilsson, H. Ronnberg, Jonas A Nilsson
Cancers - 2023 -
Genetics and Therapeutic Responses to Tumor-infiltrating Lymphocyte Therapy of Pancreatic Cancer Patient-derived Xenograft
Models
Caroline Vilhav, Lisa M Nilsson, Joakim Karlsson, Johan Bourghardt Fagman, Daniel Giglio, Cecilia Engström, Peter Naredi, Jonas A Nilsson
HPB - 2023 -
A Fraction of CD8+T Cells from Colorectal Liver Metastases Preferentially Repopulate Autologous Patient-Derived Xenograft Tumors as Tissue-Resident Memory T
Cells
Frank Liang, Lisa M Nilsson, Fabian Byvald, Azar Rezapour, Helena Taflin, Jonas A Nilsson, Ulf Yrlid
Cancers - 2022 -
Epigenetic therapy to enhance therapeutic effects of PD-1 inhibition in therapy-resistant
melanoma
Vasu R. Sah, Joakim Karlsson, Henrik Jespersen, Mattias F Lindberg, Lisa M Nilsson, Lars Ny, Jonas A Nilsson
Melanoma Research - 2022 -
Genetics and Therapeutic Responses to Tumor-Infiltrating
Lymphocyte Therapy of Pancreatic Cancer Patient-Derived
Xenograft
Models
Lisa M Nilsson, Caroline Vilhav, Joakim Karlsson, Johan Bourghardt Fagman, Daniel Giglio, Cecilia Engström, Peter Naredi, Jonas A Nilsson
Gastro Hep Advances - 2022 -
The PEMDAC phase 2 study of pembrolizumab and entinostat in patients with metastatic uveal
melanoma
Lars Ny, Henrik Jespersen, Joakim Karlsson, Samuel Alsén, Stefan Filges, C. All-Eriksson, B. Andersson, A. Carneiro, H. Helgadottir, Max Levin, I. Ljuslinder, Roger Olofsson Bagge, Vasu R. Sah, Ulrika Stierner, Anders Ståhlberg, G. Ullenhag, Lisa M Nilsson, Jonas A Nilsson
Nature Communications - 2021 -
Domain Mapping of Chondroitin/Dermatan Sulfate Glycosaminoglycans Enables Structural Characterization of
Proteoglycans
Andrea Persson, Mahnaz Nikpour, Egor Vorontsov, Jonas A Nilsson, Göran Larson
Molecular & Cellular Proteomics - 2021 -
Intussusceptive angiogenesis in human metastatic malignant
melanoma.
Ankur Pandita, Matias Ekstrand, Sara Bjursten, Zhiyuan Zhao, Per Fogelstrand, Kristell Le Gal, Lars Ny, Martin O Bergo, Joakim Karlsson, Jonas A Nilsson, Levent Akyürek, Malin Levin, Jan Borén, Andrew J Ewald, Keith E Mostov, Max Levin
The American Journal of Pathology - 2021 -
Pharmacologic RNA splicing modulation: a novel mechanism to enhance neoantigen-directed anti-tumor immunity and immunotherapy
response
Kerryn Elliott, Jonas A Nilsson, J. Van den Eynden
Signal Transduction and Targeted Therapy - 2021 -
BET bromodomain inhibitor HMBA synergizes with MEK inhibition in treatment of malignant
glioma
Elisa Funck-Brentano, Dzeneta Vizlin-Hodzic, Jonas A Nilsson, Lisa M Nilsson
Epigenetics - 2021 -
The Microenvironment of Small Intestinal Neuroendocrine Tumours Contains Lymphocytes Capable of Recognition and Activation after
Expansion
Tobias Hofving, Frank Liang, Joakim Karlsson, Ulf Yrlid, Jonas A Nilsson, Ola Nilsson, Lisa M Nilsson
Cancers - 2021 -
Discovery of a rare GKAP1-NTRK2 fusion in a pediatric low-grade glioma, leading to targeted treatment with TRK-inhibitor
larotrectinib.
Lily Deland, Simon Keane, Thomas Olsson Bontell, Helene Sjögren, Henrik Fagman, Ingrid Øra, Esther De La Cuesta, Magnus Tisell, Jonas A Nilsson, Katarina Ejeskär, Magnus Sabel, Frida Abel
Cancer biology & therapy - 2021 -
Small molecule inhibitors and a kinase-dead expressing mouse model demonstrate that the kinase activity of Chk1 is essential for mouse embryos and cancer
cells
Somsundar Veppil Muralidharan, Lisa M Nilsson, Mattias F Lindberg, Jonas A Nilsson
Life Science Alliance - 2020 -
The Effect of Beta-Adrenergic Blocking Agents in Cutaneous Melanoma-A Nation-Wide Swedish Population-Based Retrospective Register
Study.
Dimitrios Katsarelias, Hanna Eriksson, Rasmus Mikiver, Isabelle Krakowski, Jonas A Nilsson, Lars Ny, Roger Olofsson
Cancers - 2020 -
Molecular profiling of driver events in metastatic uveal
melanoma
Joakim Karlsson, Lisa M Nilsson, Suman Mitra, Samuel Alsén, Ganesh V Shelke, Vasu R. Sah, Elin Forsberg, Ulrika Stierner, C. All-Eriksson, Berglind Osk Einarsdottir, Henrik Jespersen, Lars Ny, Per Lindnér, Erik Larsson, Roger Olofsson Bagge, Jonas A Nilsson
Nature Communications - 2020 -
SUMO pathway inhibition targets an aggressive pancreatic cancer
subtype
A. Biederstädt, Z. Hassan, C. Schneeweis, M. Schick, L. Schneider, A. Muckenhuber, Y. Hong, G. Siegers, Lisa M Nilsson, M. Wirth, Z. Dantes, K. Steiger, K. Schunck, S. Langston, H. P. Lenhof, A. Coluccio, F. Orben, J. Slawska, A. Scherger, D. Saur, S. Müller, R. Rad, W. Weichert, Jonas A Nilsson, M. Reichert, G. Schneider, U. Keller
Gut - 2020 -
Supporting clinical decision making in advanced melanoma by preclinical testing in personalized immune-humanized xenograft mouse
models
Lars Ny, Larissa Rizzo, Valerio Belgrano, Jón Karlsson, Henrik Jespersen, Louise Carstam, Roger Olofsson Bagge, Lisa M Nilsson, Jonas A Nilsson
Annals of Oncology - 2020 -
Endosomal signalling via exosome surface TGF
beta-1
Ganesh V Shelke, Yanan Yin, Su Chul Jang, Cecilia Lässer, S. Wennmalm, H. J. Hoffmann, L. Li, Y. S. Gho, Jonas A Nilsson, Jan Lötvall
Journal of Extracellular Vesicles - 2019 -
HER2 CAR-T Cells Eradicate Uveal Melanoma and T-cell Therapy-Resistant Human Melanoma in IL2 Transgenic NOD/SCID IL2 Receptor Knockout
Mice
Elin Forsberg, Mattias F Lindberg, Henrik Jespersen, Samuel Alsén, Roger Olofsson Bagge, M. Donia, I. M. Svane, Ola Nilsson, Lars Ny, Lisa M Nilsson, Jonas A Nilsson
Cancer Research - 2019 -
Clinical, genetic and experimental studies of the Brooke-Spiegler (CYLD) skin tumor
syndrome
Mattias K Andersson, Lars Kölby, Jonas A Nilsson, Göran Stenman
Journal of Plastic Surgery and Hand Surgery - 2019 -
Concomitant use of pembrolizumab and entinostat in adult patients with metastatic uveal melanoma (PEMDAC study): protocol for a multicenter phase II open label
study.
Henrik Jespersen, Roger Olofsson Bagge, Gustav Ullenhag, Ana Carneiro, Hildur Helgadottir, Ingrid Ljuslinder, Max Levin, Charlotta All-Eriksson, Bengt Andersson, Ulrika Stierner, Lisa M Nilsson, Jonas A Nilsson, Lars Ny
BMC cancer - 2019 -
H-STS, L-STS and KRJ-I are not authentic GEPNET cell
lines.
Tobias Hofving, Joakim Karlsson, Ola Nilsson, Jonas A Nilsson
Nature genetics - 2019 -
Response and Toxicity of Repeated Isolated Limb Perfusion (re-ILP) for Patients With In-Transit Metastases of Malignant
Melanoma.
Valerio Belgrano, Jessica Pettersson, Jonas A Nilsson, Jan Mattsson, Dimitrios Katsarelias, Roger Olofsson Bagge
Annals of surgical oncology - 2019 -
BRAF status as a predictive factor for response in isolated limb
perfusion.
Valerio Belgrano, Jan Mattsson, Jonas A Nilsson, Roger Olofsson Bagge, Dimitrios Katsarelias
International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group - 2019 -
A patient-derived xenograft pre-clinical trial reveals treatment responses and a resistance mechanism to karonudib in metastatic
melanoma
Berglind Osk Einarsdottir, Joakim Karlsson, Elin Söderberg, Mattias F Lindberg, Elisa Funck-Brentano, Henrik Jespersen, Siggeir Fannar Brynjólfsson, Roger Olofsson Bagge, Louise Carstam, M. Scobie, T. Koolmeister, O. Wallner, Ulrika Stierner, U. W. Berglund, Lars Ny, Lisa M Nilsson, Erik Larsson, T. Helleday, Jonas A Nilsson
Cell Death & Disease - 2018 -
Anti-Leukemic Properties of Histamine in Monocytic Leukemia: The Role of
NOX2
Roberta Kiffin, Hanna Grauers Wiktorin, Malin S. Nilsson, Johan Aurelius, Ebru Aydin, Brianna Lenox, Jonas A Nilsson, Anders Ståhlberg, Fredrik Bergh Thorén, Kristoffer Hellstrand, Anna Martner
Frontiers in Oncology - 2018 -
Mouse avatars take off as cancer
models.
Jonas A Nilsson, Roger Olofsson Bagge, Lars Ny
Nature - 2018 -
Pathogenesis and therapeutic targeting of aberrant MYC expression in haematological
cancers
M. Schick, S. Habringer, Jonas A Nilsson, U. Keller
British Journal of Haematology - 2017 -
BET bromodomain inhibitors synergize with ATR inhibitors in melanoma in
melanoma.
Somsundar Veppil Muralidharan, Berglind Osk Einarsdottir, Joydeep Bhadury, Mattias F Lindberg, Jin Wu, Eric Campeau, Roger Olofsson Bagge, Ulrika Stierner, Lars Ny, Lisa M Nilsson, Jonas A Nilsson
Cell Death & Disease - 2017 -
Complement peptide C3a stimulates neural plasticity after experimental brain
ischaemia.
Anna Stokowska, Alison L Atkins, Javier Morán, Tulen Pekny, Linda Bulmer, Michaela C. Pascoe, Scott R Barnum, Rick A Wetsel, Jonas A Nilsson, Mike Dragunow, Marcela Pekna
Brain - 2017 -
Clinical responses to adoptive T-cell transfer can be modeled in an autologous immune-humanized mouse
model.
Henrik Jespersen, Mattias F Lindberg, Marco Donia, Elin Söderberg, Rikke Andersen, Ulrich Keller, Lars Ny, Inge Marie Svane, Lisa M Nilsson, Jonas A Nilsson
Nature communications - 2017 -
An approach to suppress the evolution of resistance in BRAF(V600E)-mutant
cancer
Y. H. Xue, L. Martelotto, T. Baslan, A. Vides, M. Solomon, T. T. Mai, N. Chaudhary, G. J. Riely, B. T. Li, K. Scott, F. Cechhi, Ulrika Stierner, K. Chadalavada, E. de Stanchina, S. Schwartz, T. Hembrough, G. Nanjangud, Jonas A Nilsson, S. W. Lowe, J. Reis, N. Rosen, P. Lito
Nat Med - 2017 -
BRAF(V600) inhibition alters the microRNA cargo in the vesicular secretome of malignant melanoma
cells
Taral R Lunavat, L. Cheng, Berglind Osk Einarsdottir, Roger Olofsson Bagge, Somsundar Veppil Muralidharan, R. A. Sharples, Cecilia Lässer, Y. S. Gho, A. F. Hill, Jonas A Nilsson, Jan Lötvall
Proceedings of the National Academy of Sciences of the United States of America - 2017 -
Validation and development of MTH1 inhibitors for treatment of
cancer
U. W. Berglund, K. Sanjiv, H. Gad, C. Kalderen, T. Koolmeister, T. Pham, C. Gokturk, R. Jafari, G. Maddalo, B. Seashore-Ludlow, A. Chernobrovkin, A. Manoilov, I. S. Pateras, A. Rasti, A. S. Jemth, I. Almlof, O. Loseva, T. Visnes, Berglind Osk Einarsdottir, F. Z. Gaugaz, A. Saleh, B. Platzack, O. A. Wallner, K. S. A. Vallin, M. Henriksson, P. Wakchaure, S. Borhade, P. Herr, Y. Kallberg, P. Baranczewski, E. J. Homan, E. Wiita, V. Nagpal, T. Meijer, N. Schipper, S. G. Rudd, L. Brautigam, A. Lindqvist, A. Filppula, T. C. Lee, P. Artursson, Jonas A Nilsson, V. G. Gorgoulis, J. Lehtio, R. A. Zubarev, M. Scobie, T. Helleday
Annals of Oncology - 2016 -
Cancer Differentiating Agent Hexamethylene Bisacetamide Inhibits BET Bromodomain
Proteins
Lisa M Nilsson, Lydia C. Green, Somsundar Veppil Muralidharan, Dagsu Demir, M. Welin, Joydeep Bhadury, D. T. Logan, B. Walse, Jonas A Nilsson
Cancer Research - 2016 -
RNAi delivery by exosome-mimetic nanovesicles - Implications for targeting c-Myc in
cancer
Taral R Lunavat, Su Chul Jang, Lisa M Nilsson, Hyun Taek Park, Gabriela Repiska, Cecilia Lässer, Jonas A Nilsson, Yong Song Gho, Jan Lötvall
Biomaterials - 2016 -
BET bromodomain inhibitors synergize with ATR inhibitors to induce DNA damage, apoptosis, senescence-associated secretory pathway and ER stress in Myc-induced lymphoma
cells.
Somsundar Veppil Muralidharan, Joydeep Bhadury, Lisa M Nilsson, Lydia C. Green, K G McLure, Jonas A Nilsson
Oncogene - 2016 -
Hypoxia-regulated gene expression explains differences between melanoma cell line-derived xenografts and patient-derived
xenografts.
Joydeep Bhadury, Berglind Osk Einarsdottir, Agnieszka Podraza, Roger Olofsson Bagge, Ulrika Stierner, Lars Ny, Marcela Davila Lopez, Jonas A Nilsson
Oncotarget - 2016
Fler publikationer
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