Jonas Nilsson
Om Jonas Nilsson
"Målet" för Jonas Nilsson är att en dag kunna bota cancer, att hitta nya behandlingar, med så få biverkningar som möjligt. Om detta och lite till kan du läsa i en artikel om Jonas Nilssons forskning och en i annan artikel från GU-journalen nr 3-2017
Läs mer om Jonas Nilsson Group på Sahlgrenska Translational Melanoma Group (SATMEG)
Research Summary SATMEG We try to identify new means to treat cancer based on our previous research on the oncogenic transcription factor c-Myc. This research has pointed on potential targets for anti-cancer drugs including kinases, epigenetic readers and metabolic enzymes. Recently the group's activities has shifted into translating the knowledge gained from the Myc research into melanoma. Myc is overexpressed in melanoma so therefore its expression is not an optimal biomarker to define which of our previously identified targets would be viable in melanoma. Our new research therefore seek to identify biomarkers of response to new targeted therapies.
-
SUMO pathway inhibition targets an aggressive pancreatic cancer
subtype
A. Biederstädt, Z. Hassan, C. Schneeweis, M. Schick, L. Schneider, A. Muckenhuber, Y. Hong, G. Siegers, Lisa M Nilsson, M. Wirth, Z. Dantes, K. Steiger, K. Schunck, S. Langston, H. P. Lenhof, A. Coluccio, F. Orben, J. Slawska, A. Scherger, D. Saur, S. Müller, R. Rad, W. Weichert, Jonas A Nilsson, M. Reichert, G. Schneider, U. Keller
Gut - 2020-01-01 -
Small molecule inhibitors and a kinase-dead expressing mouse model demonstrate that the kinase activity of Chk1 is essential for mouse embryos and cancer
cells
Somsundar Veppil Muralidharan, Lisa M Nilsson, Mattias F Lindberg, Jonas A Nilsson
Life Science Alliance - 2020-01-01 -
BET bromodomain inhibitor HMBA synergizes with MEK inhibition in treatment of malignant
glioma
Elisa Funck-Brentano, Dzeneta Vizlin-Hodzic, Jonas A Nilsson, Lisa M Nilsson
Epigenetics - 2020-01-01 -
Molecular profiling of driver events in metastatic uveal
melanoma
Joakim Karlsson, Lisa M Nilsson, Suman Mitra, Samuel Alsén, Ganesh V Shelke, Vasu R. Sah, Elin Forsberg, Ulrika Stierner, C. All-Eriksson, Berglind Osk Einarsdottir, Henrik Jespersen, Lars Ny, Per Lindnér, Erik Larsson, Roger Olofsson Bagge, Jonas A Nilsson
Nature Communications - 2020-01-01 -
Supporting clinical decision making in advanced melanoma by preclinical testing in personalized immune-humanized xenograft mouse
models
Lars Ny, Larissa Rizzo, Valerio Belgrano, Jón Karlsson, Henrik Jespersen, Louise Carstam, Roger Olofsson Bagge, Lisa M Nilsson, Jonas A Nilsson
Annals of Oncology - 2020-01-01 -
Concomitant use of pembrolizumab and entinostat in adult patients with metastatic uveal melanoma (PEMDAC study): protocol for a multicenter phase II open label
study.
Henrik Jespersen, Roger Olofsson Bagge, Gustav Ullenhag, Ana Carneiro, Hildur Helgadottir, Ingrid Ljuslinder, Max Levin, Charlotta All-Eriksson, Bengt Andersson, Ulrika Stierner, Lisa M Nilsson, Jonas A Nilsson, Lars Ny
BMC cancer - 2019-01-01 -
Clinical, genetic and experimental studies of the Brooke-Spiegler (CYLD) skin tumor
syndrome
Mattias K Andersson, Lars Kölby, Jonas A Nilsson, Göran Stenman
Journal of Plastic Surgery and Hand Surgery - 2019-01-01 -
Endosomal signalling via exosome surface TGF
beta-1
Ganesh V Shelke, Yanan Yin, Su Chul Jang, Cecilia Lässer, S. Wennmalm, H. J. Hoffmann, L. Li, Y. S. Gho, Jonas A Nilsson, Jan Lötvall
Journal of Extracellular Vesicles - 2019-01-01 -
HER2 CAR-T Cells Eradicate Uveal Melanoma and T-cell Therapy-Resistant Human Melanoma in IL2 Transgenic NOD/SCID IL2 Receptor Knockout
Mice
Elin Forsberg, Mattias F Lindberg, Henrik Jespersen, Samuel Alsén, Roger Olofsson Bagge, M. Donia, I. M. Svane, Ola Nilsson, Lars Ny, Lisa M Nilsson, Jonas A Nilsson
Cancer Research - 2019-01-01 -
H-STS, L-STS and KRJ-I are not authentic GEPNET cell
lines.
Tobias Hofving, Joakim Karlsson, Ola Nilsson, Jonas A Nilsson
Nature genetics - 2019-01-01 -
BRAF status as a predictive factor for response in isolated limb
perfusion.
Valerio Belgrano, Jan Mattsson, Jonas A Nilsson, Roger Olofsson Bagge, Dimitrios Katsarelias
International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group - 2019-01-01 -
Response and Toxicity of Repeated Isolated Limb Perfusion (re-ILP) for Patients With In-Transit Metastases of Malignant
Melanoma.
Valerio Belgrano, Jessica Pettersson, Jonas A Nilsson, Jan Mattsson, Dimitrios Katsarelias, Roger Olofsson Bagge
Annals of surgical oncology - 2019-01-01 -
Mouse avatars take off as cancer
models.
Jonas A Nilsson, Roger Olofsson Bagge, Lars Ny
Nature - 2018-01-01 -
Anti-Leukemic Properties of Histamine in Monocytic Leukemia: The Role of
NOX2
Roberta Kiffin, Hanna Grauers Wiktorin, Malin S. Nilsson, Johan Aurelius, Ebru Aydin, Brianna Lenox, Jonas A Nilsson, Anders Ståhlberg, Fredrik Bergh Thorén, Kristoffer Hellstrand, Anna Martner
Frontiers in Oncology - 2018-01-01 -
A patient-derived xenograft pre-clinical trial reveals treatment responses and a resistance mechanism to karonudib in metastatic
melanoma
Berglind Osk Einarsdottir, Joakim Karlsson, Elin Söderberg, Mattias F Lindberg, Elisa Funck-Brentano, Henrik Jespersen, Siggeir Fannar Brynjólfsson, Roger Olofsson Bagge, Louise Carstam, M. Scobie, T. Koolmeister, O. Wallner, Ulrika Stierner, U. W. Berglund, Lars Ny, Lisa M Nilsson, Erik Larsson, T. Helleday, Jonas A Nilsson
Cell Death & Disease - 2018-01-01 -
BET bromodomain inhibitors synergize with ATR inhibitors in melanoma in
melanoma.
Somsundar Veppil Muralidharan, Berglind Osk Einarsdottir, Joydeep Bhadury, Mattias F Lindberg, Jin Wu, Eric Campeau, Roger Olofsson Bagge, Ulrika Stierner, Lars Ny, Lisa M Nilsson, Jonas A Nilsson
Cell Death & Disease - 2017-01-01 -
Pathogenesis and therapeutic targeting of aberrant MYC expression in haematological
cancers
M. Schick, S. Habringer, Jonas A Nilsson, U. Keller
British Journal of Haematology - 2017-01-01 -
Clinical responses to adoptive T-cell transfer can be modeled in an autologous immune-humanized mouse
model.
Henrik Jespersen, Mattias F Lindberg, Marco Donia, Elin Söderberg, Rikke Andersen, Ulrich Keller, Lars Ny, Inge Marie Svane, Lisa M Nilsson, Jonas A Nilsson
Nature communications - 2017-01-01 -
BRAF(V600) inhibition alters the microRNA cargo in the vesicular secretome of malignant melanoma
cells
Taral R Lunavat, L. Cheng, Berglind Osk Einarsdottir, Roger Olofsson Bagge, Somsundar Veppil Muralidharan, R. A. Sharples, Cecilia Lässer, Y. S. Gho, A. F. Hill, Jonas A Nilsson, Jan Lötvall
Proceedings of the National Academy of Sciences of the United States of America - 2017-01-01 -
An approach to suppress the evolution of resistance in BRAF(V600E)-mutant
cancer
Y. H. Xue, L. Martelotto, T. Baslan, A. Vides, M. Solomon, T. T. Mai, N. Chaudhary, G. J. Riely, B. T. Li, K. Scott, F. Cechhi, Ulrika Stierner, K. Chadalavada, E. de Stanchina, S. Schwartz, T. Hembrough, G. Nanjangud, Jonas A Nilsson, S. W. Lowe, J. Reis, N. Rosen, P. Lito
Nat Med - 2017-01-01 -
Complement peptide C3a stimulates neural plasticity after experimental brain
ischaemia.
Anna Stokowska, Alison L Atkins, Javier Morán, Tulen Pekny, Linda Bulmer, Michaela C. Pascoe, Scott R Barnum, Rick A Wetsel, Jonas A Nilsson, Mike Dragunow, Marcela Pekna
Brain - 2017-01-01 -
RNAi delivery by exosome-mimetic nanovesicles - Implications for targeting c-Myc in
cancer
Taral R Lunavat, Su Chul Jang, Lisa M Nilsson, Hyun Taek Park, Gabriela Repiska, Cecilia Lässer, Jonas A Nilsson, Yong Song Gho, Jan Lötvall
Biomaterials - 2016-01-01 -
Validation and development of MTH1 inhibitors for treatment of
cancer
U. W. Berglund, K. Sanjiv, H. Gad, C. Kalderen, T. Koolmeister, T. Pham, C. Gokturk, R. Jafari, G. Maddalo, B. Seashore-Ludlow, A. Chernobrovkin, A. Manoilov, I. S. Pateras, A. Rasti, A. S. Jemth, I. Almlof, O. Loseva, T. Visnes, Berglind Osk Einarsdottir, F. Z. Gaugaz, A. Saleh, B. Platzack, O. A. Wallner, K. S. A. Vallin, M. Henriksson, P. Wakchaure, S. Borhade, P. Herr, Y. Kallberg, P. Baranczewski, E. J. Homan, E. Wiita, V. Nagpal, T. Meijer, N. Schipper, S. G. Rudd, L. Brautigam, A. Lindqvist, A. Filppula, T. C. Lee, P. Artursson, Jonas A Nilsson, V. G. Gorgoulis, J. Lehtio, R. A. Zubarev, M. Scobie, T. Helleday
Annals of Oncology - 2016-01-01 -
BET bromodomain inhibitors synergize with ATR inhibitors to induce DNA damage, apoptosis, senescence-associated secretory pathway and ER stress in Myc-induced lymphoma
cells.
Somsundar Veppil Muralidharan, Joydeep Bhadury, Lisa M Nilsson, Lydia C. Green, K G McLure, Jonas A Nilsson
Oncogene - 2016-01-01 -
Hypoxia-regulated gene expression explains differences between melanoma cell line-derived xenografts and patient-derived
xenografts.
Joydeep Bhadury, Berglind Osk Einarsdottir, Agnieszka Podraza, Roger Olofsson Bagge, Ulrika Stierner, Lars Ny, Marcela Davila Lopez, Jonas A Nilsson
Oncotarget - 2016-01-01 -
Cancer Differentiating Agent Hexamethylene Bisacetamide Inhibits BET Bromodomain
Proteins
Lisa M Nilsson, Lydia C. Green, Somsundar Veppil Muralidharan, Dagsu Demir, M. Welin, Joydeep Bhadury, D. T. Logan, B. Walse, Jonas A Nilsson
Cancer Research - 2016-01-01 -
Long-Term Follow-Up Evaluation of 68 Patients with Uveal Melanoma Liver Metastases Treated with Isolated Hepatic
Perfusion.
Ilan Ben-Shabat, Valerio Belgrano, Lars Ny, Jonas A Nilsson, Per Lindnér, Roger Olofsson Bagge
Annals of surgical oncology - 2016-01-01 -
Antioxidants can increase melanoma metastasis in
mice.
Kristell Le Gal, Mohamed X Ibrahim, Clotilde Wiel, Volkan I. Sayin, Murali K Akula, Christin Karlsson, Martin Dalin, Levent Akyürek, Per Lindahl, Jonas A Nilsson, Martin Bergö
Science Translational Medicine - 2015-01-01 -
Small RNA deep sequencing discriminates subsets of extracellular vesicles released by melanoma cells - evidence of unique microRNA
cargos.
Taral R Lunavat, Lesley Cheng, Dae-Kyum Kim, Joydeep Bhadury, Su Chul Jang, Cecilia Lässer, Robyn A Sharples, Marcela Davila Lopez, Jonas A Nilsson, Yong Song Gho, Andrew F Hill, Jan Lötvall
RNA biology - 2015-01-01 -
Deubiquitinase MYSM1 Regulates Innate Immunity through Inactivation of TRAF3 and TRAF6
Complexes.
Swarupa Panda, Jonas A Nilsson, Nelson O Gekara
Immunity - 2015-01-01 -
Erratum to: Isolated hepatic perfusion as a treatment for uveal melanoma liver metastases (the SCANDIUM trial): study protocol for a randomized controlled
trial.
Roger Olofsson Bagge, Lars Ny, Charlotta All-Ericsson, Malin Sternby Eilard, Magnus Rizell, Christian Cahlin, Ulrika Stierner, Ulf Lönn, Johan Hansson, Ingrid Ljuslinder, Lotta Lundgren, Gustav Ullenhag, Jens Folke Kiilgaard, Jonas A Nilsson, Per Lindnér
Trials - 2015-01-01 -
DNA Damage Primes the Type I Interferon System via the Cytosolic DNA Sensor STING to Promote Anti-Microbial Innate
Immunity.
Anetta Härtlova, Saskia F Erttmann, Faizal Am Raffi, Anja M Schmalz, Ulrike Resch, Sharath Anugula, Stefan Lienenklaus, Lisa M Nilsson, Andrea Kröger, Jonas A Nilsson, Torben Ek, Siegfried Weiss, Nelson O Gekara
Immunity - 2015-01-01 -
Antioxidants accelerate lung cancer progression in
mice.
Volkan I. Sayin, Mohamed X Ibrahim, Erik Larsson, Jonas A Nilsson, Per Lindahl, Martin Bergö
Science translational medicine - 2014-01-01 -
Isolated hepatic perfusion as a treatment for uveal melanoma liver metastases (the SCANDIUM trial): study protocol for a randomized controlled
trial.
Roger Olofsson, Lars Ny, Malin Sternby Eilard, Magnus Rizell, Christian Cahlin, Ulrika Stierner, Ulf Lönn, Johan Hansson, Ingrid Ljuslinder, Lotta Lundgren, Gustav Ullenhag, Jens Folke Kiilgaard, Jonas A Nilsson, Per Lindnér
Trials - 2014-01-01 -
Correction to bioinspired exosome-mimetic nanovesicles for targeted delivery of chemotherapeutics to malignant
tumors.
Su Chul Jang, Oh Youn Kim, Chang Min Yoon, Dong-Sic Choi, Tae-Young Roh, Jaesung Park, Jonas A Nilsson, Jan Lötvall, Yoon-Keun Kim, Yong Song Gho
ACS nano - 2014-01-01 -
Melanoma patient-derived xenografts accurately model the disease and develop fast enough to guide treatment
decisions.
Berglind Osk Einarsdottir, Roger Olofsson Bagge, Joydeep Bhadury, Henrik Jespersen, Jan Mattsson, Lisa M Nilsson, Katarina Truvé, Marcela Dávila López, Peter Naredi, Ola Nilsson, Ulrika Stierner, Lars Ny, Jonas A Nilsson
Oncotarget - 2014-01-01 -
Systematic analysis of noncoding somatic mutations and gene expression alterations across 14 tumor
types.
Nils J Fredriksson, Lars Ny, Jonas A Nilsson, Erik Larsson
Nature genetics - 2014-01-01 -
Myc-induced SUMOylation is a therapeutic vulnerability for B-cell
lymphoma.
Alexander Hoellein, Mohammad Fallahi, Stephanie Schoeffmann, Sabine Steidle, Franz X Schaub, Martina Rudelius, Iina Laitinen, Lisa M Nilsson, Andrei Goga, Christian Peschel, Jonas A Nilsson, John L Cleveland, Ulrich Keller
Blood - 2014-01-01 -
BET and HDAC inhibitors induce similar genes and biological effects and synergize to kill in Myc-induced murine
lymphoma
Joydeep Bhadury, Lisa M Nilsson, Somsundar Veppil Muralidharan, L. C. Green, Z. L. Li, E. M. Gesner, H. C. Hansen, U. B. Keller, K. G. McLure, Jonas A Nilsson
Proceedings of the National Academy of Sciences of the United States of America - 2014-01-01 -
MTH1 inhibition eradicates cancer by preventing sanitation of the dNTP
pool.
Helge Gad, Tobias Koolmeister, Ann-Sofie Jemth, Saeed Eshtad, Sylvain A Jacques, Cecilia E Ström, Linda M Svensson, Niklas Schultz, Thomas Lundbäck, Berglind Osk Einarsdottir, Aljona Saleh, Camilla Göktürk, Pawel Baranczewski, Richard Svensson, Ronnie P-A Berntsson, Robert Gustafsson, Kia Strömberg, Kumar Sanjiv, Marie-Caroline Jacques-Cordonnier, Matthieu Desroses, Anna-Lena Gustavsson, Roger Olofsson, Fredrik Johansson, Evert J Homan, Olga Loseva, Lars Bräutigam, Lars Johansson, Andreas Höglund, Anna Hagenkort, Therese Pham, Mikael Altun, Fabienne Z Gaugaz, Svante Vikingsson, Bastiaan Evers, Martin Henriksson, Karl S A Vallin, Olov A Wallner, Lars G J Hammarström, Elisee Wiita, Ingrid Almlöf, Christina Kalderén, Hanna Axelsson, Tatjana Djureinovic, Jordi Carreras Puigvert, Maria Häggblad, Fredrik Jeppsson, Ulf Martens, Cecilia Lundin, Bo Lundgren, Ingrid Granelli, Annika Jenmalm Jensen, Per Artursson, Jonas A Nilsson, Pål Stenmark, Martin Scobie, Ulrika Warpman Berglund, Thomas Helleday
Nature - 2014-01-01 -
Identification of tumorigenic and therapeutically actionable mutations in transplantable mouse tumor cells by exome
sequencing.
Joydeep Bhadury, Marcela Davila Lopez, Somsundar Veppil Muralidharan, Lisa M Nilsson, Jonas A Nilsson
Oncogenesis - 2013-01-01 -
Mouse genetics suggests cell-context dependency for Myc-regulated metabolic enzymes during
tumorigenesis.
Lisa M Nilsson, Tacha Zi Plym Forshell, Sara Rimpi, Christiane Kreutzer, Walter Pretsch, Georg W Bornkamm, Jonas A Nilsson
PLoS genetics - 2012-01-01 -
Cks1 is required for tumor cell proliferation but not sufficient to induce hematopoietic
malignancies.
Susanne Kratzat, Viktoriya Nikolova, Cornelius Miething, Alexander Hoellein, Stephanie Schoeffmann, Oliver Gorka, Elke Pietschmann, Anna-Lena Illert, Jürgen Ruland, Christian Peschel, Jonas A Nilsson, Justus Duyster, Ulrich Keller
PloS one - 2012-01-01 -
Therapeutic implications for the induced levels of Chk1 in Myc-expressing cancer
cells.
Andreas Höglund, Lisa M Nilsson, Somsundar Veppil Muralidharan, Lisa A Hasvold, Philip Merta, Martina Rudelius, Viktoriya Nikolova, Ulrich Keller, Jonas A Nilsson
Clinical cancer research : an official journal of the American Association for Cancer Research - 2011-01-01 -
Chk2 deficiency in Myc overexpressing lymphoma cells elicits a synergistic lethal response in combination with PARP
inhibition.
Andreas Höglund, Kerstin Strömvall, Yongmei Li, Linus Plym Forshell, Jonas A Nilsson
Cell cycle (Georgetown, Tex.) - 2011-01-01