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- Jennifer Uhler
Jennifer Uhler
Researcher
Department of Medical Biochemistry and Cell-
UBTD1 regulates ceramide balance and endolysosomal positioning to coordinate EGFR
signaling
S. Torrino, V. Tiroille, B. Dolfi, M. Dufies, C. Hinault, L. Bonesso, S. Dagnino, Jay (Jennifer) Uhler, M. Irondelle, A. S. Gay, L. Fleuriot, D. Debayle, S. Lacas-Gervais, M. Cormont, T. Bertero, F. Bost, J. Gilleron, S. Clavel
Elife - 2021 -
In Vitro Analysis of mtDNA
Replication
Jay (Jennifer) Uhler, Maria Falkenberg
Mitochondrial Gene Expression - 2021 -
Deep sequencing of mitochondrial DNA and characterization of a novel POLG mutation in a patient with
arPEO.
Carola Oldfors Hedberg, Bertil Macao, Swaraj Basu, Christopher Lindberg, Bradley Peter, Jay (Jennifer) Uhler, Erik Larsson, Maria Falkenberg, Anders Oldfors
Neurology. Genetics - 2020 -
Accurate mapping of mitochondrial DNA deletions and duplications using deep
sequencing
Swaraj Basu, Xie Xie, Jay (Jennifer) Uhler, Carola Oldfors Hedberg, D. Milenkovic, O. R. Baris, S. Kimoloi, S. Matic, J. B. Stewart, N. G. Larsson, R. J. Wiesner, Anders Oldfors, Claes M Gustafsson, Maria Falkenberg, Erik Larsson
PLoS Genetics - 2020 -
UBTD1 is a mechano-regulator controlling cancer
aggressiveness
S. Torrino, F. R. Roustan, L. Kaminski, T. Bertero, S. Pisano, D. Ambrosetti, M. Dufies, Jay (Jennifer) Uhler, E. Lemichez, A. Mettouchi, M. Gesson, K. Laurent, C. Gaggioli, J. F. Michiels, C. Lamaze, F. Bost, S. Clavel
Embo Reports - 2019 -
Copy-choice recombination during mitochondrial L-strand synthesis causes DNA
deletions
Örjan Persson, Yazh Muthukumar, Swaraj Basu, Louise Jenninger, Jay (Jennifer) Uhler, Anna-Karin Berglund, R. McFarland, R. W. Taylor, Claes M Gustafsson, Erik Larsson, Maria Falkenberg
Nature Communications - 2019 -
RNase H1 directs origin-specific initiation of DNA replication in human
mitochondria
Viktor Posse, Ali Al-Behadili, Jay (Jennifer) Uhler, Anders R Clausen, A. Reyes, M. Zeviani, Maria Falkenberg, Claes M Gustafsson
Plos Genetics - 2019 -
Mice lacking the mitochondrial exonuclease MGME1 accumulate mtDNA deletions without developing
progeria
S. Matic, M. Jiang, Thomas J. Nicholls, Jay (Jennifer) Uhler, C. Dirksen-Schwanenland, P. L. Polosa, M. L. Simard, X. P. Li, I. Atanassov, O. Rackham, A. Filipovska, J. B. Stewart, Maria Falkenberg, N. G. Larsson, D. Milenkovic
Nature Communications - 2018 -
Identification of a G-quadruplex forming sequence in the promoter of
UCP1
Y. B. Zhao, Jay (Jennifer) Uhler
Acta Biochimica Et Biophysica Sinica - 2018 -
MGME1 processes flaps into ligatable nicks in concert with DNA polymerase gamma during mtDNA
replication
Jay (Jennifer) Uhler, Christian Thörn, Thomas J. Nicholls, S. Matic, D. Milenkovic, Claes M Gustafsson, Maria Falkenberg
Nucleic Acids Research - 2016 -
Regulation of DNA replication at the end of the mitochondrial D-loop involves the helicase TWINKLE and a conserved sequence
element
Elisabeth Jemt, Örjan Persson, Yonghong Shi, Majda Mehmedovic, Jay (Jennifer) Uhler, Marcela Davila Lopez, C. Freyer, Claes M Gustafsson, Tore Samuelsson, Maria Falkenberg
Nucleic Acids Research - 2015 -
Primer removal during mammalian mitochondrial DNA
replication
Jay (Jennifer) Uhler, Maria Falkenberg
DNA Repair - 2015 -
The exonuclease activity of DNA polymerase gamma is required for ligation during mitochondrial DNA
replication
Bertil Macao, Jay (Jennifer) Uhler, Triinu Siibak, Xuefeng Zhu, Yonghong Shi, Wenwen Sheng, Monica Olsson, J. B. Stewart, Claes M Gustafsson, Maria Falkenberg
Nature Communications - 2015 -
The UbL protein UBTD1 stably interacts with the UBE2D family of E2 ubiquitin conjugating
enzymes
Jay (Jennifer) Uhler, H. Spahr, G. Farge, S. Clavel, N. G. Larsson, Maria Falkenberg, Tore Samuelsson, Claes M Gustafsson
Biochemical and Biophysical Research Communications - 2014 -
A hybrid G-quadruplex structure formed between RNA and DNA explains the extraordinary stability of the mitochondrial
R-loop
Paulina Wanrooij, Jay (Jennifer) Uhler, Yonghong Shi, Fredrik Westerlund, Maria Falkenberg, Claes M Gustafsson
Nucleic Acids Research - 2012 -
G-quadruplex structures in RNA stimulate mitochondrial transcription termination and primer
formation
Paulina Wanrooij, Jay (Jennifer) Uhler, Tomas Simonsson, Maria Falkenberg, Claes M Gustafsson
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA - 2010 -
Reversal of RNA polymerase II ubiquitylation by the ubiquitin protease
Ubp3.
Kristian Kvint, Jay (Jennifer) Uhler, Michael J Taschner, Stefan Sigurdsson, Hediye Erdjument-Bromage, Paul Tempst, Jesper Q Svejstrup
Molecular cell - 2008