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- Louise Jenninger
Louise Jenninger
Biomedical Scientist
Department of Medical Biochemistry and Cell biology-
Modelling POLG mutations in mice unravels a critical role of POLγΒ in regulating phenotypic
severity
Samantha Corra, Alessandro Zuppardo, Sebastian Valenzuela, Louise Jenninger, Raffaele Cerutti, Sirelin Sillamaa, Emily Hoberg, Katarina Johansson, Urska Rovsnik, Sara Volta, Pedro Silva-Pinheiro, Hannah Davis, Aleksandra Trifunovic, Michal Minczuk, Claes M Gustafsson, Anu Suomalainen, Massimo Zeviani, Bertil Macao, Xuefeng Zhu, Maria Falkenberg, Carlo Viscomi
NATURE COMMUNICATIONS - 2025 -
Small molecules restore mutant mitochondrial DNA polymerase
activity
Sebastian Valenzuela, Xuefeng Zhu, Bertil Macao, Mattias Stamgren, Carol Geukens, Paul S. Charifson, Gunther Kern, Emily Hoberg, Louise Jenninger, Anja V. Gruszczyk, Seoeun Lee, Katarina Johansson, Javier Miralles Fuste, Yonghong Shi, S. Jordan Kerns, Laleh Arabanian, Gabriel Martinez Botella, Sofie Ekstroem, Jeremy Green, Andrew M. Griffin, Carlos Pardo-Hernandez, Thomas A. Keating, Barbara Kuppers-Munther, Nils-Goran Larsson, Cindy Phan, Viktor Posse, Juli E. Jones, Xie Xie, Simon Giroux, Claes M Gustafsson, Maria Falkenberg
NATURE - 2025 -
NUDT6 and NUDT9, two mitochondrial members of the NUDIX family, have distinct hydrolysis
activities
L. Debar, Layal Ishak, A. Moretton, S. Anoosheh, F. Morel, Louise Jenninger, I. Garreau-Balandier, P. Vernet, A. Hofer, S. van den Wildenberg, G. Farge
Mitochondrion - 2023 -
Mammalian RNase H1 directs RNA primer formation for mtDNA replication initiation and is also necessary for mtDNA replication
completion
J. Misic, D. Milenkovic, Ali Al-Behadili, Xie Xie, M. Jiang, S. Jiang, R. Filograna, C. Koolmeister, S. J. Siira, Louise Jenninger, A. Filipovska, Anders R Clausen, L. Caporali, M. L. Valentino, C. La Morgia, V. Carelli, T. J. Nicholls, A. Wredenberg, Maria Falkenberg, N. G. Larsson
Nucleic Acids Research - 2022 -
The mitochondrial single-stranded DNA binding protein is essential for initiation of mtDNA
replication
M. Jiang, Xie Xie, Xuefeng Zhu, S. Jiang, D. Milenkovic, J. Misic, Yonghong Shi, N. Tandukar, X. Li, I. Atanassov, Louise Jenninger, Emily Hoberg, S. Albarran-Gutierrez, Zsolt Szilagyi, Bertil Macao, S. J. Siira, V. Carelli, J. D. Griffith, Claes M Gustafsson, T. J. Nicholls, A. Filipovska, N. G. Larsson, Maria Falkenberg
Science Advances - 2021 -
A unique arginine cluster in PolDIP2 enhances nucleotide binding and DNA synthesis by
PrimPol
K. Kasho, G. Stojkovič, C. Velázquez-Ruiz, M. I. Martínez-Jiménez, M. Doimo, T. Laurent, A. Berner, A. E. Pérez-Rivera, Louise Jenninger, L. Blanco, S. Wanrooij
Nucleic acids research - 2021 -
Copy-choice recombination during mitochondrial L-strand synthesis causes DNA
deletions
Örjan Persson, Yazh Muthukumar, Swaraj Basu, Louise Jenninger, Jay (Jennifer) Uhler, Anna-Karin Berglund, R. McFarland, R. W. Taylor, Claes M Gustafsson, Erik Larsson, Maria Falkenberg
Nature Communications - 2019