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Susanne Fransson
Researcher
Department of Laboratory MedicineAdjunct Senior Lecturer
Department of Laboratory Medicine-
DNA methylation profiling for molecular classification of
neuroblastoma
Maja Löfgren, Anna Djos, Shiva Rezaei, Medha Suman, Per Kogner, Tommy Martinsson, Susanne Fransson, Helena Carén
CLINICAL EPIGENETICS - 2025 -
Comparative analysis of whole-genome sequencing of tumor and cfDNA in a neuroblastoma patient: a case
report
Susanne Fransson, Kleopatra Georgantzi, Anna Djos, Jennie Gaarder, Johanna Svensson, Vimala Anthonydhason, Per Kogner, Tommy Martinsson, Ganesh Umapathy
FRONTIERS IN ONCOLOGY - 2025 -
Gain of chromosome 17 is an early genetic abnormality in neuroblastoma with PPM1D emerging as a strong candidate oncogene driving tumor
progression
Jelena Milosevic, Susanne Fransson, Johanna Svensson, Jorg Otte, Thale K. Olsen, Baldur Sveinbjornsson, Falk Hertwig, Christoph Bartenhagen, Frida Abel, Susanne E Reinsbach, Anna Djos, Niloufar Javanmardi, Yao Shi, Jane Y. Hehir-Kwa, Arjen Mensenkamp, Godelieve AM. Tytgat, Johan Holmberg, Jan J. Molenaar, Marjolijn Jongmans, Matthias Fischer, Ninib Baryawno, David Gisselsson, Tommy Martinsson, Per Kogner, John Inge Johnsen
CANCER LETTERS - 2025 -
Altered methylation of imprinted genes in neuroblastoma: implications for prognostic
refinement
Medha Suman, Maja Löfgren, Susanne Fransson, Jewahri Idris Yousuf, Johanna Svensson, Anna Djos, Tommy Martinsson, Per Kogner, Teresia Kling, Helena Carén
JOURNAL OF TRANSLATIONAL MEDICINE - 2024 -
Loss of Chromosome Y in Neuroblastoma Is Associated With High-Risk Disease, 11q-Deletion, and Telomere
Maintenance
Anna Djos, Johanna Svensson, Jennie Gaarder, Ganesh Umapathy, Staffan Nilsson, Torben Ek, Hartmut Vogt, Kleopatra Georgantzi, Ingrid Ora, Catarina Trager, Per Kogner, Tommy Martinsson, Susanne Fransson
Genes, Chromosomes and Cancer - 2024 -
Long-Lasting Response to Lorlatinib in Patients with ALK-Driven Relapsed or Refractory Neuroblastoma Monitored with Circulating Tumor DNA
Analysis
Torben Ek, Raghda Ragab Mohamed Hassan Ahmed Ibrahim, Hartmut Vogt, Kleopatra Georgantzi, Catarina Trager, Jennie Gaarder, Anna Djos, Ida Rahmqvist, Elisabeth Mellström, Fani Pujol-Calderón, Christoffer Vannas, Lina Hansson, Henrik Fagman, Diana Treis, Susanne Fransson, Tobias Österlund, Tzu-Po Chuang, Bronte Manouk Verhoeven, Anders Ståhlberg, Ruth H. Palmer, Bengt Hallberg, Tommy Martinsson, Per Kogner, Martin Dalin
Cancer Research Communications - 2024 -
Heterogeneous SSTR2 target expression and a novel KIAA1549::BRAF fusion clone in a progressive metastatic lesion following 177Lutetium-DOTATATE molecular radiotherapy in neuroblastoma: a case
report
Se Whee Sammy Park, Susanne Fransson, Fredrik Sundquist, Joachim N. Nilsson, Per Gryback, Sandra Wessman, Jacob Stromgren, Anna Djos, Henrik Fagman, Helene Sjoegren, Kleopatra Georgantzi, Nikolas Herold, Per Kogner, Dan Granberg, Mark N. Gaze, Tommy Martinsson, Kasper Karlsson, Jakob J. E. Stenman
FRONTIERS IN ONCOLOGY - 2024 -
Joint single-cell genetic and transcriptomic analysis reveal pre-malignant SCP-like subclones in human
neuroblastoma
Thale K. Olsen, Jorg Otte, Shenglin Mei, Bethel Tesfai Embaie, Polina Kameneva, Huaitao Cheng, Teng Gao, Vasilios Zachariadis, Ioanna Tsea, Asa Bjorklund, Emil Kryukov, Ziyi Hou, Anna Johansson, Erik Sundstrom, Tommy Martinsson, Susanne Fransson, Jakob Stenman, Shahrzad Shirazi Fard, John Inge Johnsen, Per Kogner, Igor Adameyko, Martin Enge, Peter V. Kharchenko, Ninib Baryawno
MOLECULAR CANCER - 2024 -
METTL3 drives telomere targeting of TERRA lncRNA through m6A-dependent R-loop formation: a therapeutic target for ALT-positive
neuroblastoma
Roshan Vaid, Ketan Thombare, Akram Mendez, Rebeca Burgos-Panadero, Anna Djos, Daniel Jachimowicz, Kristina Ihrmark Lundberg, Christoph Bartenhagen, Navinder Kumar, Conny Tummler, Carina Sihlbom, Susanne Fransson, John Inge Johnsen, Per Kogner, Tommy Martinsson, Matthias Fischer, Tanmoy Mondal
NUCLEIC ACIDS RESEARCH - 2024 -
Diagnostic Yield From a Nationwide Implementation of Precision Medicine for all Children With
Cancer.
Elisabeth Wadensten, Sandra Wessman, Frida Abel, Teresita Diaz De Ståhl, Bianca Tesi, Christina Orsmark Pietras, Linda Arvidsson, Fulya Taylan, Susanne Fransson, Hartmut Vogt, Anna Poluha, Sailendra Pradhananga, Maria Hellberg, Kristina Lagerstedt-Robinson, Praveen Raj Somarajan, Sofie Samuelsson, Sara Orrsjö, Khurram Maqbool, Karin Henning, Tobias Strid, Torben Ek, Henrik Fagman, Thomas Olsson Bontell, Tommy Martinsson, Florian Puls, Per Kogner, Valtteri Wirta, Cornelis Jan Pronk, Joakim Wille, Richard Rosenquist, Monica Nistér, Fredrik Mertens, Magnus Sabel, Ulrika Norén-Nyström, Pernilla Grillner, Ann Nordgren, Gustaf Ljungman, Johanna Sandgren, David Gisselsson
JCO Precision Oncology (JCO PO) - 2023 -
Telomere Maintenance Mechanisms in a Cohort of High-Risk Neuroblastoma Tumors and Its Relation to Genomic Variants in the TERT and ATRX
Genes
Anna Djos, Ketan Thombare, Roshan Vaid, Jennie Gaarder, Ganesh Umapathy, Susanne E Reinsbach, Kleopatra Georgantzi, Jakob Stenman, Helena Carén, Torben Ek, Tanmoy Mondal, Per Kogner, Tommy Martinsson, Susanne Fransson
CANCERS - 2023 -
Identification of recurrent 3q13.31 chromosomal rearrangement indicates LSAMP as a tumor suppressor gene in
neuroblastoma
Angela Martinez-Monleon, Jostein Gaarder, Anna Djos, P. Kogner, Susanne Fransson
International Journal of Oncology - 2023 -
Novel human-derived EML4-ALK fusion cell lines identify ribonucleotide reductase RRM2 as a target of activated ALK in
NSCLC
Abdulmalik Bokhari, Wei-Yun Lai, A. T. Le, Jonatan L. Gabre, Tzu-Po Chuang, Susanne Fransson, B. Bergman, Anna Djos, N. Chen, Tommy Martinsson, J. Van den Eynden, R. C. Doebele, Ruth H. Palmer, Bengt Hallberg, Ganesh Umapathy
Lung Cancer - 2022 -
Whole exome sequencing identifies KIF26B, LIFR and LAMC1 mutations in familial vesicoureteral
reflux
Zsuzsa Bartik, Ulla Sillén, Anna Djos, A. Lindholm, Susanne Fransson
Plos One - 2022 -
Multifocal Neuroblastoma and Central Hypoventilation in An Infant with Germline ALK F1174I
Mutation
Anna Djos, D. Treis, Susanne Fransson, L. G. Murkes, S. Wessman, J. Asmundsson, A. Markstrom, P. Kogner, Tommy Martinsson
Diagnostics - 2022 -
Amplification of CDK4 and MDM2: a detailed study of a high-risk neuroblastoma
subgroup
Angela Martinez-Monleon, Hanna Kryh Öberg, Jostein Gaarder, A. P. Berbegall, Niloufar Javanmardi, Anna Djos, M. Ussowicz, S. Taschner-Mandl, I. M. Ambros, I. Ora, B. Sandstedt, K. Beiske, R. Ladenstein, R. Noguera, P. F. Ambros, L. G. Murkes, G. Ljungman, P. Kogner, Susanne Fransson, Tommy Martinsson
Scientific Reports - 2022 -
Sustained Response to Entrectinib in an Infant With a Germline ALKAL2 Variant and Refractory Metastatic Neuroblastoma With Chromosomal 2p Gain and Anaplastic Lymphoma Kinase and Tropomyosin Receptor Kinase
Activation
D. Treis, Ganesh Umapathy, Susanne Fransson, Jikui Guan, Patricia Mendoza-García, Joachim T. Siaw, S. Wessman, L. G. Murkes, J. J. E. Stenman, Anna Djos, L. H. M. Elfman, J. I. Johnsen, Bengt Hallberg, Ruth H. Palmer, Tommy Martinsson, P. Kogner
JCO Precision Oncology - 2022 -
TC-hunter: identification of the insertion site of a transgenic gene within the host
genome
Vanja Börjesson , Angela Martinez-Monleon, Susanne Fransson, P. Kogner, J. I. Johnsen, J. Milosevic, Marcela Davila Lopez
Bmc Genomics - 2022 -
A genome-wide scan to locate regions associated with familial vesicoureteral
reflux
Zsuzsa Bartik, Ulla Sillén, Malin Östensson, Susanne Fransson, Anna Djos, Rose-Marie Sjöberg, Tommy Martinsson
Experimental and Therapeutic Medicine - 2022 -
ALK ligand ALKAL2 potentiates MYCN-driven neuroblastoma in the absence of ALK
mutation.
Marcus Borenäs, Ganesh Umapathy, Wei-Yun Lai, Dan E. Lind, Barbara Witek, Jikui Guan, Patricia Mendoza-García, Tafheem Masudi, Arne Claeys, Tzu-Po Chuang, Abeer El Wakil, Badrul Arefin, Susanne Fransson, Jan Koster, Mathias Johansson, Jennie Gaarder, Jimmy Van den Eynden, Bengt Hallberg, Ruth H. Palmer
The EMBO journal - 2021 -
PPM1D Is a Therapeutic Target in Childhood Neural
Tumors.
Jelena Milosevic, Diana Treis, Susanne Fransson, Gabriel Gallo-Oller, Baldur Sveinbjörnsson, Nina Eissler, Keiji Tanino, Kazuyasu Sakaguchi, Tommy Martinsson, Malin Wickström, Per Kogner, John Inge Johnsen
Cancers - 2021 -
High Expression of PPM1D Induces Tumors Phenotypically Similar to TP53 Loss-of-Function Mutations in
Mice.
Jelena Milosevic, Susanne Fransson, Miklos Gulyas, Thale K Olsen, Gabriel Gallo-Oller, Diana Treis, Lotta H M Elfman, Margareta Wilhelm, Tommy Martinsson, Ninib Baryawno, Per Kogner, John Inge Johnsen
Cancers - 2021 -
Whole-genome sequencing of recurrent neuroblastoma reveals somatic mutations that affect key players in cancer progression and telomere
maintenance
Susanne Fransson, Angela Martinez-Monleon, M. Johansson, Rose-Marie Sjöberg, C. Bjorklund, G. Ljungman, E. K. Torben, P. Kogner, Tommy Martinsson
Scientific Reports - 2020 -
11q Deletion or ALK Activity Curbs DLG2 Expression to Maintain an Undifferentiated State in
Neuroblastoma
Joachim T. Siaw, Niloufar Javanmardi, Jimmy Van den Eynden, Dan E. Lind, Susanne Fransson, Angela Martinez-Monleon, Anna Djos, Rose-Marie Sjöberg, Malin Östensson, H. Caren, G. Troen, K. Beiske, A. P. Berbegall, R. Noguera, Wei-Yun Lai, P. Kogner, Ruth H. Palmer, Bengt Hallberg, Tommy Martinsson
Cell Reports - 2020 -
Analysis of ALK, MYCN, and the ALK ligand ALKAL2 (FAM150B/AUG alpha) in neuroblastoma patient samples with chromosome arm 2p
rearrangements
Niloufar Javanmardi, Susanne Fransson, Anna Djos, Ganesh Umapathy, Malin Östensson, J. Milosevic, Marcus Borenäs, Bengt Hallberg, P. Kogner, Tommy Martinsson, Ruth H. Palmer
Genes Chromosomes & Cancer - 2020 -
Low Frequency ALK Hotspots Mutations In Neuroblastoma Tumours Detected By Ultra-deep Sequencing: Implications For ALK Inhibitor
Treatment
Niloufar Javanmardi, Susanne Fransson, Anna Djos, Rose-Marie Sjöberg, Staffan Nilsson, Katarina Truvé, P. Kogner, Tommy Martinsson
Scientific Reports - 2019 -
Familial intestinal degenerative neuropathy with chronic intestinal pseudo-obstruction linked to a gene locus with duplication in chromosome
9
Hasse Abrahamsson, Frida Ahlfors, Susanne Fransson, Staffan Nilsson, H. Linander, Tommy Martinsson
Scandinavian Journal of Gastroenterology - 2019 -
Patient-Derived Xenograft Models Reveal Intratumor Heterogeneity and Temporal Stability in
Neuroblastoma
N. Braekeveldt, K. von Stedingk, Susanne Fransson, Angela Martinez-Monleon, D. Lindgren, H. Axelson, F. Levander, J. Willforss, K. Hansson, I. Ora, T. Backman, A. Borjesson, S. Beckman, J. Esfandyari, A. P. Berbegall, R. Noguera, J. Karlsson, J. Koster, Tommy Martinsson, D. Gisselsson, S. Pahlman, D. Bexell
Cancer Research - 2018 -
Clinical response of the novel activating ALK-I1171T mutation in neuroblastoma to the ALK inhibitor
ceritinib.
Jikui Guan, Susanne Fransson, Joachim T. Siaw, Diana Treis, Jimmy Van den Eynden, Damini Chand, Ganesh Umapathy, Kristina Ruuth, Alia Shamikh, Hans Jacobsson, Lena Gordon, Par-Johan Svensson, Magnus Hansson, Tommy Martinsson, Per Kogner, Ruth H. Palmer, Bengt Hallberg
Cold Spring Harbor molecular case studies - 2018 -
Rho-associated kinase is a therapeutic target in
neuroblastoma
C. Dyberg, Susanne Fransson, T. Andonova, B. Sveinbjornsson, J. Lannerholm-Palm, T. K. Olsen, D. Forsberg, E. Herlenius, Tommy Martinsson, B. Brodin, P. Kogner, J. I. Johnsen, M. Wickstrom
Proceedings of the National Academy of Sciences of the United States of America - 2017 -
Estimation of copy number aberrations: Comparison of exome sequencing data with SNP microarrays identifies homozygous deletions of 19q13.2 and iin
neuroblastoma
Susanne Fransson, Malin Östensson, Anna Djos, Niloufar Javanmardi, P. Kogner, Tommy Martinsson
International Journal of Oncology - 2016 -
Intragenic anaplastic lymphoma kinase (ALK) rearrangements: Translocations as a novel mechanism of ALK activation in neuroblastoma
tumors.
Susanne Fransson, Magnus Hansson, Kristina Ruuth, Anna Djos, Ana Berbegall, Niloufar Javanmardi, Jonas Abrahamsson, Ruth H. Palmer, Rosa Noguera, Bengt Hallberg, Per Kogner, Tommy Martinsson
Genes, chromosomes & cancer - 2015 -
The risk-associated long noncoding RNA NBAT-1 controls neuroblastoma progression by regulating cell proliferation and neuronal
differentiation.
Gaurav Kumar Pandey, Sanhita Mitra, Santhilal Subhash, Falk Hertwig, Meena Kanduri, Kankadeb Mishra, Susanne Fransson, Abiarchana Ganeshram, Tanmoy Mondal, Sashidar Bandaru, Malin Östensson, Levent Akyürek, Jonas Abrahamsson, Susan Pfeifer, Erik Larsson, Leming Shi, Zhiyu Peng, Matthias Fischer, Tommy Martinsson, Fredrik Hedborg, Per Kogner, Chandrasekhar Kanduri
Cancer Cell - 2014 -
High level of p37δ-mRNA relative to p110δ-mRNA in neuroblastoma tumors correlates with poor patient
survival.
Susanne Fransson, Katarina Ejeskär
Medical oncology (Northwood, London, England) - 2013 -
Aneuploidy in neuroblastoma tumors is not associated with inactivating point mutations in the STAG2
gene.
Anna Djos, Susanne Fransson, Per Kogner, Tommy Martinsson
BMC medical genetics - 2013 -
Aggressive neuroblastomas have high p110alpha but low p110delta and p55alpha/p50alpha protein levels compared to low stage
neuroblastomas.
Susanne Fransson, Per Kogner, Tommy Martinsson, Katarina Ejeskär
Journal of molecular signaling - 2013 -
p37δ is a new isoform of PI3K p110δ that increases cell proliferation and is overexpressed in
tumors.
Susanne Fransson, Anne Uv, Henry Eriksson, Mattias K Andersson, Yvonne Wettergren, Martin Bergö, Katarina Ejeskär
Oncogene - 2012 -
From 1p3 to PI3K - Studies of
neuroblastoma
Susanne Fransson
2011 -
Genetic and epigenetic changes in the common 1p36 deletion in neuroblastoma
tumours.
Helena Carén, Susanne Fransson, Katarina Ejeskär, Per Kogner, Tommy Martinsson
British Journal of Cancer - 2007 -
Neuroblastoma tumors with favorable and unfavorable outcomes: Significant differences in mRNA expression of genes mapped at
1p36.2.
Susanne Fransson, Tommy Martinsson, Katarina Ejeskär
Genes, chromosomes & cancer - 2007 -
An alternative splice variant of PIK3CD is common in neuroblastoma, colorectal and ovarian
cancer.
Katarina Ejeskär, Susanne Fransson
ECCO-14, Barcelona, Spain, 2007 - 2007 -
Significant Decrease in mRNA Expression of Five Genes Mapped at 1p36.2, comparing Favorable and Unfavorable
Neuroblastomas.
Susanne Fransson, Cecilia Krona, Rose-Marie Sjöberg, Frida Abel, Tommy Martinsson, Katarina Ejeskär
Advances in Neuroblastoma Research 2006, Los Angeles, USA, 2006 - 2006 -
In vitro-Transcribed mRNA from Five Genes from the 1p36.2-region have Tumor Suppressor Properties when Transfected into Neuroblastoma
Cells.
Katarina Ejeskär, Susanne Fransson, Panayiotis A Ioannou
Advances in Neuroblastoma Research 2006, Los Angeles, USA, 2006 - 2006 -
Method for efficient transfection of in vitro-transcribed mRNA into SK-N-AS and HEK293 cells: difference in the toxicity of nuclear EGFP compared to cytoplasmic
EGFP.
Katarina Ejeskär, Susanne Fransson, Faten Zaibak, Panayiotis A Ioannou
International journal of molecular medicine - 2006 -
A cluster of genes located in 1p36 are down-regulated in neuroblastomas with poor prognosis, but not due to CpG island
methylation.
Helena Carén, Katarina Ejeskär, Susanne Fransson, Luke Hesson, Farida Latif, Rose-Marie Sjöberg, Cecilia Krona, Tommy Martinsson
Molecular cancer - 2005 -
Transfection on in vitro-transcribed EGFP-mRNA into SK-N-AS and 293 cells shows major difference in the sensitivity to a nuclear compared to a cytoplasmic
EGFP-variant.
Katarina Ejeskär, Susanne Fransson, Faten Zaibak, Panayiotis A Ioannou
American Society of Human Genetics, Salt Lake City, USA, 2005 - 2005 -
Transfection of in vitro-transcribed EGFP-mRNA from the 1p36 region into SK-N-AS and 293
cells.
Katarina Ejeskär, Susanne Fransson, Faten Zaibak, Panayiotis A Ioannou
9th Cancer Genetics Course, Bertinoro, Italy 2005 - 2005