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Toshima Parris
Researcher
Department of OncologyAbout Toshima Parris
Research area: Translational research on the development of novel treatment options for breast- and ovarian cancer.
Research environment Toshima Parris works in a multidisciplinary research group comprised of several biologists (molecular biologist/geneticist), specialists in oncology, pathology, surgery, and radiation physics, as well as, one PhD student and a Masters student. Her research is conducted at the Department of Oncology and Sahlgrenska Center for Cancer Research.
Background The main objective of this proposal is to discover new treatment options for triple-negative breast cancer (TNBC) that prevent recurrence and metastasis. In 2018, approximately 2.1 million new breast cancer cases were reported worldwide. TNBC accounts for about 15-20% of these cases and is an aggressive form of breast cancer (grows rapidly and tends to metastasize) frequently found in women under the age of 50. Due to resistance to most common breast cancer treatments, battling TNBC has proven difficult. About 30% of TNBCs will recur within the first three years after initial diagnosis and 5-year survival rates are drastically lower (77%) than other types of breast cancer (93%). We propose a strategy to test combination therapies on TNBCs in vitro and in vivo. If successful, my work may not only pinpoint promising treatment strategies that can be used for future testing in clinical trials, but also identify genes that play a pivotal role in response/resistance to certain treatment options. These genes, in turn, may be used as diagnostic tools to identify patients that would most benefit from a specific type of treatment.
Research tools and resources
- In vitro studies: Cell lines, spheroids, patient-derived organoids, drug screening
- Biobanking of patient samples
- Flow cytometry, immunohistochemistry, tissue microarrays (TMA), RNA-seq, DNA methylation profiling, Immunoblot, quantitative real-time PCR (qPCR), and fluorescence in situ hybridization (FISH)
- Bioinformatics analyses of pan-cancer data: RNA-seq, mutation signatures, DNA copy number profiling, drug sensitivity data
- Drug repurposing: Transcriptomics- and structure-based virtual screening
- Epidemiologic studies using national registers: Swedish National Register for Breast Cancer (NBCR), National Patient Register, and Swedish Cause of Death Register
Current group members
- Maxim Olsson, PhD student
- Slavica Janeva, Postdoc
- Jenny Nyqvist-Streng, Postdoc
- Sithumini Sarathchandra, Master's student
Financial support
- King Gustav V Jubilee Clinic Research Foundation
- Familjen Knut och Ragnvi Jacobsson
- Assar Gabrielsson Research Foundation for Clinical Cancer Research
- Sahlgrenska University Hospital Research Foundation
- Magnus Bergvall Research Foundation
- Wilhelm och Martina Lundgren Research Foundation
- Åke Wiberg Research Foundation
- The Swedish Society of Medicine
- Anna-Lisa och Bror Björnsson Research Foundation
- Cancer and Allergy Research Foundation
Awards
- Top 100 cancer (#4) Scientific Reports papers in 2020, https://doi.org/10.1038/s41598-020-62848-5.
Professional organizations
- The European Association for Cancer Research (EACR)
- Swedish Association of Scientists (Naturvetarna)
- Swedish Association of Scientists at the University of Gothenburg (Naturvetarna vid GU)
- Swedish Society of Medicine (Svenska Läkaresällskapet)
- Radiation Research Society (RADRES)
- American Association of Cancer Research (AACR)
Associate Editor
- BMC Cancer, Journal of Ovarian Research, Frontiers in Medicine, Frontiers in Genetics (Cancer Genetics and Oncogenomics), Frontiers in Oncology (Breast Cancer)
Popular science articles
- Parris TZ. Bröstcancerpatientens tumör innehåller prognostisk information. Onkologi i Sverige 02-2014, 72-78.
-
Lemur tail kinase 3 serves as a predictor of patient outcomes and a target for the treatment of ovarian
cancer
Ghassan M. Saed, Nicole M. Fletcher, Harvey Sharma, Axel Stenmark Tullberg, Ella Ittner, Toshima Z Parris, Daniella Pettersson, Aniko Kovacs, Elisabeth Werner Rönnerman, Pernilla Dahm-Kähler, Anna Portela, Pamela D. Garzone, Robert Morris, Khalil Helou
MOLECULAR THERAPY ONCOLOGY - 2024 -
Multi-omics analysis identifies repurposing bortezomib in the treatment of kidney-, nervous system-, and hematological
cancers
Peter Larsson, Maxim Olsson, Sithumini Sarathchandra, Anna Fäldt Beding, Eva Forssell-Aronsson, Anikó Kovács, Per Karlsson, Khalil Helou, Toshima Z Parris
Scientific Reports - 2024 -
Effects of recombinant α1-microglobulin on early proteomic response in risk organs after exposure to
177Lu-octreotate
Charlotte Ytterbrink, Emman Shubbar, Toshima Z Parris, Britta Langen, Malin Druid, Emil Schüler, Sven Erik Strand, Bo Åkerström, Magnus Gram, Khalil Helou, Eva Forssell-Aronsson
International Journal of Molecular Sciences - 2024 -
Digital RNA sequencing using unique molecular identifiers enables ultrasensitive RNA mutation
analysis
Manuel Luna Santa-María, Daniel Andersson, Toshima Z Parris, Khalil Helou, Tobias Österlund, Anders Ståhlberg
COMMUNICATIONS BIOLOGY - 2024 -
Integrated transcriptomics- and structure-based drug repositioning identifies drugs with proteasome inhibitor
properties
Peter Larsson, MC Rosa, Benedetta Righino, Maxim Olsson, Bogdan Iulius Florea, Eva Forssell-Aronsson, Anikó Kovács, Per Karlsson, Khalil Helou, Toshima Z Parris
Scientific Reports - 2024 -
Late age- and dose-related effects on the proteome of thyroid tissue in rats after 131I
exposure.
Malin Druid, Emman Shubbar, Johan Spetz, Toshima Z Parris, Britta Langen, Charlotte Ytterbrink, Evelin Berger, Khalil Helou, Eva Forssell-Aronsson
Radiation - 2024 -
Repurposing proteasome inhibitors for improved treatment of triple-negative breast
cancer
Peter Larsson, Daniella Pettersson, Maxim Olsson, Sithumini Sarathchandra, Alexandra Abramsson, Henrik Zetterberg, Ella Ittner, Eva Forssell-Aronsson, Anikó Kovács, Per Karlsson, Khalil Helou, Toshima Z Parris
Cell death discovery - 2024 -
Clinical relevance of biomarker discordance between primary breast cancers and synchronous axillary lymph node
metastases.
Slavica Janeva, Toshima Z Parris, Ellen Krabbe, Marie Sundquist, Per Karlsson, Riccardo A Audisio, Roger Olofsson, Anikó Kovács
Clinical & experimental metastasis - 2023 -
Cancer stem cells are prevalent in the basal-like 2 and mesenchymal triple-negative breast cancer subtypes in
vitro
Maxim Olsson, Peter Larsson, Junko Johansson, Vasu R. Sah, Toshima Z Parris
Frontiers in Cell and Developmental Biology - 2023 -
Clinical evaluation of molecular surrogate subtypes in patients with ipsilateral multifocal primary breast
cancer
Slavica Janeva, E. Krabbe, Toshima Z Parris, Salmir Nasic, M. Sundquist, Per Karlsson, Riccardo A Audisio, Roger Olofsson Bagge, Anikó Kovács
Breast Cancer Research - 2023 -
Optimization of Cell Viability Assays for Drug Sensitivity
Screens.
Peter Larsson, Toshima Z Parris
Methods in molecular biology (Clifton, N.J.) Vol. 2644 - 2023 -
Age-related long-term response in rat thyroid tissue and plasma after internal low dose exposure to
I-131
Malin Larsson, Nils Rudqvist, Johan Spetz, Toshima Z Parris, Britta Langen, Khalil Helou, Eva Forssell-Aronsson
Scientific Reports - 2022 -
Pan-cancer analysis of genomic and transcriptomic data reveals the prognostic relevance of human proteasome genes in different cancer
types.
Peter Larsson, Daniella Pettersson, Hanna Engqvist, Elisabeth Werner Rönnerman, Eva Forssell-Aronsson, Anikó Kovács, Per Karlsson, Khalil Helou, Toshima Z Parris
BMC cancer - 2022 -
Trefoil factor family proteins as potential diagnostic markers for mucinous invasive ovarian
carcinoma.
Elisabeth Werner Rönnerman, Daniella Pettersson, Szilard Nemes, Pernilla Dahm-Kähler, Anikó Kovács, Per Karlsson, Toshima Z Parris, Khalil Helou
Frontiers in oncology - 2022 -
Pan-cancer analysis identifies BIRC5 as a prognostic
biomarker.
Anna Fäldt Beding, Peter Larsson, Khalil Helou, Zakaria Einbeigi, Toshima Z Parris
BMC Cancer - 2022 -
Comparison of breast cancer surrogate subtyping using a closed-system RT-qPCR breast cancer assay and immunohistochemistry on 100 core needle biopsies with matching surgical
specimens.
Slavica Janeva, Toshima Z Parris, Salmir Nasic, Shahin De Lara, Karolina Larsson, Riccardo A Audisio, Roger Olofsson, Anikó Kovács
BMC Cancer - 2021 -
Prognostic Significance of BIRC5/Survivin in Breast Cancer: Results from Three Independent
Cohorts.
Nina Oparina, Malin Erlandsson, Anna Fäldt Beding, Toshima Z Parris, Khalil Helou, Per Karlsson, Zakaria Einbeigi, Maria Bokarewa
Cancers - 2021 -
Genetic alterations associated with multiple primary
malignancies.
Jenny Nyqvist, Anikó Kovács, Zakaria Einbeigi, Per Karlsson, Eva Forssell-Aronsson, Khalil Helou, Toshima Z Parris
Cancer medicine - 2021 -
Long-term transcriptomic and proteomic effects in Sprague Dawley rat thyroid and plasma after internal low dose 131I
exposure.
Malin Larsson, Nils Rudqvist, Johan Spetz, Emman Shubbar, Toshima Z Parris, Britta Langen, Khalil Helou, Eva Forssell-Aronsson
PloS one - 2020 -
Adjuvant chemotherapy and survival in women aged 70 years and older with triple-negative breast cancer: a Swedish population-based propensity score-matched
analysis
Slavica Janeva, Chenyang Zhang, Anikó Kovács, Toshima Z Parris, Jennifer A. Crozier, Christopher M. Pezzi, Barbro Linderholm, Riccardo A Audisio, Roger Olofsson Bagge
The Lancet Healthy Longevity - 2020 -
Integrative genomics approach identifies molecular features associated with early-stage ovarian carcinoma
histotypes.
Hanna Engqvist, Toshima Z Parris, Jana Biermann, Elisabeth Werner Rönnerman, Peter Larsson, Karin Sundfeldt, Anikó Kovács, Per Karlsson, Khalil Helou
Scientific reports - 2020 -
Optimization of cell viability assays to improve replicability and reproducibility of cancer drug sensitivity
screens.
Peter Larsson, Hanna Engqvist, Jana Biermann, Elisabeth Werner Rönnerman, Eva Forssell-Aronsson, Anikó Kovács, Per Karlsson, Khalil Helou, Toshima Z Parris
Scientific Reports - 2020 -
A 17-marker panel for global genomic instability in breast
cancer.
Jana Biermann, Szilárd Nemes, Toshima Z Parris, Hanna Engqvist, Elisabeth Werner Rönnerman, Anikó Kovács, Per Karlsson, Khalil Helou
Genomics - 2020 -
Male Breast Carcinoma after Irradiation and Long-Term Phenothiazine Exposure: A Case
Report
Ragnar Hultborn, Toshima Z Parris, Khalil Helou, Åke Borg, Shahin De Lara
Case Reports in Oncology - 2020 -
Previously diagnosed multiple primary malignancies in patients with breast carcinoma in Western Sweden between 2007 and
2018.
Jenny Nyqvist, Toshima Z Parris, Khalil Helou, Elisabeth Kenne Sarenmalm, Zakaria Einbeigi, Per Karlsson, Salmir Nasic, Anikó Kovács
Breast cancer research and treatment - 2020 -
Pan-cancer analyses of human nuclear receptors reveal transcriptome diversity and prognostic value across cancer
types
Toshima Z Parris
Scientific Reports - 2020 -
Identification of candidate genetic variants and altered protein expression in neural stem and mature neural cells support altered microtubule function to be an essential component in bipolar
disorder
Katarina Truvé, Toshima Z Parris, Dzeneta Vizlin-Hodzic, Susanne Salmela, Evelin Berger, Hans Ågren, Keiko Funa
Translational Psychiatry - 2020 -
Proteomic expression analysis of rat thyroid tissue 12 months after low-intermediate 131I
exposure
Malin Larsson, Emman Shubbar, Johan Spetz, Britta Langen, Toshima Z Parris, Khalil Helou, Eva Forssell-Aronsson
ERRS 2020 - 2020 -
Breast Implant-Associated Anaplastic Large Cell Lymphoma (BIA-ALCL) - Case
Report
Slavica Janeva, Ulrika Hansson, Susanne Bram Ednersson, Balázs Márton, Khalil Helou, Toshima Z Parris, Håkan Hallberg, Anikó Kovács
Annals of Clinical and Medical Case Reports - 2020 -
Immunohistochemical validation of COL3A1, GPR158 and PITHD1 as prognostic biomarkers in early-stage ovarian
carcinomasn
Hanna Engqvist, Toshima Z Parris, Anikó Kovács, Szilard Nemes, Elisabeth Werner Rönnerman, Shahin De Lara, Jana Biermann, Karin Sundfeldt, Per Karlsson, Khalil Helou
BMC Cancer - 2019 -
Transcriptional effects of Lu-177-octreotate therapy using a priming treatment schedule on GOT1 tumor in nude
mice
Johan Spetz, Britta Langen, Nils Rudqvist, Toshima Z Parris, Emman Shubbar, Johanna Dalmo, Bo Wängberg, Ola Nilsson, Khalil Helou, Eva Forssell-Aronsson
Ejnmmi Research - 2019 -
The prognostic relevance of FOXA1 and Nestin expression in breast cancer metastases: a retrospective study of 164 cases during a 10-year period
(2004-2014)
Shahin De Lara, Jenny Nyqvist, Elisabeth Werner Rönnerman, Khalil Helou, E. K. Sarenmalm, Zakaria Einbeigi, Per Karlsson, Toshima Z Parris, Anikó Kovács
Bmc Cancer - 2019 -
Tumorigenic effects of TLX over-expression in HEK 293T
cells
Toshima Z Parris, Dzeneta Vizlin-Hodzic, Susanne Salmela, Keiko Funa
Cancer Reports - 2019 -
Tumour clonality in paired invasive breast
carcinomas
Jana Biermann, Toshima Z Parris, Szilard Nemes, Anna Danielsson, Hanna Engqvist, Elisabeth Werner Rönnerman, Eva Forssell-Aronsson, Anikó Kovács, Per Karlsson, Khalil Helou
Cancer Research - 2019 -
Radiation-induced genomic instability in breast carcinomas of the Swedish haemangioma
cohort.
Jana Biermann, Britta Langen, Szilard Nemes, Erik Holmberg, Toshima Z Parris, Elisabeth Werner Rönnerman, Hanna Engqvist, Anikó Kovács, Khalil Helou, Per Karlsson
Genes, chromosomes & cancer - 2019 -
Design and creation of a wearable circular ultrasonic device for a soft screening and diagnosis of breast
abnormalities
Amira Godih, Georges Nassar, Toshima Z Parris, Nadine Saad, Elie Helou, Per Karlsson, Khalil Helou
J Cancer Sci Clin Ther - 2019 -
Long-term effects in thyroid and plasma
after internal low dose exposure with 131I in
rat
Malin Larsson, Nils Rudqvist, Johan Spetz, Toshima Z Parris, Britta Langen, Khalil Helou, Eva Forssell-Aronsson
Gothenburg Cancer Meeting - 2019 -
Low-dose exposure of 131I in young rat thyroid tissue and
plasma
Malin Larsson, Nils Rudqvist, Johan Spetz, Toshima Z Parris, Britta Langen, Khalil Helou, Eva Forssell-Aronsson
European Radiation Protection Week - 2019 -
Transcriptomic and genomic profiling of early-stage ovarian carcinomas associated with histotype and overall
survival
Hanna Engqvist, Toshima Z Parris, Elisabeth Werner Rönnerman, Elin Söderberg, Jana Biermann, Constantina Mateoiu, Karin Sundfeldt, Anikó Kovács, Per Karlsson, Khalil Helou
Oncotarget - 2018 -
Genome-wide multi-omics profiling of the 8p11-p12 amplicon in breast
carcinoma.
Toshima Z Parris, Elisabeth Werner Rönnerman, Hanna Engqvist, Jana Biermann, Katarina Truvé, Szilard Nemes, Eva Forssell-Aronsson, Giovanni Solinas, Anikó Kovács, Per Karlsson, Khalil Helou
Oncotarget - 2018 -
GATA3 as a putative marker of breast cancer metastasis-A retrospective immunohistochemical
study.
Shahin De Lara, Toshima Z Parris, Elisabeth Werner Rönnerman, Khalil Helou, Anikó Kovács
The breast journal - 2018 -
Clonal relatedness in tumour pairs of breast cancer
patients.
Jana Biermann, Toshima Z Parris, Szilard Nemes, Anna Danielsson, Hanna Engqvist, Elisabeth Werner Rönnerman, Eva Forssell-Aronsson, Anikó Kovács, Per Karlsson, Khalil Helou
Breast cancer research : BCR - 2018 -
Time-dependent transcriptional response of GOT1 human small intestine neuroendocrine tumor after 177Lu-octreotate
therapy
Johan Spetz, Nils Rudqvist, Britta Langen, Toshima Z Parris, Johanna Dalmo, Emil Schüler, Bo Wängberg, Ola Nilsson, Khalil Helou, Eva Forssell-Aronsson
Nuclear Medicine and Biology - 2018 -
Mechanical ventilation promotes lung metastasis in experimental 4T1 breast cancer lung-metastasized
models
Ying-Lai Huang, L. Pan, Khalil Helou, Q. Xia, Toshima Z Parris, H. Li, B. Xu, H. Li
Cancer Management and Research - 2018 -
Transcriptional response to 131I exposure of rat thyroid
gland
Nils Rudqvist, Johan Spetz, Emil Schüler, Toshima Z Parris, Britta Langen, Khalil Helou, Eva Forssell-Aronsson
PLoS ONE - 2017 -
Early onset of inflammation during ontogeny of bipolar disorder: the NLRP2
inflammasome gene distinctly differentiates between patients and healthy
controls in the transition between iPS cell and neural stem cell
stages
Dzeneta Vizlin-Hodzic, Qiwei Zhai, Sebastian Illes, Kristoffer Södersten, Katarina Truvé, Toshima Z Parris, Praveen Sobhan, Susanne Salmela, Subazini Kosalai, Chandrasekhar Kanduri, Joakim Strandberg, Henrik Seth, Thomas Bontell, Eric Hanse, Hans Ågren, Keiko Funa
Translational Psychiatry - 2017 -
A novel 18-marker panel predicting clinical outcome in breast
cancer
Jana Biermann, Szilard Nemes, Toshima Z Parris, Hanna Engqvist, Elisabeth Werner Rönnerman, Eva Forssell-Aronsson, Gunnar Steineck, Per Karlsson, Khalil Helou
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 2017 -
Hedgehog inhibitor sonidegib potentiates 177Lu-octreotate therapy of GOT1 human small intestine neuroendocrine tumors in nude
mice
Johan Spetz, Britta Langen, Nils Rudqvist, Toshima Z Parris, Khalil Helou, Ola Nilsson, Eva Forssell-Aronsson
BMC Cancer - 2017 -
Priming increases the anti-tumor effect and therapeutic window of 177Lu-octreotate in nude mice bearing human small intestine neuroendocrine tumor
GOT1.
Johanna Dalmo, Johan Spetz, Mikael Montelius, Britta Langen, Yvonne Arvidsson, Henrik Johansson, Toshima Z Parris, Khalil Helou, Bo Wängberg, Ola Nilsson, Maria Ljungberg, Eva Forssell-Aronsson
EJNMMI Research - 2017 -
Spousal Cancer: A Systematic Review and Case Report of a Metachronous Presentation of Breast Cancer in a Genetically Unrelated
Couple
Anikó Kovács, Toshima Z Parris, Barbro Linderholm
Clinics in Oncology - 2017 -
Internal exposure of 131I – potential biomarkers and functional analysis for long-term effects in
thyroid
Malin Larsson, Nils Rudqvist, Johan Spetz, Toshima Z Parris, Britta Langen, Khalil Helou, Eva Forssell-Aronsson
European Journal of Nuclear Medicine and Molecular Imaging. 44 (Suppl. 2) - 2017 -
Metachronous and Synchronous Occurrence of 5 Primary Malignancies in a Female Patient between 1997 and 2013: A Case Report with Germline and Somatic Genetic
Analysis
Jenny Nyqvist, Fredrik Persson, Toshima Z Parris, Khalil Helou, Elisabeth Kenne Sarenmalm, Zakaria Einbeigi, Å. Borg, Per Karlsson, Anikó Kovács
Case Reports in Oncology - 2017 -
Age and sex: important variables in biomarker discovery for radiotherapy and risk
estimation.
Britta Langen, Johan Spetz, Toshima Z Parris, John Swanpalmer, Carina Sihlbom, Khalil Helou, Eva Forssell-Aronsson
Swedish Cancer Society planning group for oncological radionuclide therapy - 2017 -
Age and sex bias in biomarker discovery for radiotherapy and risk
estimation
Britta Langen, Johan Spetz, Toshima Z Parris, John Swanpalmer, Carina Sihlbom, Khalil Helou, Eva Forssell-Aronsson
63rd Annual Meeting of the Radiation Research Society, Cancun, Mexico - 2017 -
Transcriptome and proteome analysis for potential biomarker discovery of long-term effects in rat thyroid and blood tissue after I-131
exposure
Malin Larsson, Nils Rudqvist, Johan Spetz, Toshima Z Parris, Britta Langen, Khalil Helou, Eva Forssell-Aronsson
SweRays Workshop, Stockholm, Sweden, Aug 25-26 - 2016 -
Genome-wide multi-omics profiling reveals extensive genetic complexity in 8p11-p12 amplified breast
carcinomas
Toshima Z Parris, Hanna Engqvist, Katarina Truvé, Elisabeth Werner Rönnerman, Jana Biermann, Anikó Kovács, Per Karlsson, Khalil Helou
4th Swedish Cancer Research Meeting - 2016 -
Analysis of genetic abnormalities involved in the development of ovarian
tumors
Hanna Engqvist, Elisabeth Werner Rönnerman, Toshima Z Parris, Elin Söderberg, Jana Biermann, Karin Sundfeldt, Anikó Kovács, Per Karlsson, Khalil Helou
4th Swedish Cancer Research Meeting - 2016 -
Exposure of rats to 131I - potential biomarkers of long-term effects and cancer induction in the
thyroid
Malin Larsson, Nils Rudqvist, Johan Spetz, Toshima Z Parris, Britta Langen, Khalil Helou, Eva Forssell-Aronsson
Swedish Cancer Society autumn meeting, Uppsala, Sweden. - 2016 -
Exposure of rats to 131I - potential biomarkers of long-term effects and cancer induction in the
thyroid
Malin Larsson, Nils Rudqvist, Johan Spetz, Toshima Z Parris, Britta Langen, Khalil Helou, Eva Forssell-Aronsson
4th Swedish Cancer Research Meeting, 7-8 november 2016, Gothenburg, Sweden - 2016 -
Potential biomarkers for long-term effects in thyroid tissue after 131I exposure in
rats
Malin Larsson, Nils Rudqvist, Johan Spetz, Toshima Z Parris, Britta Langen, Khalil Helou, Eva Forssell-Aronsson
62nd Annual International Meeting Radiation Research Society, Waikoloa, HI, USA, October 16-19, 2016 - 2016 -
Importance of performing a histological reevaluation of ovarian carcinomas according to WHO
criteria
Elisabeth Werner Rönnerman, Hanna Engqvist, Jana Biermann, Pernilla Dahm-Kähler, Karin Sundfeldt, Toshima Z Parris, Per Karlsson, Shahin De Lara, Anikó Kovács, Khalil Helou
4 th Swedish Cancer Research Meeting Gothenburg 2016 - 2016 -
Genome-wide transcriptional response in normal tissues are influenced by time of day of i.v. injection of 131 in
mice
Eva Forssell-Aronsson, Britta Langen, Nils Rudqvist, Toshima Z Parris, Khalil Helou
The 14th Congress of the International Radiation Protection Association (IRPA), 9-13 May, 2016, Cape Town, South Africa - 2016 -
Circadian rhythm influences genome-wide transcriptional responses to I-131 in a tissue-specific manner in
mice
Britta Langen, Nils Rudqvist, Toshima Z Parris, Khalil Helou, Eva Forssell-Aronsson
EJNMMI Research - 2015 -
Transcriptional response in normal mouse tissues after i.v. 211At administration - response related to absorbed dose, dose rate, and
time
Britta Langen, Nils Rudqvist, Toshima Z Parris, Emil Schüler, Johan Spetz, Khalil Helou, Eva Forssell-Aronsson
EJNMMI Research - 2015 -
Biomarker gene discovery for radionuclide exposure and the impact of circadian variation and data
convolution
Britta Langen, Nils Rudqvist, Toshima Z Parris, Johan Spetz, Khalil Helou, Eva Forssell-Aronsson
Cancerfondens planeringsgrupp för onkologisk radionuklidterapi, Höstmöte, Linköping, Sweden, November 25-27, 2015 - 2015 -
Transcriptional effects of 177Lu-octreotate therapy on GOT1 tumor in nude mice using conventional and priming treatment
schedules
Johan Spetz, Johanna Dalmo, Nils Rudqvist, Britta Langen, Toshima Z Parris, Bo Wängberg, Ola Nilsson, Khalil Helou, Eva Forssell-Aronsson
15th International Congress of Radiation Research, Kyoto, Japan, May 25-29 - 2015 -
Gene expression signature in mouse thyroid tissue after 131I and 211At
exposure
Eva Forssell-Aronsson, Nils Rudqvist, Johan Spetz, Emil Schüler, Britta Langen, Toshima Z Parris, Khalil Helou
Cancerfondens riksplaneringsgrupp för onkologisk radionuklidterapi, Höstmöte, Linköping, Sweden, November 25-27, 2015 (invited) - 2015 -
Gene expression signature in mouse thyroid tissue after 131I and 211At
exposure
Nils Rudqvist, Johan Spetz, Emil Schüler, Britta Langen, Toshima Z Parris, Khalil Helou, Eva Forssell-Aronsson
EJNMMI Research - 2015 -
Transcriptomic effects on GOT2 tumor in nude mice ̶ comparison between 177Lu-octreotate and external beam
treatments
Johan Spetz, Britta Langen, Toshima Z Parris, Emil Schüler, John Swanpalmer, Bo Wängberg, Ola Nilsson, Khalil Helou, Eva Forssell-Aronsson
Cancerfondens riksplaneringsgrupp för onkologisk radionuklidterapi. Vintermöte, Umeå, Sverige, Jan 22-23 - 2015 -
Hedgehog inhibitor Sonidegib potentiates 177Lu-octreotate therapy of GOT1 human small intestine neuroendocrine tumors in nude
mice
Johan Spetz, Nils Rudqvist, Britta Langen, Toshima Z Parris, Bo Wängberg, Ola Nilsson, Khalil Helou, Eva Forssell-Aronsson
Cancerfondens riksplaneringsgrupp för onkologisk radionuklidterapi, Höstmöte, Linköping, Sweden, November 25-27, 2015 - 2015 -
Potential Biomarkers for Radiation-Induced Renal Toxicity following 177Lu-Octreotate Administration in
Mice.
Emil Schüler, Maria Larsson, Toshima Z Parris, Martin E Johansson, Khalil Helou, Eva Forssell-Aronsson
PloS one - 2015 -
Transcriptional Response in Mouse Thyroid Tissue after 211At Administration: Effects of Absorbed Dose, Initial Dose-Rate and Time after
Administration
Nils Rudqvist, Johan Spetz, Emil Schüler, Toshima Z Parris, Britta Langen, Khalil Helou, Eva Forssell-Aronsson
PLoS ONE - 2015 -
Proteomic analysis of normal mouse thyroids after 131I
administration
Toshima Z Parris, Nils Rudqvist, Britta Langen, Johan Spetz, Emil Schüler, Khalil Helou, Eva Forssell-Aronsson
15th International Congress of Radiation Research, Kyoto, Japan, May 25-29 - 2015 -
Dose-specific transcriptional responses in thyroid tissue in mice after (131)I
administration.
Nils Rudqvist, Emil Schüler, Toshima Z Parris, Britta Langen, Khalil Helou, Eva Forssell-Aronsson
Nuclear medicine and biology - 2015 -
Identification of Dbp as a candidate biomarker gene of low-level 131I exposure that affects thyroid
function
Nils Rudqvist, Johan Spetz, Emil Schüler, Toshima Z Parris, Britta Langen, Khalil Helou, Eva Forssell-Aronsson
15th International Congress of Radiation Research, Kyoto, Japan, May 25-29 - 2015 -
Data convolution and circadian rhythm impact identification of biomarker genes for ionizing radiation exposure in vivo: concept study on 131I exposure in mouse
thyroid
Britta Langen, Nils Rudqvist, Toshima Z Parris, Johan Spetz, Khalil Helou, Eva Forssell-Aronsson
15th International Congress of Radiation Research, Kyoto, Japan, May 25-29 - 2015 -
Circadian rhythm affects transcriptome responses in mouse normal tissues to i.v. administered
I-131.
Britta Langen, Nils Rudqvist, Toshima Z Parris, Khalil Helou, Eva Forssell-Aronsson
6th International MELODI Workshop, Barcelona, Spain, Oct 7-9, 2014. - 2014 -
Relationships between transcriptional regulation profiles of 27 genes commonly regulated in mice after 131I and 211At
exposure
Nils Rudqvist, Johan Spetz, Toshima Z Parris, Emil Schüler, Britta Langen, Khalil Helou, Eva Forssell-Aronsson
Swedish Radiation Research Association for Young Scientists (Swe-Rays) workshop, Malmoe, Sweden, August 20-22, 2014 - 2014 -
Genetic signatures detected in thyroid tissue in mice after 131I and 211At
exposure
Nils Rudqvist, Toshima Z Parris, Britta Langen, Emil Schüler, Johan Spetz, Khalil Helou, Eva Forssell-Aronsson
60th Annual Meeting of the Radiation Research Society, Las Vegas, NV, USA, September 20-24, 2014 - 2014 -
Transcriptional Relationships and Biological Functions of 27 Genes Commonly Regulated in Thyroid Tissue in Mice after 131I and 211At
Exposure
Nils Rudqvist, Johan Spetz, Toshima Z Parris, Emil Schüler, Britta Langen, Khalil Helou, Eva Forssell-Aronsson
27th Annual Congress on European Association of Nuclear Medicine, Gothenburg, Sweden, October 18-22, 2014 - 2014 -
Transcriptional response of kidney tissue after (177)Lu-octreotate administration in
mice.
Emil Schüler, Nils Rudqvist, Toshima Z Parris, Britta Langen, Khalil Helou, Eva Forssell-Aronsson
Nuclear medicine and biology - 2014 -
Optimization of 177Lu-octreotate treatment of neuroendocrine
tumours
Eva Forssell-Aronsson, Johan Spetz, Britta Langen, Johanna Dalmo, Maria Larsson, Mikael Montelius, Nils Rudqvist, Toshima Z Parris, Yvonne Arvidsson, Maria Ljungberg, Khalil Helou, Ola Nilsson, Bo Wängberg
3rd Swedish Cancer Research Meeting, Stockholm, Sweden, September 2-3, 2014 - 2014 -
Distinct microRNA Expression Profiles in Mouse Renal Cortical Tissue after 177Lu-octreotate
Administration.
Emil Schüler, Toshima Z Parris, Khalil Helou, Eva Forssell-Aronsson
PloS one - 2014 -
Time- and dose rate-related effects of internal (177)Lu exposure on gene expression in mouse kidney
tissue.
Emil Schüler, Nils Rudqvist, Toshima Z Parris, Britta Langen, Johan Spetz, Khalil Helou, Eva Forssell-Aronsson
Nuclear medicine and biology - 2014 -
Transcriptional response of GOT1 midgut carcinoid in nude mice following 177Lu-octreotate
treatment
Johan Spetz, Johanna Dalmo, Nils Rudqvist, Britta Langen, Toshima Z Parris, Bo Wängberg, Ola Nilsson, Khalil Helou, Eva Forssell-Aronsson
27th Annual Congress on European Association of Nuclear Medicine, Gothenburg, Sweden, October 18-22, 2014 - 2014 -
Transcriptional response in mouse to i.v. administered 131I is affected by time of day in a tissue-specific
manner.
Britta Langen, Nils Rudqvist, Toshima Z Parris, Khalil Helou, Eva Forssell-Aronsson
60th Annual Meeting of the Radiation Research Society (RRS), Las Vegas, USA, Sep 21-24, 2014. - 2014 -
Regulation of the viability of Nf1 deficient cells by PKC
isoforms.
Xiaodong Zhou, Ling Shen, Toshima Z Parris, Junchi Huang, Bo Yi, Khalil Helou, Changyan Chen
Oncotarget - 2014 -
Frequent MYC coamplification and DNA hypomethylation of multiple genes on 8q in 8p11-p12-amplified breast
carcinomas
Toshima Z Parris, Anikó Kovács, Shahin Hajizadeh, Szilard Nemes, May Semaan, Max Levin, Per Karlsson, Khalil Helou
Oncogenesis - 2014 -
Combination therapy with hedgehog inhibitor LDE225 increases efficacy of 177Lu-octreotate therapy on GOT1 tumors in nude
mice
Johan Spetz, Britta Langen, Nils Rudqvist, Toshima Z Parris, Bo Wängberg, Ola Nilsson, Khalil Helou, Eva Forssell-Aronsson
27th Annual Congress on European Association of Nuclear Medicine, Gothenburg, Sweden, October 18-22, 2014 - 2014 -
Transcriptional responses to i.v. administered I-131 underlie diurnal variation in normal mouse tissues - implications for biomarker
discovery
Britta Langen, Nils Rudqvist, Toshima Z Parris, Khalil Helou, Eva Forssell-Aronsson
Swedish Radiation Research Association for Young Scientists (Swe-Rays) workshop, Malmoe, Sweden, August 20-22, 2014 - 2014 -
Effects of internal irradiation from 177Lu-octreotate on transcriptional expression in GOT1 midgut carcinoid in nude
mice
Johan Spetz, Johanna Dalmo, Britta Langen, Toshima Z Parris, Bo Wängberg, Ola Nilsson, Khalil Helou, Eva Forssell-Aronsson
SweRays Workshop, Malmö, Sweden, Aug 20-22 - 2014 -
Hedgehog inhibitor LDE225 increases efficacy of 177Lu-octreotate therapy on GOT1 tumors in nude
mice
Johan Spetz, Britta Langen, Toshima Z Parris, Bo Wängberg, Ola Nilsson, Khalil Helou, Eva Forssell-Aronsson
60th Annual Meeting of the Radiation Research Society, Las Vegas, USA, September 20-24, 2014 - 2014 -
Fractionated 177Lu-octreotate therapy of human GOT1 tumors in nude mice increases treatment efficacy, possibly via SSTR
up-regulation
Johan Spetz, Britta Langen, Johanna Dalmo, Nils Rudqvist, Toshima Z Parris, Bo Wängberg, Ola Nilsson, Khalil Helou, Eva Forssell-Aronsson
3rd Swedish Cancer Research Meeting, Stockholm, Sweden, September 2-3, 2014 - 2014 -
Priming administration before the main administration of 177Lu-octreotate increases the therapeutic effect in nude mice bearing human carcinoid tumor
GOT1
Johanna Dalmo, Johan Spetz, Mikael Montelius, Britta Langen, Yvonne Arvidsson, Henrik Johansson, Toshima Z Parris, Khalil Helou, Bo Wängberg, Ola Nilsson, Maria Ljungberg, Eva Forssell-Aronsson
27th Annual Congress on European Association of Nuclear Medicine, Gothenburg, Sweden, October 18-22, 2014 - 2014 -
Clinical relevance of breast cancer-related genes as potential biomarkers for oral squamous cell
carcinoma
Toshima Z Parris, Luaay Aziz, Anikó Kovács, Shahin Hajizadeh, Szilard Nemes, May Semaan, Chang Yan Chen, Per Karlsson, Khalil Helou
BMC Cancer - 2014 -
Time of day affects transcriptional response to i.v. administered I-131 in mouse normal tissues – implications for biomarker
discovery.
Britta Langen, Nils Rudqvist, Toshima Z Parris, Khalil Helou, Eva Forssell-Aronsson
27th Annual Congress of the European Association of Nuclear Medicine (EANM), Gothenburg, Sweden, Oct 18-22, 2014. - 2014 -
Additive effect of the AZGP1, PIP, S100A8, and UBE2C molecular biomarkers improves outcome prediction in breast
carcinoma
Toshima Z Parris, Anikó Kovács, Luaay Aziz, Shahin Hajizadeh, Szilard Nemes, May Semaan, Eva Forssell-Aronsson, Per Karlsson, Khalil Helou
International Journal of Cancer - 2014 -
Radiobiological effects on gene expression levels in mouse thyroid after irradiation with
astatine-211
Nils Rudqvist, Toshima Z Parris, Szilard Nemes, Khalil Helou, Eva Forssell-Aronsson
Targeting Alpha-Particle Emitting Radionuclides to Combat Cancer (TARCC) congress: Advances in targeted radionuclide therapy, Ljubljana, Slovenia, December 1-2, 2010 - 2013 -
Differential gene expression in human fibroblasts after alpha-particle emitter (211)At compared with (60)Co
irradiation.
Anna Danielsson, Kristina Claesson, Toshima Z Parris, Khalil Helou, Szilard Nemes, Kerstin Elmroth, Jörgen Elgqvist, Holger Jensen, Ragnar Hultborn
International journal of radiation biology - 2013 -
Comparative Analysis of Transcriptional Gene Regulation Indicates Similar Physiologic Response in Mouse Tissues at Low Absorbed Doses from Intravenously Administered
At-211
Britta Langen, Nils Rudqvist, Toshima Z Parris, Emil Schüler, Khalil Helou, Eva Forssell-Aronsson
Journal of Nuclear Medicine - 2013 -
Radiation-induced transcriptional response in mouse thyroid and systemic effects on liver, lungs, kidney and
spleen.
Nils Rudqvist, Britta Langen, Emil Schüler, Toshima Z Parris, Khalil Helou, Eva Forssell-Aronsson
SweRays Workshop, Uppsala, Aug 21-23. - 2013 -
Elevated cyclin B2 expression in invasive breast carcinoma is associated with unfavorable clinical
outcome.
Emman Shubbar, Anikó Kovács, Shahin Hajizadeh, Toshima Z Parris, Szilard Nemes, Katrin Gunnarsdóttir, Zakaria Einbeigi, Per Karlsson, Khalil Helou
BMC cancer - 2013 -
Increased therapeutic response from fractionated 177 Lu-octreotate therapy of GOT1 tumors in nude
mice.
Johan Spetz, Johanna Dalmo, Britta Langen, Toshima Z Parris, Bo Wängberg, Ola Nilsson, Khalil Helou, Eva Forssell-Aronsson
Cancerfondens planeringsgrupp för onkologisk radionuklidterapi. Höstmöte, Göteborg, Sverige, Nov 13-15. - 2013 -
Combination therapy of GOT 1 tumours in nude mice using 177 Lu-octreotate and the hedgehog inhibitor
LDE225.
Johan Spetz, Johanna Dalmo, Britta Langen, Toshima Z Parris, Bo Wängberg, Ola Nilsson, Khalil Helou, Eva Forssell-Aronsson
SweRays Workshop, Uppsala, Sweden, Aug 21-25, 2013. - 2013 -
Fractionated 177Lu-octreotate therapy of GOT1 tumors in nude mice increases treatment efficacy, possibly via SSTR
up-regulation
Johan Spetz, Johanna Dalmo, Britta Langen, Toshima Z Parris, Bo Wängberg, Ola Nilsson, Khalil Helou, Eva Forssell-Aronsson
59th Annual Meeting of the Radiation Research Society, New Orleans, USA, September 15-19, 2013 - 2013 -
Transcriptional effects on normal tissues after administration of 211At in
mice.
Eva Forssell-Aronsson, Nils Rudqvist, Britta Langen, Toshima Z Parris, Emil Schüler, Khalil Helou
8th International Symposium on Target Alpha Therapy. Oak Ridge, USA. - 2013 -
Early transcriptional regulation following low-activity 211 At exposure in mouse and related systemic physiological
aspects.
Britta Langen, Nils Rudqvist, Toshima Z Parris, Emil Schüler, Johan Spetz, Khalil Helou, Eva Forssell-Aronsson
SWERays Workshop, Uppsala, Sweden, Aug 21-23. - 2013 -
Short-term study of transcriptional regulation following low-dose astatine -211 exposure in
mouse.
Britta Langen, Nils Rudqvist, Toshima Z Parris, Emil Schüler, Johan Spetz, Khalil Helou, Eva Forssell-Aronsson
SNMMI , Vancouver , Canada. - 2013 -
Micro-RNA signature of 177Lu-octreotate treatment effects in renal cortical
tissue.
Emil Schüler, Toshima Z Parris, Khalil Helou, Eva Forssell-Aronsson
Cancerfondens planeringsgrupp för onkologisk radionuklidterapi, Göteborg, Sverige, Nov 13-15. - 2013 -
Relevance of systemic physiological aspects in radionuclide therapy. System Biology
Meeting.
Britta Langen, Nils Rudqvist, Toshima Z Parris, Emil Schüler, Khalil Helou, Eva Forssell-Aronsson
2013 CSHL Meeting on Systems Biology: Networks. Cold Spring Harbor, New York, USA - 2013 -
Dose-rate effects in radionuclide therapy: global transcriptional regulation in kidney tissue in vivo after 177LuCl3
administration.
Emil Schüler, Nils Rudqvist, Toshima Z Parris, Britta Langen, Khalil Helou, Eva Forssell-Aronsson
SweRays Workshop, Uppsala, Aug 21-23. - 2013 -
Radiation-induced transcriptional response in thyroid change with time in mice exposed to 211
At.
Nils Rudqvist, Britta Langen, Emil Schüler, Toshima Z Parris, Khalil Helou, Eva Forssell-Aronsson
Cancerfondens planeringsgrupp för onkologisk radionuklidterapi, Göteborg, Sverige, Nov 13-15. - 2013 -
Radiation-induced transcriptional response in kidneys, liver, spleen, and thyroid in mice exposed to 211
At.
Nils Rudqvist, Britta Langen, Emil Schüler, Toshima Z Parris, Khalil Helou, Eva Forssell-Aronsson
59th Annual Meeting of the Radiation Research Society, New Orleans, USA, September, 15-19. - 2013 -
Radiation-induced transcriptional response in kidneys, liver, lungs, spleen and thyroid in mice exposed to 211
At.
Nils Rudqvist, Britta Langen, Emil Schüler, Toshima Z Parris, Khalil Helou, Eva Forssell-Aronsson
Workshop: Radiobiology Applied to oncology, Lesponne, France - 2013 -
Relevance of systemic physiological aspects in radionuclide
therapy.
Britta Langen, Nils Rudqvist, Toshima Z Parris, Emil Schüler, Khalil Helou, Eva Forssell-Aronsson
Meeting with VR planning group on NE tumors, Göteborg, Sweden - 2013 -
Transcriptional effects on normal tissues after administration of 211At in
mice.
Eva Forssell-Aronsson, Nils Rudqvist, Britta Langen, Toshima Z Parris, Emil Schüler, Khalil Helou
Fifth International MELODI (Multidisciplinary European Low Dose Initiative) Workshop, Brussels, Oct 7-10, 2013 - 2013 -
Dose-rate effects in radionuclide therapy:global transcriptional regulation in kidney tissue in vivo after 177LuCl3
administration.
Emil Schüler, Nils Rudqvist, Toshima Z Parris, Britta Langen, Khalil Helou, Eva Forssell-Aronsson
59th Annual Meeting of the Radiation Research Society, New Orleans, USA, September, 15-19. - 2013 -
Prognostic value of a four marker panel associated with breast cancer-specific
survival.
Toshima Z Parris, A Kovacs, Shahin Hajizadeh, Szilard Nemes, M Semann, Eva Forssell-Aronsson, P Karlsson, Khalil Helou
The 5th IMPAKT Breast Cancer Conference, Brussels, Belgium - 2013 -
Integrative genomics with mediation analysis in a survival
context.
Szilard Nemes, Toshima Z Parris, Anna Danielsson, Zakaria Einbeigi, Gunnar Steineck, Junmei Miao Jonasson, Khalil Helou
Computational and mathematical methods in medicine - 2013 -
Radiobiologiska effekter på thyroidea efter exponering för 211At och
131I
Eva Forssell-Aronsson, Nils Rudqvist, Britta Langen, Toshima Z Parris, Emil Schüler, Khalil Helou
Strålsäkerhetsmyndighetens forskningsdagar, Oct 24-25, 2013, Stockholm - 2013 -
A diagnostic algorithm to identify paired tumors with clonal
origin.
Szilard Nemes, Anna Danielsson, Toshima Z Parris, Junmei Miao Jonasson, Erik Bülow, Per Karlsson, Gunnar Steineck, Khalil Helou
Genes, chromosomes & cancer - 2013 -
High-risk breast cancer: From biology to personalized therapeutic
strategies
Toshima Z Parris
2013 -
Inversion upstream of FOXF1 in a case of lethal alveolar capillary dysplasia with misalignment of pulmonary
veins.
Toshima Z Parris, Ali Moussavi Nik, Sailesh Kotecha, Claire Langston, Khalil Helou, Craig Platt, Peter Carlsson
American journal of medical genetics. Part A - 2013 -
Segmented regression, a versatile tool to analyze mRNA levels in relation to DNA copy number
aberrations.
Szilard Nemes, Toshima Z Parris, Anna Danielsson, Marie Kannius-Janson, Junmei Miao Jonasson, Gunnar Steineck, Khalil Helou
Genes, chromosomes & cancer - 2012 -
Distinct gene expression response in kidney tissue after injection with
177Lu-octreotate
Emil Schüler, Toshima Z Parris, Nils Rudqvist, Khalil Helou, Eva Forssell-Aronsson
Society of Nuclear Medicine (SNM) Congress, Miami June 9-13, 2012 - 2012 -
Kidney toxicity in mice treated with
177Lu-octreotate
Maria Larsson, Emil Schüler, Toshima Z Parris, Nils Rudqvist, Khalil Helou, Håkan Ahlman, Eva Forssell-Aronsson
25th Annual Congress on European Association of Nuclear Medicine, Milano, Italy, October 27-31, 2012 . (European Journal of Nuclear Medicine and Molecular Imaging) - 2012 -
Dose-rate related effects on gene expression in kidney tissue after intravenous injection of 177LuCl3 in
mouse
Emil Schüler, Nils Rudqvist, Toshima Z Parris, Britta Langen, Khalil Helou, Eva Forssell-Aronsson
EANM'12 Annual Congress of the European association of nuclear medicine. Milan, Italy, October 27 - 31, 2012 - 2012 -
Common threshold response of transcriptional gene regulation after i.v. 211At exposure in abdominal organs and the
lung
Britta Langen, Nils Rudqvist, Emil Schüler, Toshima Z Parris, Khalil Helou, Eva Forssell-Aronsson
25th Annual Congress on European Association of Nuclear Medicine, Milano, Italy, October 27-31, 2012 - 2012 -
Regulation of gene expression in GOT1 midgut carcinoid in nude mice following injection with
177Lu-octreotate
Johan Spetz, Britta Langen, Toshima Z Parris, Nils Rudqvist, Khalil Helou, Ola Nilsson, Håkan Ahlman, Eva Forssell-Aronsson
25th Annual Congress on European Association of Nuclear Medicine, Milano, Italy, October 27-31, 2012 - 2012 -
Effects of internal irradiation from 177Lu-octreotate on gene expression in GOT1 midgut carcinoid in nude
mice
Johan Spetz, Britta Langen, Toshima Z Parris, Nils Rudqvist, Khalil Helou, Ola Nilsson, Håkan Ahlman, Eva Forssell-Aronsson
58th Annual Meeting of the Radiation Research Society, San Juan, Puerto Rico, September 30 - October 3, 2012 - 2012 -
Transcriptional gene regulation in abdominal organs and the lung after i.v. injection of 211At in
mouse
Britta Langen, Nils Rudqvist, Toshima Z Parris, Emil Schüler, Khalil Helou, Eva Forssell-Aronsson
Radiation research society. San Juan, Puerto Rico. 2012 - 2012 -
Astatine-211 exposure of Balb/c mice in vivo resulted in distinct effets on thyroid at 1, 6 hours and 7 days after
injection
Nils Rudqvist, Toshima Z Parris, Emil Schüler, Britta Langen, Khalil Helou, Eva Forssell-Aronsson
58th Annual Meeting of the Radiation Research Society, San Juan, Puerto Rico, September 30 - October 3, 2012 - 2012 -
Biological effects of 177Lu-octreotate therapy in mouse: in vivo normal kidney tissue response evaluated with gene expression
microarray
Emil Schüler, Nils Rudqvist, Toshima Z Parris, Britta Langen, Khalil Helou, Eva Forssell-Aronsson
58th Annual Meeting of the Radiation Research Society. San Juan, Puerto Rico. 2012 - 2012 -
Balb/c mice thyroids revealed distinct effects on gene expression at 1, 6 hours and 7 days after injection of exposure to
astatine-211
Nils Rudqvist, Toshima Z Parris, Emil Schüler, Britta Langen, Khalil Helou, Eva Forssell-Aronsson
25th Annual Congress on European Association of Nuclear Medicine, Milano, Italy, October 27-31, 2012 - 2012 -
Transcriptional response of BALB/c mouse thyroids following in vivo astatine-211 exposure reveals distinct gene expression
profiles.
Nils Rudqvist, Toshima Z Parris, Emil Schüler, Khalil Helou, Eva Forssell-Aronsson
EJNMMI research - 2012 -
Effects of internal low-dose irradiation from 131I on gene expression in normal tissues in Balb/c
mice.
Emil Schüler, Toshima Z Parris, Nils Rudqvist, Khalil Helou, Eva Forssell-Aronsson
EJNMMI research - 2011 -
In vivo iodine-131 exposure reveals distinct absorbed dose-dependent gene expression profiles in mouse thyroid
tissue
Nils Rudqvist, Toshima Z Parris, Emil Schüler, Khalil Helou, Eva Forssell-Aronsson
Conference: From dosimetry to biological effect: radiobiology as guide to clinical practice in nuclear medicine. Sorrento - 2011 -
Effects on gene expression in normal mouse tissues following low dose 131I
irradiation
Emil Schüler, Toshima Z Parris, Nils Rudqvist, Khalil Helou, Eva Forssell-Aronsson
European Association of Nuclear Medicine Congress. Birmingham - 2011 -
Biological effects on normal tissues following low dose 131I irradiation; microarray and gene expression
analyses
Emil Schüler, Toshima Z Parris, Nils Rudqvist, Khalil Helou, Eva Forssell-Aronsson
Conference: From dosimetry to biological effect: radiobiology as guide to clinical practice in nuclear medicine. Sorrento - 2011 -
Effects of low dose 131I irradiation on gene expression in normal mouse
tissues
Emil Schüler, Toshima Z Parris, Nils Rudqvist, Khalil Helou, Eva Forssell-Aronsson
European association of nuclear medicine, Birmingham 2011 - 2011 -
The transcriptional response to in vivo astatine-211 exposure of mouse thyroids reveals distinct absorbed dose-dependent
profiles
Nils Rudqvist, Toshima Z Parris, Emil Schüler, Khalil Helou, Eva Forssell-Aronsson
Conference: From dosimetry to biological effect: radiobiology as guide to clinical practice in nuclear medicine. Sorrento - 2011 -
Transcriptional response of mouse thyroids following in vivo astatine-211 exposure reveals distinct gene expression
profiles
Nils Rudqvist, Toshima Z Parris, Szilard Nemes, Khalil Helou, Eva Forssell-Aronsson
European Association of Nuclear Medicine Congress. Birmingham - 2011 -
Effects on gene expression in normal mouse tissues following low dose 131I
irradiation
Emil Schüler, Toshima Z Parris, Nils Rudqvist, Khalil Helou, Eva Forssell-Aronsson
14th International Congress of Radiation Research. Warsaw, Poland - 2011 -
In vivo astatine-211 exposure reveals distinct dose dependent gene expression profiles in mouse thyroid
tissue
Nils Rudqvist, Toshima Z Parris, Emil Schüler, Khalil Helou, Eva Forssell-Aronsson
14th International Congress of Radiation Research. Warsaw, Poland - 2011 -
Radiobiological effects (changes in gene expression) on mouse thyroid after irradiation with 211At or
131I
Nils Rudqvist, Toshima Z Parris, Szilard Nemes, Khalil Helou, Eva Forssell-Aronsson
10th Congress of the World Federation of Nuclear Medicine and Biology, Cape Town, South Africa, September 18-23, 2010 - 2010 -
Radiobiological effects on transcriptome in mouse thyroid after irradiation with
At-211
Nils Rudqvist, Toshima Z Parris, Szilard Nemes, Khalil Helou, Eva Forssell-Aronsson
Workshop on biology of ionizing radiation, Berder Island, France, September 22-25, 2010 - 2010 -
Radiobiological effects on gene expression levels in mouse thyroids after irradiation with
At-211
Nils Rudqvist, Toshima Z Parris, Szilard Nemes, Khalil Helou, Eva Forssell-Aronsson
38th Annual Meeting of the European Radiation Research Society, Stockholm, Sweden, September 5-9, 2010 - 2010 -
Radiobiological effects on gene expression levels in normal mouse thyroid after I-131
irradiation
Nils Rudqvist, Toshima Z Parris, Szilard Nemes, Khalil Helou, Eva Forssell-Aronsson
38th Annual Meeting of the European Radiation Research Society, Stockholm, Sweden, September 5-9, 2010 - 2010 -
High-resolution genomic profiling to predict 10-year overall survival in node-negative breast
cancer.
Elin Möllerström, Ulla Delle, Anna Danielsson, Toshima Z Parris, Björn Olsson, Per Karlsson, Khalil Helou
Cancer genetics and cytogenetics - 2010 -
Up-regulation of cell cycle arrest protein BTG2 correlates with increased overall survival in breast cancer, as detected by immunohistochemistry using tissue
microarray.
Elin Möllerström, Anikó Kovács, Kristina Lövgren, Szilard Nemes, Ulla Delle, Anna Danielsson, Toshima Z Parris, Donal J Brennan, Karin Jirstrom, Per Karlsson, Khalil Helou
BMC cancer - 2010 -
Clinical implications of gene dosage and gene expression patterns in diploid breast
carcinoma.
Toshima Z Parris, Anna Danielsson, Szilard Nemes, Anikó Kovács, Ulla Delle, Ghita Fallenius, Elin Möllerström, Per Karlsson, Khalil Helou
Clinical cancer research : an official journal of the American Association for Cancer Research - 2010