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Toshima Parris
Researcher
Department of OncologyAbout Toshima Parris
Research area: Translational research on the development of novel treatment options for breast- and ovarian cancer.
Research environment Toshima Parris works in a multidisciplinary research group comprised of several biologists (molecular biologist/geneticist), specialists in oncology, pathology, surgery, and radiation physics, as well as, one PhD student and a Masters student. Her research is conducted at the Department of Oncology and Sahlgrenska Center for Cancer Research.
Background The main objective of this proposal is to discover new treatment options for triple-negative breast cancer (TNBC) that prevent recurrence and metastasis. In 2018, approximately 2.1 million new breast cancer cases were reported worldwide. TNBC accounts for about 15-20% of these cases and is an aggressive form of breast cancer (grows rapidly and tends to metastasize) frequently found in women under the age of 50. Due to resistance to most common breast cancer treatments, battling TNBC has proven difficult. About 30% of TNBCs will recur within the first three years after initial diagnosis and 5-year survival rates are drastically lower (77%) than other types of breast cancer (93%). We propose a strategy to test combination therapies on TNBCs in vitro and in vivo. If successful, my work may not only pinpoint promising treatment strategies that can be used for future testing in clinical trials, but also identify genes that play a pivotal role in response/resistance to certain treatment options. These genes, in turn, may be used as diagnostic tools to identify patients that would most benefit from a specific type of treatment.
Research tools and resources
- In vitro studies: Cell lines, spheroids, patient-derived organoids, drug screening
- Biobanking of patient samples
- Flow cytometry, immunohistochemistry, tissue microarrays (TMA), RNA-seq, DNA methylation profiling, Immunoblot, quantitative real-time PCR (qPCR), and fluorescence in situ hybridization (FISH)
- Bioinformatics analyses of pan-cancer data: RNA-seq, mutation signatures, DNA copy number profiling, drug sensitivity data
- Drug repurposing: Transcriptomics- and structure-based virtual screening
- Epidemiologic studies using national registers: Swedish National Register for Breast Cancer (NBCR), National Patient Register, and Swedish Cause of Death Register
Current group members
- Maxim Olsson, PhD student
- Slavica Janeva, Postdoc
- Jenny Nyqvist-Streng, Postdoc
- Sithumini Sarathchandra, Master's student
Financial support
- King Gustav V Jubilee Clinic Research Foundation
- Familjen Knut och Ragnvi Jacobsson
- Assar Gabrielsson Research Foundation for Clinical Cancer Research
- Sahlgrenska University Hospital Research Foundation
- Magnus Bergvall Research Foundation
- Wilhelm och Martina Lundgren Research Foundation
- Åke Wiberg Research Foundation
- The Swedish Society of Medicine
- Anna-Lisa och Bror Björnsson Research Foundation
- Cancer and Allergy Research Foundation
Awards
- Top 100 cancer (#4) Scientific Reports papers in 2020, https://doi.org/10.1038/s41598-020-62848-5.
Professional organizations
- The European Association for Cancer Research (EACR)
- Swedish Association of Scientists (Naturvetarna)
- Swedish Association of Scientists at the University of Gothenburg (Naturvetarna vid GU)
- Swedish Society of Medicine (Svenska Läkaresällskapet)
- Radiation Research Society (RADRES)
- American Association of Cancer Research (AACR)
Associate Editor
- BMC Cancer, Journal of Ovarian Research, Frontiers in Medicine, Frontiers in Genetics (Cancer Genetics and Oncogenomics), Frontiers in Oncology (Breast Cancer)
Popular science articles
- Parris TZ. Bröstcancerpatientens tumör innehåller prognostisk information. Onkologi i Sverige 02-2014, 72-78.
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Age and comorbidity in relation to treatment and survival outcomes in triple-negative breast cancer: A Swedish nationwide registry-based
study.
Jenny Nyqvist-Streng, Josef Somi, Jari Martikainen, Maxim Olsson, Khalil Helou, Chaido Chamalidou, Anikó Kovács, Toshima Z Parris
Journal of geriatric oncology - 2025 -
The prognostic value of changes in Ki67 following neoadjuvant chemotherapy in residual triple-negative breast cancer: a Swedish nationwide registry-based
study
Jenny Nyqvist-Streng, Mikael Helou, Khalil Helou, Chaido Chamalidou, Anikó Kovács, Toshima Z Parris
Breast Cancer Research and Treatment - 2025 -
Attenuated titin protein expression is associated with advanced stages of ovarian
cancer
Harvey Sharma, Jaskaran Aujla, Asad Nawaz, Thabet Khasawneh, Ayesha Alvero, Robert T. Morris, Asma Basha, Laila Tutunji, Toshima Z Parris, Khalil Helou, Ghassan M. Saed
Molecular Therapy Oncology - 2025 -
Survival outcomes in hormone receptor-negative breast cancer among BRCA carriers versus noncarriers in western
Sweden.
Anna-Karin Tzikas, Erik Holmberg, Toshima Z Parris, Anikó Kovács, Lovisa Lovmar, Per Karlsson
Acta Oncologica - 2025 -
Integrative analysis of epigenetic and transcriptional interrelations identifies histotype-specific biomarkers in early-stage ovarian
carcinoma
Hugo Swenson, Ella Ittner, Lucas Werner, Elisabeth Werner Ronnerman, Claudia Mateoiu, Aniko Kovacs, Pernilla Dahm-Kähler, Ghassan M. Saed, Szilard Nemes, Per Karlsson, Toshima Z Parris, Khalil Helou
JOURNAL OF OVARIAN RESEARCH - 2025 -
Genetic, clinical, lifestyle and sociodemographic risk factors for head and neck cancer: A UK Biobank
study.
Lisa Tuomi, Toshima Z Parris, Araz Rawshani, Erik Andersson, Alina Orozco, Caterina Finizia
PLOS ONE - 2025 -
Effects of recombinant α1-microglobulin on early proteomic response in risk organs after exposure to
177Lu-octreotate
Charlotte Ytterbrink, Emman Shubbar, Toshima Z Parris, Britta Langen, Malin Druid, Emil Schüler, Sven Erik Strand, Bo Åkerström, Magnus Gram, Khalil Helou, Eva Forssell-Aronsson
International Journal of Molecular Sciences - 2024 -
Lemur tail kinase 3 serves as a predictor of patient outcomes and a target for the treatment of ovarian
cancer
Ghassan M. Saed, Nicole M. Fletcher, Harvey Sharma, Axel Stenmark Tullberg, Ella Ittner, Toshima Z Parris, Daniella Pettersson, Aniko Kovacs, Elisabeth Werner Rönnerman, Pernilla Dahm-Kähler, Anna Portela, Pamela D. Garzone, Robert Morris, Khalil Helou
MOLECULAR THERAPY ONCOLOGY - 2024 -
Multi-omics analysis identifies repurposing bortezomib in the treatment of kidney-, nervous system-, and hematological
cancers
Peter Larsson, Maxim Olsson, Sithumini Sarathchandra, Anna Fäldt Beding, Eva Forssell-Aronsson, Anikó Kovács, Per Karlsson, Khalil Helou, Toshima Z Parris
Scientific Reports - 2024 -
Digital RNA sequencing using unique molecular identifiers enables ultrasensitive RNA mutation
analysis
Manuel Luna Santa-María, Daniel Andersson, Toshima Z Parris, Khalil Helou, Tobias Österlund, Anders Ståhlberg
COMMUNICATIONS BIOLOGY - 2024 -
Integrated transcriptomics- and structure-based drug repositioning identifies drugs with proteasome inhibitor
properties
Peter Larsson, MC Rosa, Benedetta Righino, Maxim Olsson, Bogdan Iulius Florea, Eva Forssell-Aronsson, Anikó Kovács, Per Karlsson, Khalil Helou, Toshima Z Parris
Scientific Reports - 2024 -
Late age- and dose-related effects on the proteome of thyroid tissue in rats after 131I
exposure.
Malin Druid, Emman Shubbar, Johan Spetz, Toshima Z Parris, Britta Langen, Charlotte Ytterbrink, Evelin Berger, Khalil Helou, Eva Forssell-Aronsson
Radiation - 2024 -
Repurposing proteasome inhibitors for improved treatment of triple-negative breast
cancer
Peter Larsson, Daniella Pettersson, Maxim Olsson, Sithumini Sarathchandra, Alexandra Abramsson, Henrik Zetterberg, Ella Ittner, Eva Forssell-Aronsson, Anikó Kovács, Per Karlsson, Khalil Helou, Toshima Z Parris
Cell death discovery - 2024 -
Clinical relevance of biomarker discordance between primary breast cancers and synchronous axillary lymph node
metastases.
Slavica Janeva, Toshima Z Parris, Ellen Krabbe, Marie Sundquist, Per Karlsson, Riccardo A Audisio, Roger Olofsson, Anikó Kovács
Clinical & experimental metastasis - 2023 -
Cancer stem cells are prevalent in the basal-like 2 and mesenchymal triple-negative breast cancer subtypes in
vitro
Maxim Olsson, Peter Larsson, Junko Johansson, Vasu R. Sah, Toshima Z Parris
Frontiers in Cell and Developmental Biology - 2023 -
Clinical evaluation of molecular surrogate subtypes in patients with ipsilateral multifocal primary breast
cancer
Slavica Janeva, E. Krabbe, Toshima Z Parris, Salmir Nasic, M. Sundquist, Per Karlsson, Riccardo A Audisio, Roger Olofsson Bagge, Anikó Kovács
Breast Cancer Research - 2023 -
Optimization of Cell Viability Assays for Drug Sensitivity
Screens.
Peter Larsson, Toshima Z Parris
Methods in molecular biology (Clifton, N.J.) Vol. 2644 - 2023 -
Age-related long-term response in rat thyroid tissue and plasma after internal low dose exposure to
I-131
Malin Larsson, Nils Rudqvist, Johan Spetz, Toshima Z Parris, Britta Langen, Khalil Helou, Eva Forssell-Aronsson
Scientific Reports - 2022 -
Pan-cancer analysis of genomic and transcriptomic data reveals the prognostic relevance of human proteasome genes in different cancer
types.
Peter Larsson, Daniella Pettersson, Hanna Engqvist, Elisabeth Werner Rönnerman, Eva Forssell-Aronsson, Anikó Kovács, Per Karlsson, Khalil Helou, Toshima Z Parris
BMC cancer - 2022 -
Trefoil factor family proteins as potential diagnostic markers for mucinous invasive ovarian
carcinoma.
Elisabeth Werner Rönnerman, Daniella Pettersson, Szilard Nemes, Pernilla Dahm-Kähler, Anikó Kovács, Per Karlsson, Toshima Z Parris, Khalil Helou
Frontiers in oncology - 2022 -
Pan-cancer analysis identifies BIRC5 as a prognostic
biomarker.
Anna Fäldt Beding, Peter Larsson, Khalil Helou, Zakaria Einbeigi, Toshima Z Parris
BMC Cancer - 2022 -
Comparison of breast cancer surrogate subtyping using a closed-system RT-qPCR breast cancer assay and immunohistochemistry on 100 core needle biopsies with matching surgical
specimens.
Slavica Janeva, Toshima Z Parris, Salmir Nasic, Shahin De Lara, Karolina Larsson, Riccardo A Audisio, Roger Olofsson, Anikó Kovács
BMC Cancer - 2021 -
Prognostic Significance of BIRC5/Survivin in Breast Cancer: Results from Three Independent
Cohorts.
Nina Oparina, Malin Erlandsson, Anna Fäldt Beding, Toshima Z Parris, Khalil Helou, Per Karlsson, Zakaria Einbeigi, Maria Bokarewa
Cancers - 2021 -
Genetic alterations associated with multiple primary
malignancies.
Jenny Nyqvist-Streng, Anikó Kovács, Zakaria Einbeigi, Per Karlsson, Eva Forssell-Aronsson, Khalil Helou, Toshima Z Parris
Cancer medicine - 2021 -
Long-term transcriptomic and proteomic effects in Sprague Dawley rat thyroid and plasma after internal low dose 131I
exposure.
Malin Larsson, Nils Rudqvist, Johan Spetz, Emman Shubbar, Toshima Z Parris, Britta Langen, Khalil Helou, Eva Forssell-Aronsson
PloS one - 2020 -
Adjuvant chemotherapy and survival in women aged 70 years and older with triple-negative breast cancer: a Swedish population-based propensity score-matched
analysis
Slavica Janeva, Chenyang Zhang, Anikó Kovács, Toshima Z Parris, Jennifer A. Crozier, Christopher M. Pezzi, Barbro Linderholm, Riccardo A Audisio, Roger Olofsson Bagge
The Lancet Healthy Longevity - 2020 -
Integrative genomics approach identifies molecular features associated with early-stage ovarian carcinoma
histotypes.
Hanna Engqvist, Toshima Z Parris, Jana Biermann, Elisabeth Werner Rönnerman, Peter Larsson, Karin Sundfeldt, Anikó Kovács, Per Karlsson, Khalil Helou
Scientific reports - 2020 -
Optimization of cell viability assays to improve replicability and reproducibility of cancer drug sensitivity
screens.
Peter Larsson, Hanna Engqvist, Jana Biermann, Elisabeth Werner Rönnerman, Eva Forssell-Aronsson, Anikó Kovács, Per Karlsson, Khalil Helou, Toshima Z Parris
Scientific Reports - 2020 -
A 17-marker panel for global genomic instability in breast
cancer.
Jana Biermann, Szilárd Nemes, Toshima Z Parris, Hanna Engqvist, Elisabeth Werner Rönnerman, Anikó Kovács, Per Karlsson, Khalil Helou
Genomics - 2020 -
Male Breast Carcinoma after Irradiation and Long-Term Phenothiazine Exposure: A Case
Report
Ragnar Hultborn, Toshima Z Parris, Khalil Helou, Åke Borg, Shahin De Lara
Case Reports in Oncology - 2020 -
Previously diagnosed multiple primary malignancies in patients with breast carcinoma in Western Sweden between 2007 and
2018.
Jenny Nyqvist-Streng, Toshima Z Parris, Khalil Helou, Elisabeth Kenne Sarenmalm, Zakaria Einbeigi, Per Karlsson, Salmir Nasic, Anikó Kovács
Breast cancer research and treatment - 2020 -
Validation of Novel Prognostic Biomarkers for Early-Stage Clear-Cell, Endometrioid and Mucinous Ovarian Carcinomas Using
Immunohistochemistry
Hanna Engqvist, Toshima Z Parris, A. Kovacs, Elisabeth Werner Rönnerman, Karin Sundfeldt, Per Karlsson, Khalil Helou
Frontiers in Oncology - 2020 -
Pan-cancer analyses of human nuclear receptors reveal transcriptome diversity and prognostic value across cancer
types
Toshima Z Parris
Scientific Reports - 2020 -
Identification of candidate genetic variants and altered protein expression in neural stem and mature neural cells support altered microtubule function to be an essential component in bipolar
disorder
Katarina Truvé, Toshima Z Parris, Dzeneta Vizlin-Hodzic, Susanne Salmela, Evelin Berger, Hans Ågren, Keiko Funa
Translational Psychiatry - 2020 -
Proteomic expression analysis of rat thyroid tissue 12 months after low-intermediate 131I
exposure
Malin Larsson, Emman Shubbar, Johan Spetz, Britta Langen, Toshima Z Parris, Khalil Helou, Eva Forssell-Aronsson
ERRS 2020 - 2020 -
Breast Implant-Associated Anaplastic Large Cell Lymphoma (BIA-ALCL) - Case
Report
Slavica Janeva, Ulrika Hansson, Susanne Bram Ednersson, Balázs Márton, Khalil Helou, Toshima Z Parris, Håkan Hallberg, Anikó Kovács
Annals of Clinical and Medical Case Reports - 2020 -
Radiation-induced genomic instability in breast carcinomas of the Swedish haemangioma
cohort.
Jana Biermann, Britta Langen, Szilard Nemes, Erik Holmberg, Toshima Z Parris, Elisabeth Werner Rönnerman, Hanna Engqvist, Anikó Kovács, Khalil Helou, Per Karlsson
Genes, chromosomes & cancer - 2019 -
Immunohistochemical validation of COL3A1, GPR158 and PITHD1 as prognostic biomarkers in early-stage ovarian
carcinomasn
Hanna Engqvist, Toshima Z Parris, Anikó Kovács, Szilard Nemes, Elisabeth Werner Rönnerman, Shahin De Lara, Jana Biermann, Karin Sundfeldt, Per Karlsson, Khalil Helou
BMC Cancer - 2019 -
Transcriptional effects of Lu-177-octreotate therapy using a priming treatment schedule on GOT1 tumor in nude
mice
Johan Spetz, Britta Langen, Nils Rudqvist, Toshima Z Parris, Emman Shubbar, Johanna Dalmo, Bo Wängberg, Ola Nilsson, Khalil Helou, Eva Forssell-Aronsson
Ejnmmi Research - 2019 -
The prognostic relevance of FOXA1 and Nestin expression in breast cancer metastases: a retrospective study of 164 cases during a 10-year period
(2004-2014)
Shahin De Lara, Jenny Nyqvist-Streng, Elisabeth Werner Rönnerman, Khalil Helou, E. K. Sarenmalm, Zakaria Einbeigi, Per Karlsson, Toshima Z Parris, Anikó Kovács
Bmc Cancer - 2019 -
Tumorigenic effects of TLX over-expression in HEK 293T
cells
Toshima Z Parris, Dzeneta Vizlin-Hodzic, Susanne Salmela, Keiko Funa
Cancer Reports - 2019 -
Tumour clonality in paired invasive breast
carcinomas
Jana Biermann, Toshima Z Parris, Szilard Nemes, Anna Danielsson, Hanna Engqvist, Elisabeth Werner Rönnerman, Eva Forssell-Aronsson, Anikó Kovács, Per Karlsson, Khalil Helou
Cancer Research - 2019 -
Design and creation of a wearable circular ultrasonic device for a soft screening and diagnosis of breast
abnormalities
Amira Godih, Georges Nassar, Toshima Z Parris, Nadine Saad, Elie Helou, Per Karlsson, Khalil Helou
J Cancer Sci Clin Ther - 2019 -
Long-term effects in thyroid and plasma
after internal low dose exposure with 131I in
rat
Malin Larsson, Nils Rudqvist, Johan Spetz, Toshima Z Parris, Britta Langen, Khalil Helou, Eva Forssell-Aronsson
Gothenburg Cancer Meeting - 2019 -
Low-dose exposure of 131I in young rat thyroid tissue and
plasma
Malin Larsson, Nils Rudqvist, Johan Spetz, Toshima Z Parris, Britta Langen, Khalil Helou, Eva Forssell-Aronsson
European Radiation Protection Week - 2019 -
Transcriptomic and genomic profiling of early-stage ovarian carcinomas associated with histotype and overall
survival
Hanna Engqvist, Toshima Z Parris, Elisabeth Werner Rönnerman, Elin Söderberg, Jana Biermann, Constantina Mateoiu, Karin Sundfeldt, Anikó Kovács, Per Karlsson, Khalil Helou
Oncotarget - 2018 -
Genome-wide multi-omics profiling of the 8p11-p12 amplicon in breast
carcinoma.
Toshima Z Parris, Elisabeth Werner Rönnerman, Hanna Engqvist, Jana Biermann, Katarina Truvé, Szilard Nemes, Eva Forssell-Aronsson, Giovanni Solinas, Anikó Kovács, Per Karlsson, Khalil Helou
Oncotarget - 2018 -
GATA3 as a putative marker of breast cancer metastasis-A retrospective immunohistochemical
study.
Shahin De Lara, Toshima Z Parris, Elisabeth Werner Rönnerman, Khalil Helou, Anikó Kovács
The breast journal - 2018 -
Clonal relatedness in tumour pairs of breast cancer
patients.
Jana Biermann, Toshima Z Parris, Szilard Nemes, Anna Danielsson, Hanna Engqvist, Elisabeth Werner Rönnerman, Eva Forssell-Aronsson, Anikó Kovács, Per Karlsson, Khalil Helou
Breast cancer research : BCR - 2018 -
Time-dependent transcriptional response of GOT1 human small intestine neuroendocrine tumor after 177Lu-octreotate
therapy
Johan Spetz, Nils Rudqvist, Britta Langen, Toshima Z Parris, Johanna Dalmo, Emil Schüler, Bo Wängberg, Ola Nilsson, Khalil Helou, Eva Forssell-Aronsson
Nuclear Medicine and Biology - 2018
More publications
We have limited the number of publications on this page. Visit GUP (The Publication Database for Gothenburg University) to find more publications.