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Johan Spetz
Researcher
Department of Medical Radiation Sciences-
Early proteomic response in thyroid gland after 131I administration in female Balb/c
mice
Nils Rudqvist, Johan Spetz, Emil Schüler, Toshima Parris, Britta Langen, Carina Sihlbom Wallem, Khalil Helou, Eva Forssell-Aronsson
RADIATION PROTECTION DOSIMETRY - 2025 -
Short and long-term effects on the thyroid proteome after <SUP>131</SUP>I
exposure
Klara Linnea Insulander Björk, Britta Langen, Anja Schroff, Emman Shubbar, Khalil Helou, Johan Spetz, Eva Forssell-Aronsson
RADIATION PROTECTION DOSIMETRY - 2025 -
Evaluation of coadministration schedules of rA1M for kidney protection after administration of
<SUP>177</SUP>Lu-octreotide
Nishte Rassol, Charlotte Ytterbrink, Daniella Pettersson, Amin Al-Awar, Hana Bakr, Magnus Gram, Johan Spetz, Eva Forssell-Aronsson
RADIATION PROTECTION DOSIMETRY - 2025 -
Late apoptotic effects after treatment with 177Lu-octreotate in small-intestine neuroendocrine GOT1 tumor
model
Mikael Elvborn, Nishte Rassol, Daniella Pettersson, Emman Shubbar, Johan Spetz, Khalil Helou, Eva Forssell-Aronsson
International Journal of Radiation Biology - 2025 -
Age-dependent gene expression in rat thyroids 12 months following low-dose ¹³¹I
exposure
Anja Schroff, Malin Druid, Emman Shubbar, Hugo Swenson, Ella Ittner, Khalil Helou, Johan Spetz, Eva Forssell-Aronsson
7th Swedish Cancer Research Meeting, 2025, Malmö, Sweden - 2025 -
A window-of-opportunity trial reveals mechanisms of response and resistance to navtemadlin in patients with recurrent
glioblastoma
Veronica Rendo, Eudocia Q. Lee, Connor Bossi, Nicholas Khuu, Michelle A. Rudek, Sangita Pal, Narmen Azazmeh, Rumana Rashid, Jia-Ren Lin, Margaret Cusick, Abigail R. N. Reynolds, Auriole C. R. Fassinou, Georges Ayoub, Seth Malinowski, Emily Lapinskas, William Pisano, John Jeang, Sylwia A. Stopka, Michael S. Regan, Johan Spetz, Arati Desai, Frank Lieberman, Kamalakannan Palanichamy, Joy D. Fisher, Kristine Pelton, Raymond Y. Huang, Kristopher A. Sarosiek, Louis B. Nabors, Matthias Holdhoff, Neeraja Danda, Roy Strowd, Serena Desideri, Tobias Walbert, Xiaobu Ye, Arnab Chakravarti, Peter K. Sorger, Sandro Santagata, Nathalie Y. R. Agar, Stuart A. Grossman, Brian M. Alexander, Patrick Y. Wen, Keith L. Ligon, Rameen Beroukhim
SCIENCE TRANSLATIONAL MEDICINE - 2025 -
Age and biological sex influences the biodistribution and dosimetry of ¹³¹I in Sprague-Dawley
rats.
Anja Schroff, Klara Insulander Björk, Nishte Rassol, Julia Johansson, Torgny Lundberg, Hana Bakr, Martin Andersson, Johan Spetz, Eva Forssell-Aronsson
European Radiation Protection Week, 2024, Rome, Italy - 2024 -
Biodistribution and dosimetry of ¹³¹I in rats are influenced by age at exposure and biological
sex.
Anja Schroff, Klara Insulander Björk, Nishte Rassol, Julia Johansson, Torgny Lundberg, Hana Bakr, Martin Andersson, Johan Spetz, Eva Forssell-Aronsson
48th European Radiation Research Society Meeting, 2024, Aveiro, Portugal - 2024 -
Late age- and dose-related effects on the proteome of thyroid tissue in rats after 131I
exposure.
Malin Druid, Emman Shubbar, Johan Spetz, Toshima Z Parris, Britta Langen, Charlotte Ytterbrink, Evelin Berger, Khalil Helou, Eva Forssell-Aronsson
Radiation - 2024 -
Synergistic antitumor effects of Lorlatinib and 177Lu-octreotide combination treatment in a high-risk neuroblastoma xenograft mouse
model
Arman Romiani, Daniella Pettersson, Klara Simonsson, Hana Bakr, Dan E. Lind, Anikó Kovács, Johan Spetz, Ruth H. Palmer, Bengt Hallberg, Khalil Helou, Eva Forssell-Aronsson
Therapeutics - 2024 -
Comparison of 177Lu-octreotate and 177Lu-octreotide for treatment in human neuroblastoma-bearing
mice
Arman Romiani, Klara Simonsson, Daniella Pettersson, Amin Al-awar, Nishte Rassol, Hana Bakr, Dan E. Lind, Ganesh Umapathy, Johan Spetz, Ruth H. Palmer, Bengt Hallberg, Khalil Helou, Eva Forssell-Aronsson
Heliyon - 2024 -
Radiotherapy-Induced Neurocognitive Impairment Is Driven by Heightened Apoptotic Priming in Early Life and Prevented by Blocking
BAX.
Rumani Singh, Stacey Yu, Marwa Osman, Zintis Inde, Cameron Fraser, Abigail H Cleveland, Nicole Almanzar, Chuan Bian Lim, Gaurav N Joshi, Johan Spetz, Xingping Qin, Sneh M Toprani, Zachary Nagel, Matthew C Hocking, Robert A Cormack, Torunn I Yock, Jeffrey W Miller, Zhi-Min Yuan, Timothy Gershon, Kristopher A Sarosiek
Cancer research - 2023 -
Targeting TBK1 to overcome resistance to cancer
immunotherapy.
Yi Sun, Or-Yam Revach, Seth Anderson, Emily A Kessler, Clara H Wolfe, Anne Jenney, Caitlin E Mills, Emily J Robitschek, Thomas G R Davis, Sarah Kim, Amina Fu, Xiang Ma, Jia Gwee, Payal Tiwari, Peter P Du, Princy Sindurakar, Jun Tian, Arnav Mehta, Alexis M Schneider, Keren Yizhak, Moshe Sade-Feldman, Thomas LaSalle, Tatyana Sharova, Hongyan Xie, Shuming Liu, William A Michaud, Rodrigo Saad-Beretta, Kathleen B Yates, Arvin Iracheta-Vellve, Johan Spetz, Xingping Qin, Kristopher A Sarosiek, Gao Zhang, Jong Wook Kim, Mack Y Su, Angelina M Cicerchia, Martin Q Rasmussen, Samuel J Klempner, Dejan Juric, Sara I Pai, David M Miller, Anita Giobbie-Hurder, Jonathan H Chen, Karin Pelka, Dennie T Frederick, Susanna Stinson, Elena Ivanova, Amir R Aref, Cloud P Paweletz, David A Barbie, Debattama R Sen, David E Fisher, Ryan B Corcoran, Nir Hacohen, Peter K Sorger, Keith T Flaherty, Genevieve M Boland, Robert T Manguso, Russell W Jenkins
Nature - 2023 -
Age-related long-term response in rat thyroid tissue and plasma after internal low dose exposure to
I-131
Malin Larsson, Nils Rudqvist, Johan Spetz, Toshima Z Parris, Britta Langen, Khalil Helou, Eva Forssell-Aronsson
Scientific Reports - 2022 -
Heightened apoptotic priming of vascular cells across tissues and life span predisposes them to cancer therapy-induced
toxicities.
Johan Spetz, Mary H C Florido, Cameron S Fraser, Xingping Qin, Jonathan Choiniere, Stacey J Yu, Rumani Singh, Max Friesen, Lee L Rubin, Joe-Elie Salem, Javid J Moslehi, Kristopher A Sarosiek
Science advances - 2022 -
Exploiting endogenous and therapy-induced apoptotic vulnerabilities in immunoglobulin light chain amyloidosis with BH3
mimetics.
Cameron S Fraser, Johan Spetz, Xingping Qin, Adam Presser, Jonathan Choiniere, Chendi Li, Stacey Yu, Frances Blevins, Aaron N Hata, Jeffrey W Miller, Gary A Bradshaw, Marian Kalocsay, Vaishali Sanchorawala, Shayna Sarosiek, Kristopher A Sarosiek
Nature communications - 2022 -
Age and sex effects across the blood proteome after ionizing radiation exposure can bias biomarker screening and risk
assessment
Britta Langen, Egor Vorontsov, Johan Spetz, J. Swanpalmer, Carina Sihlbom, Khalil Helou, Eva Forssell-Aronsson
Scientific Reports - 2022 -
Age-dependent regulation of SARS-CoV-2 cell entry genes and cell death programs correlates with COVID-19
severity.
Zintis Inde, Ben A Croker, Clarence Yapp, Gaurav N Joshi, Johan Spetz, Cameron Fraser, Xingping Qin, Le Xu, Brian Deskin, Elisa Ghelfi, Gabrielle Webb, Aaron F Carlin, Yanfang Peipei Zhu, Sandra L Leibel, Aaron F Garretson, Alex E Clark, Jason M Duran, Victor Pretorius, Laura E Crotty-Alexander, Chendi Li, Jamie Casey Lee, Chhinder Sodhi, David J Hackam, Xin Sun, Aaron N Hata, Lester Kobzik, Jeffrey Miller, Jin-Ah Park, Douglas Brownfield, Hongpeng Jia, Kristopher A Sarosiek
Science advances - 2021 -
Metabolic perturbations sensitize triple-negative breast cancers to apoptosis induced by BH3
mimetics.
Veerle W Daniels, Jason J Zoeller, Nick van Gastel, Kelley E McQueeney, Salma Parvin, Danielle S Potter, Geoffrey G Fell, Vinícius G Ferreira, Binyam Yilma, Rajat Gupta, Johan Spetz, Patrick D Bhola, Jennifer E Endress, Isaac S Harris, Emanuel Carrilho, Kristopher A Sarosiek, David T Scadden, Joan S Brugge, Anthony Letai
Science signaling - 2021 -
Neuroblastoma xenograft models demonstrate the therapeutic potential of
Lu-177-octreotate
Arman Romiani, Johan Spetz, Emman Shubbar, Dan E. Lind, Bengt Hallberg, Ruth H. Palmer, Eva Forssell-Aronsson
BMC Cancer - 2021 -
Preface: Life through death-Key role of cellular suicide for colonial and organismal
homeostasis.
Johan Spetz, Lorenzo Galluzzi
International review of cell and molecular biology - 2020 -
Preface: Life through death-Key role of cellular suicide for colonial and organismal
homeostasis.
Johan Spetz, Lorenzo Galluzzi
International review of cell and molecular biology - 2020 -
Preface: Life through death-Key role of cellular suicide for colonial and organismal
homeostasis.
Johan Spetz, Lorenzo Galluzzi
International review of cell and molecular biology - 2020 -
Long-term transcriptomic and proteomic effects in Sprague Dawley rat thyroid and plasma after internal low dose 131I
exposure.
Malin Larsson, Nils Rudqvist, Johan Spetz, Emman Shubbar, Toshima Z Parris, Britta Langen, Khalil Helou, Eva Forssell-Aronsson
PloS one - 2020 -
Biodistribution of I-131 in mice is influenced by circadian
variations
Charlotte Andersson, Mikael Elvborn, Johan Spetz, Britta Langen, Eva Forssell-Aronsson
Scientific Reports - 2020 -
Increased therapeutic effect on medullary thyroid cancer using a combination of radiation and tyrosine kinase
inhibitors
Viktor Sandblom, Johan Spetz, Emman Shubbar, Mikael Montelius, Ingun Ståhl, John Swanpalmer, Ola Nilsson, Eva Forssell-Aronsson
PLoS ONE - 2020 -
Proteomic expression analysis of rat thyroid tissue 12 months after low-intermediate 131I
exposure
Malin Larsson, Emman Shubbar, Johan Spetz, Britta Langen, Toshima Z Parris, Khalil Helou, Eva Forssell-Aronsson
ERRS 2020 - 2020 -
T Cells and Regulated Cell Death: Kill or Be
Killed.
Johan Spetz, Adam G Presser, Kristopher A Sarosiek
International review of cell and molecular biology - 2019 -
Transcriptional effects of Lu-177-octreotate therapy using a priming treatment schedule on GOT1 tumor in nude
mice
Johan Spetz, Britta Langen, Nils Rudqvist, Toshima Z Parris, Emman Shubbar, Johanna Dalmo, Bo Wängberg, Ola Nilsson, Khalil Helou, Eva Forssell-Aronsson
Ejnmmi Research - 2019 -
Gemcitabine potentiates the anti-tumour effect of radiation on medullary thyroid
cancer.
Viktor Sandblom, Johan Spetz, Emman Shubbar, Mikael Montelius, Ingun Ståhl, John Swanpalmer, Ola Nilsson, Eva Forssell-Aronsson
PloS One - 2019 -
Multiparametric MR for non-invasive evaluation of tumour tissue histological characteristics after radionuclide
therapy.
Mikael Montelius, Oscar Jalnefjord, Johan Spetz, Ola Nilsson, Eva Forssell-Aronsson, Maria Ljungberg
NMR in biomedicine - 2019 -
Tyrosine kinase inhibitors can potentially increase the effect from radiation therapy on medullary thyroid
cancer
Viktor Sandblom, Johan Spetz, Emman Shubbar, Mikael Montelius, Ingun Ståhl, John Swanpalmer, Ola Nilsson, Eva Forssell-Aronsson
Gothenburg Cancer Meeting. 6-7th May 2019 - 2019 -
Tyrosinkinashämmare kan öka effekten från strålbehandling av medullär
tyreoideacancer
Viktor Sandblom, Johan Spetz, Emman Shubbar, Mikael Montelius, Ingun Ståhl, John Swanpalmer, Ola Nilsson, Eva Forssell-Aronsson
Nationellt möte om sjukhusfysik - 2019 -
Long-term effects in thyroid and plasma
after internal low dose exposure with 131I in
rat
Malin Larsson, Nils Rudqvist, Johan Spetz, Toshima Z Parris, Britta Langen, Khalil Helou, Eva Forssell-Aronsson
Gothenburg Cancer Meeting - 2019 -
Low-dose exposure of 131I in young rat thyroid tissue and
plasma
Malin Larsson, Nils Rudqvist, Johan Spetz, Toshima Z Parris, Britta Langen, Khalil Helou, Eva Forssell-Aronsson
European Radiation Protection Week - 2019 -
Chronotherapy: a possible way to optimze 131I-based
therapy?
Charlotte Andersson, Mikael Elvborn, Johan Spetz, Britta Langen, Eva Forssell-Aronsson
European Radiation Protection Week, Stockholm, Sweden, 2019, 14-18 October - 2019 -
Radiolabeled somatostatin analogue binding and internalization in human tumor cell
lines
Sofia Saadati, Johan Spetz, Viktor Sandblom, Emil Schüler, Ruth H. Palmer, Bengt Hallberg, Khalil Helou, Eva Forssell-Aronsson
Gothenburg Cancer Meeting 2019, Gothenburg, Sweden - 2019 -
Radiation-Induced Cardiovascular Toxicity: Mechanisms, Prevention, and
Treatment.
Johan Spetz, Javid Moslehi, Kristopher Sarosiek
Current treatment options in cardiovascular medicine - 2018 -
Comparison of in vivo MRS and ex vivo HR-MAS MRS for assessment of metabolite content in the GOT1 small intestine neuroendocrine tumour
model
Mikael Montelius, Johan Spetz, Diana Bernin, Oscar Jalnefjord, Maria Ljungberg, Eva Forssell-Aronsson
Joint Annual Meeting ISMRM-ESMRMB, 26-21 June 2018, Paris - 2018 -
Molecular targeting of various human tumor cell lines with
177Lu-octreotate
Sofia Saadati, Johan Spetz, Viktor Sandblom, Emil Schüler, Ruth H. Palmer, Bengt Hallberg, Khalil Helou, Eva Forssell-Aronsson
Annual Congress of the European Association of Nuclear Medicine October 13 - 17, 2018 Düsseldorf, Germany - 2018 -
Vandetanib may act as radiosensitiser for 177Lu-octreotate treatment of medullary thyroid
cancer
Viktor Sandblom, Johan Spetz, Emman Shubbar, Ingun Ståhl, John Swanpalmer, Eva Forssell-Aronsson
2nd European Congress of Medical Physics. Physica Medica Vol. 52, Suppl. 1, pp. 62-63 - 2018 -
Deconvolution of expression microarray data reveals I-131-induced responses otherwise undetected in thyroid
tissue
Britta Langen, Nils Rudqvist, Johan Spetz, Khalil Helou, Eva Forssell-Aronsson
Plos One - 2018 -
Radiation biomarker screening in blood plasma: the relevance of age and sex
bias
Britta Langen, Johan Spetz, John Swanpalmer, Carina Sihlbom, Khalil Helou, Eva Forssell-Aronsson
64th Annual Meeting of the Radiation Research Society, Chicago, IL, USA, Sep 23–26, 2018. - 2018 -
Better therapeutic results after fractionated administration of Lu-177-octreotate in mice bearing human
neuroblastoma
Arman Romiani, Johan Spetz, Emman Shubbar, Ruth H. Palmer, Bengt Hallberg, Eva Forssell-Aronsson
The European Association of Nuclear Medicine (EANM) - 2018 -
Optimization of treatment of neuroendocrine tumors with radiolabeled somatostatin
analogues
Eva Forssell-Aronsson, Johan Spetz, Viktor Sandblom, Britta Langen, Khalil Helou, Bo Wängberg, Ola Nilsson
Global Academics Programs Conference, Stockholm, May 15-17, 2018. - 2018 -
Time-dependent transcriptional response of GOT1 human small intestine neuroendocrine tumor after 177Lu-octreotate
therapy
Johan Spetz, Nils Rudqvist, Britta Langen, Toshima Z Parris, Johanna Dalmo, Emil Schüler, Bo Wängberg, Ola Nilsson, Khalil Helou, Eva Forssell-Aronsson
Nuclear Medicine and Biology - 2018 -
Identification of Potential MR-Derived Biomarkers for Tumor Tissue Response to 177Lu-Octreotate Therapy in an Animal Model of Small Intestine Neuroendocrine
Tumor.
Mikael Montelius, Johan Spetz, Oscar Jalnefjord, Evelin Berger, Ola Nilsson, Maria Ljungberg, Eva Forssell-Aronsson
Translational oncology - 2018 -
Transcriptional response to 131I exposure of rat thyroid
gland
Nils Rudqvist, Johan Spetz, Emil Schüler, Toshima Z Parris, Britta Langen, Khalil Helou, Eva Forssell-Aronsson
PLoS ONE - 2017 -
Hedgehog inhibitor sonidegib potentiates 177Lu-octreotate therapy of GOT1 human small intestine neuroendocrine tumors in nude
mice
Johan Spetz, Britta Langen, Nils Rudqvist, Toshima Z Parris, Khalil Helou, Ola Nilsson, Eva Forssell-Aronsson
BMC Cancer - 2017 -
Priming increases the anti-tumor effect and therapeutic window of 177Lu-octreotate in nude mice bearing human small intestine neuroendocrine tumor
GOT1.
Johanna Dalmo, Johan Spetz, Mikael Montelius, Britta Langen, Yvonne Arvidsson, Henrik Johansson, Toshima Z Parris, Khalil Helou, Bo Wängberg, Ola Nilsson, Maria Ljungberg, Eva Forssell-Aronsson
EJNMMI Research - 2017
More publications
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