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Alexandra Abramsson
Researcher
Department of Psychiatry andAbout Alexandra Abramsson
My research focuses on understanding the function of the APP (amyloid precursor protein) family proteins in development, aging and disease. For this purpose, I use zebrafish and in vitro cell cultures to study molecular and cellular changes associated with APP. I'm interested in addressing the role of APP in various cilia, in the migration and guidance of neuronal cells and how this contributes to shape the sensory perception and behavior in the zebrafish.
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Repurposing proteasome inhibitors for improved treatment of triple-negative breast
cancer
Peter Larsson, Daniella Pettersson, Maxim Olsson, Sithumini Sarathchandra, Alexandra Abramsson, Henrik Zetterberg, Ella Ittner, Eva Forssell-Aronsson, Anikó Kovács, Per Karlsson, Khalil Helou, Toshima Z Parris
Cell death discovery - 2024 -
The localization of amyloid precursor protein to ependymal cilia in vertebrates and its role in ciliogenesis and brain development in
zebrafish
Jasmine Chebli, Maryam Rahmati, T. Lashley, Brigitta Edeman, Anders Oldfors, Henrik Zetterberg, Alexandra Abramsson
Scientific Reports - 2021 -
Amyloid precursor protein-b facilitates cell adhesion during early development in
zebrafish
Rakesh Kumar Banote, Jasmine Chebli, Tugce Munise Satir, G. K. Varshney, Rafael Camacho, J. Ledin, S. M. Burgess, Alexandra Abramsson, Henrik Zetterberg
Scientific Reports - 2020 -
Cell stemness is maintained upon concurrent expression of RB and the mitochondrial ribosomal protein
S18-2
M. Mushtaq, L. Kovalevska, S. Darekar, Alexandra Abramsson, Henrik Zetterberg, V. Kashuba, G. Klein, M. Arsenian-Henriksson, E. Kashuba
Proceedings of the National Academy of Sciences of the United States of America - 2020 -
Cardiomyopathy with lethal arrhythmias associated with inactivation of
KLHL24
Carola Oldfors Hedberg, Alexandra Abramsson, D. P. S. Osborn, O. Danielsson, A. Fazlinezhad, Y. Nilipour, L. Hubbert, I. Nennesmo, Kittichate Visuttijai, J. Bharj, E. Petropoulou, A. Shoreim, B. Vona, N. Ahangari, Marcela Davila Lopez, M. Doosti, Rakesh Kumar Banote, R. Maroofian, Malin Edling, M. Taherpour, Henrik Zetterberg, E. G. Karimiani, Anders Oldfors, Y. Jamshidi
Human Molecular Genetics - 2019 -
beta-Amyloid precursor protein-b is essential for Mauthner cell development in the zebrafish in a Notch-dependent
manner
Rakesh Kumar Banote, Malin Edling, F. Eliassen, Petronella Kettunen, Henrik Zetterberg, Alexandra Abramsson
Developmental Biology - 2016 -
EPHA2 polymorphisms in Estonian patients with age-related
cataract.
Dragana Celojevic, Alexandra Abramsson, Mona Seibt Palmér, Gunnar Tasa, Erkki Juronen, Henrik Zetterberg, Madeleine Zetterberg
Ophthalmic genetics - 2016 -
Complement Gene Single Nucleotide Polymorphisms and Biomarker Endophenotypes of Alzheimer's
Disease
Jonny Daborg, Sandra Holmgren, Alexandra Abramsson, Ulf Andreasson, Madeleine Zetterberg, Staffan Nilsson, L Minthon, Ingmar Skoog, Kaj Blennow, Marcela Pekna, Eric Hanse, Henrik Zetterberg
Journal of Alzheimer's Disease - 2013 -
Modulation of dorsal root ganglion development by ErbB signaling and the scaffold protein
Sorbs3.
Sarah J Malmquist, Alexandra Abramsson, Hillary F McGraw, Tor H Linbo, David W Raible
Development (Cambridge, England) - 2013 -
The zebrafish amyloid precursor protein-b is required for motor neuron guidance and synapse
formation.
Alexandra Abramsson, Petronella Kettunen, Rakesh Kumar Banote, Emelie Lott, Mei Li, Anders Arner, Henrik Zetterberg
Developmental biology - 2013 -
SILAC zebrafish for quantitative analysis of protein turnover and tissue
regeneration.
Ann Brinkmalm-Westman, Alexandra Abramsson, Josef Pannee, Chen Gang, Mikael K Gustavsson, Malin von Otter, Kaj Blennow, Gunnar Brinkmalm, Hermann Heumann, Henrik Zetterberg
Journal of proteomics - 2011 -
No association of LOXL1 gene polymorphisms with Alzheimer's
disease.
Alexandra Abramsson, Sara Landgren, Madeleine Zetterberg, Mona Seibt Palmér, Lennart Minthon, Deborah Gustafson, Ingmar Skoog, Kaj Blennow, Henrik Zetterberg
Neuromolecular medicine - 2011 -
Proteomics Profiling of Single Organs from Individual Adult
Zebrafish.
Alexandra Abramsson, Ann Brinkmalm-Westman, Josef Pannee, Mikael K Gustavsson, Malin von Otter, Kaj Blennow, Gunnar Brinkmalm, Petronella Kettunen, Henrik Zetterberg
Zebrafish - 2010 -
Defective N-sulfation of heparan sulfate proteoglycans limits PDGF-BB binding and pericyte recruitment in vascular
development
Alexandra Abramsson, Sindhulakshmi Kurup, Marta Busse, Shuhei Yamada, Per Lindblom, Edith Schallmeiner, Denise Stenzel, Dominique Sauvaget, Johan Ledin, Maria Ringvall, Ulf Landegren, Lena Kjellen, Göran Bondjers, Jin-Ping Li, Ulf Lindahl, Dorothe Spillmann, Christer Betsholtz, Holger Gerhardt
GENES & DEVELOPMENT - 2007 -
Nonradioactive in situ hybridization on frozen sections and whole
mounts.
Julia Asp, Alexandra Abramsson, Christer Betsholtz
Methods in molecular biology (Clifton, N.J.) - 2006 -
Endothelium-specific ablation of PDGFB leads to pericyte loss and glomerular, cardiac and placental
abnormalities
Mattias Bjarnegård, Maria Enge, Jenny Norlin, Sigrun Gustafsdottir, Simon Fredriksson, Alexandra Abramsson, Minoru Takemoto, Erika Gustafsson, Reinhard Fassler, Christer Betsholtz
DEVELOPMENT - 2004 -
Neuropilin-1 is required for endothelial tip cell guidance in the developing central nervous
system
Holger Gerhardt, Christiana Ruhrberg, Alexandra Abramsson, Hajime Fujisawa, David Shima, Christer Betsholtz
Developmental Dynamics - 2004 -
Platelet-derived growth factor production by B16 melanoma cells leads to increased pericyte abundance in tumors and an associated increase in tumor growth
rate
Masao Furuhashi, Tobias Sjöblom, Alexandra Abramsson, Jens Ellingsen, Patrick Micke, Hong Li, Erika Bergsten-Folestad, Ulf Eriksson, Rainer Heuchel, Christer Betsholtz, Carl-Henrik Heldin, Arne Östman
CANCER RESEARCH - 2004 -
Tumor angiogenesis. Regulation of mural cell recruitment and endothelial
sprouting
Alexandra Abramsson
2003 -
Transcription profiling of platelet-derived growth factor-B-deficient mouse embryos identifies RGS5 as a novel marker for pericytes and vascular smooth muscle
cells.
Cecilia Bondjers, Mattias Kalén, Mats Hellström, Stefan Johannes Scheidl, Alexandra Abramsson, Oliver Renner, Per Lindahl, Hyeseon Cho, John Kehrl, Christer Betsholtz
The American journal of pathology - 2003 -
Endothelial PDGF-B retention is required for proper investment of pericytes in the microvessel
wall.
Per Lindblom, Holger Gerhardt, Stefan Liebner, Alexandra Abramsson, Maria Enge, Mats Hellström, Gudrun Bäckström, Simon Fredriksson, Ulf Landegren, Henrik Nyström, Göran Bergström, Elisabetta Dejana, Arne Östman, Per Lindahl, Christer Betsholtz
Genes & development - 2003