University of Gothenburg
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Eva Angenete

Professor/ Chief Physician

Department of
Surgery
Mail
eva.angenete@gu.se
Visiting address
Blå stråket 5, vån 3 su/sahlgrenska
41345 Göteborg
Postal address
Sahlgrenska universitetssjukhuset
41345 Göteborg

About Eva Angenete

Associate professor of surgery

Research area

Colorectal cancer and anal cancer. Focus on surgical treatment, quality of life and health economy. Eva Angenete is a colorectal surgeon with focus on advanced colorectal cancer, anal cancer and minimally invasive methods. She has together with colleages introduced the new technique transanal TME in Sweden (a new method to perform low anastomoses in rectal cancer surgery using laparoscopic technique.

Research environment Eva Angenete worsk in a research group where all clinical studies are performed in a network of Scandinavian academig surgeons (SSORG - The Scandinavian Surgical Outcomes Research Group). She has been a part of the network since the beginning in 2009. The network consists of seven hospitals in Denmark and Sweden with a catchment area of 3 million. Many other hospitals participate in the studies. The goal is to reach expedient accrual, and thus have better control of confounders. Through well established routines an external validity is ascertained.

Background Colorectal cancer represents almost 10 % of all malignant tumours in seden and afflicts more than 6000 individuals yearly. Anal cancer is more uncommon with approximately 120 cases yearly in Sweden. During the last decade the local recurrences in colorectal cancer have decreased and survival has increased. This is probably due to improved diagnostics, surgical technique and additive treatments such as (chemo)radiotherapy. There is still room for improvement as the complication rate after surgical treatment is 26-35%. Many patients also have an impaired quality of life after treatment, which has been increasingly in focus in the last couple of years. The aim of this research program is to evaluate present methods, develop new techniques and identify patients in need of support or help prior, during and after treatment for colorectal and anal cancer. Our goal is to develop better care for a large patient group through detailed studies of surgical and oncological care and treatment.

Some current projects

  1. The anastomosis in colorectal surgery - ColoREG och ANASU During surgery for colorectal cancer an anastomosis is often performed between two bowel ends. A leakage in this anastomosis is a well known serious problem that occurs in 5-10% of all surgeries, and is more comman after rectal cancer surgery. Through studies of registries, smaller cohort studies and quality of life studies the group will identify risk factors, evaluate diagnostic tools and patient experiences.
  2. A temporary diverting stoma for patients with rectal cancer - the EASY and LIV studies To reduce the consequences of an anastomotic leakage the patient may have a diverting loopileostomy. Through several cohort studies the consequences of a loopileostomy itself have been evaluated, and a randomised Scandinavian study will explore the possibilities to have the loopileostomy removed earlier than the standard of often 12 weeks today. The aim is to reduce the total number of complications related to the surgery and the postoperative period.
  3. Complications related to colostomies - the Stoma-Const trial A permanent or temporary colostomy may be necessary for patients with colorectal and anal cancer. A well functioning colostomy may not affect quality of life, but the rate of complications is high. A common (20-70%) complication is parastomal hernia. Colostomy construction is studied in a randomised Scandinavian trial. A cohortstudy evaluating the best type of colostomy is presently underway. The aim is to reduce stoma related complications and to give each patient the perfect stoma.
  4. Quality of life in colorectal cancer - QoLiRECT och QoLiCOL After treatment for colorectal cancer there is an inherent risk of effects on bowel, urinary and sexual function. This may be due to additive treatments, surgical reconstructions or extensive surgery. Some studies indicate that bowel continuity is better than a permanent stoma, but this is contradicted by other studies. Two large longitudinal cohort studies evaluate quality of life at diagnosis and during 3-5 years after diagnosis. The primary aim is to identify areas of improvement and to describe the patients' experiences.
  5. Quality of life in patients with anal cancer - ANCA Anal cancer is often treated with chemoradiotherapy. Sometimes surgery is required due to insufficient response to treatment or due to recurrence. The group studies quality of life in patients with anal cancer with the aim to explore health related quality of life, identify problems and perform interventional studies.
  6. Safety climate in the operating room The safety climate and work environment in the operating room is of utmost important to excel in performance and provide the patient with the best care possible. We study the work enviroment and safety climate in the operating room with the aim to improve teamwork and the surgical results. 

Research group members

Anette Wedin Carina Rosander Carolina Ehrencrona Elin Grybäck Elisabeth González Eva Haglind Hanna Nilsson Ingrid Höglund-Karlsson Jane Heath John Andersson Kajsa Holm Kira Bröndrum Kristoffer Derwinger Mattias Block Ulf Angerås

Current Ph-D students Main supervisor: Adiela Correa Marinez Aron Onerup Bodil Gessler Dan Asplund Jenifer Park Sofia Erestam Associate supervisor: Jacob Gehrman Mattias Prytz

Selected financial support: ALF FoU Västra Götaland Göteborgs Läkaresällskap Cancerfonden Svenska Läkaresällskapet HTA-anslag

Webpage

www.ssorg.net