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Tom Bäck
Researcher
Department of Medical Radiation SciencesAbout Tom Bäck
Research areas: Targeted radionuclide therapy of cancer using alpha-particle emitters. Small-scale dosimetry, Radiobiology, Alpha-particle imaging, therapeutics and pharmacokinetics, renal toxicity, animal models.
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On-site activity determination of 211At using absolute 4pi-alpha liquid scintillation counting and
HPGe
Erik Leidermark, Emma Aneheim, Tom Bäck, Sture Lindegren, H. Jensen, C. Dulieu, X. Mougeot, L. Persson, B. Sabot, Stig Palm
APPLIED RADIATION AND ISOTOPES - 2025 -
211At-Labeled Anti-CD45 Antibody as a Nonmyeloablative Conditioning for Canine DLA-Haploidentical Stem Cell
Transplantation
Sofia H.L. Frost, Johnnie J. Orozco, Tom Bäck, Brian W. Miller, Erlinda B. Santos, Aimee Kenoyer, Sue E. Knoblaugh, Donald K. Hamlin, D. Scott Wilbur, Brenda M. Sandmaier
Journal of nuclear medicine : official publication, Society of Nuclear Medicine - 2024 -
A proposed production method for astatinated (At-211) Trastuzumab for use in a Phase I clinical
trial
Emma Aneheim, Tom Bäck, Holger Jensen, Stig Palm, Sture Lindegren
PLOS ONE - 2024 -
Optimised solid-phase extraction of <SUP>211</SUP>At: Activity balance of <SUP>211</SUP>At, <SUP>210</SUP>At and <SUP>210</SUP>Po after wet chemistry target
dissolution
Matthijs Bart Sevenois, Holger Jan Jensen, Ferid Haddad, Tom Bäck, Matthias D'Huyvetter, Laurent Navarro, Peter Covens
RADIATION PHYSICS AND CHEMISTRY - 2024 -
Modified poly-L-lysine for use as a clearing agent in pretargeted
radioimmunotherapy
Chiara Timperanza, Anna Gustafsson-Lutz, Tom Bäck, Damian J. Green, Sture Lindegren, Emma Aneheim
EJNMMI RADIOPHARMACY AND CHEMISTRY - 2024 -
In vitro and in vivo evaluation of a tetrazine-conjugated poly-L-lysine effector molecule labeled with
astatine-211
Chiara Timperanza, Holger Jensen, Ellinor Hansson, Tom Bäck, Sture Lindegren, Emma Aneheim
EJNMMI RADIOPHARMACY AND CHEMISTRY - 2024 -
A Novel Method for Real-Time Quantification of Radioligand Binding to Living Tumor Cells In
Vitro
Tom Bäck, Per Albertsson, Emma Aneheim, Ragnar Hultborn, Lars Jacobsson, Sture Lindegren, Stig Palm
CANCER BIOTHERAPY AND RADIOPHARMACEUTICALS - 2024 -
Astatine-211 based radionuclide therapy: Current clinical trial
landscape
Per Albertsson, Tom Bäck, Karin Bergmark, Andreas Hallqvist, Mia Johansson, Emma Aneheim, Sture Lindegren, Chiara Timperanza, K. Smerud, Stig Palm
Frontiers in Medicine - 2023 -
Pretargeted Alpha Therapy of Disseminated Cancer Combining Click Chemistry and
Astatine-211
Chiara Timperanza, H. Jensen, Tom Bäck, Sture Lindegren, Emma Aneheim
Pharmaceuticals - 2023 -
Estimating the risk for secondary cancer following targeted alpha therapy with astatine-211 intraperitoneal
radioimmunotherapy.
Erik Leidermark, Andreas Hallqvist, Lars Jacobsson, Per Karlsson, Erik Holmberg, Tom Bäck, Mia Johansson, Sture Lindegren, Stig Palm, Per Albertsson
Journal of nuclear medicine : official publication, Society of Nuclear Medicine - 2022 -
Covalent core-radiolabeling of polymeric micelles with125I/211At for theranostic
radiotherapy
E. Sporer, C. B. M. Poulie, Tom Bäck, Sture Lindegren, H. Jensen, P. J. Kempen, A. Kjaer, M. M. Herth, A. I. Jensen
Nanotheranostics - 2022 -
Radium-223-Induced Bystander Effects Cause DNA Damage and Apoptosis in Disseminated Tumor Cells in Bone
Marrow
B. S. Canter, C. N. Leung, J. C. Fritton, Tom Bäck, D. Rajon, E. I. Azzam, R. W. Howell
Molecular Cancer Research - 2021 -
Evaluation of therapeutic efficacy of 211At-labeled farletuzumab in an intraperitoneal mouse model of disseminated ovarian
cancer
Stig Palm, Tom Bäck, Emma Aneheim, Andreas Hallqvist, Ragnar Hultborn, Lars Jacobsson, H. Jensen, Sture Lindegren, Per Albertsson
Translational Oncology - 2021 -
Modeling bystander effects that cause growth delay of breast cancer xenografts in bone marrow of mice treated with
radium-223
D. A. Rajon, B. S. Canter, C. N. Leung, Tom Bäck, J. C. Fritton, E. I. Azzam, R. W. Howell
International Journal of Radiation Biology - 2021 -
Realizing Clinical Trials with Astatine-211: The Chemistry
Infrastructure
Sture Lindegren, Per Albertsson, Tom Bäck, H. Jensen, Stig Palm, Emma Aneheim
Cancer Biotherapy and Radiopharmaceuticals - 2020 -
Dose-Dependent Growth Delay of Breast Cancer Xenografts in the Bone Marrow of Mice Treated with Ra-223: The Role of Bystander Effects and Their Potential for
Therapy
C. N. Leung, B. S. Canter, D. Rajon, Tom Bäck, J. C. Fritton, E. I. Azzam, R. W. Howell
Journal of Nuclear Medicine - 2020 -
Targeted alpha therapy with astatine-211-labeled anti-PSCA A11 minibody shows antitumor efficacy in prostate cancer xenografts and bone
microtumors
Tom Bäck, Karin Jennbacken, Malin Hagberg Thulin, Sture Lindegren, H. Jensen, T. Olafsen, P. J. Yazaki, Stig Palm, Per Albertsson, Jan-Erik Damber, A. M. Wu, Karin Welén
Ejnmmi Research - 2020 -
Labeling of Anti-HER2 Nanobodies with Astatine-211: Optimization and the Effect of Different Coupling Reagents on Their in Vivo
Behavior
Y. Dekempeneer, Tom Bäck, Emma Aneheim, H. Jensen, J. Puttemans, C. Xavier, M. Keyaerts, Stig Palm, Per Albertsson, T. Lahoutte, V. Caveliers, Sture Lindegren, M. D'Huyvetter
Molecular Pharmaceutics - 2019 -
Intraperitoneal alpha-Emitting Radioimmunotherapy with At-211 in Relapsed Ovarian Cancer: Long-Term Follow-up with Individual Absorbed Dose
Estimations
Andreas Hallqvist, Karin Bergmark, Tom Bäck, Håkan Andersson, Pernilla Dahm-Kähler, Mia Johansson, Sture Lindegren, H. Jensen, Lars Jacobsson, Ragnar Hultborn, Stig Palm, Per Albertsson
Journal of Nuclear Medicine - 2019 -
Astatine-211: The Chemistry
Infrastructure.
Sture Lindegren, Tom Bäck, Stig Palm, Holger Jensen, Per Albertsson, Emma Aneheim
Journal of Medical Imaging and Radiation Sciences - 2019 -
Intraperitoneal Alpha-emitting Radio Immunotherapy with Astatine-211 in Relapsed Ovarian Cancer; Long-term Follow-up with Individual Absorbed Dose
Estimations.
Andreas Hallqvist, Per Albertsson, Ragnar Hultborn, Stig Palm, Karin Bergmark, Tom Bäck, Håkan Andersson, Pernilla Dahm-Kähler, Mia Johansson, Sture Lindegren, Holger Jensen, Lars Jacobsson
Journal of Medical Imaging and Radiation Sciences - 2019 -
Estimation of Long-term Risks for Cancer Induction following Adjuvant Targeted Alpha Therapy with Curative
Intent.
Stig Palm, Andreas Hallqvist, Emma Aneheim, Tom Bäck, Mia Johansson, Ragnar Hultborn, Lars Jacobsson, Sture Lindegren, Per Albertsson
Journal of Medical Imaging and Radiation Sciences - 2019 -
Quantified Cell Binding of Astatinated Immunoconjugates onOvarian Cancer Cell Spheroids by Alpha Camera
Imaging.
Tom Bäck, M Verhoeven, Emma Aneheim, Per Albertsson, Stig Palm, Sture Lindegren, Holger Jensen
Journal of Medical Imaging and Radiation Sciences - 2019 -
Model of Intraperitoneal Targeted α-Particle Therapy Shows That Posttherapy Cold-Antibody Boost Enhances Microtumor Radiation Dose and Treatable Tumor
Sizes.
Stig Palm, Tom Bäck, Sture Lindegren, Ragnar Hultborn, Lars Jacobsson, Per Albertsson
Journal of nuclear medicine : official publication, Society of Nuclear Medicine - 2018 -
Immunohistochemical evaluation of epithelial ovarian carcinomas identifies three different expression patterns of the MX35 antigen,
NaPi2b
Kristina Levan, Martin Mehryar, Constantina Mateoiu, Per Albertsson, Tom Bäck, Karin Sundfeldt
Bmc Cancer - 2017 -
Pharmacokinetics, microscale distribution, and dosimetry of alpha-emitter-labeled anti-PD-L1 antibodies in an immune competent transgenic breast cancer
model
J. R. Nedrow, A. Josefsson, S. Park, Tom Bäck, R. F. Hobbs, C. Brayton, F. Bruchertseifer, A. Morgenstern, G. Sgouros
Ejnmmi Research - 2017 -
Cure of Human Ovarian Carcinoma Solid Xenografts by Fractionated alpha-Radioimmunotherapy with At-211-MX35-F(ab')(2): Influence of Absorbed Tumor Dose and Effect on Long-Term
Survival
Tom Bäck, N. Chouin, Sture Lindegren, Helena Kahu, H. Jensen, Per Albertsson, Stig Palm
Journal of Nuclear Medicine - 2017 -
Therapeutic efficacy of alpha-radioimmunotherapy with different activity levels of the Bi-213-labeled monoclonal antibody MX35 in an ovarian cancer
model
Anna Gustafsson-Lutz, Tom Bäck, Emma Aneheim, Ragnar Hultborn, Stig Palm, Lars Jacobsson, A. Morgenstern, F. Bruchertseifer, Per Albertsson, Sture Lindegren
EJNMMI Research - 2017 -
Biokinetic modeling and dosimetry for optimizing intraperitoneal radioimmunotherapy of ovarian cancer
microtumors.
Stig Palm, Tom Bäck, Börje Haraldsson, Lars Jacobsson, Sture Lindegren, Per Albertsson
Journal of nuclear medicine : official publication, Society of Nuclear Medicine - 2016 -
Synthesis and Evaluation of Astatinated N-[2-(Maleimido)ethyl]-3-(trimethylstannyl)benzamide
Immunoconjugates
Emma Aneheim, Anna Gustafsson, Per Albertsson, Tom Bäck, Holger Jensen, Stig Palm, Sofia Svedhem, Sture Lindegren
Bioconjugate chemistry - 2016 -
MIRD monograph - Radiobiology and dosimetry for radiopharmaceutical therapy with alpha-particle
emitters.
G Sgouros, Stig Palm, Tom Bäck, Barry Allen, A. Bertrand Brill, Darrell R. Fisher, Robert F. Hobbs, Roger W. Howell, Michael R. McDevitt, Ruby F. Meredith, Brian W. Miller, John C. Roeske, Stavroula Sofou, Hong Song, Julien Torgue, Michael R. Zalutsky
2015 -
α-Imaging Confirmed Efficient Targeting of CD45-Positive Cells After 211At-Radioimmunotherapy for Hematopoietic Cell
Transplantation.
Sofia Frost, Brian W Miller, Tom Bäck, Erlinda B Santos, Donald K Hamlin, Sue E Knoblaugh, Shani L Frayo, Aimee L Kenoyer, Rainer Storb, Oliver W Press, D Scott Wilbur, John M Pagel, Brenda M Sandmaier
Journal of nuclear medicine : official publication, Society of Nuclear Medicine - 2015 -
Binding Affinity, Specificity and Comparative Biodistribution of the Parental Murine Monoclonal Antibody MX35 (Anti-NaPi2b) and Its Humanized Version
Rebmab200.
Sture Lindegren, Luciana N S Andrade, Tom Bäck, Camila Maria L Machado, Bruno Brasil Horta, Carlos Buchpiguel, Ana Maria Moro, Oswaldo Keith Okamoto, Lars Jacobsson, Elin Cederkrantz, Kohshin Washiyama, Emma Aneheim, Stig Palm, Holger Jensen, Maria Carolina B Tuma, Roger Chammas, Ragnar Hultborn, Per Albertsson
PloS one - 2015 -
Automated astatination of biomolecules--a stepping stone towards multicenter clinical
trials.
Emma Aneheim, Per Albertsson, Tom Bäck, Holger Jensen, Stig Palm, Sture Lindegren
Scientific reports - 2015 -
Astatine-211 conjugated to an anti-CD20 monoclonal antibody eradicates disseminated B-cell lymphoma in a mouse
model.
Damian J Green, Mazyar Shadman, Jon C Jones, Shani L Frayo, Aimee L Kenoyer, Mark D Hylarides, Donald K Hamlin, D Scott Wilbur, Ethan R Balkan, Yukang Lin, Brian W Miller, Sofia Frost, Ajay K Gopal, Johnnie J Orozco, Theodore A Gooley, Kelly L Laird, Brian G Till, Tom Bäck, Brenda M Sandmaier, John M Pagel, Oliver W Press
Blood - 2015 -
Comparative Efficacy of 177Lu and 90Y for Anti-CD20 Pretargeted Radioimmunotherapy in Murine Lymphoma Xenograft
Models.
Sofia Frost, Shani L Frayo, Brian W Miller, Johnnie J Orozco, Garrett C Booth, Mark D Hylarides, Yukang Lin, Damian J Green, Ajay K Gopal, John M Pagel, Tom Bäck, Darrell R Fisher, Oliver W Press
PloS one - 2015 -
Modelling the biokinetics of intra-peritoneally administered targeted alpha therapy on patients for improved
dosimetry.
Stig Palm, Tom Bäck, Sture Lindegren, Holger Jensen, Per Albertsson, Lars Jacobsson
Journal of Nuclear Medicine - 2014 -
Effective dose of intraperitoneal α-radioimmunotherapy with
211At.
Elin Cederkrantz, Tom Bäck, Lars Jacobsson, Holger Jensen, Sture Lindegren, Stig Palm, Per Albertsson
Journal of Nuclear Medicine - 2014 -
Image-based small-scale 3D-dosimetry in targeted alpha therapy using voxel dose-point kernels and alpha camera imaging of serial tissue
sections.
Tom Bäck, Nicolas Chouin, Sture Lindegren, Holger Jensen, Per Albertsson, Stig Palm
Journal of Nuclear Medicine - 2014 -
Polylysine-based Effector Molecules and Clearing Agents for Pretargeting Systems in Therapy and Imaging – Increasing Avidity and Specific Activity and Providing Many Ways to Optimize In Vivo
Distribution.
Anna Gustafsson-Lutz, Tom Bäck, Per Albertsson, Stig Palm, A Morgenstern, F Bruchertseifer, Sture Lindegren
European Journal of Nuclear Medicine and Molecular Imaging - 2014 -
Intra-tumoral dose distributions after experimental targeted alpha therapy by Alpha-Camera
imaging.
Nicolas Chouin, Stig Palm, Sture Lindegren, Holger Jensen, Per Albertsson, Tom Bäck
European Journal of Nuclear Medicine and Molecular Imaging - 2014 -
Alpha particle induced DNA damage and repair in normal cultured thyrocytes of different proliferation
status.
Madeleine Nordén Lyckesvärd, Ulla Delle, Helena Kahu, Sture Lindegren, Holger Jensen, Tom Bäck, John Swanpalmer, Kerstin Elmroth
Mutation research. Fundamental and molecular mechanisms of mutagenesis - 2014 -
Sequential Radioimmunotherapy with (177)Lu- and (211)At-Labeled Monoclonal Antibody BR96 in a Syngeneic Rat Colon Carcinoma
Model.
Sophie E Eriksson, Erika Elgström, Tom Bäck, Tomas Ohlsson, Holger Jensen, Rune Nilsson, Sture Lindegren, Jan Tennvall
Cancer biotherapy & radiopharmaceuticals - 2014 -
Ex Vivo Activity Quantification in Micrometastases at the Cellular Scale Using the α-Camera
Technique.
Nicolas Chouin, Sture Lindegren, Sofia Frost, Holger Jensen, Per Albertsson, Ragnar Hultborn, Stig Palm, Lars Jacobsson, Tom Bäck
Journal of nuclear medicine : official publication, Society of Nuclear Medicine - 2013 -
Anti-CD45 radioimmunotherapy using 211At with bone marrow transplantation prolongs survival in a disseminated murine leukemia
model.
Johnnie J Orozco, Tom Bäck, Aimee Kenoyer, Ethan R Balkin, Donald K Hamlin, D Scott Wilbur, Darrell R Fisher, Shani L Frayo, Mark D Hylarides, Damian J Green, Ajay K Gopal, Oliver W Press, John M Pagel
Blood - 2013 -
Comparison of (211)At-PRIT and (211)At-RIT of Ovarian Microtumors in a Nude Mouse
Model.
Sofia Frost, Tom Bäck, Nicolas Chouin, Ragnar Hultborn, Lars Jacobsson, Jörgen Elgqvist, Holger Jensen, Per Albertsson, Sture Lindegren
Cancer biotherapy & radiopharmaceuticals - 2013 -
Successful radioimmunotherapy of established syngeneic rat colon carcinoma with
211At-mAb.
Sophie E Eriksson, Tom Bäck, Erika Elgström, Holger Jensen, Rune Nilsson, Sture Lindegren, Jan Tennvall
EJNMMI research - 2013 -
Tumor Growth of Subcutaneous Xenografts after Repeated Alpha-Radioimmunotherapy with Astatine-211: What Absorbed Dose is Required to Treat Solid Tumors with Alpha-particle
Emitters?
Tom Bäck, Nicolas Chouin, Sture Lindegren, Holger Jensen, Stig Palm, Per Albertsson
European Journal of Nuclear Medicine and Molecular Imaging - 2012 -
Quantification of activity by alpha-camera imaging and small-scale dosimetry within ovarian carcinoma micrometastases treated with targeted alpha
therapy.
Nicolas Chouin, Sture Lindegren, Holger Jensen, Per Albertsson, Tom Bäck
Quarterly Journal of Nuclear Medicine and Molecular Imaging - 2012 -
Comparison of therapeutic efficacy and biodistribution of (213)Bi- and (211)At-labeled monoclonal antibody MX35 in an ovarian cancer
model.
Anna Gustafsson, Tom Bäck, Jörgen Elgqvist, Lars Jacobsson, Ragnar Hultborn, Per Albertsson, Alfred Morgenstern, Frank Bruchertseifer, Holger Jensen, Sture Lindegren
Nuclear medicine and biology - 2012
More publications
We have limited the number of publications on this page. Visit GUP (The Publication Database for Gothenburg University) to find more publications.