Per Larsson
About Per Larsson
I have an MSc in chemistry with emphasis towards analytical chemistry and biochemistry. After finishing my MSc in 2006 I was employed as chemist by Sahlgrenska Universitetssjukhuset for a few years before I was given the opportunity to become a full time PhD student at the Department of Public Health and Community Medicine in 2010. The focus of our research group is biomarkers and airway inflammation. Chronic airway inflammation is associated to many common airway diseases such as asthma and COPD yet there is no widely applicable method for early detection and monitoring of small airway inflammation at present. To address this, we have developed a new method to obtain samples of the respiratory tract lining fluid that covers the small airways. The method is based on sampling of small airborne droplets that are formed from the fluid in the small airways, and in particular during a certain breathing maneuver. The droplets are small enough to be carried in the exhaled air from the small airways to the mouth where they can be sampled conveniently. We have developed an instrument with the purpose of quantifying the amount of exhaled droplets while at the same time collecting them for chemical analysis. Because the droplets are formed in the small airways they are considered to have a chemical composition that is representative of the respiratory lining fluid in small airways and are likely to contain biomarkers that reflects the inflammatory condition. My research focus is on both sampling and analyzing the exhaled droplets. Currently we have a few analytical methods that have been validated and are being used in clinical studies with promising results. A particularly interesting project that I am now working on is to analyze surfactant protein A by SRM/MRM mass spectrometry. The purpose is to cross validate the immunological method that we are using today and also to study how structural variations can influence the immunological functions of the protein.
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Severe acute respiratory syndrome coronavirus 2 can be detected in exhaled aerosol sampled during a few minutes of breathing or
coughing
Emilia Viklund, Spela Kokelj, Per Larsson, Rickard Nordén, Maria Andersson, Olof Beck, Johan Westin, Anna-Carin Olin
Influenza and other Respiratory Viruses - 2022 -
Current smoking alters phospholipid- and surfactant protein A levels in small airway lining fluid: An explorative study on exhaled
breath
Emilia Viklund, Björn Bake, Laith Hussain-Alkhateeb, Hatice Koca Akdeva, Per Larsson, Anna-Carin Olin
Plos One - 2021 -
Small droplet emission in exhaled breath during different breathing manoeuvres: Implications for clinical lung function testing during
COVID-19
Neil J. Greening, Per Larsson, Evert Ljungström, Salman Siddiqui, Anna-Carin Olin
Allergy: European Journal of Allergy and Clinical Immunology - 2021 -
Two techniques to sample non-volatiles in breath-exemplified by
methadone.
Göran Ljungkvist, Shahid Ullah, Åsa Tinglev, Karina Stein, Björn Bake, Per Larsson, Ann-Charlotte Almstrand, Emilia Viklund, Oscar Hammar, Sören Sandqvist, Olof Beck, Anna-Carin Olin
Journal of breath research - 2018 -
The effect of exhalation flow on endogenous particle emission and phospholipid
composition
Per Larsson, Björn Bake, Anita Wallin, O. Hammar, Ann-Charlotte Almstrand, Mona Lärstad, Evert Ljungström, Ekaterina Mirgorodskaya, Anna-Carin Olin
Respiratory Physiology & Neurobiology - 2017 -
Exhaled particles as markers of small airway inflammation in subjects with
asthma
Per Larsson, Mona Lärstad, Björn Bake, Oscar Hammar, Anna Bredberg, Ann-Charlotte Almstrand, Ekaterina Mirgorodskaya, Anna-Carin Olin
Clinical Physiology and Functional Imaging - 2017 -
Low Levels of Exhaled Surfactant Protein A Associated With BOS After Lung
Transplantation
Petrea Ericson, Ekaterina Mirgorodskaya, Oscar Hammar, Emilia Viklund, Ann-Charlotte Almstrand, Per Larsson, Gerdt C. Riise, Anna-Carin Olin
Transplantation Direct - 2016 -
Surfactant Protein A in Exhaled Endogenous Particles Is Decreased in Chronic Obstructive Pulmonary Disease (COPD) Patients: A Pilot
Study
Mona Lärstad, Ann-Charlotte Almstrand, Per Larsson, Björn Bake, Sven Larsson, Evert Ljungström, Ekaterina Mirgorodskaya, Anna-Carin Olin
Plos One - 2015 -
Biomarker for welding exposure in exhaled endogenous
particles
Göran Ljungqvist, Anna Bredberg, Fabian Taube, Evert Ljungström, Per Larsson, Ekaterina Mirogorodskaya, Christina Isaxon, Niklas Forsgard, Jakob Löndahl, Anna-Carin Olin
The European respiratory journal. Supplement - 2014 -
Analysis of manganese and iron in exhaled endogenous
particles
Anna Bredberg, Göran Ljungqvist, Fabian Taube, Evert Ljungström, Per Larsson, Ekaterina Mirgorodskaya, Christina Isaxon, Anders Gudmundsson, Niklas Forsgård, Anna-Carin Olin
Journal of Analytical Atomic Spectrometry - 2014 -
Analyses of Cadmium in particles in Exhaled Air (PEx) in smokers and
non-smokers
Fabian Taube, Anna Bredberg, Per Larsson, Magdalena Taube, Anna-Carin Olin
Svenska Läkarstämman - 2013 -
Comparison of Exhaled Endogenous Particles from Smokers and Non-Smokers Using Multivariate
Analysis
Anna Bredberg, M. Josefson, Ann-Charlotte Almstrand, J. Lausmaa, P. Sjovall, Anna Levinsson, Per Larsson, Anna-Carin Olin
Respiration - 2013 -
Effects of breath holding at low and high lung volumes on amount of exhaled
particles
Helene Holmgren, Emilie Gerth, Evert Ljungström, Per Larsson, Ann-Charlotte Almstrand, Björn Bake, Anna-Carin Olin
Respiratory Physiology & Neurobiology - 2013 -
Pneumoproteins in sewage workers exposed to sewage
dust
Kari Kulvik Heldal, Lars Barregård, Per Larsson, Dag G. Ellingsen
International Archives of Occupational and Environmental Health - 2013 -
Exhaled Endogenous Particles Contain Lung
Proteins.
Anna Bredberg, Johan Gobom, Ann-Charlotte Almstrand, Per Larsson, Kaj Blennow, Anna-Carin Olin, Ekaterina Mirgorodskaya
Clinical Chemistry - 2012 -
TOF-SIMS analysis of exhaled particles from patients with asthma and healthy
controls.
Ann-Charlotte Almstrand, M Josefson, Anna Bredberg, Jukka Lausmaa, Peter Sjövall, Per Larsson, Anna-Carin Olin
The European respiratory journal: official journal of the European Society for Clinical Respiratory Physiology - 2012 -
Surfactant protein A and albumin in particles in exhaled
air.
Per Larsson, Ekaterina Mirgorodskaya, Lena Samuelsson, Björn Bake, Ann-Charlotte Almstrand, Anna Bredberg, Anna-Carin Olin
Respiratory medicine - 2012 -
Effect of Airway Opening on Production of Exhaled
Particles.
Ann-Charlotte Almstrand, Björn Bake, Evert Ljungström, Per Larsson, Anna Bredberg, Ekaterina Mirgorodskaya, Anna-Carin Olin
Journal of applied physiology - 2010