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Johan Gobom
Researcher
Department of Psychiatry and Neurochemistry-
CSF proteomic profiles of neurodegeneration biomarkers in Alzheimer's
disease
Aurore Delvenne, Johan Gobom, Suzanne E. Schindler, Mara ten Kate, Lianne M. Reus, Valerija Dobricic, Betty M. Tijms, Tammie L. S. Benzinger, Carlos Cruchaga, Charlotte E. Teunissen, Inez Ramakers, Pablo Martinez-Lage, Mikel Tainta, Rik Vandenberghe, Jolien Schaeverbeke, Sebastiaan Engelborghs, Ellen De Roeck, Julius Popp, Gwendoline Peyratout, Magda Tsolaki, Yvonne Freund-Levi, Simon Lovestone, Johannes Streffer, Frederik Barkhof, Lars Bertram, Kaj Blennow, Henrik Zetterberg, Pieter Jelle Visser, Stephanie J. B. Vos
ALZHEIMERS & DEMENTIA - 2024 -
Alzheimer's Disease Biomarker Analysis Using Targeted Mass
Spectrometry.
Johan Gobom, Ann Brinkmalm-Westman, Gunnar Brinkmalm, Kaj Blennow, Henrik Zetterberg
Molecular & cellular proteomics : MCP - 2024 -
Tau protein profiling in tauopathies: a human brain
study
Juan Lantero Rodriguez, Elena Camporesi, Laia Montoliu-Gaya, Johan Gobom, Diana Piotrowska, Maria Olsson, Irena Matečko-Burmann, Bruno Becker, Ann Brinkmalm, Björn Marcus Burmann, Michael Perkinton, Nicholas J. Ashton, Nick C. Fox, Tammaryn Lashley, Henrik Zetterberg, Kaj Blennow, Gunnar Brinkmalm
MOLECULAR NEURODEGENERATION - 2024 -
Post-GWAS multiomic functional investigation of the <i>TNIP1</i> locus in Alzheimer's disease highlights a potential role for
GPX3
Daniel J. Panyard, Lianne M. Reus, Muhammad Ali, Jihua Liu, Yuetiva K. Deming, Qiongshi Lu, Gwendlyn Kollmorgen, Margherita Carboni, Norbert Wild, Pieter J. Visser, Lars Bertram, Henrik Zetterberg, Kaj Blennow, Johan Gobom, Dan Western, Yun Ju Sung, Cynthia M. Carlsson, Sterling C. Johnson, Sanjay Asthana, Carlos Cruchaga, Betty M. Tijms, Corinne D. Engelman, Michael P. Snyder
ALZHEIMERS & DEMENTIA - 2024 -
Pathophysiological subtypes of mild cognitive impairment due to Alzheimer's disease identified by CSF
proteomics.
Daniela Moutinho, Vera M Mendes, Alessandro Caula, Sara C Madeira, Inês Baldeiras, Manuela Guerreiro, Sandra Cardoso, Johan Gobom, Henrik Zetterberg, Isabel Santana, Alexandre De Mendonça, Helena Aidos, Bruno Manadas
Translational neurodegeneration - 2024 -
Profiling amyloid-β peptides as biomarkers for cerebral amyloid
angiopathy
Emma van den Berg, Iris Kersten, Gunnar Brinkmalm, Kjell Johansson, Anna M. de Kort, Catharina J. M. Klijn, Floris H. B. M. Schreuder, Johan Gobom, Erik Stoops, Erik Portelius, Eleni Gkanatsiou, Henrik Zetterberg, Kaj Blennow, Hinke B. Kuiperij, Marcel M. Verbeek
JOURNAL OF NEUROCHEMISTRY - 2024 -
Cerebrospinal fluid biomarker panel for synaptic dysfunction in a broad spectrum of neurodegenerative
diseases.
Johanna Nilsson, Alexa Pichet Binette, Sebastian Palmqvist, Wagner Scheeren Brum, Shorena Janelidze, Nicholas J. Ashton, Nicola Spotorno, Erik Stomrud, Johan Gobom, Henrik Zetterberg, Ann Brinkmalm, Kaj Blennow, Oskar Hansson
Brain : a journal of neurology - 2024 -
Optimal blood tau species for the detection of Alzheimer's disease neuropathology: an immunoprecipitation mass spectrometry and autopsy
study.
Laia Montoliu-Gaya, Michael L Alosco, Eukyung Yhang, Yorghos Tripodis, Daniel Sconzo, Madeline Ally, Lana Grötschel, Nicholas J. Ashton, Juan Lantero Rodriguez, Mathias Sauer, Bárbara Fernandes Gomes, Johanna Nilsson, Gunnar Brinkmalm, Michael A Sugarman, Hugo J Aparicio, Brett Martin, Joseph N Palmisano, Eric G Steinberg, Irene Simkin, Katherine W Turk, Andrew E Budson, Rhoda Au, Lindsay Farrer, Gyungah R Jun, Neil W Kowall, Robert A Stern, Lee E Goldstein, Wei Qiao Qiu, Jesse Mez, Bertrand Russell Huber, Victor E Alvarez, Ann C McKee, Henrik Zetterberg, Johan Gobom, Thor D Stein, Kaj Blennow
Acta neuropathologica - 2024 -
Differential patterns of lysosomal dysfunction are seen in the clinicopathological forms of primary progressive
aphasia
I. J. Swift, Simon Sjödin, Johan Gobom, Ann Brinkmalm, Kaj Blennow, Henrik Zetterberg, J. D. Rohrer, A. Sogorb-Esteve
Journal of Neurology - 2024 -
Comparison of immunoassay- with mass spectrometry-derived p-tau quantification for the detection of Alzheimer’s disease
pathology
Joseph Therriault, Marcel S. Woo, Gemma Salvadó, Johan Gobom, Thomas Karikari, Shorena Janelidze, Stijn Servaes, Nesrine Rahmouni, Cécile Tissot, Nicholas J. Ashton, Andréa Lessa Benedet, Laia Montoliu-Gaya, Arthur C. Macedo, Firoza Z. Lussier, Jenna Stevenson, Paolo Vitali, Manuel A. Friese, Gassan Massarweh, Jean Paul Soucy, Tharick A. Pascoal, Erik Stomrud, Sebastian Palmqvist, Niklas Mattsson-Carlgren, Serge Gauthier, Henrik Zetterberg, Oskar Hansson, Kaj Blennow, Pedro Rosa-Neto
Molecular Neurodegeneration - 2024 -
SCRN1: A cerebrospinal fluid biomarker correlating with tau in Alzheimer's
disease
Sophia Weiner, Mathias Sauer, Gunnar Brinkmalm, Julius Constantinescu, Radu Constantinescu, Bárbara Fernandes Gomes, Bruno Becker, Bengt Nellgård, Keti Dalla, Douglas Galasko, Henrik Zetterberg, Kaj Blennow, Johan Gobom
Alzheimer's and Dementia - 2023 -
α-Synuclein seed amplification assay as a diagnostic tool for parkinsonian
disorders.
Bárbara Fernandes Gomes, Carly M Farris, Yihua Ma, Luis Concha-Marambio, Russ Lebovitz, Bengt Nellgård, Keti Dalla, Julius Constantinescu, Radu Constantinescu, Johan Gobom, Ulf Andreasson, Henrik Zetterberg, Kaj Blennow
Parkinsonism & related disorders - 2023 -
Cerebrospinal Fluid Panel of Synaptic Proteins in Cerebral Amyloid Angiopathy and Alzheimer's
Disease
E. van den Berg, Johanna Nilsson, I. Kersten, Gunnar Brinkmalm, A. M. de Kort, C. J. M. Klijn, Fhbm Schreuder, L. Jakel, Johan Gobom, E. Portelius, Henrik Zetterberg, Ann Brinkmalm, Kaj Blennow, H. B. Kuiperij, M. M. Verbeek
Journal of Alzheimers Disease - 2023 -
Cerebrospinal fluid proteomic profiling of individuals with mild cognitive impairment and suspected non-Alzheimer's disease
pathophysiology
A. Delvenne, Johan Gobom, B. Tijms, I. Bos, L. M. Reus, V. Dobricic, M. Ten Kate, F. Verhey, I. Ramakers, P. Scheltens, C. E. Teunissen, R. Vandenberghe, J. Schaeverbeke, S. Gabel, J. Popp, G. Peyratout, P. Martinez-Lage, M. Tainta, M. Tsolaki, Y. Freund-Levi, S. Lovestone, J. Streffer, F. Barkhof, L. Bertram, Kaj Blennow, Henrik Zetterberg, P. J. Visser, S. J. B. Vos
Alzheimers & Dementia - 2023 -
Assessing the commutability of candidate reference materials for the harmonization of neurofilament light measurements in
blood
Ulf Andreasson, Johan Gobom, V. Delatour, G. Auclair, Y. Noam, S. P. Lee, J. S. Wen, A. Jeromin, Burak Arslan, A. Maceski, E. Willemse, Henrik Zetterberg, J. Kuhle, Kaj Blennow
Clinical Chemistry and Laboratory Medicine - 2023 -
Next-generation proteomics technologies in Alzheimer's disease: from clinical research to routine
diagnostics
Sophia Weiner, Kaj Blennow, Henrik Zetterberg, Johan Gobom
Expert Review of Proteomics - 2023 -
Harmonization and standardization of biofluid-based biomarker measurements for AT(N) classification in Alzheimer's
disease
C. Giangrande, V. Delatour, Ulf Andreasson, Kaj Blennow, Johan Gobom, Henrik Zetterberg
Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring - 2023 -
Mass spectrometric simultaneous quantification of tau species in plasma shows differential associations with amyloid and tau
pathologies
Laia Montoliu-Gaya, Andréa Lessa Benedet, C. Tissot, A. Vrillon, Nicholas J. Ashton, Wagner Scheeren Brum, Juan Lantero Rodriguez, J. Stevenson, Johanna Nilsson, Mathias Sauer, N. Rahmouni, Gunnar Brinkmalm, F. Z. Lussier, T. A. Pascoal, Ingmar Skoog, Silke Kern, Henrik Zetterberg, C. Paquet, Johan Gobom, P. Rosa-Neto, Kaj Blennow
Nature Aging - 2023 -
Protein disulfide isomerases as CSF biomarkers for the neuronal response to tau
pathology
K. Wolzak, L. Vermunt, M. del Campo, M. Jorge-Oliva, A. M. van Ziel, K. W. Li, A. B. Smit, A. Chen-Ploktkin, D. J. Irwin, A. W. Lemstra, Y. Pijnenburg, W. van der Flier, Henrik Zetterberg, Johan Gobom, Kaj Blennow, P. J. Visser, C. E. Teunissen, B. M. Tijms, W. Scheper
Alzheimers & Dementia - 2023 -
Cerebrospinal fluid biomarker panel of synaptic dysfunction in Alzheimer's disease and other neurodegenerative
disorders
Johanna Nilsson, K. A. Q. Cousins, Johan Gobom, E. Portelius, A. Chen-Plotkin, L. M. Shaw, M. Grossman, D. J. Irwin, J. Q. Trojanowski, Henrik Zetterberg, Kaj Blennow, Ann Brinkmalm
Alzheimers & Dementia - 2023 -
Novel cerebrospinal fluid biomarkers correlating with shunt responsiveness in patients with idiopathic normal pressure
hydrocephalus
Sophia Weiner, A. Junkkari, M. Sauer, A. Luikku, T. Rauramaa, T. Kokkola, S. K. Herukka, Kaj Blennow, Henrik Zetterberg, V. Leinonen, Johan Gobom
Fluids and Barriers of the Cns - 2023 -
Differential impairment of cerebrospinal fluid synaptic biomarkers in the genetic forms of frontotemporal
dementia.
Aitana Sogorb-Esteve, Johanna Nilsson, Imogen J Swift, Carolin Heller, Martina Bocchetta, Lucy L Russell, Georgia Peakman, Rhian S Convery, John C van Swieten, Harro Seelaar, Barbara Borroni, Daniela Galimberti, Raquel Sanchez-Valle, Robert Laforce, Fermin Moreno, Matthis Synofzik, Caroline Graff, Mario Masellis, Maria Carmela Tartaglia, James B Rowe, Rik Vandenberghe, Elizabeth Finger, Fabrizio Tagliavini, Isabel Santana, Chris R Butler, Simon Ducharme, Alexander Gerhard, Adrian Danek, Johannes Levin, Markus Otto, Sandro Sorbi, Isabelle Le Ber, Florence Pasquier, Johan Gobom, Ann Brinkmalm-Westman, Kaj Blennow, Henrik Zetterberg, Jonathan D Rohrer
Alzheimer's research & therapy - 2022 -
Effects of age, amyloid, sex, and APOE epsilon 4 on the CSF proteome in normal
cognition
K. E. J. Wesenhagen, Johan Gobom, I. Bos, S. J. B. Vos, P. Martinez-Lage, J. Popp, M. Tsolaki, R. Vandenberghe, Y. Freund-Levi, F. Verhey, S. Lovestone, J. Streffer, V. Dobricic, L. Bertram, Kaj Blennow, M. Pikkarainen, M. Hallikainen, J. Kuusisto, M. Laakso, H. Soininen, P. Scheltens, Henrik Zetterberg, C. E. Teunissen, P. J. Visser, B. M. Tijms
Alzheimer's & Dementia - 2022 -
Quantification of SNAP-25 with mass spectrometry and Simoa: a method comparison in Alzheimer's
disease
Johanna Nilsson, Nicholas J. Ashton, Andréa Lessa Benedet, Laia Montoliu-Gaya, Johan Gobom, T. A. Pascoal, M. Chamoun, E. Portelius, A. Jeromin, M. Mendes, Henrik Zetterberg, P. Rosa-Neto, Ann Brinkmalm, Kaj Blennow
Alzheimer's Research & Therapy - 2022 -
Optimized sample preparation and data analysis for TMT proteomic analysis of cerebrospinal fluid applied to the identification of Alzheimer's disease
biomarkers
Sophia Weiner, M. Sauer, P. J. Visser, B. M. Tijms, Egor Vorontsov, Kaj Blennow, Henrik Zetterberg, Johan Gobom
Clinical Proteomics - 2022 -
Validation of the LUMIPULSE automated immunoassay for the measurement of core AD biomarkers in cerebrospinal
fluid.
Johan Gobom, Lucilla Parnetti, Pedro Rosa-Neto, Martin Vyhnalek, Serge Gauthier, Samuela Cataldi, Ondrej Lerch, Jan Laczo, Katerina Cechova, Marcus Clarin, Andrea I Benet, Tharick A Pascoal, Neserine Rahmouni, Manu Vandijck, Else Huyck, Nathalie Le Bastard, Jenna Stevenson, Mira Chamoun, Daniel Alcolea, Alberto Lleó, Ulf Andreasson, Marcel M Verbeek, Giovanni Bellomo, Roberta Rinaldi, Nicholas J. Ashton, Henrik Zetterberg, Katerina Sheardova, Jakub Hort, Kaj Blennow
Clinical chemistry and laboratory medicine - 2022 -
Cerebrospinal Fluid Biomarkers of Synaptic Dysfunction Are Altered in Parkinson's Disease and Related
Disorders.
Johanna Nilsson, Julius Constantinescu, Bengt Nellgård, Protik Jakobsson, Wagner Scheeren Brum, Johan Gobom, Lars Forsgren, Keti Dalla, Radu Constantinescu, Henrik Zetterberg, Oskar Hansson, Kaj Blennow, David Bäckström, Ann Brinkmalm-Westman
Movement disorders : official journal of the Movement Disorder Society - 2022 -
Antibody-free measurement of cerebrospinal fluid tau phosphorylation across the Alzheimer's disease
continuum.
Johan Gobom, Andréa Lessa Benedet, Niklas Mattsson-Carlgren, Laia Montoliu-Gaya, Nina Schultz, Nicholas J. Ashton, Shorena Janelidze, Stijn Servaes, Mathias Sauer, Tharick A Pascoal, Thomas Karikari, Juan Lantero Rodriguez, Gunnar Brinkmalm, Henrik Zetterberg, Oskar Hansson, Pedro Rosa-Neto, Kaj Blennow
Molecular neurodegeneration - 2022 -
Establishment of reference values for plasma neurofilament light based on healthy individuals aged 5-90
years
Joel Simrén, Ulf Andreasson, Johan Gobom, M. S. Calvet, B. Borroni, Christopher Gillberg, L. Nyberg, R. Ghidoni, Elisabeth Fernell, Mats Johnson, H. Depypere, Caroline Hansson, Ingibjörg H Jonsdottir, Henrik Zetterberg, Kaj Blennow
Brain Communications - 2022 -
Increased CSF-decorin predicts brain pathological changes driven by Alzheimer's A beta
amyloidosis
R. C. Jiang, U. Smailovic, H. Haytural, B. M. Tijms, H. Li, R. M. Haret, G. Shevchenko, G. F. Chen, A. Abelein, Johan Gobom, S. Frykman, M. Sekiguchi, R. Fujioka, N. Watamura, H. Sasaguri, S. Nystrom, P. Hammarstrom, T. C. Saido, V. Jelic, S. Syvanen, Henrik Zetterberg, B. Winblad, J. Bergquist, P. J. Visser, P. Nilsson
Acta Neuropathologica Communications - 2022 -
Cerebrospinal fluid tau levels are associated with abnormal neuronal plasticity markers in Alzheimer's
disease
P. J. Visser, L. M. Reus, Johan Gobom, I. Jansen, E. Dicks, S. J. Van der Lee, M. Tsolaki, F. R. J. Verhey, J. Popp, P. Martinez-Lage, R. Vandenberghe, A. Lleo, J. L. Molinuevo, S. Engelborghs, Y. Freund-Levi, L. Froelich, K. Sleegers, V. Dobricic, S. Lovestone, J. Streffer, S. J. B. Vos, I. Bos, A. B. Smit, Kaj Blennow, P. Scheltens, C. E. Teunissen, L. Bertram, Henrik Zetterberg, B. M. Tijms, Adni, Adni,
Molecular Neurodegeneration - 2022 -
Correction: Cerebrospinal fluid tau levels are associated with abnormal neuronal plasticity markers in Alzheimer's
disease.
Pieter Jelle Visser, Lianne M Reus, Johan Gobom, Iris Jansen, Ellen Dicks, Sven J van der Lee, Magda Tsolaki, Frans R J Verhey, Julius Popp, Pablo Martinez-Lage, Rik Vandenberghe, Alberto Lleó, José Luís Molinuevo, Sebastiaan Engelborghs, Yvonne Freund-Levi, Lutz Froelich, Kristel Sleegers, Valerija Dobricic, Simon Lovestone, Johannes Streffer, Stephanie J B Vos, Isabelle Bos, August B Smit, Kaj Blennow, Philip Scheltens, Charlotte E Teunissen, Lars Bertram, Henrik Zetterberg, Betty M Tijms
Molecular neurodegeneration - 2022 -
Corrigendum to "Use of the tau protein-to-peptide ratio in CSF to improve diagnostic classification of Alzheimer's disease" [Clin. Mass Spectrom. 14 (Part B) (2019)
74-82].
Karl Hansson, Rahil Dahlén, Oskar Hansson, Elin Pernevik, Ross Paterson, Jonathan M Schott, Nadia Magdalinou, Henrik Zetterberg, Kaj Blennow, Johan Gobom
Journal of mass spectrometry and advances in the clinical lab - 2022 -
Genome-scale metabolic network reconstruction of model animals as a platform for translational
research
Hao Wang, J. L. Robinson, P. Kocabas, J. Gustafsson, M. Anton, P. E. Cholley, S. Huang, Johan Gobom, T. Svensson, M. Uhlen, Henrik Zetterberg, J. Nielsen
Proceedings of the National Academy of Sciences of the United States of America - 2021 -
Differential Stimulation of Pluripotent Stem Cell-Derived Human Microglia Leads to Exosomal Proteomic Changes Affecting
Neurons
A. Mallach, Johan Gobom, C. Arber, T. M. Piers, J. Hardy, S. Wray, Henrik Zetterberg, J. Pocock
Cells - 2021 -
The influence of the R47H triggering receptor expressed on myeloid cells 2 variant on microglial exosome
profiles
A. Mallach, Johan Gobom, Henrik Zetterberg, J. Hardy, T. M. Piers, S. Wray, J. M. Pocock
Brain Communications - 2021 -
Transitioning from cerebrospinal fluid to blood tests to facilitate diagnosis and disease monitoring in Alzheimer's
disease.
Deborah O T Alawode, Amanda J Heslegrave, Nicholas J. Ashton, Thomas Karikari, Joel Simrén, Laia Montoliu-Gaya, Josef Pannee, Antoinette O Connor, Philip S J Weston, Juan Lantero Rodriguez, Ashvini Keshavan, Anniina Snellman, Johan Gobom, Ross W Paterson, Jonathan M Schott, Kaj Blennow, Nick C Fox, Henrik Zetterberg
Journal of internal medicine - 2021 -
CSF Proteomic Alzheimer's Disease-Predictive Subtypes in Cognitively Intact Amyloid Negative
Individuals
B. M. Tijms, Johan Gobom, C. Teunissen, V. Dobricic, M. Tsolaki, F. Verhey, J. Popp, P. Martinez-Lage, R. Vandenberghe, A. Lleo, J. L. Molinuevo, S. Engelborghs, Y. Freund-Levi, L. Froelich, L. Bertram, S. Lovestone, J. Streffer, S. Vos, Kaj Blennow, P. Scheltens, H. Zetterberg, P. J. Visser, Adni, Adni,
Proteomes - 2021 -
Neuroligin-1 in brain and CSF of neurodegenerative disorders: investigation for synaptic
biomarkers
Elena Camporesi, T. Lashley, Johan Gobom, Juan Lantero Rodriguez, O. Hansson, Henrik Zetterberg, Kaj Blennow, Bruno Becker
Acta Neuropathologica Communications - 2021 -
Cerebrospinal fluid biomarker panel for synaptic dysfunction in Alzheimer's
disease
Johanna Nilsson, Johan Gobom, Simon Sjödin, Gunnar Brinkmalm, Nicholas J. Ashton, Johan Svensson, Per Johansson, E. Portelius, Henrik Zetterberg, Kaj Blennow, Ann Brinkmalm
Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring - 2021 -
Alzheimer's disease genetic risk variants show brain cell type-specific associations with protein levels in cerebrospinal
fluid
L. M. Reus, S. J. Van Der Lee, C. E. Teunissen, Johan Gobom, S. J. B. Vos, Kaj Blennow, Henrik Zetterberg, L. Bertram, P. J. Visser, B. M. Tijms
Alzheimer's & dementia : the journal of the Alzheimer's Association - 2021 -
A mass spectrometric approach to study the interaction of amyloid beta peptides with human
alpha-2-macroglobulin
A. V. Protasov, O. A. Mirgorodskaya, Y. P. Kozmin, Johan Gobom
Biochimie - 2021 -
Sample Preparation for Proteomic Analysis of Cerebrospinal
Fluid
Johan Gobom
Cerebrospinal Fluid Biomarkers. Teunissen C.E., Zetterberg H. (red.) - 2021 -
APOE ϵ4 genotype-dependent cerebrospinal fluid proteomic signatures in Alzheimer's
disease
E. Konijnenberg, B. M. Tijms, Johan Gobom, V. Dobricic, I. Bos, S. Vos, M. Tsolaki, F. Verhey, J. Popp, P. Martinez-Lage, R. Vandenberghe, A. Lleó, L. Frölich, S. Lovestone, J. Streffer, L. Bertram, Kaj Blennow, C. E. Teunissen, R. Veerhuis, A. B. Smit, P. Scheltens, Henrik Zetterberg, P. J. Visser
Alzheimer's Research and Therapy - 2020 -
Author reply to the Letter to the Editor by Prof.Dr. Dr Mischak: "Re-analysis of peptidomic analysis of cartilage and subchondral bone in OA
patients".
Birgitta Gatenholm, Johan Gobom, Henrik Zetterberg, Mats Brittberg
European journal of clinical investigation - 2020 -
Protein aggregate formation permits millennium-old brain
preservation
A. Petzold, C. H. Lu, M. Groves, Johan Gobom, Henrik Zetterberg, G. Shaw, S. O'Connor
Journal of the Royal Society Interface - 2020 -
Pathophysiological subtypes of Alzheimer's disease based on cerebrospinal fluid
proteomics
B. M. Tijms, Johan Gobom, L. Reus, I. Jansen, S. J. Hong, V. Dobricic, F. Kilpert, M. ten Kate, F. Barkhof, M. Tsolaki, F. R. J. Verhey, J. Popp, P. Martinez-Lage, R. Vandenberghe, A. Lle, J. L. Molinuevo, S. Engelborghs, L. Bertram, S. Lovestone, J. Streffer, S. Vos, I. Bos, Kaj Blennow, P. Scheltens, C. E. Teunissen, Henrik Zetterberg, P. J. Visser
Brain - 2020 -
Cerebrospinal fluid total tau levels indicate aberrant neuronal plasticity in Alzheimer's
disease.
Pieter Jelle Visser, Lianne M Reus, Johan Gobom, Iris Jansen, Ellen Dicks, Magda Tsolaki, Frans R J Verhey, Julius Popp, Pablo Martinez-Lage, Rik Vandenberghe, Alberto Lleó, José Luís Molinuevo, Sebastiaan Engelborghs, Yvonne Freund-Levi, Lutz Froelich, Kristel Sleegers, Valerija Dobricic, Shengjun Hong, Simon Lovestone, Johannes Streffer, Stephanie J B Vos, Isabelle Bos, August B Smit, Kaj Blennow, Philip Scheltens, Charlotte E Teunissen, Lars Bertram, Henrik Zetterberg, Betty M Tijms
medRxiv : the preprint server for health sciences - 2020 -
First amyloid β1-42 certified reference material for re-calibrating commercial
immunoassays
S. Boulo, J. Kuhlmann, Ulf Andreasson, B. Brix, I. Venkataraman, V. Herbst, S. Rutz, E. Manuilova, M. Vandijck, F. Dekeyser, Maria Bjerke, Josef Pannee, J. Charoud-Got, G. Auclair, S. Mazoua, G. Pinski, S. Trapmann, H. Schimmel, H. Emons, M. Quaglia, Erik Portelius, M. Korecka, L. M. Shaw, M. Lame, E. Chambers, H. Vanderstichele, E. Stoops, A. Leinenbach, T. Bittner, R. G. Jenkins, V. Kostanjevecki, P. Lewczuk, Johan Gobom, Henrik Zetterberg, I. Zegers, Kaj Blennow
Alzheimer's and Dementia - 2020 -
Peptidomic analysis of cartilage and subchondral bone in OA
patients
Birgitta Gatenholm, Johan Gobom, Tobias Skillbäck, Kaj Blennow, Henrik Zetterberg, Mats Brittberg
European Journal of Clinical Investigation - 2019 -
Novel tau fragments in cerebrospinal fluid: relation to tangle pathology and cognitive decline in Alzheimer's
disease.
Claudia Cicognola, Gunnar Brinkmalm, Johan Gobom, Jessica Wahlgren, Nicholas C Cullen, Lucilla Parnetti, Radu Constantinescu, Kristin Wildsmith, Hsu-Hsin Chen, Thomas G Beach, Tammaryn Lashley, Henrik Zetterberg, Kaj Blennow, Kina Höglund
Acta neuropathologica - 2019 -
Use of the tau protein-to-peptide ratio in CSF to improve diagnostic classification of Alzheimer's
disease
Karl Hansson, Rahil Dahlén, O. Hansson, Elin Pernevik, R. Paterson, J. M. Schott, N. Magdalinou, Henrik Zetterberg, Kaj Blennow, Johan Gobom
Clinical Mass Spectrometry - 2019 -
Fluid-based proteomics targeted on pathophysiological processes and pathologies in neurodegenerative
diseases.
Ann Brinkmalm-Westman, Erik Portelius, Gunnar Brinkmalm, Josef Pannee, Rahil Dahlén, Johan Gobom, Kaj Blennow, Henrik Zetterberg
Journal of neurochemistry - 2019 -
Levels of ADAM10 are reduced in Alzheimer's disease
CSF
A. Sogorb-Esteve, M. S. Garcia-Ayllon, Johan Gobom, J. Alom, Henrik Zetterberg, Kaj Blennow, J. Saez-Valero
Journal of Neuroinflammation - 2018 -
Sample Preparation for Endopeptidomic Analysis in Human Cerebrospinal
Fluid
Karl Hansson, Tobias Skillbäck, Elin Pernevik, Jessica Holmén Larsson, Gunnar Brinkmalm, Kaj Blennow, Henrik Zetterberg, Johan Gobom
Jove-Journal of Visualized Experiments - 2017 -
A novel quantification-driven proteomic strategy identifies an endogenous peptide of pleiotrophin as a new biomarker of Alzheimer's
disease
Tobias Skillbäck, Niklas Mattsson, Karl Hansson, Ekaterina Mirgorodskaya, Rahil Dahlén, W. van der Flier, P. Scheltens, F. Duits, O. Hansson, C. Teunissen, Kaj Blennow, Henrik Zetterberg, Johan Gobom
Scientific Reports - 2017 -
Expanding the cerebrospinal fluid
endopeptidome
Karl Hansson, Tobias Skillbäck, Elin Pernevik, Silke Kern, Erik Portelius, Kina Höglund, Gunnar Brinkmalm, Jessica Holmén Larsson, Kaj Blennow, Henrik Zetterberg, Johan Gobom
Proteomics - 2017 -
Identification of candidate cerebrospinal fluid biomarkers in parkinsonism using quantitative
proteomics
N. K. Magdalinou, A. J. Noyce, R. Pinto, E. Lindström, Jessica Holmén Larsson, Mikko Hölttä, Kaj Blennow, H. R. Morris, Tobias Skillbäck, T. T. Warner, A. J. Lees, I. Pike, M. Ward, Henrik Zetterberg, Johan Gobom
Parkinsonism & Related Disorders - 2017 -
Ex vivo (18)O-labeling mass spectrometry identifies a peripheral amyloid β clearance
pathway.
Erik Portelius, Niklas Mattson, Josef Pannee, Henrik Zetterberg, Magnus Gisslén, Hugo Vanderstichele, Eleni Gkanatsiou, Gabriela A N Crespi, Michael W Parker, Luke A Miles, Johan Gobom, Kaj Blennow
Molecular neurodegeneration - 2017 -
Comprehensive Quantitative Profiling of Tau and Phosphorylated Tau Peptides in Cerebrospinal Fluid by Mass Spectrometry Provides New Biomarker
Candidates.
Claire L Russell, Vikram Mitra, Karl Hansson, Kaj Blennow, Johan Gobom, Henrik Zetterberg, Mikko Hiltunen, Malcolm Ward, Ian Pike
Journal of Alzheimer's disease : JAD - 2017 -
Proteomic studies of cerebrospinal fluid biomarkers of Alzheimer's disease: an
update.
Erik Portelius, Gunnar Brinkmalm, Josef Pannee, Henrik Zetterberg, Kaj Blennow, Rahil Dahlén, Ann Brinkmalm-Westman, Johan Gobom
Expert review of proteomics - 2017 -
A single dose of the gamma-secretase inhibitor semagacestat alters the cerebrospinal fluid peptidome in
humans
Mikko Hölttä, R. A. Dean, E. Siemers, K. G. Mawuenyega, W. Sigurdson, P. C. May, D. M. Holtzman, Erik Portelius, Henrik Zetterberg, R. J. Bateman, Kaj Blennow, Johan Gobom
Alzheimers Research & Therapy - 2016 -
Round robin test on quantification of amyloid-β 1-42 in cerebrospinal fluid by mass
spectrometry.
Josef Pannee, Johan Gobom, Leslie M Shaw, Magdalena Korecka, Erin E Chambers, Mary Lame, Rand Jenkins, William Mylott, Maria C Carrillo, Ingrid Zegers, Henrik Zetterberg, Kaj Blennow, Erik Portelius
Alzheimer's & dementia : the journal of the Alzheimer's Association - 2016 -
Reference measurement procedure for CSF Aβ1-42 and the CSF Aβ1-42 /Aβ1-40 ratio - a cross-validation study against Amyloid
PET.
Josef Pannee, Erik Portelius, Lennart Minthon, Johan Gobom, Ulf Andreasson, Henrik Zetterberg, Oskar Hansson, Kaj Blennow
Journal of neurochemistry - 2016 -
An integrated workflow for multiplex CSF proteomics and peptidomics - identification of candidate cerebrospinal fluid biomarkers of Alzheimer's
disease.
Mikko Hölttä, Lennart Minthon, Oscar Hansson, Jessica Holmén Larsson, Ian Pike, Malcolm Ward, Karsten Kuhn, Ulla Rüetschi, Henrik Zetterberg, Kaj Blennow, Johan Gobom
Journal of proteome research - 2015 -
Advancing cerebrospinal fluid biomarker discovery by mass
spectrometry
Johan Gobom
Neurodegenerative disease management - 2015 -
Explorative and targeted neuroproteomics in Alzheimer's
disease.
Ann Brinkmalm-Westman, Erik Portelius, Annika Öhrfelt, Gunnar Brinkmalm, Ulf Andreasson, Johan Gobom, Kaj Blennow, Henrik Zetterberg
Biochimica et biophysica acta - 2015 -
Mass spectrometry-based candidate reference measurement procedure for quantification of amyloid-β in cerebrospinal
fluid.
Andreas Leinenbach, Josef Pannee, Thomas Dülffer, Andreas Huber, Tobias Bittner, Ulf Andreasson, Johan Gobom, Henrik Zetterberg, Uwe Kobold, Erik Portelius, Kaj Blennow
Clinical chemistry - 2014 -
The amyloid-β degradation pattern in plasma-A possible tool for clinical trials in Alzheimer's
disease
Josef Pannee, Ulrika Törnqvist, Annie Westerlund, M. Ingelsson, L. Lannfelt, Gunnar Brinkmalm, Rita Persson, Johan Gobom, Johan Svensson, Per Johansson, Henrik Zetterberg, Kaj Blennow, Erik Portelius
Neuroscience Letters - 2014 -
Mass spectrometric characterization of amyloid-β species in the 7PA2 cell model of Alzheimer's
disease.
Erik Portelius, Maria Olsson, Gunnar Brinkmalm, Ulla Rüetschi, Niklas Mattsson, Ulf Andreasson, Johan Gobom, Ann Brinkmalm-Westman, Mikko Hölttä, Kaj Blennow, Henrik Zetterberg
Journal of Alzheimer's disease : JAD - 2013 -
A selected reaction monitoring (SRM)-based method for absolute quantification of Aβ38, Aβ40, and Aβ42 in cerebrospinal fluid of Alzheimer's Disease patients and healthy
controls.
Josef Pannee, Erik Portelius, Madalina Oppermann, Alan Atkins, Martin Hornshaw, Ingrid Zegers, Peter Höjrup, Lennart Minthon, Oskar Hansson, Henrik Zetterberg, Kaj Blennow, Johan Gobom
Journal of Alzheimer's Disease - 2013 -
Rapid development of sensitive, high-throughput, quantitative and highly selective mass spectrometric targeted immunoassays for clinically important proteins in human plasma and
serum
B. Krastins, A. Prakash, D. A. Sarracino, D. Nedelkov, E. E. Niederkofler, U. A. Kiernan, R. Nelson, M. S. Vogelsang, G. Vadali, A. Garces, J. N. Sutton, S. Peterman, G. Byram, B. Darbouret, J. R. Perusse, N. G. Seidah, B. Coulombe, Johan Gobom, Erik Portelius, Josef Pannee, Kaj Blennow, V. Kulasingam, L. Couchman, C. Moniz, M. F. Lopez
Clinical Biochemistry - 2013 -
Amyloid-β metabolism in Niemann-Pick C disease models and
patients.
Niklas Mattsson, Maria Olsson, Mikael K Gustavsson, Marko Kosicek, Martina Malnar, Jan-Eric Månsson, Maria K. Blomqvist, Johan Gobom, Ulf Andreasson, Gunnar Brinkmalm, Charles Vite, Silva Hecimovic, Caroline Hastings, Kaj Blennow, Henrik Zetterberg, Erik Portelius
Metabolic brain disease - 2012 -
Exhaled Endogenous Particles Contain Lung
Proteins.
Anna Bredberg, Johan Gobom, Ann-Charlotte Almstrand, Per Larsson, Kaj Blennow, Anna-Carin Olin, Ekaterina Mirgorodskaya
Clinical Chemistry - 2012 -
Reference measurement procedures for Alzheimer's disease cerebrospinal fluid biomarkers: definitions and approaches with focus on amyloid
β42.
Niklas Mattsson, Ingrid Zegers, Ulf Andreasson, Maria Bjerke, Marinus A Blankenstein, Robert Bowser, Maria C Carrillo, Johan Gobom, Theresa Heath, Rand Jenkins, Andreas Jeromin, June Kaplow, Daniel Kidd, Omar F Laterza, Andrew Lockhart, Michael P Lunn, Robert L Martone, Kevin Mills, Josef Pannee, Marianne Ratcliffe, Leslie M Shaw, Adam J Simon, Holly Soares, Charlotte E Teunissen, Marcel M Verbeek, Robert M Umek, Hugo Vanderstichele, Henrik Zetterberg, Kaj Blennow, Erik Portelius
Biomarkers in medicine - 2012 -
An online nano-LC-ESI-FTICR-MS method for comprehensive characterization of endogenous fragments from amyloid β and amyloid precursor protein in human and cat cerebrospinal
fluid.
Gunnar Brinkmalm, Erik Portelius, Annika Öhrfelt, Niklas Mattsson, Rita Persson, Mikael K Gustavsson, Charles H Vite, Johan Gobom, Jan-Eric Månsson, Jonas Nilsson, Adnan Halim, Göran Larson, Ulla Rüetschi, Henrik Zetterberg, Kaj Blennow, Ann Brinkmalm-Westman
Journal of mass spectrometry : JMS - 2012 -
Peptidome Analysis of Cerebrospinal Fluid by LC-MALDI
MS
Mikko Hölttä, Henrik Zetterberg, Ekaterina Mirgorodskaya, Niklas Mattsson, Kaj Blennow, Johan Gobom
Plos One - 2012 -
Neurogranin in cerebrospinal fluid as a marker of synaptic degeneration in Alzheimer's
disease.
Annika Thorsell, Maria Bjerke, Johan Gobom, Eva Brunhage, Eugeen Vanmechelen, Niels Andreasen, Oskar Hansson, Lennart Minthon, Henrik Zetterberg, Kaj Blennow
Brain research - 2010 -
Targeted proteomics in Alzheimer's disease: focus on
amyloid-beta.
Erik Portelius, Henrik Zetterberg, Johan Gobom, Ulf Andreasson, Kaj Blennow
Expert review of proteomics - 2008 -
Characterization of tau in cerebrospinal fluid using mass
spectrometry.
Erik Portelius, Sara Folkesson Hansson, Ai Jun Tran, Henrik Zetterberg, Pierre Grognet, Eugeen Vanmechelen, Kina Höglund, Gunnar Brinkmalm, Ann Brinkmalm-Westman, Eckhard Nordhoff, Kaj Blennow, Johan Gobom
Journal of proteome research - 2008