ForskarassistentAvd för medicinsk kemi och
Om Thaher Pelaseyed
Bacteria in our intestine exceed 10 trillions. In healthy individuals, an impermeable layer of secreted mucins separates bacteria from host intestinal cells.
In diseases such as Inflammatory bowel disease, bacteria breach the mucus barrier and reach epithelial cells covered with bottlebrush-like glycoproteins called transmembrane mucins. Despite the fact that transmembrane mucins extend up to 1 μm into the intestinal lumen and are ideal docking sites for penetrating bacteria, their biological function is unknown.
Our goal is to determine how transmembrane mucins sense bacteria and induce intestinal cell protection against bacterial infections.
Current funding and support: - Swedish Society for Medical Research, Start grant #S17-0005 (2018-2023) - NIH/NIAID/MIST Scholar Award in Mucosal Immunity (2018-2020) - Sahlgrenska Academy PhD Training Grant #U2018/162 (2019-2023) - The Wenner-Gren Foundations, Starting grant #FT2017-0002 (2017-2019) - The Wenner-Gren Foundations, International Postdoc Training grant, #UPD2018-0065 (2018-2020) - Åke Wiberg's Foundation, Research grant, #M17-0062 (2018-2019) - The Jeansson Foundations, Startup grant #JS2017-0003 (2018-2019)
Read more about our research and open positions here.
IL-22 promotes the formation of a MUC17 glycocalyx barrier in the postnatal small intestine during
Membrane mucins of the intestine at a
The human transmembrane mucin MUC17 responds to TNF alpha by increased presentation at the plasma
Regulation of actin-based apical structures on epithelial
Journal of Cell Science - 2018-01-01
Study of mucin turnover in the small intestine by in vivo
Ezrin activation by LOK phosphorylation involves a PIP2-dependent wedge
Thaher Pelaseyed, Raghuvir Viswanatha, Cécile Sauvanet, Joshua J Filter, Michael L Goldberg, Anthony Bretscher
eLife - 2017-01-01
Murine Butyrophilin-Like 1 and BtnI6 Form Heteromeric Complexes in Small Intestinal Epithelial Cells and Promote Proliferation of Local T
Cristina Lebrero-Fernandez, Joakim H. Bergström, Thaher Pelaseyed, Anna Bas-Forsberg
Frontiers in Immunology - 2016-01-01
Structure, regulation, and functional diversity of microvilli on the apical domain of epithelial
Cécile Sauvanet, Jessica Wayt, Thaher Pelaseyed, Anthony Bretscher
Annual review of cell and developmental biology - 2015-01-01
The mucus and mucins of the goblet cells and enterocytes provide the first defense line of the gastrointestinal tract and interact with the immune
Thaher Pelaseyed, Joakim H. Bergström, Jenny K Gustafsson, Anna Ermund, George M. H. Birchenough, André Schütte, Sjoerd van der Post, Frida Svensson, Ana María Rodríguez-Piñeiro, Elisabeth E. L. Nyström, Catharina Wising, Malin E V Johansson, Gunnar C. Hansson
Immunological Reviews - 2014-01-01
Carbachol-induced MUC17 endocytosis is concomitant with NHE3 internalization and CFTR membrane recruitment in
Unfolding dynamics of the mucin SEA domain probed by force spectroscopy suggest that it acts as a cell-protective
The Relationship between Transmembrane Mucins, Ion Channels and PDZ Adaptor Proteins in the Small
Composition and functional role of the mucus layers in the
Malin E V Johansson, Daniel Ambort, Thaher Pelaseyed, André Schütte, Jenny K Gustafsson, Anna Ermund, Durai B Subramani, Jessica Holmén Larsson, Kristina A Thomsson, Joakim H. Bergström, Sjoerd van der Post, Ana María Rodríguez-Piñeiro, Henrik Sjövall, Malin Bäckström, Gunnar C. Hansson
Cellular and Molecular Life Sciences - 2011-01-01
CFTR anion channel modulates expression of human transmembrane mucin MUC3 through the PDZ protein
The C-terminus of the transmembrane mucin MUC17 binds to the scaffold protein PDZK1 that stably localizes it to the enterocyte apical membrane in the small