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George Birchenough
Universitetslektor
Avd för medicinsk kemi och cellbiologiOm George Birchenough
Mitt forskningsprogram försöker utveckla vår förståelse av slemhinnor genom identifiering och karakterisering av de defensiva systemen som reglerar våra interaktioner med mikroorganismer.
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Cross-kingdom-mediated detection of intestinal protozoa through
NLRP6
Nathaniel J. Winsor, Giuliano Bayer, Ojas Singh, Jeremy K. Chan, Lu Yi Li, Brandon Y. Lieng, Elisabeth Foerster, Ana Popovic, Boyan K. Tsankov, Heather Maughan, Paul Lemire, Elaine Tam, Catherine Streutker, Lina Chen, Stacey L. Heaver, Ruth E. Ley, John Parkinson, J. Rafael Montenegro-Burke, George M. H. Birchenough, Dana J. Philpott, Stephen E. Girardin
CELL HOST & MICROBE - 2025 -
Mechanisms of uropathogenic <i>E. coli</i> mucosal association in the gastrointestinal
tract
Philippe N. Azimzadeh, George M. H. Birchenough, Nathaniel C. Gualbuerto, Jerome S. Pinkner, Kevin O. Tamadonfar, Wandy Beatty, Thomas J. Hannan, Karen W. Dodson, Enid C. Ibarra, Seonyoung Kim, Henry L. Schreiber, James W. Janetka, Andrew L. Kau, Ashlee M. Earl, Mark J. Miller, Gunnar C. Hansson, Scott J. Hultgren
SCIENCE ADVANCES - 2025 -
Antenatal <i>Ureaplasma</i> Infection Causes Colonic Mucus Barrier Defects: Implications for Intestinal
Pathologies
Charlotte van Gorp, Ilse H. de Lange, Matthias C. Hutten, Carmen Lopez-Iglesias, Kimberly R. I. Massy, Lilian Kessels, Kevin Knoops, Iris Cuijpers, Mireille M. J. P. E. Sthijns, Freddy J. Troost, Wim G. van Gemert, Owen B. Spiller, George M. H. Birchenough, Luc J. I. Zimmermann, Tim G. A. M. Wolfs
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES - 2024 -
Low-grade intestinal inflammation two decades after pelvic
radiotherapy.
Sravani Devarakonda, Annika Thorsell, Per Hedenström, Azar Rezapour, Lisen Heden, Sanghita Banerjee, Malin E V Johansson, George M. H. Birchenough, Amelie Toft Morén, Karin Gustavsson, Viktor Skokic, Victor L Pettersson, F. Sjöberg, Marie Kalm, Mohammad Al Masri, Michaela Ekh, Henrik Fagman, Mats Wolving, Rosie Perkins, Rodrigo A Morales, Francisca Castillo, Eduardo J Villablanca, Ulf Yrlid, Karin Bergmark, Gunnar Steineck, Cecilia Bull
EBioMedicine - 2023 -
Muc2-dependent microbial colonization of the jejunal mucus layer is diet sensitive and confers local resistance to enteric pathogen
infection
George M. H. Birchenough, Björn O. Schröder, Sinan Sharba, Liisa Arike, Christian V Recktenwald, F. Puertolas-Balint, Mahadevan Subramani, Karl Hansson, B. Yilmaz, Sara K. Lindén, Fredrik Bäckhed, Gunnar C. Hansson
Cell Reports - 2023 -
Microbial experience through housing in a farmyard-type environment alters intestinal barrier properties in mouse
colons
H. Arnesen, T. Markussen, George M. H. Birchenough, S. Birkeland, Elisabeth E. L. Nyström, Gunnar C. Hansson, H. Carlsen, P. Boysen
Scientific Reports - 2023 -
Trans-Golgi protein TVP23B regulates host-microbe interactions via Paneth cell homeostasis and Goblet cell
glycosylation
R. Song, W. McAlpine, A. M. Fond, E. Nair-Gill, J. H. Choi, E. E. L. Nystrom, Liisa Arike, S. Field, X. H. Li, J. A. SoRelle, J. J. Moresco, E. M. Y. Moresco, J. R. Yates, P. Azadi, J. Ni, George M. H. Birchenough, B. Beutler, E. E. Turer
Nature Communications - 2023 -
Antenatal Ureaplasma infection induces ovine small intestinal goblet cell defects: a strong link with NEC
pathology
C. van Gorp, I. H. de Lange, M. C. Hutten, C. Lopez-Iglesias, K. Massy, L. Kessels, B. Kramer, W. van de Wetering, B. Spiller, George M. H. Birchenough, W. G. van Gemert, L. J. Zimmermann, T. Wolfs
Tissue Barriers - 2022 -
Transglutaminase 3 crosslinks the secreted gel-forming mucus component Mucin-2 and stabilizes the colonic mucus
layer
Jack D. A. Sharpen, Brendan Dolan, Elisabeth E. L. Nyström, George M. H. Birchenough, Liisa Arike, Beatriz Martinez Abad, Malin E V Johansson, Gunnar C. Hansson, Christian V Recktenwald
Nature Communications - 2022 -
Rainbow trout gastrointestinal mucus, mucin production, mucin glycosylation and response to
lipopolysaccharide
Sinan Sharba, Henrik Sundh, Kristina Sundell, John Benktander, Licínia Santos, George M. H. Birchenough, Sara K. Lindén
Fish and Shellfish Immunology - 2022 -
An intercrypt subpopulation of goblet cells is essential for colonic mucus barrier
function
Elisabeth E. L. Nyström, Beatriz Martinez Abad, Liisa Arike, George M. H. Birchenough, E. B. Nonnecke, P. A. Castillo, Frida Svensson, C. L. Bevins, Gunnar C. Hansson, Malin E V Johansson
Science - 2021 -
NOX1-dependent redox signaling potentiates colonic stem cell proliferation to adapt to the intestinal microbiota by linking EGFR and TLR
activation
Sjoerd van der Post, George M. H. Birchenough, J. M. Held
Cell Reports - 2021 -
Forming a mucus barrier along the
colon
George M. H. Birchenough, Malin E V Johansson
Science - 2020 -
Gill Mucus and Gill Mucin O-glycosylation in Healthy and Amebic Gill Disease-Affected Atlantic
Salmon.
John Benktander, János T Padra, Ben Maynard, George M. H. Birchenough, Natasha A Botwright, Russel McCulloch, James W Wynne, Sinan Sharba, Kristina Sundell, Henrik Sundh, Sara K. Lindén
Microorganisms - 2020 -
Obesity-associated microbiota contributes to mucus layer defects in genetically obese
mice
Björn O. Schröder, George M. H. Birchenough, Meenakshi Pradhan, Elisabeth E. L. Nyström, Marcus Henricsson, Gunnar C. Hansson, Fredrik Bäckhed
Journal of Biological Chemistry - 2020 -
The Nlrp6 inflammasome is not required for baseline colonic inner mucus layer formation or
function
Joana K. Volk, Elisabeth E. L. Nyström, Sjoerd van der Post, Beatriz Martinez Abad, Björn O. Schröder, Åsa Johansson, Frida Svensson, Sofia Jäverfelt, Malin E V Johansson, Gunnar C. Hansson, George M. H. Birchenough
Journal of Experimental Medicine - 2019 -
Loss of Trefoil Factor 2 Sensitizes Rat Pups to Systemic Infection with the Neonatal Pathogen Escherichia coli
K1
A. J. McCarthy, George M. H. Birchenough, P. W. Taylor
Infection and Immunity - 2019 -
Dietary destabilisation of the balance between the microbiota and the colonic mucus
barrier
George M. H. Birchenough, Björn O. Schröder, Fredrik Bäckhed, Gunnar C. Hansson
Gut microbes - 2019 -
Structural weakening of the colonic mucus barrier is an early event in ulcerative colitis
pathogenesis
Sjoerd van der Post, Karolina S. Jabbar, George M. H. Birchenough, Liisa Arike, Noreen Akhtar, Henrik Sjövall, Malin E V Johansson, Gunnar C. Hansson
Gut - 2019 -
Bifidobacteria or Fiber Protects against Diet-Induced Microbiota-Mediated Colonic Mucus
Deterioration
Björn O. Schröder, George M. H. Birchenough, Marcus Ståhlman, Liisa Arike, Malin E V Johansson, Gunnar C. Hansson, Fredrik Bäckhed
Cell Host & Microbe - 2018 -
Calcium-activated Chloride Channel Regulator 1 (CLCA1) Controls Mucus Expansion in Colon by Proteolytic
Activity
Elisabeth E. L. Nyström, George M. H. Birchenough, Sjoerd van der Post, Liisa Arike, A. D. Gruber, Gunnar C. Hansson, Malin E V Johansson
Ebiomedicine - 2018 -
Postnatal development of the small intestinal mucosa drives age-dependent, regio-selective susceptibility to Escherichia coli K1
infection
George M. H. Birchenough, F. Dalgakiran, L. A. Witcomb, Malin E V Johansson, A. J. McCarthy, Gunnar C. Hansson, P. W. Taylor
Scientific Reports - 2017 -
Functional mucous layer and healing of proximal colonic anastomoses in an experimental
model.
J W A M Bosmans, A C H M Jongen, George M. H. Birchenough, Elisabeth E. L. Nyström, M J J Gijbels, J P M Derikx, N D Bouvy, Gunnar C. Hansson
The British journal of surgery - 2017 -
Gram-positive bacteria are held at a distance in the colon mucus by the lectin-like protein
ZG16.
Joakim H. Bergström, George M. H. Birchenough, Gergely Katona, Björn O. Schröder, André Schütte, Anna Ermund, Malin E V Johansson, Gunnar C. Hansson
Proceedings of the National Academy of Sciences of the United States of America - 2016 -
A sentinel goblet cell guards the colonic crypt by triggering Nlrp6-dependent Muc2
secretion
George M. H. Birchenough, Elisabeth E. L. Nyström, Malin E V Johansson, Gunnar C. Hansson
Science - 2016 -
The Goblet Cell Protein Clca1 (Alias mClca3 or Gob-5) Is Not Required for Intestinal Mucus Synthesis, Structure and Barrier Function in Naive or DSS-Challenged
Mice
N. A. Erickson, Elisabeth E. L. Nyström, L. Mundhenk, Liisa Arike, R. Glauben, M. M. Heimesaat, A. Fischer, S. Bereswill, George M. H. Birchenough, A. D. Gruber, Malin E V Johansson
Plos One - 2015 -
New developments in goblet cell mucus secretion and
function
George M. H. Birchenough, Malin E V Johansson, Jenny K Gustafsson, Joakim H. Bergström, Gunnar C. Hansson
Mucosal Immunology - 2015 -
The mucus and mucins of the goblet cells and enterocytes provide the first defense line of the gastrointestinal tract and interact with the immune
system
Thaher Pelaseyed, Joakim H. Bergström, Jenny K Gustafsson, Anna Ermund, George M. H. Birchenough, André Schütte, Sjoerd van der Post, Frida Svensson, Ana María Rodríguez-Piñeiro, Elisabeth E. L. Nyström, Catharina Wising, Malin E V Johansson, Gunnar C. Hansson
Immunological Reviews - 2014 -
Non-Invasive Model of Neuropathogenic Escherichia coli Infection in the Neonatal
Rat
F. Dalgakiran, L. A. Witcomb, A. J. McCarthy, George M. H. Birchenough, P. W. Taylor
Jove-Journal of Visualized Experiments - 2014 -
Altered innate defenses in the neonatal gastrointestinal tract in response to colonization by neuropathogenic Escherichia
coli.
George M. H. Birchenough, Malin E V Johansson, Richard A Stabler, Fatma Dalgakiran, Gunnar C. Hansson, Brendan W Wren, J Paul Luzio, Peter W Taylor
Infection and immunity - 2013 -
Altered Innate Defenses in the Neonatal Gastrointestinal Tract in Response to Colonization by Neuropathogenic Escherichia
coli
George M. H. Birchenough, Malin E V Johansson, R. A. Stabler, F. Dalgakiran, Gunnar C. Hansson, B. W. Wren, J. P. Luzio, P. W. Taylor
Infection and Immunity - 2013