AstraZeneca Collaborations
The WCMTM initiative is part of intensifying the collaboration between industry, academia and healthcare to make Sweden and the Nordic region an even more attractive life-science cluster.
Combining academic research and industry is a way to ensure that research results become the best possible outcome for patients, for example through novel therapies. This is one of the intentions with the close collaboration between WCMTM and AstraZeneca.
AstraZeneca is a scientifically driven major pharmaceutical company, and one of the world leaders in the treatment of heart and respiratory diseases, and cancer. The research team in Sweden consists of talented and credible scientist, with significant international reputation – creating a perfect match for the promising, young researchers recruited to WCMTM. Together we explore collaborations and find synergies in our research fields for the benefit of patients.
Joint Post doc Program
Within the AstraZeneca and WCMTM framework, a joint post doc program has been initiated with several projects being conducted or have been finished. Below you can find a summary of our ongoing projects.
Pernille B. Laerkegaard Hansen
Kaushik Sengupta
IgA nephropathy- multiomics and the role of glomerular crosstalk
AstraZeneca PI: Pernille Laerkegaard Hansen
GU PI: Jenny Nyström
Post doc: Gayathri Narasimhan
Project Aims:
1. Understanding the molecular mechanisms behind IgA nephropathy though a multiomics approach
2. Study the cell-cell interactions between mesangial cells and podocytes in IgA nephropathy
Understanding the mechanism of RNAi machinery in the nucleus
AstraZeneca PI: Annabelle Biscans
GU PI: Aishe Sarshad
Post doc: Evgeniia Shcherbinina
Project Aims:
1. Understanding the molecular mechanism of siRNA-mediated silencing of exclusively nuclear lncRNAs and introns within pre-mRNAs
2. Determine the role of nuclear AGO2 in gene regulation
Functional genomics approaches for finding novel drug sensitivity and resistance mechanisms in Kras-driven lung and pancreatic cancer
AstraZeneca PI: Marcello Maresca
GU PI: Volkan Sayin
Post doc: Nadia Gul
Physiological profiling of proximal tubular epithelial cells during injury and repair
AstraZeneca PI: Julie Williams
GU PI: Joan Camuñas-Soler
Post doc: Yike Xie
Project Aim: Understanding the physiology of proximal tubular epithelial cells (PTECs) during injury and repair by novel methods combining cellular function measurements with single-cell transcriptomics
Kidney physiology and pathology with a focus on kidney regeneration
Pernille Laerkegaard Hansen (AstraZeneca) and Jenny Nyström (GU)
Degenerative diseases and the role of inflammation
Anetta Härtlova (GU), Melker Göransson, (AstraZeneca) and Julie Williams (AstraZeneca)
Method development for chemical modifications and bio-conjugation of peptides, proteins, antibodies or oligonucleotides in ionic liquids
Alesia Tietze (GU), Malin Lemurell (AstraZeneca) and Werngard Czechtizky (AstraZeneca)
Mechanisms of genetic and epigenetic regulation in asthma: applications for precision medicine and patient stratification
Madeleine Rådinger (GU) and Sophia Blake (AstraZeneca)
Functional genomics approaches for finding novel drug sensitivity and resistance mechanisms in Kras-driven lung and pancreatic cancer
Volkan Sayin (GU) and Marcello Maresca (AstraZeneca)