University of Gothenburg

Key Publications

Here are some of Wallenberg Centre's researchers' publications in recent years.


Lipid and glucose metabolism in white adipocytes: pathways, dysfunction and therapeutics.
Morigny P, Boucher J, Arner P, Langin D. 
Nat Rev Endocrinol. 2021 May;17(5):276-295. 

Plasma p-tau231: a new biomarker for incipient Alzheimer's disease pathology. 
Ashton NJ, Pascoal TA, Karikari TK, Benedet AL, Lantero-Rodriguez J, Brinkmalm G, Snellman A, Schöll M, Troakes C, Hye A, Gauthier S, Vanmechelen E, Zetterberg H, Rosa-Neto P, Blennow K. 
Acta Neuropathol. 2021 May;141(5):709-724. 

Bi-allelic VPS16 variants limit HOPS/CORVET levels and cause a mucopolysaccharidosis-like disease. 
Sofou K, Meier K, Sanderson LE, Kaminski D, Montoliu-Gaya L, Samuelsson E, Blomqvist M, Agholme L, Gärtner J, Mühlhausen C, Darin N, Barakat TS, Schlotawa L, van Ham T, Asin Cayuela J, Sterky FH
EMBO Mol Med. 2021 May 7;13(5):e13376. 

Recovery after breast cancer surgery following a recommendation of physical activity pre- and postoperatively (PhysSURG-B)-a randomized clinical trial. 
Heiman J, Haglind E, Olofsson Bagge R
Br J Surg. 2021 May 5:znab136. 

CA10 regulates neurexin heparan sulfate addition via a direct binding in the secretory pathway. 
Montoliu-Gaya L, Tietze D, Kaminski D, Mirgorodskaya E, Tietze AA, Sterky FH
EMBO Rep. 2021 Apr 7;22(4):e51349. 

Post-traumatic epilepsy in adults: a nationwide register-based study. 
Karlander M, Ljungqvist J, Zelano J
J Neurol Neurosurg Psychiatry. 2021 Mar 9;92(6):617-21. 

Argonaute Proteins Take Center Stage in Cancers. 
Nowak I, Sarshad AA
Cancers (Basel). 2021 Feb 13;13(4):788. 

Reduced [18F]flortaucipir retention in white matter hyperintensities compared to normal-appearing white matter.
Moscoso A, Grothe MJ, Schöll M; Alzheimer’s Disease Neuroimaging Initiative. 
Eur J Nucl Med Mol Imaging. 2021 Jan 21. 

Prehospital lactate levels in blood as a seizure biomarker: A multi-center observational study.
Magnusson C, Herlitz J, Höglind R, Wennberg P, Edelvik Tranberg A, Axelsson C, Zelano J. Epilepsia. 2021 Jan 8. 

Longitudinal Associations of Blood Phosphorylated Tau181 and Neurofilament Light Chain With Neurodegeneration in Alzheimer Disease. 
Moscoso A, Grothe MJ, Ashton NJ, Karikari TK, Lantero Rodríguez J, Snellman A, Suárez-Calvet M, Blennow K, Zetterberg H, Schöll M; Alzheimer’s Disease Neuroimaging Initiative. JAMA Neurol. 2021 Jan 11:e204986.


Preparation of Bacterial Outer Membrane Vesicles for Characterisation of Periplasmic Proteins in Their Native Environment. 
Thoma J, Burmann BM
Bio Protoc. 2020 Dec 20;10(24):e3853. 

Epilepsy after brain infection in adults: A register-based population-wide study. 
Zelano J, Westman G. 
Neurology. 2020 Dec 15;95(24):e3213-e3220. 

Hormone replacement therapy and asthma onset in menopausal women: National cohort study. 
Shah SA, Tibble H, Pillinger R, McLean S, Ryan D, Critchley H, Price D, Hawrylowicz CM, Simpson CR, Soyiri IN, Appiagyei F, Sheikh A, Nwaru BI.  
J Allergy Clin Immunol. 2020 Dec 3:S0091-6749(20)31697-3. 

Time course of phosphorylated-tau181 in blood across the Alzheimer's disease spectrum. Moscoso A, Grothe MJ, Ashton NJ, Karikari TK, Rodriguez JL, Snellman A, Suárez-Calvet M, Zetterberg H, Blennow K, Schöll M; Alzheimer’s Disease Neuroimaging Initiative. 
Brain. 2020 Nov 30:awaa399. 

Hormonal contraception and the risk of severe asthma exacerbation: 17-year population-based cohort study. 
Nwaru BI, Tibble H, Shah SA, Pillinger R, McLean S, Ryan DP, Critchley H, Price DB, Hawrylowicz CM, Simpson CR, Soyiri IN, Appiagyei F, Sheikh A. 
Thorax. 2020 Nov 23:thoraxjnl-2020-215540. 

The Effect of Beta-Adrenergic Blocking Agents in Cutaneous Melanoma-A Nation-Wide Swedish Population-Based Retrospective Register Study.
Katsarelias D, Eriksson H, Mikiver R, Krakowski I, Nilsson JA, Ny L, Olofsson Bagge R.
Cancers (Basel). 2020 Nov 2;12(11):E3228.

UvrD helicase-RNA polymerase interactions are governed by UvrD's carboxy-terminal Tudor domain.
Kawale AA, Burmann BM.
Commun Biol. 2020 Oct 23;3(1):607.
Ultrasensitive DNA Immune Repertoire Sequencing Using Unique Molecular Identifiers.
Johansson G, Kaltak M, Rîmniceanu C, Singh AK, Lycke J, Malmeström C, Hühn M, Vaarala O, Cardell S, Ståhlberg A.
Clin Chem. 2020 Sep 1;66(9):1228-1237.
An Obesogenic Dietary Mouse Model of Nonalcoholic Steatohepatitis.
Zarrouki B, Boucher J.
Methods Mol Biol. 2020;2164:121-127.

Recording in-cell NMR-spectra in living mammalian cells.
Matečko-Burmann, I., Burmann, BM
Methods Mol. Biol. July 2020, 2141. 

Blood phosphorylated tau 181 as a biomarker for Alzheimer's disease: a diagnostic performance and prediction modelling study using data from four prospective cohorts.
Karikari TK, Pascoal TA, Ashton NJ, Janelidze S, Benedet AL, Rodriguez JL, Chamoun M, Savard M, Kang MS, Therriault J, Schöll M, Massarweh G, Soucy J, Höglund K, Brinkmalm G, Mattsson N, Palmqvist S, Gauthier S, Stomrud E, Zetterberg H, Hansson O, Rosa-Neto P, Blennow K.
Lancet Neurology. May 2020, Vol 19, issue 5, P422-433.

An update on blood-based biomarkers for non-Alzheimer neurodegenerative disorders.
Ashton NJ, Hye A, Rajkumar AP, Leuzy A, Snowden S, Suárez-Calvet M, Karikari TK, Schöll M, La Joie R, Rabinovici GD, Höglund K, Ballard C, Hortobágyi T, Svenningsson P, Blennow K, Zetterberg H, Aarsland D.
Nat Rev Neurol. 2020 May;16(5):265-284.

Hormonal contraceptives and onset of asthma in reproductive-age women: Population-based cohort study. 
Nwaru BI, Pillinger R, Tibble H, Shah SA, Ryan D, Critchley H, Price D, Hawrylowicz CM, Simpson CR, Soyiri IN, Appiagyei F, Sheikh A.
J Allergy Clin Immunol. 2020 Apr 9. 

Liquid biopsy analysis in cancer diagnostics.
Andersson D, Kubista M, Ståhlberg A.
Mol Aspects Med. 2020 Apr;72:100839. 

Circulating cell-free tumor DNA analysis in pediatric cancers. 
Andersson D, Fagman H, Dalin MG, Ståhlberg A.
Mol Aspects Med. 2020 Apr;72:100819. 

Patient-derived scaffolds uncover breast cancer promoting properties of the microenvironment.
Landberg G, Fitzpatrick P, Isakson P, Jonasson E, Karlsson J, Larsson E, Svanström A, Rafnsdottir S, Persson E, Gustafsson A, Andersson D, Rosendahl J, Petronis S, Ranji P, Gregersson P, Magnusson Y, Håkansson J, Ståhlberg A.
Biomaterials. 2020 Mar;235:119705. 

Ultrasensitive and selective copper (II) detection: introducing a bioinspired and robust sensor.
Müller LK, Duznovic I, Tietze D, Weber W, Ali M, Stein V, Ensinger W, Tietze A.
Chemistry. 2020 Mar 20. 

Maternal iron supplementation in pregnancy and asthma in the offspring: follow-up of a randomised trial in Finland. 
Shaheen SO, Gissler M, Devereux G, Erkkola M, Kinnunen TI, Mcardle H, Sheikh A, Hemminki E, Nwaru BI.
Eur Respir J. 2020 Mar 5. 

Effect of delay between nuclear medicine scanning and sentinel node biopsy on outcome in patients with cutaneous melanoma. 
Moncrieff MD, O'Leary FM, Beadsmoore CJ, Pawaroo D, Heaton MJ, Isaksson K, Olofsson Bagge R.
Br J Surg. 2020 Feb 19.

Activation of Oxidative Stress Response in Cancer Generates a Druggable Dependency on Exogenous Non-essential Amino Acids.
LeBoeuf SE, Wu WL, Karakousi TR, Karadal B, Jackson SR, Davidson SM, Wong KK, Koralov SB, Sayin VI, Papagiannakopoulos T.
Cell Metab. 2020 Feb 4;31(2):339-350.e4. 

Bariatric surgery and the incidence of rheumatoid arthritis - a Swedish Obese Subjects study. Rheumatology (Oxford).
Maglio C, Zhang Y, Peltonen M, Andersson-Assarsson J, Svensson PA, Herder C, Rudin A, Carlsson L.
2020 Feb 1;59(2):303-309. 

Regulation of α-synuclein by chaperones in mammalian cells.
Burmann BM, Gerez JA, Matečko-Burmann I, Campioni S, Kumari P, Ghosh D, Mazur A, Aspholm EE, Šulskis D, Wawrzyniuk M, Bock T, Schmidt A, Rüdiger SGD, Riek R, Hiller S.
Nature. 2020 Jan;577(7788):127-132. 

Does early cognitive decline require the presence of both tau and amyloid-β?
Schöll M, Maass A.
Brain. 2020 Jan 1;143(1):10-13. 

Overuse of short-acting β(2)-agonists in asthma is associated with increased risk of exacerbation and mortality: A nationwide cohort study of the global SABINA programme.
Nwaru BI, Ekström M, Hasvold P, Wiklund F, Telg G, Janson C.
Eur Respir J. 2020 Jan 16. 


Regional times to equilibria and their impact on semi-quantification of [(18)F]AV-1451 uptake
Heurling K, Smith R, Strandberg OT, Schain M, Ohlsson T, Hansson O, Schöll M..
J Cereb Blood Flow Metab. 2019 Nov;39(11):2223-2232. 

Propagation of Tau Pathology: Integrating Insights From Postmortem and In Vivo Studies.
Vogels T, Leuzy A, Cicognola C, Ashton NJ, Smolek T, Novak M, Blennow K, Zetterberg H, Hromadka T, Zilka N, Schöll M
Biol Psychiatry. 2019 Oct 3. pii: S0006-3223(19)31744-5.

Targeting Metabolic Bottlenecks in Lung Cancer.
Sayin VI, LeBoeuf SE, Papagiannakopoulos T. 
Trends Cancer. 2019 Aug;5(8):457-459. 

JAK-STAT signalling controls cancer stem cell properties including chemotherapy resistance in myxoid liposarcoma.
Dolatabadi S, Jonasson E, Lindén M, Fereydouni B, Bäcksten K, Nilsson M, Martner A, Forootan A, Fagman H, Landberg G, Åman P, Ståhlberg A.
Int J Cancer. 2019 Jul 15;145(2):435-449.

BACH1 Stabilization by Antioxidants Stimulates Lung Cancer Metastasis.
Wiel C, Le Gal K, Ibrahim MX, Jahangir CA, Kashif M, Yao H, Ziegler DV, Xu X, Ghosh T, Mondal T, Kanduri C, Lindahl P, Sayin VI*, Bergo MO.
Cell. 2019 Jul 11;178(2):330-345.e22. 
*co-corresponding author

Triggering MSR1 promotes JNK-mediated inflammation in IL-4-activated macrophages.
Guo M', Härtlova A*', Gierliński M, Prescott A, Castellvi J, Losa JH, Petersen SK, Wenzel UA, Dill BD, Emmerich CH, Ramon Y Cajal S, Russell DG, Trost M.*
EMBO J. 2019 Jun 3;38(11).
'contributed equally, *co-corresponding author.

Furry Animal Allergen Component Sensitization and Clinical Outcomes in Adult Asthma and Rhinitis.
Nwaru BI, Suzuki S, Ekerljung L, Sjölander S, Mincheva R, Rönmark EP, Rådinger M, Rönmark E, Borres MP, Lundbäck B, Lötvall J.
J Allergy Clin Immunol Pract. 2019 Apr;7(4):1230-1238.e4. 

Mature Human White Adipocytes Cultured under Membranes Maintain Identity, Function, and Can Transdifferentiate into Brown-like Adipocytes.
Harms MJ, Li Q, Lee S, Zhang C, Kull B, Hallen S, Thorell A, Alexandersson I, Hagberg CE, Peng XR, Mardinoglu A, Spalding KL, Boucher J.
Cell Rep. 2019 Apr 2;27(1):213-225.e5.

FET family fusion oncoproteins target and compromise the SWI/SNF chromatin remodeling complex.
Lindén M, Thomsen C, Grundevik P, Jonasson E, Andersson D, Runnberg R, Dolatabadi S, Vannas C, Luna Santa Maria M, Fagman H, Ståhlberg A*, Åman P*.
EMBO Reports, 2019
* Joint principal investigator

Parabrachial Interleukin-6 Reduces Body Weight and Food Intake and Increases Thermogenesis to Regulate Energy Metabolism.
Mishra D, Richard JE, Maric I, Porteiro B, Häring M, Kooijman S, Musovic S, Eerola K, López-Ferreras L, Peris E, Grycel K, Shevchouk OT, Micallef P, Olofsson CS, Wernstedt Asterholm I, Grill HJ, Nogueiras R, Skibicka KP.
Cell Rep. 2019 Mar 12;26(11):3011-3026.e5.


Discriminative Accuracy of [18F]flortaucipir Positron Emission Tomography for Alzheimer Disease vs Other Neurodegenerative Disorders.
Ossenkoppele R, Rabinovici GD, Smith R, Cho H, Schöll M, Strandberg O, Palmqvist S, Mattsson N, Janelidze S, Santillo A, Ohlsson T, Jögi J, Tsai R, La Joie R, Kramer J, Boxer AL, Gorno-Tempini ML, Miller BL, Choi JY, Ryu YH, Lyoo CH, Hansson O.
Jama, 2018. 320(11): p. 1151-1162.

Clustering of adult-onset diabetes into novel subgroups provides improved prediction of outcome.
Ahlqvist E, Storm P, Käräjämäki A, Martinell M, Dorkhan M, Carlsson A, Vikman P, Prasad RB, Aly DM, Almgren P, Wessman Y, Shaat N, Spégel P, Mulder H, Lindholm E, Melander O, Hansson O, Malmqvist U, Lernmark Å, Lahti K, Forsén T, Tuomi T, Rosengren AH, Groop L.
Lancet Diabetes and Endocrinology. 2018 May;6(5):361-369.

Lateral hypothalamic GLP-1 receptors are critical for the control of food reinforcement, ingestive behavior and body weight
López-Ferreras L, Richard JE, Noble E, Eerola K, Anderberg RH, Nilsson FH, Olandersson K, Kanoski SE, Hayes MR, Skibicka KP.
Mol Psychiatry. 2018 May;23(5):1157-1168.


Transcriptomic characterization of the human cell cycle in individual unsynchronized cells. 
Karlsson J, Kroneis T, Jonasson E, Larsson E, Ståhlberg A
J Mol Biol. 2017 Dec 8;429(24):3909-3924. 

Can learning health systems help organisations deliver personalised care? 
Nwaru BI, Friedman C, Halamka J, Sheikh A. 
BMC Med. 2017 Oct 2;15(1):177.

Sulforaphane reduces hepatic glucose production and improves glucose control in patients with type 2 diabetes
Axelsson AS, Tubbs E, Mecham B, Chacko S, Nenonen HA, Tang Y, Fahey JW, Derry JMJ, Wollheim CB, Wierup N, Haymond MW, Friend SH, Mulder H, Rosengren AH
Sci Transl Med. 2017 Jun 14;9(394). 

Sox5 regulates adult beta-cell phenotype and is reduced in type 2 diabetes
Axelsson AS, Mahdi T, Nenonen HA, Hänzelmann S, Bagge A, Wendt A, Reinbothe TM, Millstein J, Yang X, Zhang B, Gusmao EG, Shu L, Tang Y, Wang J, Andersson SE, Eliasson L, Artner I, Wollheim CB, Derry JM, Mecham B, Spégel P, Mulder H, Gesteira Costa Filho I, Zhang E, Rosengren AH
Nat Commun, Jun 6;8:15652 2017

Distinct 18F-AV-1451 tau PET retention patterns in early- and late-onset Alzheimer's disease.
Schöll M, Ossenkoppele R, Strandberg O, Palmqvist S; Swedish BioFINDER study, Jögi J, Ohlsson T, Smith R, Hansson O.
Brain, 2017. 140(9): p. 2286-2294.

AICAR ameliorates high-fat diet-associated pathophysiology in mouse and ex vivo models, independent of adiponectin.
Börgeson E, Wallenius V, Syed GH, Darshi M, Lantero Rodriguez J, Biörserud C, Ragnmark Ek M, Björklund P, Quiding-Järbrink M, Fändriks L, Godson C, Sharma K.
Diabetologia. 2017 Apr;60(4):729-739.