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Per Larsson - University of Gothenburg, Sweden Till startsida
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Per Larsson

Postdoctor

Per Larsson
Postdoctor
per.larsson@amm.gu.se

Postal Address: Box 414, 40530 Göteborg
Visiting Address: Medicinaregatan 16 , 41390 Göteborg


Department of Public Health and Community Medicine at Institute of Medicine (More Information)
Box 414
405 30 Göteborg
Visiting Address: Medicinaregatan 16 , 413 90 Göteborg

About Per Larsson

I have an MSc in chemistry with emphasis towards analytical chemistry and biochemistry. After finishing my MSc in 2006 I was employed as chemist by Sahlgrenska Universitetssjukhuset for a few years before I was given the opportunity to become a full time PhD student at the Department of Public Health and Community Medicine in 2010. The focus of our research group is biomarkers and airway inflammation. Chronic airway inflammation is associated to many common airway diseases such as asthma and COPD yet there is no widely applicable method for early detection and monitoring of small airway inflammation at present. To address this, we have developed a new method to obtain samples of the respiratory tract lining fluid that covers the small airways. The method is based on sampling of small airborne droplets that are formed from the fluid in the small airways, and in particular during a certain breathing maneuver. The droplets are small enough to be carried in the exhaled air from the small airways to the mouth where they can be sampled conveniently. We have developed an instrument with the purpose of quantifying the amount of exhaled droplets while at the same time collecting them for chemical analysis. Because the droplets are formed in the small airways they are considered to have a chemical composition that is representative of the respiratory lining fluid in small airways and are likely to contain biomarkers that reflects the inflammatory condition. My research focus is on both sampling and analyzing the exhaled droplets. Currently we have a few analytical methods that have been validated and are being used in clinical studies with promising results.
A particularly interesting project that I am now working on is to analyze surfactant protein A by SRM/MRM mass spectrometry. The purpose is to cross validate the immunological method that we are using today and also to study how structural variations can influence the immunological functions of the protein.
 

Latest publications

Two techniques to sample non-volatiles in breath-exemplified by methadone.
Göran Ljungkvist, Shahid Ullah, Åsa Tinglev, Karina Stein, Björn Bake et al.
Journal of breath research, Journal article 2018
Journal article

The effect of exhalation flow on endogenous particle emission and phospholipid composition
Per Larsson, Björn Bake, Anita Wallin, O. Hammar, Ann-Charlotte Almstrand et al.
Respiratory Physiology & Neurobiology, Journal article 2017
Journal article

Analysis of manganese and iron in exhaled endogenous particles
Anna Bredberg, Göran Ljungqvist, Fabian Taube, Evert Ljungström, Per Larsson et al.
Journal of Analytical Atomic Spectrometry, Journal article 2014
Journal article

Effects of breath holding at low and high lung volumes on amount of exhaled particles
Helene Holmgren, Emilie Gerth, Evert Ljungström, Per Larsson, Ann-Charlotte Almstrand et al.
Respiratory Physiology & Neurobiology, Journal article 2013
Journal article

Pneumoproteins in sewage workers exposed to sewage dust
Kari Kulvik Heldal, Lars Barregård, Per Larsson, Dag G. Ellingsen
International Archives of Occupational and Environmental Health, Journal article 2013
Journal article

Showing 1 - 10 of 15

2018

Two techniques to sample non-volatiles in breath-exemplified by methadone.
Göran Ljungkvist, Shahid Ullah, Åsa Tinglev, Karina Stein, Björn Bake et al.
Journal of breath research, Journal article 2018
Journal article

2017

The effect of exhalation flow on endogenous particle emission and phospholipid composition
Per Larsson, Björn Bake, Anita Wallin, O. Hammar, Ann-Charlotte Almstrand et al.
Respiratory Physiology & Neurobiology, Journal article 2017
Journal article

2016

2015

2014

Analysis of manganese and iron in exhaled endogenous particles
Anna Bredberg, Göran Ljungqvist, Fabian Taube, Evert Ljungström, Per Larsson et al.
Journal of Analytical Atomic Spectrometry, Journal article 2014
Journal article

2013

Effects of breath holding at low and high lung volumes on amount of exhaled particles
Helene Holmgren, Emilie Gerth, Evert Ljungström, Per Larsson, Ann-Charlotte Almstrand et al.
Respiratory Physiology & Neurobiology, Journal article 2013
Journal article

Pneumoproteins in sewage workers exposed to sewage dust
Kari Kulvik Heldal, Lars Barregård, Per Larsson, Dag G. Ellingsen
International Archives of Occupational and Environmental Health, Journal article 2013
Journal article

2012

Showing 1 - 10 of 15

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