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University of Gothenburg
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Micrometric crystals of the membrane protein cytochrome oxidase.
Photo: Cecilia Safari
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Biochemistry and Structural Biology

The research groups within Biochemistry and Structural Biology study the structure, function and dynamics of proteins, as well as cellular structures. The research teams constitute a world-leading research environment and make a strong contribution to the University of Gothenburg’s top ranking within Life Science.

Research areas

Our major focus areas are

  • Development of new methods to determine the detailed structures of biomolecules
  • Dynamic protein complexes
  • Eukaryotic flagella
  • Intrinsically disordered proteins
  • Membrane proteins
  • Pharmaceutical discovery
  • Photo activated systems

Our research groups have expertise and use techniques within a range of biophysical methods such as X-ray crystallography, NMR, EPR, cryo-electron tomography and computational modelling. Time resolved structural studies is a key activity in several groups. 

Research goals

Our research aims

  • To better understand the structure-function-dynamics relationship of the cellular machinery
  • To develop new and innovative methods for production and characterization of biomolecules
  • To identify novel therapeutic drugs combatting, among others, cancer and antibiotic resistance.

Collaborations and research grants

Our researchers have extensive national and international networks. Locally, we have joint projects together with Chalmers University of Technology and Sahlgrenska Academy. We also collaborate with industry. We have, for instance, a joint doctoral student together with AstraZeneca. 

Several groups conduct experiments at research infrastructures around the world. We have very tight links with the Swedish synchrotron facility MAX IV and work closely with the Swedish NMR Centre as well as with the cryo-EM Swedish National Facility. 

Our research groups are highly successful in attracting external financing and have been awarded several prestigious research grants, including two European Research Council grants, three Wallenberg Fellow/Scholar/Molecular Medicine grants and a Distinguished Professor grant from the Swedish Research Council.

Forskargrupper

Gisela Brändén, Senior Lecturer in Membrane Protein Structure, Function and Dynamics

Development of methods for time-resolved structural studies using synchrotron and XFEL radiation, applied to study membrane-bound energy converting enzymes of the cell. Structure-based drug design to develop novel antibiotics.

More information about Gisela Brändén

Björn Burmann, Lecturer in Biophysics

The Burmann group investigates macromolecular protein machines by high-resolution Nuclear Magnetic Resonance (NMR) to decipher dynamical and structural changes underlying essential cellular functions.

More information about Björn Burmann

Leif Eriksson, Professor of Physical Chemistry

Computer based modeling of protein structures, enzymatic mechanisms, protein-protein interactions and design of new pharmaceuticals, primarily focusing on cancer and antibiotics.

More information about Leif Eriksson

Örjan Hansson, Senior Lecturer in Molecular Biophysics

The research involves studies of electron-transfer reactions in photosynthesis and of copper-containing proteins using EPR spectroscopy. In addition, we are doing research in educational science, in particular how science centers can be used in the education of science teachers.

More information about Örjan Hansson

Kristina Hedfalk, Senior Lecturer in Biochemistry

Increased knowledge of the structure and function of integral membrane proteins, key molecules in all cells, requires protein design and stable production in a suitable host.

More information about Kristina Hedfalk

Johanna Höög, Senior Lecturer in Cell Biology

Johanna Höög's group focuses on cellular electron microscopy, especially cryo-electron tomography. The research focus is on how eukaryotic flagella are constructed, especially human sperm tails.

More information about Johanna Höög

Gergely Katona, Professor of Biochemistry

Gergely Katona's group investigates the terahertz dynamics in biomolecules. The group is particularly interested in energy/information transmission and storage mediated by phonons in biological environments.

More information about Gergely Katona

Göran Karlsson, Senior Lecturer

 

Michal Maj, Postdoctoral Research Fellow in Biophysical Chemistry

The research in the Maj group combines ultrafast laser spectroscopy and structural biology techniques to investigate the molecular origins of amyloid diseases, with a particular focus on type II diabetes and Alzheimer's disease.

More information about Michal Maj

Richard Neutze, Professor

Read more about Richard Neutze

Vladislav Orekhov, Professor of Nuclear Magnetic Resonance Spectroscopy

Developing and applying NMR methodology for structural biology. We integrate novel experiments, signal processing algorithms, and artificial intelligence for removing barriers in biomolecular NMR studies.

More information about Vladislav Orekhov

Anna Reymer, Researcher in computational molecular biophysics

Using computational tools, from classical molecular dynamics to bioinformatics and machine learning, the Reymer team studies regulatory mechanisms of DNA transcription and gene expression in eukaryotes. 

More information about Anna Reymer

Sebastian Westenhoff, Professor of Biophysical Chemistry

Westenhoff's goal is to measure and visualize chemical and biological reactions. His group develops spectroscopic methods and time-resolved X-ray scattering to film structural changes with atomic precision.

More information about Sebastian Westenhoff

Research for sustainable development

Our research in Biochemistry and Systematic Biology contributes to sustainable development in many different ways. Amongst others, we work with

Zero hunger

Phytochromes are light sensitive proteins in plants and bacteria. We study their structure and thereby their detailed function. In the future, our research may contribute to the development of plants with specific characteristics that can be used to make agriculture more efficient. 

Good health and well-being

Several projects investigate the molecular mechanisms behind different cancers, bacterial resistance and neurodegenerative diseases such as dementia. We use structure-based drug design to find new candidates for pharmaceutical drugs. In addition, a predictive models of biomolecules are developed to assist diagnostics, reveal the causes of diseases and to assists drug development. Several of the proteins studied are common drug targets.

Gender equality

Fertility problems are commonly associated with the reproductive health of women. Our research on the structure of sperm tails gives a better and broader understanding of the problem of infertility. 

Clean Water and sanitation

One of our goals is to better understand the transcription of virulence genes of the bacterium Vibrio cholerae in order to be able to more efficiently get rid of it in drinking water. Another of our research targets is aquaporins, proteins that act as water filters in the cells. These can potentially be isolated and used in water filtration devices.

Affordable and clean energy

Artificial biological systems could potentially reduce the energy requirements of industry in the future. Our studies of photosynthesis contribute to a basic understanding of efficient energy production.

Industry, innovations and infrastructure

Examples from our research within drug design have been commercialised and may lead to future pharmaceuticals.