The IRE1 tetramer forms a complex with XBP1 and RtcB.
Modelling the UPRosome. A tetramer of IRE1 (dimer of dimers; blue) binds the mRNA of XBP1 (red) to splice off a part thereof. The two ends are subsequently ligated by the enzyme RtcB (green), which yields the active XBP1s.
Photo: S.J. Mahdizadeh

Computational and theoretical biochemistry

Research group
Active research
Project owner
Department of Chemistry and Molecular Biology

The Swedish Research Council, EU (H2020/MSCA), Vinnova, Sven and Lily Lawski foundation, the Foundation for Strategic Research, and Hasselblad Foundation.

Short description

Leif Eriksson's research group uses advanced computer simulations to develop new drug molecules or describe the structure, function and interactions of proteins. To aid in their work, they rely heavily on the use of Swedish supercomputing clusters. Their research focuses to a large degree on the identification of new compounds for treating cancer, for example by blocking the cells abilities to protect themselves against stress. The group also develops models of protein complexes and study how the cells read DNA (so-called transcription).

Our research

In our research, we use advanced computational chemistry and bioinformatics based tools such as homology modeling, protein-protein docking, virtual screening, molecular dynamics simulations and QM/MM methods, to develop new compounds that can be used as drug molecules, or to better understand the functions and interactions of proteins.

A large part of our work is directed towards cancer therapy, where we study a range of potential targets. In recent years, we have focused on a protein called IRE1 (inositol requiring enzyme 1) that is involved in the cellular response to / protection against stress, the unfolded protein response (UPR). Amongst other things, we explore how different proteins come together in a dynamic complex with IRE1, the ‘UPRosome’, and we have developed the first BBB penetrating inhibitor targeting the IRE1 kinase site. This compound has with great success been tested in preclinical experiments for treatment of the lethal and aggressive brain tumor glioblastoma multiforme (GBM).

Besides IRE1 and several other potential targets for cancer therapeutics, we also work with new methodology to better predict the structures of protein complexes, and machine learning in drug design. A part of our team is also conducting research on transcription factors and how these are able to recognize the ‘right’ sequence in DNA, and how DNA flexibility is governed by the specific order between nucleic acids.